Covalently immobilized RGD gradient on PEG hydrogel scaffold influences cell migration parameters (656 views)
Acta Biomaterialia (ISSN: 1878-7568, 1742-7061), 2010 Jul; 6(7): 2532-2539.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 4.824, 5-year impact factor: 5.224
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-77955271320&partnerID=40&md5=f5f6f0d04a9b54b33edd5140d834136c
Keywords: Biological Cues, Cell Instructive Materials, Cell Migration, Hydrogels, Signal Gradients, Acrylic Acid Derivative, Arginylglycylaspartic Acid, Biomaterial, Macrogol, Arginyl-Glycyl-Aspartic Acid, Macrogol Derivative, Oligopeptide, Animal Cell, Animal Tissue, Anisotropy, Cell Activity, Cell Adhesion, Cell Function, Cell Population, Controlled Study, Covalent Bond, Immobilized Cell, In Vitro Study, Mouse, Nonhuman, Priority Journal, Qualitative Analysis, Quantitative Analysis, Tissue Engineering, Cell Motion, Chemistry, Cell Movement, Polyethylene Glycols,
Affiliations:
*** IBB - CNR ***
Interdisciplinary Research Centre on Biomaterials (CRIB), Naples, Italy.
Institute for Biomedical and Composite Materials, CNR, Naples 80125, Italy
Institute of Biostructures and Bioimages, CNR, University of Naples Federico II, Naples 80134, Italy
Department of Biological Science, Section Biostructures, University of Naples Federico II, via Mezzocannone 16, 80134 Naples, Italy
References:
Lutolf, M.P., Hubbell, J.A., Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering (2005) Nat. Biotechnol., 23 (1), pp. 47-55. , Revie
Sands, R.W., Mooney, D.J., Polymers to direct cell fate by controlling the microenvironment (2007) Curr. Opin. Biotechnol., 18 (5), pp. 448-453. , Review
Cao, L., Mooney, D.J., Spatiotemporal control over growth factor signaling for therapeutic neovascularization (2007) Adv. Drug Deliv. Rev., 59 (13), pp. 1340-1350. , Review
Plummer, S.T., Wang, Q., Bohn, P.W., Stockton, R., Schwartz, M.A., Electrochemically derived gradients of the extracellular matrix protein fibronectin on gold (2003) Langmuir, 19, pp. 7528-7536
Singhvi, R., Kumar, A., Lopez, G.P., Stephanopoulous, G.N., Wang, D.I., Whitesides, G.M., Engineering cell shape and function (1994) Science, 264, pp. 696-698
Mrksich, M., A surface chemistry approach to studying cell adhesion (2000) Chem. Soc. Rev., 29, pp. 267-273
Chen, G., Ito, Y., Gradient micropattern immobilization of EGF to investigate the effect of artificial juxtacrine stimulation (2001) Biomaterials, 22, pp. 2453-2457
Ito, Y., Hayashi, M., Imanish, Y., Gradient micropattern immobilization of heparin and its interaction with cells (2001) J. Biomater. Sci. Polym. Ed., 12, pp. 367-378
Zhu, B., Eurell, T., Gunawan, R., Leckband, D., Chain-length dependence of the protein and cell resistance of oligo (ethylene glycol)-terminated self-assembled monolayers on gold (2001) J. Biomed. Mater. Res., 56 (3), pp. 406-416
Adams, D.N., Kao, E.Y.C., Hypolite, C.L., Distefano, M.D., Hu, W.S., Letourneau, P.C., Growth cones turn and migrate up an immobilized gradient of the laminin IKVAV peptide (2005) J. Neurobiol., 62, pp. 134-147
Kang, C.E., Gemeinhart, E.J., Gemeinhart, R.A., Cellular alignment by grafted adhesion peptide surface density gradients (2004) J. Biomed. Mater. Res. A, 71, pp. 403-411
Bhangale, S.M., Tjong, V., Wu, L., Yakovlev, N., Moran, P.M., Biologically active protein gradients via microstamping (2005) Adv. Mater., 17, pp. 809-813
Jeon, N.L., Dertinger, S.K.W., Chiu, D.T., Choi, I.S., Stroock, A.D., Whitesides, G.M., Generation of solution and surface gradients using microfluidic systems (2000) Langmuir, 16, pp. 8311-8316
Burdick, J.A., Khademhosseini, A., Langer, R., Fabrication of gradient hydrogels using a microfluidics/ photopolymerization process (2004) Langmuir, 20 (13), pp. 5153-5156
Boyden, S., The chemotactic effect of mixtures of antibody and antigen on polymorphonuclear leucocytes (1962) J. Exp. Med., 115, pp. 453-466
Nelson, R.D., Quie, P.G., Simmons, R.L., Chemotaxis under agarose: A new and simple method for measuring chemotaxis and spontaneous migration of human polymorphonuclear leucocytes and monocytes (1975) J. Immunol., 115, pp. 1650-1656
Moghe, P.V., Nelson, R.D., Tranquillo, R.T., Cytokine-stimulated chemotaxis of human neutrophils in a 3-D conjoined fibrin gel assay (1995) J. Immunol. Methods, 180, pp. 193-211
Knapp, D.M., Helou, E.F., Tranquillo, R.T., A fibrin or collagen gel assay for tissue cell chemotaxis: Assessment of fibroblast chemotaxis to RGDSP (1999) Exp. Cell. Res., 247, pp. 543-553
Smith, J.T., Tomfohr, J.K., Wells, M.C., Beebe, T.P., Kepler, T.B., Reichert, W.M., Measurement of cell migration on surface-bound fibronectin gradients (2004) Langmuir, 20, pp. 8279-8286
De Long, S.A., Moon, J.J., West, J.L., Covalently immobilized gradients of bFGF on hydrogel scaffolds for directed cell migration (2005) Biomaterials, 26 (16), pp. 3227-3234
De Long, S.A., Gobin, A.S., West, J.L., Covalent immobilization of RGDS on hydrogel surfaces to direct cell alignment and migration (2005) Journal of Controlled Release, 109, pp. 139-148
Smith, J.T., Elkin, J.T., Reichert, W.M., Directed cell migration on fibronectin gradients: Effect of gradient slope (2006) Exp. Cell. Res., 312 (13), pp. 2424-2432
Kipper, M.J., Kleinman, H.K., Wang, F.W., Covalent surface chemistry gradients for presenting bioactive peptides (2007) Anal. Biochem., 363 (2), pp. 175-184
Brandley, B.K., Schnaar, R.L., Tumor cell haptotaxis on covalently immobilized linear and exponential gradients of a cell adhesion peptide (1989) Dev. Biol., 135 (1), pp. 74-86
Mosesson, M.W., Siebenlist, K.R., Meh, D.A., The structure and biological features of fibrinogen and fibrin (2001) Ann. N.Y. Acad. Sci., 936, pp. 11-30
Van Hinsbergh, V.W., Collen, A., Koolwijk, P., Role of the fibrin matrix in angiogenesis (2001) Ann. N.Y. Acad. Sci., 936, pp. 426-437
Hubbell, J.A., Bioactive biomaterials (1999) Curr. Opin. Biotechnol., 10 (2), pp. 123-129. , Review
Elbert, D.L., Hubbell, J.A., Conjugate addition reactions combined with free-radical cross-linking for the design of materials for tissue engineering (2001) Biomacromolecules, 2 (2), pp. 430-441
Bryant, S.J., Nicodemus, G.D., Villanueva, I., Designing 3D photopolymer hydrogels to regulate biomechanical cues and tissue growth for cartilage tissue engineering (2008) Pharm. Res., 25 (10), pp. 2379-2386
Hern, D.L., Hubbell, J.A., Incorporation of adhesion peptides into nonadhesive hydrogels useful for tissue resurfacing (1998) J. Biomed. Mater. Res., 39, pp. 266-276
Stokes, C.L., Lauffenburger, D.A., Williams, S.K., Migration of individual microvessel endothelial cells: Stochastic model and parameter measurement (1991) J. Cell. Sci., 99, pp. 419-430
Tranquillo, R.T., Chemotactic movement of single cells (1991) ASGSB Bull., 4 (2), pp. 75-85. , Review
Sarvestani, A.S., Jabbari, E., Analysis of cell locomotion on ligand gradient substrates (2009) Biotechnol. Bioeng., 103, pp. 424-429
Fields, G.B., Noble, R.L., Solid phase peptide synthesis utilizing 9-fluorenylmethoxy-carbonil amino acids (1990) Int. J. Pept. Protein Res., 35, pp. 161-214
Dickinson, R.B., Tranquillo, R.T., Optimal estimation of cell movement indices from the statistical analysis of cell tracking data (1993) AIChE J., 39, pp. 1995-2010
Walmod, P.S., Hartmann-Petersen, R., Berezin, A., Prag, S., Kiselyov, V.V., Berezin, V., Evaluation of individual-cell motility (2001) Methods Mol. Biol., 161, pp. 59-83
Mann, B.K., Gobin, A.S., Tsai, A.T., Schmedlen, R.H., West, J.L., Smooth muscle cell growth in photopolymerized hydrogels with cell adhesive and proteolytically degradable domains: Synthetic ECM analogs for tissue engineering (2001) Biomaterials, 22, pp. 3045-3051
Massia, S.P., Hubbell, J.A., An RGD spacing of 440 nm is sufficient for integrin alpha V beta 3 mediated fibroblast spreading and 140 nm for focal contact and stress fiber formation (1991) J. Cell. Biol., 114 (5), pp. 1089-1100
Irvine, D.J., Hue, K.A., Mayes, A.M., Griffith, L.G., Simulations of cell-surface integrin binding to nanoscale-clustered adhesion ligands (2002) Biophys. J., 82, pp. 120-132
Dunn, G.A., Characterising a kinesis response: Time averaged measures of cell speed and directional persistence (1983) Agents Actions Suppl., 12, pp. 14-33
Codling, E.A., Plank, M.J., Benhamou, S., Random walk models in biology (2008) J. R Soc. Interface, 5, pp. 813-834
Di Milla, P.A., Barbee, K., Lauffenburger, D.A., Mathematical model for the effects of adhesion and mechanics on cell migration speed (1991) Biophys. J., 60 (1), pp. 15-37
Maheshwari, G., Lauffenburger, D.A., Deconstructing (and reconstructing) cell migration (1998) Microsc Res. Tech., 43, pp. 358-368
Distasi, C., Ariano, P., Zamburlin, P., Ferraro, M., In vitro analysis of neuron-glial cell interactions during cellular migration (2002) Eur. Biophys. J., 31, pp. 81-88
Lutolf, M. P., Hubbell, J. A., Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering (2005) Nat. Biotechnol., 23 (1), pp. 47-55. , Revie
Sands, R. W., Mooney, D. J., Polymers to direct cell fate by controlling the microenvironment (2007) Curr. Opin. Biotechnol., 18 (5), pp. 448-453. , Review
Plummer, S. T., Wang, Q., Bohn, P. W., Stockton, R., Schwartz, M. A., Electrochemically derived gradients of the extracellular matrix protein fibronectin on gold (2003) Langmuir, 19, pp. 7528-7536
Adams, D. N., Kao, E. Y. C., Hypolite, C. L., Distefano, M. D., Hu, W. S., Letourneau, P. C., Growth cones turn and migrate up an immobilized gradient of the laminin IKVAV peptide (2005) J. Neurobiol., 62, pp. 134-147
Kang, C. E., Gemeinhart, E. J., Gemeinhart, R. A., Cellular alignment by grafted adhesion peptide surface density gradients (2004) J. Biomed. Mater. Res. A, 71, pp. 403-411
Bhangale, S. M., Tjong, V., Wu, L., Yakovlev, N., Moran, P. M., Biologically active protein gradients via microstamping (2005) Adv. Mater., 17, pp. 809-813
Jeon, N. L., Dertinger, S. K. W., Chiu, D. T., Choi, I. S., Stroock, A. D., Whitesides, G. M., Generation of solution and surface gradients using microfluidic systems (2000) Langmuir, 16, pp. 8311-8316
Burdick, J. A., Khademhosseini, A., Langer, R., Fabrication of gradient hydrogels using a microfluidics/ photopolymerization process (2004) Langmuir, 20 (13), pp. 5153-5156
Nelson, R. D., Quie, P. G., Simmons, R. L., Chemotaxis under agarose: A new and simple method for measuring chemotaxis and spontaneous migration of human polymorphonuclear leucocytes and monocytes (1975) J. Immunol., 115, pp. 1650-1656
Moghe, P. V., Nelson, R. D., Tranquillo, R. T., Cytokine-stimulated chemotaxis of human neutrophils in a 3-D conjoined fibrin gel assay (1995) J. Immunol. Methods, 180, pp. 193-211
Knapp, D. M., Helou, E. F., Tranquillo, R. T., A fibrin or collagen gel assay for tissue cell chemotaxis: Assessment of fibroblast chemotaxis to RGDSP (1999) Exp. Cell. Res., 247, pp. 543-553
Smith, J. T., Tomfohr, J. K., Wells, M. C., Beebe, T. P., Kepler, T. B., Reichert, W. M., Measurement of cell migration on surface-bound fibronectin gradients (2004) Langmuir, 20, pp. 8279-8286
De Long, S. A., Moon, J. J., West, J. L., Covalently immobilized gradients of bFGF on hydrogel scaffolds for directed cell migration (2005) Biomaterials, 26 (16), pp. 3227-3234
De Long, S. A., Gobin, A. S., West, J. L., Covalent immobilization of RGDS on hydrogel surfaces to direct cell alignment and migration (2005) Journal of Controlled Release, 109, pp. 139-148
Smith, J. T., Elkin, J. T., Reichert, W. M., Directed cell migration on fibronectin gradients: Effect of gradient slope (2006) Exp. Cell. Res., 312 (13), pp. 2424-2432
Kipper, M. J., Kleinman, H. K., Wang, F. W., Covalent surface chemistry gradients for presenting bioactive peptides (2007) Anal. Biochem., 363 (2), pp. 175-184
Brandley, B. K., Schnaar, R. L., Tumor cell haptotaxis on covalently immobilized linear and exponential gradients of a cell adhesion peptide (1989) Dev. Biol., 135 (1), pp. 74-86
Mosesson, M. W., Siebenlist, K. R., Meh, D. A., The structure and biological features of fibrinogen and fibrin (2001) Ann. N. Y. Acad. Sci., 936, pp. 11-30
Van Hinsbergh, V. W., Collen, A., Koolwijk, P., Role of the fibrin matrix in angiogenesis (2001) Ann. N. Y. Acad. Sci., 936, pp. 426-437
Hubbell, J. A., Bioactive biomaterials (1999) Curr. Opin. Biotechnol., 10 (2), pp. 123-129. , Review
Elbert, D. L., Hubbell, J. A., Conjugate addition reactions combined with free-radical cross-linking for the design of materials for tissue engineering (2001) Biomacromolecules, 2 (2), pp. 430-441
Bryant, S. J., Nicodemus, G. D., Villanueva, I., Designing 3D photopolymer hydrogels to regulate biomechanical cues and tissue growth for cartilage tissue engineering (2008) Pharm. Res., 25 (10), pp. 2379-2386
Hern, D. L., Hubbell, J. A., Incorporation of adhesion peptides into nonadhesive hydrogels useful for tissue resurfacing (1998) J. Biomed. Mater. Res., 39, pp. 266-276
Stokes, C. L., Lauffenburger, D. A., Williams, S. K., Migration of individual microvessel endothelial cells: Stochastic model and parameter measurement (1991) J. Cell. Sci., 99, pp. 419-430
Sarvestani, A. S., Jabbari, E., Analysis of cell locomotion on ligand gradient substrates (2009) Biotechnol. Bioeng., 103, pp. 424-429
Fields, G. B., Noble, R. L., Solid phase peptide synthesis utilizing 9-fluorenylmethoxy-carbonil amino acids (1990) Int. J. Pept. Protein Res., 35, pp. 161-214
Dickinson, R. B., Tranquillo, R. T., Optimal estimation of cell movement indices from the statistical analysis of cell tracking data (1993) AIChE J., 39, pp. 1995-2010
Walmod, P. S., Hartmann-Petersen, R., Berezin, A., Prag, S., Kiselyov, V. V., Berezin, V., Evaluation of individual-cell motility (2001) Methods Mol. Biol., 161, pp. 59-83
Mann, B. K., Gobin, A. S., Tsai, A. T., Schmedlen, R. H., West, J. L., Smooth muscle cell growth in photopolymerized hydrogels with cell adhesive and proteolytically degradable domains: Synthetic ECM analogs for tissue engineering (2001) Biomaterials, 22, pp. 3045-3051
Massia, S. P., Hubbell, J. A., An RGD spacing of 440 nm is sufficient for integrin alpha V beta 3 mediated fibroblast spreading and 140 nm for focal contact and stress fiber formation (1991) J. Cell. Biol., 114 (5), pp. 1089-1100
Irvine, D. J., Hue, K. A., Mayes, A. M., Griffith, L. G., Simulations of cell-surface integrin binding to nanoscale-clustered adhesion ligands (2002) Biophys. J., 82, pp. 120-132
Dunn, G. A., Characterising a kinesis response: Time averaged measures of cell speed and directional persistence (1983) Agents Actions Suppl., 12, pp. 14-33
Codling, E. A., Plank, M. J., Benhamou, S., Random walk models in biology (2008) J. R Soc. Interface, 5, pp. 813-834
Di Milla, P. A., Barbee, K., Lauffenburger, D. A., Mathematical model for the effects of adhesion and mechanics on cell migration speed (1991) Biophys. J., 60 (1), pp. 15-37
Acta Biomaterialia (ISSN: 1878-7568, 1742-7061), 2010 Jul; 6(7): 2532-2539.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 4.824, 5-year impact factor: 5.224
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-77955271320&partnerID=40&md5=f5f6f0d04a9b54b33edd5140d834136c
Keywords: Biological Cues, Cell Instructive Materials, Cell Migration, Hydrogels, Signal Gradients, Acrylic Acid Derivative, Arginylglycylaspartic Acid, Biomaterial, Macrogol, Arginyl-Glycyl-Aspartic Acid, Macrogol Derivative, Oligopeptide, Animal Cell, Animal Tissue, Anisotropy, Cell Activity, Cell Adhesion, Cell Function, Cell Population, Controlled Study, Covalent Bond, Immobilized Cell, In Vitro Study, Mouse, Nonhuman, Priority Journal, Qualitative Analysis, Quantitative Analysis, Tissue Engineering, Cell Motion, Chemistry, Cell Movement, Polyethylene Glycols,
Affiliations:
*** IBB - CNR ***
Interdisciplinary Research Centre on Biomaterials (CRIB), Naples, Italy.
Institute for Biomedical and Composite Materials, CNR, Naples 80125, Italy
Institute of Biostructures and Bioimages, CNR, University of Naples Federico II, Naples 80134, Italy
Department of Biological Science, Section Biostructures, University of Naples Federico II, via Mezzocannone 16, 80134 Naples, Italy
References:
Lutolf, M.P., Hubbell, J.A., Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering (2005) Nat. Biotechnol., 23 (1), pp. 47-55. , Revie
Sands, R.W., Mooney, D.J., Polymers to direct cell fate by controlling the microenvironment (2007) Curr. Opin. Biotechnol., 18 (5), pp. 448-453. , Review
Cao, L., Mooney, D.J., Spatiotemporal control over growth factor signaling for therapeutic neovascularization (2007) Adv. Drug Deliv. Rev., 59 (13), pp. 1340-1350. , Review
Plummer, S.T., Wang, Q., Bohn, P.W., Stockton, R., Schwartz, M.A., Electrochemically derived gradients of the extracellular matrix protein fibronectin on gold (2003) Langmuir, 19, pp. 7528-7536
Singhvi, R., Kumar, A., Lopez, G.P., Stephanopoulous, G.N., Wang, D.I., Whitesides, G.M., Engineering cell shape and function (1994) Science, 264, pp. 696-698
Mrksich, M., A surface chemistry approach to studying cell adhesion (2000) Chem. Soc. Rev., 29, pp. 267-273
Chen, G., Ito, Y., Gradient micropattern immobilization of EGF to investigate the effect of artificial juxtacrine stimulation (2001) Biomaterials, 22, pp. 2453-2457
Ito, Y., Hayashi, M., Imanish, Y., Gradient micropattern immobilization of heparin and its interaction with cells (2001) J. Biomater. Sci. Polym. Ed., 12, pp. 367-378
Zhu, B., Eurell, T., Gunawan, R., Leckband, D., Chain-length dependence of the protein and cell resistance of oligo (ethylene glycol)-terminated self-assembled monolayers on gold (2001) J. Biomed. Mater. Res., 56 (3), pp. 406-416
Adams, D.N., Kao, E.Y.C., Hypolite, C.L., Distefano, M.D., Hu, W.S., Letourneau, P.C., Growth cones turn and migrate up an immobilized gradient of the laminin IKVAV peptide (2005) J. Neurobiol., 62, pp. 134-147
Kang, C.E., Gemeinhart, E.J., Gemeinhart, R.A., Cellular alignment by grafted adhesion peptide surface density gradients (2004) J. Biomed. Mater. Res. A, 71, pp. 403-411
Bhangale, S.M., Tjong, V., Wu, L., Yakovlev, N., Moran, P.M., Biologically active protein gradients via microstamping (2005) Adv. Mater., 17, pp. 809-813
Jeon, N.L., Dertinger, S.K.W., Chiu, D.T., Choi, I.S., Stroock, A.D., Whitesides, G.M., Generation of solution and surface gradients using microfluidic systems (2000) Langmuir, 16, pp. 8311-8316
Burdick, J.A., Khademhosseini, A., Langer, R., Fabrication of gradient hydrogels using a microfluidics/ photopolymerization process (2004) Langmuir, 20 (13), pp. 5153-5156
Boyden, S., The chemotactic effect of mixtures of antibody and antigen on polymorphonuclear leucocytes (1962) J. Exp. Med., 115, pp. 453-466
Nelson, R.D., Quie, P.G., Simmons, R.L., Chemotaxis under agarose: A new and simple method for measuring chemotaxis and spontaneous migration of human polymorphonuclear leucocytes and monocytes (1975) J. Immunol., 115, pp. 1650-1656
Moghe, P.V., Nelson, R.D., Tranquillo, R.T., Cytokine-stimulated chemotaxis of human neutrophils in a 3-D conjoined fibrin gel assay (1995) J. Immunol. Methods, 180, pp. 193-211
Knapp, D.M., Helou, E.F., Tranquillo, R.T., A fibrin or collagen gel assay for tissue cell chemotaxis: Assessment of fibroblast chemotaxis to RGDSP (1999) Exp. Cell. Res., 247, pp. 543-553
Smith, J.T., Tomfohr, J.K., Wells, M.C., Beebe, T.P., Kepler, T.B., Reichert, W.M., Measurement of cell migration on surface-bound fibronectin gradients (2004) Langmuir, 20, pp. 8279-8286
De Long, S.A., Moon, J.J., West, J.L., Covalently immobilized gradients of bFGF on hydrogel scaffolds for directed cell migration (2005) Biomaterials, 26 (16), pp. 3227-3234
De Long, S.A., Gobin, A.S., West, J.L., Covalent immobilization of RGDS on hydrogel surfaces to direct cell alignment and migration (2005) Journal of Controlled Release, 109, pp. 139-148
Smith, J.T., Elkin, J.T., Reichert, W.M., Directed cell migration on fibronectin gradients: Effect of gradient slope (2006) Exp. Cell. Res., 312 (13), pp. 2424-2432
Kipper, M.J., Kleinman, H.K., Wang, F.W., Covalent surface chemistry gradients for presenting bioactive peptides (2007) Anal. Biochem., 363 (2), pp. 175-184
Brandley, B.K., Schnaar, R.L., Tumor cell haptotaxis on covalently immobilized linear and exponential gradients of a cell adhesion peptide (1989) Dev. Biol., 135 (1), pp. 74-86
Mosesson, M.W., Siebenlist, K.R., Meh, D.A., The structure and biological features of fibrinogen and fibrin (2001) Ann. N.Y. Acad. Sci., 936, pp. 11-30
Van Hinsbergh, V.W., Collen, A., Koolwijk, P., Role of the fibrin matrix in angiogenesis (2001) Ann. N.Y. Acad. Sci., 936, pp. 426-437
Hubbell, J.A., Bioactive biomaterials (1999) Curr. Opin. Biotechnol., 10 (2), pp. 123-129. , Review
Elbert, D.L., Hubbell, J.A., Conjugate addition reactions combined with free-radical cross-linking for the design of materials for tissue engineering (2001) Biomacromolecules, 2 (2), pp. 430-441
Bryant, S.J., Nicodemus, G.D., Villanueva, I., Designing 3D photopolymer hydrogels to regulate biomechanical cues and tissue growth for cartilage tissue engineering (2008) Pharm. Res., 25 (10), pp. 2379-2386
Hern, D.L., Hubbell, J.A., Incorporation of adhesion peptides into nonadhesive hydrogels useful for tissue resurfacing (1998) J. Biomed. Mater. Res., 39, pp. 266-276
Stokes, C.L., Lauffenburger, D.A., Williams, S.K., Migration of individual microvessel endothelial cells: Stochastic model and parameter measurement (1991) J. Cell. Sci., 99, pp. 419-430
Tranquillo, R.T., Chemotactic movement of single cells (1991) ASGSB Bull., 4 (2), pp. 75-85. , Review
Sarvestani, A.S., Jabbari, E., Analysis of cell locomotion on ligand gradient substrates (2009) Biotechnol. Bioeng., 103, pp. 424-429
Fields, G.B., Noble, R.L., Solid phase peptide synthesis utilizing 9-fluorenylmethoxy-carbonil amino acids (1990) Int. J. Pept. Protein Res., 35, pp. 161-214
Dickinson, R.B., Tranquillo, R.T., Optimal estimation of cell movement indices from the statistical analysis of cell tracking data (1993) AIChE J., 39, pp. 1995-2010
Walmod, P.S., Hartmann-Petersen, R., Berezin, A., Prag, S., Kiselyov, V.V., Berezin, V., Evaluation of individual-cell motility (2001) Methods Mol. Biol., 161, pp. 59-83
Mann, B.K., Gobin, A.S., Tsai, A.T., Schmedlen, R.H., West, J.L., Smooth muscle cell growth in photopolymerized hydrogels with cell adhesive and proteolytically degradable domains: Synthetic ECM analogs for tissue engineering (2001) Biomaterials, 22, pp. 3045-3051
Massia, S.P., Hubbell, J.A., An RGD spacing of 440 nm is sufficient for integrin alpha V beta 3 mediated fibroblast spreading and 140 nm for focal contact and stress fiber formation (1991) J. Cell. Biol., 114 (5), pp. 1089-1100
Irvine, D.J., Hue, K.A., Mayes, A.M., Griffith, L.G., Simulations of cell-surface integrin binding to nanoscale-clustered adhesion ligands (2002) Biophys. J., 82, pp. 120-132
Dunn, G.A., Characterising a kinesis response: Time averaged measures of cell speed and directional persistence (1983) Agents Actions Suppl., 12, pp. 14-33
Codling, E.A., Plank, M.J., Benhamou, S., Random walk models in biology (2008) J. R Soc. Interface, 5, pp. 813-834
Di Milla, P.A., Barbee, K., Lauffenburger, D.A., Mathematical model for the effects of adhesion and mechanics on cell migration speed (1991) Biophys. J., 60 (1), pp. 15-37
Maheshwari, G., Lauffenburger, D.A., Deconstructing (and reconstructing) cell migration (1998) Microsc Res. Tech., 43, pp. 358-368
Distasi, C., Ariano, P., Zamburlin, P., Ferraro, M., In vitro analysis of neuron-glial cell interactions during cellular migration (2002) Eur. Biophys. J., 31, pp. 81-88
Lutolf, M. P., Hubbell, J. A., Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering (2005) Nat. Biotechnol., 23 (1), pp. 47-55. , Revie
Sands, R. W., Mooney, D. J., Polymers to direct cell fate by controlling the microenvironment (2007) Curr. Opin. Biotechnol., 18 (5), pp. 448-453. , Review
Plummer, S. T., Wang, Q., Bohn, P. W., Stockton, R., Schwartz, M. A., Electrochemically derived gradients of the extracellular matrix protein fibronectin on gold (2003) Langmuir, 19, pp. 7528-7536
Adams, D. N., Kao, E. Y. C., Hypolite, C. L., Distefano, M. D., Hu, W. S., Letourneau, P. C., Growth cones turn and migrate up an immobilized gradient of the laminin IKVAV peptide (2005) J. Neurobiol., 62, pp. 134-147
Kang, C. E., Gemeinhart, E. J., Gemeinhart, R. A., Cellular alignment by grafted adhesion peptide surface density gradients (2004) J. Biomed. Mater. Res. A, 71, pp. 403-411
Bhangale, S. M., Tjong, V., Wu, L., Yakovlev, N., Moran, P. M., Biologically active protein gradients via microstamping (2005) Adv. Mater., 17, pp. 809-813
Jeon, N. L., Dertinger, S. K. W., Chiu, D. T., Choi, I. S., Stroock, A. D., Whitesides, G. M., Generation of solution and surface gradients using microfluidic systems (2000) Langmuir, 16, pp. 8311-8316
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Covalently immobilized RGD gradient on PEG hydrogel scaffold influences cell migration parameters
Understanding the influence of a controlled spatial distribution of biological cues on cell activities can be useful to design "cell instructive" materials, able to control and guide the formation of engineered tissues in vivo and in vitro. To this purpose, biochemical and mechanical properties of the resulting biomaterial must be carefully designed and controlled. In this work, the effect of covalently immobilized RGD peptide gradients on poly(ethylene glycol) diacrylate hydrogels on cell behaviour was studied. We set up a mechanical device generating gradients based on a fluidic chamber. Cell response to RGD gradients with different slope (0.7, 1 and 2 mM cm(-1)) was qualitatively and quantitatively assessed by evaluating cell adhesion and, in particular, cell migration, compared to cells seeded on hydrogels with uniform distribution of RGD peptides. To evaluate the influence of RGD gradient and to exclude any concentration effect on cell response, all analyses were carried out in a specific region of the gradients which displayed the same average concentration of RGD (1.5 mM). Results suggest that cells recognize the RGD gradient and adhere onto it assuming a stretched shape. Moreover, cells tend to migrate in the direction of the gradient, as their speed is higher than that of cells migrating on hydrogels with a uniform distribution of RGD and increases by increasing RGD gradient steepness. This increment is due to an augmentation of bias speed component of the mean squared speed, that is, the drift of the cell population migrating on the anisotropic surface provided by the RGD gradient. Copyright 2010 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
Understanding the influence of a controlled spatial distribution of biological cues on cell activities can be useful to design "cell instructive" materials, able to control and guide the formation of engineered tissues in vivo and in vitro. To this purpose, biochemical and mechanical properties of the resulting biomaterial must be carefully designed and controlled. In this work, the effect of covalently immobilized RGD peptide gradients on poly(ethylene glycol) diacrylate hydrogels on cell behaviour was studied. We set up a mechanical device generating gradients based on a fluidic chamber. Cell response to RGD gradients with different slope (0.7, 1 and 2 mM cm(-1)) was qualitatively and quantitatively assessed by evaluating cell adhesion and, in particular, cell migration, compared to cells seeded on hydrogels with uniform distribution of RGD peptides. To evaluate the influence of RGD gradient and to exclude any concentration effect on cell response, all analyses were carried out in a specific region of the gradients which displayed the same average concentration of RGD (1.5 mM). Results suggest that cells recognize the RGD gradient and adhere onto it assuming a stretched shape. Moreover, cells tend to migrate in the direction of the gradient, as their speed is higher than that of cells migrating on hydrogels with a uniform distribution of RGD and increases by increasing RGD gradient steepness. This increment is due to an augmentation of bias speed component of the mean squared speed, that is, the drift of the cell population migrating on the anisotropic surface provided by the RGD gradient. Copyright 2010 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
Covalently immobilized RGD gradient on PEG hydrogel scaffold influences cell migration parameters
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Covalently immobilized RGD gradient on PEG hydrogel scaffold influences cell migration parameters
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J Cell Physiol (ISSN: 1097-4652electronic, 0021-9541linking), 2018 Jan 18; 233(8): 6241-6249.
Impact Factor: 5.546
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Camorani S, Hill BS, Fontanella R, Greco A, Gramanzini M, Auletta L, Gargiulo S, Albanese S, Lucarelli E, Cerchia L, Zannetti A
* Inhibition of Bone Marrow-Derived Mesenchymal Stem Cells Homing Towards Triple-Negative Breast Cancer Microenvironment Using an Anti-PDGFRbeta Aptamer (697 views) (PDF 210 views)
Theranostics (ISSN: 1838-7640, 1838-7640electronic), 2017 Aug 22; 7(14): 3595-3607.
Impact Factor: 8.537
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Roviello GN, Iannitti R, Roviello V, Palumbo R, Simonyan H, Vicidomini C
* Synthesis and biological evaluation of a novel Amadori compound (406 views)
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2017 Feb; 49(2): 327-335.
Impact Factor: 2.906
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Fontanella R, Pelagalli A, Nardelli A, D'Alterio C, Ierano C, Cerchia L, Lucarelli E, Scala S, Zannetti A
* A novel antagonist of CXCR4 prevents bone marrow-derived mesenchymal stem cell-mediated osteosarcoma and hepatocellular carcinoma cell migration and invasion (931 views) (PDF 283 views)
Cancer Lett (ISSN: 0304-3835), 2015 Oct 27; 370(1): 100-107.
Impact Factor: 7.36
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Giacomelli C, Trincavelli ML, Satriano C, Hansson O, La Mendola D, Rizzarelli E, Martini C
* Copper (II) ions modulate Angiogenin activity in human endothelial cells (424 views)
Int J Biochem Cell B (ISSN: 1357-2725), 2015 Mar; 60: 185-196.
Impact Factor: 3.905
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Vincenzi M, Costantini S, Scala S, Tesauro D, Accardo A, Leone M, Colonna G, Guillon J, Portella L, Trotta AM, Ronga L, Rossi F
* Conformational ensembles explored dynamically from disordered peptides targeting chemokine receptor CXCR4 (604 views)
Int J Mol Sc (ISSN: 1422-0067, 1661-6596, 1422-0067linking), 2015; 16(6): 12159-12173.
Impact Factor: 3.257
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Perri F, Pacelli R, Della Vittoria Scarpati G, Cella L, Giuliano M, Caponigro F, Pepe S
* Radioresistance in head and neck squamous cell carcinoma: Biological bases and therapeutic implications (524 views)
Head Neck-J Sci Spec (ISSN: 1043-3074), 2015; 37(5): 763-770.
Impact Factor: 2.76
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Neve Polimeno M, Ierano C, D'Alterio C, Simona Losito N, Napolitano M, Portella L, Scognamiglio G, Tatangelo F, Maria Trotta A, Curley S, Costantini S, Liuzzi R, Izzo F, Scala S
* CXCR4 expression affects overall survival of HCC patients whereas CXCR7 expression does not (671 views)
Cell Mol Immunol (ISSN: 1672-7681), 2014 Nov 3; 12(4): 474-482.
Impact Factor: 4.112
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Formisano L, Nappi L, Rosa R, Marciano R, D'Amato C, D'Amato V, Damiano V, Raimondo L, Iommelli F, Scorziello A, Troncone G, Veneziani BM, Parsons SJ, De Placido S, Bianco R
* Epidermal growth factor-receptor activation modulates Src-dependent resistance to lapatinib in breast cancer models (460 views)
Breast Cancer Res Biomed Central Ltd (ISSN: 1465-5411), 2014; 16(3): R45-R45.
Impact Factor: 0.635
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Portella L, Vitale R, De Luca S, D'Alterio C, Ieranò C, Napolitano M, Riccio A, Polimeno MN, Monfregola L, Barbieri A, Luciano A, Ciarmiello A, Arra C, Castello G, Amodeo P, Scala S
* Preclinical Development of a Novel Class of CXCR4 Antagonist Impairing Solid Tumors Growth and Metastases (505 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2013 Sep 13; 8(9): N/D-N/D.
Impact Factor: 3.534
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Romano S, Staibano S, Greco A, Brunetti A, Nappo G, Ilardi G, Martinelli R, Sorrentino A, Di Pace A, Mascolo M, Bisogni R, Scalvenzi M, Alfano B, Romano M
* FK506 binding protein 51 positively regulates melanoma stemness and metastatic potential (431 views) (PDF 242 views)
Cell Death & (ISSN: 2041-4889, 2041-4889electronic), 2013 Apr 4; 4(6): e578-e578.
Impact Factor: 5.333
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Pisano M, De Paola I, Nieddu V, Sassu I, Cossu S, Galleri G, Del Gatto A, Budroni M, Cossu A, Saviano M, Palmieri G, Zaccaro L, Rozzo C
* In vitro activity of the alphavbeta3 integrin antagonist RGDechi-hCit on malignant melanoma cells (447 views)
Anticancer Res (ISSN: 0250-7005, 0250-0700, 1791-7530electronic), 2013 Mar; 33(3): 871-879.
Impact Factor: 1.045
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Galasso G, De Rosa R, Ciccarelli M, Sorriento D, Del Giudice C, Strisciuglio T, De Biase C, Luciano R, Piccolo R, Pierri A, Di Gioia G, Prevete N, Trimarco B, Piscione F, Iaccarino G
* β2-adrenergic receptor stimulation improves endothelial progenitor cell-mediated ischemic neoangiogenesis (473 views)
Circ Res (ISSN: 0009-7330, 1524-4571electronic, 0009-7330linking), 2013; 112(7): 1026-1034.
Impact Factor: 11.089
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Finetti F, Basile A, Capasso D, Di Gaetano S, Di Stasi R, Pascale M, Turco CM, Ziche M, Morbidelli L, D'Andrea LD
* Functional and pharmacological characterization of a VEGF mimetic peptide on reparative angiogenesis (607 views)
Biochem Pharmacol Biochemical Pharmacology (ISSN: 0006-2952, 1873-2968), 2012 Sep 1; 84(3): 303-311.
Impact Factor: 4.576
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Orsi S, De Capua A, Guarnieri D, Marasco D, Netti PA
* Cell recruitment and transfection in gene activated collagen matrix (385 views)
Biomaterials (ISSN: 0142-9612, 1878-5905electronic, 0142-9612linking), 2010 Jan; 31(3): 570-576.
Impact Factor: 7.883
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Carriero MV, Longanesi-cattani I, Bifulco K, Maglio O, Lista L, Barbieri A, Votta G, Masucci MT, Arra C, Franco R, De Rosa M, Stoppelli MP, Pavone V
* Structure-based design of an urokinase-type plasminogen activator receptor-derived peptide inhibiting cell migration and lung metastasis (498 views)
Mol Cancer Ther (ISSN: 1535-7163, 1538-8514electronic, 1535-7163linking), 2009 Sep; 8(9): 2708-2717.
Impact Factor: 4.953
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D'Andrea LD, Del Gatto A, De Rosa L, Romanelli A, Pedone C
* Peptides targeting angiogenesis related growth factor receptors (14589 views)
Curr Pharm Des Current Pharmaceutical Design (ISSN: 1873-4286, 1381-6128), 2009 Jul; 15(21): 2414-2429.
Impact Factor: 4.414
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Ierano C, Giuliano P, D'Alterio C, Cioffi M, Mettivier V, Portella L, Napolitano M, Barbieri A, Arra C, Liguori G, Franco R, Palmieri G, Rozzo C, Pacelli R, Castello G, Scala S
* A point mutation (G574A) in the chemokine receptor CXCR4 detected in human cancer cells enhances migration (394 views)
Cell Cycle (ISSN: 1538-4101), 2009 Apr 15; 8(8): 1228-1237.
Impact Factor: 4.087
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Pavone V, Lista L, Maglio O, Longanesi-cattani I, Bifulco K, Arra C, V , Carriero M
* Sub-femtomolar activity of a new cell migration inhibitor (214 views)
Biopolymers, 2009; 92: 350-350.
Impact Factor: 0
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Gioia M, Monaco S, Van Den Steen PE, Sbardella D, Grasso G, Marini S, Overall CM, Opdenakker G, Coletta M
* The Collagen Binding Domain of Gelatinase A Modulates Degradation of Collagen IV by Gelatinase (460 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2009; 386(2): 419-434.
Impact Factor: 3.871
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Bifulco K, Longanesi-cattani I, Gargiulo L, Maglio O, Cataldi M, De Rosa M, Stoppelli MP, Pavone V, Carriero MV
* An urokinase receptor antagonist that inhibits cell migration by blocking the formyl peptide receptor (380 views)
Febs Lett (ISSN: 0014-5793print, 0014-5793linking, 1873-3468electronic), 2008 Apr 2; 582(7): 1141-1146.
Impact Factor: 3.264
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Guarnieri D, Borzacchiello A, De Capua A, Marasco D, Ruvo M, Netti PA
* Dependence of cell migration parameters on steepness of RGD gradient slope (377 views)
World Biomater Congr (ISSN: 9781-6156), 2008; 1: 271-271.
Impact Factor: 0
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Sorriento D, Ciccarelli M, Santulli G, Campanile A, Altobelli GG, Cimini V, Galasso G, Astone D, Piscione F, Pastore L, Trimarco B, Iaccarino G
* The G-protein-coupled receptor kinase 5 inhibits NFκB transcriptional activity by inducing nuclear accumulation of IκBα (438 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2008; 105(46): 17818-17823.
Impact Factor: 9.38
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Bucci EM, Valente M, Musumeci D, Sapio R, Anrò V, Roviello GN, Moccia M
* ODN-based drugs for targeting of extracellular proteins (284 views)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1525-7770), 2007; 26(8-9): 1047-1050.
Impact Factor: 0.723
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D'Andrea LD, Del Gatto A, Pedone C, Benedetti E
* Peptide-based molecules in angiogenesis (843 views)
Chem Biol Drug Des (ISSN: 1747-0277, 1747-0285, 1747-0277linking), 2006 Feb; 67(2): 115-126.
Impact Factor: 2.507
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Zannetti A, Del Vecchio S, Romanelli A, Scala S, Saviano M, Cali' G, Stoppelli MP, Pedone C, Salvatore M
* Inhibition of Sp1 activity by a decoy PNA-DNA chimera prevents urokinase receptor expression and migration of breast cancer cells (512 views)
Biochem Pharmacol Biochemical Pharmacology (ISSN: 0006-2952, 1873-2968), 2005 Nov 1; 70(9): 1277-1287.
Impact Factor: 3.617
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Carriero M, Del Vecchio S, Capozzoli M, Franco P, Fontana L, Zannetti A, Botti G, D'Aiuto G, Salvatore M, Stoppelli M
Urokinase receptor interacts with alpha(v)beta(5) vitronectin receptor, promoting urokinase-dependent cell migration in breast cancer (394 views)
Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 1999 Oct 15; 59(20): N/D-N/D.
Impact Factor: 8.614
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34 Records (28 excluding Abstracts).
Total impact factor: 158.415 (140.299 excluding Abstracts).
Total 5 year impact factor: 137.332 (119.373 excluding Abstracts).
Total impact factor: 158.415 (140.299 excluding Abstracts).
Total 5 year impact factor: 137.332 (119.373 excluding Abstracts).
656 views. Last view on Tuesday 23 May 2023, 22:41:36
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