NMR backbone dynamics studies of human PED/PEA-15 outline protein functional sites (720 views)
Febs J (ISSN: 1742-4658, 1742-464x, 1742-4658electronic), 2010 Oct; 277(20): 4229-4240.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 3.129, 5-year impact factor: 3.2
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-77957259676&partnerID=40&md5=283401564488e181215077003f038f0e
Keywords: Backbone Dynamics, Death Domain, Nmr Spectroscopy, Pedpea-15 Protein, Protein-Protein Interactions, Nitrogen 15, Phosphoprotein, Phosphoprotein Enriched In Diabetes Phosphoprotein Enriched In Astrocytes, Unclassified Drug, Animal Cell, Article, Human, Molecular Dynamics, Nitrogen Nuclear Magnetic Resonance, Nonhuman, Nuclear Overhauser Effect, Priority Journal, Protein Binding, Protein Domain, Protein Function, Protein Protein Interaction, Spectrometry, Steady State, Intracellular Signaling Peptides And Proteins, Magnetic Resonance Spectroscopy, Molecular Dynamics Simulation, Chemistry, Metabolism, Methods,
Affiliations:
*** IBB - CNR ***
Istituto di Biostrutture e Bioimmagini, CNR, Napoli, Italy.
Dipartimento di Scienze Ambientali, Seconda Universit di Napoli, Via Vivaldi 43, 81100 Caserta, Italy
Dipartimento Delle Scienze Biologiche, Universit di Napoli Federico II, Napoli, Italy
References:
Araujo, H., Danziger, N., Cordier, J., Glowinski, J., Chneiweiss, H., Characterization of PEA-15, a major substrate for protein kinase C in astrocytes (1993) Journal of Biological Chemistry, 268 (8), pp. 5911-592
Estelles, A., Yokoyama, M., Nothias, F., Vincent, J. -D., Glowinski, J., Vernier, P., Chneiweiss, H., The major astrocytic phosphoprotein PEA-15 is encoded by two mRNAs conserved on their full length in mouse and human (1996) Journal of Biological Chemistry, 271 (25), pp. 14800-14806. , DOI 10. 1074/jbc. 271. 25. 14800
Fiory, F., Formisano, P., Perruolo, G., Beguinot, F., Frontiers: PEDPEA-15, a multifunctional protein controlling cell survival and glucose metabolism (2009) Am J Physiol Endocrinol Metab, 297, pp. E592-E601
Eberstadt, M., Huang, B., Chen, Z., Meadows, R. P., Ng, S. -C., Zheng, L., Lenardo, M. J., Fesik, S. W., NMR structure and mutagenesis of the FADD (Mort 1) death-effector domain (1998) Nature, 392 (6679), pp. 941-945. , DOI 10. 1038/31972
Hofmann, K., The modular nature of apoptotic signaling proteins (1999) Cellular and Molecular Life Sciences, 55 (8-9), pp. 1113-1128
Fesik, S. W., Insights into programmed cell death through structural biology (2000) Cell, 103, pp. 273-282
Aravind, L., Dixit, V. M., Koonin, E. V., The domains of death: Evolution of the apoptosis machinery (1999) Trends in Biochemical Sciences, 24 (2), pp. 47-53. , DOI 10. 1016/S0968-0004 (98) 01341-3, PII S0968000498013413
Valmiki, M. G., Ramos, J. W., Death effector domain-containing proteins (2009) Cell Mol Life Sci, 66, pp. 814-830
Park, H. H., Logette, E., Raunser, S., Cuenin, S., Walz, T., Tschopp, J., Wu, H., Death domain assembly mechanism revealed by crystal structure of the oligomeric PIDDosome core complex (2007) Cell, 128 (3), pp. 533-546. , DOI 10. 1016/j. cell. 2007. 01. 019, PII S009286740700116X
Condorelli, G., Vigliotta, G., Cafieri, A., Trencia, A., Andalo, P., Oriente, F., Miele, C., Beguinot, F., PED/PEA-15: An anti-apoptotic molecule that regulates FAS/TNFR1-induced apoptosis (1999) Oncogene, 18 (31), pp. 4409-4415. , DOI 10. 1038/sj. onc. 1202831
Kitsberg, D., Formstecher, E., Fauquet, M., Kubes, M., Cordier, J., Canton, B., Pan, G., Chneiweiss, H., Knock-out of the neural death effector domain protein PEA-15 demonstrates that its expression protects astrocytes from TNF -induced apoptosis (1999) Journal of Neuroscience, 19 (19), pp. 8244-8251
Formstecher, E., Ramos, J. W., Fauquet, M., Calderwood, D. A., Hsieh, J. -C., Canton, B., Nguyen, X. -T., Chneiweiss, H., PEA-15 mediates cytoplasmic sequestration of ERK MAP kinase (2001) Developmental Cell, 1 (2), pp. 239-250. , DOI 10. 1016/S1534-5807 (01) 00035-1
Hill, J. M., Vaidyanathan, H., Ramos, J. W., Ginsberg, M. H., Werner, M. H., Recognition of ERK MAP kinase by PEA-15 reveals a common docking site within the death domain and death effector domain (2002) EMBO Journal, 21 (23), pp. 6494-6504. , DOI 10. 1093/emboj/cdf641
Callaway, K., Abramczyk, O., Martin, L., Dalby, K. N., The anti-apoptotic protein PEA-15 is a tight binding inhibitor of ERK1 and ERK2, which blocks docking interactions at the D-recruitment site (2007) Biochemistry, 46 (32), pp. 9187-9198. , DOI 10. 1021/bi700206u
Vaidyanathan, H., Opoku-Ansah, J., Pastorino, S., Renganathan, H., Matter, M. L., Ramos, J. W., ERK MAP kinase is targeted to RSK2 by the phosphoprotein PEA-15 (2007) Proc Natl Acad Sci USA, 104, pp. 19837-19842
Glading, A., Koziol, J. A., Krueger, J., Ginsberg, M. H., PEA-15 inhibits tumor cell invasion by binding to extracellular signal-regulated kinase 1/2 (2007) Cancer Research, 67 (4), pp. 1536-1544. , DOI 10. 1158/0008-5472. CAN-06-1378
Valentino, R., Lupoli, G. A., Raciti, G. A., Oriente, F., Farinaro, E., Della Valle, E., Salomone, M., Beguinot, F., The PEA15 gene is overexpressed and related to insulin resistance in healthy first-degree relatives of patients with type 2 diabetes (2006) Diabetologia, 49 (12), pp. 3058-3066. , DOI 10. 1007/s00125-006-0455-5
Vigliotta, G., Miele, C., Santopietro, S., Portella, G., Perfetti, A., Maitan, M. A., Cassese, A., Beguinot, F., Overexpression of the ped/pea-15 gene causes diabetes by impairing glucose-stimulated insulin secretion in addition to insulin action (2004) Molecular and Cellular Biology, 24 (11), pp. 5005-5015. , DOI 10. 1128/MCB. 24. 11. 5005-5015. 2004
Miele, C., Raciti, G. A., Cassese, A., Romano, C., Giacco, F., Oriente, F., Paturzo, F., Beguinot, F., PED/PEA-15 regulates glucose-induced insulin secretion by restraining potassium channel expression in pancreatic -cells (2007) Diabetes, 56 (3), pp. 622-633. , http: //diabetes. diabetesjournals. org/cgi/reprint/56/3/622. pdf, DOI 10. 2337/db06-1260
Viparelli, F., Cassese, A., Doti, N., Paturzo, F., Marasco, D., Dathan, N. A., Monti, S. M., Sabatella, M., Targeting of PEDPEA-15 molecular interaction with phospholipase D1 enhances insulin sensitivity in skeletal muscle cells (2008) J Biol Chem, 283, pp. 21769-21778
Zhang, Y., Redina, O., Altshuller, Y. M., Yamazaki, M., Ramos, J., Chneiweiss, H., Kanaho, Y., Frohman, M. A., Regulation of expression of phospholipase D1 and D2 by PEA-15, a novel protein that interacts with them (2000) J Biol Chem, 275, pp. 35224-35232
Renganathan, H., Vaidyanathan, H., Knapinska, A., Ramos, J. W., Phosphorylation of PEA-15 switches its binding specificity from ERK/MAPK to FADD (2005) Biochemical Journal, 390 (3), pp. 729-735. , DOI 10. 1042/BJ20050378
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MacIejewski, M. W., Liu, D., Prasad, R., Wilson, S. H., Mullen, G. P., Backbone dynamics and refined solution structure of the N-terminal domain of DNA polymerase beta. Correlation with DNA binding and dRP lyase activity (2000) J Mol Biol, 296, pp. 229-253
Lee, L. K., Rance, M., Chazin, W. J., Palmer III, A. G., Rotational diffusion anisotropy of proteins from simultaneous analysis of 15N and 13C alpha nuclear spin relaxation (1997) J Biomol NMR, 9, pp. 287-298
Kay, L. E., Torchia, D. A., Bax, A., Backbone dynamics of proteins as studied by 15N inverse detected heteronuclear NMR spectroscopy: Application to staphylococcal nuclease (1989) Biochemistry, 28 (23), pp. 8972-8979
Farrow, N. A., Zhang, O., Forman-Kay, J. D., Kay, L. E., Comparison of the backbone dynamics of a folded and an unfolded SH3 domain existing in equilibrium in aqueous buffer (1995) Biochemistry, 34, pp. 868-878
Viles, J. H., Donne, D., Kroon, G., Prusiner, S. B., Cohen, F. E., Dyson, H. J., Wright, P. E., Local structural plasticity of the prion protein. Analysis of NMR relaxation dynamics (2001) Biochemistry, 40 (9), pp. 2743-2753. , DOI 10. 1021/bi002898a
Bhattacharya, N., Yi, M., Zhou, H. -X., Logan, T. M., Backbone Dynamics in an Intramolecular Prolylpeptide-SH3 Complex from the Diphtheria Toxin Repressor, DtxR (2007) Journal of Molecular Biology, 374 (4), pp. 977-992. , DOI 10. 1016/j. jmb. 2007. 09. 063, PII S0022283607012636
Lefevre, J. -F., Dayie, K. T., Peng, J. W., Wagner, G., Internal mobility in the partially folded DNA binding and dimerization domains of GAL4: NMR analysis of the N-H spectral density functions (1996) Biochemistry, 35 (8), pp. 2674-2686. , DOI 10. 1021/bi9526802
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Feher, V. A., Cavanagh, J., Millisecond-timescale motions contribute to the function of the bacterial response regulator protein Spo0F (1999) Nature, 400 (6741), pp. 289-293. , DOI 10. 1038/22357
Ferreon, J. C., Hilser, V. J., Ligand-induced changes in dynamics in the RT loop of the C-terminal SH3 domain of Sem-5 indicate cooperative conformational coupling (2003) Protein Sci, 12, pp. 982-996
Carrington, P. E., Sandu, C., Wei, Y., Hill, J. M., Morisawa, G., Huang, T., Gavathiotis, E., Werner, M. H., The structure of FADD and its mode of interaction with procaspase-8 (2006) Molecular Cell, 22 (5), pp. 599-610. , DOI 10. 1016/j. molcel. 2006. 04. 018, PII S1097276506002668
Yang, J. K., Wang, L., Zheng, L., Wan, F., Ahmed, M., Lenardo, M. J., Wu, H., Crystal structure of MC159 reveals molecular mechanism of DISC assembly and FLIP inhibition (2005) Molecular Cell, 20 (6), pp. 939-949. , DOI 10. 1016/j. molcel. 2005. 10. 023, PII S1097276505017181
Li, F. -Y., Jeffrey, P. D., Yu, J. W., Shi, Y., Crystal structure of a viral FLIP: Insights into FLIP-mediated inhibition of death receptor signaling (2006) Journal of Biological Chemistry, 281 (5), pp. 2960-2968. , http: //www. jbc. org/cgi/reprint/281/5/2960. pdf, DOI 10. 1074/jbc. M511074200
Bertin, J., Armstrong, R. C., Ottilie, S., Martin, D. A., Wang, Y., Banks, S., Wang, G. -H., Cohen, J. I., Death effector domain-containing herpesvirus and poxvirus proteins inhibit both Fas- and TNFR1-induced apoptosis (1997) Proceedings of the National Academy of Sciences of the United States of America, 94 (4), pp. 1172-1176. , DOI 10. 1073/pnas. 94. 4. 1172
Shisler, J. L., Moss, B., Molluscum contagiosum virus inhibitors of apoptosis: The MC159 v-FLIP protein blocks Fas-induced activation of procaspases and degradation of the related MC160 protein (2001) Virology, 282 (1), pp. 14-25. , DOI 10. 1006/viro. 2001. 0834
Xu, Z., Tang, K., Wang, M., Rao, Q., Liu, B., Wang, J., A new caspase-8 isoform caspase-8s increased sensitivity to apoptosis in Jurkat cells (2009) J Biomed Biotechnol, 2009, pp. 1-10
Viparelli, F., Doti, N., Sandomenico, A., Marasco, D., Dathan, N. A., Miele, C., Beguinot, F., Ruvo, M., Expression and purification of the D4 region of PLD1 and characterization of its interaction with PED-PEA15 (2008) Protein Expr Purif, 59, pp. 302-308
Palmer, A. G., Rance, M., Wright, P. E., Intramolecular motions of a zinc finger DNA-binding domain from Xfin characterized by proton-detected natural abundance carbon-13 heteronuclear NMR spectroscopy (1991) J Am Chem Soc, 113, pp. 4371-4380
Mandel, A. M., Akke, M., Palmer III, A. G., Backbone dynamics of Escherichia coli ribonuclease HI: Correlations with structure and function in an active enzyme (1995) J Mol Biol, 246, pp. 144-163
Tjandra, N., Feller, S. E., Pastor, R. W., Bax, A., Rotational diffusion anisotropy of human ubiquitin from 15N NMR relaxation (1995) Journal of the American Chemical Society, 117 (50), pp. 12562-12566. , DOI 10. 1021/ja00155a020
D'Auvergne, E. J., Gooley, P. R., The use of model selection in the model-free analysis of protein dynamics (2003) Journal of Biomolecular NMR, 25 (1), pp. 25-39. , DOI 10. 1023/A: 1021902006114
Farrow, N. A., Muhandiram, R., Singer, A. U., Pascal, S. M., Kay, C. M., Gish, G., Shoelson, S. E., Kay, L. E., Backbone dynamics of a free and a phosphopeptide-complexed src homology 2 domain studied by 15N NMR relaxation (1994) Biochemistry, 33 (19), pp. 5984-6003. , DOI 10. 1021/bi00185a040
Koradi, R., Billeter, M., Wuthrich, K., MOLMOL: A program for display and analysis of macromolecular structures (1996) Journal of Molecular Graphics, 14 (1), pp. 51-55. , DOI 10. 1016/0263-7855 (96) 00009-4
Fesik, S.W., Insights into programmed cell death through structural biology (2000) Cell, 103, pp. 273-282
Valmiki, M.G., Ramos, J.W., Death effector domain-containing proteins (2009) Cell Mol Life Sci, 66, pp. 814-830
Park, H.H., Logette, E., Raunser, S., Cuenin, S., Walz, T., Tschopp, J., Wu, H., Death domain assembly mechanism revealed by crystal structure of the oligomeric PIDDosome core complex (2007) Cell, 128 (3), pp. 533-546. , DOI 10.1016/j.cell.2007.01.019, PII S009286740700116X
Hill, J.M., Vaidyanathan, H., Ramos, J.W., Ginsberg, M.H., Werner, M.H., Recognition of ERK MAP kinase by PEA-15 reveals a common docking site within the death domain and death effector domain (2002) EMBO Journal, 21 (23), pp. 6494-6504. , DOI 10.1093/emboj/cdf641
Peng, J.W., Wagner, G., Mapping of the spectral densities of N-H bond motions in eglin c using heteronuclear relaxation experiments (1992) Biochemistry, 31, pp. 8571-8586
García De La Torre, J., Huertas, M.L., Carrasco, B., HYDRONMR: Prediction of NMR Relaxation of Globular Proteins from Atomic-Level Structures and Hydrodynamic Calculations (2000) J Magn Res, 147, pp. 138-146
Pawley, N.H., Wang, C., Koide, S., Nicholson, L.K., An improved method for distinguishing between anisotropic tumbling and chemical exchange in analysis of 15N relaxation parameters (2001) Journal of Biomolecular NMR, 20 (2), pp. 149-165. , DOI 10.1023/A:1011249816560
MacIejewski, M.W., Liu, D., Prasad, R., Wilson, S.H., Mullen, G.P., Backbone dynamics and refined solution structure of the N-terminal domain of DNA polymerase beta. Correlation with DNA binding and dRP lyase activity (2000) J Mol Biol, 296, pp. 229-253
Lee, L.K., Rance, M., Chazin, W.J., Palmer III, A.G., Rotational diffusion anisotropy of proteins from simultaneous analysis of 15N and 13C alpha nuclear spin relaxation (1997) J Biomol NMR, 9, pp. 287-298
Kay, L.E., Torchia, D.A., Bax, A., Backbone dynamics of proteins as studied by 15N inverse detected heteronuclear NMR spectroscopy: Application to staphylococcal nuclease (1989) Biochemistry, 28 (23), pp. 8972-8979
Farrow, N.A., Zhang, O., Forman-Kay, J.D., Kay, L.E., Comparison of the backbone dynamics of a folded and an unfolded SH3 domain existing in equilibrium in aqueous buffer (1995) Biochemistry, 34, pp. 868-878
Viles, J.H., Donne, D., Kroon, G., Prusiner, S.B., Cohen, F.E., Dyson, H.J., Wright, P.E., Local structural plasticity of the prion protein. Analysis of NMR relaxation dynamics (2001) Biochemistry, 40 (9), pp. 2743-2753. , DOI 10.1021/bi002898a
Lefevre, J.-F., Dayie, K.T., Peng, J.W., Wagner, G., Internal mobility in the partially folded DNA binding and dimerization domains of GAL4:NMR analysis of the N-H spectral density functions (1996) Biochemistry, 35 (8), pp. 2674-2686. , DOI 10.1021/bi9526802
Boehr, D.D., Nussinov, R., Wright, P.E., The role of dynamic conformational ensembles in biomolecular recognition (2009) Nat Chem Biol, 5, pp. 789-796
Feher, V.A., Cavanagh, J., Millisecond-timescale motions contribute to the function of the bacterial response regulator protein Spo0F (1999) Nature, 400 (6741), pp. 289-293. , DOI 10.1038/22357
Ferreon, J.C., Hilser, V.J., Ligand-induced changes in dynamics in the RT loop of the C-terminal SH3 domain of Sem-5 indicate cooperative conformational coupling (2003) Protein Sci, 12, pp. 982-996
Carrington, P.E., Sandu, C., Wei, Y., Hill, J.M., Morisawa, G., Huang, T., Gavathiotis, E., Werner, M.H., The structure of FADD and its mode of interaction with procaspase-8 (2006) Molecular Cell, 22 (5), pp. 599-610. , DOI 10.1016/j.molcel.2006.04.018, PII S1097276506002668
Yang, J.K., Wang, L., Zheng, L., Wan, F., Ahmed, M., Lenardo, M.J., Wu, H., Crystal structure of MC159 reveals molecular mechanism of DISC assembly and FLIP inhibition (2005) Molecular Cell, 20 (6), pp. 939-949. , DOI 10.1016/j.molcel.2005.10.023, PII S1097276505017181
Li, F.-Y., Jeffrey, P.D., Yu, J.W., Shi, Y., Crystal structure of a viral FLIP: Insights into FLIP-mediated inhibition of death receptor signaling (2006) Journal of Biological Chemistry, 281 (5), pp. 2960-2968. , http://www.jbc.org/cgi/reprint/281/5/2960.pdf, DOI 10.1074/jbc.M511074200
Shisler, J.L., Moss, B., Molluscum contagiosum virus inhibitors of apoptosis: The MC159 v-FLIP protein blocks Fas-induced activation of procaspases and degradation of the related MC160 protein (2001) Virology, 282 (1), pp. 14-25. , DOI 10.1006/viro.2001.0834
Palmer, A.G., Rance, M., Wright, P.E., Intramolecular motions of a zinc finger DNA-binding domain from Xfin characterized by proton-detected natural abundance carbon-13 heteronuclear NMR spectroscopy (1991) J Am Chem Soc, 113, pp. 4371-4380
Mandel, A.M., Akke, M., Palmer III, A.G., Backbone dynamics of Escherichia coli ribonuclease HI: Correlations with structure and function in an active enzyme (1995) J Mol Biol, 246, pp. 144-163
D'Auvergne, E.J., Gooley, P.R., The use of model selection in the model-free analysis of protein dynamics (2003) Journal of Biomolecular NMR, 25 (1), pp. 25-39. , DOI 10.1023/A:1021902006114
Farrow, N.A., Muhandiram, R., Singer, A.U., Pascal, S.M., Kay, C.M., Gish, G., Shoelson, S.E., Kay, L.E., Backbone dynamics of a free and a phosphopeptide-complexed src homology 2 domain studied by 15N NMR relaxation (1994) Biochemistry, 33 (19), pp. 5984-6003. , DOI 10.1021/bi00185a040
Febs J (ISSN: 1742-4658, 1742-464x, 1742-4658electronic), 2010 Oct; 277(20): 4229-4240.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 3.129, 5-year impact factor: 3.2
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-77957259676&partnerID=40&md5=283401564488e181215077003f038f0e
Keywords: Backbone Dynamics, Death Domain, Nmr Spectroscopy, Pedpea-15 Protein, Protein-Protein Interactions, Nitrogen 15, Phosphoprotein, Phosphoprotein Enriched In Diabetes Phosphoprotein Enriched In Astrocytes, Unclassified Drug, Animal Cell, Article, Human, Molecular Dynamics, Nitrogen Nuclear Magnetic Resonance, Nonhuman, Nuclear Overhauser Effect, Priority Journal, Protein Binding, Protein Domain, Protein Function, Protein Protein Interaction, Spectrometry, Steady State, Intracellular Signaling Peptides And Proteins, Magnetic Resonance Spectroscopy, Molecular Dynamics Simulation, Chemistry, Metabolism, Methods,
Affiliations:
*** IBB - CNR ***
Istituto di Biostrutture e Bioimmagini, CNR, Napoli, Italy.
Dipartimento di Scienze Ambientali, Seconda Universit di Napoli, Via Vivaldi 43, 81100 Caserta, Italy
Dipartimento Delle Scienze Biologiche, Universit di Napoli Federico II, Napoli, Italy
References:
Araujo, H., Danziger, N., Cordier, J., Glowinski, J., Chneiweiss, H., Characterization of PEA-15, a major substrate for protein kinase C in astrocytes (1993) Journal of Biological Chemistry, 268 (8), pp. 5911-592
Estelles, A., Yokoyama, M., Nothias, F., Vincent, J. -D., Glowinski, J., Vernier, P., Chneiweiss, H., The major astrocytic phosphoprotein PEA-15 is encoded by two mRNAs conserved on their full length in mouse and human (1996) Journal of Biological Chemistry, 271 (25), pp. 14800-14806. , DOI 10. 1074/jbc. 271. 25. 14800
Fiory, F., Formisano, P., Perruolo, G., Beguinot, F., Frontiers: PEDPEA-15, a multifunctional protein controlling cell survival and glucose metabolism (2009) Am J Physiol Endocrinol Metab, 297, pp. E592-E601
Eberstadt, M., Huang, B., Chen, Z., Meadows, R. P., Ng, S. -C., Zheng, L., Lenardo, M. J., Fesik, S. W., NMR structure and mutagenesis of the FADD (Mort 1) death-effector domain (1998) Nature, 392 (6679), pp. 941-945. , DOI 10. 1038/31972
Hofmann, K., The modular nature of apoptotic signaling proteins (1999) Cellular and Molecular Life Sciences, 55 (8-9), pp. 1113-1128
Fesik, S. W., Insights into programmed cell death through structural biology (2000) Cell, 103, pp. 273-282
Aravind, L., Dixit, V. M., Koonin, E. V., The domains of death: Evolution of the apoptosis machinery (1999) Trends in Biochemical Sciences, 24 (2), pp. 47-53. , DOI 10. 1016/S0968-0004 (98) 01341-3, PII S0968000498013413
Valmiki, M. G., Ramos, J. W., Death effector domain-containing proteins (2009) Cell Mol Life Sci, 66, pp. 814-830
Park, H. H., Logette, E., Raunser, S., Cuenin, S., Walz, T., Tschopp, J., Wu, H., Death domain assembly mechanism revealed by crystal structure of the oligomeric PIDDosome core complex (2007) Cell, 128 (3), pp. 533-546. , DOI 10. 1016/j. cell. 2007. 01. 019, PII S009286740700116X
Condorelli, G., Vigliotta, G., Cafieri, A., Trencia, A., Andalo, P., Oriente, F., Miele, C., Beguinot, F., PED/PEA-15: An anti-apoptotic molecule that regulates FAS/TNFR1-induced apoptosis (1999) Oncogene, 18 (31), pp. 4409-4415. , DOI 10. 1038/sj. onc. 1202831
Kitsberg, D., Formstecher, E., Fauquet, M., Kubes, M., Cordier, J., Canton, B., Pan, G., Chneiweiss, H., Knock-out of the neural death effector domain protein PEA-15 demonstrates that its expression protects astrocytes from TNF -induced apoptosis (1999) Journal of Neuroscience, 19 (19), pp. 8244-8251
Formstecher, E., Ramos, J. W., Fauquet, M., Calderwood, D. A., Hsieh, J. -C., Canton, B., Nguyen, X. -T., Chneiweiss, H., PEA-15 mediates cytoplasmic sequestration of ERK MAP kinase (2001) Developmental Cell, 1 (2), pp. 239-250. , DOI 10. 1016/S1534-5807 (01) 00035-1
Hill, J. M., Vaidyanathan, H., Ramos, J. W., Ginsberg, M. H., Werner, M. H., Recognition of ERK MAP kinase by PEA-15 reveals a common docking site within the death domain and death effector domain (2002) EMBO Journal, 21 (23), pp. 6494-6504. , DOI 10. 1093/emboj/cdf641
Callaway, K., Abramczyk, O., Martin, L., Dalby, K. N., The anti-apoptotic protein PEA-15 is a tight binding inhibitor of ERK1 and ERK2, which blocks docking interactions at the D-recruitment site (2007) Biochemistry, 46 (32), pp. 9187-9198. , DOI 10. 1021/bi700206u
Vaidyanathan, H., Opoku-Ansah, J., Pastorino, S., Renganathan, H., Matter, M. L., Ramos, J. W., ERK MAP kinase is targeted to RSK2 by the phosphoprotein PEA-15 (2007) Proc Natl Acad Sci USA, 104, pp. 19837-19842
Glading, A., Koziol, J. A., Krueger, J., Ginsberg, M. H., PEA-15 inhibits tumor cell invasion by binding to extracellular signal-regulated kinase 1/2 (2007) Cancer Research, 67 (4), pp. 1536-1544. , DOI 10. 1158/0008-5472. CAN-06-1378
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Vigliotta, G., Miele, C., Santopietro, S., Portella, G., Perfetti, A., Maitan, M. A., Cassese, A., Beguinot, F., Overexpression of the ped/pea-15 gene causes diabetes by impairing glucose-stimulated insulin secretion in addition to insulin action (2004) Molecular and Cellular Biology, 24 (11), pp. 5005-5015. , DOI 10. 1128/MCB. 24. 11. 5005-5015. 2004
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Ferreon, J.C., Hilser, V.J., Ligand-induced changes in dynamics in the RT loop of the C-terminal SH3 domain of Sem-5 indicate cooperative conformational coupling (2003) Protein Sci, 12, pp. 982-996
Carrington, P.E., Sandu, C., Wei, Y., Hill, J.M., Morisawa, G., Huang, T., Gavathiotis, E., Werner, M.H., The structure of FADD and its mode of interaction with procaspase-8 (2006) Molecular Cell, 22 (5), pp. 599-610. , DOI 10.1016/j.molcel.2006.04.018, PII S1097276506002668
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Shisler, J.L., Moss, B., Molluscum contagiosum virus inhibitors of apoptosis: The MC159 v-FLIP protein blocks Fas-induced activation of procaspases and degradation of the related MC160 protein (2001) Virology, 282 (1), pp. 14-25. , DOI 10.1006/viro.2001.0834
Palmer, A.G., Rance, M., Wright, P.E., Intramolecular motions of a zinc finger DNA-binding domain from Xfin characterized by proton-detected natural abundance carbon-13 heteronuclear NMR spectroscopy (1991) J Am Chem Soc, 113, pp. 4371-4380
Mandel, A.M., Akke, M., Palmer III, A.G., Backbone dynamics of Escherichia coli ribonuclease HI: Correlations with structure and function in an active enzyme (1995) J Mol Biol, 246, pp. 144-163
D'Auvergne, E.J., Gooley, P.R., The use of model selection in the model-free analysis of protein dynamics (2003) Journal of Biomolecular NMR, 25 (1), pp. 25-39. , DOI 10.1023/A:1021902006114
Farrow, N.A., Muhandiram, R., Singer, A.U., Pascal, S.M., Kay, C.M., Gish, G., Shoelson, S.E., Kay, L.E., Backbone dynamics of a free and a phosphopeptide-complexed src homology 2 domain studied by 15N NMR relaxation (1994) Biochemistry, 33 (19), pp. 5984-6003. , DOI 10.1021/bi00185a040
NMR backbone dynamics studies of human PED/PEA-15 outline protein functional sites
PED/PEA-15 (phosphoprotein enriched in diabetes/phosphoprotein enriched in astrocytes) is a ubiquitously expressed protein and a key regulator of cell growth and glucose metabolism. PED/PEA-15 mediates both homotypic and heterotypic interactions and is constituted by an N-terminal canonical death effector domain and a C-terminal tail. In the present study, the backbone dynamics of PED/PEA-15 via (15)N R(1) and R(2) and steady-state [(1)H]-(15)N NOE measurements is reported. The dynamic parameters were analyzed using both Lipari-Szabo model-free formalism and a reduced spectral density mapping approach. The results obtained define a polar and charged surface of the death effector domain characterized by internal motions in the micro- to millisecond timescale, which is crucial for the multiple heterotypic functional protein-protein interactions in which PED/PEA-15 is involved. The present study contributes to a better understanding of the molecular basis of the PED/PEA-15 functional interactions and provides a more detailed surface for the design and development of PED/PEA-15 binders. 2010 The Authors Journal compilation 2010 FEBS.
PED/PEA-15 (phosphoprotein enriched in diabetes/phosphoprotein enriched in astrocytes) is a ubiquitously expressed protein and a key regulator of cell growth and glucose metabolism. PED/PEA-15 mediates both homotypic and heterotypic interactions and is constituted by an N-terminal canonical death effector domain and a C-terminal tail. In the present study, the backbone dynamics of PED/PEA-15 via (15)N R(1) and R(2) and steady-state [(1)H]-(15)N NOE measurements is reported. The dynamic parameters were analyzed using both Lipari-Szabo model-free formalism and a reduced spectral density mapping approach. The results obtained define a polar and charged surface of the death effector domain characterized by internal motions in the micro- to millisecond timescale, which is crucial for the multiple heterotypic functional protein-protein interactions in which PED/PEA-15 is involved. The present study contributes to a better understanding of the molecular basis of the PED/PEA-15 functional interactions and provides a more detailed surface for the design and development of PED/PEA-15 binders. 2010 The Authors Journal compilation 2010 FEBS.
NMR backbone dynamics studies of human PED/PEA-15 outline protein functional sites
NMR backbone dynamics studies of human PED/PEA-15 outline protein functional sites
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* Design, Structural And Biological Characterization Of A Vegf Inhibitor Beta-Hairpin-Constrained Peptide (510 views)
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Impact Factor: 3.447
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Diana D, Smaldone G, De Antonellis P, Pirone L, Carotenuto M, Alonzi A, Di Gaetano S, Zollo M, Pedone E, Fattorusso R
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Impact Factor: 5.696
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Farina B, Doti N, Pirone L, Malgieri G, Pedone E, Ruvo M, Fattorusso R
* Molecular basis of the PED/PEA15 interaction with the C-terminal fragment of phospholipase D1 revealed by NMR spectroscopy (470 views)
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Impact Factor: 3.191
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Attanasio F, Convertino M, Magno A, Caflisch A, Corazza A, Haridas H, Esposito G, Cataldo S, Pignataro B, Milardi D, Rizzarelli E
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Impact Factor: 3.06
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Grasso G, Spoto G
* Plasmonics for the study of metal ion-protein interactions (462 views)
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Impact Factor: 3.578
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Mercurio FA, Marasco D, Pirone L, Scognamiglio PL, Pedone E, Pellecchia M, Leone M
* Heterotypic Sam-Sam Association Between Odin-Sam1 And Arap3-Sam: Binding Affinity And Structural Insights (402 views)
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Impact Factor: 2.92
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Malgieri G, Zaccaro L, Leone M, Bucci E, Esposito S, Baglivo I, Del Gatto A, Russo L, Scandurra R, Pedone PV, Fattorusso R, Isernia C
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Impact Factor: 2.87
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Ruvo M, Sandomenico A, Tudisco L, De Falco S
* Branched peptides for the modulation of protein-protein interactions: More arms are better than one? (531 views)
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Impact Factor: 4.859
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Correale S, Pirone L, Di Marcotullio L, De Smaele E, Greco A, Mazzà D, Moretti M, Alterio V, Vitagliano L, Di Gaetano S, Gulino A, Pedone E
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Impact Factor: 3.022
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Cucinotta V, Giuffrida A, Grasso G, MacCarrone G, Mazzaglia A, Messina M, Vecchio G
* Diaminotrehalose-capped β-cyclodextrin, a new member of hemispherodextrins: Synthesis, thermodynamic and spectroscopic characterization and its exploitation in chiral electrokinetic chromatography (400 views)
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Impact Factor: 2.733
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Verardi R, Traaseth NJ, Shi L, Porcelli F, Monfregola L, De Luca S, Amodeo P, Veglia G, Scaloni A
* Probing membrane topology of the antimicrobial peptide distinctin by solid-state NMR spectroscopy in zwitterionic and charged lipid bilayers (488 views)
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Impact Factor: 3.99
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Diana D, Ziaco B, Scarabelli G, Pedone C, Colombo G, D'Andrea LD, Fattorusso R
* Structural analysis of a helical peptide unfolding pathway (507 views)
Chemistry (ISSN: 1521-3765, 0947-6539, 1521-3765electronic), 2010 May 10; 16(18): 5400-5407.
Impact Factor: 5.476
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Abbate M, Casella G, Fiore T, Grasso G, Pellerito C, Scopelliti M, Spinella A, Pellerito L
* Structural characterization of triorganotin(IV) complexes with sodium fusidate and DFT calculations (379 views)
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Impact Factor: 2.205
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Puglisi A, Rizzarelli E, Vecchio G, Iacovino R, Benedetti E, Pedone C, Saviano M
* Crystal And Molecular Structure Of Beta-Cyclodextrins Functionalized With The Anti-Inflammatory Drug Etodolac (420 views)
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Impact Factor: 2.605
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Sandomenico A, Monti SM, Sabatella M, De Capua A, Tornatore L, Doti N, Viparelli F, Dathan NA, Pedone C, Ruvo M, Marasco D
* Protein-protein interactions: a simple strategy to identify binding sites and peptide antagonists (605 views)
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Impact Factor: 2.473
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Vitagliano L, Ruggiero A, Pedone C, Berisio R
* Molecular dynamics studies of the P pilus rod subunit PapA (572 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 192-199.
Impact Factor: 1.807
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Kaczmarek K, Farina B, Zubrzak P, Jankowski S, Zimecki M, Suder P, Benedetti E, Fattorusso R, Saviano M, Zabrocki J
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Impact Factor: 1.807
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Merlino A, Varriale S, Coscia MR, Mazzarella L, Oreste U
* Structure and dimerization of the teleost transmembrane immunoglobulin region (395 views)
Journal Of Molecular Graphics & Modelling (ISSN: 1093-3263), 2008 Oct; 27(3): 401-407.
Impact Factor: 2.347
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Vitagliano L, Ruggiero A, Pedone C, Berisio R
* Conformational states and association mechanism of Yersinia pestis Caf1 subunits (324 views)
Biochem Biophys Res Commun (ISSN: 0006-291x, 1090-2104, 1090-2104electronic), 2008 Sep 8; 372(4): 804-810.
Impact Factor: 2.648
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Ruvo M, Marasco D, Viparelli F, Tornatore L, Sandomenico A, Doti N, Pedone C, Benedetti E, Monti SM
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Impact Factor: 1.654
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Diana D, Ziaco B, Colombo G, Scarabelli G, Romanelli A, Fedone C, Fattorusso R, D'Andrea LD
* Structural determinants of the unusual helix stability of a de novo engineered vascular endothelial growth factor (VEGF) mimicking peptide (470 views)
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Impact Factor: 5.454
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Malgieri G, Russo L, Esposito S, Baglivo I, Zaccaro L, Pedone EM, Di Blasio B, Isernia C, Pedone PV, Fattorusso R
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Impact Factor: 9.598
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De Pinto V, Tomasello F, Messina A, Guarino F, Benz R, La Mendola D, Magrì A, Milardi D, Pappalardo G
* Determination of the conformation of the human VDAC1 N-terminal peptide, a protein moiety essential for the functional properties of the pore (540 views)
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Impact Factor: 3.446
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Milardi D, Arnesano F, Grasso G, Magrì A, Tabbì G, Scintilla S, Natile G, Rizzarelli E
* Ubiquitin stability and the Lys63-linked polyubiquitination site are compromised on copper binding (378 views)
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Impact Factor: 10.031
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De Capua A, Goodman M, Amino Y, Saviano M, Benedetti E
* Conformation analysis of aspartame-based sweeteners by NMR spectroscopy, molecular dynamics simulations, and X-ray diffraction studies (617 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2006 Feb; 7(2): 377-387.
Impact Factor: 4.1
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D'Andrea LD, Iaccarino G, Fattorusso R, Sorriento D, Carannante C, Capasso D, Trimarco B, Pedone C
* Targeting angiogenesis: Structural characterization and biological properties of a de novo engineered VEGF mimicking peptide (657 views)
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Impact Factor: 10.231
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Falcigno L, Oliva R, D'Auria G, Maletta M, Dettin M, Pasquato A, Di Bello C, Paolillo L
* Structural investigation of the HIV-1 envelope glycoprotein gp160 cleavage site 3: Role of site-specific mutations (434 views)
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Impact Factor: 3.474
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Leone M, Di Lello P, Ohlenschläger O, Pedone E, Bartolucci S, Rossi M, Di Blasio B, Pedone C, Saviano M, Isernia C, Fattorusso R
* Solution structure and backbone dynamics of the K18G/R82E Alicyclobacillus acidocaldarius thioredoxin mutant: A molecular analysis of its reduced thermal stability (574 views)
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Impact Factor: 4.008
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Lombardi A, Nastri F, Marasco D, Maglio O, De Sanctis G, Sinibaldi F, Santucci R, Coletta M, Pavone V
* Design of a new mimochrome with unique topology (534 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2003 Nov 21; 9(22): 5643-5654.
Impact Factor: 4.353
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Oliva R, Falcigno L, D'Auria G, Dettin M, Scarinci C, Pasquato A, Di Bello C, Paolillo L
* Structural investigation of the HIV-1 envelope glycoprotein gp160 cleavage site (376 views)
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Impact Factor: 3.992
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Oliva R, Falcigno L, D'Auria G, Dettin M, Scarinci C, Pasquato A, Di Bello C, Paolillo L
* Structural investigation of the HIV-1 envelope glycoprotein gp160 cleavage site, 2: relevance of an N-terminal helix (360 views)
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Impact Factor: 2.92
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Isernia C, Bucci E, Leone M, Zaccaro L, Di Lello P, Digilio G, Esposito S, Saviano M, Di Blasio B, Pedone C, Pedone PV, Fattorusso R
* NMR structure of the single QALGGH zinc finger domain from the Arabidopsis thaliana SUPERMAN protein (430 views)
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Impact Factor: 3.992
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Saviano G, Rossi F, Benedetti E, Pedone C, Mierke DF, Maione A, Zanotti G, Tancredi T, Saviano M
* Structural consequences of metal complexation of cyclo[Pro-Phe-Phe-Ala-Xaa]2 decapeptides (448 views)
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Impact Factor: 4.614
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Zanotti G, Falcigno L, Saviano M, D'Auria G, Bruno BM, Campanile T, Paolillo L
* Solid state and solution conformation of [Ala7]-phalloidin: A synthetic phallotoxin analogue (492 views)
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Impact Factor: 4.614
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Impellizzeri G, Pappalardo G, Purrello R, Rizzarelli E, Santoro AM
Synthesis, spectroscopic characterisation, and metal ion interaction of a new α-helical peptide (491 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 1998; 4(9): 1791-1798.
Impact Factor: 5.153
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D'Auria G, Maglio O, Nastri F, Lombardi A, Mazzeo M, Morelli G, Paolillo L, Pedone C, Pavone V
Hemoprotein models based on a covalent helix-heme-helix sandwich: 2. Structural characterization of Co(III) mimochrome I Δ and Λ isomers (489 views)
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Impact Factor: 4.828
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* NMR spectroscopy in the conformational analysis of peptides: an overview (91 views)
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Impact Factor: 4.184
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Vincenzi M, Mercurio FA, Leone M
* Protein Interaction Domains: structural features and drug discovery applications (part 2) (80 views)
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Impact Factor: 4.184
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Tornatore L, Capece D, Sandomenico A, Verzella D, Vecchiotti D, Zazzeroni F, Ruvo M, Franzoso G
* The Screening of Combinatorial Peptide Libraries for Targeting Key Molecules or Protein-Protein Interactions in the NF-κB Pathway (9 views)
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Impact Factor: 1.17
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Riccardi C, Capasso D, Coppola A, Platella C, Montesarchio D, Di Gaetano S, Roviello GN, Musumeci D
* Synthesis, Antiproliferative Activity, and DNA Binding Studies of Nucleoamino Acid-Containing Pt(II) Complexes (150 views)
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Impact Factor: 4.421
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Mercurio FA, Di Natale C, Pirone L, Vincenzi M, Marasco D, De Luca S, Pedone EM, Leone M
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Impact Factor: 2.641
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Riccardi C, Capasso D, Rozza GM, Platella C, Montesarchio D, Di Gaetano S, Marzo T, Pratesi A, Messori L, Roviello GN, Musumeci D
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Impact Factor: 3.224
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Vincenzi M, Mercurio FA, Leone M
* Sam Domains in Multiple Diseases (237 views)
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Impact Factor: 3.469
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Farina B, Del Gatto A, Comegna D, Di Gaetano S, Capasso D, Isernia C, Saviano M, Fattorusso R, Zaccaro L, Russo L
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Impact Factor: 1.807
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Grage SL, Kara S, Bordessa A, Doan V, Rizzolo F, Putzu M, Kubar T, Papini AM, Chaume G, Brigaud T, Afonin S, Ulrich AS
* Orthogonal (19) F-Labeling for Solid-State NMR Spectroscopy Reveals the Conformation and Orientation of Short Peptaibols in Membranes (347 views)
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Impact Factor: 5.476
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Di Stasi R, Diana D, Capasso D, Di Gaetano S, De Rosa L, Celentano V, Isernia C, Fattorusso R, D'Andrea LD
* VEGFR Recognition Interface of a Proangiogenic VEGF-Mimetic Peptide Determined In Vitro and in the Presence of Endothelial Cells by NMR Spectroscopy (338 views)
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Impact Factor: 5.16
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Calvanese L, Foca A, Sandomenico A, Foca G, Caporale A, Doti N, Iaccarino E, Leonardi A, D'Auria G, Ruvo M, Falcigno L
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Impact Factor: 2.881
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Cavallari E, Carrera C, Aime S, Reineri F
* (13) C MR Hyperpolarization of Lactate by Using ParaHydrogen and Metabolic Transformation in Vitro (252 views)
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Impact Factor: 5.16
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Lanza V, Travaglia A, Malgieri G, Fattorusso R, GrassoG, Di Natale G, Zito V, Arena G, Milardi D, Rizzarelli E
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Pirone L, Smaldone G, Esposito C, Balasco N, Petoukhov MV, Spilotros A, Svergun DI, Di Gaetano S, Vitagliano L, Pedone E
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Impact Factor: 3.112
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Celentano V, Diana D, Di Salvo C, De Rosa L, Romanelli A, Fattorusso R, D'Andrea LD
* 1, 2, 3-Triazole Bridge as Conformational Constrain in beta-Hairpin Peptides: Analysis of Hydrogen-Bonded Positions (442 views)
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Impact Factor: 5.317
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Farina B, De Paola I, Russo L, Capasso D, Liguoro A, Gatto AD, Saviano M, Pedone PV, Di Gaetano S, Malgieri G, Zaccaro L, Fattorusso R
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Impact Factor: 5.317
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Bottini A, Wu B, Barile E, De SK, Leone M, Pellecchia M
* High-Throughput Screening (HTS) by NMR Guided Identification of Novel Agents Targeting the Protein Docking Domain of YopH (422 views)
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Impact Factor: 2.98
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Smaldone G, Diana D, Pollegioni L, Di Gaetano S, Fattorusso R, Pedone E
* Insight into conformational modification of alpha-synuclein in the presence of neuronal whole cells and of their isolated membranes (436 views)
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Impact Factor: 3.519
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Diana D, Russomanno A, De Rosa L, Di Stasi R, Capasso D, Di Gaetano S, Romanelli A, Russo L, D'Andrea LD, Fattorusso R
* Functional Binding Surface Of A Beta-Hairpin Vegf Receptor Targeting Peptide Determined By Nmr Spectroscopy In Living Cells (445 views)
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Impact Factor: 5.771
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Mercurio FA, Di Natale C, Pirone L, Scognamiglio PL, Marasco D, Pedone EM, Saviano M, Leone M
* Peptide Fragments of Odin-Sam1: Conformational Analysis and Interaction Studies with EphA2-Sam (464 views)
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Impact Factor: 2.85
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Correale S, de Paola I, Morgillo CM, Federico A, Zaccaro L, Pallante P, Galeone A, Fusco A, Pedone E, Luque FJ, Catalanotti B
* Structural Model of the hUbA1-UbcH10 Quaternary Complex: In Silico and Experimental Analysis of the Protein-Protein Interactions between E1, E2 and Ubiquitin (437 views)
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Impact Factor: 3.234
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Vitale RM, Zaccaro L, Di Blasio B, Fattorusso R, Isernia C, Amodeo P, Pedone C, Saviano M
* Conformational features of human melanin-concentrating hormone: an NMR and computational analysis (457 views)
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Impact Factor: 3.088
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Balasco N, Pirone L, Smaldone G, Di Gaetano S, Esposito L, Pedone E, Vitagliano L
* Molecular recognition of Cullin3 by KCTDs: Insights from experimental and computational investigations (370 views)
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Impact Factor: 4.882
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De Rosa L, Diana D, Basile A, Russomanno A, Isernia C, Turco MC, Fattorusso R, D'Andrea LD
* Design, Structural And Biological Characterization Of A Vegf Inhibitor Beta-Hairpin-Constrained Peptide (510 views)
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Impact Factor: 3.447
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Diana D, Smaldone G, De Antonellis P, Pirone L, Carotenuto M, Alonzi A, Di Gaetano S, Zollo M, Pedone E, Fattorusso R
* Mapping Functional Interaction Sites of Human Prune C-Terminal Domain by NMR Spectroscopy in Human Cell Lysates (389 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2013 Sep 9; 19(37): 12217-12220.
Impact Factor: 5.696
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Farina B, Doti N, Pirone L, Malgieri G, Pedone E, Ruvo M, Fattorusso R
* Molecular basis of the PED/PEA15 interaction with the C-terminal fragment of phospholipase D1 revealed by NMR spectroscopy (470 views)
Bba-Gen Subjects (ISSN: 1570-9639, 0006-3002, 0925-4439), 2013 Sep; 1834(8): 1572-1580.
Impact Factor: 3.191
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Attanasio F, Convertino M, Magno A, Caflisch A, Corazza A, Haridas H, Esposito G, Cataldo S, Pignataro B, Milardi D, Rizzarelli E
* Carnosine Inhibits Abeta(42) Aggregation By Perturbing The H-Bond Network In And Around The Central Hydrophobic Cluster (761 views)
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Impact Factor: 3.06
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Grasso G, Spoto G
* Plasmonics for the study of metal ion-protein interactions (462 views)
Anal Bioanal Chem (ISSN: 1618-2642), 2013 Feb; 405(6): 1833-1843.
Impact Factor: 3.578
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Mercurio FA, Marasco D, Pirone L, Scognamiglio PL, Pedone E, Pellecchia M, Leone M
* Heterotypic Sam-Sam Association Between Odin-Sam1 And Arap3-Sam: Binding Affinity And Structural Insights (402 views)
Chembiochem (ISSN: 1439-4227, 1439-9422, 1439-7633), 2013 Jan 2; 14(1): 100-106.
Impact Factor: 2.92
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Malgieri G, Zaccaro L, Leone M, Bucci E, Esposito S, Baglivo I, Del Gatto A, Russo L, Scandurra R, Pedone PV, Fattorusso R, Isernia C
* Zinc to Cadmium Replacement in the A. thaliana SUPERMAN Cys(2)His(2) Zinc Finger Induces Structural Rearrangements of Typical DNA Base Determinant Positions (445 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2011 Nov; 95(11): 801-810.
Impact Factor: 2.87
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Ruvo M, Sandomenico A, Tudisco L, De Falco S
* Branched peptides for the modulation of protein-protein interactions: More arms are better than one? (531 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2011 Jun; 18(16): 2429-2437.
Impact Factor: 4.859
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Correale S, Pirone L, Di Marcotullio L, De Smaele E, Greco A, Mazzà D, Moretti M, Alterio V, Vitagliano L, Di Gaetano S, Gulino A, Pedone E
* Molecular organization of the cullin E3 ligase adaptor KCTD11 (568 views)
Biochimie (ISSN: 0300-9084, 1638-6183, 1638-6183electronic), 2011 Apr; 93(4): 715-724.
Impact Factor: 3.022
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Cucinotta V, Giuffrida A, Grasso G, MacCarrone G, Mazzaglia A, Messina M, Vecchio G
* Diaminotrehalose-capped β-cyclodextrin, a new member of hemispherodextrins: Synthesis, thermodynamic and spectroscopic characterization and its exploitation in chiral electrokinetic chromatography (400 views)
J Sep Sci (ISSN: 1615-9306), 2011 Jan; 34(1): 70-76.
Impact Factor: 2.733
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Verardi R, Traaseth NJ, Shi L, Porcelli F, Monfregola L, De Luca S, Amodeo P, Veglia G, Scaloni A
* Probing membrane topology of the antimicrobial peptide distinctin by solid-state NMR spectroscopy in zwitterionic and charged lipid bilayers (488 views)
Bba-Gen Subjects (ISSN: 0005-2736, 0006-3002, 0925-4439), 2011 Jan; 1808(1): 34-40.
Impact Factor: 3.99
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Diana D, Ziaco B, Scarabelli G, Pedone C, Colombo G, D'Andrea LD, Fattorusso R
* Structural analysis of a helical peptide unfolding pathway (507 views)
Chemistry (ISSN: 1521-3765, 0947-6539, 1521-3765electronic), 2010 May 10; 16(18): 5400-5407.
Impact Factor: 5.476
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Abbate M, Casella G, Fiore T, Grasso G, Pellerito C, Scopelliti M, Spinella A, Pellerito L
* Structural characterization of triorganotin(IV) complexes with sodium fusidate and DFT calculations (379 views)
J Organomet Chem (ISSN: 0022-328x), 2010 May 1; 695(9): 1405-1413.
Impact Factor: 2.205
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Puglisi A, Rizzarelli E, Vecchio G, Iacovino R, Benedetti E, Pedone C, Saviano M
* Crystal And Molecular Structure Of Beta-Cyclodextrins Functionalized With The Anti-Inflammatory Drug Etodolac (420 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2009 Dec; 91(12): 1227-1235.
Impact Factor: 2.605
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Sandomenico A, Monti SM, Sabatella M, De Capua A, Tornatore L, Doti N, Viparelli F, Dathan NA, Pedone C, Ruvo M, Marasco D
* Protein-protein interactions: a simple strategy to identify binding sites and peptide antagonists (605 views)
Chem Biol Drug Des (ISSN: 1747-0285, 1747-0277), 2009 May; 73(5): 483-493.
Impact Factor: 2.473
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Vitagliano L, Ruggiero A, Pedone C, Berisio R
* Molecular dynamics studies of the P pilus rod subunit PapA (572 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 192-199.
Impact Factor: 1.807
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Kaczmarek K, Farina B, Zubrzak P, Jankowski S, Zimecki M, Suder P, Benedetti E, Fattorusso R, Saviano M, Zabrocki J
* Synthesis, conformational analysis and immunological activity of β3Phe-substituted Cyclolinopeptide A analogues (478 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 166-174.
Impact Factor: 1.807
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Merlino A, Varriale S, Coscia MR, Mazzarella L, Oreste U
* Structure and dimerization of the teleost transmembrane immunoglobulin region (395 views)
Journal Of Molecular Graphics & Modelling (ISSN: 1093-3263), 2008 Oct; 27(3): 401-407.
Impact Factor: 2.347
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Vitagliano L, Ruggiero A, Pedone C, Berisio R
* Conformational states and association mechanism of Yersinia pestis Caf1 subunits (324 views)
Biochem Biophys Res Commun (ISSN: 0006-291x, 1090-2104, 1090-2104electronic), 2008 Sep 8; 372(4): 804-810.
Impact Factor: 2.648
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Ruvo M, Marasco D, Viparelli F, Tornatore L, Sandomenico A, Doti N, Pedone C, Benedetti E, Monti SM
* Peptide antagonists of protein-protein interactions identified by screening protein fragments derived by enzyme degradation (349 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2008 Sep; 14(8): N/D-N/D.
Impact Factor: 1.654
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Diana D, Ziaco B, Colombo G, Scarabelli G, Romanelli A, Fedone C, Fattorusso R, D'Andrea LD
* Structural determinants of the unusual helix stability of a de novo engineered vascular endothelial growth factor (VEGF) mimicking peptide (470 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2008; 14(14): 4164-4166.
Impact Factor: 5.454
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Malgieri G, Russo L, Esposito S, Baglivo I, Zaccaro L, Pedone EM, Di Blasio B, Isernia C, Pedone PV, Fattorusso R
* The Prokaryotic Cys2his2 Zinc Finger Domain Adopts A Novel Fold As Revealed By The Solution Structure Of Agrobacterium Tumefaciens Ros Dna Binding Domain (480 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2007 Oct 30; 104(44): 17341-17346.
Impact Factor: 9.598
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De Pinto V, Tomasello F, Messina A, Guarino F, Benz R, La Mendola D, Magrì A, Milardi D, Pappalardo G
* Determination of the conformation of the human VDAC1 N-terminal peptide, a protein moiety essential for the functional properties of the pore (540 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2007 May 7; 8(7): 744-756.
Impact Factor: 3.446
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Milardi D, Arnesano F, Grasso G, Magrì A, Tabbì G, Scintilla S, Natile G, Rizzarelli E
* Ubiquitin stability and the Lys63-linked polyubiquitination site are compromised on copper binding (378 views)
Angew Chem Int Ed (ISSN: 1433-7851, 1521-3773electronic, 1433-7851linking), 2007; 46(42): 7993-7995.
Impact Factor: 10.031
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De Capua A, Goodman M, Amino Y, Saviano M, Benedetti E
* Conformation analysis of aspartame-based sweeteners by NMR spectroscopy, molecular dynamics simulations, and X-ray diffraction studies (617 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2006 Feb; 7(2): 377-387.
Impact Factor: 4.1
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D'Andrea LD, Iaccarino G, Fattorusso R, Sorriento D, Carannante C, Capasso D, Trimarco B, Pedone C
* Targeting angiogenesis: Structural characterization and biological properties of a de novo engineered VEGF mimicking peptide (657 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2005 Oct 4; 102(40): 14215-14220.
Impact Factor: 10.231
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Falcigno L, Oliva R, D'Auria G, Maletta M, Dettin M, Pasquato A, Di Bello C, Paolillo L
* Structural investigation of the HIV-1 envelope glycoprotein gp160 cleavage site 3: Role of site-specific mutations (434 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2004 Dec 3; 5(12): 1653-1661.
Impact Factor: 3.474
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Leone M, Di Lello P, Ohlenschläger O, Pedone E, Bartolucci S, Rossi M, Di Blasio B, Pedone C, Saviano M, Isernia C, Fattorusso R
* Solution structure and backbone dynamics of the K18G/R82E Alicyclobacillus acidocaldarius thioredoxin mutant: A molecular analysis of its reduced thermal stability (574 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2004 May 25; 43(20): 6043-6058.
Impact Factor: 4.008
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Lombardi A, Nastri F, Marasco D, Maglio O, De Sanctis G, Sinibaldi F, Santucci R, Coletta M, Pavone V
* Design of a new mimochrome with unique topology (534 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2003 Nov 21; 9(22): 5643-5654.
Impact Factor: 4.353
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Oliva R, Falcigno L, D'Auria G, Dettin M, Scarinci C, Pasquato A, Di Bello C, Paolillo L
* Structural investigation of the HIV-1 envelope glycoprotein gp160 cleavage site (376 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2003 Sep 4; 4(8): 727-733.
Impact Factor: 3.992
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Oliva R, Falcigno L, D'Auria G, Dettin M, Scarinci C, Pasquato A, Di Bello C, Paolillo L
* Structural investigation of the HIV-1 envelope glycoprotein gp160 cleavage site, 2: relevance of an N-terminal helix (360 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2003 Aug 4; 4(8): 727-733.
Impact Factor: 2.92
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Isernia C, Bucci E, Leone M, Zaccaro L, Di Lello P, Digilio G, Esposito S, Saviano M, Di Blasio B, Pedone C, Pedone PV, Fattorusso R
* NMR structure of the single QALGGH zinc finger domain from the Arabidopsis thaliana SUPERMAN protein (430 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2003 Mar 3; 4(2-3): 171-180.
Impact Factor: 3.992
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Saviano G, Rossi F, Benedetti E, Pedone C, Mierke DF, Maione A, Zanotti G, Tancredi T, Saviano M
* Structural consequences of metal complexation of cyclo[Pro-Phe-Phe-Ala-Xaa]2 decapeptides (448 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2001 Mar 16; 7(6): 1176-1183.
Impact Factor: 4.614
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Zanotti G, Falcigno L, Saviano M, D'Auria G, Bruno BM, Campanile T, Paolillo L
* Solid state and solution conformation of [Ala7]-phalloidin: A synthetic phallotoxin analogue (492 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2001; 7(7): 1479-1485.
Impact Factor: 4.614
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Impellizzeri G, Pappalardo G, Purrello R, Rizzarelli E, Santoro AM
Synthesis, spectroscopic characterisation, and metal ion interaction of a new α-helical peptide (491 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 1998; 4(9): 1791-1798.
Impact Factor: 5.153
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D'Auria G, Maglio O, Nastri F, Lombardi A, Mazzeo M, Morelli G, Paolillo L, Pedone C, Pavone V
Hemoprotein models based on a covalent helix-heme-helix sandwich: 2. Structural characterization of Co(III) mimochrome I Δ and Λ isomers (489 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 1997; 3(3): 350-362.
Impact Factor: 4.828
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59 Records (57 excluding Abstracts).
Total impact factor: 236.36 (231.472 excluding Abstracts).
Total 5 year impact factor: 245.143 (239.659 excluding Abstracts).
Total impact factor: 236.36 (231.472 excluding Abstracts).
Total 5 year impact factor: 245.143 (239.659 excluding Abstracts).
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