Keywords: Antibody, Ca Ix, Ca Xii, Carbonic Anhydrase (ca), Coumarin, Enzyme Selective Inhibition, Hypoxia, Phenol, Sulfonamides, Tumor Acidification, Tumor Imaging, Tumorigenesis, X-Ray Crystallography, Acetazolamide, Carbonate Dehydratase Inhibitor, Carbonate Dehydratase Xii, Clioquinol, Coumarin Derivative, Imatinib, Nilotinib, Thiocoumarin, Unclassified Drug, Article, Cancer Cell, Carcinogenesis, Cell Growth, Diagnostic Procedure, Drug Design, Drug Inhibition, Drug Targeting, Enzyme Inhibition, Enzyme Structure, Protein Expression, Antigens, Neoplasm, Antineoplastic Agents, Carbonic Anhydrase Inhibitors, Humans,
Affiliations: *** IBB - CNR ***
Balikesir University Science and Art Faculty Department of Chemistry/Biochemistry division, Cagis yerleskesi /Kampus, Balikesir, Turkey
Istituto di Biostrutture e Bioimmagini-CNR, via Mezzocannone 16, 80134 Naples, Italy
Polo Scientifico, Laboratorio di Chimica Bioinorganica, Università degli Studi di Firenze, 188, Via della Lastruccia 3, 50019 Sesto Fiorentino, Florence, Italy
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Ahlskog, J.K., Schliemann, C., Mårlind, J., Qureshi, U., Ammar, A., Pedleym, R.B., Neri, D., Human monoclonal antibodies targeting carbonic anhydrase IX for the molecular imaging of hypoxic regions in solid tumours (2009) Br. J. Cancer, 101, pp. 645-657
Supuran, C. T., Carbonic anhydrases: Novel therapeutic applications for inhibitors and activators (2008) Nat. Rev. Drug Discov, 7, pp. 168-18
Supuran, C. T., Scozzafava, A., Conway, J., (2004) Carbonic Anhydrase-Its Inhibitors and Activators, pp. 1-363. , CRC Press: Boca Raton, New York, London
Pastorekova, P. S., Pastorek, J., Supuran, C. T., Carbonic anhydrases: Current state of the art, therapeutic applications and future prospects (2004) J. Enz. Inhib. Med. Chem, 19, pp. 199-229
Kivel, A. J., Parkkila, S., Saarnio, J., Karttunen, T. J., Kivel, J., Parkkila, A. K., Pastorekov, S., Rajaniemi, H., Expression of the membrane-associated carbonic anhydrase isozyme XII in the human kidney and renal tumors (2000) Histochem. Cell Biol, 114, pp. 197-204
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Harris, A. L. Hypoxia-inducible Expression of Tumor-associated Carbonic Anhydrases. Cancer Res, 60, pp. 7075-7083
Brahimi-Horn, M. C., Pouyss gur, J., Hypoxia in cancer cell metabolism and pH regulation (2007) Essays Biochem, 43, pp. 165-178
Kaelin Jr., W. G., Ratcliffe, P. J., Oxygen sensing by metazoans: The central role of the HIF hydroxylase pathway (2008) Mol. Cell, 30, pp. 393-402
Vastov, E., Hulikov, A., Rafajov, M., Zat'Ovi ov, M., Gibadulinov, A., Casini, A., Cecchi, A., Pastorek, J., Hypoxia activates the capacity of tumor-associated carbonic anhydrase IX to acidify extracellular pH (2004) FEBS Lett, 577, pp. 439-445
Ivanov, S. V., Kuzmin, I., Wei, M. H., Pack, S., Geil, L., Johnson, B. E., Stanbridge, E. J., Lerman, M. I., Down-regulation of transmembrane carbonic anhydrases in renal cell carcinoma cell lines by wild-type von Hippel-Lindau transgenes (1998) Proc. Natl. Acad. Sci. USA, 95, pp. 12596-12601
Whittington, D. A., Grubb, J. H., Waheed, A., Shah, G. N., Sly, W. S., Christianson, D. W., Crystal structure of the dimeric extracellular domain of human carbonic anhydrase XII, a bitopic membrane protein overexpressed in certain cancer tumor cells (2001) Proc. Natl. Acad. Sci. USA, 98, pp. 9545-9559
Supuran, C. T., Briganti, F., Tilli, S., Chegwidden, W. R., Scozzafava, A., Carbonic anhydrase inhibitors: Sulfonamides as antitumor agents? (2001) Bioorg. Med. Chem, 9, pp. 703-714
Supuran, C. T., Indisulaman anticancer sulfonamide in clinical development (2003) Expert Opin. Investig. Drugs, 12, pp. 283-287
Thiry, A., Dogn, J. -M., Masereel, B., Supuran, C. T., Targeting tumor-associated carbonic anhydrase IX in cancer therapy (2006) Trends Pharmacol. Sci, 27, pp. 566-573
Winum, J. Y., Rami, M., Scozzafava, A., Montero, J. L., Supuran, C., Carbonic Anhydrase IX: A new druggable target for the design of antitumor agents (2008) Med. Res. Rev, 28, pp. 445-463
zensoy, O., Puccetti, L., Fasolis, G., Arslan, O., Scozzafava, A., Supuran, C. T., Carbonic anhydrase inhibitors. Inhibition of the tumor associated isozymes IX and XII with a library of aromatic and heteroaromatic sulfonamide (2005) Bioorg. Med. Chem. Lett, 15, pp. 4862-4866
Wilkinson, B. L., Bornaghi, L. F., Houston, T. A., Innocenti, A., Supuran, C. T., Poulsen, S. -A., A novel class of carbonic anhydrase inhibitors: Glycoconjugate benzene sulfonamides prepared by "click-tailing" (2006) J. Med. Chem, 49, pp. 6539-6548
Ilies, M. A., Vullo, D., Pastorek, J., Scozzafava, A., Ilies, M., Caproiu, M. T., Pastorekova, S., Supuran, C. T., Carbonic anhydrase inhibitors. Inhibition of tumor-associated isozyme IX with halogenosulfanilamide and halogenophenylaminobenzolamide derivatives (2003) J. Med. Chem, 46, pp. 2187-2196
Winum, J. -Y., Vullo, D., Casini, A., Montero, J. -L., Scozzafava, A., Supuran, C. T., Carbonic anhydrase inhibitors: Inhibition of cytosolic isozymes I and II and the transmembrane, tumor-associated isozyme IX with sulfamates including EMATE also acting as steroid sulfatase inhibitors (2003) J. Med. Chem, 46, pp. 2197-2204
Supuran, C. T., Development of small molecule carbonic anhydrase IX inhibitors (2008) BJU Int, 101, pp. 39-40
Winum, J. Y., Temperini, C., El Cheikh, K., Innocenti, A., Vullo, D., Ciattini, S., Montero, J. L., Supuran, C. T., Carbonic anhydrase inhibitors: Clash with Ala65 as a means for designing inhibitors with low affinity for the ubiquitous isozyme II, exemplified by the crystal structure of the topiramate sulfamide analogue (2006) J. Med. Chem, 49, pp. 7024-7031
Colinas, P. A., Bravo, R. D., Vullo, D., Scozzafava, A., Supuran, C. T., Carbonic anhydrase inhibitors. Inhibition of cytosolic isoforms I and II, and extracellular isoforms IV, IX and XII with sulfamides incorporating sugar moieties (2007) Bioorg. Med. Chem. Lett, 17, pp. 5086-5090
Ahlskog, J. K. J., Dumelin, C. E., Tr ssel, S., Marlind, J., Neri, D., In vivo targeting of tumor-associated carbonic anhydrases using acetazolamide derivatives (2009) Bioorg. Med. Chem. Lett, 19, pp. 4851-4856
Ahlskog, J. K., Schliemann, C., M rlind, J., Qureshi, U., Ammar, A., Pedleym, R. B., Neri, D., Human monoclonal antibodies targeting carbonic anhydrase IX for the molecular imaging of hypoxic regions in solid tumours (2009) Br. J. Cancer, 101, pp. 645-657
Drug design studies of the novel antitumor targets carbonic anhydrase IX and XII
Ntziachristos V, Cuénod CA, Fournier L, Balvay D, Pradel C, Siauve N, Clement O, Jouannot E, Lucidarme O, Vecchio SD, Salvatore M, Law B, Tung C-H, Jain RK, Fukumura D, Munn LL, Brown EB, Schellenberger E, Montet X, Weissleder R, Clerck ND, Postnov A * Tumor Imaging(350 views) Textbook Of In Vivo Imaging In Vertebrates (ISSN: 9780-4700), 2007 Jul 16; 1: 277-309. Impact Factor:1.148 ViewExport to BibTeXExport to EndNote