Fenfluramine-induced serotonin release decreases [11C]AZ10419369 binding to 5-HT1B-receptors in the primate brain (716 views)
Synapse (ISSN: 0887-4476), 2010 Jul; 64(7): 573-577.
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Paper type: Journal Article,
Impact factor: 2.925, 5-year impact factor: 2.638
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-77953860552&partnerID=40&md5=1d4e7c85ca4220633c54221c24c132ab
Keywords: 5-Ht1b, Pet, Primate Brain, Radioligand, Serotonin Release, Az 10419369, Carbon 11, Fenfluramine, Serotonin 1b Receptor, Unclassified Drug, Animal Experiment, Article, Brain Region, Dose Response, Drug Sensitivity, Experimental Monkey, Ligand Binding, Nonhuman, Positron Emission Tomography, Priority Journal, Radioactivity, Receptor Binding, Benzopyrans, Carbon Radioisotopes, Dose-Response Relationship, Female, Macaca Fascicularis, Morpholines, Piperazines, Positron-Emission Tomography, Radiopharmaceuticals, Serotonin Agents, Time Factors,
Affiliations:
*** IBB - CNR ***
Karolinska Institutet, Department of Clinical Neuroscience, Psychiatry Section, SE-17176 Stockholm, Sweden
AstraZeneca, R and D, Wilmington, DE, United States
Department of Psychiatry, College of Medicine, National Taiwan University, Taipei, Taiwan
References:
Not available.
Synapse (ISSN: 0887-4476), 2010 Jul; 64(7): 573-577.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 2.925, 5-year impact factor: 2.638
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-77953860552&partnerID=40&md5=1d4e7c85ca4220633c54221c24c132ab
Keywords: 5-Ht1b, Pet, Primate Brain, Radioligand, Serotonin Release, Az 10419369, Carbon 11, Fenfluramine, Serotonin 1b Receptor, Unclassified Drug, Animal Experiment, Article, Brain Region, Dose Response, Drug Sensitivity, Experimental Monkey, Ligand Binding, Nonhuman, Positron Emission Tomography, Priority Journal, Radioactivity, Receptor Binding, Benzopyrans, Carbon Radioisotopes, Dose-Response Relationship, Female, Macaca Fascicularis, Morpholines, Piperazines, Positron-Emission Tomography, Radiopharmaceuticals, Serotonin Agents, Time Factors,
Affiliations:
*** IBB - CNR ***
Karolinska Institutet, Department of Clinical Neuroscience, Psychiatry Section, SE-17176 Stockholm, Sweden
AstraZeneca, R and D, Wilmington, DE, United States
Department of Psychiatry, College of Medicine, National Taiwan University, Taipei, Taiwan
References:
Not available.
Fenfluramine-induced serotonin release decreases [11C]AZ10419369 binding to 5-HT1B-receptors in the primate brain
The need for positron emission tomography (PET)-radioligands that are sensitive to changes in endogenous serotonin (5-HT) levels in brain is recognized in experimental and clinical psychiatric research. We recently developed the novel PET radioligand [11C]AZ10419369 that is highly selective for the 5-HT1B receptor. In this PET-study in three cynomolgus monkeys, we examined the sensitivity of [11C]AZ10419369 to altered endogenous 5-HT levels. Fenfluramine-induced 5-HT release decreased radioligand binding in a dose-dependent fashion with a regional average of 27% after 1 mg/kg and 50% after 5 mg/kg. This preliminary study supports that [ 11C]AZ10419369 is sensitive to endogenous 5-HT levels in vivo and may serve as a tool to examine the pathophysiology and treatment of major psychiatric disorders. © 2010 Wiley-Liss, Inc.
The need for positron emission tomography (PET)-radioligands that are sensitive to changes in endogenous serotonin (5-HT) levels in brain is recognized in experimental and clinical psychiatric research. We recently developed the novel PET radioligand [11C]AZ10419369 that is highly selective for the 5-HT1B receptor. In this PET-study in three cynomolgus monkeys, we examined the sensitivity of [11C]AZ10419369 to altered endogenous 5-HT levels. Fenfluramine-induced 5-HT release decreased radioligand binding in a dose-dependent fashion with a regional average of 27% after 1 mg/kg and 50% after 5 mg/kg. This preliminary study supports that [ 11C]AZ10419369 is sensitive to endogenous 5-HT levels in vivo and may serve as a tool to examine the pathophysiology and treatment of major psychiatric disorders. © 2010 Wiley-Liss, Inc.
Fenfluramine-induced serotonin release decreases [11C]AZ10419369 binding to 5-HT1B-receptors in the primate brain
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Fenfluramine-induced serotonin release decreases [11C]AZ10419369 binding to 5-HT1B-receptors in the primate brain
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View Export to BibTeX Export to EndNote
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View Export to BibTeX Export to EndNote
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View Export to BibTeX Export to EndNote
Takano A, Gulyas B, Varrone A, Karlsson P, Schou M, Airaksinen AJ, Vandenhende F, Tauscher J, Halldin C
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Impact Factor: 4.532
View Export to BibTeX Export to EndNote
Seneca N, Gulyas B, Varrone A, Schou M, Airaksinen A, Tauscher J, Vandenhende F, Kielbasa W, Farde L, Innis R, Halldin C
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Impact Factor: 3.625
View Export to BibTeX Export to EndNote
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View Export to BibTeX Export to EndNote
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View Export to BibTeX Export to EndNote
20 Records (19 excluding Abstracts).
Total impact factor: 91.914 (90.485 excluding Abstracts).
Total 5 year impact factor: 94.942 (94.048 excluding Abstracts).
Total impact factor: 91.914 (90.485 excluding Abstracts).
Total 5 year impact factor: 94.942 (94.048 excluding Abstracts).
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