Exofacial protein thiols as a route for the internalization of Gd(III)-based complexes for magnetic resonance imaging cell labeling(455 views) Digilio G, Menchise V, Gianolio E, Catanzaro V, Carrera C, Napolitano R, Fedeli F, Aime S
Keywords: Gadolinium, Gadolinium Chelate, Thiol, Article, Cell Culture, Cell Labeling, Endosome, Human, Human Cell, Internalization, Molecular Probe, Nuclear Magnetic Resonance Imaging, Structure Analysis, Animals, Chelating Agents, Contrast Media, Glioma, K562 Cells, Magnetic Resonance Spectroscopy, Melanoma, Experimental, Mice, Organometallic Compounds, Proteins, Spectrophotometry, Ultraviolet, Sulfhydryl Compounds, Chelating Agents Chemical Synthesis Chemistry Pharmacokinetics, Contrast Media Chemical Synthesis Chemistry Pharmacokinetics, Gadolinium Chemistry, Glioma Metabolism, Magnetic Resonance Imaging Methods, Experimental Metabolism, Organometallic Compounds Chemical Synthesis Chemistry Pharmacokinetics, Proteins Chemistry Metabolism, Sulfhydryl Compounds Chemistry Metabolism,
Affiliations: *** IBB - CNR ***
Department of Environmental and Life Sciences, University of Eastern Piedmont A. Avogadro, Viale T. Michel 11, I-15121 Alessandria, Italy
Institute for Biostructures and Bioimages (CNR), C/o Molecular Biotechnology Center, University of Turin, Via Nizza 52, I-10125 Torino, Italy
Department of Chemisty, IFM and Center for Molecular Imaging, University of Turin, Via Nizza 52, I-10125 Torino, Italy
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(2007) Molecular and Cellular MR-Imaging, , Modo, M. M. J. J.
Pathak, A. P., Gimi, B., Glunde, K., Ackerstaff, E., Artemov, D., Bhujwalla, Z. M., Molecular and functional imaging of cancer: Advances in MRI and MRS (2004) Methods Enzymol., 386, pp. 3-60
Muller, R. N., Roch, A., Colet, J. -M., Ouaksim, A., Gillis, P., Particulate Magnetic Constrast Agents (2001) The Chemistry of Contrast Agents in Medical Magnetic Resonance Imaging, pp. 417-435. , Merbach, A. E.
Bulte, J. W. M., Kraitchman, D. L., Iron oxide MR contrast agents for molecular and cellular imaging (2004) NMR Biomed., 17, pp. 484-499
Wiener, E. C., Konda, S., Shadron, A., Brechbiel, M., Gansow, O., Targeting dendrimer-chelates to tumors and tumor cells expressing the high-affinity folate receptor (1997) Invest. Radiol., 32, pp. 748-754
Strijkers, G. J., Hak, S., Kok, M. B., Springer, C. S., Nicolay, K., Three-compartment T 1 relaxation model for intracellular paramagnetic contrast agents (2009) Magn. Reson. Med., 61, pp. 1049-1058
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Jiang, X. -M., Fitzgerald, M., Grant, C. M., Hogg, P. J., Redox control of exofacial protein thiols/disulfides by protein disulfide isomerase (1999) J. Biol. Chem., 274, pp. 2416-2423
Anelli, P. S., Fedeli, F., Gazzotti, O., Lattuada, L., Lux, G., Rebasti, F., L -Glutamic acid and l -lysine as useful building blocks for the preparation of bifunctional DTPA-like ligands (1999) Bioconjugate Chem., 10, pp. 137-140
Powell, D. H., Ni Dhubhghaill, O. M., Pubanz, D., Helm, L., Lebedev, Y. S., Schlaepfer, W., Merbach, A. E., Structural and dynamic parameters obtained from O-17 NMR, EPR, and NMRD studies of monomeric and dimeric Gd3+ complexes of interest in magnetic resonance imaging: An integrated and theoretically self consistent approach (1996) J. Am. Chem. Soc., 118, pp. 9333-9346
Hogg, P. J., Disulfide bonds as switches for protein function (2003) Trends Biochem. Sci., 28, pp. 211-214
Go, Y. -M., Jones, D. P., Intracellular proatherogenic events and cell adhesion modulated by extracellular thiol/disulfide redox state (2005) Circulation, 111, pp. 2973-2980
Bradford, M. M., A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding (1976) Anal. Biochem., 72, pp. 248-254
Exofacial protein thiols as a route for the internalization of Gd(III)-based complexes for magnetic resonance imaging cell labeling
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