Weekly Chemotherapy with Cisplatin and Paclitaxel and Concurrent Radiation Therapy as Preoperative Treatment in Locally Advanced Esophageal Cancer: A Phase II Study
Weekly Chemotherapy with Cisplatin and Paclitaxel and Concurrent Radiation Therapy as Preoperative Treatment in Locally Advanced Esophageal Cancer: A Phase II Study(347 views) Orditura M, Galizia G, Napolitano V, Martinelli E, Pacelli R, Lieto E, Aurilio G, Vecchione L, Morgillo F, Catalano G, Ciardiello F, Del Genio A, Di Martino N, De Vita F
Cancer Investigation (ISSN: 0735-7907), 2010 Oct; 28(8): 820-827.
Division of Medical Oncology, School of Medicine, Second University of Naples, Naples, Italy
Department of Clinical and Experimental Medicine and Surgery F. Magrassi e A. Lanzara, School of Medicine, Second University of Naples, Naples, Italy
Division of Radiotherapy, Federico II University of Naples, School of Medicine, Naples, Italy
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Urschel, J. D., Vasan, H., A meta-analysis of randomized controlled trials that compared neoadjuvant chemoradiation and surgery to surgery alone for resectable esophageal cancer (2003) Am J Surg, 185, pp. 538-543
Meluch, A. A., Greco, F. A., Gray, J. R., Thomas, M., Sutton, V. M., Davis, J. L., Kalman, L. A., Rinaldi, D. A., Hainsworth, Preoperative therapy with concurrent paclitaxel/ carboplatin/infusional 5-FU and radiation therapy in locoregional esophageal cancer: Final results of a Minnie Pearl Cancer Research Network phase II trial (2003) Cancer J, 9, pp. 251-260
Henry, L. R., Goldberg, M., Scott, W., Konski, A., Meropol, N., Freedman, G., Weiner, L. M., Cheng, J. D., Induction cisplatin and paclitaxel followed by combination chemoradiotherapy with 5-fluorouracil, cisplatin, and paclitaxel before resection in localized esophageal cancer: A phase II report (2006) Ann Surg Oncol, 13, pp. 214-220
Roof, K. S., Coen, J., Lynch, T. J., Wright, C., Fidias, P., Willett, C. G., Choi, N. C., Concurrent cisplatin, 5-FU, paclitaxel, and radiation therapy in patients with locally advanced esophageal cancer (2006) Int J Radiat Oncol Biol Phys, 65, pp. 1120-1128
Lowy, A. M., Firdaus, I., Roychowdhury, D., Redmond, K., Howington, J. A., Sussman, J. J., Safa, M., Jazieh, A. R., A phase II study of sequential neoadjuvant gemcitabine and paclitaxel, radiation therapy with cisplatin and 5-fluorouracil and surgery in locally advanced esophageal carcinoma (2006) Am J Clin Oncol, 6, pp. 551-561
Blanke, C. D., Choy, H., Teng, M., Beauchamp, R. D., Leach, S., Roberts, J., Washington, K., Johnson, D. H., Concurrent paclitaxel and thoracic irradiation for locally advanced esophageal cancer (1999) Seminars in Radiation Oncology, 9 (2 SUPPL. 1), pp. 43-52
Urba, S. G., Orringer, M. B., Turrisi, A., Iannettoni, M., Forastiere, A., Strawderman, M., A phase II trial of preoperative cisplatin, paclitaxel, and radiation therapy before trans-hiatal esophagectomy in patients with locoregional esophageal cancer (2001) J Clin Oncol, 19, p. 248
Adelstein, D. J., Rice, T. W., Rybicki, L. A., Larto, M. A., Ciezki, J., Saxton, J., Decamp, M., Zuccaro, G., Does paclitaxel improve chemoradiotherapy of locoregionally advanced esophageal cancer? A nonrandomized comparison with fluorouracil-based therapy (2000) J Clin Oncol, 18, pp. 2032-2039
Jamil, L. H., Gill, K. R., Staging, B. W. M., And restaging of advanced esophageal cancer (2008) Curr Opin Gastroenterol, 24 (4), pp. 530-534
Schneider, P. M., Metzger, R., Schaefer, H., Baumgarten, F., Vallbohmer, D., Brabender, J., Wolfgarten, E., Hoelscher, A. H., Response evaluation by endoscopy, rebiopsy, and endoscopic ultrasound does not accurately predict histopathologic regression after neoadjuvant chemoradiation for esophageal cancer (2008) Ann Surg, 248 (6), pp. 902-908
Omloo, J. M., Sloof, G. W., Boellaard, R., Hoekstra, O. S., Jager, P. L., Van Dullemen, H. M., Fockens, P., Van Lanschot, J. J., Importance of fluorodeoxyglucose-positron emission tomography (FDG-PET) and endoscopic ultrasonography parameters in predicting survival following surgery for esophageal cancer (2008) Endoscopy, 40 (6), pp. 464-471
Ajani, J. A., Ilson, D. H., Daugherty, K., Pazdur, R., Lynch, P. M., Kelsen, D. P., Activity of taxol in patients with squamous cell carcinoma and adenocarcinoma of the esophagus (1994) J Natl Cancer Inst, 86, pp. 1086-1091
Rowinsky, E. K., Donehover, R. C., Paclitaxel (Taxol) (1995) N Eng J Med, 332, pp. 1004-1013
Kim, D. W., Blanke, C. D., Wu, H., Shyr, Y., Berlin, J., Beauchamp, R. D., Chakravarthy, B., Phase II study of preoperative paclitaxel/ cisplatin with radiotherapy in locally advanced esophageal cancer (2007) Int J Radiat Oncol Biol Phys, 67, pp. 397-404
Lin, C. C., Hsu, C. H., Cheng, J. C., Wang, H. P., Lee, J. M., Yeh, K. H., Yang, C. H., Lee, Y. C., Concurrent chemoradiotherapy with twice weekly paclitaxel and cisplatin followed by esophagectomy for locally advanced esophageal cancer (2007) Ann Oncol, 18, pp. 93-98
Mandard, A. M., Dalibard, F., Mandard, J. C., Marnay, J., Henry-Amar, M., Petiot, J. F., Roussel, A., Samama, G., Pathologic assessment of tumor regression after preoperative chemoradiotherapy of esophageal cancer (1994) Cancer, 73, pp. 2680-2686
Dam, H. Q., Manzone, T. M., Sagar, W., Evolving role of 18Ffluorodeoxyglucose positron emission tomography in the management of esophageal carcinoma (2006) Surg Oncol Clin N Am, 15, pp. 733-749
Erasmus, J. J., Munden, R. F., The role of integrated computed tomography positron-emission tomography in esophageal cancer: Staging and assessment of therapeutic response (2007) Semin Radiat Oncol, 17, pp. 29-37
Weekly Chemotherapy with Cisplatin and Paclitaxel and Concurrent Radiation Therapy as Preoperative Treatment in Locally Advanced Esophageal Cancer: A Phase II Study
We evaluated the association of a weekly cisplatin (35 mg/mq) and paclitaxel (45 mg/mq) regimen with radiotherapy (46 Gy) as primary treatment in locally advanced esophageal cancer (LAEC). The main end point was the activity in terms of pathologic complete response (pathCR) rate. Thirty-three LAEC patients received chemoradiation therapy during weeks 1-6 followed by esophagectomy. A pathCR was observed in 10/33 patients; 20/33 and 3/33 patients showed PR and SD, respectively. The EUS maximal transverse cross sectional area reduction >50% significantly correlated with pathCR. Three-year survival rate was 35%. These results support the activity and mild toxicity of this regimen.
Weekly Chemotherapy with Cisplatin and Paclitaxel and Concurrent Radiation Therapy as Preoperative Treatment in Locally Advanced Esophageal Cancer: A Phase II Study
No results.
Weekly Chemotherapy with Cisplatin and Paclitaxel and Concurrent Radiation Therapy as Preoperative Treatment in Locally Advanced Esophageal Cancer: A Phase II Study