Copper binds the carboxy-terminus of trefoil protein 1 (TFF1), favoring its homodimerization and motogenic activity(1222 views) Tosco A, Monti MC, Fontanella B, Montefusco S, D'Andrea LD, Ziaco B, Baldantoni D, Rio MC, Marzullo L
Keywords: Amino Acid Sequence, Amino Acid Substitution, Animals, Binding Sites, Genetics, Cell Line, Cell Movement, Copper, Metabolism, Humans, Kinetics, Molecular Sequence Data, Mutagenesis, Site-Directed, Peptide Fragments, Chemistry, Protein Multimerization, Spectrometry, Fluorescence, Matrix-Assisted Laser Desorption-Ionization, Tumor Suppressor Proteins, Wound Healing, Cell Motility, Copper Binding Protein, Gastrointestinal Peptides, Tff1, Trefoil Factors, Cysteine, Glutamic Acid, Intestinal Trefoil Factor, Trefoil Protein 1, Unclassified Drug, Tff1 Protein, Article, Binding Affinity, Cancer Cell Culture, Cancer Growth, Cancer Invasion, Carboxy Terminal Sequence, Cell Strain Ht29, Cell Strain Mcf 7, Controlled Study, Dimerization, Fluorescence Spectroscopy, Fluorometry, Gastrointestinal Tract, Human Cell, In Vitro Study, Mass Spectrometry, Metal Binding, Nucleotide Sequence, Photochemical Quenching, Protein Analysis, Protein Binding, Protein Function, Stomach Cancer, Molecular Genetics, Site Directed Mutagenesis, Spectrofluorometry, Lotus, Rattus,
Affiliations: *** IBB - CNR ***
Division of Biomedicine Arturo Leone, Department of Pharmaceutical Sciences, University of Salerno, Via Ponte don Melillo, 84084, Fisciano (SA), Italy.,
Division of Chemistry and Chemical Technologies Luigi Gomez-Paloma, Department of Pharmaceutical Sciences, University of Salerno, Via Ponte don Melillo, Fisciano (SA) 84084, Italy
Institute of Biostructures and Bioimaging, CNR, Naples, Italy
Department of Chemistry, University of Salerno, Fisciano (SA), Italy
Department of Cancer Biology, Institute of Genetics and Molecular and Cellular Biology, Université de Strasbourg, Strasbourg, France
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Copper binds the carboxy-terminus of trefoil protein 1 (TFF1), favoring its homodimerization and motogenic activity
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