Weekly Chemotherapy with Cisplatin and Paclitaxel and Concurrent Radiation Therapy as Preoperative Treatment in Locally Advanced Esophageal Cancer: A Phase II Study (612 views)
Cancer Investigation (ISSN: 0735-7907), 2010 Oct; 28(8): 820-827.
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Paper type: Journal Article,
Impact factor: 2.39, 5-year impact factor: 2.22
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-77956636233&partnerID=40&md5=cfaa920f72e7c2bcbd7a5c4ce85c1f61
Keywords: Cisplatin, Esophageal Cancer, Paclitaxel, Preoperative Chemoradiotherapy, Adult, Advanced Cancer, Alopecia, Article, Bronchoscopy, Cancer Combination Chemotherapy, Clinical Article, Clinical Trial, Computer Assisted Tomography, Diarrhea, Esophagitis, Esophagus Cancer, Esophagus Resection, Female, Granulocytopenia, Heart Atrium Fibrillation, Human, Nausea, Neuropathy, Phase 2 Clinical Trial, Positron Emission Tomography, Preoperative Treatment, Priority Journal, Survival Rate, Treatment Outcome, Adenocarcinoma, Antineoplastic Combined Chemotherapy Protocols, Biopsy, Squamous Cell, Combined Modality Therapy, Drug Administration Schedule, Esophageal Neoplasms, Esophagectomy, Middle Aged, Neoplasm Staging, Patient Selection, Platelet Count, Prognosis, Time Factors,
Affiliations:
*** IBB - CNR ***
Division of Medical Oncology, School of Medicine, Second University of Naples, Naples, Italy
Department of Clinical and Experimental Medicine and Surgery F. Magrassi e A. Lanzara, School of Medicine, Second University of Naples, Naples, Italy
Division of Radiotherapy, Federico II University of Naples, School of Medicine, Naples, Italy
References:
Not available.
Cancer Investigation (ISSN: 0735-7907), 2010 Oct; 28(8): 820-827.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 2.39, 5-year impact factor: 2.22
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-77956636233&partnerID=40&md5=cfaa920f72e7c2bcbd7a5c4ce85c1f61
Keywords: Cisplatin, Esophageal Cancer, Paclitaxel, Preoperative Chemoradiotherapy, Adult, Advanced Cancer, Alopecia, Article, Bronchoscopy, Cancer Combination Chemotherapy, Clinical Article, Clinical Trial, Computer Assisted Tomography, Diarrhea, Esophagitis, Esophagus Cancer, Esophagus Resection, Female, Granulocytopenia, Heart Atrium Fibrillation, Human, Nausea, Neuropathy, Phase 2 Clinical Trial, Positron Emission Tomography, Preoperative Treatment, Priority Journal, Survival Rate, Treatment Outcome, Adenocarcinoma, Antineoplastic Combined Chemotherapy Protocols, Biopsy, Squamous Cell, Combined Modality Therapy, Drug Administration Schedule, Esophageal Neoplasms, Esophagectomy, Middle Aged, Neoplasm Staging, Patient Selection, Platelet Count, Prognosis, Time Factors,
Affiliations:
*** IBB - CNR ***
Division of Medical Oncology, School of Medicine, Second University of Naples, Naples, Italy
Department of Clinical and Experimental Medicine and Surgery F. Magrassi e A. Lanzara, School of Medicine, Second University of Naples, Naples, Italy
Division of Radiotherapy, Federico II University of Naples, School of Medicine, Naples, Italy
References:
Not available.
Weekly Chemotherapy with Cisplatin and Paclitaxel and Concurrent Radiation Therapy as Preoperative Treatment in Locally Advanced Esophageal Cancer: A Phase II Study
We evaluated the association of a weekly cisplatin (35 mg/mq) and paclitaxel (45 mg/mq) regimen with radiotherapy (46 Gy) as primary treatment in locally advanced esophageal cancer (LAEC). The main end point was the activity in terms of pathologic complete response (pathCR) rate. Thirty-three LAEC patients received chemoradiation therapy during weeks 1-6 followed by esophagectomy. A pathCR was observed in 10/33 patients; 20/33 and 3/33 patients showed PR and SD, respectively. The EUS maximal transverse cross sectional area reduction >50% significantly correlated with pathCR. Three-year survival rate was 35%. These results support the activity and mild toxicity of this regimen.
We evaluated the association of a weekly cisplatin (35 mg/mq) and paclitaxel (45 mg/mq) regimen with radiotherapy (46 Gy) as primary treatment in locally advanced esophageal cancer (LAEC). The main end point was the activity in terms of pathologic complete response (pathCR) rate. Thirty-three LAEC patients received chemoradiation therapy during weeks 1-6 followed by esophagectomy. A pathCR was observed in 10/33 patients; 20/33 and 3/33 patients showed PR and SD, respectively. The EUS maximal transverse cross sectional area reduction >50% significantly correlated with pathCR. Three-year survival rate was 35%. These results support the activity and mild toxicity of this regimen.
Weekly Chemotherapy with Cisplatin and Paclitaxel and Concurrent Radiation Therapy as Preoperative Treatment in Locally Advanced Esophageal Cancer: A Phase II Study
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Weekly Chemotherapy with Cisplatin and Paclitaxel and Concurrent Radiation Therapy as Preoperative Treatment in Locally Advanced Esophageal Cancer: A Phase II Study
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15 Records (15 excluding Abstracts).
Total impact factor: 41.905 (41.905 excluding Abstracts).
Total 5 year impact factor: 41.118 (41.118 excluding Abstracts).
Total impact factor: 41.905 (41.905 excluding Abstracts).
Total 5 year impact factor: 41.118 (41.118 excluding Abstracts).
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