A point mutation (G574A) in the chemokine receptor CXCR4 detected in human cancer cells enhances migration (446 views)
Cell Cycle (ISSN: 1538-4101), 2009 Apr 15; 8(8): 1228-1237.
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Paper type: Journal Article,
Impact factor: 4.087, 5-year impact factor: 3.693
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-65949095206&partnerID=40&md5=546e5dfcb59cdca197df3886437d652b
Keywords: Amd3100, Chemokine Receptor, Chemotactic Factor, Chemotaxis, Colon Cancer, Cxc Chemokine Receptor, Cxcl12, G-Protein Coupled Receptor (gpcr), Gi Subfamily, Melanoma, Perk, Chemokine Receptor Cxcr4, Mitogen Activated Protein Kinase 1, Plerixafor, Stromal Cell Derived Factor 1, Animal Experiment, Article, Cancer Cell Culture, Carcinoma Cell, Cell Growth, Cell Migration, Colon Carcinoma, Female, Gene Expression, Gene Function, Genetic Transfection, Human, Human Cell, Human Cell Culture, In Vitro Study, In Vivo Study, Melanoma Cell, Mouse, Mutant, Nonhuman, Point Mutation, Protein Phosphorylation, Squamous Cell Carcinoma, Tumor Growth, Wild Type, Alanine, Amino Acid Sequence, Amino Acid Substitution, Cell Line, Cell Movement, Cell Proliferation, Chemokine Cxcl12, Glycine, Molecular Sequence Data, Mutant Proteins, Neoplasms,
Affiliations:
*** IBB - CNR ***
Clinical Immunology, G. Pascale National Cancer Institute, Fondazione G. Pascale, Naples, Italy
Animal Facility, G. Pascale National Cancer Institute, Fondazione G. Pascale, Naples, Italy
Pathology, G. Pascale National Cancer Institute, Fondazione G. Pascale, Naples, Italy
Istituto di Chimica Biomolecolare, Consiglio Nazionale Ricerche, Traversa La Crucca, Italy
Istituto di Biostrutture e Bioimmagini (IBB), Consiglio Nazionale Ricerche, Naples, Italy
References:
Not available.
Cell Cycle (ISSN: 1538-4101), 2009 Apr 15; 8(8): 1228-1237.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 4.087, 5-year impact factor: 3.693
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-65949095206&partnerID=40&md5=546e5dfcb59cdca197df3886437d652b
Keywords: Amd3100, Chemokine Receptor, Chemotactic Factor, Chemotaxis, Colon Cancer, Cxc Chemokine Receptor, Cxcl12, G-Protein Coupled Receptor (gpcr), Gi Subfamily, Melanoma, Perk, Chemokine Receptor Cxcr4, Mitogen Activated Protein Kinase 1, Plerixafor, Stromal Cell Derived Factor 1, Animal Experiment, Article, Cancer Cell Culture, Carcinoma Cell, Cell Growth, Cell Migration, Colon Carcinoma, Female, Gene Expression, Gene Function, Genetic Transfection, Human, Human Cell, Human Cell Culture, In Vitro Study, In Vivo Study, Melanoma Cell, Mouse, Mutant, Nonhuman, Point Mutation, Protein Phosphorylation, Squamous Cell Carcinoma, Tumor Growth, Wild Type, Alanine, Amino Acid Sequence, Amino Acid Substitution, Cell Line, Cell Movement, Cell Proliferation, Chemokine Cxcl12, Glycine, Molecular Sequence Data, Mutant Proteins, Neoplasms,
Affiliations:
*** IBB - CNR ***
Clinical Immunology, G. Pascale National Cancer Institute, Fondazione G. Pascale, Naples, Italy
Animal Facility, G. Pascale National Cancer Institute, Fondazione G. Pascale, Naples, Italy
Pathology, G. Pascale National Cancer Institute, Fondazione G. Pascale, Naples, Italy
Istituto di Chimica Biomolecolare, Consiglio Nazionale Ricerche, Traversa La Crucca, Italy
Istituto di Biostrutture e Bioimmagini (IBB), Consiglio Nazionale Ricerche, Naples, Italy
References:
Not available.
A point mutation (G574A) in the chemokine receptor CXCR4 detected in human cancer cells enhances migration
The chemokine receptor CXCR4 is widely expressed in human cancers and regulates cell invasion, proliferation and survival. Because mutations in the CXCR4 gene could regulate its function we sequenced the coding region of the CXCR4 gene in 18 human melanoma and 3 human colon carcinoma cell lines. The same somatic point mutation (G574A; V160I) in the fourth transmembrane region of CXCR4 was detected in one colon cancer cell line (PD) and one melanoma cell line (LB). CXCR4 was expressed and functional in both PD and LB cells, PD and LB cells migrated specifically toward the receptor ligand, CXCL12 and P-Erk was specifically induced by CXCL12. To give insight into the function of the mutant CXCR4 receptor, human A431, epidermoid carcinoma cells, were stably transfected with both mutant and wild type CXCR4. In vitro, A431 cells harboring CXCR4(G574A) migrated specifically toward CXCL12 and CXCL12 induced ERK phosphorylation. Interestingly, in vivo studies showed that the growth of A431 tumors harboring CXCR4(G574A) was delayed compared to those harboring WT CXCR4. As expected, treatment with AMD3100, a specific CXCR4 inhibitor, reduced the in vivo growth of CXCR4(G574A) tumor b(G574A) but surprisingly, increased the growth of CXCR4(G574A) A431 cells. This is the first report of a spontaneously occurring, functionally active CXCR4 mutation in human cancer cells. While the mutation impairs cell growth in vivo, the CXCR4 inhibitor, AMD3100, stimulated the growth of cells harboring CXCR4(G574A).
The chemokine receptor CXCR4 is widely expressed in human cancers and regulates cell invasion, proliferation and survival. Because mutations in the CXCR4 gene could regulate its function we sequenced the coding region of the CXCR4 gene in 18 human melanoma and 3 human colon carcinoma cell lines. The same somatic point mutation (G574A; V160I) in the fourth transmembrane region of CXCR4 was detected in one colon cancer cell line (PD) and one melanoma cell line (LB). CXCR4 was expressed and functional in both PD and LB cells, PD and LB cells migrated specifically toward the receptor ligand, CXCL12 and P-Erk was specifically induced by CXCL12. To give insight into the function of the mutant CXCR4 receptor, human A431, epidermoid carcinoma cells, were stably transfected with both mutant and wild type CXCR4. In vitro, A431 cells harboring CXCR4(G574A) migrated specifically toward CXCL12 and CXCL12 induced ERK phosphorylation. Interestingly, in vivo studies showed that the growth of A431 tumors harboring CXCR4(G574A) was delayed compared to those harboring WT CXCR4. As expected, treatment with AMD3100, a specific CXCR4 inhibitor, reduced the in vivo growth of CXCR4(G574A) tumor b(G574A) but surprisingly, increased the growth of CXCR4(G574A) A431 cells. This is the first report of a spontaneously occurring, functionally active CXCR4 mutation in human cancer cells. While the mutation impairs cell growth in vivo, the CXCR4 inhibitor, AMD3100, stimulated the growth of cells harboring CXCR4(G574A).
A point mutation (G574A) in the chemokine receptor CXCR4 detected in human cancer cells enhances migration
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A point mutation (G574A) in the chemokine receptor CXCR4 detected in human cancer cells enhances migration
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* Decoy molecules based on PNA-DNA chimeras and targeting Sp1 transcription factors inhibit the activity of urokinase-type plasminogen activator receptor (uPAR) promoter (513 views)
Oncology Research (ISSN: 0965-0407), 2005; 15(7-8): 373-383.
Impact Factor: 1.844
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Russo M, Tedesco I, Iacomino G, Palumbo R, Galano G, Russo GL
* Dietary phytochemicals in chemoprevention of cancer (503 views)
Curr Med Chem (ISSN: 1568-0134), 2005; 5(1): 61-72.
Impact Factor: 3.715
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Palladino P, Pedone C, Ragone R, Rossi F, Saviano M, Benedetti E
* A simplified model of the binding interaction between stromal cell-derived factor-1 chemokine and CXC chemokine receptor (438 views)
Protein Pept Lett (ISSN: 0929-8665, 1875-5305), 2003 Apr; 10(2): 133-138.
Impact Factor: 0.46
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Palladino P, De Capua A, Pedone C, Ragone R, Rossi F, Limatola C, Ragozzino D, Benedetti E
* A simplified model of the interaction between SDF-1 chemokine and the CXCR4 receptor (571 views)
Peptide Revolution, 2003 Apr; 10(2): 133-138.
Impact Factor: 4.659
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Nastro P, Sodo M, Dodaro CA, Gargiulo S, Acampa W, Bracale U, Renda A
* Intraoperative radiochromoguided mapping of sentinel lymph node in colon cancer (285 views)
Tumori (ISSN: 0300-8916, 0300-8916print, 0300-8916linking), 2002 Jul; 88(4): 352-353.
Impact Factor: 0.267
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Herscher LL, Cook JA, Pacelli R, Pass HI, Russo A, Mitchell JB
Principles of chemoradiation: Theoretical and practical considerations (503 views)
Oncology (ISSN: 0890-9091), 1999 Oct; 13(10SUPPL.5): 11-22.
Impact Factor: 0.933
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Russo GL, Della Pietra V, Mercurio C, Palumbo R, Iacomino G, Russo M, Tosto M, Zappia V
Protective effects of butyric acid in colon cancer (424 views)
Adv Exp Med Biol (ISSN: 0065-2598print, 0065-2598linking), 1999; 472: 131-147.
Impact Factor: 0.446
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Salvatore M, Lastoria S, Del Vecchio S, Mansi L
Detection of colon cancer with radiolabelled monoclonal antibodies (420 views)
Nucl Med Biol (ISSN: 0883-2897, 0969-8051), 1989; 16(2): 103-104.
Impact Factor: 1.042
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28 Records (26 excluding Abstracts).
Total impact factor: 91.52 (87.986 excluding Abstracts).
Total 5 year impact factor: 86.772 (82.757 excluding Abstracts).
Total impact factor: 91.52 (87.986 excluding Abstracts).
Total 5 year impact factor: 86.772 (82.757 excluding Abstracts).
446 views. Last view on Saturday 14 September 2024, 22:21:00
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