Fenfluramine-induced serotonin release decreases [11C]AZ10419369 binding to 5-HT1B-receptors in the primate brain (362 views)
Synapse (ISSN: 0887-4476), 2010 Jul; 64(7): 573-577.
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Paper type: Journal Article,
Impact factor: 2.925, 5-year impact factor: 2.638
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-77953860552&partnerID=40&md5=1d4e7c85ca4220633c54221c24c132ab
Keywords: 5-Ht1b, Pet, Primate Brain, Radioligand, Serotonin Release, Az 10419369, Carbon 11, Fenfluramine, Serotonin 1b Receptor, Unclassified Drug, Animal Experiment, Article, Brain Region, Dose Response, Drug Sensitivity, Experimental Monkey, Ligand Binding, Nonhuman, Positron Emission Tomography, Priority Journal, Radioactivity, Receptor Binding, Benzopyrans, Carbon Radioisotopes, Dose-Response Relationship, Female, Macaca Fascicularis, Morpholines, Piperazines, Positron-Emission Tomography, Radiopharmaceuticals, Serotonin Agents, Time Factors,
Affiliations:
*** IBB - CNR ***
Karolinska Institutet, Department of Clinical Neuroscience, Psychiatry Section, SE-17176 Stockholm, Sweden
AstraZeneca, R and D, Wilmington, DE, United States
Department of Psychiatry, College of Medicine, National Taiwan University, Taipei, Taiwan
References:
Aznavour, N., Rbah, L., Riad, M., Reilhac, A., Costes, N., Descarries, L., Zimmer, L., A PET imaging study of 5-HT(1A) receptors in cat brain after acute and chronic fluoxetine treatment (2006) Neuroimage, 33, pp. 834-84
Derry, C., Benjamin, C., Bladin, P., Le Bars, D., Tochon-Danguy, H., Berkovic, S.F., Zimmer, L., Reutens, D., Increased serotonin receptor availability in human sleep: Evidence from an [18F]MPPF PET study in narcolepsy (2006) Neuroimage, 30, pp. 341-348
Engel, G., Gothert, M., Hoyer, D., Identity of inhibitory presynaptic 5-hydroxytryptamine (5-HT) autoreceptors in the rat brain cortex with 5-HT(1B) binding sites (1986) Naunyn-Schmiedeberg's Archives of Pharmacology, 332 (1), pp. 1-7
Gothert, M., Schlicker, E., Fink, K., Classen, K., Effects of RU 24969 on serotonin release in rat brain cortex: Further support for the identity of serotonin autoreceptors with 5-HT(1B) sites (1987) Archives Internationales de Pharmacodynamie et de Therapie, 288 (1), pp. 31-42
Hume, S., Hirani, E., Opacka-Juffry, J., Myers, R., Townsend, C., Pike, V., Grasby, P., Effect of 5-HT on binding of [(11)C] WAY 100635 to 5-HT(IA) receptors in rat brain, assessed using in vivo microdialysis and PET after fenfluramine (2001) Synapse, 41, pp. 150-159
Janoshazi, A., Deraet, M., Callebert, J., Setola, V., Guenther, S., Saubamea, B., Manivet, P., Maroteaux, L., Modified receptor internalization upon coexpression of 5-HT1B receptor and 5-HT2B receptors (2007) Mol Pharmacol, 71, pp. 1463-1474
Koepp, M.J., Gunn, R.N., Lawrence, A.D., Cunningham, V.J., Dagher, A., Jones, T., Brooks, D.J., Grasby, P.M., Evidence for striatal dopamine release during a video game (1998) Nature, 393, pp. 266-268
Laruelle, M., Imaging synaptic neurotransmission with in vivo binding competition techniques: A critical review (2000) Journal of Cerebral Blood Flow and Metabolism, 20 (3), pp. 423-451
Maeda, J., Suhara, T., Ogawa, M., Okauchi, T., Kawabe, K., Zhang, M.R., Semba, J., Suzuki, K., In vivo binding properties of [carbonyl-11C]WAY-100635: Effect of endogenous serotonin (2001) Synapse, 40, pp. 122-129
Maura, G., Roccatagliata, E., Raiteri, M., Serotonin autoreceptor in rat hippocampus: Pharmacological characterization as a subtype of the 5-HT1 receptor (1986) Naunyn Schmiedebergs Arch Pharmacol, 334, pp. 323-326
Mennini, T., Bizzi, A., Caccia, S., Codegoni, A., Fracasso, C., Frittoli, E., Guiso, G., Garattini, S., Comparative studies on the anorectic activity of d-fenfluramine in mice, rats, and guinea pigs (1991) Naunyn Schmiedebergs Arch Pharmacol, 343, pp. 483-490
Mukaida, K., Shichino, T., Koyanagi, S., Himukashi, S., Fukuda, K., Activity of the serotonergic system during isoflurane anesthesia (2007) Anesth Analg, 104, pp. 836-839
Pierson, M.E., Andersson, J., Nyberg, S., McCarthy, D.J., Finnema, S.J., Varnas, K., Takano, A., Halldin, C., [11C]AZ10419369: A selective 5-HT1B receptor radioligand suitable for positron emission tomography (PET) Characterization in the primate brain (2008) Neuroimage, 41, pp. 1075-1085
Praschak-Rieder, N., Hussey, D., Wilson, A.A., Carella, A., Lee, M., Dunn, E., Willeit, M., Meyer, J.H., Tryptophan depletion and serotonin loss in selective serotonin reuptake inhibitor-treated depression: An [(18)F] MPPF positron emission tomography study (2004) Biol Psychiatry, 56, pp. 587-591
Sayer, T.J., Hannon, S.D., Redfern, P.H., Martin, K.F., Diurnal variation in 5-HT1B autoreceptor function in the anterior hypothalamus in vivo Effect of chronic antidepressant drug treatment (1999) Br J Pharmacol, 126, pp. 1777-1784
Sibon, I., Benkelfat, C., Gravel, P., Aznavour, N., Costes, N., Mzengeza, S., Booij, L., Descarries, L., Decreased [18F]MPPF binding potential in the dorsal raphe nucleus after a single oral dose of fluoxetine: A positron-emission tomography study in healthy volunteers (2008) Biol Psychiatry, 63, pp. 1135-1140
Tomasi, G., Nabulsi, N., Weinzimmer, D., Sandiego, C., Gallezot, J.D., Wang, E., McLean, S., Carson, R.E., In vivo Scatchard analysis of bolus/infusion 5-HT1B studies with [11C]P943: Comparison between SRTM and equilibrium methods (2008) NeuroImage, 41, pp. T16
De Udo Haes, J.I., Bosker, F.J., Van Waarde, A., Pruim, J., Willemsen, A.T., Vaalburg, W., Den Boer, J.A., 5-HT(1A) receptor imaging in the human brain: Effect of tryptophan depletion and infusion on [(18)F]MPPF binding (2002) Synapse, 46, pp. 108-115
Varnäs, K., Hall, H., Bonaventure, P., Sedvall, G., Autoradiographic mapping of 5-HT(1B) and 5-HT(1D) receptors in the post mortem human brain using [H]GR 125743 (2001) Brain Res, 915, pp. 47-57
Varrone, A., Sjoholm, N., Eriksson, L., Gulyas, B., Halldin, C., Farde, L., Advancement in PET quantification using 3D-OP-OSEM point spread function reconstruction with the HRRT (2009) Eur J Nucl Med Mol Imaging, 36, pp. 1639-1650
Volkow, N.D., Wang, G.-J., Fowler, J.S., Logan, J., Schlyer, D., Hitzemann, R., Lieberman, J., Wolf, A.P., Imaging endogenous dopamine competition with [11C]raclopride in the human brain (1994) Synapse, 16 (4), pp. 255-262
Zimmer, L., Mauger, G., Le Bars, D., Bonmarchand, G., Luxen, A., Pujol, J.F., Effect of endogenous serotonin on the binding of the 5-hT1A PET ligand 18F-MPPF in the rat hippocampus Kinetic beta measurements combined with microdialysis (2002) J Neurochem, 80, pp. 278-286
Zimmer, L., Rbah, L., Giacomelli, F., Le Bars, D., Renaud, B., A reduced extracellular serotonin level increases the 5-HT1A PET ligand 18F-MPPF binding in the rat hippocampus (2003) Journal of Nuclear Medicine, 44 (9), pp. 1495-1501
Koepp, M. J., Gunn, R. N., Lawrence, A. D., Cunningham, V. J., Dagher, A., Jones, T., Brooks, D. J., Grasby, P. M., Evidence for striatal dopamine release during a video game (1998) Nature, 393, pp. 266-268
Pierson, M. E., Andersson, J., Nyberg, S., McCarthy, D. J., Finnema, S. J., Varnas, K., Takano, A., Halldin, C., [11C] AZ10419369: A selective 5-HT1B receptor radioligand suitable for positron emission tomography (PET) Characterization in the primate brain (2008) Neuroimage, 41, pp. 1075-1085
Sayer, T. J., Hannon, S. D., Redfern, P. H., Martin, K. F., Diurnal variation in 5-HT1B autoreceptor function in the anterior hypothalamus in vivo Effect of chronic antidepressant drug treatment (1999) Br J Pharmacol, 126, pp. 1777-1784
De Udo Haes, J. I., Bosker, F. J., Van Waarde, A., Pruim, J., Willemsen, A. T., Vaalburg, W., Den Boer, J. A., 5-HT (1A) receptor imaging in the human brain: Effect of tryptophan depletion and infusion on [(18) F] MPPF binding (2002) Synapse, 46, pp. 108-115
Varn s, K., Hall, H., Bonaventure, P., Sedvall, G., Autoradiographic mapping of 5-HT (1B) and 5-HT (1D) receptors in the post mortem human brain using [H] GR 125743 (2001) Brain Res, 915, pp. 47-57
Volkow, N. D., Wang, G. -J., Fowler, J. S., Logan, J., Schlyer, D., Hitzemann, R., Lieberman, J., Wolf, A. P., Imaging endogenous dopamine competition with [11C] raclopride in the human brain (1994) Synapse, 16 (4), pp. 255-262
Synapse (ISSN: 0887-4476), 2010 Jul; 64(7): 573-577.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 2.925, 5-year impact factor: 2.638
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-77953860552&partnerID=40&md5=1d4e7c85ca4220633c54221c24c132ab
Keywords: 5-Ht1b, Pet, Primate Brain, Radioligand, Serotonin Release, Az 10419369, Carbon 11, Fenfluramine, Serotonin 1b Receptor, Unclassified Drug, Animal Experiment, Article, Brain Region, Dose Response, Drug Sensitivity, Experimental Monkey, Ligand Binding, Nonhuman, Positron Emission Tomography, Priority Journal, Radioactivity, Receptor Binding, Benzopyrans, Carbon Radioisotopes, Dose-Response Relationship, Female, Macaca Fascicularis, Morpholines, Piperazines, Positron-Emission Tomography, Radiopharmaceuticals, Serotonin Agents, Time Factors,
Affiliations:
*** IBB - CNR ***
Karolinska Institutet, Department of Clinical Neuroscience, Psychiatry Section, SE-17176 Stockholm, Sweden
AstraZeneca, R and D, Wilmington, DE, United States
Department of Psychiatry, College of Medicine, National Taiwan University, Taipei, Taiwan
References:
Aznavour, N., Rbah, L., Riad, M., Reilhac, A., Costes, N., Descarries, L., Zimmer, L., A PET imaging study of 5-HT(1A) receptors in cat brain after acute and chronic fluoxetine treatment (2006) Neuroimage, 33, pp. 834-84
Derry, C., Benjamin, C., Bladin, P., Le Bars, D., Tochon-Danguy, H., Berkovic, S.F., Zimmer, L., Reutens, D., Increased serotonin receptor availability in human sleep: Evidence from an [18F]MPPF PET study in narcolepsy (2006) Neuroimage, 30, pp. 341-348
Engel, G., Gothert, M., Hoyer, D., Identity of inhibitory presynaptic 5-hydroxytryptamine (5-HT) autoreceptors in the rat brain cortex with 5-HT(1B) binding sites (1986) Naunyn-Schmiedeberg's Archives of Pharmacology, 332 (1), pp. 1-7
Gothert, M., Schlicker, E., Fink, K., Classen, K., Effects of RU 24969 on serotonin release in rat brain cortex: Further support for the identity of serotonin autoreceptors with 5-HT(1B) sites (1987) Archives Internationales de Pharmacodynamie et de Therapie, 288 (1), pp. 31-42
Hume, S., Hirani, E., Opacka-Juffry, J., Myers, R., Townsend, C., Pike, V., Grasby, P., Effect of 5-HT on binding of [(11)C] WAY 100635 to 5-HT(IA) receptors in rat brain, assessed using in vivo microdialysis and PET after fenfluramine (2001) Synapse, 41, pp. 150-159
Janoshazi, A., Deraet, M., Callebert, J., Setola, V., Guenther, S., Saubamea, B., Manivet, P., Maroteaux, L., Modified receptor internalization upon coexpression of 5-HT1B receptor and 5-HT2B receptors (2007) Mol Pharmacol, 71, pp. 1463-1474
Koepp, M.J., Gunn, R.N., Lawrence, A.D., Cunningham, V.J., Dagher, A., Jones, T., Brooks, D.J., Grasby, P.M., Evidence for striatal dopamine release during a video game (1998) Nature, 393, pp. 266-268
Laruelle, M., Imaging synaptic neurotransmission with in vivo binding competition techniques: A critical review (2000) Journal of Cerebral Blood Flow and Metabolism, 20 (3), pp. 423-451
Maeda, J., Suhara, T., Ogawa, M., Okauchi, T., Kawabe, K., Zhang, M.R., Semba, J., Suzuki, K., In vivo binding properties of [carbonyl-11C]WAY-100635: Effect of endogenous serotonin (2001) Synapse, 40, pp. 122-129
Maura, G., Roccatagliata, E., Raiteri, M., Serotonin autoreceptor in rat hippocampus: Pharmacological characterization as a subtype of the 5-HT1 receptor (1986) Naunyn Schmiedebergs Arch Pharmacol, 334, pp. 323-326
Mennini, T., Bizzi, A., Caccia, S., Codegoni, A., Fracasso, C., Frittoli, E., Guiso, G., Garattini, S., Comparative studies on the anorectic activity of d-fenfluramine in mice, rats, and guinea pigs (1991) Naunyn Schmiedebergs Arch Pharmacol, 343, pp. 483-490
Mukaida, K., Shichino, T., Koyanagi, S., Himukashi, S., Fukuda, K., Activity of the serotonergic system during isoflurane anesthesia (2007) Anesth Analg, 104, pp. 836-839
Pierson, M.E., Andersson, J., Nyberg, S., McCarthy, D.J., Finnema, S.J., Varnas, K., Takano, A., Halldin, C., [11C]AZ10419369: A selective 5-HT1B receptor radioligand suitable for positron emission tomography (PET) Characterization in the primate brain (2008) Neuroimage, 41, pp. 1075-1085
Praschak-Rieder, N., Hussey, D., Wilson, A.A., Carella, A., Lee, M., Dunn, E., Willeit, M., Meyer, J.H., Tryptophan depletion and serotonin loss in selective serotonin reuptake inhibitor-treated depression: An [(18)F] MPPF positron emission tomography study (2004) Biol Psychiatry, 56, pp. 587-591
Sayer, T.J., Hannon, S.D., Redfern, P.H., Martin, K.F., Diurnal variation in 5-HT1B autoreceptor function in the anterior hypothalamus in vivo Effect of chronic antidepressant drug treatment (1999) Br J Pharmacol, 126, pp. 1777-1784
Sibon, I., Benkelfat, C., Gravel, P., Aznavour, N., Costes, N., Mzengeza, S., Booij, L., Descarries, L., Decreased [18F]MPPF binding potential in the dorsal raphe nucleus after a single oral dose of fluoxetine: A positron-emission tomography study in healthy volunteers (2008) Biol Psychiatry, 63, pp. 1135-1140
Tomasi, G., Nabulsi, N., Weinzimmer, D., Sandiego, C., Gallezot, J.D., Wang, E., McLean, S., Carson, R.E., In vivo Scatchard analysis of bolus/infusion 5-HT1B studies with [11C]P943: Comparison between SRTM and equilibrium methods (2008) NeuroImage, 41, pp. T16
De Udo Haes, J.I., Bosker, F.J., Van Waarde, A., Pruim, J., Willemsen, A.T., Vaalburg, W., Den Boer, J.A., 5-HT(1A) receptor imaging in the human brain: Effect of tryptophan depletion and infusion on [(18)F]MPPF binding (2002) Synapse, 46, pp. 108-115
Varnäs, K., Hall, H., Bonaventure, P., Sedvall, G., Autoradiographic mapping of 5-HT(1B) and 5-HT(1D) receptors in the post mortem human brain using [H]GR 125743 (2001) Brain Res, 915, pp. 47-57
Varrone, A., Sjoholm, N., Eriksson, L., Gulyas, B., Halldin, C., Farde, L., Advancement in PET quantification using 3D-OP-OSEM point spread function reconstruction with the HRRT (2009) Eur J Nucl Med Mol Imaging, 36, pp. 1639-1650
Volkow, N.D., Wang, G.-J., Fowler, J.S., Logan, J., Schlyer, D., Hitzemann, R., Lieberman, J., Wolf, A.P., Imaging endogenous dopamine competition with [11C]raclopride in the human brain (1994) Synapse, 16 (4), pp. 255-262
Zimmer, L., Mauger, G., Le Bars, D., Bonmarchand, G., Luxen, A., Pujol, J.F., Effect of endogenous serotonin on the binding of the 5-hT1A PET ligand 18F-MPPF in the rat hippocampus Kinetic beta measurements combined with microdialysis (2002) J Neurochem, 80, pp. 278-286
Zimmer, L., Rbah, L., Giacomelli, F., Le Bars, D., Renaud, B., A reduced extracellular serotonin level increases the 5-HT1A PET ligand 18F-MPPF binding in the rat hippocampus (2003) Journal of Nuclear Medicine, 44 (9), pp. 1495-1501
Koepp, M. J., Gunn, R. N., Lawrence, A. D., Cunningham, V. J., Dagher, A., Jones, T., Brooks, D. J., Grasby, P. M., Evidence for striatal dopamine release during a video game (1998) Nature, 393, pp. 266-268
Pierson, M. E., Andersson, J., Nyberg, S., McCarthy, D. J., Finnema, S. J., Varnas, K., Takano, A., Halldin, C., [11C] AZ10419369: A selective 5-HT1B receptor radioligand suitable for positron emission tomography (PET) Characterization in the primate brain (2008) Neuroimage, 41, pp. 1075-1085
Sayer, T. J., Hannon, S. D., Redfern, P. H., Martin, K. F., Diurnal variation in 5-HT1B autoreceptor function in the anterior hypothalamus in vivo Effect of chronic antidepressant drug treatment (1999) Br J Pharmacol, 126, pp. 1777-1784
De Udo Haes, J. I., Bosker, F. J., Van Waarde, A., Pruim, J., Willemsen, A. T., Vaalburg, W., Den Boer, J. A., 5-HT (1A) receptor imaging in the human brain: Effect of tryptophan depletion and infusion on [(18) F] MPPF binding (2002) Synapse, 46, pp. 108-115
Varn s, K., Hall, H., Bonaventure, P., Sedvall, G., Autoradiographic mapping of 5-HT (1B) and 5-HT (1D) receptors in the post mortem human brain using [H] GR 125743 (2001) Brain Res, 915, pp. 47-57
Volkow, N. D., Wang, G. -J., Fowler, J. S., Logan, J., Schlyer, D., Hitzemann, R., Lieberman, J., Wolf, A. P., Imaging endogenous dopamine competition with [11C] raclopride in the human brain (1994) Synapse, 16 (4), pp. 255-262
Fenfluramine-induced serotonin release decreases [11C]AZ10419369 binding to 5-HT1B-receptors in the primate brain
The need for positron emission tomography (PET)-radioligands that are sensitive to changes in endogenous serotonin (5-HT) levels in brain is recognized in experimental and clinical psychiatric research. We recently developed the novel PET radioligand [11C]AZ10419369 that is highly selective for the 5-HT1B receptor. In this PET-study in three cynomolgus monkeys, we examined the sensitivity of [11C]AZ10419369 to altered endogenous 5-HT levels. Fenfluramine-induced 5-HT release decreased radioligand binding in a dose-dependent fashion with a regional average of 27% after 1 mg/kg and 50% after 5 mg/kg. This preliminary study supports that [ 11C]AZ10419369 is sensitive to endogenous 5-HT levels in vivo and may serve as a tool to examine the pathophysiology and treatment of major psychiatric disorders. © 2010 Wiley-Liss, Inc.
The need for positron emission tomography (PET)-radioligands that are sensitive to changes in endogenous serotonin (5-HT) levels in brain is recognized in experimental and clinical psychiatric research. We recently developed the novel PET radioligand [11C]AZ10419369 that is highly selective for the 5-HT1B receptor. In this PET-study in three cynomolgus monkeys, we examined the sensitivity of [11C]AZ10419369 to altered endogenous 5-HT levels. Fenfluramine-induced 5-HT release decreased radioligand binding in a dose-dependent fashion with a regional average of 27% after 1 mg/kg and 50% after 5 mg/kg. This preliminary study supports that [ 11C]AZ10419369 is sensitive to endogenous 5-HT levels in vivo and may serve as a tool to examine the pathophysiology and treatment of major psychiatric disorders. © 2010 Wiley-Liss, Inc.
Fenfluramine-induced serotonin release decreases [11C]AZ10419369 binding to 5-HT1B-receptors in the primate brain
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Fenfluramine-induced serotonin release decreases [11C]AZ10419369 binding to 5-HT1B-receptors in the primate brain
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Takano A, Gulyas B, Varrone A, Karlsson P, Schou M, Airaksinen AJ, Vandenhende F, Tauscher J, Halldin C
* Imaging the norepinephrine transporter with positron emission tomography: Initial human studies with (S, S)-[18F]FMeNER-D2 (306 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2008 Jan; 35(1): 153-157.
Impact Factor: 4.532
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Seneca N, Gulyas B, Varrone A, Schou M, Airaksinen A, Tauscher J, Vandenhende F, Kielbasa W, Farde L, Innis R, Halldin C
* Atomoxetine occupies the norepinephrine transporter in a dose-dependent fashion: A PET study in nonhuman primate brain using (S, S)-[18F] FMeNER-D2 (433 views)
Psychopharmacology (ISSN: 0033-3158), 2006 Sep; 188(1): 119-127.
Impact Factor: 3.625
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Del Gatto A, Zaccaro L, Grieco P, Novellino E, Zannetti A, Del Vecchio S, Iommelli F, Salvatore M, Pedone C, Saviano M
* Novel And Selective Alpha (v) Beta3 Receptor Peptide Antagonist: Design, Synthesis, And Biological Behavior (730 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2006 Jun 1; 49(11): 3416-3420.
Impact Factor: 5.115
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Hirst WD, Abrahamsen B, Blaney FE, Calver AR, Aloj L, Price GW, Medhurst AD
* Differences In The Central Nervous System Distribution And Pharmacology Of The Mouse 5-Hydroxytryptamine-6 Receptor Compared With Rat And Human Receptors Investigated By Radioligand Binding, Site-Directed Mutagenesis, And Molecular Modeling (272 views)
Molecular Pharmacology, 2003; 64: 1295-1308.
Impact Factor: 4.12
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* Quantification of dopamine transporter in human brain using PET with 18F-FE-PE2I (574 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 2012 Jul; 53(7): 1065-1073.
Impact Factor: 5.774
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Takano A, Gulyas B, Varrone A, Karlsson P, Sjoholm N, Larsson S, Jonsson C, Odh R, Sparks R, Al Tawil N, Hoffmann A, Zimmermann T, Thiele A, Halldin C
* Biodistribution and radiation dosimetry of the 18 kDa translocator protein (TSPO) radioligand [ 18F]FEDAA1106: A human whole-body PET study (420 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2011 Nov; 38(11): 2058-2065.
Impact Factor: 4.991
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Esmaeilzadeh M, Farde L, Karlsson P, Varrone A, Halldin C, Waters S, Tedroff J
* Extrastriatal dopamine D 2 receptor binding in Huntington's disease (507 views)
Hum Brain Mapp (ISSN: 1065-9471, 1097-0193electronic, 1065-9471linking), 2011 Oct; 32(10): 1626-1636.
Impact Factor: 5.88
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Ocak M, Helbok A, Rangger C, Peitl PK, Nock BA, Morelli G, Eek A, Sosabowskijk, Breeman WA, Reubi JC, Decristoforo C
* Comparison of biological stability and metabolism of CCK2 receptor targeting peptides, a collaborative project under COST BM0607 (710 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2011 Sep; 38(8): 1426-1435.
Impact Factor: 4.991
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Varnäs K, Nyberg S, Halldin C, Varrone A, Takano A, Karlsson P, Andersson J, McCarthy D, Smith M, Pierson ME, Söderström J, Farde L
* Quantitative analysis of [11C]AZ10419369 binding to 5-HT 1B receptors in human brain (424 views)
J Cereb Blood Flow Metab (ISSN: 0271-678x), 2011 Jan; 31(1): 113-123.
Impact Factor: 5.008
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Ciccarelli M, Sorriento D, Cipolletta E, Santulli G, Fusco A, Zhou R-H, Eckhart AD, Peppel K, Koch WJ, Trimarco B, Iaccarino G
* Impaired neoangiogenesis in β2-adrenoceptor gene-deficient mice: Restoration by intravascular human β2-adrenoceptor gene transfer and role of NFkB and CREB transcription factors (370 views)
Br J Pharmacol British Journal Of Pharmacology (ISSN: 0007-1188), 2011; 162(3): 712-721.
Impact Factor: 4.409
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Nag S, Lehmann L, Kettschau G, Thiele A, Varrone A, Gulyas B, Halldin C
* Synthesis and evaluation of [F-18]fluororasagiline, a novel PET radioligand for MAO-B (289 views)
Journal Of Labelled Compounds & Radiopharmaceuticals (ISSN: 0362-4803), 2011; 54: N/D-N/D.
Impact Factor: 1.429
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Varrone A, Halldin C
Molecular imaging of the dopamine transporter (542 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 2010 Sep 1; 51(9): 1331-1334.
Impact Factor: 7.022
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Varrone A, Sjoholm N, Eriksson L, Gulyas B, Halldin C, Farde L
* Advancement in PET quantification using 3D-OP-OSEM point spread function reconstruction with the HRRT (753 views) (PDF 259 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2009 Oct; 36(10): 1639-1650.
Impact Factor: 4.531
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Varrone A, Steiger C, Schou M, Takano A, Finnema SJ, Guilloteau D, Gulyas B, Halldin C
* In vitro autoradiography and in vivo evaluation in cynomolgus monkey of [18F]FE-PE2I, a new dopamine transporter PET radioligand (718 views)
Synapse (ISSN: 0887-4476), 2009 Oct; 63(10): 871-880.
Impact Factor: 2.557
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Takano A, Gulyas B, Varrone A, Maguire RP, Halldin C
* Saturated norepinephrine transporter occupancy by atomoxetine relevant to clinical doses: A rhesus monkey study with (S, S)-[18F]FMeNER-D (373 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2009 Sep; 36(8): 1308-1314.
Impact Factor: 4.531
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Takano A, Varrone A, Gulyas B, Karlsson P, Tauscher J, Halldin C
* Mapping of the norepinephrine transporter in man using PET with (S, S)-[F-18]FMeNER-D-2 (301 views) (PDF 204 views)
Neuroimage (ISSN: 1053-8119, 1053-8119linking), 2008 Sep 15; 41: 474-482.
Impact Factor: 5.694
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Supuran CT, Di Fiore A, De Simone G
* Carbonic anhydrase inhibitors as emerging drugs for the treatment of obesity (572 views)
Expert Opin Emerg Drugsexpert Opinion On Emerging Drugs (ISSN: 1472-8214), 2008 Jun; 13(2): 383-392.
Impact Factor: 3.08
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De Simone G, Di Fiore A, Supuran CT
* Are carbonic anhydrase inhibitors suitable for obtaining antiobesity drugs? (478 views)
Curr Pharm Des Current Pharmaceutical Design (ISSN: 1381-6128, 1873-4286), 2008 Mar; 14(7): 655-660.
Impact Factor: 4.399
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Takano A, Halldin C, Varrone A, Karlsson P, Sjoholm N, Stubbs JB, Schou M, Airaksinen AJ, Tauscher J, Gulyas B
* Biodistribution and radiation dosimetry of the norepinephrine transporter radioligand (S, S)-[18F]FMeNER-D2: A human whole-body PET study (357 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2008 Mar; 35(3): 630-636.
Impact Factor: 4.532
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Jovanovic H, Lundberg J, Karlsson P, Cerin A, Saijo T, Varrone A, Halldin C, Nordstrom AL
* Sex differences in the serotonin 1A receptor and serotonin transporter binding in the human brain measured by PET (495 views)
Neuroimage (ISSN: 1053-8119, 1053-8119linking), 2008 Feb 1; 39(3): 1408-1419.
Impact Factor: 5.694
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Takano A, Gulyas B, Varrone A, Karlsson P, Schou M, Airaksinen AJ, Vandenhende F, Tauscher J, Halldin C
* Imaging the norepinephrine transporter with positron emission tomography: Initial human studies with (S, S)-[18F]FMeNER-D2 (306 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2008 Jan; 35(1): 153-157.
Impact Factor: 4.532
View Export to BibTeX Export to EndNote
Seneca N, Gulyas B, Varrone A, Schou M, Airaksinen A, Tauscher J, Vandenhende F, Kielbasa W, Farde L, Innis R, Halldin C
* Atomoxetine occupies the norepinephrine transporter in a dose-dependent fashion: A PET study in nonhuman primate brain using (S, S)-[18F] FMeNER-D2 (433 views)
Psychopharmacology (ISSN: 0033-3158), 2006 Sep; 188(1): 119-127.
Impact Factor: 3.625
View Export to BibTeX Export to EndNote
Del Gatto A, Zaccaro L, Grieco P, Novellino E, Zannetti A, Del Vecchio S, Iommelli F, Salvatore M, Pedone C, Saviano M
* Novel And Selective Alpha (v) Beta3 Receptor Peptide Antagonist: Design, Synthesis, And Biological Behavior (730 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2006 Jun 1; 49(11): 3416-3420.
Impact Factor: 5.115
View Export to BibTeX Export to EndNote
Hirst WD, Abrahamsen B, Blaney FE, Calver AR, Aloj L, Price GW, Medhurst AD
* Differences In The Central Nervous System Distribution And Pharmacology Of The Mouse 5-Hydroxytryptamine-6 Receptor Compared With Rat And Human Receptors Investigated By Radioligand Binding, Site-Directed Mutagenesis, And Molecular Modeling (272 views)
Molecular Pharmacology, 2003; 64: 1295-1308.
Impact Factor: 4.12
View Export to BibTeX Export to EndNote
20 Records (19 excluding Abstracts).
Total impact factor: 91.914 (90.485 excluding Abstracts).
Total 5 year impact factor: 94.942 (94.048 excluding Abstracts).
Total impact factor: 91.914 (90.485 excluding Abstracts).
Total 5 year impact factor: 94.942 (94.048 excluding Abstracts).
362 views. Last view on Wednesday 07 June 2023, 11:41:24
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