Hepatitis C virus infection in ocular adnexal lymphomas(488 views) Strianese D, Tranfa F, Finelli M, De Renzo A, Staibano S, Schiemer R, Cardone D, Pacelli R, Perna F, Mascolo M, De Rosa G, Bonavolonta G
Keywords: Alpha Interferon, Cyclophosphamide, Doxorubicin, Prednisone, Ribavirin, Rituximab, Vincristine Sulfate, Adult, Aged, Article, Cancer Combination Chemotherapy, Cancer Radiotherapy, Cancer Regression, Cancer Relapse, Comparative Study, Disease Association, Disease Course, Disease Free Survival, Female, Hepatitis C, Hepatitis C Virus, Human, Major Clinical Study, Medical Record Review, Nonhodgkin Lymphoma, Ocular Adnexal Nonhodgkin Lymphoma, Outcome Assessment, Overall Survival, Priority Journal, Retrospective Study, Seroprevalence, 80 And Over, Antineoplastic Agents, Conjunctival Neoplasms, Disease-Free Survival, Eye Infections, Eye Neoplasms, Eyelid Neoplasms, Lacrimal Apparatus Diseases, Non-Hodgkin, Middle Aged, Neoplasm Staging, Orbital Neoplasms, Retrospective Studies, Survival Rate, Therapeutic Use, Mortality, Pathology, Virology,
Affiliations: *** IBB - CNR ***
Department of Ophthalmological Sciences, University of Naples Federico II, Via Pansini 5, Naples 80131, Italy
Pathology Section, Department of Biomorphological and Functional Sciences, University of Naples Federico II, Naples, Italy
Department of Diagnostic Imaging and Radiation Oncology, University of Naples Federico II, Naples, Italy
Department of Haematology, University of Naples Federico II, Naples, Italy
References: Not available.
Hepatitis C virus infection in ocular adnexal lymphomas
OBJECTIVE: To assess the influence of hepatitis C virus (HCV) infection on disease appearance and outcome of ocular adnexal non-Hodgkin lymphoma (ONHL). DESIGN: Retrospective comparative study (from January 1, 1992, through December 31, 2006). METHODS: The medical records of 129 patients with ONHL were retrospectively reviewed. All the patients were tested serologically for the presence of HCV infection. Patients were divided into 2 groups according to the presence or absence of HCV infection. MAIN OUTCOME MEASURES: Prevalence of HCV infection, staging to evaluate the extent of disease at the onset, and clinical outcome data on overall and disease-free survival. RESULTS: The prevalence of HCV infection among the patients with ONHL was 17.8%. Seropositivity for HCV infection was significantly associated with extraorbital lymphoma at the onset (P = .006). High prevalence of mucosa-associated lymphoid tissue disease (79.8%) was registered. Protocol therapy included radiotherapy and chemotherapy, depending on the stage of the disease. Complete remission was achieved in 99 patients (76.7%). A total of 23.6% of patients with HCV-seronegative status and 21.7% of those with HCV-seropositive status experienced relapse of the lymphomatous disease. No significant differences in the 5-year overall survival and disease-free survival between the 2 groups were observed. CONCLUSIONS: Prevalence of HCV infection in patients with ONHL is a relevant issue, accounting for 17.8% of the examined patients. Infection with HCV may influence the initial appearance of ONHL because it is associated with more widespread disease at the onset. However, the overall and disease-free survival of the infected patients are not statistically different than that of patients who are not infected.
Hepatitis C virus infection in ocular adnexal lymphomas
No results.
Hepatitis C virus infection in ocular adnexal lymphomas