Recent advances in structural studies of the carbonic anhydrase family: The crystal structure of human CA IX and CA XIII(471 views) Supuran CT, Di Fiore A, Alterio V, Monti SM, De Simone G
Curr Pharm Des Current Pharmaceutical Design (ISSN: 1381-6128, 1873-4286), 2010; 16(29): 3246-3254.
Keywords: Carbonic Anhydrase Ix, Carbonic Anhydrase Xiii, Crystal Structure, Inhibitor, Structure Based Drug Design, Carbonate Dehydratase, Carbonate Dehydratase Inhibitor, Carbonate Dehydratase Xiii, Isoenzyme, Unclassified Drug, Catalysis, Cytosol, Enzyme Structure, Human, Kinetics, Priority Journal, Protein Expression, Review, X Ray Crystallography, Antigens, Neoplasm, Carbonic Anhydrase Inhibitors, X-Ray, Models, Molecular, Protein Structure, Quaternary,
Affiliations: *** IBB - CNR ***
Università degli Studi di Firenze, Laboratorio di Chimica Bioinorganica, 188, Via della Lastruccia 3, I-50019 Sesto Fiorentino (Firenze), Italy
Istituto di Biostrutture e Bioimmagini-CNR, via Mezzocannone 16, 80134 Naples, Italy
Universit degli Studi di Firenze, Laboratorio di Chimica Bioinorganica, 188, Via della Lastruccia 3, I-50019 Sesto Fiorentino (Firenze), Italy
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Ferry, J. G., The gamma class of carbonic anhydrases (1804) Biochim Biophys Acta, 2010, pp. 374-381
Rowlett, R. S., Structure and catalytic mechanism of the betacarbonic anhydrases (1804) Biochim Biophys Acta, 2010, pp. 362-373
Montgomery, J. C., Venta, P. J., Eddy, R. L., Fukushima, Y. S., Shows, T. B., Tashian, R. E., Characterization of the human gene for a newly discovered carbonic anhydrase, CA VII, and its localization to chromosome 16 (1991) Genomics, 11, pp. 835-848
Lehtonen, J. M., Shen, B., Vihinen, M., Characterization of CA XIII, a novel member of the carbonic anhydrase isozyme family (2004) J Biol Chem, 279, pp. 2719-2792
Whitney, P. L., Briggle, T. V., Membrane-associated carbonic anhydrase purified from bovine lung (1982) J Biol Chem, 257, pp. 12056-12059
Fernley, R. T., Darling, P., Aldred, P., Wright, R. D., Coghlan, J. P., Tissue and species distribution of the secreted carbonic anhydrase isoenzyme (1989) Biochem J, 259, pp. 91-96
Penschow, J. D., Giles, M. E., Coghlan, J. P., Fernley, R. T., Redistribution of carbonic anhydrase VI expression from ducts to acini during development of ovine parotid and submandibular glands (1997) Histochem Cell Biol, 107, pp. 417-422
Supuran, C. T., Scozzafava, A., Casini, A., Carbonic anhydrase inhibitors (2003) Med Res Rev, 23, pp. 146-189
Supuran, C. T., di Fiore, A., de Simone, G., Carbonic anhydrase inhibitors as emerging drugs for the treatment of obesity (2008) Expert Opin Emerg Drugs, 13, pp. 383-392
Andricopulo, A. D., Salum, L. B., Abraham, D. J., Structure-based drug design strategies in medicinal chemistry (2009) Curr Top Med Chem, 9, pp. 771-790
Blundell, T. L., Sibanda, B. L., Montalv o, R. W., Structural biology and bioinformatics in drug design: Opportunities and challenges for target identification and lead discovery (2006) Philos Trans R Soc Lond B Biol Sci, 361, pp. 413-423
Kannan, K. K., Ramanadham, M., Jones, T. A., Structure, refinement, and function of carbonic anhydrase isozymes: Refinement of human carbonic anhydrase I (1984) Ann NY Acad Sci, 429, pp. 49-60
Eriksson, A. E., Jones, T. A., Liljas, A., Refined structure of human carbonic anhydrase II at 2. 0 resolution (1988) Proteins, 4, pp. 274-282
Eriksson, A. E., Liljas, A., Refined structure of bovine carbonic anhydrase III at 2. 0 resolution (1993) Proteins, 16, pp. 29-42
Duda, D. M., Tu, C., Fisher, S. Z., Human carbonic anhydrase III: Structural and kinetic study of catalysis and proton transfer (2005) Biochemistry, 44, pp. 10046-53
Boriack-Sjodin, P. A., Heck, R. W., Laipis, P. J., Silverman, D. N., Christianson, D. W., Structure determination of murine mitochondrial carbonic anhydrase V at 2. 45 resolution: Implications for catalytic proton transfer and inhibitor design (1995) Proc Natl Acad Sci USA, 92, pp. 10949-53
Whittington, D. A., Waheed, A., Ulmasov, B., Crystal structure of the dimeric extracellular domain of human carbonic anhydrase XII, a bitopic membrane protein overexpressed in certain cancer tumor cells (2001) Proc Natl Acad Sci USA, 98, pp. 9545-9555
Domsic, J. F., McKenna, R., Sequestration of carbon dioxide by the hydrophobic pocket of the carbonic anhydrases (1804) Biochim Biophys Acta, 2010, pp. 326-331
Mikulski, R. L., Silverman, D. N., Proton transfer in catalysis and the role of proton shuttles in carbonic anhydrase (1804) Biochim Biophys Acta, 2010, pp. 422-426
Domsic, J. F., Avvaru, B. S., Kim, C. U., Entrapment of carbon dioxide in the active site of carbonic anhydrase II (2008) J Biol Chem, 283, pp. 30766-71
Opavsk, R., Pastorekov, S., Zelnik, V., Human MN/CA9 gene, a novel member of the carbonic anhydrase family: Structure and exon to protein domain relationships (1996) Genomics, 33, pp. 480-487
Pastorekov, S., Barathova, M., Kopacek, J., Pastorek, J., Carbonic anhydrase inhibitors targeting cancer: Therapeutic, immunologic, and diagnostic tools targeting isoforms IX and XI (2009) Drug Design of Zinc-enzyme Inhibitors. Hoboken, pp. 193-222. , In: Supuran CT, Winum JY, Eds., New Jersey: Wiley
Pastorekov, S., Pastorek, J., Cancer-related carbonic anhydrase isozymes and their inhibition (2004) Carbonic Anhydrase: Its Inhibitors and Activators, pp. 255-281. , In: Supuran CT, Scozzafava A, Conway J, Eds., Boca Raton, FL: CRC Press
Kaluz, S., Kaluzov, M., Liao, S. Y., Lerman, M., Stanbridge, E. J., Transcriptional control of the tumor- and hypoxia-marker carbonic anhydrase 9: A one transcription factor (HIF-1) show? (2009) Biochim Biophys Acta, 1795, pp. 162-172
Wykoff, C. C., Beasley, N. J., Watson, P. H., Hypoxia-inducible expression of tumor-associated carbonic anhydrases (2000) Cancer Res, 60, pp. 7075-7058
Harris, A. L., Hypoxia--a key regulatory factor in tumour growth (2002) Nat Rev Cancer, 2, pp. 38-47
Semenza, G. L., Targeting HIF-1 for cancer therapy (2003) Nat Rev Cancer, 3, pp. 721-732
Gut, M. O., Parkkila, S., Vernerov, Z., Gastric hyperplasia in mice with targeted disruption of the carbonic anhydrase gene Car9 (2002) Gastroenterology, 123, pp. 1889-1903
Brahimi-Horn, M. C., Pouyss gur, J., Hypoxia in cancer cell metabolism and pH regulation (2007) Essays Biochem, 43, pp. 165-178
vastov, E., Hul kov, A., Rafajov, M., Hypoxia activates the capacity of tumor-associated carbonic anhydrase IX to acidify extracellular pH (2004) FEBS Lett, 577, pp. 439-445
Z vada, J., Z vadov, Z., Pastorek, J., Biesov, Z., Jezek, J., Velek, J., Human tumour-associated cell adhesion protein MN/CA IX: Identification of M75 epitope and of the region mediating cell adhesion (2000) Br J Cancer, 82, pp. 1808-1881
Svastov, E., Zilka, N., Zat'Ovicov, M., Carbonic anhydrase IX reduces E-cadherin-mediated adhesion of MDCK cells via interaction with beta-catenin (2003) Exp Cell Res, 290, pp. 332-345
Beavon, I. R., Regulation of E-cadherin: Does hypoxia initiate the metastatic cascade? (1999) Mol Pathol, 52, pp. 179-188
Supuran, C. T., Manole, G., Dinculescu, A., Carbonic anhydrase inhibitors. V: Pyrylium salts in the synthesis of isozyme-specific inhibitors (1992) J Pharm Sci, 81, pp. 716-719
Casey, J. R., Morgan, P. E., Vullo, D., Scozzafava, A., Mastrolorenzo, A., Supuran, C. T., Carbonic anhydrase inhibitors. Design of selective, membrane-impermeant inhibitors targeting the human tumorassociated isozyme IX (2004) J Med Chem, 47, pp. 2337-2374
Recent advances in structural studies of the carbonic anhydrase family: The crystal structure of human CA IX and CA XIII