Peptide modified nanocarriers for selective targeting of bombesin receptors (429 views)
Mol Biosyst (ISSN: 1742-206x), 2010 May; 6(5): 878-887.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 3.825, 5-year impact factor: 3.986
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-77952354303&partnerID=40&md5=8899f28893b3ac139aa85c253cf524a1
Keywords: 10 Tetraazacyclododecane 1, 10 Tetraacetic Acid, 10-Tetraazacyclododecane-1, 10-Tetraacetic Acid, Bombesin Receptor, Chelating Agent, Liposome, Peptide, Single Heterocyclic Rings, Article, Chemical Structure, Chemistry, Human, Metabolism, Theoretical Model, Tumor Cell Line, Heterocyclic Compounds, 1-Ring, Molecular Structure,
Affiliations:
*** IBB - CNR ***
Department of Biological Sciences, CIRPeB, University of Naples Federico II and IBB-CNR, Via Mezzocannone 16, 80134 Naples, Italy
Division of Radiological Chemistry, University Hospital Basel, Basel, Switzerland
Department of Chemistry, University of Naples Federico II, Via Cynthia, 80126 Naples, Italy
Forschungszentrum Jülich, Jülich Centre for Neutron Science, LichtenbergerStrasse 1, D-85747 Garching, Germany
Department of Nuclear Medicine, Istituto Nazionale per Lo Studio e la Cura Dei Tumouri, Fondazione G. Pascale, Via M. Semmola, 80131 Naples, Italy
Department of Animal Experimentation, Istituto Nazionale per Lo Studio e la Cura Dei Tumouri, Fondazione G. Pascale, Via M. Semmola, 80131 Naples, Italy
References:
Torchilin, V.P., (2009) Eur. J. Pharm. Biopharm., 71, pp. 431-44
Al-Jamal, W.T., Kostarelos, K., (2007) Nanomedicine (London, UK), 2 (1), pp. 85-98
Ferrari, M., (2005) Nat. Rev. Cancer, 5, pp. 161-17
Allen, T.M., (2002) Nat. Rev. Cancer, 2, pp. 750-763
Mulder, W.J.M., Strijkers, G.J., Briley-Saebo, K.C., Frias, J.C., Aguinado, J.G.S., Vudic, E., Amirbekian, V., Fayad, Z.A., (2007) Magn. Reson. Med., 58, p. 1164
Accardo, A., Tesauro, D., Roscigno, P., Gianolio, E., Paduano, L., D'Errico, G., Pedone, C., Morelli, G., (2004) J. Am. Chem. Soc., 126, pp. 3097-3107
Tesauro, D., Accardo, A., Gianolio, E., Paduano, L., Teixeira, J., Schillen, K., Aime, S., Morelli, G., (2007) ChemBioChem, 8, pp. 950-955
Vaccaro, M., Mangiapia, G., Paduano, L., Gianolio, E., Accardo, A., Tesauro, D., Morelli, G., (2007) ChemPhysChem, 8, pp. 2526-2538
Battey, J.F., Way, J.M., Corjay, M.H., Shapira, H., Kusano, K., Harkins, R., Wu, J.M., Feldman, R.I., (1991) Proc. Natl. Acad. Sci. U. S. A., 88, pp. 395-399
Fathi, Z., Corjay, M.H., Shapira, H., Wada, E., Benya, R., Jensen, R., Viallet, J., Battey, J.F., (1993) J. Biol. Chem., 268, pp. 5979-5984
Nagalla, S.R., Barry, B.J., Creswick, K.C., Eden, P., Taylor, J.T., (1995) Proc. Natl. Acad. Sci. U. S. A., 92, pp. 6205-6209
Wada, E., Way, J., Shapira, H., Kusano, K., Lebacq-Verheyden, A.M., Coy, D., Jensen, R., Battey, J., (1991) Neuron, 6, pp. 421-430
Markwalder, R., Reubi, J.C., (1999) Cancer Res., 59, pp. 1152-1159
Gugger, M., Reubi, J.C., (1999) Am. J. Pathol., 155, pp. 2067-2076
Fleischmann, A., Waser, B., Reubi, J.C., (2007) Cell Oncol., 29, pp. 421-433
Smith, C.J., Volkert, W.A., Hoffman, T.J., (2005) Nucl. Med. Biol., 32, pp. 733-740
Rogers, B.E., Bigott, H.M., McCarthy, D.W., Della Manna, D., Kim, J., Sharp, T.L., Welch, M.J., (2003) Bioconjugate Chem., 14, pp. 756-763
Parry, J.J., Kelly, T.S., Andrews, R., Rogers, B.E., (2007) Bioconjugate Chem., 18, pp. 1110-1117
Al-Nahhas, A., Win, Z., Szyszko, T., Singh, A., Nanni, C., Fanti, S., Rubello, D., (2007) Anticancer Res., 27 (6 B), pp. 4087-4094
Allen, T.M., Hansen, C., Martin, F., Redemann, C., Yau-Young, A., (1991) Biochim. Biophys. Acta, Biomembr., 1066 (1), pp. 29-36
Chang, W.C., White, P.D., (2000) Fmoc Solid Phase Peptide Synthesis, , Oxford Univ Press
Hu, F., Cutler, C.S., Hoffman, T., Sieckman, G., Volkert, W.A., Jurisson, S.S., (2002) Nucl. Med. Biol., 29, pp. 423-430
Reile, H., Armatis, P.E., Schally, A.V., (1994) Prostate (New York, United States), 25, pp. 29-38
Alberts, D.S., Muggia, F.M., Carmichael, J., Winer, E.P., Jahanzeb, M., Venook, A.P., Skubitz, K.M., Gabizon, A.A., (2004) Semin. Oncol., 31, pp. 53-90
Schneider, K., Oltmanns, J., Hassauer, M., (2004) Regul. Toxicol. Pharmacol., 39 (3), pp. 334-347
Vaccaro, M., Accardo, A., Tesauro, D., Mangiapia, G., Löf, D., Schillen, K., Soderman, O., Paduano, L., (2006) Langmuir, 22, pp. 6635-6643
Schmitt, L., Dietrich, C., Tampe, R., (1994) J. Am. Chem. Soc., 116, pp. 8485-8491
Edelhoch, H., (1967) Biochemistry, 6, pp. 1948-1954
Pace, C.N., Vajdos, F., Fee, L., Grimsley, G., Gray, T., (1995) Protein Sci., 4, pp. 2411-2423
Russell, T.P., Lin, J.S., Spooner, S., Wignall, G.D., (1988) J. Appl. Crystallogr., 21 (6), pp. 629-38
Wignall, G.D., Bates, F.S., (1987) J. Appl. Crystallogr., 20 (1), pp. 28-40
Berne, B.J., Pecora, R., (1976) Dynamic Light Scattering with Applications to Chemistry, Biology and Physics, , John Wiley & Sons, New York
Heppeler, A., Froidevaux, S., Maecke, H.R., Jermann, E., Behe, M., Powell, P., Hennig, M., (1999) Chem.-Eur. J., 5, pp. 1974-1981
Zhang, H., Chen, J., Waldherr, C., Hinni, K., Waser, B., Reubi, J.C., Maecke, H.R., (2004) Cancer Res., 64, pp. 6707-15
Torchilin, V. P., (2009) Eur. J. Pharm. Biopharm., 71, pp. 431-44
Al-Jamal, W. T., Kostarelos, K., (2007) Nanomedicine (London, UK), 2 (1), pp. 85-98
Allen, T. M., (2002) Nat. Rev. Cancer, 2, pp. 750-763
Mulder, W. J. M., Strijkers, G. J., Briley-Saebo, K. C., Frias, J. C., Aguinado, J. G. S., Vudic, E., Amirbekian, V., Fayad, Z. A., (2007) Magn. Reson. Med., 58, p. 1164
Battey, J. F., Way, J. M., Corjay, M. H., Shapira, H., Kusano, K., Harkins, R., Wu, J. M., Feldman, R. I., (1991) Proc. Natl. Acad. Sci. U. S. A., 88, pp. 395-399
Nagalla, S. R., Barry, B. J., Creswick, K. C., Eden, P., Taylor, J. T., (1995) Proc. Natl. Acad. Sci. U. S. A., 92, pp. 6205-6209
Smith, C. J., Volkert, W. A., Hoffman, T. J., (2005) Nucl. Med. Biol., 32, pp. 733-740
Rogers, B. E., Bigott, H. M., McCarthy, D. W., Della Manna, D., Kim, J., Sharp, T. L., Welch, M. J., (2003) Bioconjugate Chem., 14, pp. 756-763
Parry, J. J., Kelly, T. S., Andrews, R., Rogers, B. E., (2007) Bioconjugate Chem., 18, pp. 1110-1117
Allen, T. M., Hansen, C., Martin, F., Redemann, C., Yau-Young, A., (1991) Biochim. Biophys. Acta, Biomembr., 1066 (1), pp. 29-36
Chang, W. C., White, P. D., (2000) Fmoc Solid Phase Peptide Synthesis, , Oxford Univ Press
Hu, F., Cutler, C. S., Hoffman, T., Sieckman, G., Volkert, W. A., Jurisson, S. S., (2002) Nucl. Med. Biol., 29, pp. 423-430
Alberts, D. S., Muggia, F. M., Carmichael, J., Winer, E. P., Jahanzeb, M., Venook, A. P., Skubitz, K. M., Gabizon, A. A., (2004) Semin. Oncol., 31, pp. 53-90
Pace, C. N., Vajdos, F., Fee, L., Grimsley, G., Gray, T., (1995) Protein Sci., 4, pp. 2411-2423
Russell, T. P., Lin, J. S., Spooner, S., Wignall, G. D., (1988) J. Appl. Crystallogr., 21 (6), pp. 629-38
Wignall, G. D., Bates, F. S., (1987) J. Appl. Crystallogr., 20 (1), pp. 28-40
Berne, B. J., Pecora, R., (1976) Dynamic Light Scattering with Applications to Chemistry, Biology and Physics, , John Wiley & Sons, New York
Mol Biosyst (ISSN: 1742-206x), 2010 May; 6(5): 878-887.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 3.825, 5-year impact factor: 3.986
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-77952354303&partnerID=40&md5=8899f28893b3ac139aa85c253cf524a1
Keywords: 10 Tetraazacyclododecane 1, 10 Tetraacetic Acid, 10-Tetraazacyclododecane-1, 10-Tetraacetic Acid, Bombesin Receptor, Chelating Agent, Liposome, Peptide, Single Heterocyclic Rings, Article, Chemical Structure, Chemistry, Human, Metabolism, Theoretical Model, Tumor Cell Line, Heterocyclic Compounds, 1-Ring, Molecular Structure,
Affiliations:
*** IBB - CNR ***
Department of Biological Sciences, CIRPeB, University of Naples Federico II and IBB-CNR, Via Mezzocannone 16, 80134 Naples, Italy
Division of Radiological Chemistry, University Hospital Basel, Basel, Switzerland
Department of Chemistry, University of Naples Federico II, Via Cynthia, 80126 Naples, Italy
Forschungszentrum Jülich, Jülich Centre for Neutron Science, LichtenbergerStrasse 1, D-85747 Garching, Germany
Department of Nuclear Medicine, Istituto Nazionale per Lo Studio e la Cura Dei Tumouri, Fondazione G. Pascale, Via M. Semmola, 80131 Naples, Italy
Department of Animal Experimentation, Istituto Nazionale per Lo Studio e la Cura Dei Tumouri, Fondazione G. Pascale, Via M. Semmola, 80131 Naples, Italy
References:
Torchilin, V.P., (2009) Eur. J. Pharm. Biopharm., 71, pp. 431-44
Al-Jamal, W.T., Kostarelos, K., (2007) Nanomedicine (London, UK), 2 (1), pp. 85-98
Ferrari, M., (2005) Nat. Rev. Cancer, 5, pp. 161-17
Allen, T.M., (2002) Nat. Rev. Cancer, 2, pp. 750-763
Mulder, W.J.M., Strijkers, G.J., Briley-Saebo, K.C., Frias, J.C., Aguinado, J.G.S., Vudic, E., Amirbekian, V., Fayad, Z.A., (2007) Magn. Reson. Med., 58, p. 1164
Accardo, A., Tesauro, D., Roscigno, P., Gianolio, E., Paduano, L., D'Errico, G., Pedone, C., Morelli, G., (2004) J. Am. Chem. Soc., 126, pp. 3097-3107
Tesauro, D., Accardo, A., Gianolio, E., Paduano, L., Teixeira, J., Schillen, K., Aime, S., Morelli, G., (2007) ChemBioChem, 8, pp. 950-955
Vaccaro, M., Mangiapia, G., Paduano, L., Gianolio, E., Accardo, A., Tesauro, D., Morelli, G., (2007) ChemPhysChem, 8, pp. 2526-2538
Battey, J.F., Way, J.M., Corjay, M.H., Shapira, H., Kusano, K., Harkins, R., Wu, J.M., Feldman, R.I., (1991) Proc. Natl. Acad. Sci. U. S. A., 88, pp. 395-399
Fathi, Z., Corjay, M.H., Shapira, H., Wada, E., Benya, R., Jensen, R., Viallet, J., Battey, J.F., (1993) J. Biol. Chem., 268, pp. 5979-5984
Nagalla, S.R., Barry, B.J., Creswick, K.C., Eden, P., Taylor, J.T., (1995) Proc. Natl. Acad. Sci. U. S. A., 92, pp. 6205-6209
Wada, E., Way, J., Shapira, H., Kusano, K., Lebacq-Verheyden, A.M., Coy, D., Jensen, R., Battey, J., (1991) Neuron, 6, pp. 421-430
Markwalder, R., Reubi, J.C., (1999) Cancer Res., 59, pp. 1152-1159
Gugger, M., Reubi, J.C., (1999) Am. J. Pathol., 155, pp. 2067-2076
Fleischmann, A., Waser, B., Reubi, J.C., (2007) Cell Oncol., 29, pp. 421-433
Smith, C.J., Volkert, W.A., Hoffman, T.J., (2005) Nucl. Med. Biol., 32, pp. 733-740
Rogers, B.E., Bigott, H.M., McCarthy, D.W., Della Manna, D., Kim, J., Sharp, T.L., Welch, M.J., (2003) Bioconjugate Chem., 14, pp. 756-763
Parry, J.J., Kelly, T.S., Andrews, R., Rogers, B.E., (2007) Bioconjugate Chem., 18, pp. 1110-1117
Al-Nahhas, A., Win, Z., Szyszko, T., Singh, A., Nanni, C., Fanti, S., Rubello, D., (2007) Anticancer Res., 27 (6 B), pp. 4087-4094
Allen, T.M., Hansen, C., Martin, F., Redemann, C., Yau-Young, A., (1991) Biochim. Biophys. Acta, Biomembr., 1066 (1), pp. 29-36
Chang, W.C., White, P.D., (2000) Fmoc Solid Phase Peptide Synthesis, , Oxford Univ Press
Hu, F., Cutler, C.S., Hoffman, T., Sieckman, G., Volkert, W.A., Jurisson, S.S., (2002) Nucl. Med. Biol., 29, pp. 423-430
Reile, H., Armatis, P.E., Schally, A.V., (1994) Prostate (New York, United States), 25, pp. 29-38
Alberts, D.S., Muggia, F.M., Carmichael, J., Winer, E.P., Jahanzeb, M., Venook, A.P., Skubitz, K.M., Gabizon, A.A., (2004) Semin. Oncol., 31, pp. 53-90
Schneider, K., Oltmanns, J., Hassauer, M., (2004) Regul. Toxicol. Pharmacol., 39 (3), pp. 334-347
Vaccaro, M., Accardo, A., Tesauro, D., Mangiapia, G., Löf, D., Schillen, K., Soderman, O., Paduano, L., (2006) Langmuir, 22, pp. 6635-6643
Schmitt, L., Dietrich, C., Tampe, R., (1994) J. Am. Chem. Soc., 116, pp. 8485-8491
Edelhoch, H., (1967) Biochemistry, 6, pp. 1948-1954
Pace, C.N., Vajdos, F., Fee, L., Grimsley, G., Gray, T., (1995) Protein Sci., 4, pp. 2411-2423
Russell, T.P., Lin, J.S., Spooner, S., Wignall, G.D., (1988) J. Appl. Crystallogr., 21 (6), pp. 629-38
Wignall, G.D., Bates, F.S., (1987) J. Appl. Crystallogr., 20 (1), pp. 28-40
Berne, B.J., Pecora, R., (1976) Dynamic Light Scattering with Applications to Chemistry, Biology and Physics, , John Wiley & Sons, New York
Heppeler, A., Froidevaux, S., Maecke, H.R., Jermann, E., Behe, M., Powell, P., Hennig, M., (1999) Chem.-Eur. J., 5, pp. 1974-1981
Zhang, H., Chen, J., Waldherr, C., Hinni, K., Waser, B., Reubi, J.C., Maecke, H.R., (2004) Cancer Res., 64, pp. 6707-15
Torchilin, V. P., (2009) Eur. J. Pharm. Biopharm., 71, pp. 431-44
Al-Jamal, W. T., Kostarelos, K., (2007) Nanomedicine (London, UK), 2 (1), pp. 85-98
Allen, T. M., (2002) Nat. Rev. Cancer, 2, pp. 750-763
Mulder, W. J. M., Strijkers, G. J., Briley-Saebo, K. C., Frias, J. C., Aguinado, J. G. S., Vudic, E., Amirbekian, V., Fayad, Z. A., (2007) Magn. Reson. Med., 58, p. 1164
Battey, J. F., Way, J. M., Corjay, M. H., Shapira, H., Kusano, K., Harkins, R., Wu, J. M., Feldman, R. I., (1991) Proc. Natl. Acad. Sci. U. S. A., 88, pp. 395-399
Nagalla, S. R., Barry, B. J., Creswick, K. C., Eden, P., Taylor, J. T., (1995) Proc. Natl. Acad. Sci. U. S. A., 92, pp. 6205-6209
Smith, C. J., Volkert, W. A., Hoffman, T. J., (2005) Nucl. Med. Biol., 32, pp. 733-740
Rogers, B. E., Bigott, H. M., McCarthy, D. W., Della Manna, D., Kim, J., Sharp, T. L., Welch, M. J., (2003) Bioconjugate Chem., 14, pp. 756-763
Parry, J. J., Kelly, T. S., Andrews, R., Rogers, B. E., (2007) Bioconjugate Chem., 18, pp. 1110-1117
Allen, T. M., Hansen, C., Martin, F., Redemann, C., Yau-Young, A., (1991) Biochim. Biophys. Acta, Biomembr., 1066 (1), pp. 29-36
Chang, W. C., White, P. D., (2000) Fmoc Solid Phase Peptide Synthesis, , Oxford Univ Press
Hu, F., Cutler, C. S., Hoffman, T., Sieckman, G., Volkert, W. A., Jurisson, S. S., (2002) Nucl. Med. Biol., 29, pp. 423-430
Alberts, D. S., Muggia, F. M., Carmichael, J., Winer, E. P., Jahanzeb, M., Venook, A. P., Skubitz, K. M., Gabizon, A. A., (2004) Semin. Oncol., 31, pp. 53-90
Pace, C. N., Vajdos, F., Fee, L., Grimsley, G., Gray, T., (1995) Protein Sci., 4, pp. 2411-2423
Russell, T. P., Lin, J. S., Spooner, S., Wignall, G. D., (1988) J. Appl. Crystallogr., 21 (6), pp. 629-38
Wignall, G. D., Bates, F. S., (1987) J. Appl. Crystallogr., 20 (1), pp. 28-40
Berne, B. J., Pecora, R., (1976) Dynamic Light Scattering with Applications to Chemistry, Biology and Physics, , John Wiley & Sons, New York
Peptide modified nanocarriers for selective targeting of bombesin receptors
The present work describes new supramolecular aggregates obtained by co-assembling two different amphiphilic molecules, one containing the bioactive bombesin peptide (BN), or a scramble sequence, and the other, the DOTA chelating agent, (C18)2DOTA, capable of forming stable complexes with the radioactive 111In(iii) isotope. The peptide in the amphiphilic monomer is spaced by the lipophilic moiety through ethoxylic spacers of different length: a shorter spacer with five units of dioxoethylene moieties in (C18)2L5-peptide, or a longer spacer consisting of a Peg3000 residue in (C18)2Peg3000-peptide. Structural characterization by SANS and DLS techniques indicates that, independently from the presence of the peptide containing monomer in the final composition, the predominant aggregates are liposomes of similar shape and size with a hydrodynamic radius Rh around 200 nm and bilayer thickness, d, of 4 nm. In vitro data show specific binding of the 111In-(C18)2DOTA/(C18)2L5-[7-14] BN 90:10 liposomes in receptor expressing cells. However, the presence of the Peg3000 unit on the external liposomal surface, could hide the peptide and prevent the receptor binding. In vivo experiments using 111In-(C18) 2DOTA/(C18)2L5-[7-14]BN show the expected biological behavior of aggregates of such size and molecular composition, moreover there is an increase in concentration of the GRPR targeting aggregate in the tumors compared to control at the 48 h time point evaluated (2.4% ID/g versus 1.6% ID/g). © 2010 The Royal Society of Chemistry.
The present work describes new supramolecular aggregates obtained by co-assembling two different amphiphilic molecules, one containing the bioactive bombesin peptide (BN), or a scramble sequence, and the other, the DOTA chelating agent, (C18)2DOTA, capable of forming stable complexes with the radioactive 111In(iii) isotope. The peptide in the amphiphilic monomer is spaced by the lipophilic moiety through ethoxylic spacers of different length: a shorter spacer with five units of dioxoethylene moieties in (C18)2L5-peptide, or a longer spacer consisting of a Peg3000 residue in (C18)2Peg3000-peptide. Structural characterization by SANS and DLS techniques indicates that, independently from the presence of the peptide containing monomer in the final composition, the predominant aggregates are liposomes of similar shape and size with a hydrodynamic radius Rh around 200 nm and bilayer thickness, d, of 4 nm. In vitro data show specific binding of the 111In-(C18)2DOTA/(C18)2L5-[7-14] BN 90:10 liposomes in receptor expressing cells. However, the presence of the Peg3000 unit on the external liposomal surface, could hide the peptide and prevent the receptor binding. In vivo experiments using 111In-(C18) 2DOTA/(C18)2L5-[7-14]BN show the expected biological behavior of aggregates of such size and molecular composition, moreover there is an increase in concentration of the GRPR targeting aggregate in the tumors compared to control at the 48 h time point evaluated (2.4% ID/g versus 1.6% ID/g). © 2010 The Royal Society of Chemistry.
Peptide modified nanocarriers for selective targeting of bombesin receptors
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Peptide modified nanocarriers for selective targeting of bombesin receptors
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Impact Factor: 1.807
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Zaccaro L, Del Gatto A, Pedone C, Saviano M
* Peptides for tumour therapy and diagnosis: current status and future directions (1011 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2009 Mar; 16(7): 780-795.
Impact Factor: 4.708
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Pulcrano M, Camera L, Pagano L, Del Vecchio S, Ferone D, Bodei L, Murgia A, Pace L, Storto G, Paganelli G, Colao A, Salvatore M, Lombardi G, Biondi B
* Usefulness of [(111)In-DTPA(0)] octreotide scintigraphy in a family with von Hippel-Lindau disease (359 views)
J Endocrinol Invest (ISSN: 0391-4097, 1720-8386electronic), 2008 Apr; 31(4): 352-359.
Impact Factor: 1.888
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Aloj L, Aurilio M, Rinaldi V, D'Ambrosio L, Tesauro D, Peitl PK, Maina T, Mansi R, Von Guggenberg E, Joosten L, Sosabowski JK, Breeman WA, De Blois E, Koelewijn S, Melis M, Waser B, Beetschen K, Reubi JC, De Jong M
* The EEE project (449 views)
Proc Int Cosm Ray Conf Icrc Universidad Nacional Autonoma De Mexico, 2007; 5(HEPART2): 977-980.
Impact Factor: 0
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Cuocolo A, Acampa W, Varrone A, Salvatore M
* Highlights of the Annual Congress of the European Association of Nuclear Medicine, Istanbul, 2005: The incremental value of nuclear medicine for patient management and care (584 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2006 Mar; 33(3): 360-381.
Impact Factor: 4.041
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* Target selective micelles for bombesin receptors incorporating Au(III)-dithiocarbamato complexes (473 views)
Int J Pharm (ISSN: 0378-5173, 1873-3476), 2014 Oct 1; 473(1-2): 194-202.
Impact Factor: 3.65
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Accardo A, Aloj L, Aurilio M, Morelli G, Tesauro D
* Receptor binding peptides for target-selective delivery of nanoparticles encapsulated drugs (571 views)
Int J Nanomed (ISSN: 1178-2013, 1176-9114, 1176-9114linking), 2014 Mar 27; 9(1): 1537-1557.
Impact Factor: 4.383
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Calce E, Monfregola L, De Luca S
* Synthetic Strategy to Prepare DOTA-Based Bifunctional Chelating Agent Ready to Bind Biomolecular Probes (460 views)
Int J Pept Res Ther (ISSN: 1573-3149, 0929-5666), 2013 Sep; 19(3): 199-202.
Impact Factor: 0.825
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Accardo A, Mansi R, Salzano G, Morisco A, Aurilio M, Parisi A, Maione F, Cicala C, Ziaco B, Tesauro D, Aloj L, De Rosa G, Morelli G
* Bombesin peptide antagonist for target-selective delivery of liposomal doxorubicin on cancer cells (410 views)
Journal Of Drug Targeting (ISSN: 1061-186x), 2012 Nov 21; 21(3): 240-249.
Impact Factor: 2.768
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Accardo A, Salsano G, Morisco A, Aurilio M, Parisi A, Maione F, Cicala C, Tesauro D, Aloj L, De Rosa G, Morelli G
* Peptide-modified liposomes for selective targeting of bombesin receptors overexpressed by cancer cells: A potential theranostic agent (381 views)
Int J Nanomed (ISSN: 1176-9114, 1178-2013, 1178-2013electronic), 2012; 7: 2007-2017.
Impact Factor: 3.463
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Ocak M, Helbok A, Rangger C, Peitl PK, Nock BA, Morelli G, Eek A, Sosabowskijk, Breeman WA, Reubi JC, Decristoforo C
* Comparison of biological stability and metabolism of CCK2 receptor targeting peptides, a collaborative project under COST BM0607 (708 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2011 Sep; 38(8): 1426-1435.
Impact Factor: 4.991
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Accardo A, Morisco A, Gianolio E, Tesauro D, Mangiapia G, Radulescu A, Brandt A, Morelli G
* Nanoparticles containing octreotide peptides and gadolinium complexes for MRI applications (504 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2011 Feb; 17(2): 154-162.
Impact Factor: 1.799
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Nardelli A, Castaldi E, Ortosecco G, Speranza A, Storto G, Pace L, Salvatore M
* Enhancement of reaction conditions for the radiolabelling of DOTA-peptides with high activities of yttrium-90 (468 views)
Applied Radiation And Isotopes (ISSN: 1872-9800, 0969-8043, 0969-8043linking), 2011 Jan; 69(1): 52-55.
Impact Factor: 1.172
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Morisco A, Accardo A, Tesauro D, Palumbo R, Benedetti E, Morelli G
* Peptide-labeled supramolecular aggregates as selective doxorubicin carriers for delivery to tumor cells (360 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2011; 96(1): 88-96.
Impact Factor: 2.87
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Del Vecchio S, Zannetti A, Iommelli F, Lettieri A, Brunetti A, Salvatore M
* Molecular imaging of tumor microenvironment (504 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2010 Jun; 54(3): 243-258.
Impact Factor: 1.724
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Del Vecchio S, Zannetti A, Iommelli F, Lettieri A, Brunetti A, Salvatore M
* Molecular imaging of tumor microenvironment: Challenges and perspectives (596 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2010 Jun; 54(3): 249-258.
Impact Factor: 1.724
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Morisco A, Accardo A, Gianolio E, Tesauro D, Benedetti E, Morelli G
* Micelles derivatized with octreotide as potential target-selective contrast agents in MRI (417 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 242-250.
Impact Factor: 1.807
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Zaccaro L, Del Gatto A, Pedone C, Saviano M
* Peptides for tumour therapy and diagnosis: current status and future directions (1011 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2009 Mar; 16(7): 780-795.
Impact Factor: 4.708
View Export to BibTeX Export to EndNote
Pulcrano M, Camera L, Pagano L, Del Vecchio S, Ferone D, Bodei L, Murgia A, Pace L, Storto G, Paganelli G, Colao A, Salvatore M, Lombardi G, Biondi B
* Usefulness of [(111)In-DTPA(0)] octreotide scintigraphy in a family with von Hippel-Lindau disease (359 views)
J Endocrinol Invest (ISSN: 0391-4097, 1720-8386electronic), 2008 Apr; 31(4): 352-359.
Impact Factor: 1.888
View Export to BibTeX Export to EndNote
Aloj L, Aurilio M, Rinaldi V, D'Ambrosio L, Tesauro D, Peitl PK, Maina T, Mansi R, Von Guggenberg E, Joosten L, Sosabowski JK, Breeman WA, De Blois E, Koelewijn S, Melis M, Waser B, Beetschen K, Reubi JC, De Jong M
* The EEE project (449 views)
Proc Int Cosm Ray Conf Icrc Universidad Nacional Autonoma De Mexico, 2007; 5(HEPART2): 977-980.
Impact Factor: 0
View Export to BibTeX Export to EndNote
Cuocolo A, Acampa W, Varrone A, Salvatore M
* Highlights of the Annual Congress of the European Association of Nuclear Medicine, Istanbul, 2005: The incremental value of nuclear medicine for patient management and care (584 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2006 Mar; 33(3): 360-381.
Impact Factor: 4.041
View Export to BibTeX Export to EndNote
16 Records (16 excluding Abstracts).
Total impact factor: 41.813 (41.813 excluding Abstracts).
Total 5 year impact factor: 45.105 (45.105 excluding Abstracts).
Total impact factor: 41.813 (41.813 excluding Abstracts).
Total 5 year impact factor: 45.105 (45.105 excluding Abstracts).
429 views. Last view on Monday 06 March 2023, 6:33:27
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