Hepatitis C virus infection in ocular adnexal lymphomas(337 views) Strianese D, Tranfa F, Finelli M, De Renzo A, Staibano S, Schiemer R, Cardone D, Pacelli R, Perna F, Mascolo M, De Rosa G, Bonavolonta G
Keywords: Alpha Interferon, Cyclophosphamide, Doxorubicin, Prednisone, Ribavirin, Rituximab, Vincristine Sulfate, Adult, Aged, Article, Cancer Combination Chemotherapy, Cancer Radiotherapy, Cancer Regression, Cancer Relapse, Comparative Study, Disease Association, Disease Course, Disease Free Survival, Female, Hepatitis C, Hepatitis C Virus, Human, Major Clinical Study, Medical Record Review, Nonhodgkin Lymphoma, Ocular Adnexal Nonhodgkin Lymphoma, Outcome Assessment, Overall Survival, Priority Journal, Retrospective Study, Seroprevalence, 80 And Over, Antineoplastic Agents, Conjunctival Neoplasms, Disease-Free Survival, Eye Infections, Eye Neoplasms, Eyelid Neoplasms, Lacrimal Apparatus Diseases, Non-Hodgkin, Middle Aged, Neoplasm Staging, Orbital Neoplasms, Retrospective Studies, Survival Rate, Therapeutic Use, Mortality, Pathology, Virology,
Affiliations: *** IBB - CNR ***
Department of Ophthalmological Sciences, University of Naples Federico II, Via Pansini 5, Naples 80131, Italy
Pathology Section, Department of Biomorphological and Functional Sciences, University of Naples Federico II, Naples, Italy
Department of Diagnostic Imaging and Radiation Oncology, University of Naples Federico II, Naples, Italy
Department of Haematology, University of Naples Federico II, Naples, Italy
References: Saito, I., Miyamura, T., Ohbayashi, A., Harada, H., Katayama, T., Kikuchi, S., Watanabe, Y., Kuo, G., Hepatitis C virus infection is associated with the development of hepatocellular carcinoma (1990) Proceedings of the National Academy of Sciences of the United States of America, 87 (17), pp. 6547-654
King, P.D., Wilkes, J.D., Diaz-Arias, A.A., Hepatitis C virus infection in non-Hodgkin's lymphoma (1998) Clin Lab Haematol, 20 (2), pp. 107-110
Luppi, M., Grazia Ferrari, M., Bonaccorsi, G., Hepatitis C virus infection in subsets of neoplastic lymphoproliferations not associated with cryoglobulinemia (1996) Leukemia, 10 (2), pp. 351-355
Gisbert, J.P., Garcia-Buey, L., Pajares, M.J., Moreno-Otero, R., Prevalence of Hepatitis C Virus Infection in B-Cell Non-Hodgkin's Lymphoma: Systematic, Review and Meta-Analysis (2003) Gastroenterology, 125 (6), pp. 1723-1732. , DOI 10.1053/j.gastro.2003.09.025
De Renzo, A., Perna, F., Persico, M., Excellent prognosis and prevalence of HCV infection of primary hepatic and splenic non-Hodgkin's lymphoma (2008) Eur J Haematol, 81 (1), pp. 51-57
Mele, A., Pulsoni, A., Bianco, E., Hepatitis C virus and B-cell non-Hodgkin lymphomas: An Italian multicenter case-control study (2003) Blood, 102 (3), pp. 996-999
Duberg, A.-S., Nordström, M., Törner, A., Non-Hodgkin's lymphoma and other nonhepatic malignancies in Swedish patients with hepatitis C virus infection (2005) Hepatology, 41 (3), pp. 652-659
Takeshita, M., Sakai, H., Okamura, S., Prevalence of hepatitis C virus infection in cases of B-cell lymphoma in Japan (2006) Histopathology, 48 (2), pp. 189-198
Morgensztern, D., Rosado, M.F., Silva, O., Santos, E.S., Abdullah, S.A., Goodman, M., Hamilton-Nelson, K., Lossos, I.S., Prevalence of hepatitis C infection in patients with non-Hodgkin's lymphoma in South Florida and review of the literature (2004) Leukemia and Lymphoma, 45 (12), pp. 2459-2464. , DOI 10.1080/10428190400007771
Ferreri, A.J.M., Viale, E., Guidoboni, M., Clinical implications of hepatitis C virus infection in MALT-type lymphoma of the ocular adnexa (2006) Ann Oncol, 17 (5), pp. 769-772
Grunberger, B., Wohrer, S., Streubel, B., Formanek, M., Petkov, V., Puespoek, A., Haefner, M., Raderer, M., Antibiotic treatment is not effective in patients infected with Helicobacter pylori suffering from extragastric MALT lymphoma (2006) Journal of Clinical Oncology, 24 (9), pp. 1370-1375. , DOI 10.1200/JCO.2005.02.9025
Gruenberger, B., Woehrer, S., Troch, M., Assessment of the role of hepatitis C, Helicobacter pylori and autoimmunity in MALT lymphoma of the ocular adnexa in 45 Austrian patients (2008) Acta Oncol, 47 (3), pp. 355-359
Arnaud, P., Escande, M.-C., Lecuit, M., Hepatitis C virus infection and MALTtype ocular adnexal lymphoma (2007) Ann Oncol, 18 (2), pp. 400-403
Svoboda, J., Andreadis, C., Downs, L.H., Miller Jr., W.T., Tsai, D.E., Schuster, S.J., Regression of advanced non-splenic marginal zone lymphoma after treatment of hepatitis C virus infection (2005) Leukemia and Lymphoma, 46 (9), pp. 1365-1368. , DOI 10.1080/104281905001028289
Harris, N.L., Jaffe, E.S., Diebold, J., World Health Organization classification of neoplastic diseases of the hematopoietic and lymphoid tissues: Report of the Clinical Advisory Committee meeting-Airlie House, Virginia, November 1997 (1999) J Clin Oncol, 17 (12), pp. 3835-3849
Ishak, K., Baptista, A., Bianchi, L., Histological grading and staging of chronic hepatitis (1995) J Hepatol, 22 (6), pp. 696-699
Besson, C., Canioni, D., Lepage, E., Characteristics and outcome of diffuse large B-cell lymphoma in hepatitis C virus-positive patients in LNH 93 and LNH 98 Groupe d'Etude des Lymphomes de l'Adulte programs (2006) J Clin Oncol, 24 (6), pp. 953-960. , Groupe d'Etude des Lymphomes de l'Adulte Programs
Verma, V., Shen, D., Sieving, P.C., Chan, C.C., The role of infectious agents in the etiology of ocular adnexal neoplasia (2008) Surv Ophthalmol, 53 (4), pp. 312-331
Ferreri, A.J.M., Guidoboni, M., Ponzoni, M., Evidence for an association between Chlamydia psittaci and ocular adnexal lymphomas (2004) J Natl Cancer Inst, 96 (8), pp. 586-594
Chanudet, E., Zhou, Y., Bacon, C.M., Chlamydia psittaci is variably associated with ocular adnexal MALT lymphoma in different geographical regions (2006) J Pathol, 209 (3), pp. 344-351
Machida, K., Cheng, K.T.-N., Sung, V.M.-H., Shimodaira, S., Lindsay, K.L., Levinet, A.M., Lai, M.-Y., Lai, M.M.C., Hepatitis C virus induces a mutator phenotype: Enhanced mutations of immunoglobulin and protooncogenes (2004) Proceedings of the National Academy of Sciences of the United States of America, 101 (12), pp. 4262-4267. , DOI 10.1073/pnas.0303971101
Chan, C.H., Hadlock, K.G., Foung, S.K.H., Levy, S., V(H)1-69 gene is preferentially used by hepatitis C virus-associated B cell lymphomas and by normal B cells responding to the E2 viral antigen (2001) Blood, 97 (4), pp. 1023-1026
Marasca, R., Vaccari, P., Luppi, M., Immunoglobulin gene mutations and frequent use of VH1-69 and VH4-34 segments in hepatitis C virus-positive and hepatitis C virus-negative nodal marginal zone B-cell lymphoma (2001) Am J Pathol, 159 (1), pp. 253-261
Hermine, O., Lefrere, F., Bronowicki, J.-P., Mariette, X., Jondeau, K., Eclache-Saudreau, V., Delmas, B., Troussard, X., Regression of splenic lymphoma with villous lymphocytes after treatment of hepatitis C virus infection (2002) New England Journal of Medicine, 347 (2), pp. 89-94. , DOI 10.1056/NEJMoa013376
La Mura, V., De Renzo, A., Perna, F., Antiviral therapy after complete response to chemotherapy could be efficacious in HCV-positive non-Hodgkin's lymphoma (2008) J Hepatol, 49 (4), pp. 557-563
Vallisa, D., Bernuzzi, P., Arcaini, L., Role of anti-hepatitis C virus (HCV) treatment in HCV-related, low-grade, B-cell, non-Hodgkin's lymphoma: A multicenter Italian experience (2005) J Clin Oncol, 23 (3), pp. 468-473
King, P. D., Wilkes, J. D., Diaz-Arias, A. A., Hepatitis C virus infection in non-Hodgkin's lymphoma (1998) Clin Lab Haematol, 20 (2), pp. 107-110
Gisbert, J. P., Garcia-Buey, L., Pajares, M. J., Moreno-Otero, R., Prevalence of Hepatitis C Virus Infection in B-Cell Non-Hodgkin's Lymphoma: Systematic, Review and Meta-Analysis (2003) Gastroenterology, 125 (6), pp. 1723-1732. , DOI 10. 1053/j. gastro. 2003. 09. 025
Duberg, A. -S., Nordstr m, M., T rner, A., Non-Hodgkin's lymphoma and other nonhepatic malignancies in Swedish patients with hepatitis C virus infection (2005) Hepatology, 41 (3), pp. 652-659
Ferreri, A. J. M., Viale, E., Guidoboni, M., Clinical implications of hepatitis C virus infection in MALT-type lymphoma of the ocular adnexa (2006) Ann Oncol, 17 (5), pp. 769-772
Harris, N. L., Jaffe, E. S., Diebold, J., World Health Organization classification of neoplastic diseases of the hematopoietic and lymphoid tissues: Report of the Clinical Advisory Committee meeting-Airlie House, Virginia, November 1997 (1999) J Clin Oncol, 17 (12), pp. 3835-3849
Chan, C. H., Hadlock, K. G., Foung, S. K. H., Levy, S., V (H) 1-69 gene is preferentially used by hepatitis C virus-associated B cell lymphomas and by normal B cells responding to the E2 viral antigen (2001) Blood, 97 (4), pp. 1023-1026
Hepatitis C virus infection in ocular adnexal lymphomas
OBJECTIVE: To assess the influence of hepatitis C virus (HCV) infection on disease appearance and outcome of ocular adnexal non-Hodgkin lymphoma (ONHL). DESIGN: Retrospective comparative study (from January 1, 1992, through December 31, 2006). METHODS: The medical records of 129 patients with ONHL were retrospectively reviewed. All the patients were tested serologically for the presence of HCV infection. Patients were divided into 2 groups according to the presence or absence of HCV infection. MAIN OUTCOME MEASURES: Prevalence of HCV infection, staging to evaluate the extent of disease at the onset, and clinical outcome data on overall and disease-free survival. RESULTS: The prevalence of HCV infection among the patients with ONHL was 17.8%. Seropositivity for HCV infection was significantly associated with extraorbital lymphoma at the onset (P = .006). High prevalence of mucosa-associated lymphoid tissue disease (79.8%) was registered. Protocol therapy included radiotherapy and chemotherapy, depending on the stage of the disease. Complete remission was achieved in 99 patients (76.7%). A total of 23.6% of patients with HCV-seronegative status and 21.7% of those with HCV-seropositive status experienced relapse of the lymphomatous disease. No significant differences in the 5-year overall survival and disease-free survival between the 2 groups were observed. CONCLUSIONS: Prevalence of HCV infection in patients with ONHL is a relevant issue, accounting for 17.8% of the examined patients. Infection with HCV may influence the initial appearance of ONHL because it is associated with more widespread disease at the onset. However, the overall and disease-free survival of the infected patients are not statistically different than that of patients who are not infected.
Hepatitis C virus infection in ocular adnexal lymphomas
No results.
Hepatitis C virus infection in ocular adnexal lymphomas