PET studies of D2-receptor binding in striatal and extrastriatal brain regions: Biochemical support in vivo for separate dopaminergic systems in humans (509 views)
Synapse (ISSN: 0887-4476), 2010 Jun; 64(6): 478-485.
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Paper type: Journal Article,
Impact factor: 2.925, 5-year impact factor: 2.638
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-77952918281&partnerID=40&md5=d9327105687a3b94f0b2251c00c0c7ac
Keywords: Brain, Human, Neurotransmission, Pet, Dopamine 2 Receptor, Isoremoxipride, Raclopride, Adult, Article, Biochemistry, Brain Size, Controlled Study, Corpus Striatum, Dopaminergic System, Female, In Vivo Study, Insula, Nuclear Magnetic Resonance Imaging, Positron Emission Tomography, Priority Journal, Receptor Binding, Rodent, Thalamus, Competitive, Brain Chemistry, Dopamine Antagonists, Middle Aged, Neural Pathways, Positron-Emission Tomography, Pyrrolidines, Salicylamides,
Affiliations:
*** IBB - CNR ***
Department of Clinical Neuroscience, Stockholm Brain Institute, Karolinska Institute, Stockholm, Sweden
School of Computer Science and Communication, Stockholm Brain Institute, Royal Institute of Technology, Stockholm, Sweden
References:
Aalto, S., Bruck, A., Laine, M., Nagren, K., Rinne, J.O., Frontal and temporal dopamine release during working memory and attention tasks in healthy humans: A positron emission tomography study using the high-affinity dopamine D2 receptor ligand [11C]FLB 457 (2005) J Neurosci, 25, pp. 2471-247
Aalto, S., Hirvonen, J., Kaasinen, V., Hagelberg, N., Kajander, J., Nagren, K., Seppala, T., Hietala, J., The effects of d-amphetamine on extrastriatal dopamine D2/D3 receptors: A randomized, double-blind, placebo-controlled PET study with [11C]FLB 457 in healthy subjects (2009) Eur J Nucl Med Mol Imaging, 36, pp. 475-483
Abi-Dargham, A., Mawlawi, O., Lombardo, I., Gil, R., Martinez, D., Huang, Y., Hwang, D.R., Laruelle, M., Prefrontal dopamine D1 receptors and working memory in schizophrenia (2002) J Neurosci, 22, pp. 3708-3719
Abi-Dargham, A., Rodenhiser, J., Printz, D., Zea-Ponce, Y., Gil, R., Kegeles, L.S., Weiss, R., Laruelle, M., Increased baseline occupancy of D2 receptors by dopamine in schizophrenia (2000) Proc Natl Acad Sci USA, 97, pp. 8104-8109
Ahmad, R., Hirani, E., Grasby, P.M., Hume, S.P., Effect of reduction in endogenous dopamine on extrastriatal binding of [11C]FLB 457 in rat brain - An ex vivo study (2006) Synapse, 59, pp. 162-172
Asselin, M.C., Montgomery, A.J., Grasby, P.M., Hume, S.P., Quantification of PET studies with the very high-affinity dopamine D2/D3 receptor ligand [11C]FLB 457: Re-evaluation of the validity of zusing a cerebellar reference region (2006) J Cereb Blood Flow Metab, 27, pp. 378-392
Bose, S.K., Turkheimer, F.E., Howes, O.D., Mehta, M.A., Cunliffe, R., Stokes, P.R., Grasby, P.M., Classification of schizophrenic patients and healthy controls using [18F] fluorodopa PET imaging (2008) Schizophr Res, 106 (2-3), pp. 148-155
Cervenka, S., Palhagen, S.E., Comley, R.A., Panagiotidis, G., Cselenyi, Z., Matthews, J.C., Lai, R.Y., Farde, L., Support for dopaminergic hypoactivity in restless legs syndrome: A PET study on D2-receptor binding (2006) Brain, 129 (PART 8), pp. 2017-2028
Cropley, V.L., Fujita, M., Innis, R.B., Nathan, P.J., Molecular imaging of the dopaminergic system and its association with human cognitive function (2006) Biol Psychiatry, 59, pp. 898-907
Cselenyi, Z., Olsson, H., Farde, L., Gulyas, B., Wavelet-aided parametric mapping of cerebral dopamine D2 receptors using the high affinity PET radioligand [11C]FLB 457 (2002) Neuroimage, 17, pp. 47-60
De La Fuente-Fernandez, R., Ruth, T.J., Sossi, V., Schulzer, M., Calne, D.B., Stoessl, A.J., Expectation and dopamine release: Mechanism of the placebo effect in Parkinson's disease (2001) Science, 293, pp. 1164-1166
Depue, R.A., Luciana, M., Arbisi, P., Collins, P., Leon, A., Dopamine and the structure of personality: Relation of agonist-induced dopamine activity to positive emotionality (1994) J Pers Soc Psychol, 67, pp. 485-498
Farde, L., Ehrin, E., Eriksson, L., Greitz, T., Hall, H., Hedstrom, C.G., Litton, J.E., Sedvall, G., Substituted benzamides as ligands for visualization of dopamine receptor binding in the human brain by positron emission tomography (1985) Proc Natl Acad Sci USA, 82, pp. 3863-3867
Farde, L., Gustavsson, J.P., Jonsson, E., D2 dopamine receptors and personality traits (1997) Nature, 385, p. 590
Farde, L., Hall, H., Ehrin, E., Sedvall, G., Quantitative analysis of D2 dopamine receptor binding in the living human brain by PET (1986) Science, 231, pp. 258-261
Farde, L., Suhara, T., Nyberg, S., Karlsson, P., Nakashima, Y., Hietala, J., Halldin, C., A PET-study of [11C]FLB 457 binding to extrastriatal D2-dopamine receptors in healthy subjects and antipsychotic drug-treated patients (1997) Psychopharmacology, 133, pp. 396-404. , Berl
Garcia-Cabezas, M.A., Rico, B., Sanchez-Gonzalez, M.A., Cavada, C., Distribution of the dopamine innervation in the macaque and human thalamus (2007) Neuroimage, 34, pp. 965-984
Garnett, E.S., Firnau, G., Nahmias, C., Dopamine visualized in the basal ganglia in living man (1983) Nature, 305 (5930), pp. 137-138
Gurevich, E.V., Joyce, J.N., Distribution of dopamine D3 receptor expressing neurons in the human forebrain comparison with D2 receptor expressing neurons (1999) Neuropsychopharmacology, 20 (1), pp. 60-80. , DOI 10.1016/S0893-133X(98)00066-9, PII S0893133X98000669
Hall, H., Farde, L., Halldin, C., Hurd, Y.L., Pauli, S., Sedvall, G., Autoradiographic localization of extrastriatal D2-dopamine receptors in the human brain using [125I]epidepride (1996) Synapse, 23, pp. 115-123
Hall, H., Halldin, C., Dijkstra, D., Wikstrom, H., Wise, L.D., Pugsley, T.A., Sokoloff, P., Sedvall, G., Autoradiographic localisation of D3-dopamine receptors in the human brain using the selective D3-dopamine receptor agonist (+)-[3H]PD 128907 (1996) Psychopharmacology, 128, pp. 240-247. , Berl
Halldin, C., Erixon-Lindroth, N., Pauli, S., Chou, Y.-H., Okubo, Y., Karlsson, P., Lundkvist, C., Farde, L., [11C]PE21: A highly selective radioligand for PET examination of the dopamine transporter in monkey and human brain (2003) European Journal of Nuclear Medicine and Molecular Imaging, 30 (9), pp. 1220-1230. , DOI 10.1007/s00259-003-1212-3
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Hirvonen, J., Aalto, S., Lumme, V., Nagren, K., Kajander, J., Vilkman, H., Hagelberg, N., Hietala, J., Measurement of striatal and thalamic dopamine D2 receptor binding with11C-raclopride (2003) Nuclear Medicine Communications, 24 (12), pp. 1207-1214. , DOI 10.1097/00006231-200312000-00002
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Hultsch, D.F., MacDonald, S.W., Dixon, R.A., Variability in reaction time performance of younger and older adults (2002) J Gerontol B Psychol Sci Soc Sci, 57, pp. P101-P115
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Jönsson, E.G., Nothen, M.M., Grunhage, F., Farde, L., Nakashima, Y., Propping, P., Sedvall, G.C., Polymorphisms in the dopamine D2 receptor gene and their relationships to striatal dopamine receptor density of healthy volunteers (1999) Mol Psychiatry, 4, pp. 290-296
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Roland, P.E., Graufelds, C.J., Wåhlin, J., Ingelman, L., Andersson, M., Ledberg, A., Pedersen, J., Zilles, K., Human brain atlas for high resolution functional and anatomical mapping (1994) Hum Brain Mapp, 1, pp. 173-184
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Asselin, M. C., Montgomery, A. J., Grasby, P. M., Hume, S. P., Quantification of PET studies with the very high-affinity dopamine D2/D3 receptor ligand [11C] FLB 457: Re-evaluation of the validity of zusing a cerebellar reference region (2006) J Cereb Blood Flow Metab, 27, pp. 378-392
Bose, S. K., Turkheimer, F. E., Howes, O. D., Mehta, M. A., Cunliffe, R., Stokes, P. R., Grasby, P. M., Classification of schizophrenic patients and healthy controls using [18F] fluorodopa PET imaging (2008) Schizophr Res, 106 (2-3), pp. 148-155
Cropley, V. L., Fujita, M., Innis, R. B., Nathan, P. J., Molecular imaging of the dopaminergic system and its association with human cognitive function (2006) Biol Psychiatry, 59, pp. 898-907
Depue, R. A., Luciana, M., Arbisi, P., Collins, P., Leon, A., Dopamine and the structure of personality: Relation of agonist-induced dopamine activity to positive emotionality (1994) J Pers Soc Psychol, 67, pp. 485-498
Garcia-Cabezas, M. A., Rico, B., Sanchez-Gonzalez, M. A., Cavada, C., Distribution of the dopamine innervation in the macaque and human thalamus (2007) Neuroimage, 34, pp. 965-984
Garnett, E. S., Firnau, G., Nahmias, C., Dopamine visualized in the basal ganglia in living man (1983) Nature, 305 (5930), pp. 137-138
Gurevich, E. V., Joyce, J. N., Distribution of dopamine D3 receptor expressing neurons in the human forebrain comparison with D2 receptor expressing neurons (1999) Neuropsychopharmacology, 20 (1), pp. 60-80. , DOI 10. 1016/S0893-133X (98) 00066-9, PII S0893133X98000669
Hirvonen, M. M., Lumme, V., Hirvonen, J., Pesonen, U., Nagren, K., Vahlberg, T., Scheinin, H., Hietala, J., C957T polymorphism of the human dopamine D2 receptor gene predicts extrastriatal dopamine receptor availability in vivo (2009) Prog Neuropsychopharmacol Biol Psychiatry, 33, pp. 630-636
Hultsch, D. F., MacDonald, S. W., Dixon, R. A., Variability in reaction time performance of younger and older adults (2002) J Gerontol B Psychol Sci Soc Sci, 57, pp. P101-P115
Innis, R. B., Cunningham, V. J., Delforge, J., Fujita, M., Gjedde, A., Gunn, R. N., Holden, J., Carson, R. E., Consensus nomenclature for in vivo imaging of reversibly binding radioligands (2007) J Cereb Blood Flow Metab, 27, pp. 1533-1539
J nsson, E. G., Nothen, M. M., Grunhage, F., Farde, L., Nakashima, Y., Propping, P., Sedvall, G. C., Polymorphisms in the dopamine D2 receptor gene and their relationships to striatal dopamine receptor density of healthy volunteers (1999) Mol Psychiatry, 4, pp. 290-296
Kessler, R. M., Whetsell, W. O., Ansari, M. S., Votaw, J. R., De Paulis, T., Clanton, J. A., Schmidt, D. E., Manning, R. G., Identification of extrastriatal dopamine D2 receptors in post mortem human brain with [125I] epidepride (1993) Brain Res, 609 (1-2), pp. 237-243
Koepp, M. J., Gunn, R. N., Lawrence, A. D., Cunningham, V. J., Dagher, A., Jones, T., Brooks, D. J., Grasby, P. M., Evidence for striatal dopamine release during a video game (1998) Nature, 393, pp. 266-268
Lammertsma, A. A., Hume, S. P., Simplified reference tissue model for PET receptor studies (1996) Neuroimage, 4 (PART 1), pp. 153-158
Langer, O., N gren, K., Dolle, F., Lundkvist, C., Sandell, J., Swahn, C. G., Vaufrey, F., Halldin, C., Precursor synthesis and radiolabelling of the dopamine D2 receptor ligand [11C] raclopride from [11] methyl triflate (1999) J Labelled Comp Radiopharm, 42, pp. 1183-1193
Maldjian, J. A., Laurienti, P. J., Kraft, R. A., Burdette, J. H., An automated method for neuroanatomic and cytoarchitectonic atlasbased interrogation of fMRI data sets (2003) Neuroimage, 19, pp. 1233-1239
Monchi, O., Ko, J. H., Strafella, A. P., Striatal dopamine release during performance of executive functions: A [(11) C] raclopride PET study (2006) Neuroimage, 33, pp. 907-912
Pruessner, J. C., Li, L. M., Serles, W., Pruessner, M., Collins, D. L., Kabani, N., Lupien, S., Evans, A. C., Volumetry of hippocampus and amygdala with high-resolution MRI and three-dimensional analysis software: Minimizing the discrepancies between laboratories (2000) Cereb Cortex, 10, pp. 433-442
Roland, P. E., Graufelds, C. J., W hlin, J., Ingelman, L., Andersson, M., Ledberg, A., Pedersen, J., Zilles, K., Human brain atlas for high resolution functional and anatomical mapping (1994) Hum Brain Mapp, 1, pp. 173-184
Synapse (ISSN: 0887-4476), 2010 Jun; 64(6): 478-485.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 2.925, 5-year impact factor: 2.638
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-77952918281&partnerID=40&md5=d9327105687a3b94f0b2251c00c0c7ac
Keywords: Brain, Human, Neurotransmission, Pet, Dopamine 2 Receptor, Isoremoxipride, Raclopride, Adult, Article, Biochemistry, Brain Size, Controlled Study, Corpus Striatum, Dopaminergic System, Female, In Vivo Study, Insula, Nuclear Magnetic Resonance Imaging, Positron Emission Tomography, Priority Journal, Receptor Binding, Rodent, Thalamus, Competitive, Brain Chemistry, Dopamine Antagonists, Middle Aged, Neural Pathways, Positron-Emission Tomography, Pyrrolidines, Salicylamides,
Affiliations:
*** IBB - CNR ***
Department of Clinical Neuroscience, Stockholm Brain Institute, Karolinska Institute, Stockholm, Sweden
School of Computer Science and Communication, Stockholm Brain Institute, Royal Institute of Technology, Stockholm, Sweden
References:
Aalto, S., Bruck, A., Laine, M., Nagren, K., Rinne, J.O., Frontal and temporal dopamine release during working memory and attention tasks in healthy humans: A positron emission tomography study using the high-affinity dopamine D2 receptor ligand [11C]FLB 457 (2005) J Neurosci, 25, pp. 2471-247
Aalto, S., Hirvonen, J., Kaasinen, V., Hagelberg, N., Kajander, J., Nagren, K., Seppala, T., Hietala, J., The effects of d-amphetamine on extrastriatal dopamine D2/D3 receptors: A randomized, double-blind, placebo-controlled PET study with [11C]FLB 457 in healthy subjects (2009) Eur J Nucl Med Mol Imaging, 36, pp. 475-483
Abi-Dargham, A., Mawlawi, O., Lombardo, I., Gil, R., Martinez, D., Huang, Y., Hwang, D.R., Laruelle, M., Prefrontal dopamine D1 receptors and working memory in schizophrenia (2002) J Neurosci, 22, pp. 3708-3719
Abi-Dargham, A., Rodenhiser, J., Printz, D., Zea-Ponce, Y., Gil, R., Kegeles, L.S., Weiss, R., Laruelle, M., Increased baseline occupancy of D2 receptors by dopamine in schizophrenia (2000) Proc Natl Acad Sci USA, 97, pp. 8104-8109
Ahmad, R., Hirani, E., Grasby, P.M., Hume, S.P., Effect of reduction in endogenous dopamine on extrastriatal binding of [11C]FLB 457 in rat brain - An ex vivo study (2006) Synapse, 59, pp. 162-172
Asselin, M.C., Montgomery, A.J., Grasby, P.M., Hume, S.P., Quantification of PET studies with the very high-affinity dopamine D2/D3 receptor ligand [11C]FLB 457: Re-evaluation of the validity of zusing a cerebellar reference region (2006) J Cereb Blood Flow Metab, 27, pp. 378-392
Bose, S.K., Turkheimer, F.E., Howes, O.D., Mehta, M.A., Cunliffe, R., Stokes, P.R., Grasby, P.M., Classification of schizophrenic patients and healthy controls using [18F] fluorodopa PET imaging (2008) Schizophr Res, 106 (2-3), pp. 148-155
Cervenka, S., Palhagen, S.E., Comley, R.A., Panagiotidis, G., Cselenyi, Z., Matthews, J.C., Lai, R.Y., Farde, L., Support for dopaminergic hypoactivity in restless legs syndrome: A PET study on D2-receptor binding (2006) Brain, 129 (PART 8), pp. 2017-2028
Cropley, V.L., Fujita, M., Innis, R.B., Nathan, P.J., Molecular imaging of the dopaminergic system and its association with human cognitive function (2006) Biol Psychiatry, 59, pp. 898-907
Cselenyi, Z., Olsson, H., Farde, L., Gulyas, B., Wavelet-aided parametric mapping of cerebral dopamine D2 receptors using the high affinity PET radioligand [11C]FLB 457 (2002) Neuroimage, 17, pp. 47-60
De La Fuente-Fernandez, R., Ruth, T.J., Sossi, V., Schulzer, M., Calne, D.B., Stoessl, A.J., Expectation and dopamine release: Mechanism of the placebo effect in Parkinson's disease (2001) Science, 293, pp. 1164-1166
Depue, R.A., Luciana, M., Arbisi, P., Collins, P., Leon, A., Dopamine and the structure of personality: Relation of agonist-induced dopamine activity to positive emotionality (1994) J Pers Soc Psychol, 67, pp. 485-498
Farde, L., Ehrin, E., Eriksson, L., Greitz, T., Hall, H., Hedstrom, C.G., Litton, J.E., Sedvall, G., Substituted benzamides as ligands for visualization of dopamine receptor binding in the human brain by positron emission tomography (1985) Proc Natl Acad Sci USA, 82, pp. 3863-3867
Farde, L., Gustavsson, J.P., Jonsson, E., D2 dopamine receptors and personality traits (1997) Nature, 385, p. 590
Farde, L., Hall, H., Ehrin, E., Sedvall, G., Quantitative analysis of D2 dopamine receptor binding in the living human brain by PET (1986) Science, 231, pp. 258-261
Farde, L., Suhara, T., Nyberg, S., Karlsson, P., Nakashima, Y., Hietala, J., Halldin, C., A PET-study of [11C]FLB 457 binding to extrastriatal D2-dopamine receptors in healthy subjects and antipsychotic drug-treated patients (1997) Psychopharmacology, 133, pp. 396-404. , Berl
Garcia-Cabezas, M.A., Rico, B., Sanchez-Gonzalez, M.A., Cavada, C., Distribution of the dopamine innervation in the macaque and human thalamus (2007) Neuroimage, 34, pp. 965-984
Garnett, E.S., Firnau, G., Nahmias, C., Dopamine visualized in the basal ganglia in living man (1983) Nature, 305 (5930), pp. 137-138
Gurevich, E.V., Joyce, J.N., Distribution of dopamine D3 receptor expressing neurons in the human forebrain comparison with D2 receptor expressing neurons (1999) Neuropsychopharmacology, 20 (1), pp. 60-80. , DOI 10.1016/S0893-133X(98)00066-9, PII S0893133X98000669
Hall, H., Farde, L., Halldin, C., Hurd, Y.L., Pauli, S., Sedvall, G., Autoradiographic localization of extrastriatal D2-dopamine receptors in the human brain using [125I]epidepride (1996) Synapse, 23, pp. 115-123
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Roland, P. E., Graufelds, C. J., W hlin, J., Ingelman, L., Andersson, M., Ledberg, A., Pedersen, J., Zilles, K., Human brain atlas for high resolution functional and anatomical mapping (1994) Hum Brain Mapp, 1, pp. 173-184
PET studies of D2-receptor binding in striatal and extrastriatal brain regions: Biochemical support in vivo for separate dopaminergic systems in humans
Most molecular imaging studies of the dopamine (DA) system performed to date have focused on the striatum, a region receiving dense dopaminergic innervation. In clinical research on the DA D2-receptor, striatal binding has often been regarded as an index of global DA function, based on the underlying assumption of common regulatory mechanisms for receptor expression across brain regions. Recent data has challenged this view, suggesting differences in genetic regulation between striatal and extrastriatal brain regions. The relationship between binding levels in brain regions has, however, not been directly examined in the same sample. In this study, we searched for interregional correlations between DA D2-receptor availability as determined with Positron Emission Tomography in 16 control subjects. The radioligands [11C]raclopride and [11C]FLB 457 were used for measurements of D2-receptor binding in striatal and extrastriatal regions, respectively. No correlation was observed between D2-receptor availability in striatum and any of the extrastriatal regions, as assessed using both region of interest- and voxel-based analyses. Instead, the pattern of correlations was consistent with the model of separate dopaminergic systems as has been originally observed in rodents. These preliminary results encourage approaches searching for individual patterns of receptor binding across the whole brain volume in clinical studies on the dopamine system. © 2010 Wiley-Liss, Inc.
Most molecular imaging studies of the dopamine (DA) system performed to date have focused on the striatum, a region receiving dense dopaminergic innervation. In clinical research on the DA D2-receptor, striatal binding has often been regarded as an index of global DA function, based on the underlying assumption of common regulatory mechanisms for receptor expression across brain regions. Recent data has challenged this view, suggesting differences in genetic regulation between striatal and extrastriatal brain regions. The relationship between binding levels in brain regions has, however, not been directly examined in the same sample. In this study, we searched for interregional correlations between DA D2-receptor availability as determined with Positron Emission Tomography in 16 control subjects. The radioligands [11C]raclopride and [11C]FLB 457 were used for measurements of D2-receptor binding in striatal and extrastriatal regions, respectively. No correlation was observed between D2-receptor availability in striatum and any of the extrastriatal regions, as assessed using both region of interest- and voxel-based analyses. Instead, the pattern of correlations was consistent with the model of separate dopaminergic systems as has been originally observed in rodents. These preliminary results encourage approaches searching for individual patterns of receptor binding across the whole brain volume in clinical studies on the dopamine system. © 2010 Wiley-Liss, Inc.
PET studies of D2-receptor binding in striatal and extrastriatal brain regions: Biochemical support in vivo for separate dopaminergic systems in humans
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PET studies of D2-receptor binding in striatal and extrastriatal brain regions: Biochemical support in vivo for separate dopaminergic systems in humans
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Cuocolo A, Acampa W, Varrone A, Salvatore M
* Highlights of the Annual Congress of the European Association of Nuclear Medicine, Istanbul, 2005: The incremental value of nuclear medicine for patient management and care (505 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2006 Mar; 33(3): 360-381.
Impact Factor: 4.041
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Granata V, Graziano G, Ruggiero A, Raimo G, Masullo M, Arcari P, Vitagliano L, Zagari A
* Chemical Denaturation Of The Elongation Factor 1 Alpha Isolated From The Hyperthermophilic Archaeon Sulfolobus Solfataricus (327 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2006 Jan 24; 45(3): 719-726.
Impact Factor: 3.633
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Lauria A, Palmiero R, Forni G, Fantacci ME, Imbriaco M, Sodano A, Indovina PL
* A Study On Two Different Cad Systems For Mmammography As An Aid To Radiological Diagnosis In The Search Of Microcalcification Clusters (308 views)
Eur J Radiol (ISSN: 0720-048x), 2005; 55(2): 264-269.
Impact Factor: 1.888
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Leone M, Di Lello P, Ohlenschläger O, Pedone E, Bartolucci S, Rossi M, Di Blasio B, Pedone C, Saviano M, Isernia C, Fattorusso R
* Solution structure and backbone dynamics of the K18G/R82E Alicyclobacillus acidocaldarius thioredoxin mutant: A molecular analysis of its reduced thermal stability (372 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2004 May 25; 43(20): 6043-6058.
Impact Factor: 4.008
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Esposito G, Vitagliano L, Costanzo P, Borrelli L, Barone R, Pavone L, Izzo P, Zagari A, Salvatore F
* Human aldolase A natural mutants: relationship between flexibility of the C-terminal region and enzyme function (339 views)
Biochem J (ISSN: 0264-6021, 1470-8728electronic, 0264-6021linking), 2004 May 15; 380: 51-56.
Impact Factor: 4.278
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Fujita M, Varrone A, Kim KM, Watabe H, Zoghbi SS, Seneca N, Tipre D, Seibyl JP, Innis RB, Iida H
* Effect of scatter correction on the compartmental measurement of striatal and extrastriatal dopamine D2 receptors using [ 123I]epidepride SPET (316 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2004 May; 31(5): 644-654.
Impact Factor: 3.935
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De Simone G, Mandrich L, Menchise V, Giordano V, Febbraio F, Rossi M, Pedone C, Manco G
* A substrate-induced switch in the reaction mechanism of a thermophilic esterase - Kinetic evidences and structural basis (381 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2004 Feb 20; 279(8): 6815-6823.
Impact Factor: 6.355
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Vitagliano L, Ruggiero A, Masullo M, Cantiello P, Arcari P, Zagari A
* The Crystal Structure Of Sulfolobus Solfataricus Elongation Factor 1 Alpha In Complex With Magnesium And Gdp (442 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2004; 43(21): 6630-6636.
Impact Factor: 4.008
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De Simone G, Menchise V, Omaggio S, Pedone C, Scozzafava A, Supuran CT
* Design of weakly basic thrombin inhibitors incorporating novel P1 binding functions: Molecular and X-ray crystallographic studies (332 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2003 Sep 5; 42(30): 9013-9021.
Impact Factor: 3.922
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Pedone E, Bartolucci S, Rossi M, Pierfederici FM, Scire A, Cacciamani T, Tanfani F
* Structural and thermal stability analysis of Escherichia coli and Alicyclobacillus acidocaldarius thioredoxin revealed a molten globule-like state in thermal denaturation pathway of the proteins: an infrared spectroscopic study (519 views)
Biochem J (ISSN: 0264-6021, 1470-8728electronic, 0264-6021linking), 2003 Sep 1; 373: 875-883.
Impact Factor: 4.101
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Borgatti M, Lampronti I, Romanelli A, Pedone C, Saviano M, Bianchi N, Mischiati C, Gambari R
* Transcription factor decoy molecules based on a peptide nucleic acid (PNA)-DNA chimera mimicking Sp1 binding sites (410 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2003 Feb 28; 278(9): 7500-7509.
Impact Factor: 6.482
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Pappata S, Dehaene S, Poline JB, Gregoire MC, Jobert A, Delforge J, Frouin V, Bottlaender M, Dolle F, Di Giamberardino L, Syrota A
* In Vivo detection of striatal dopamine release during reward: A PET study with [11C]raclopride and a single dynamic scan approach (320 views)
Neuroimage (ISSN: 1053-8119, 1053-8119linking), 2002 Sep; 16(4): 1015-1027.
Impact Factor: 5.624
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Masullo M, Cantiello P, Paola B, Fiengo A, Vitagliano L, Zagari A, Arcari P
* Valine114 Replacements In The Archaeal Elongation Factor 1a Enhanced Its Ability To Interact With Aminoacyl-Trna And Kirromycin (339 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2002; 41(49): 14482-14488.
Impact Factor: 4.064
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Delforge J, Bottlaender M, Pappata S, Loc'h C, Syrota A
* Absolute quantification by positron emission tomography of the endogenous ligand (307 views)
J Cereb Blood Flow Metab (ISSN: 0271-678x), 2001 May; 21(5): 613-630.
Impact Factor: 5.477
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Rossi F, Saviano M, Di Talia P, Di Blasio B, Pedone C, Zanotti G, Mosca M, Saviano G, Tancredi T, Ziegler K, Benedetti E
Solution and solid state structure of an aib-containing cyclodecapeptide inhibiting the cholate uptake in hepatocytes (447 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1996; 40(5): 465-478.
Impact Factor: 2.425
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* A structure-based approach for the development of a bicyclic peptide acting as a miniaturized anti-CD55 antibody (24 views) (PDF 7 views)
Int J Biol Macromol (ISSN: 0141-8130linking, 1879-0003electronic), 2021 May 17; 182: 1455-1462.
Impact Factor: 6.95
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Langella E, Buonanno M, Vullo D, Dathan N, Leone M, Supuran C, De Simone G, Monti SM
* Biochemical, biophysical and molecular dynamics studies on the proteoglycan-like domain of carbonic anhydrase IX (299 views)
Cell Mol Life Sci (ISSN: 1420-682xlinking), 2018 Sep; 75(17): 3283-3296.
Impact Factor: 6.721
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Marchitelli R, Aiello M, Cachia A, Quarantelli M, Cavaliere C, Postiglione A, Tedeschi G, Montella P, Milan G, Salvatore M, Salvatore E, Baron JC, Pappata S
* Simultaneous resting-state FDG-PET/fMRI in Alzheimer Disease: Relationship between glucose metabolism and intrinsic activity (597 views)
Neuroimage (ISSN: 1053-8119linking), 2018 Aug 1; 176: 246-258.
Impact Factor: 5.835
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Fusco FA, Fiorentino G, Pedone E, Contursi P, Bartolucci S, Limauro D
* Biochemical characterization of a novel thermostable beta-glucosidase from Dictyoglomus turgidum (643 views)
Int J Biol Macromol (ISSN: 1879-0003electronic, 0141-8130linking), 2018 Jul 1; 113: 783-791.
Impact Factor: 4.784
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Marasco D, Messori L, Marzo T, Merlino A
* Oxaliplatin vs. cisplatin: Competition experiments on their binding to lysozyme (698 views)
Dalton T (ISSN: 1477-9226, 1477-9234, 1477-9226linking), 2015; 44(22): 10392-10398.
Impact Factor: 4.177
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Faiella M, Maglio O, Nastri F, Lombardi A, Lista L, Hagen WR, Pavone V
* De Novo Design, Synthesis and Characterisation of MP3, A New Catalytic Four-Helix Bundle Hemeprotein (435 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2012 Dec 7; 18(50): 15960-15971.
Impact Factor: 5.831
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Castellano I, Merlino A
* γ-glutamyltranspeptidases: Sequence, structure, biochemical properties, and biotechnological applications (392 views)
Cell Mol Life Sci (ISSN: 1420-682x), 2012; 69(20): 3381-3394.
Impact Factor: 5.615
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Esmaeilzadeh M, Farde L, Karlsson P, Varrone A, Halldin C, Waters S, Tedroff J
* Extrastriatal dopamine D 2 receptor binding in Huntington's disease (430 views)
Hum Brain Mapp (ISSN: 1065-9471, 1097-0193electronic, 1065-9471linking), 2011 Oct; 32(10): 1626-1636.
Impact Factor: 5.88
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Nastri F, Lista L, Ringhieri P, Vitale R, Faiella M, Andreozzi C, Travascio P, Maglio O, Lombardi A, Pavone V
* A Heme-Peptide Metalloenzyme Mimetic with Natural Peroxidase-Like Activity (421 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2011 Apr; 17(16): 4444-4453.
Impact Factor: 5.925
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Verardi R, Traaseth NJ, Shi L, Porcelli F, Monfregola L, De Luca S, Amodeo P, Veglia G, Scaloni A
* Probing membrane topology of the antimicrobial peptide distinctin by solid-state NMR spectroscopy in zwitterionic and charged lipid bilayers (469 views)
Bba-Gen Subjects (ISSN: 0005-2736, 0006-3002, 0925-4439), 2011 Jan; 1808(1): 34-40.
Impact Factor: 3.99
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Limauro D, D'Ambrosio K, Langella E, De Simone G, Galdi I, Pedone C, Pedone E, Bartolucci S
* Exploring the catalytic mechanism of the first dimeric Bcp: Functional, structural and docking analyses of Bcp4 from Sulfolobus solfataricus (316 views)
Biochimie (ISSN: 1638-6183, 0300-9084, 1638-6183electronic), 2010 Oct; 92(10): 1435-1444.
Impact Factor: 3.787
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Józsa E, Osz K, Kállay C, de Bona P, Damante CA, Pappalardo G, Rizzarelli E, Sóvágó I
* Nickel(ii) and mixed metal complexes of amyloid-β N-terminus (439 views)
Dalton T (ISSN: 1477-9226, 1477-9234, 1477-9234electronic), 2010 Sep 14; 39(30): 7046-7053.
Impact Factor: 3.647
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D'Andrea LD, Romanelli A, Di Stasi R, Pedone C
* Bioinorganic aspects of angiogenesis (399 views)
Dalton T (ISSN: 1477-9234, 1477-9226, 1477-9234electronic), 2010 Sep 7; 39(33): 7625-7636.
Impact Factor: 3.647
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La Mendola D, Magrì A, Campagna T, Campitiello MA, Raiola L, Isernia C, Hansson O, Bonomo RP, Rizzarelli E
* A doppel alpha-helix peptide fragment mimics the copper(II) interactions with the whole protein (1056 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2010 Jun 1; 16(21): 6212-6223.
Impact Factor: 5.476
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De Simone G, Supuran CT
* Carbonic anhydrase IX: Biochemical and crystallographic characterization of a novel antitumor target (375 views)
Bba-Gen Subjects (ISSN: 1570-9639, 0006-3002, 0925-4439), 2010 Feb; 1804(2): 404-409.
Impact Factor: 2.773
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Darcourt J, Booij J, Tatsch K, Varrone A, Borght TV, Kapucu OL, Nagren K, Nobili F, Walker Z, Van Laere K
* EANM procedure guidelines for brain neurotransmission SPECT using 123I-labelled dopamine transporter ligands, version (688 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2010 Feb; 37(2): 443-450.
Impact Factor: 5.036
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Jozsa E, Hosz K, Kallay C, De Bona P, Damante CA, Pappalardo G, Rizzarelli E, Sovago I
* Nickel (ii) And Mixed Metal Complexes Of Amyloid-B N-Terminus. Results Of Potentiometric And Spectroscopic Studies On The Binary Nickel (ii) And Mixed Metal Nickel (ii)-Copper (ii) And Nickel (ii)-Copper (ii)-Zinc (ii) Complexes Of Peptide Fragments (411 views)
Dalton T (ISSN: 1477-9226, 1477-9234, 1477-9234electronic), 2010; 39(30): 7046-7053.
Impact Factor: 3.647
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Calabrese V, Cornelius C, Rizzarelli E, Owen JB, Dinkova-Kostova AT, Butterfield DA
* Nitric oxide in cell survival: a janus molecule (536 views)
Antioxid Redox Signal (ISSN: 1557-7716, 1523-0864, 1523-0864linking), 2009 Nov; 11(11): 2717-2739.
Impact Factor: 7.581
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Varrone A, Sjoholm N, Eriksson L, Gulyas B, Halldin C, Farde L
* Advancement in PET quantification using 3D-OP-OSEM point spread function reconstruction with the HRRT (412 views) (PDF 256 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2009 Oct; 36(10): 1639-1650.
Impact Factor: 4.531
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Vergote J, Chalon S, Emond P, Vercouillie J, Pappata S, Guilloteau D
* New SPECT and PET dementia tracers (328 views)
Med Nucl (ISSN: 0928-1258), 2009 Mar; 33(3): 137-141.
Impact Factor: 0.155
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Grimaldi P, Ruocco MR, Lanzotti MA, Ruggiero A, Ruggiero I, Arcari P, Vitagliano L, Masullo M
* Characterisation of the components of the thioredoxin system in the archaeon Sulfolobus solfataricus (340 views)
Extremophiles (ISSN: 1431-0651, 1433-4909, 1433-4909electronic), 2008 Jul; 12(4): 553-562.
Impact Factor: 1.782
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Pappata S, Salvatore E, Postiglione A
* In vivo imaging of neurotransmission and brain receptors in dementia (354 views) (PDF 256 views)
J Neuroimaging (ISSN: 1051-2284, 1051-2284linking), 2008 Apr; 18(2): 111-124.
Impact Factor: 1.811
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Prato S, Vitale RM, Contursi P, Lipps G, Saviano M, Rossi M, Bartolucci S
* Molecular modeling and functional characterization of the monomeric primase-polymerase domain from the Sulfolobus solfataricus plasmid pIT3 (383 views)
Febs J (ISSN: 1742-464x), 2008; 275(17): 4389-4402.
Impact Factor: 3.139
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Calabrese V, Mancuso C, Calvani M, Rizzarelli E, Butterfield DA, Stella AM
* Nitric oxide in the central nervous system: neuroprotection versus neurotoxicity (626 views)
Nature Reviews Neuroscience (ISSN: 1471-0048), 2007 Oct; 8(10): 766-775.
Impact Factor: 24.52
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Castiglione F, Rispo A, Cozzolino A, Camera L, D'Argenio G, Tortora R, Grassia R, Bucci C, Ciacci C
* Bowel sonography in adult celiac disease: Diagnostic accuracy and ultrasonographic features (273 views)
Abdom Imaging (ISSN: 0942-8925, 1432-0509), 2007 Feb; 32(1): 73-77.
Impact Factor: 1.213
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Esposito S, Baglivo I, Malgieri G, Russo L, Zaccaro L, D'Andrea LD, Mammucari M, Di Blasio B, Isernia C, Fattorusso R, Pedone PV
* A novel type of zinc finger DNA binding domain in the Agrobacterium tumefaciens transcriptional regulator Ros (449 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2006 Sep 29; 45(34): 10394-10405.
Impact Factor: 3.633
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Cuocolo A, Acampa W, Varrone A, Salvatore M
* Highlights of the Annual Congress of the European Association of Nuclear Medicine, Istanbul, 2005: The incremental value of nuclear medicine for patient management and care (505 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2006 Mar; 33(3): 360-381.
Impact Factor: 4.041
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Granata V, Graziano G, Ruggiero A, Raimo G, Masullo M, Arcari P, Vitagliano L, Zagari A
* Chemical Denaturation Of The Elongation Factor 1 Alpha Isolated From The Hyperthermophilic Archaeon Sulfolobus Solfataricus (327 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2006 Jan 24; 45(3): 719-726.
Impact Factor: 3.633
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Lauria A, Palmiero R, Forni G, Fantacci ME, Imbriaco M, Sodano A, Indovina PL
* A Study On Two Different Cad Systems For Mmammography As An Aid To Radiological Diagnosis In The Search Of Microcalcification Clusters (308 views)
Eur J Radiol (ISSN: 0720-048x), 2005; 55(2): 264-269.
Impact Factor: 1.888
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Leone M, Di Lello P, Ohlenschläger O, Pedone E, Bartolucci S, Rossi M, Di Blasio B, Pedone C, Saviano M, Isernia C, Fattorusso R
* Solution structure and backbone dynamics of the K18G/R82E Alicyclobacillus acidocaldarius thioredoxin mutant: A molecular analysis of its reduced thermal stability (372 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2004 May 25; 43(20): 6043-6058.
Impact Factor: 4.008
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Esposito G, Vitagliano L, Costanzo P, Borrelli L, Barone R, Pavone L, Izzo P, Zagari A, Salvatore F
* Human aldolase A natural mutants: relationship between flexibility of the C-terminal region and enzyme function (339 views)
Biochem J (ISSN: 0264-6021, 1470-8728electronic, 0264-6021linking), 2004 May 15; 380: 51-56.
Impact Factor: 4.278
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Fujita M, Varrone A, Kim KM, Watabe H, Zoghbi SS, Seneca N, Tipre D, Seibyl JP, Innis RB, Iida H
* Effect of scatter correction on the compartmental measurement of striatal and extrastriatal dopamine D2 receptors using [ 123I]epidepride SPET (316 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2004 May; 31(5): 644-654.
Impact Factor: 3.935
View Export to BibTeX Export to EndNote
De Simone G, Mandrich L, Menchise V, Giordano V, Febbraio F, Rossi M, Pedone C, Manco G
* A substrate-induced switch in the reaction mechanism of a thermophilic esterase - Kinetic evidences and structural basis (381 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2004 Feb 20; 279(8): 6815-6823.
Impact Factor: 6.355
View Export to BibTeX Export to EndNote
Vitagliano L, Ruggiero A, Masullo M, Cantiello P, Arcari P, Zagari A
* The Crystal Structure Of Sulfolobus Solfataricus Elongation Factor 1 Alpha In Complex With Magnesium And Gdp (442 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2004; 43(21): 6630-6636.
Impact Factor: 4.008
View Export to BibTeX Export to EndNote
De Simone G, Menchise V, Omaggio S, Pedone C, Scozzafava A, Supuran CT
* Design of weakly basic thrombin inhibitors incorporating novel P1 binding functions: Molecular and X-ray crystallographic studies (332 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2003 Sep 5; 42(30): 9013-9021.
Impact Factor: 3.922
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Pedone E, Bartolucci S, Rossi M, Pierfederici FM, Scire A, Cacciamani T, Tanfani F
* Structural and thermal stability analysis of Escherichia coli and Alicyclobacillus acidocaldarius thioredoxin revealed a molten globule-like state in thermal denaturation pathway of the proteins: an infrared spectroscopic study (519 views)
Biochem J (ISSN: 0264-6021, 1470-8728electronic, 0264-6021linking), 2003 Sep 1; 373: 875-883.
Impact Factor: 4.101
View Export to BibTeX Export to EndNote
Borgatti M, Lampronti I, Romanelli A, Pedone C, Saviano M, Bianchi N, Mischiati C, Gambari R
* Transcription factor decoy molecules based on a peptide nucleic acid (PNA)-DNA chimera mimicking Sp1 binding sites (410 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2003 Feb 28; 278(9): 7500-7509.
Impact Factor: 6.482
View Export to BibTeX Export to EndNote
Pappata S, Dehaene S, Poline JB, Gregoire MC, Jobert A, Delforge J, Frouin V, Bottlaender M, Dolle F, Di Giamberardino L, Syrota A
* In Vivo detection of striatal dopamine release during reward: A PET study with [11C]raclopride and a single dynamic scan approach (320 views)
Neuroimage (ISSN: 1053-8119, 1053-8119linking), 2002 Sep; 16(4): 1015-1027.
Impact Factor: 5.624
View Export to BibTeX Export to EndNote
Masullo M, Cantiello P, Paola B, Fiengo A, Vitagliano L, Zagari A, Arcari P
* Valine114 Replacements In The Archaeal Elongation Factor 1a Enhanced Its Ability To Interact With Aminoacyl-Trna And Kirromycin (339 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2002; 41(49): 14482-14488.
Impact Factor: 4.064
View Export to BibTeX Export to EndNote
Delforge J, Bottlaender M, Pappata S, Loc'h C, Syrota A
* Absolute quantification by positron emission tomography of the endogenous ligand (307 views)
J Cereb Blood Flow Metab (ISSN: 0271-678x), 2001 May; 21(5): 613-630.
Impact Factor: 5.477
View Export to BibTeX Export to EndNote
Rossi F, Saviano M, Di Talia P, Di Blasio B, Pedone C, Zanotti G, Mosca M, Saviano G, Tancredi T, Ziegler K, Benedetti E
Solution and solid state structure of an aib-containing cyclodecapeptide inhibiting the cholate uptake in hepatocytes (447 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1996; 40(5): 465-478.
Impact Factor: 2.425
View Export to BibTeX Export to EndNote
41 Records (41 excluding Abstracts).
Total impact factor: 196.327 (196.327 excluding Abstracts).
Total 5 year impact factor: 195.291 (195.291 excluding Abstracts).
Total impact factor: 196.327 (196.327 excluding Abstracts).
Total 5 year impact factor: 195.291 (195.291 excluding Abstracts).
509 views. Last view on Sunday 11 September 2022, 2:00:58
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