Noninvasive quantification of coronary endothelial function by SPECT imaging in children with a history of Kawasaki disease(1204 views) Cicala S, Pellegrino T, Storto G, Caprio MG, Paladini R, Mainolfi C, de Leva F, Cuocolo A
Keywords: Coronary Endothelial Function, Kawasaki Disease, Single Photon Emission Computed Tomography, Methoxy Isobutyl Isonitrile Technetium Tc 99m, Anamnesis, Article, Child, Child Care, Clinical Article, Controlled Study, Coronary Artery Aneurysm, Endothelial Dysfunction, Female, Human, Infant, Long Term Care, Mucocutaneous Lymph Node Syndrome, Non Invasive Procedure, Preschool Child, Single Photon Emission Computer Tomography, Coronary Artery Disease, Coronary Circulation, Coronary Vessels, Vascular, Feasibility Studies, Radiopharmaceuticals, Technetium Tc 99m Sestamibi, Emission-Computed, Single-Photon,
Affiliations: *** IBB - CNR ***
Division of Cardiology, Department of Paediatrics, Santobono-Pausilipon Children Medical Hospital, and Department of Biomorphological and Functional Sciences, Federico II University, Naples, Italy.
SDN Foundation, Institute of Diagnostic and Nuclear Development, Naples, Italy
IRCCS, CROB, Rionero in Vulture, Italy
Institute of Biostructures and Bioimages, National Council of Research, Naples, Italy
References: Not available.
Noninvasive quantification of coronary endothelial function by SPECT imaging in children with a history of Kawasaki disease
PURPOSE: The feasibility of coronary function estimation by single photon emission computed tomography (SPECT) has been recently demonstrated. The aim of this study was to apply SPECT imaging in patients with previous Kawasaki disease (KD) to assess the coronary functional status at long-term follow-up of the acute phase of the disease.; METHODS: Sixteen children with a history of KD underwent 99mTc-sestamibi imaging at rest and during the cold pressor test (CPT). Myocardial blood flow (MBF) was estimated by measuring first transit counts in the pulmonary artery and myocardial counts from SPECT images. Coronary endothelial function was expressed as the ratio of the CPT to rest MBF.; RESULTS: Six KD patients without coronary artery lesions served as controls and ten with coronary artery aneurysms during the acute phase of the disease were separated into two groups: group 1 (n=4) with regressed and group 2 (n=6) with persistent aneurysm at follow-up. The estimated coronary endothelial function was higher in controls compared to patients with coronary artery aneurysms (2.5±0.3 vs 1.7±0.7, p
Noninvasive quantification of coronary endothelial function by SPECT imaging in children with a history of Kawasaki disease
No results.
Noninvasive quantification of coronary endothelial function by SPECT imaging in children with a history of Kawasaki disease
Hesse B, Tagil K, Cuocolo A, Anagnostopoulos C, Bardies M, Bax J, Bengel F, Busemann Sokole E, Davies G, Dondi M, Edenbrandt L, Franken P, Kjaer A, Knuuti J, Lassmann M, Ljungberg M, Marcassa C, Marie PY, Mckiddie F, O'connor M, Prvuolovich E, Underwood R * 3. 0 T perfusion MR imaging(1334 views) Rivista Di Neuroradiologia (ISSN: 1120-9976), 2004; 17(6): 807-812. Impact Factor:0.023 ViewExport to BibTeXExport to EndNote