Dimerisation and structural integrity of Heparin Binding Hemagglutinin A from Mycobacterium tuberculosis: Implications for bacterial agglutination (494 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 0014-5793linking), 2010 Mar 19; 584(6): 1091-1096.
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Paper type: Journal Article,
Impact factor: 3.601, 5-year impact factor: 3.399
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-77950371492&partnerID=40&md5=4a68d914afd3f08f93e5a6c6c23bfff5
Keywords: Agglutination, Coiled Coil, Dimerisation, Stability, Tuberculosis, Heparin Binding Hemagglutinin Adhesin, Monomer, Protein, Unclassified Drug, Virulence Factor, Article, Cell Interaction, Controlled Study, Dimerization, Epithelium Cell, Experiment, Molecular Model, Molecular Stability, Mycobacterium Tuberculosis, Primary Infection, Priority Journal, Protein Conformation, Protein Denaturation, Protein Structure, Amino Acid Sequence, Antigens, Bacterial Adhesion, Lectins, Light, Molecular Sequence Data, Protein Folding, Protein Multimerization, Protein Stability, Scattering, Radiation, Temperature, Bacteria (microorganisms),
Affiliations:
*** IBB - CNR ***
Istitute of Biostructures and Bioimaging, C.N.R., I-80134 - Naples, Italy
Department of Chemistry Paolo Corradini, University of Naples Federico II, Complesso Universitario Monte S. Angelo, I-80126, Naples, Italy
Department of Biological and Environmental Sciences, University of Sannio, I-82100 Benevento, Italy
References:
Menozzi, F.D., Bischoff, R., Fort, E., Brennan, M.J., Locht, C., Molecular characterization of the mycobacterial heparin-binding hemagglutinin, a mycobacterial adhesin (1998) Proc. Natl. Acad. Sci. USA, 95, pp. 12625-1263
Pethe, K., Alonso, S., Biet, F., Delogu, G., Brennan, M.J., Locht, C., Menozzi, F.D., The heparin-binding haemagglutinin of M. tuberculosis is required for extrapulmonary dissemination (2001) Nature, 412, pp. 190-194
Pethe, K., Aumercier, M., Fort, E., Gatot, C., Locht, C., Menozzi, F.D., Characterization of the heparin-binding site of the mycobacterial heparin-binding hemagglutinin adhesin (2000) J. Biol. Chem., 275, pp. 14273-14280
Heise, T., Dersch, P., Identification of a domain in Yersinia virulence factor YadA that is crucial for extracellular matrix-specific cell adhesion and uptake (2006) Proc. Natl. Acad. Sci. USA, 103, pp. 3375-3380
Verbelen, C., Raze, D., Dewitte, F., Locht, C., Dufrene, Y.F., Single-molecule force spectroscopy of mycobacterial adhesin-adhesin interactions (2007) J. Bacteriol., 189, pp. 8801-8806
Esposito, C., Pethoukov, M.V., Svergun, D.I., Ruggiero, A., Pedone, C., Pedone, E., Berisio, R., Evidence for an elongated dimeric structure of heparin-binding hemagglutinin from Mycobacterium tuberculosis (2008) J. Bacteriol., 190, pp. 4749-4753
Barone, G., Del Vecchio, P., Fessas, D., Giancola, C., Graziano, G., (1992) J. Therm. Anal., 38, p. 2779
Privalov, P.L., Stability of proteins: small globular proteins (1979) Adv. Protein Chem., 33, pp. 167-241
Zhou, Y., Hall, C.K., Karplus, M., The calorimetric criterion for a two-state process revisited (1999) Protein Sci., 8, pp. 1064-1074
Kleywegt, G.J., Jones, T.A., Model building and refinement practice (1997) Methods Enzymol., 277, pp. 208-230
Van Der Spoel, D., Lindahl, E., Hess, B., Groenhof, G., Mark, A.E., Berendsen, H.J., GROMACS: fast, flexible, and free (2005) J. Comput. Chem., 26, pp. 1701-1718
Walshaw, J., Woolfson, D.N., Socket: a program for identifying and analysing coiled-coil motifs within protein structures (2001) J. Mol. Biol., 307, pp. 1427-1450
Steinmetz, M.O., Molecular basis of coiled-coil formation (2007) Proc. Natl. Acad. Sci. USA, 104, pp. 7062-7067
Wolf, E., Kim, P.S., Berger, B., MultiCoil: a program for predicting two- and three-stranded coiled coils (1997) Protein Sci., 6, pp. 1179-1189
Hofmann, K., Stoffel, W., TMbase - a database of membrane spanning proteins segments (1993) Biol. Chem. Hoppe-Seyler, 374, p. 166
Jones, D.T., Taylor, W.R., Thornton, J.M., A model recognition approach to the prediction of all-helical membrane protein structure and topology (1994) Biochemistry, 33, pp. 3038-3049
Kall, L., Krogh, A., Sonnhammer, E.L., Advantages of combined transmembrane topology and signal peptide prediction-the Phobius web server (2007) Nucleic Acids Res., 35, pp. W429-W432
Hoffmann, C., Leis, A., Niederweis, M., Plitzko, J.M., Engelhardt, H., Disclosure of the mycobacterial outer membrane: cryo-electron tomography and vitreous sections reveal the lipid bilayer structure (2008) Proc. Natl. Acad. Sci. USA, 105, pp. 3963-3967
Niederweis, M., Danilchanka, O., Huff, J., Hoffmann, C., Engelhardt, H., (2010), Mycobacterial outer membranes: in search of proteins. Trends Microbiol., in pressNewman, J.R., Wolf, E., Kim, P.S., A computationally directed screen identifying interacting coiled coils from Saccharomyces cerevisiae (2000) Proc. Natl. Acad. Sci. USA, 97, pp. 13203-13208
Hurme, R., Berndt, K.D., Normark, S.J., Rhen, M., A proteinaceous gene regulatory thermometer in Salmonella (1997) Cell, 90, pp. 55-64
McFarlane, A.A., Orriss, G.L., Stetefeld, J., The use of coiled-coil proteins in drug delivery systems (2009) Eur. J. Pharmacol., 625, pp. 101-107
Meier, M., Burkhard, P., Statistical analysis of intrahelical ionic interactions in alpha-helices and coiled coils (2006) J. Struct. Biol., 155, pp. 116-129
Lee, D.L., Lavigne, P., Hodges, R.S., Are trigger sequences essential in the folding of two-stranded alpha-helical coiled-coils? (2001) J. Mol. Biol., 306, pp. 539-553
Tan, K., Heparin-induced cis- and trans-dimerization modes of the thrombospondin-1 N-terminal domain (2008) J. Biol. Chem., 283, pp. 3932-3941
Goodger, S.J., Robinson, C.J., Murphy, K.J., Gasiunas, N., Harmer, N.J., Blundell, T.L., Pye, D.A., Gallagher, J.T., Evidence that heparin saccharides promote FGF2 mitogenesis through two distinct mechanisms (2008) J. Biol. Chem., 283, pp. 13001-13008
Soba, P., Homo- and heterodimerization of APP family members promotes intercellular adhesion (2005) EMBO J., 24, pp. 3624-3634
Menozzi, F. D., Bischoff, R., Fort, E., Brennan, M. J., Locht, C., Molecular characterization of the mycobacterial heparin-binding hemagglutinin, a mycobacterial adhesin (1998) Proc. Natl. Acad. Sci. USA, 95, pp. 12625-1263
Privalov, P. L., Stability of proteins: small globular proteins (1979) Adv. Protein Chem., 33, pp. 167-241
Zhou, Y., Hall, C. K., Karplus, M., The calorimetric criterion for a two-state process revisited (1999) Protein Sci., 8, pp. 1064-1074
Kleywegt, G. J., Jones, T. A., Model building and refinement practice (1997) Methods Enzymol., 277, pp. 208-230
Steinmetz, M. O., Molecular basis of coiled-coil formation (2007) Proc. Natl. Acad. Sci. USA, 104, pp. 7062-7067
Wolf, E., Kim, P. S., Berger, B., MultiCoil: a program for predicting two- and three-stranded coiled coils (1997) Protein Sci., 6, pp. 1179-1189
Jones, D. T., Taylor, W. R., Thornton, J. M., A model recognition approach to the prediction of all-helical membrane protein structure and topology (1994) Biochemistry, 33, pp. 3038-3049
McFarlane, A. A., Orriss, G. L., Stetefeld, J., The use of coiled-coil proteins in drug delivery systems (2009) Eur. J. Pharmacol., 625, pp. 101-107
Lee, D. L., Lavigne, P., Hodges, R. S., Are trigger sequences essential in the folding of two-stranded alpha-helical coiled-coils? (2001) J. Mol. Biol., 306, pp. 539-553
Goodger, S. J., Robinson, C. J., Murphy, K. J., Gasiunas, N., Harmer, N. J., Blundell, T. L., Pye, D. A., Gallagher, J. T., Evidence that heparin saccharides promote FGF2 mitogenesis through two distinct mechanisms (2008) J. Biol. Chem., 283, pp. 13001-13008
Febs Lett (ISSN: 0014-5793, 0014-5793print, 0014-5793linking), 2010 Mar 19; 584(6): 1091-1096.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 3.601, 5-year impact factor: 3.399
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-77950371492&partnerID=40&md5=4a68d914afd3f08f93e5a6c6c23bfff5
Keywords: Agglutination, Coiled Coil, Dimerisation, Stability, Tuberculosis, Heparin Binding Hemagglutinin Adhesin, Monomer, Protein, Unclassified Drug, Virulence Factor, Article, Cell Interaction, Controlled Study, Dimerization, Epithelium Cell, Experiment, Molecular Model, Molecular Stability, Mycobacterium Tuberculosis, Primary Infection, Priority Journal, Protein Conformation, Protein Denaturation, Protein Structure, Amino Acid Sequence, Antigens, Bacterial Adhesion, Lectins, Light, Molecular Sequence Data, Protein Folding, Protein Multimerization, Protein Stability, Scattering, Radiation, Temperature, Bacteria (microorganisms),
Affiliations:
*** IBB - CNR ***
Istitute of Biostructures and Bioimaging, C.N.R., I-80134 - Naples, Italy
Department of Chemistry Paolo Corradini, University of Naples Federico II, Complesso Universitario Monte S. Angelo, I-80126, Naples, Italy
Department of Biological and Environmental Sciences, University of Sannio, I-82100 Benevento, Italy
References:
Menozzi, F.D., Bischoff, R., Fort, E., Brennan, M.J., Locht, C., Molecular characterization of the mycobacterial heparin-binding hemagglutinin, a mycobacterial adhesin (1998) Proc. Natl. Acad. Sci. USA, 95, pp. 12625-1263
Pethe, K., Alonso, S., Biet, F., Delogu, G., Brennan, M.J., Locht, C., Menozzi, F.D., The heparin-binding haemagglutinin of M. tuberculosis is required for extrapulmonary dissemination (2001) Nature, 412, pp. 190-194
Pethe, K., Aumercier, M., Fort, E., Gatot, C., Locht, C., Menozzi, F.D., Characterization of the heparin-binding site of the mycobacterial heparin-binding hemagglutinin adhesin (2000) J. Biol. Chem., 275, pp. 14273-14280
Heise, T., Dersch, P., Identification of a domain in Yersinia virulence factor YadA that is crucial for extracellular matrix-specific cell adhesion and uptake (2006) Proc. Natl. Acad. Sci. USA, 103, pp. 3375-3380
Verbelen, C., Raze, D., Dewitte, F., Locht, C., Dufrene, Y.F., Single-molecule force spectroscopy of mycobacterial adhesin-adhesin interactions (2007) J. Bacteriol., 189, pp. 8801-8806
Esposito, C., Pethoukov, M.V., Svergun, D.I., Ruggiero, A., Pedone, C., Pedone, E., Berisio, R., Evidence for an elongated dimeric structure of heparin-binding hemagglutinin from Mycobacterium tuberculosis (2008) J. Bacteriol., 190, pp. 4749-4753
Barone, G., Del Vecchio, P., Fessas, D., Giancola, C., Graziano, G., (1992) J. Therm. Anal., 38, p. 2779
Privalov, P.L., Stability of proteins: small globular proteins (1979) Adv. Protein Chem., 33, pp. 167-241
Zhou, Y., Hall, C.K., Karplus, M., The calorimetric criterion for a two-state process revisited (1999) Protein Sci., 8, pp. 1064-1074
Kleywegt, G.J., Jones, T.A., Model building and refinement practice (1997) Methods Enzymol., 277, pp. 208-230
Van Der Spoel, D., Lindahl, E., Hess, B., Groenhof, G., Mark, A.E., Berendsen, H.J., GROMACS: fast, flexible, and free (2005) J. Comput. Chem., 26, pp. 1701-1718
Walshaw, J., Woolfson, D.N., Socket: a program for identifying and analysing coiled-coil motifs within protein structures (2001) J. Mol. Biol., 307, pp. 1427-1450
Steinmetz, M.O., Molecular basis of coiled-coil formation (2007) Proc. Natl. Acad. Sci. USA, 104, pp. 7062-7067
Wolf, E., Kim, P.S., Berger, B., MultiCoil: a program for predicting two- and three-stranded coiled coils (1997) Protein Sci., 6, pp. 1179-1189
Hofmann, K., Stoffel, W., TMbase - a database of membrane spanning proteins segments (1993) Biol. Chem. Hoppe-Seyler, 374, p. 166
Jones, D.T., Taylor, W.R., Thornton, J.M., A model recognition approach to the prediction of all-helical membrane protein structure and topology (1994) Biochemistry, 33, pp. 3038-3049
Kall, L., Krogh, A., Sonnhammer, E.L., Advantages of combined transmembrane topology and signal peptide prediction-the Phobius web server (2007) Nucleic Acids Res., 35, pp. W429-W432
Hoffmann, C., Leis, A., Niederweis, M., Plitzko, J.M., Engelhardt, H., Disclosure of the mycobacterial outer membrane: cryo-electron tomography and vitreous sections reveal the lipid bilayer structure (2008) Proc. Natl. Acad. Sci. USA, 105, pp. 3963-3967
Niederweis, M., Danilchanka, O., Huff, J., Hoffmann, C., Engelhardt, H., (2010), Mycobacterial outer membranes: in search of proteins. Trends Microbiol., in pressNewman, J.R., Wolf, E., Kim, P.S., A computationally directed screen identifying interacting coiled coils from Saccharomyces cerevisiae (2000) Proc. Natl. Acad. Sci. USA, 97, pp. 13203-13208
Hurme, R., Berndt, K.D., Normark, S.J., Rhen, M., A proteinaceous gene regulatory thermometer in Salmonella (1997) Cell, 90, pp. 55-64
McFarlane, A.A., Orriss, G.L., Stetefeld, J., The use of coiled-coil proteins in drug delivery systems (2009) Eur. J. Pharmacol., 625, pp. 101-107
Meier, M., Burkhard, P., Statistical analysis of intrahelical ionic interactions in alpha-helices and coiled coils (2006) J. Struct. Biol., 155, pp. 116-129
Lee, D.L., Lavigne, P., Hodges, R.S., Are trigger sequences essential in the folding of two-stranded alpha-helical coiled-coils? (2001) J. Mol. Biol., 306, pp. 539-553
Tan, K., Heparin-induced cis- and trans-dimerization modes of the thrombospondin-1 N-terminal domain (2008) J. Biol. Chem., 283, pp. 3932-3941
Goodger, S.J., Robinson, C.J., Murphy, K.J., Gasiunas, N., Harmer, N.J., Blundell, T.L., Pye, D.A., Gallagher, J.T., Evidence that heparin saccharides promote FGF2 mitogenesis through two distinct mechanisms (2008) J. Biol. Chem., 283, pp. 13001-13008
Soba, P., Homo- and heterodimerization of APP family members promotes intercellular adhesion (2005) EMBO J., 24, pp. 3624-3634
Menozzi, F. D., Bischoff, R., Fort, E., Brennan, M. J., Locht, C., Molecular characterization of the mycobacterial heparin-binding hemagglutinin, a mycobacterial adhesin (1998) Proc. Natl. Acad. Sci. USA, 95, pp. 12625-1263
Privalov, P. L., Stability of proteins: small globular proteins (1979) Adv. Protein Chem., 33, pp. 167-241
Zhou, Y., Hall, C. K., Karplus, M., The calorimetric criterion for a two-state process revisited (1999) Protein Sci., 8, pp. 1064-1074
Kleywegt, G. J., Jones, T. A., Model building and refinement practice (1997) Methods Enzymol., 277, pp. 208-230
Steinmetz, M. O., Molecular basis of coiled-coil formation (2007) Proc. Natl. Acad. Sci. USA, 104, pp. 7062-7067
Wolf, E., Kim, P. S., Berger, B., MultiCoil: a program for predicting two- and three-stranded coiled coils (1997) Protein Sci., 6, pp. 1179-1189
Jones, D. T., Taylor, W. R., Thornton, J. M., A model recognition approach to the prediction of all-helical membrane protein structure and topology (1994) Biochemistry, 33, pp. 3038-3049
McFarlane, A. A., Orriss, G. L., Stetefeld, J., The use of coiled-coil proteins in drug delivery systems (2009) Eur. J. Pharmacol., 625, pp. 101-107
Lee, D. L., Lavigne, P., Hodges, R. S., Are trigger sequences essential in the folding of two-stranded alpha-helical coiled-coils? (2001) J. Mol. Biol., 306, pp. 539-553
Goodger, S. J., Robinson, C. J., Murphy, K. J., Gasiunas, N., Harmer, N. J., Blundell, T. L., Pye, D. A., Gallagher, J. T., Evidence that heparin saccharides promote FGF2 mitogenesis through two distinct mechanisms (2008) J. Biol. Chem., 283, pp. 13001-13008
Dimerisation and structural integrity of Heparin Binding Hemagglutinin A from Mycobacterium tuberculosis: Implications for bacterial agglutination
Heparin Binding Hemagglutinin A (HBHA) is hitherto the sole virulence factor associated with tuberculosis dissemination from the lungs, the site of primary infection, to epithelial cells. We have previously reported the solution structure of HBHA, a dimeric and elongated molecule. Since oligomerisation of HBHA is associated with its ability to induce bacterial agglutination, we investigated this process using experimental and modelling techniques. We here identified a short segment of HBHA whose presence is mandatory for the stability of folded conformation, whose denaturation is a reversible two-state process. Our data suggest that agglutination-driven cell-cell interactions do not occur via association of HBHA monomers, nor via association of HBHA dimers and open the scenario to a possible trans-dimerisation process. © 2010 Federation of European Biochemical Societies.
Heparin Binding Hemagglutinin A (HBHA) is hitherto the sole virulence factor associated with tuberculosis dissemination from the lungs, the site of primary infection, to epithelial cells. We have previously reported the solution structure of HBHA, a dimeric and elongated molecule. Since oligomerisation of HBHA is associated with its ability to induce bacterial agglutination, we investigated this process using experimental and modelling techniques. We here identified a short segment of HBHA whose presence is mandatory for the stability of folded conformation, whose denaturation is a reversible two-state process. Our data suggest that agglutination-driven cell-cell interactions do not occur via association of HBHA monomers, nor via association of HBHA dimers and open the scenario to a possible trans-dimerisation process. © 2010 Federation of European Biochemical Societies.
Dimerisation and structural integrity of Heparin Binding Hemagglutinin A from Mycobacterium tuberculosis: Implications for bacterial agglutination
| ▼ Cell wall recognition events for biosensors development |
| ▼ Structural and functional studies of virulence factors in Mycobacterium tuberculosis infection |
Dimerisation and structural integrity of Heparin Binding Hemagglutinin A from Mycobacterium tuberculosis: Implications for bacterial agglutination
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Impact Factor: 14.1
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Calvanese L, Falcigno L, Maglione C, Marasco D, Ruggiero A, Squeglia F, Berisio R, D'Auria G
* Structural and binding properties of the PASTA domain of PonA2, a key penicillin binding protein from Mycobacterium tuberculosis (468 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2014 Jul; 101(7): 712-719.
Impact Factor: 2.385
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Romano M, Van De Weerd R, Brouwer FCC, Roviello GN, Lacroix R, Sparrius M, Van Den Brink-van Stempvoort G, Maaskant JJ, Van Der Sar AM, Appelmelk BJ, Geurtsen JJ, Berisio R
* Structure and function of RNase AS, a polyadenylate-specific exoribonuclease affecting mycobacterial virulence in vivo (375 views)
Structure (ISSN: 0969-2126, 1878-4186, 0969-2126linking), 2014 May 6; 22(5): 719-730.
Impact Factor: 5.618
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Dubbioso R, Pappata S, Quarantelli M, D'Arco F, Manganelli F, Esposito M, Santoro L
* Atypical Clinical And Radiological Presentation Of Cryptococcal Choroid Plexitis In An Immunocompetent Woman (380 views)
J Neurol Sci (ISSN: 1878-5883, 0022-510x), 2013 Nov; 334(1-2): 180-182.
Impact Factor: 1.453
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Correale S, Ruggiero A, Capparelli R, Pedone E, Berisio R
* Structures of free and inhibited forms of the L, D-transpeptidase LdtMt1 from Mycobacterium tuberculosis (398 views)
Acta Crystallogr D Biol Crystallogr (ISSN: 0907-4449, 0907-4449linking), 2013 Sep; 69(Pt9): 1697-1706.
Impact Factor: 7.232
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Squeglia F, Romano M, Ruggiero A, Vitagliano L, De Simone A, Berisio R
* Carbohydrate recognition by RpfB from mycobacterium tuberculosis unveiled by crystallographic and molecular dynamics analyses (471 views)
Biophysical Journal (ISSN: 0006-3495, 1542-0086), 2013 Jun 4; 104(11): 2530-2539.
Impact Factor: 3.832
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Correale S, Ruggiero A, Pedone E, Berisio R
* Expression, purification, crystallization and preliminary X-ray crystallographic analysis of the l, d-transpeptidase LdtMt1 from Mycobacterium tuberculosis (404 views)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1744-3091, 1744-4309), 2013 Mar 1; 69(3): 253-256.
Impact Factor: 0.568
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Ruggiero A, Marchant J, Squeglia F, Makarov V, De Simone A, Berisio R
* Molecular determinants of inactivation of the resuscitation promoting factor B from Mycobacterium tuberculosis (408 views)
J Biomol Struct Dyn (ISSN: 0739-1102, 1538-0254electronic, 0739-1102linking), 2013 Feb 1; 31(2): 195-205.
Impact Factor: 2.983
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Kaprelyants AS, Mukamolova GV, Ruggiero A, Makarov VA, Demina GR, Shleeva MO, Potapov VD, Shramko PA
* Resuscitation-promoting Factors (Rpf): In Search of Inhibitors (496 views)
Protein Pept Lett (ISSN: 0929-8665, 1875-5305), 2012 Oct; 19(10): 1026-1034.
Impact Factor: 1.994
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Esposito C, Cantisani M, D'Auria G, Falcigno L, Pedone E, Galdiero S, Berisio R
* Mapping key interactions in the dimerization process of HBHA from Mycobacterium tuberculosis, insights into bacterial agglutination (461 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 2012 Mar 23; 586(6): 659-667.
Impact Factor: 3.582
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Castellano I, Merlino A
* γ-glutamyltranspeptidases: Sequence, structure, biochemical properties, and biotechnological applications (422 views)
Cell Mol Life Sci (ISSN: 1420-682x), 2012; 69(20): 3381-3394.
Impact Factor: 5.615
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Esposito C, Marasco D, Delogu G, Pedone E, Berisio R
* Heparin-binding hemagglutinin HBHA from Mycobacterium tuberculosis affects actin polymerisation (346 views)
Biochem Biophys Res Commun (ISSN: 0006-291x), 2011 Jul 1; 410(2): 339-344.
Impact Factor: 2.484
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Ruggiero A, Squeglia F, Pirone L, Correale S, Berisio R
* Expression, purification, crystallization and preliminary X-ray crystallographic analysis of a major fragment of the resuscitation-promoting factor RpfB from Mycobacterium tuberculosis (407 views)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1744-3091, 1744-4309), 2011 Jan 1; 67(1): 164-168.
Impact Factor: 0.506
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D'Auria G, Esposito C, Falcigno L, Calvanese L, Iaccarino E, Ruggiero A, Pedone C, Pedone E, Berisio R
* Dynamical properties of cold shock protein A from Mycobacterium tuberculosis (321 views)
Biochem Biophys Res Commun (ISSN: 0006-291x, 1090-2104, 1090-2104electronic), 2010 Nov 26; 402(4): 693-698.
Impact Factor: 2.595
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Ruggiero A, Marasco D, Squeglia F, Soldini S, Pedone E, Pedone C, Berisio R
* Structure and functional regulation of RipA, a mycobacterial enzyme essential for daughter cell separation (419 views)
Structure (ISSN: 0969-2126, 1878-4186, 0969-2126linking), 2010 Sep 8; 18(9): 1184-1190.
Impact Factor: 6.337
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Leone M, Barile E, Vazquez J, Mei A, Guiney D, Dahl R, Pellecchia M
* NMR-based design and evaluation of novel bidentate inhibitors of the protein tyrosine phosphatase YopH (519 views)
Chem Biol Drug Des (ISSN: 1747-0277, 1747-0285), 2010 Jul; 76(1): 10-16.
Impact Factor: 2.527
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Ruggiero A, Squeglia F, Esposito C, Marasco D, Pedone E, Pedone C, Berisio R
* Expression, purification, crystallization and preliminary X-ray crystallographic analysis of the resuscitation promoting factor interacting protein RipA from M. tuberculosis (348 views)
Protein Pept Lett (ISSN: 0929-8665, 1875-5305), 2010 Jan; 17(1): 70-73.
Impact Factor: 1.849
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Ruggiero A, Tizzano B, Pedone E, Pedone C, Wilmanns M, Berisio R
* Crystal Structure of the Resuscitation-Promoting Factor (Delta DUF)RpfB from M. tuberculosis (571 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2009 Jan 9; 385(1): 153-162.
Impact Factor: 3.871
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Esposito C, Pethoukov MV, Svergun DI, Ruggiero A, Pedone C, Pedone E, Berisio R
* Evidence for an elongated dimeric structure of heparin-binding hemagglutinin from Mycobacterium tuberculosis (460 views)
J Bacteriol Journal Of Bacteriology (ISSN: 0021-9193, 1098-5530), 2008 Jul; 190(13): 4749-4753.
Impact Factor: 3.636
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Ruggiero A, Tizzano B, Geerlof A, Pedone E, Pedone C, Wilmanns M, Berisio R
* Expression, purification, crystallization and preliminary X-ray crystallographic analysis of a resuscitation-promoting factor from Mycobacterium tuberculosis (387 views)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1744-3091, 1744-4309), 2007 Oct 1; 63(10): 870-873.
Impact Factor: 0.645
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* The Potential Role of Vaccines in Preventing Antimicrobial Resistance (AMR): An Update and Future Perspectives (5 views)
Vaccines, 2023 Feb; 11: 333-353.
Impact Factor: 4.961
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Berisio R, Delogu G
* PGRS domain structures: Doomed to sail the mycomembrane (11 views)
Plos Pathog (ISSN: 1553-7366linking), 2022 Sep 1; 18(9): e1010760-N/D.
Impact Factor: 7.5
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Ruggiero A, Choi HG, Barra G, Squeglia F, Back YW, Kim HJ, Berisio R
* Structure based design of effective HtpG-derived vaccine antigens against M. tuberculosis (4 views)
Front Mol Biosci (ISSN: 2296-889xlinking), 2022 Aug 11; 9: 964645-964645.
Impact Factor: 6.11
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Squeglia F, Marasco D, Ruggiero A, Testa G, Esposito L, Berisio R
* Structural and Binding Properties of the Active Cell Wall Hydrolase RipA from M. tuberculosis, a Promising Biosensing Molecule for Early Warning Bacterial Detection (5 views)
Curr Med Chem (ISSN: 0929-8673linking), 2022; 29(24): 4282-4292.
Impact Factor: 4.74
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De Maio F, Salustri A, Battah B, Palucci I, Marchionni F, Bellesi S, Palmieri V, Papi M, Kramarska E, Sanguinetti M, Sali M, Berisio R, Delogu G
* PE_PGRS3 ensures provision of the vital phospholipids cardiolipin and phosphatidylinositols by promoting the interaction between M. tuberculosis and host cells (28 views)
Virulence (ISSN: 2150-5594linking), 2021 Dec; 12(1): 868-884.
Impact Factor: 5.542
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Kramarska E, Squeglia F, De Maio F, Delogu G, Berisio R
* PE_PGRS33, an Important Virulence Factor of Mycobacterium tuberculosis and Potential Target of Host Humoral Immune Response (19 views)
Cells (ISSN: 2073-4409linking, 2073-4409electronic), 2021 Jan 15; 10(1): N/D-N/D.
Impact Factor: 6.6
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Moreira M, Ruggiero A, Esposito L, Choi HG, Kim HJ, Berisio R
* Structural features of HtpGMtb and HtpG-ESAT6Mtb vaccine antigens against tuberculosis: Molecular determinants of antigenic synergy and cytotoxicity modulation (122 views) (PDF 7 views)
Int J Biol Macromol (ISSN: 0141-8130linking, 1879-0003electronic), 2020 May 4; 158: 305-317.
Impact Factor: 6.95
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De Maio F, Berisio R, Manganelli R, Delogu G
* PE_PGRS proteins of Mycobacterium tuberculosis: A specialized molecular task force at the forefront of host-pathogen interaction (100 views)
Virulence, 2020; N/D: 898-915.
Impact Factor: 5.54
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Calvanese L, Squeglia F, Romano M, D'Auria G, Falcigno L, Berisio R
* Structural and dynamic studies provide insights into specificity and allosteric regulation of Ribonuclease AS, a key enzyme in mycobacterial virulence (216 views) (PDF 10 views)
J Biomol Struct Dyn (ISSN: 0739-1102linking, 1538-0254electronic), 2020; N/D: 1-19.
Impact Factor: 3.11
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Squeglia F, Moreira M, Ruggiero A, Berisio R
* The Cell Wall Hydrolytic NlpC/P60 Endopeptidases in Mycobacterial Cytokinesis: A Structural Perspective (217 views)
Cells (ISSN: 2073-4409linking, 2073-4409electronic), 2019 Jun 18; 8(6): N/D-N/D.
Impact Factor: 5.7
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De Maio F, Squeglia F, Goletti D, Delogu G
* The Mycobacterial HBHA Protein: a Promising Biomarker for Tuberculosis (208 views)
Curr Med Chem (ISSN: 0929-8673linking, 1875-533xelectronic), 2018 Oct 29; 26(11): 2051-2060.
Impact Factor: 3.519
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Squeglia F, Ruggiero A, Berisio R
* Collagen degradation in tuberculosis pathogenesis: the biochemical consequences of hosting an undesired guest (387 views)
Biochem J (ISSN: 1470-8728electronic, 0264-6021linking, 0264-6021print), 2018 Oct 11; 475(19): 3123-3140.
Impact Factor: 4.897
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Chino M, Zhang SQ, Pirro F, Leone L, Maglio O, Lombardi A, Degrado WF
* Spectroscopic and metal binding properties of a de novo metalloprotein binding a tetrazinc cluster (315 views)
Biopolymers (ISSN: 1097-0282electronic, 0006-3525linking, 0006-3525print), 2018 Sep 11; 109(10): e23339-e23339.
Impact Factor: 2.572
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Squeglia F, Ruggiero A, Berisio R
* Chemistry of Peptidoglycan in Mycobacterium tuberculosis Life Cycle: An off-the-wall Balance of Synthesis and Degradation (103 views)
Chemistry (ISSN: 0947-6539linking, 1521-3765electronic), 2018 Feb 21; 24 (11 ): 2533-2546.
Impact Factor: 5.476
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Squeglia F, Ruggiero A, De Simone A, Berisio R
* A structural overview of mycobacterial adhesins: Key biomarkers for diagnostics and therapeutics (258 views)
Protein Sci (ISSN: 1469-896xelectronic, 0961-8368linking), 2018 Feb; 27(2): 369-380.
Impact Factor: 2.523
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Squeglia F, Ruggiero A, Berisio R
* Chemistry of Peptidoglycan in Mycobacterium tuberculosis life style: an off-the-wall balance of synthesis and degradation (479 views) (PDF 221 views)
Chemistry (ISSN: 1521-3765electronic, 0947-6539linking), 2018; 24: 2533-2546.
Impact Factor: 5.317
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Berisio R, Squeglia F, Ruggiero A
* Editorial: Molecular Scenarios Behind Infectious Diseases (315 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2017 Nov 24; 24(36): 3939-3941.
Impact Factor: 3.469
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Squeglia F, Romano M, Ruggiero A, Berisio R
* Molecular players in Tuberculosis drug development: another break in the cell wall (321 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2017 Nov 24; 24(36): 3954-3969.
Impact Factor: 3.469
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Ruggiero A, Squeglia F, Romano M, Vitagliano L, De Simone A, Berisio R
* Structure and dynamics of the multi-domain resuscitation promoting factor RpfB from Mycobacterium tuberculosis (359 views)
J Biomol Struct Dyn (ISSN: 0739-1102, 1538-0254electronic, 0739-1102linking), 2017 May; 35(6): 1322-1330.
Impact Factor: 3.107
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Ruggiero A, Squeglia F, Romano M, Vitagliano L, De Simone A, Berisio R
* The structure of Resuscitation promoting factor B from M. tuberculosis reveals unexpected ubiquitin-like domains (328 views)
Bba-Gen Subjects (ISSN: 0005-2728, 0006-3002print, 1570-9639print), 2015 Nov 5; 1860(2): 445-451.
Impact Factor: 4.864
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Romano M, Squeglia F, Berisio R
* Structure and Function of RNase AS, a Novel Virulence Factor from Mycobacterium Tuberculosis (402 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2015 Apr 17; 22(14): 1745-1756.
Impact Factor: 3.455
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Squeglia F, Ruggiero A, Berisio R
* Exit from mycobacterial dormancy: a structural perspective (396 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2015 Feb 9; 22(14): 1698-1709.
Impact Factor: 3.455
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Morra F, Luise C, Visconti R, Staibano S, Merolla F, Ilardi G, Guggino G, Paladino S, Sarnataro D, Franco R, Monaco R, Zitomarino F, Pacelli R, Monaco G, Rocco G, Cerrato A, Linardopoulos S, Muller MT, Celetti A
* New therapeutic perspectives in CCDC6 deficient lung cancer cells (462 views)
Int J Cancer (ISSN: 0020-7136), 2015; 136(9): 2146-2157.
Impact Factor: 5.531
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Squeglia F, Ruggiero A, Romano M, Vitagliano L, Berisio R
* Mutational and structural study of RipA, a key enzyme in Mycobacterium tuberculosis cell division: Evidence for the l-to-d inversion of configuration of the catalytic cysteine (455 views)
Acta Crystallogr D Biol Crystallogr (ISSN: 0907-4449, 0907-4449linking), 2014 Sep; 70(9): 2295-2300.
Impact Factor: 14.1
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Calvanese L, Falcigno L, Maglione C, Marasco D, Ruggiero A, Squeglia F, Berisio R, D'Auria G
* Structural and binding properties of the PASTA domain of PonA2, a key penicillin binding protein from Mycobacterium tuberculosis (468 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2014 Jul; 101(7): 712-719.
Impact Factor: 2.385
View Export to BibTeX Export to EndNote
Romano M, Van De Weerd R, Brouwer FCC, Roviello GN, Lacroix R, Sparrius M, Van Den Brink-van Stempvoort G, Maaskant JJ, Van Der Sar AM, Appelmelk BJ, Geurtsen JJ, Berisio R
* Structure and function of RNase AS, a polyadenylate-specific exoribonuclease affecting mycobacterial virulence in vivo (375 views)
Structure (ISSN: 0969-2126, 1878-4186, 0969-2126linking), 2014 May 6; 22(5): 719-730.
Impact Factor: 5.618
View Export to BibTeX Export to EndNote
Dubbioso R, Pappata S, Quarantelli M, D'Arco F, Manganelli F, Esposito M, Santoro L
* Atypical Clinical And Radiological Presentation Of Cryptococcal Choroid Plexitis In An Immunocompetent Woman (380 views)
J Neurol Sci (ISSN: 1878-5883, 0022-510x), 2013 Nov; 334(1-2): 180-182.
Impact Factor: 1.453
View Export to BibTeX Export to EndNote
Correale S, Ruggiero A, Capparelli R, Pedone E, Berisio R
* Structures of free and inhibited forms of the L, D-transpeptidase LdtMt1 from Mycobacterium tuberculosis (398 views)
Acta Crystallogr D Biol Crystallogr (ISSN: 0907-4449, 0907-4449linking), 2013 Sep; 69(Pt9): 1697-1706.
Impact Factor: 7.232
View Export to BibTeX Export to EndNote
Squeglia F, Romano M, Ruggiero A, Vitagliano L, De Simone A, Berisio R
* Carbohydrate recognition by RpfB from mycobacterium tuberculosis unveiled by crystallographic and molecular dynamics analyses (471 views)
Biophysical Journal (ISSN: 0006-3495, 1542-0086), 2013 Jun 4; 104(11): 2530-2539.
Impact Factor: 3.832
View Export to BibTeX Export to EndNote
Correale S, Ruggiero A, Pedone E, Berisio R
* Expression, purification, crystallization and preliminary X-ray crystallographic analysis of the l, d-transpeptidase LdtMt1 from Mycobacterium tuberculosis (404 views)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1744-3091, 1744-4309), 2013 Mar 1; 69(3): 253-256.
Impact Factor: 0.568
View Export to BibTeX Export to EndNote
Ruggiero A, Marchant J, Squeglia F, Makarov V, De Simone A, Berisio R
* Molecular determinants of inactivation of the resuscitation promoting factor B from Mycobacterium tuberculosis (408 views)
J Biomol Struct Dyn (ISSN: 0739-1102, 1538-0254electronic, 0739-1102linking), 2013 Feb 1; 31(2): 195-205.
Impact Factor: 2.983
View Export to BibTeX Export to EndNote
Kaprelyants AS, Mukamolova GV, Ruggiero A, Makarov VA, Demina GR, Shleeva MO, Potapov VD, Shramko PA
* Resuscitation-promoting Factors (Rpf): In Search of Inhibitors (496 views)
Protein Pept Lett (ISSN: 0929-8665, 1875-5305), 2012 Oct; 19(10): 1026-1034.
Impact Factor: 1.994
View Export to BibTeX Export to EndNote
Esposito C, Cantisani M, D'Auria G, Falcigno L, Pedone E, Galdiero S, Berisio R
* Mapping key interactions in the dimerization process of HBHA from Mycobacterium tuberculosis, insights into bacterial agglutination (461 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 2012 Mar 23; 586(6): 659-667.
Impact Factor: 3.582
View Export to BibTeX Export to EndNote
Castellano I, Merlino A
* γ-glutamyltranspeptidases: Sequence, structure, biochemical properties, and biotechnological applications (422 views)
Cell Mol Life Sci (ISSN: 1420-682x), 2012; 69(20): 3381-3394.
Impact Factor: 5.615
View Export to BibTeX Export to EndNote
Esposito C, Marasco D, Delogu G, Pedone E, Berisio R
* Heparin-binding hemagglutinin HBHA from Mycobacterium tuberculosis affects actin polymerisation (346 views)
Biochem Biophys Res Commun (ISSN: 0006-291x), 2011 Jul 1; 410(2): 339-344.
Impact Factor: 2.484
View Export to BibTeX Export to EndNote
Ruggiero A, Squeglia F, Pirone L, Correale S, Berisio R
* Expression, purification, crystallization and preliminary X-ray crystallographic analysis of a major fragment of the resuscitation-promoting factor RpfB from Mycobacterium tuberculosis (407 views)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1744-3091, 1744-4309), 2011 Jan 1; 67(1): 164-168.
Impact Factor: 0.506
View Export to BibTeX Export to EndNote
D'Auria G, Esposito C, Falcigno L, Calvanese L, Iaccarino E, Ruggiero A, Pedone C, Pedone E, Berisio R
* Dynamical properties of cold shock protein A from Mycobacterium tuberculosis (321 views)
Biochem Biophys Res Commun (ISSN: 0006-291x, 1090-2104, 1090-2104electronic), 2010 Nov 26; 402(4): 693-698.
Impact Factor: 2.595
View Export to BibTeX Export to EndNote
Ruggiero A, Marasco D, Squeglia F, Soldini S, Pedone E, Pedone C, Berisio R
* Structure and functional regulation of RipA, a mycobacterial enzyme essential for daughter cell separation (419 views)
Structure (ISSN: 0969-2126, 1878-4186, 0969-2126linking), 2010 Sep 8; 18(9): 1184-1190.
Impact Factor: 6.337
View Export to BibTeX Export to EndNote
Leone M, Barile E, Vazquez J, Mei A, Guiney D, Dahl R, Pellecchia M
* NMR-based design and evaluation of novel bidentate inhibitors of the protein tyrosine phosphatase YopH (519 views)
Chem Biol Drug Des (ISSN: 1747-0277, 1747-0285), 2010 Jul; 76(1): 10-16.
Impact Factor: 2.527
View Export to BibTeX Export to EndNote
Ruggiero A, Squeglia F, Esposito C, Marasco D, Pedone E, Pedone C, Berisio R
* Expression, purification, crystallization and preliminary X-ray crystallographic analysis of the resuscitation promoting factor interacting protein RipA from M. tuberculosis (348 views)
Protein Pept Lett (ISSN: 0929-8665, 1875-5305), 2010 Jan; 17(1): 70-73.
Impact Factor: 1.849
View Export to BibTeX Export to EndNote
Ruggiero A, Tizzano B, Pedone E, Pedone C, Wilmanns M, Berisio R
* Crystal Structure of the Resuscitation-Promoting Factor (Delta DUF)RpfB from M. tuberculosis (571 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2009 Jan 9; 385(1): 153-162.
Impact Factor: 3.871
View Export to BibTeX Export to EndNote
Esposito C, Pethoukov MV, Svergun DI, Ruggiero A, Pedone C, Pedone E, Berisio R
* Evidence for an elongated dimeric structure of heparin-binding hemagglutinin from Mycobacterium tuberculosis (460 views)
J Bacteriol Journal Of Bacteriology (ISSN: 0021-9193, 1098-5530), 2008 Jul; 190(13): 4749-4753.
Impact Factor: 3.636
View Export to BibTeX Export to EndNote
Ruggiero A, Tizzano B, Geerlof A, Pedone E, Pedone C, Wilmanns M, Berisio R
* Expression, purification, crystallization and preliminary X-ray crystallographic analysis of a resuscitation-promoting factor from Mycobacterium tuberculosis (387 views)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1744-3091, 1744-4309), 2007 Oct 1; 63(10): 870-873.
Impact Factor: 0.645
View Export to BibTeX Export to EndNote
43 Records (43 excluding Abstracts).
Total impact factor: 182.219 (182.219 excluding Abstracts).
Total 5 year impact factor: 167.136 (167.136 excluding Abstracts).
Total impact factor: 182.219 (182.219 excluding Abstracts).
Total 5 year impact factor: 167.136 (167.136 excluding Abstracts).
494 views. Last view on Saturday 14 January 2023, 18:56:14
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