Elevated Expression of the Tyrosine Phosphatase SHP-1 Defines a Subset of High-Grade Breast Tumors(449 views) Insabato L, Amelio I, Quarto M, Zannetti A, Tolino F, De Mauro G, Cerchia L, Riccio P, Baumhoer D, Condorelli G, Terracciano L, De Franciscis V
Keywords: Breast Cancer, Clinical Setting, Shp-1, Tissue Microarray, Tyrosine Phosphatase, Core Protein, Epidermal Growth Factor Receptor 2, Estrogen Receptor, Protein Bcl 2, Protein Tyrosine Phosphatase Shp 1, Tumor Marker, Cyclin Dependent Kinase Inhibitor 2a, Ptpn6 Protein, Human, Article, Breast Tumor, Clinical Article, Controlled Study, Disease Association, Human Cell, Human Tissue, Immunohistochemistry, Priority Journal, Prognosis, Protein Analysis, Protein Expression, Cell Proliferation, Enzymology, Female, Mortality, Pathology, Proto Oncogene, Tumor Cell Line, Breast Neoplasms, Cyclin-Dependent Kinase Inhibitor P16, Non-Receptor Type 6,
Affiliations: *** IBB - CNR ***
Biomorphological and Functional Science, Anatomic Pathology Section, Faculty of Medicine, Italy
Dipartimento Scienze Fisiche, Italy
Dipartimento di Biologia e Patologia Cellulare e Molecolare, Università Degli Studi di Napoli Federico II, Italy
Istituto di Endocrinologia Ed Oncologia Sperimentale, CNR, Via S. Pansini 5, IT-80131 Naples, Italy
Istituto di Biostrutture e Bioimmagini, CNR, Napoli, Italy
Institute of Pathology, University Hospital, Basel, Switzerland
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Elevated Expression of the Tyrosine Phosphatase SHP-1 Defines a Subset of High-Grade Breast Tumors
Objectives: Protein tyrosine phosphatases are key regulators of intracellular signaling that contribute to determining cancer cell growth, which thus makes them attractive targets for therapeutic and diagnostic agents. SHP-1 phosphotyrosine phosphatase is rarely expressed in epithelial tumor cells, but expression has been found in several breast cancer cell lines and tumors. To determine the potential significance of SHP-1 as a prognostic marker in the clinical setting, we examined SHP-1 protein expression in breast tumors. Methods: We analyzed SHP-1 expression by immunohistochemistry in a breast tissue microarray composed of 2,081 cores, either alone or in combination with known prognostic markers. Results: Our data showed that SHP-1 expression was confined to a well-defined subset of high-grade tumors characterized by unique biological parameters. SHP-1 expression correlated directly with expression of the tyrosine kinase receptor HER-2 and inversely with expression of the estrogen receptor, while it was weakly associated with Bcl-2 expression. Conclusions: Levels of SHP-1 were correlated with conventional pathologic parameters of tumor aggressiveness and were associated with reduced patient survival, suggesting that elevated expression of SHP-1 is a common molecular abnormality in a defined subset of breast tumors and might be used in routine diagnosis to identify patients with high-risk tumors. Copyright (C) 2010 S. Karger AG, Basel
Elevated Expression of the Tyrosine Phosphatase SHP-1 Defines a Subset of High-Grade Breast Tumors
Cusanno F, Cisbani E, Colilli S, Fratoni R, Garibaldi F, Giuliani F, Gricia M, Lucentini M, Magliozzi ML, Santarivenere F, Torrioli S, Cinti MN, Pani R, Pellegrini R, Simonetti G, Schillaci O, Del Vecchio S, Salvatore M, Majewski S, De Vincentis G, Scopinaro F * Results of clinical trials with SPEM(278 views) Nucl Instrum Methods Phys Res Sect A, 2007 Feb 1; 497(1): 46-50. Impact Factor:3.221 ViewExport to BibTeXExport to EndNote