Exploring the catalytic mechanism of the first dimeric Bcp: Functional, structural and docking analyses of Bcp4 from Sulfolobus solfataricus (373 views)
Biochimie (ISSN: 1638-6183, 0300-9084, 1638-6183electronic), 2010 Oct; 92(10): 1435-1444.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 3.787, 5-year impact factor: 3.728
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-77957105568&partnerID=40&md5=c88420ee3e7cf166ac13bee07a5b279b
Keywords: Bacterioferritin Comigratory Proteins, Disulfide Bond, Peroxiredoxin, Protein Disulfide Oxidoreductase, Sulfolobus Solfataricus, Bacterial Protein, Mutant Protein, Unclassified Drug, Article, Biocatalysis, Biochemistry, Comparative Study, Crystal Structure, Molecular Docking, Nonhuman, Protein Analysis, Protein Function, Protein Motif, Protein Protein Interaction, Protein Structure, Reaction Analysis, Site Directed Mutagenesis, Structure Analysis, X Ray Crystallography, Antioxidants, X-Ray, Mutation, Oxidation-Reduction, Protein Binding, Protein Multimerization,
Affiliations:
*** IBB - CNR ***
Dipartimento di Biologia Strutturale e Funzionale, Universita degli Studi di Napoli ''Federico II'', Complesso Universitario Monte S. Angelo, Via Cinthia, 80126 Naples, Italy.
Istituto di Biostrutture e Bioimmagini-CNR, Via Mezzocannone 16, 80134 Naples, Italy
References:
Imlay, J.A., Pathways of oxidative damage (2003) Annu. Rev. Microbiol., 57, pp. 395-41
Poole, L.B., The catalytic mechanism of peroxiredoxins (2007) Subcell. Biochem., 44, pp. 61-68
Wood, Z.A., Schröder, E., Harris, J.R., Poole, L.B., Structure, mechanisms and regulation of peroxiredoxins (2003) Trends Biochem. Sci., 28, pp. 32-40
Djordjević, V.B., Free radicals in cell biology (2004) Int. Rev. Cytol., 237, pp. 57-89
Bryk, R., Griffin, P., Nathan, C., Peroxynitrite reductase activity of bacterial peroxiredoxins (2000) Nature, 407, pp. 211-215
Winterbourn, C.C., Hampton, M.B., Thiol chemistry and specificity in redox signaling (2008) Free Radic. Biol. Med., 45, pp. 549-561
Neumann, C.A., Krause, D.S., Carman, C.V., Das, S., Dubey, D.P., Abraham, J.L., Bronson, R.T., Van Etten, R.A., Essential role for the peroxiredoxin Prdx1 in erythrocyte antioxidant defence and tumour suppression (2003) Nature, 424, pp. 561-565
Wood, Z.A., Poole, L.B., Karplus, P.A., Peroxiredoxin evolution and the regulation of hydrogen peroxide signalling (2003) Science, 300, pp. 592-594
Limauro, D., Pedone, E., Pirone, L., Bartolucci, S., Identification and characterization of 1-Cys peroxiredoxin from Sulfolobus solfataricus and its involvement in the response to oxidative stress (2006) FEBS J., 273, pp. 721-731
Deponte, M., Rahlfs, S., Becker, K., Peroxiredoxin systems of protozoal parasites (2007) Subcell. Biochem., 44, pp. 219-429
Choi, M.H., Lee, I.K., Kim, G.W., Kim, B.U., Han, Y.H., Yu, D.Y., Park, H.S., Kang, S.W., Regulation of PDGF- signaling and vascular remodeling by peroxiredoxin II (2005) Nature, 435, pp. 47-353
Cha, M.K., Hong, S.K., Kim, I.H., Four thiol peroxidases contain a conserved GCT catalytic motif and act as a versatile array of lipid peroxidases in Anabaena sp. PCC7120 (2007) Free Radic. Biol. Med., 42, pp. 1736-1748
Clarke, D.J., Mackay, C.L., Campopiano, D.J., Langridge-Smith, P., Brown, A.R., Interrogating the molecular details of the peroxiredoxin activity of the Escherichia coli bacterioferritin comigratory protein using high-resolution mass spectrometry (2009) Biochemistry, 48, pp. 3904-3914
Rho, B.S., Hung, L.W., Holton, J.M., Vigil, D., Kim, S.I., Park, M.S., Terwilliger, T.C., Pedelacq, J.D., Functional and structural characterization of a thiol peroxidase from Mycobacterium tuberculosis (2006) J. Mol. Biol., 361, pp. 850-863
Jeon, S.J., Ishikawa, K., Characterization of novel hexadecameric thioredoxin peroxidase from Aeropyrum pernix K1 (2003) J. Biol. Chem., 278, pp. 24174-24180
D'Ambrosio, K., Limauro, D., Pedone, E., Galdi, I., Pedone, C., Bartolucci, S., De Simone, G., Insights into the catalytic mechanism of the bcp family: functional and structural analysis of Bcp1 from Sulfolobus solfataricus (2009) Proteins, 76, pp. 95-1006
Jeong, W., Cha, M.K., Kim, I.H., Thioredoxin-dependent hydroperoxide peroxidase activity of bacterioferritin comigratory protein (BCP) as a new member of the thiol-specific antioxidant protein (TSA)/Alkyl hydroperoxide peroxidase C (AhpC) family (2000) J. Biol. Chem., 275, pp. 2924-2930
Rouhier, N., Gelhaye, E., Gualberto, J.M., Jordy, M.N., De Fay, E., Hirasawa, M., Duplessis, S., Jacquot, J.P., Poplar peroxiredoxin Q. A thioredoxin-linked chloroplast antioxidant functional in pathogen defense (2004) Plant Physiol, 134, pp. 1027-1038
Choi, J., Choi, S., Chon, J.K., Choi, J., Cha, M.K., Kim, I.H., Shin, W., Crystal structure of the C107S/C112S mutant of yeast nuclear 2-Cys peroxiredoxin (2005) Proteins, 61, pp. 1146-1149
Wakita, M., Masuda, S., Motohashi, K., Hisabori, T., Ohta, H., Takamiya, K., The significance of type II and PrxQ peroxiredoxins for antioxidative stress response in the purple bacterium Rhodobacter sphaeroides (2007) J. Biol. Chem., 282, pp. 27792-27801
Limauro, D., Saviano, M., Galdi, I., Rossi, M., Bartolucci, S., Pedone, E., Sulfolobus solfataricus protein disulphide oxidoreductase: insight into the roles of its redox sites (2009) Protein Eng. Des. Sel., 22, pp. 19-26
McPherson, A., Current approaches to macromolecular crystallization (1990) Eur. J. Biochem., 189, pp. 1-23
Cudney, R., Patel, S., Weisgraber, K., Newhouse, Y., McPherson, A., Screening and optimization strategies for macromolecular crystal growth (1994) Acta Crystallogr. Sect. D, 50, pp. 414-423
Jancarik, J., Kim, S.H., Sparse matrix sampling: a screening method for crystallisation of proteins (1991) J. Appl. Cryst., 24, pp. 409-411
Otwinowsky, Z., Minor, W., Processing of X-Ray diffraction data collected in oscillation mode (1997) Meth. Enzymol., 276, pp. 307-326
Brünger, A.T., Adams, P.D., Clore, G.M., DeLano, W.L., Gros, P., Grosse-Kunsteleve, R.W., Jiang, J.S., Warren, G.L., Crystallography and NMR system (CNS): a new software system for macromolecular structure determination (1998) Acta Crystallogr. Sect. D, 54, pp. 905-921
Jones, T.A., Zou, J.Y., Cowan, S.W., Kjeldgaard, M., Improved methods for building protein models in electron density maps and the location of errors in these models (1991) Acta Crystallogr. Sect. A, 47, pp. 110-119
D'Ambrosio, K., Pedone, E., Langella, E., De Simone, G., Rossi, M., Pedone, C., Bartolucci, S., A novel member of the protein disulfide oxidoreductase family from Aeropyrum pernix K1: structure, function and electrostatics (2006) J. Mol. Biol., 362, pp. 743-752
Schwede, T., Kopp, J., Guex, N., Peitsch, M.C., SWISS-MODEL: an automated protein homology-modeling server (2003) Nucleic Acids Res, 31, pp. 3381-3385
Altschul, S.F., Madden, T.L., Schäffer, A.A., Zhang, J., Zhang, Z., Miller, W., Lipman, D.J., Gapped BLAST and PSI-BLAST: a new generation of protein database search programs (1997) Nucleic Acids Res, 25, pp. 389-3402
Chen, R., Li, L., Weng, Z., ZDOCK: an initial-stage protein-docking algorithm (2003) Proteins, 52, pp. 80-87
Koradi, R., Billeter, M., Wüthrich, K., MOLMOL: a program for display and analysis of macromolecular structures (1996) J. Mol. Graph., 14, pp. 51-55
Reynolds, C., Damerell, D., Jones, S., ProtorP: a protein-protein interaction analysis server (2009) Bioinformatics, 25, pp. 413-414
Laskowsky, R.A., MacArthur, M.W., Moss, D.S., Thornton, J.M., PROCHECK: a program to check the stereochemical quality of protein structures (1993) J. Appl. Cryst., 26, pp. 283-329
Choi, H.J., Kang, S.W., Yang, C.H., Rhee, S.G., Ryu, S.E., Crystal structure of a novel human peroxidase enzyme at 2.0 Å resolution (1998) Nat. Struct. Biol., 5, pp. 400-406
Declercq, J.P., Evrard, C., Clippe, A., Vander Stricht, D., Bernard, A., Knoops, B., Crystal structure of human peroxiredoxin 5, a novel type of Mammalian peroxiredoxin at 1.5 Å resolution (2001) J. Mol. Biol., 311, pp. 751-759
Hirotsu, S., Abe, Y., Okada, K., Nagahara, N., Hori, H., Nishino, T.S., Hakoshima, T., Crystal structure of a multifunctional 2-Cys peroxiredoxin heme-binding protein23kDa/proliferation associated gene product (1999) Proc. Natl. Acad. Sci. USA, 96, pp. 12333-12338
Li, S., Peterson, N.A., Kim, M.Y., Kim, C.Y., Hung, L.W., Yu, M., Lekin, T., Baker, E.N., Crystal structure of AhpE from Mycobacterium tuberculosis, a 1-Cys peroxiredoxin (2005) J. Mol. Biol., 346, pp. 1035-1046
Sarma, G.N., Nickel, C., Rahlfs, S., Fischer, M., Becker, K., Karplus, P.A., Crystal structure of a novel Plasmodium falciparum 1-Cys peroxiredoxin (2005) J. Mol. Biol., 346, pp. 1021-1034
Koh, C.S., Didierjean, C., Navrot, N., Panjikar, S., Mulliert, G., Rouhier, N., Jacquot, J.P., Corbier, C., Crystal structures of a poplar thioredoxin peroxidase that exhibits the structure of glutathione peroxidases: insights into redox-driven conformational changes (2007) J. Mol. Biol., 370, pp. 512-529
Imlay, J. A., Pathways of oxidative damage (2003) Annu. Rev. Microbiol., 57, pp. 395-41
Poole, L. B., The catalytic mechanism of peroxiredoxins (2007) Subcell. Biochem., 44, pp. 61-68
Wood, Z. A., Schr der, E., Harris, J. R., Poole, L. B., Structure, mechanisms and regulation of peroxiredoxins (2003) Trends Biochem. Sci., 28, pp. 32-40
Djordjevi, V. B., Free radicals in cell biology (2004) Int. Rev. Cytol., 237, pp. 57-89
Winterbourn, C. C., Hampton, M. B., Thiol chemistry and specificity in redox signaling (2008) Free Radic. Biol. Med., 45, pp. 549-561
Neumann, C. A., Krause, D. S., Carman, C. V., Das, S., Dubey, D. P., Abraham, J. L., Bronson, R. T., Van Etten, R. A., Essential role for the peroxiredoxin Prdx1 in erythrocyte antioxidant defence and tumour suppression (2003) Nature, 424, pp. 561-565
Wood, Z. A., Poole, L. B., Karplus, P. A., Peroxiredoxin evolution and the regulation of hydrogen peroxide signalling (2003) Science, 300, pp. 592-594
Choi, M. H., Lee, I. K., Kim, G. W., Kim, B. U., Han, Y. H., Yu, D. Y., Park, H. S., Kang, S. W., Regulation of PDGF- signaling and vascular remodeling by peroxiredoxin II (2005) Nature, 435, pp. 47-353
Cha, M. K., Hong, S. K., Kim, I. H., Four thiol peroxidases contain a conserved GCT catalytic motif and act as a versatile array of lipid peroxidases in Anabaena sp. PCC7120 (2007) Free Radic. Biol. Med., 42, pp. 1736-1748
Clarke, D. J., Mackay, C. L., Campopiano, D. J., Langridge-Smith, P., Brown, A. R., Interrogating the molecular details of the peroxiredoxin activity of the Escherichia coli bacterioferritin comigratory protein using high-resolution mass spectrometry (2009) Biochemistry, 48, pp. 3904-3914
Rho, B. S., Hung, L. W., Holton, J. M., Vigil, D., Kim, S. I., Park, M. S., Terwilliger, T. C., Pedelacq, J. D., Functional and structural characterization of a thiol peroxidase from Mycobacterium tuberculosis (2006) J. Mol. Biol., 361, pp. 850-863
Jeon, S. J., Ishikawa, K., Characterization of novel hexadecameric thioredoxin peroxidase from Aeropyrum pernix K1 (2003) J. Biol. Chem., 278, pp. 24174-24180
Jeong, W., Cha, M. K., Kim, I. H., Thioredoxin-dependent hydroperoxide peroxidase activity of bacterioferritin comigratory protein (BCP) as a new member of the thiol-specific antioxidant protein (TSA) /Alkyl hydroperoxide peroxidase C (AhpC) family (2000) J. Biol. Chem., 275, pp. 2924-2930
Br nger, A. T., Adams, P. D., Clore, G. M., DeLano, W. L., Gros, P., Grosse-Kunsteleve, R. W., Jiang, J. S., Warren, G. L., Crystallography and NMR system (CNS): a new software system for macromolecular structure determination (1998) Acta Crystallogr. Sect. D, 54, pp. 905-921
Jones, T. A., Zou, J. Y., Cowan, S. W., Kjeldgaard, M., Improved methods for building protein models in electron density maps and the location of errors in these models (1991) Acta Crystallogr. Sect. A, 47, pp. 110-119
Altschul, S. F., Madden, T. L., Sch ffer, A. A., Zhang, J., Zhang, Z., Miller, W., Lipman, D. J., Gapped BLAST and PSI-BLAST: a new generation of protein database search programs (1997) Nucleic Acids Res, 25, pp. 389-3402
Laskowsky, R. A., MacArthur, M. W., Moss, D. S., Thornton, J. M., PROCHECK: a program to check the stereochemical quality of protein structures (1993) J. Appl. Cryst., 26, pp. 283-329
Choi, H. J., Kang, S. W., Yang, C. H., Rhee, S. G., Ryu, S. E., Crystal structure of a novel human peroxidase enzyme at 2. 0 resolution (1998) Nat. Struct. Biol., 5, pp. 400-406
Declercq, J. P., Evrard, C., Clippe, A., Vander Stricht, D., Bernard, A., Knoops, B., Crystal structure of human peroxiredoxin 5, a novel type of Mammalian peroxiredoxin at 1. 5 resolution (2001) J. Mol. Biol., 311, pp. 751-759
Sarma, G. N., Nickel, C., Rahlfs, S., Fischer, M., Becker, K., Karplus, P. A., Crystal structure of a novel Plasmodium falciparum 1-Cys peroxiredoxin (2005) J. Mol. Biol., 346, pp. 1021-1034
Koh, C. S., Didierjean, C., Navrot, N., Panjikar, S., Mulliert, G., Rouhier, N., Jacquot, J. P., Corbier, C., Crystal structures of a poplar thioredoxin peroxidase that exhibits the structure of glutathione peroxidases: insights into redox-driven conformational changes (2007) J. Mol. Biol., 370, pp. 512-529
Biochimie (ISSN: 1638-6183, 0300-9084, 1638-6183electronic), 2010 Oct; 92(10): 1435-1444.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 3.787, 5-year impact factor: 3.728
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-77957105568&partnerID=40&md5=c88420ee3e7cf166ac13bee07a5b279b
Keywords: Bacterioferritin Comigratory Proteins, Disulfide Bond, Peroxiredoxin, Protein Disulfide Oxidoreductase, Sulfolobus Solfataricus, Bacterial Protein, Mutant Protein, Unclassified Drug, Article, Biocatalysis, Biochemistry, Comparative Study, Crystal Structure, Molecular Docking, Nonhuman, Protein Analysis, Protein Function, Protein Motif, Protein Protein Interaction, Protein Structure, Reaction Analysis, Site Directed Mutagenesis, Structure Analysis, X Ray Crystallography, Antioxidants, X-Ray, Mutation, Oxidation-Reduction, Protein Binding, Protein Multimerization,
Affiliations:
*** IBB - CNR ***
Dipartimento di Biologia Strutturale e Funzionale, Universita degli Studi di Napoli ''Federico II'', Complesso Universitario Monte S. Angelo, Via Cinthia, 80126 Naples, Italy.
Istituto di Biostrutture e Bioimmagini-CNR, Via Mezzocannone 16, 80134 Naples, Italy
References:
Imlay, J.A., Pathways of oxidative damage (2003) Annu. Rev. Microbiol., 57, pp. 395-41
Poole, L.B., The catalytic mechanism of peroxiredoxins (2007) Subcell. Biochem., 44, pp. 61-68
Wood, Z.A., Schröder, E., Harris, J.R., Poole, L.B., Structure, mechanisms and regulation of peroxiredoxins (2003) Trends Biochem. Sci., 28, pp. 32-40
Djordjević, V.B., Free radicals in cell biology (2004) Int. Rev. Cytol., 237, pp. 57-89
Bryk, R., Griffin, P., Nathan, C., Peroxynitrite reductase activity of bacterial peroxiredoxins (2000) Nature, 407, pp. 211-215
Winterbourn, C.C., Hampton, M.B., Thiol chemistry and specificity in redox signaling (2008) Free Radic. Biol. Med., 45, pp. 549-561
Neumann, C.A., Krause, D.S., Carman, C.V., Das, S., Dubey, D.P., Abraham, J.L., Bronson, R.T., Van Etten, R.A., Essential role for the peroxiredoxin Prdx1 in erythrocyte antioxidant defence and tumour suppression (2003) Nature, 424, pp. 561-565
Wood, Z.A., Poole, L.B., Karplus, P.A., Peroxiredoxin evolution and the regulation of hydrogen peroxide signalling (2003) Science, 300, pp. 592-594
Limauro, D., Pedone, E., Pirone, L., Bartolucci, S., Identification and characterization of 1-Cys peroxiredoxin from Sulfolobus solfataricus and its involvement in the response to oxidative stress (2006) FEBS J., 273, pp. 721-731
Deponte, M., Rahlfs, S., Becker, K., Peroxiredoxin systems of protozoal parasites (2007) Subcell. Biochem., 44, pp. 219-429
Choi, M.H., Lee, I.K., Kim, G.W., Kim, B.U., Han, Y.H., Yu, D.Y., Park, H.S., Kang, S.W., Regulation of PDGF- signaling and vascular remodeling by peroxiredoxin II (2005) Nature, 435, pp. 47-353
Cha, M.K., Hong, S.K., Kim, I.H., Four thiol peroxidases contain a conserved GCT catalytic motif and act as a versatile array of lipid peroxidases in Anabaena sp. PCC7120 (2007) Free Radic. Biol. Med., 42, pp. 1736-1748
Clarke, D.J., Mackay, C.L., Campopiano, D.J., Langridge-Smith, P., Brown, A.R., Interrogating the molecular details of the peroxiredoxin activity of the Escherichia coli bacterioferritin comigratory protein using high-resolution mass spectrometry (2009) Biochemistry, 48, pp. 3904-3914
Rho, B.S., Hung, L.W., Holton, J.M., Vigil, D., Kim, S.I., Park, M.S., Terwilliger, T.C., Pedelacq, J.D., Functional and structural characterization of a thiol peroxidase from Mycobacterium tuberculosis (2006) J. Mol. Biol., 361, pp. 850-863
Jeon, S.J., Ishikawa, K., Characterization of novel hexadecameric thioredoxin peroxidase from Aeropyrum pernix K1 (2003) J. Biol. Chem., 278, pp. 24174-24180
D'Ambrosio, K., Limauro, D., Pedone, E., Galdi, I., Pedone, C., Bartolucci, S., De Simone, G., Insights into the catalytic mechanism of the bcp family: functional and structural analysis of Bcp1 from Sulfolobus solfataricus (2009) Proteins, 76, pp. 95-1006
Jeong, W., Cha, M.K., Kim, I.H., Thioredoxin-dependent hydroperoxide peroxidase activity of bacterioferritin comigratory protein (BCP) as a new member of the thiol-specific antioxidant protein (TSA)/Alkyl hydroperoxide peroxidase C (AhpC) family (2000) J. Biol. Chem., 275, pp. 2924-2930
Rouhier, N., Gelhaye, E., Gualberto, J.M., Jordy, M.N., De Fay, E., Hirasawa, M., Duplessis, S., Jacquot, J.P., Poplar peroxiredoxin Q. A thioredoxin-linked chloroplast antioxidant functional in pathogen defense (2004) Plant Physiol, 134, pp. 1027-1038
Choi, J., Choi, S., Chon, J.K., Choi, J., Cha, M.K., Kim, I.H., Shin, W., Crystal structure of the C107S/C112S mutant of yeast nuclear 2-Cys peroxiredoxin (2005) Proteins, 61, pp. 1146-1149
Wakita, M., Masuda, S., Motohashi, K., Hisabori, T., Ohta, H., Takamiya, K., The significance of type II and PrxQ peroxiredoxins for antioxidative stress response in the purple bacterium Rhodobacter sphaeroides (2007) J. Biol. Chem., 282, pp. 27792-27801
Limauro, D., Saviano, M., Galdi, I., Rossi, M., Bartolucci, S., Pedone, E., Sulfolobus solfataricus protein disulphide oxidoreductase: insight into the roles of its redox sites (2009) Protein Eng. Des. Sel., 22, pp. 19-26
McPherson, A., Current approaches to macromolecular crystallization (1990) Eur. J. Biochem., 189, pp. 1-23
Cudney, R., Patel, S., Weisgraber, K., Newhouse, Y., McPherson, A., Screening and optimization strategies for macromolecular crystal growth (1994) Acta Crystallogr. Sect. D, 50, pp. 414-423
Jancarik, J., Kim, S.H., Sparse matrix sampling: a screening method for crystallisation of proteins (1991) J. Appl. Cryst., 24, pp. 409-411
Otwinowsky, Z., Minor, W., Processing of X-Ray diffraction data collected in oscillation mode (1997) Meth. Enzymol., 276, pp. 307-326
Brünger, A.T., Adams, P.D., Clore, G.M., DeLano, W.L., Gros, P., Grosse-Kunsteleve, R.W., Jiang, J.S., Warren, G.L., Crystallography and NMR system (CNS): a new software system for macromolecular structure determination (1998) Acta Crystallogr. Sect. D, 54, pp. 905-921
Jones, T.A., Zou, J.Y., Cowan, S.W., Kjeldgaard, M., Improved methods for building protein models in electron density maps and the location of errors in these models (1991) Acta Crystallogr. Sect. A, 47, pp. 110-119
D'Ambrosio, K., Pedone, E., Langella, E., De Simone, G., Rossi, M., Pedone, C., Bartolucci, S., A novel member of the protein disulfide oxidoreductase family from Aeropyrum pernix K1: structure, function and electrostatics (2006) J. Mol. Biol., 362, pp. 743-752
Schwede, T., Kopp, J., Guex, N., Peitsch, M.C., SWISS-MODEL: an automated protein homology-modeling server (2003) Nucleic Acids Res, 31, pp. 3381-3385
Altschul, S.F., Madden, T.L., Schäffer, A.A., Zhang, J., Zhang, Z., Miller, W., Lipman, D.J., Gapped BLAST and PSI-BLAST: a new generation of protein database search programs (1997) Nucleic Acids Res, 25, pp. 389-3402
Chen, R., Li, L., Weng, Z., ZDOCK: an initial-stage protein-docking algorithm (2003) Proteins, 52, pp. 80-87
Koradi, R., Billeter, M., Wüthrich, K., MOLMOL: a program for display and analysis of macromolecular structures (1996) J. Mol. Graph., 14, pp. 51-55
Reynolds, C., Damerell, D., Jones, S., ProtorP: a protein-protein interaction analysis server (2009) Bioinformatics, 25, pp. 413-414
Laskowsky, R.A., MacArthur, M.W., Moss, D.S., Thornton, J.M., PROCHECK: a program to check the stereochemical quality of protein structures (1993) J. Appl. Cryst., 26, pp. 283-329
Choi, H.J., Kang, S.W., Yang, C.H., Rhee, S.G., Ryu, S.E., Crystal structure of a novel human peroxidase enzyme at 2.0 Å resolution (1998) Nat. Struct. Biol., 5, pp. 400-406
Declercq, J.P., Evrard, C., Clippe, A., Vander Stricht, D., Bernard, A., Knoops, B., Crystal structure of human peroxiredoxin 5, a novel type of Mammalian peroxiredoxin at 1.5 Å resolution (2001) J. Mol. Biol., 311, pp. 751-759
Hirotsu, S., Abe, Y., Okada, K., Nagahara, N., Hori, H., Nishino, T.S., Hakoshima, T., Crystal structure of a multifunctional 2-Cys peroxiredoxin heme-binding protein23kDa/proliferation associated gene product (1999) Proc. Natl. Acad. Sci. USA, 96, pp. 12333-12338
Li, S., Peterson, N.A., Kim, M.Y., Kim, C.Y., Hung, L.W., Yu, M., Lekin, T., Baker, E.N., Crystal structure of AhpE from Mycobacterium tuberculosis, a 1-Cys peroxiredoxin (2005) J. Mol. Biol., 346, pp. 1035-1046
Sarma, G.N., Nickel, C., Rahlfs, S., Fischer, M., Becker, K., Karplus, P.A., Crystal structure of a novel Plasmodium falciparum 1-Cys peroxiredoxin (2005) J. Mol. Biol., 346, pp. 1021-1034
Koh, C.S., Didierjean, C., Navrot, N., Panjikar, S., Mulliert, G., Rouhier, N., Jacquot, J.P., Corbier, C., Crystal structures of a poplar thioredoxin peroxidase that exhibits the structure of glutathione peroxidases: insights into redox-driven conformational changes (2007) J. Mol. Biol., 370, pp. 512-529
Imlay, J. A., Pathways of oxidative damage (2003) Annu. Rev. Microbiol., 57, pp. 395-41
Poole, L. B., The catalytic mechanism of peroxiredoxins (2007) Subcell. Biochem., 44, pp. 61-68
Wood, Z. A., Schr der, E., Harris, J. R., Poole, L. B., Structure, mechanisms and regulation of peroxiredoxins (2003) Trends Biochem. Sci., 28, pp. 32-40
Djordjevi, V. B., Free radicals in cell biology (2004) Int. Rev. Cytol., 237, pp. 57-89
Winterbourn, C. C., Hampton, M. B., Thiol chemistry and specificity in redox signaling (2008) Free Radic. Biol. Med., 45, pp. 549-561
Neumann, C. A., Krause, D. S., Carman, C. V., Das, S., Dubey, D. P., Abraham, J. L., Bronson, R. T., Van Etten, R. A., Essential role for the peroxiredoxin Prdx1 in erythrocyte antioxidant defence and tumour suppression (2003) Nature, 424, pp. 561-565
Wood, Z. A., Poole, L. B., Karplus, P. A., Peroxiredoxin evolution and the regulation of hydrogen peroxide signalling (2003) Science, 300, pp. 592-594
Choi, M. H., Lee, I. K., Kim, G. W., Kim, B. U., Han, Y. H., Yu, D. Y., Park, H. S., Kang, S. W., Regulation of PDGF- signaling and vascular remodeling by peroxiredoxin II (2005) Nature, 435, pp. 47-353
Cha, M. K., Hong, S. K., Kim, I. H., Four thiol peroxidases contain a conserved GCT catalytic motif and act as a versatile array of lipid peroxidases in Anabaena sp. PCC7120 (2007) Free Radic. Biol. Med., 42, pp. 1736-1748
Clarke, D. J., Mackay, C. L., Campopiano, D. J., Langridge-Smith, P., Brown, A. R., Interrogating the molecular details of the peroxiredoxin activity of the Escherichia coli bacterioferritin comigratory protein using high-resolution mass spectrometry (2009) Biochemistry, 48, pp. 3904-3914
Rho, B. S., Hung, L. W., Holton, J. M., Vigil, D., Kim, S. I., Park, M. S., Terwilliger, T. C., Pedelacq, J. D., Functional and structural characterization of a thiol peroxidase from Mycobacterium tuberculosis (2006) J. Mol. Biol., 361, pp. 850-863
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Exploring the catalytic mechanism of the first dimeric Bcp: Functional, structural and docking analyses of Bcp4 from Sulfolobus solfataricus
The detoxification from peroxides in Sulfolobus solfataricus is performed by the Bacterioferritin comigratory proteins (Bcps), Bcp1 (Sso2071), Bcp2 (Sso2121), Bcp3 (Sso2255) and Bcp4 (Sso2613), antioxidant enzymes belonging to one of the subfamilies of the Peroxiredoxins. In this paper we report on the functional, structural and docking analyses of Bcp4, characterized by the CXXXXC motif in the active site. Bcp4 represents the first dimeric Bcp so far investigated. Biochemical studies showed that the protein has a non-covalent dimeric structure and adopts an atypical 2-Cys catalytic mechanism. The X-ray structure of the double mutant C45S/C50S, representative of the fully reduced enzyme state, described the protein dimeric arrangement. Finally, concurrent availability of the crystallographic structure of the monomeric Bcp1 allowed comparative analysis of the interaction with Protein Disulfide Oxidoreductase SsPDO (Sso0192), involved in the reduction of both Bcp1 and Bcp4, through a protein-protein docking approach. Copyright 2010 Elsevier Masson SAS. All rights reserved.
The detoxification from peroxides in Sulfolobus solfataricus is performed by the Bacterioferritin comigratory proteins (Bcps), Bcp1 (Sso2071), Bcp2 (Sso2121), Bcp3 (Sso2255) and Bcp4 (Sso2613), antioxidant enzymes belonging to one of the subfamilies of the Peroxiredoxins. In this paper we report on the functional, structural and docking analyses of Bcp4, characterized by the CXXXXC motif in the active site. Bcp4 represents the first dimeric Bcp so far investigated. Biochemical studies showed that the protein has a non-covalent dimeric structure and adopts an atypical 2-Cys catalytic mechanism. The X-ray structure of the double mutant C45S/C50S, representative of the fully reduced enzyme state, described the protein dimeric arrangement. Finally, concurrent availability of the crystallographic structure of the monomeric Bcp1 allowed comparative analysis of the interaction with Protein Disulfide Oxidoreductase SsPDO (Sso0192), involved in the reduction of both Bcp1 and Bcp4, through a protein-protein docking approach. Copyright 2010 Elsevier Masson SAS. All rights reserved.
Exploring the catalytic mechanism of the first dimeric Bcp: Functional, structural and docking analyses of Bcp4 from Sulfolobus solfataricus
| ▼ Structural characterization of proteins and enzymes isolated from organisms living under unusual conditions |
Exploring the catalytic mechanism of the first dimeric Bcp: Functional, structural and docking analyses of Bcp4 from Sulfolobus solfataricus
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Merlino A, Graziano G, Mazzarella L
* Structural And Dynamic Effects Of Alpha-Helix Deletion In Sso7d: Implications For Protein Thermal Stability (375 views)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2004 Dec 1; 57(4): 692-701.
Impact Factor: 4.429
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D'Ambrosio K, De Simone G, Pedone E, Rossi M, Bartolucci S, Pedone C
* Crystallization and preliminary X-ray diffraction studies of a protein disulfide oxidoreductase from Aquifex aeolicus (354 views)
Acta Crystallogr D Biol Crystallogr (ISSN: 0907-4449, 0907-4449linking), 2004 Nov; 60(11): 2076-2077.
Impact Factor: 1.693
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Sica F, Di Fiore A, Merlino A, Mazzarella L
* Structure and stability of the non-covalent swapped dimer of bovine seminal ribonuclease - An enzyme tailored to evade ribonuclease protein inhibitor (443 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2004 Sep 27; 279(35): 36753-36760.
Impact Factor: 6.355
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Pedone E, Bartolucci S, Fiorentino G
* Sensing and adapting to environmental stress: The Archaeal tactic (327 views)
Frontiers In Bioscience (ISSN: 1093-9946, 1093-4715), 2004 Sep 1; 9: 2909-2926.
Impact Factor: 3.226
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Pedone E, Ren B, Ladenstein R, Rossi M, Bartolucci S
* Functional properties of the protein disulfide oxidoreductase from the archaeon Pyrococcus furiosus - A member of a novel protein family related to protein disulfide-isomerase (375 views)
Eur J Biochem (ISSN: 0014-2956, 0014-2956print), 2004 Sep; 271(16): 3437-3448.
Impact Factor: 3.26
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Merlino A, Vitagliano L, Sica F, Zagari A, Mazzarella L
* Population shift vs induced fit: The case of bovine seminal ribonuclease swapping dimer (383 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2004 Apr 15; 73(6): 689-695.
Impact Factor: 2.863
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Vitagliano L, Ruggiero A, Masullo M, Cantiello P, Arcari P, Zagari A
* The Crystal Structure Of Sulfolobus Solfataricus Elongation Factor 1 Alpha In Complex With Magnesium And Gdp (478 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2004; 43(21): 6630-6636.
Impact Factor: 4.008
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Esposito L, Bruno I, Sica F, Raia CA, Giordano A, Rossi M, Mazzarella L, Zagari A
* Crystal structure of a ternary complex of the alcohol dehydrogenase from Sulfolobus solfataricus (499 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2003 Dec 16; 42(49): 14397-14407.
Impact Factor: 3.922
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Sica F, Di Fiore A, Zagari A, Mazzarella L
* The unswapped chain of bovine seminal ribonuclease: Crystal structure of the free and liganded monomeric derivative (340 views)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2003 Sep 1; 52(2): 263-271.
Impact Factor: 4.313
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Esposito L, Bruno I, Sica F, Raia CA, Giordano A, Rossi M, Mazzarella L, Zagari A
* Structural study of a single-point mutant of Sulfolobus solfataricus alcohol dehydrogenase with enhanced activity (313 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 2003 Mar 27; 539(1-3): 14-18.
Impact Factor: 3.609
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Esposito L, Sica F, Raia CA, Giordano A, Rossi M, Mazzarella L, Zagari A
* Crystal Structure Of The Alcohol Dehydrogenase From The Hyperthermophilic Archaeon Sulfolobus Solfataricus At 1. 85 Angstrom Resolution (435 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2002 Apr 26; 318(2): 463-477.
Impact Factor: 5.359
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Masullo M, Cantiello P, Paola B, Fiengo A, Vitagliano L, Zagari A, Arcari P
* Valine114 Replacements In The Archaeal Elongation Factor 1a Enhanced Its Ability To Interact With Aminoacyl-Trna And Kirromycin (352 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2002; 41(49): 14482-14488.
Impact Factor: 4.064
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Vitagliano L, Masullo M, Sica F, Zagari A, Bocchini V
* The crystal structure of Sulfolobus solfataricus elongation factor 1α in complex with GDP reveals novel features in nucleotide binding and exchange (452 views)
Embo J (ISSN: 0261-4189, 0261-4189linking), 2001 Oct 1; 20(19): 5305-5311.
Impact Factor: 12.459
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Orru S, Vitagliano L, Esposito L, Mazzarella L, Marino G, Ruoppolo M
Effect of deamidation on folding of ribonuclease (385 views)
Protein Sci (ISSN: 0961-8368, 1469-896xelectronic), 2000 Dec; 9(12): 2577-2582.
Impact Factor: 3.869
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Esposito L, Sica F, Sorrentino G, Berisio R, Carotenuto L, Giordano A, Raia C, Rossi M, Lamzin VS, Willson KS, Zagari A
Protein Crystal Growth In The Advance Protein Crystallisation Facility On The Lms Mission: A Comparison Of Sulfolobus Solfataricus Alchool Dehydrogenase Crystals Grown On The Ground And In Microgravity (253 views)
Acta Crystallogr D Biol Crystallogr, 1998; 54: 386-390.
Impact Factor: 0
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Esposito L, Sica F, Sorrentino G, Berisio R, Carotenuto L, Giordano A, Raia CA, Rossi M, Lamzin VS, Wilson KS, Zagari A
Protein crystal growth in the advanced protein crystallization facility on the LMS mission: A comparison of Sulfolobus solfataricus alcohol dehydrogenase crystals grown on the ground and in microgravity (433 views)
Acta Crystallogr D Biol Crystallogr (ISSN: 0907-4449, 0907-4449linking), 1998; 54(3): 386-390.
Impact Factor: 2.244
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PEARL L, DEMASI D, HEMMINGS A, SICA F, MAZZARELLA L, RAIA C, DAURIA S, ROSSI M
CRYSTALLIZATION AND PRELIMINARY-X-RAY ANALYSIS OF AN NAD+-DEPENDENT ALCOHOL-DEHYDROGENASE FROM THE EXTREME THERMOPHILIC ARCHAEBACTERIUM SULFOLOBUS-SOLFATARICUS (444 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 1993 Feb 5; 229(3): 782-784.
Impact Factor: 5.673
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* Ultra-rapid glutathionylation of chymotrypsinogen in its molten globule-like conformation: A comparison to archaeal proteins (62 views)
Sci Rep (ISSN: 2045-2322linking, 2045-2322electronic), 2020 Jun 2; 10(1): 8943-8943.
Impact Factor: 3.998
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Ruggiero A, Smaldone G, Esposito L, Balasco N, Vitagliano L
* Loop size optimization induces a strong thermal stabilization of the thioredoxin fold (193 views)
Febs J (ISSN: 1742-464xlinking), 2019 May; 286(9): 1752-1764.
Impact Factor: 3.129
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Barresi V, Spampinato G, Musso N, Trovato Salinaro A, Rizzarelli E, Condorelli DF
* ATOX1 gene silencing increases susceptibility to anticancer therapy based on copper ionophores or chelating drugs (719 views)
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Impact Factor: 3.348
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Calce E, Vitale RM, Scaloni A, Amodeo P, De Luca S
* Air oxidation method employed for the disulfide bond formation of natural and synthetic peptides (597 views)
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Impact Factor: 3.196
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Ringhieri P, Diaferia C, Galdiero S, Palumbo R, Morelli G, Accardo A
* Liposomal doxorubicin doubly functionalized with CCK8 and R8 peptide sequences for selective intracellular drug delivery (451 views)
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Impact Factor: 1.951
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Benetti F, Biarnés X, Attanasio F, Giachin G, Rizzarelli E, Legname G
* Structural determinants in prion protein folding and stability (554 views)
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Impact Factor: 4.333
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Pedone E, Fiorentino G, Pirone L, Contursi P, Bartolucci S, Limauro D
* Functional and structural characterization of protein disulfide oxidoreductase from Thermus thermophilus HB27 (343 views)
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Impact Factor: 2.306
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Limauro D, De Simone G, Pirone L, Bartolucci S, D'Ambrosio K, Pedone E
* Sulfolobus solfataricus thiol redox puzzle: characterization of an atypical protein disulfide oxidoreductase (429 views)
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Impact Factor: 2.306
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Messori L, Scaletti F, Massai L, Cinellu MA, Russo Krauss I, Di Martino G, Vergara A, Paduano L, Merlino A
* Interactions of gold-based drugs with proteins: crystal structure of the adduct formed between ribonuclease A and a cytotoxic gold(III) compound (339 views)
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Impact Factor: 3.585
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Petruk AA, Varriale S, Coscia MR, Mazzarella L, Merlino A, Oreste U
* The Structure Of The Cd3 Zeta Zeta Transmembrane Dimer In Popc And Raft-Like Lipid Bilayer: A Molecular Dynamics Study (441 views)
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Impact Factor: 3.498
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Cammisa M, Correra A, Andreotti G, Cubellis MV
* Fabry_CEP: a tool to identify Fabry mutations responsive to pharmacological chaperones (415 views)
Orphanet Journal Of Rare Diseases (ISSN: 1750-1172), 2013 Jul 24; 8: 111-111.
Impact Factor: 3.958
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Avitabile C, Capparelli R, Rigano MM, Fulgione A, Barone A, Pedone C, Romanelli A
* Antimicrobial peptides from plants: Stabilization of the γ core of a tomato defensin by intramolecular disulfide bond (755 views)
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Impact Factor: 1.862
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Martucci NM, Lamberti A, Vitagliano L, Cantiello P, Ruggiero I, Arcari P, Masullo M
* The magic spot ppGpp influences in vitro the molecular and functional properties of the elongation factor 1α from the archaeon Sulfolobus solfataricus (349 views)
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Impact Factor: 2.203
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Esposito L, Ruggiero A, Masullo M, Ruocco MR, Lamberti A, Arcari P, Zagari A, Vitagliano L
* Crystallographic and spectroscopic characterizations of Sulfolobus solfataricus TrxA1 provide insights into the determinants of thioredoxin fold stability (300 views)
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Impact Factor: 3.361
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Palmieri G, Bergamo P, Luini A, Ruvo M, Gogliettino M, Langella E, Saviano M, Hegde RN, Sandomenico A, Rossi M
* Acylpeptide hydrolase inhibition as targeted strategy to induce proteasomal down-regulation (490 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2011 Oct 10; 6(10): e25888-e25888.
Impact Factor: 4.092
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Pedone E, Limauro D, D'Ambrosio K, De Simone G, Bartolucci S
* Multiple catalytically active thioredoxin folds: a winning strategy for many functions (710 views)
Cell Mol Life Sci Cellular And Molecular Life Sciences (ISSN: 1420-682x), 2010 Nov; 67(22): 3797-3814.
Impact Factor: 7.047
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De Simone G, Supuran CT
* Carbonic anhydrase IX: Biochemical and crystallographic characterization of a novel antitumor target (398 views)
Bba-Gen Subjects (ISSN: 1570-9639, 0006-3002, 0925-4439), 2010 Feb; 1804(2): 404-409.
Impact Factor: 2.773
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Pedone E, Limauro D, Bartolucci S
* The Machinery for Oxidative Protein Folding in Thermophiles (vol 10, pg 157, 2008) (315 views)
Antioxid Redox Signal (ISSN: 1523-0864, 1557-7716, 1523-0864linking), 2010 Jan; 12(1): 157-169.
Impact Factor: 8.209
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Palmieri G, Langella E, Gogliettino M, Saviano M, Pocsfalvi G, Rossi M
* A novel class of protease targets of phosphatidylethanolamine-binding proteins (PEBP): A study of the acylpeptide hydrolase and the PEBP inhibitor from the archaeon Sulfolobus solfataricus (376 views)
Mol Biosyst (ISSN: 1742-206x), 2010; 6(12): 2498-2507.
Impact Factor: 3.825
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Scir A, Pedone E, Ausili A, Saviano M, Baldassarre M, Bertoli E, Bartolucci S, Tanfani F
* High hydrostatic pressure-induced conformational changes in protein disulfide oxidoreductase from the hyperthermophilic archaeon Pyrococcus furiosus. A Fourier-transform infrared spectroscopic study (347 views)
Molecular Biosystems (ISSN: 1742-206x), 2010; 6(10): 2015-2022.
Impact Factor: 3.825
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Ruggiero A, Masullo M, Marasco D, Ruocco MR, Grimaldi P, Arcari P, Zagari A, Vitagliano L
* The dimeric structure of Sulfolobus solfataricus thioredoxin A2 and the basis of its thermostability (316 views)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2009 Dec; 77(4): 1004-1008.
Impact Factor: 3.085
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Alterio V, Hilvo M, Di Fiore A, Supuran CT, Pan P, Parkkila S, Scaloni A, Pastorek J, Pastorekova S, Pedone C, Scozzafava A, Monti SM, De Simone G
* Crystal structure of the catalytic domain of the tumor-associated human carbonic anhydrase IX (561 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2009 Sep 22; 106(38): 16233-16238.
Impact Factor: 9.432
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D'Ambrosio K, Limauro D, Pedone E, Galdi I, Pedone C, Bartolucci S, De Simone G
* Insights into the catalytic mechanism of the Bcp family: functional and structural analysis of Bcp1 from Sulfolobus solfataricus (469 views)
Proteins (ISSN: 1097-0134, 0887-3585, 1097-0134electronic), 2009 Sep; 76(4): 995-1006.
Impact Factor: 3.085
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Pennacchio A, Esposito L, Zagari A, Rossi M, Raia CA
* Role of Tryptophan 95 in substrate specificity and structural stability of Sulfolobus solfataricus alcohol dehydrogenase (298 views)
Extremophiles (ISSN: 1431-0651, 1433-4909, 1433-4909electronic), 2009 Sep; 13(5): 751-761.
Impact Factor: 2
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Ruggiero I, Cantiello P, Lamberti A, Sorrentino A, Martucci NM, Ruggiero A, Arcone R, Vitagliano L, Arcari P, Masullo M
* Biochemical Characterisation Of The D60a Mutant Of The Elongation Factor 1 Alpha From The Archaeon Sulfolobus Solfataricus (307 views)
Biochimie (ISSN: 0300-9084, 1638-6183, 1638-6183electronic), 2009 Jul; 91(7): 835-842.
Impact Factor: 3.897
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Ruggiero A, Lanzotti MA, Ruocco MR, Grimaldi P, Marasco D, Arcari P, Masullo M, Zagari A, Vitagliano L
* Crystallization and preliminary X-ray crystallographic analysis of two dimeric hyperthermostable thioredoxins isolated from Sulfolobus solfataricus (337 views)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1744-3091, 1744-4309), 2009 Jun; 65: 604-607.
Impact Factor: 0.551
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Di Fiore A, Fiorentino G, Vitale RM, Ronca R, Amodeo P, Pedone C, Bartolucci S, De Simone G
* Structural analysis of BldR from Sulfolobus solfataricus provides insights into the molecular basis of transcriptional activation in Archaea by MarR family proteins (470 views)
J Mol Biol (ISSN: 1089-8638, 0022-2836, 1089-8638electronic), 2009 May 8; 388(3): 559-569.
Impact Factor: 3.871
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Accardo A, Tesauro D, Morisco A, Mangiapia G, Vaccaro M, Gianolio E, Heenan RK, Paduano L, Morelli G
* Micelles obtained by aggregation of gemini surfactants containing the CCK8 peptide and a gadolinium complex (398 views)
J Biol Inorg Chem (ISSN: 0949-8257, 1432-1327electronic, 0949-8257linking), 2009 May; 14(4): 587-599.
Impact Factor: 3.415
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Ruggiero A, Masullo M, Ruocco MR, Grimaldi P, Lanzotti MA, Arcari P, Zagari A, Vitagliano L
* Structure and stability of a thioredoxin reductase from Sulfolobus solfataricus: A thermostable protein with two functions (347 views)
Bba-Gen Subjects (ISSN: 1570-9639, 0006-3002, 0925-4439), 2009 Mar; 1794(3): 554-562.
Impact Factor: 2.48
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Palmieri G, Catara G, Saviano M, Langella E, Gogliettino M, Rossi M
* First archaeal PEPB-serine protease inhibitor from sulfolobus solfataricus with noncanonical amino acid sequence in the reactive-site loop (396 views)
J Proteome Res (ISSN: 1535-3893), 2009 Jan; 8(1): 327-334.
Impact Factor: 5.132
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Limauro D, Saviano M, Galdi I, Rossi M, Bartolucci S, Pedone E
* Sulfolobus solfataricus protein disulphide oxidoreductase: insight into the roles of its redox sites (234 views)
Protein Engineering Design & Selection (ISSN: 1741-0126), 2009 Jan; 22(1): 19-26.
Impact Factor: 2.596
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Hilvo M, Baranauskiene L, Salzano AM, Scaloni A, Matulis D, Innocenti A, Scozzafava A, Monti SM, Di Fiore A, De Simone G, Lindfors M, Janis J, Valjakka J, Pastorekova S, Pastorek J, Kulomaa MS, Nordlund HR, Supuran CT, Parkkila S
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Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2008 Oct 10; 283(41): 27799-27809.
Impact Factor: 5.52
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Dalla Serra M, Cirioni O, Vitale RM, Renzone G, Coraiola M, Giacometti A, Potrich C, Baroni E, Guella G, Sanseverino M, De Luca S, Scalise G, Amodeo P, Scaloni A
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Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2008 Jul 29; 47(30): 7888-7899.
Impact Factor: 3.379
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Grimaldi P, Ruocco MR, Lanzotti MA, Ruggiero A, Ruggiero I, Arcari P, Vitagliano L, Masullo M
* Characterisation of the components of the thioredoxin system in the archaeon Sulfolobus solfataricus (356 views)
Extremophiles (ISSN: 1431-0651, 1433-4909, 1433-4909electronic), 2008 Jul; 12(4): 553-562.
Impact Factor: 1.782
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Limauro D, Pedone E, Galdi I, Bartolucci S
* Peroxiredoxins as cellular guardians in Sulfolobus solfataricus - characterization of Bcp1, Bcp3 and Bcp4 (366 views)
Febs Journal (ISSN: 1742-464x), 2008 May; 275(9): 2067-2077.
Impact Factor: 3.139
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Granata V, Graziano G, Ruggiero A, Raimo G, Masullo M, Arcari P, Vitagliano L, Zagari A
* Stability Against Temperature Of Sulfolobus Solfataricus Elongation Factor 1 Alpha, A Multi-Domain Protein (372 views)
Bba-Gen Subjects (ISSN: 1570-9639, 0006-3002, 0925-4439), 2008 Apr; 1784(4): 573-581.
Impact Factor: 2.233
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Pedone E, Limauro D, Bartolucci S
* The machinery for oxidative protein folding in thermophiles (337 views)
Antioxid Redox Signal (ISSN: 1523-0864, 1557-7716, 1523-0864linking), 2008 Jan; 10(1): 157-169.
Impact Factor: 6.19
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Prato S, Vitale RM, Contursi P, Lipps G, Saviano M, Rossi M, Bartolucci S
* Molecular modeling and functional characterization of the monomeric primase-polymerase domain from the Sulfolobus solfataricus plasmid pIT3 (398 views)
Febs J (ISSN: 1742-464x), 2008; 275(17): 4389-4402.
Impact Factor: 3.139
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Pedone E, Limauro D, D'Alterio R, Rossi M, Bartolucci S
* Characterization of a multifunctional protein disulfide oxidoreductase from Sulfolobus solfataricus (328 views)
Febs Journal (ISSN: 1742-464x), 2006 Dec; 273(23): 5407-5420.
Impact Factor: 3.033
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De Simone A, Berisio R, Zagari A, Vitagliano L
* Limited Tendency Of Alpha-Helical Residues To Form Disulfide Bridges: A Structural Explanation (485 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2006 Dec; 12(12): 740-747.
Impact Factor: 1.801
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Calvanese L, Saporito A, Marasco D, D'Auria G, Minchiotti G, Pedone C, Paolillo L, Falcigno L, Ruvo M
* Solution structure of mouse Cripto CFC domain and its inactive variant Trp107Ala (429 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2006 Nov 30; 49(24): 7054-7062.
Impact Factor: 5.115
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D'Ambrosio K, Pedone E, Langella E, De Simone G, Rossi M, Pedone C, Bartolucci S
* A novel member of the protein disulfide oxidoreductase family from Aeropyrum pernix K1: Structure, function and electrostatics (475 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2006 Sep 29; 362(4): 743-752.
Impact Factor: 4.89
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De Simone G, Vitale RM, Di Fiore A, Pedone C, Scozzafava A, Montero JL, Winum JY, Supuran CT
* Carbonic anhydrase inhibitors: Hypoxia-activatable sulfonamides incorporating disulfide bonds that target the tumor-associated isoform IX (474 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2006 Sep 7; 49(18): 5544-5551.
Impact Factor: 5.115
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Pedone E, D'Ambrosio K, De Simone G, Rossi M, Pedone C, Bartolucci S
* Insights on a new PDI-like family: Structural and functional analysis of a protein disulfide oxidoreductase from the bacterium Aquifex aeolicus (391 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2006 Feb 10; 356(1): 155-164.
Impact Factor: 4.89
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Limauro D, Pedone E, Pirone L, Bartolucci S
* Identification and characterization of 1-Cys peroxiredoxin from Sulfolobus solfataricus and its involvement in the response to oxidative stress (362 views)
Febs Journal (ISSN: 1742-464x), 2006 Feb; 273(4): 721-731.
Impact Factor: 3.033
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Granata V, Graziano G, Ruggiero A, Raimo G, Masullo M, Arcari P, Vitagliano L, Zagari A
* Chemical Denaturation Of The Elongation Factor 1 Alpha Isolated From The Hyperthermophilic Archaeon Sulfolobus Solfataricus (343 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2006 Jan 24; 45(3): 719-726.
Impact Factor: 3.633
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Ruggiero A, Masullo M, Arcari P, Raimo G, Vitagliano L, Zagari A
* Crystallization And Preliminary X-Ray Crystallographic Analysis Of The Sulfolobus Solfataricus Nucleotide-Exchange Factor 1 Beta (340 views)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1744-3091, 1744-4309), 2005 Nov; 61(11): 1000-1002.
Impact Factor: 0.568
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Pedone E, Saviano M, Bartolucci S, Rossi M, Ausili A, Scire A, Bertoli E, Tanfani F
* Temperature-, SDS-, and pH-induced conformational changes in protein disulfide oxidoreductase from the archaeon Pyrococcus furiosus: A dynamic simulation and fourier transform infrared spectroscopic study (318 views)
J Proteome Res (ISSN: 1535-3893), 2005 Nov; 4(6): 1972-1980.
Impact Factor: 6.901
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Ruggiero A, Ruocco MR, Grimaldi P, Arcari P, Masullo M, Zagari A, Vitagliano L
* Crystallization and preliminary X-ray crystallographic analysis of Sulfolobus solfataricus thioredoxin reductase (319 views)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1744-3091, 1744-4309), 2005 Oct; 61: 906-909.
Impact Factor: 0.568
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Merlino A, Mazzarella L, Carannante A, Di Fiore A, Di Donato A, Notomista E, Sica F
* The importance of dynamic effects on the enzyme activity: X-ray structure and molecular dynamics of onconase mutants (441 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2005 May 6; 280(18): 17953-17960.
Impact Factor: 5.854
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Picone D, Di Fiore A, Ercole C, Franzese M, Sica F, Tomaselli S, Mazzarella L
* The role of the hinge loop in domain swapping - The special case of bovine seminal ribonuclease (365 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2005 Apr 8; 280(14): 13771-13778.
Impact Factor: 5.854
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Esposito L, De Simone A, Zagari A, Vitagliano L
* Correlation Between Omega And Psi Dihedral Angles In Protein Structures (562 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2005 Apr 1; 347(3): 483-487.
Impact Factor: 5.229
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D'Ambrosio K, De Simone G, Pedone E, Rossi M, Bartolucci S, Pedone C
* Crystallization and preliminary X-ray diffraction studies of a protein disulfide oxidoreductase from Aeropyrum pernix K1 (346 views)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1744-3091, 1744-4309), 2005 Mar 1; 61(3): 335-336.
Impact Factor: 0.568
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Merlino A, Graziano G, Mazzarella L
* Structural And Dynamic Effects Of Alpha-Helix Deletion In Sso7d: Implications For Protein Thermal Stability (375 views)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2004 Dec 1; 57(4): 692-701.
Impact Factor: 4.429
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D'Ambrosio K, De Simone G, Pedone E, Rossi M, Bartolucci S, Pedone C
* Crystallization and preliminary X-ray diffraction studies of a protein disulfide oxidoreductase from Aquifex aeolicus (354 views)
Acta Crystallogr D Biol Crystallogr (ISSN: 0907-4449, 0907-4449linking), 2004 Nov; 60(11): 2076-2077.
Impact Factor: 1.693
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Sica F, Di Fiore A, Merlino A, Mazzarella L
* Structure and stability of the non-covalent swapped dimer of bovine seminal ribonuclease - An enzyme tailored to evade ribonuclease protein inhibitor (443 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2004 Sep 27; 279(35): 36753-36760.
Impact Factor: 6.355
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Pedone E, Bartolucci S, Fiorentino G
* Sensing and adapting to environmental stress: The Archaeal tactic (327 views)
Frontiers In Bioscience (ISSN: 1093-9946, 1093-4715), 2004 Sep 1; 9: 2909-2926.
Impact Factor: 3.226
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Pedone E, Ren B, Ladenstein R, Rossi M, Bartolucci S
* Functional properties of the protein disulfide oxidoreductase from the archaeon Pyrococcus furiosus - A member of a novel protein family related to protein disulfide-isomerase (375 views)
Eur J Biochem (ISSN: 0014-2956, 0014-2956print), 2004 Sep; 271(16): 3437-3448.
Impact Factor: 3.26
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Merlino A, Vitagliano L, Sica F, Zagari A, Mazzarella L
* Population shift vs induced fit: The case of bovine seminal ribonuclease swapping dimer (383 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2004 Apr 15; 73(6): 689-695.
Impact Factor: 2.863
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Vitagliano L, Ruggiero A, Masullo M, Cantiello P, Arcari P, Zagari A
* The Crystal Structure Of Sulfolobus Solfataricus Elongation Factor 1 Alpha In Complex With Magnesium And Gdp (478 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2004; 43(21): 6630-6636.
Impact Factor: 4.008
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Esposito L, Bruno I, Sica F, Raia CA, Giordano A, Rossi M, Mazzarella L, Zagari A
* Crystal structure of a ternary complex of the alcohol dehydrogenase from Sulfolobus solfataricus (499 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2003 Dec 16; 42(49): 14397-14407.
Impact Factor: 3.922
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Sica F, Di Fiore A, Zagari A, Mazzarella L
* The unswapped chain of bovine seminal ribonuclease: Crystal structure of the free and liganded monomeric derivative (340 views)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2003 Sep 1; 52(2): 263-271.
Impact Factor: 4.313
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Esposito L, Bruno I, Sica F, Raia CA, Giordano A, Rossi M, Mazzarella L, Zagari A
* Structural study of a single-point mutant of Sulfolobus solfataricus alcohol dehydrogenase with enhanced activity (313 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 2003 Mar 27; 539(1-3): 14-18.
Impact Factor: 3.609
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Esposito L, Sica F, Raia CA, Giordano A, Rossi M, Mazzarella L, Zagari A
* Crystal Structure Of The Alcohol Dehydrogenase From The Hyperthermophilic Archaeon Sulfolobus Solfataricus At 1. 85 Angstrom Resolution (435 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2002 Apr 26; 318(2): 463-477.
Impact Factor: 5.359
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Masullo M, Cantiello P, Paola B, Fiengo A, Vitagliano L, Zagari A, Arcari P
* Valine114 Replacements In The Archaeal Elongation Factor 1a Enhanced Its Ability To Interact With Aminoacyl-Trna And Kirromycin (352 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2002; 41(49): 14482-14488.
Impact Factor: 4.064
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Vitagliano L, Masullo M, Sica F, Zagari A, Bocchini V
* The crystal structure of Sulfolobus solfataricus elongation factor 1α in complex with GDP reveals novel features in nucleotide binding and exchange (452 views)
Embo J (ISSN: 0261-4189, 0261-4189linking), 2001 Oct 1; 20(19): 5305-5311.
Impact Factor: 12.459
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Orru S, Vitagliano L, Esposito L, Mazzarella L, Marino G, Ruoppolo M
Effect of deamidation on folding of ribonuclease (385 views)
Protein Sci (ISSN: 0961-8368, 1469-896xelectronic), 2000 Dec; 9(12): 2577-2582.
Impact Factor: 3.869
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Esposito L, Sica F, Sorrentino G, Berisio R, Carotenuto L, Giordano A, Raia C, Rossi M, Lamzin VS, Willson KS, Zagari A
Protein Crystal Growth In The Advance Protein Crystallisation Facility On The Lms Mission: A Comparison Of Sulfolobus Solfataricus Alchool Dehydrogenase Crystals Grown On The Ground And In Microgravity (253 views)
Acta Crystallogr D Biol Crystallogr, 1998; 54: 386-390.
Impact Factor: 0
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Esposito L, Sica F, Sorrentino G, Berisio R, Carotenuto L, Giordano A, Raia CA, Rossi M, Lamzin VS, Wilson KS, Zagari A
Protein crystal growth in the advanced protein crystallization facility on the LMS mission: A comparison of Sulfolobus solfataricus alcohol dehydrogenase crystals grown on the ground and in microgravity (433 views)
Acta Crystallogr D Biol Crystallogr (ISSN: 0907-4449, 0907-4449linking), 1998; 54(3): 386-390.
Impact Factor: 2.244
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PEARL L, DEMASI D, HEMMINGS A, SICA F, MAZZARELLA L, RAIA C, DAURIA S, ROSSI M
CRYSTALLIZATION AND PRELIMINARY-X-RAY ANALYSIS OF AN NAD+-DEPENDENT ALCOHOL-DEHYDROGENASE FROM THE EXTREME THERMOPHILIC ARCHAEBACTERIUM SULFOLOBUS-SOLFATARICUS (444 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 1993 Feb 5; 229(3): 782-784.
Impact Factor: 5.673
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70 Records (69 excluding Abstracts).
Total impact factor: 266.129 (262.171 excluding Abstracts).
Total 5 year impact factor: 261.87 (256.49 excluding Abstracts).
Total impact factor: 266.129 (262.171 excluding Abstracts).
Total 5 year impact factor: 261.87 (256.49 excluding Abstracts).
373 views. Last view on Tuesday 21 March 2023, 12:55:25
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