A thermodynamic approach to the conformational preferences of the 180-195 segment derived from the human prion protein α2-helix (286 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009; 15(1): 30-35.
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Paper type: Journal Article,
Impact factor: 1.807, 5-year impact factor: 1.872
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-61749083187&partnerID=40&md5=8210b7cb614a6a772db689e99a40f328
Keywords: α2-Helix, β-Sheet, Amyloid, Cd Titration, Prion Protein, Prion Toxicity, Structure-Inducing Agents, Transmissible Spongiform Encephalopathies, Alanine, Alpha Helix, Amino Acid Substitution, Amino Terminal Sequence, Article, Carboxy Terminal Sequence, Circular Dichroism, Conformational Transition, Controlled Study, Priority Journal, Protein Conformation, Protein Stability, Protein Structure, Quantitative Analysis, Thermodynamics, Wild Type, Amino Acid Sequence, Humans, Models, Molecular, Molecular Sequence Data, Peptide Fragments, Secondary, Tertiary,
Affiliations:
*** IBB - CNR ***
Dipartimento delle Scienze Biologiche, C.I.R.Pe.B., Università Federico II di Napoli, Via Mezzocannone 16, Naples 80134, Italy
References:
PrusinerSB.Prions.Proc.Natl.Acad.Sci.U.S.A. 1998
95:13363-13383Will, R.G., Ironside, J.W., Zeidler, M., Cousens, S.N., Estibeiro, K., Alperovitch, A., Poser, S., Smith, P.G., A new variant of Creutzfeldt-Jakob disease in the UK (1996) Lancet, 347, pp. 921-92
Collinge, J., Sidle, K.C., Meads, J., Ironside, J., Hill, A.F., Molecular analysis of prion strain variation and the aetiology of 'new variant' CJD (1996) Nature, 383, pp. 685-690
Bruce, M.E., Will, R.G., Ironside, J.W., McConnell, I., Drummond, D., Suttie, A., McCardle, L., Bostock, C.J., Transmissions to mice indicate that 'new variant' CJD is caused by the BSE agent (1997) Nature, 389, pp. 498-501
Temussi, P.A., Masino, L., Pastore, A., From Alzheimer to Huntington: Why is a structural understanding so difficult? (2003) EMBO J, 22, pp. 355-361
Tizzano, B., Palladino, P., De Capua, A., Marasco, D., Rossi, F., Benedetti, E., Pedone, C., Ruvo, M., The human prion protein alpha2 helix: A thermodynamic study of its conformational preferences (2005) Proteins, 59, pp. 72-79
Thompson, A., White, A.R., McLean, C., Masters, C.L., Cappai, R., Barrow, C.J., Amyloidogenicity and neurotoxicity of peptides corresponding to the helical regions of PrP(C) (2000) J. Neurosci. Res, 62, pp. 293-301
Ronga, L., Palladino, P., Saviano, G., Tancredi, T., Benedetti, E., Ragone, R., Rossi, F., NMR structure and CD titration with metal cations of human prion alpha2-helix-related peptides (2007) Bioinorg. Chem. Appl, p. 10720
Ronga, L., Langella, E., Palladino, P., Marasco, D., Tizzano, B., Saviano, M., Pedone, C., Ruvo, M., Does tetracycline bind helix 2 of prion? An integrated spectroscopical and computational study of the interaction between the antibiotic and alpha helix 2 human prion protein fragments (2007) Proteins, 66, pp. 707-715
Lu, X., Wintrode, P.L., Surewicz, W.K., Beta-sheet core of human prion protein amyloid fibrils as determined by hydrogen/deuterium exchange (2007) Proc. Natl. Acad. Sci. U.S.A, 104, pp. 1510-1515
Haire, L.F., Whyte, S.M., Vasisht, N., Gill, A.C., Verma, C., Dodson, E.J., Dodson, G.G., Bayley, P.M., The crystal structure of the globular domain of sheep prion protein (2004) J. Mol. Biol, 336, pp. 1175-1183
Zhong, L., Johnson Jr., W.C., Environment affects amino acid preference for secondary structure (1992) Proc. Natl. Acad. Sci. U.S.A, 89, pp. 4462-4465
Wu, C.S., Yang, J.T., Sequence-dependent conformations of short polypeptides in a hydrophobic environment (1981) Mol. Cell. Biochem, 40, pp. 109-122
Wu, C.S., Ikeda, K., Yang, J.T., Ordered conformation of polypeptides and proteins in acidic dodecyl sulfate solution (1981) Biochemistry, 20, pp. 566-570
Esposito, C., Colicchio, P., Facchiano, A., Ragone, R., Effect of a weak electrolyte on the critical micellar concentration of sodium dodecyl sulfate (1998) J. Colloid Interface Sci, 200, pp. 310-312
Le Maire, M., Champeil, P., Møller, J.V., Interaction of membrane proteins and lipids with solubilizing detergents (2000) Biochim. Biophys. Acta, 1508, pp. 86-111
Kuroda, Y., Maeda, Y., Sawa, S., Shibata, K., Miyamoto, K., Nakagawa, T., Effects of detergents on the secondary structures of prion protein peptides as studied by CD spectroscopy (2003) J. Pept. Sci, 9, pp. 212-220
Santoro, M.M., Bolen, D.W., Unfolding free energy changes determined by the linear extrapolation method. 1. Unfolding of phenylmethanesulfonyl alpha-chymotrypsin using different denaturants (1988) Biochemistry, 27, pp. 8063-8068
Eftink, M.R., The use of fluorescence methods to monitor unfolding transitions in proteins (1994) Biophys. J, 66, pp. 482-501
Bordbar, A.K., Saboury, A.A., Housaindokht, M.R., Moosavi-Movahedi, A.A., Statistical effects of the binding of ionic surfactant to protein (1997) J. Colloid Interface Sci, 192, pp. 415-419
Ambrosone, L., Ragone, R., The interaction of micelles with added species andits similarity to the denaturant binding model of proteins (1998) J. Colloid Interface Sci, 205, pp. 454-458
Nelson, J.W., Kallenbach, N.R., Stabilization of the ribonuclease S-peptide α-helix by trifluoroethanol (1986) Proteins, 1, pp. 211-217
Merutka, G., Stellwagen, E., Analysis of peptides for helical prediction (1989) Biochemistry, 28, pp. 352-357
Roccatano, D., Colombo, G., Fioroni, M., Mark, A.E., Mechanism by which 2,2,2-trifluoroethanol/water mixtures stabilize secondary-structure formation in peptides: A molecular dynamics study (2002) Proc. Natl. Acad. Sci. U.S.A, 99, pp. 12179-12184
Jasanoff, A., Fersht, A.R., Quantitative determination of helical propensities from trifluoroethanol titration curves (1994) Biochemistry, 33, pp. 2129-2135
Schönbrunner, N., Wey, J., Engels, J., Georg, H., Kiefhaber, T., Native-like β-structure in a trifluoroethanol-induced partially folded state of the all-β-sheet protein tendamistat (1996) J. Mol. Biol, 260, pp. 432-445
Trifluoroethanol, B.M., cosolvents come of age. Recent studies with peptides and proteins (1998) Q. Rev. Biophys, 31, pp. 297-355
Yang, J.T., Wu, C.S.C., Martinez, H.M., Calculation of protein conformation from circular dichroism (1986) Methods Enzymol, 130, pp. 208-269
Tanford, C., Protein denaturation. C. Theoretical models for the mechanism of denaturation (1970) Adv. Protein Chem, 24, pp. 1-95
Wu, J.W., Wang, Z.X., New evidence for the denaturant binding model (1999) Protein Sci, 8, pp. 2090-2097
Schellman, J.A., Selective binding and solvent denaturation (1987) Biopolymers, 26, pp. 549-559
Swietnicki, W., Petersen, R., Gambetti, P., Surewicz, W.K., pH-dependent stability and conformation of the recombinant human prion protein PrP(90-231) (1997) J. Biol. Chem, 272, pp. 27517-27520
Hornemann, S., Glockshuber, R., A scrapie-like unfolding intermediate of the prion protein domain PrP(121-231) induced by acidic pH (1998) Proc. Natl. Acad. Sci. U.S.A, 95, pp. 6010-6014
Swietnicki, W., Morillas, M., Chen, S.G., Gambetti, P., Surewicz, W.K., Aggregation and fibrillization of the recombinant human prion protein huPrP90-231 (2000) Biochemistry, 39, pp. 424-431
Zou, W.-Q., Cashman, N.R., Acidic pH and detergents enhance in vitro conversion of human brain PrPC to a PrPSc-like form (2002) J. Biol. Chem, 277, pp. 43942-43947
Langella, E., Improta, R., Barone, V., Checking the pH-induced conformational transition of prion protein by molecular dynamics simulations: Effect of protonation of histidine residues (2004) Biophys. J, 87, pp. 3623-3632
Borchelt, D.R., Taraboulos, A., Prusiner, S.B., Evidence for synthesis of scrapie prion proteins in the endocytic pathway (1992) J. Biol. Chem, 267, pp. 16188-16199
Knaus, K.J., Morillas, M., Swietnicki, W., Malone, M., Surewicz, W.K., Yee, V.C., Crystal structure of the human prion protein reveals a mechanism for oligomerization (2001) Nat. Struct. Biol, 8, pp. 770-774
Wopfner, F., Weidenhöfer, G., Schneider, R., von Brunn, A., Gilch, S., Schwarz, T.F., Werner, T., Schätz, H.M., Analysis of 27 mammalian and 9 avian PrPs reveals high conservation of flexible regions of the prion protein (1999) J. Mol. Biol, 289, pp. 1163-1178
PrusinerSB. Prions. Proc. Natl. Acad. Sci. U. S. A. 1998
95: 13363-13383Will, R. G., Ironside, J. W., Zeidler, M., Cousens, S. N., Estibeiro, K., Alperovitch, A., Poser, S., Smith, P. G., A new variant of Creutzfeldt-Jakob disease in the UK (1996) Lancet, 347, pp. 921-92
Bruce, M. E., Will, R. G., Ironside, J. W., McConnell, I., Drummond, D., Suttie, A., McCardle, L., Bostock, C. J., Transmissions to mice indicate that 'new variant' CJD is caused by the BSE agent (1997) Nature, 389, pp. 498-501
Temussi, P. A., Masino, L., Pastore, A., From Alzheimer to Huntington: Why is a structural understanding so difficult? (2003) EMBO J, 22, pp. 355-361
Haire, L. F., Whyte, S. M., Vasisht, N., Gill, A. C., Verma, C., Dodson, E. J., Dodson, G. G., Bayley, P. M., The crystal structure of the globular domain of sheep prion protein (2004) J. Mol. Biol, 336, pp. 1175-1183
Wu, C. S., Yang, J. T., Sequence-dependent conformations of short polypeptides in a hydrophobic environment (1981) Mol. Cell. Biochem, 40, pp. 109-122
Wu, C. S., Ikeda, K., Yang, J. T., Ordered conformation of polypeptides and proteins in acidic dodecyl sulfate solution (1981) Biochemistry, 20, pp. 566-570
Santoro, M. M., Bolen, D. W., Unfolding free energy changes determined by the linear extrapolation method. 1. Unfolding of phenylmethanesulfonyl alpha-chymotrypsin using different denaturants (1988) Biochemistry, 27, pp. 8063-8068
Eftink, M. R., The use of fluorescence methods to monitor unfolding transitions in proteins (1994) Biophys. J, 66, pp. 482-501
Bordbar, A. K., Saboury, A. A., Housaindokht, M. R., Moosavi-Movahedi, A. A., Statistical effects of the binding of ionic surfactant to protein (1997) J. Colloid Interface Sci, 192, pp. 415-419
Nelson, J. W., Kallenbach, N. R., Stabilization of the ribonuclease S-peptide -helix by trifluoroethanol (1986) Proteins, 1, pp. 211-217
Sch nbrunner, N., Wey, J., Engels, J., Georg, H., Kiefhaber, T., Native-like -structure in a trifluoroethanol-induced partially folded state of the all- -sheet protein tendamistat (1996) J. Mol. Biol, 260, pp. 432-445
Yang, J. T., Wu, C. S. C., Martinez, H. M., Calculation of protein conformation from circular dichroism (1986) Methods Enzymol, 130, pp. 208-269
Wu, J. W., Wang, Z. X., New evidence for the denaturant binding model (1999) Protein Sci, 8, pp. 2090-2097
Schellman, J. A., Selective binding and solvent denaturation (1987) Biopolymers, 26, pp. 549-559
Zou, W. -Q., Cashman, N. R., Acidic pH and detergents enhance in vitro conversion of human brain PrPC to a PrPSc-like form (2002) J. Biol. Chem, 277, pp. 43942-43947
Borchelt, D. R., Taraboulos, A., Prusiner, S. B., Evidence for synthesis of scrapie prion proteins in the endocytic pathway (1992) J. Biol. Chem, 267, pp. 16188-16199
Knaus, K. J., Morillas, M., Swietnicki, W., Malone, M., Surewicz, W. K., Yee, V. C., Crystal structure of the human prion protein reveals a mechanism for oligomerization (2001) Nat. Struct. Biol, 8, pp. 770-774
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009; 15(1): 30-35.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 1.807, 5-year impact factor: 1.872
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-61749083187&partnerID=40&md5=8210b7cb614a6a772db689e99a40f328
Keywords: α2-Helix, β-Sheet, Amyloid, Cd Titration, Prion Protein, Prion Toxicity, Structure-Inducing Agents, Transmissible Spongiform Encephalopathies, Alanine, Alpha Helix, Amino Acid Substitution, Amino Terminal Sequence, Article, Carboxy Terminal Sequence, Circular Dichroism, Conformational Transition, Controlled Study, Priority Journal, Protein Conformation, Protein Stability, Protein Structure, Quantitative Analysis, Thermodynamics, Wild Type, Amino Acid Sequence, Humans, Models, Molecular, Molecular Sequence Data, Peptide Fragments, Secondary, Tertiary,
Affiliations:
*** IBB - CNR ***
Dipartimento delle Scienze Biologiche, C.I.R.Pe.B., Università Federico II di Napoli, Via Mezzocannone 16, Naples 80134, Italy
References:
PrusinerSB.Prions.Proc.Natl.Acad.Sci.U.S.A. 1998
95:13363-13383Will, R.G., Ironside, J.W., Zeidler, M., Cousens, S.N., Estibeiro, K., Alperovitch, A., Poser, S., Smith, P.G., A new variant of Creutzfeldt-Jakob disease in the UK (1996) Lancet, 347, pp. 921-92
Collinge, J., Sidle, K.C., Meads, J., Ironside, J., Hill, A.F., Molecular analysis of prion strain variation and the aetiology of 'new variant' CJD (1996) Nature, 383, pp. 685-690
Bruce, M.E., Will, R.G., Ironside, J.W., McConnell, I., Drummond, D., Suttie, A., McCardle, L., Bostock, C.J., Transmissions to mice indicate that 'new variant' CJD is caused by the BSE agent (1997) Nature, 389, pp. 498-501
Temussi, P.A., Masino, L., Pastore, A., From Alzheimer to Huntington: Why is a structural understanding so difficult? (2003) EMBO J, 22, pp. 355-361
Tizzano, B., Palladino, P., De Capua, A., Marasco, D., Rossi, F., Benedetti, E., Pedone, C., Ruvo, M., The human prion protein alpha2 helix: A thermodynamic study of its conformational preferences (2005) Proteins, 59, pp. 72-79
Thompson, A., White, A.R., McLean, C., Masters, C.L., Cappai, R., Barrow, C.J., Amyloidogenicity and neurotoxicity of peptides corresponding to the helical regions of PrP(C) (2000) J. Neurosci. Res, 62, pp. 293-301
Ronga, L., Palladino, P., Saviano, G., Tancredi, T., Benedetti, E., Ragone, R., Rossi, F., NMR structure and CD titration with metal cations of human prion alpha2-helix-related peptides (2007) Bioinorg. Chem. Appl, p. 10720
Ronga, L., Langella, E., Palladino, P., Marasco, D., Tizzano, B., Saviano, M., Pedone, C., Ruvo, M., Does tetracycline bind helix 2 of prion? An integrated spectroscopical and computational study of the interaction between the antibiotic and alpha helix 2 human prion protein fragments (2007) Proteins, 66, pp. 707-715
Lu, X., Wintrode, P.L., Surewicz, W.K., Beta-sheet core of human prion protein amyloid fibrils as determined by hydrogen/deuterium exchange (2007) Proc. Natl. Acad. Sci. U.S.A, 104, pp. 1510-1515
Haire, L.F., Whyte, S.M., Vasisht, N., Gill, A.C., Verma, C., Dodson, E.J., Dodson, G.G., Bayley, P.M., The crystal structure of the globular domain of sheep prion protein (2004) J. Mol. Biol, 336, pp. 1175-1183
Zhong, L., Johnson Jr., W.C., Environment affects amino acid preference for secondary structure (1992) Proc. Natl. Acad. Sci. U.S.A, 89, pp. 4462-4465
Wu, C.S., Yang, J.T., Sequence-dependent conformations of short polypeptides in a hydrophobic environment (1981) Mol. Cell. Biochem, 40, pp. 109-122
Wu, C.S., Ikeda, K., Yang, J.T., Ordered conformation of polypeptides and proteins in acidic dodecyl sulfate solution (1981) Biochemistry, 20, pp. 566-570
Esposito, C., Colicchio, P., Facchiano, A., Ragone, R., Effect of a weak electrolyte on the critical micellar concentration of sodium dodecyl sulfate (1998) J. Colloid Interface Sci, 200, pp. 310-312
Le Maire, M., Champeil, P., Møller, J.V., Interaction of membrane proteins and lipids with solubilizing detergents (2000) Biochim. Biophys. Acta, 1508, pp. 86-111
Kuroda, Y., Maeda, Y., Sawa, S., Shibata, K., Miyamoto, K., Nakagawa, T., Effects of detergents on the secondary structures of prion protein peptides as studied by CD spectroscopy (2003) J. Pept. Sci, 9, pp. 212-220
Santoro, M.M., Bolen, D.W., Unfolding free energy changes determined by the linear extrapolation method. 1. Unfolding of phenylmethanesulfonyl alpha-chymotrypsin using different denaturants (1988) Biochemistry, 27, pp. 8063-8068
Eftink, M.R., The use of fluorescence methods to monitor unfolding transitions in proteins (1994) Biophys. J, 66, pp. 482-501
Bordbar, A.K., Saboury, A.A., Housaindokht, M.R., Moosavi-Movahedi, A.A., Statistical effects of the binding of ionic surfactant to protein (1997) J. Colloid Interface Sci, 192, pp. 415-419
Ambrosone, L., Ragone, R., The interaction of micelles with added species andits similarity to the denaturant binding model of proteins (1998) J. Colloid Interface Sci, 205, pp. 454-458
Nelson, J.W., Kallenbach, N.R., Stabilization of the ribonuclease S-peptide α-helix by trifluoroethanol (1986) Proteins, 1, pp. 211-217
Merutka, G., Stellwagen, E., Analysis of peptides for helical prediction (1989) Biochemistry, 28, pp. 352-357
Roccatano, D., Colombo, G., Fioroni, M., Mark, A.E., Mechanism by which 2,2,2-trifluoroethanol/water mixtures stabilize secondary-structure formation in peptides: A molecular dynamics study (2002) Proc. Natl. Acad. Sci. U.S.A, 99, pp. 12179-12184
Jasanoff, A., Fersht, A.R., Quantitative determination of helical propensities from trifluoroethanol titration curves (1994) Biochemistry, 33, pp. 2129-2135
Schönbrunner, N., Wey, J., Engels, J., Georg, H., Kiefhaber, T., Native-like β-structure in a trifluoroethanol-induced partially folded state of the all-β-sheet protein tendamistat (1996) J. Mol. Biol, 260, pp. 432-445
Trifluoroethanol, B.M., cosolvents come of age. Recent studies with peptides and proteins (1998) Q. Rev. Biophys, 31, pp. 297-355
Yang, J.T., Wu, C.S.C., Martinez, H.M., Calculation of protein conformation from circular dichroism (1986) Methods Enzymol, 130, pp. 208-269
Tanford, C., Protein denaturation. C. Theoretical models for the mechanism of denaturation (1970) Adv. Protein Chem, 24, pp. 1-95
Wu, J.W., Wang, Z.X., New evidence for the denaturant binding model (1999) Protein Sci, 8, pp. 2090-2097
Schellman, J.A., Selective binding and solvent denaturation (1987) Biopolymers, 26, pp. 549-559
Swietnicki, W., Petersen, R., Gambetti, P., Surewicz, W.K., pH-dependent stability and conformation of the recombinant human prion protein PrP(90-231) (1997) J. Biol. Chem, 272, pp. 27517-27520
Hornemann, S., Glockshuber, R., A scrapie-like unfolding intermediate of the prion protein domain PrP(121-231) induced by acidic pH (1998) Proc. Natl. Acad. Sci. U.S.A, 95, pp. 6010-6014
Swietnicki, W., Morillas, M., Chen, S.G., Gambetti, P., Surewicz, W.K., Aggregation and fibrillization of the recombinant human prion protein huPrP90-231 (2000) Biochemistry, 39, pp. 424-431
Zou, W.-Q., Cashman, N.R., Acidic pH and detergents enhance in vitro conversion of human brain PrPC to a PrPSc-like form (2002) J. Biol. Chem, 277, pp. 43942-43947
Langella, E., Improta, R., Barone, V., Checking the pH-induced conformational transition of prion protein by molecular dynamics simulations: Effect of protonation of histidine residues (2004) Biophys. J, 87, pp. 3623-3632
Borchelt, D.R., Taraboulos, A., Prusiner, S.B., Evidence for synthesis of scrapie prion proteins in the endocytic pathway (1992) J. Biol. Chem, 267, pp. 16188-16199
Knaus, K.J., Morillas, M., Swietnicki, W., Malone, M., Surewicz, W.K., Yee, V.C., Crystal structure of the human prion protein reveals a mechanism for oligomerization (2001) Nat. Struct. Biol, 8, pp. 770-774
Wopfner, F., Weidenhöfer, G., Schneider, R., von Brunn, A., Gilch, S., Schwarz, T.F., Werner, T., Schätz, H.M., Analysis of 27 mammalian and 9 avian PrPs reveals high conservation of flexible regions of the prion protein (1999) J. Mol. Biol, 289, pp. 1163-1178
PrusinerSB. Prions. Proc. Natl. Acad. Sci. U. S. A. 1998
95: 13363-13383Will, R. G., Ironside, J. W., Zeidler, M., Cousens, S. N., Estibeiro, K., Alperovitch, A., Poser, S., Smith, P. G., A new variant of Creutzfeldt-Jakob disease in the UK (1996) Lancet, 347, pp. 921-92
Bruce, M. E., Will, R. G., Ironside, J. W., McConnell, I., Drummond, D., Suttie, A., McCardle, L., Bostock, C. J., Transmissions to mice indicate that 'new variant' CJD is caused by the BSE agent (1997) Nature, 389, pp. 498-501
Temussi, P. A., Masino, L., Pastore, A., From Alzheimer to Huntington: Why is a structural understanding so difficult? (2003) EMBO J, 22, pp. 355-361
Haire, L. F., Whyte, S. M., Vasisht, N., Gill, A. C., Verma, C., Dodson, E. J., Dodson, G. G., Bayley, P. M., The crystal structure of the globular domain of sheep prion protein (2004) J. Mol. Biol, 336, pp. 1175-1183
Wu, C. S., Yang, J. T., Sequence-dependent conformations of short polypeptides in a hydrophobic environment (1981) Mol. Cell. Biochem, 40, pp. 109-122
Wu, C. S., Ikeda, K., Yang, J. T., Ordered conformation of polypeptides and proteins in acidic dodecyl sulfate solution (1981) Biochemistry, 20, pp. 566-570
Santoro, M. M., Bolen, D. W., Unfolding free energy changes determined by the linear extrapolation method. 1. Unfolding of phenylmethanesulfonyl alpha-chymotrypsin using different denaturants (1988) Biochemistry, 27, pp. 8063-8068
Eftink, M. R., The use of fluorescence methods to monitor unfolding transitions in proteins (1994) Biophys. J, 66, pp. 482-501
Bordbar, A. K., Saboury, A. A., Housaindokht, M. R., Moosavi-Movahedi, A. A., Statistical effects of the binding of ionic surfactant to protein (1997) J. Colloid Interface Sci, 192, pp. 415-419
Nelson, J. W., Kallenbach, N. R., Stabilization of the ribonuclease S-peptide -helix by trifluoroethanol (1986) Proteins, 1, pp. 211-217
Sch nbrunner, N., Wey, J., Engels, J., Georg, H., Kiefhaber, T., Native-like -structure in a trifluoroethanol-induced partially folded state of the all- -sheet protein tendamistat (1996) J. Mol. Biol, 260, pp. 432-445
Yang, J. T., Wu, C. S. C., Martinez, H. M., Calculation of protein conformation from circular dichroism (1986) Methods Enzymol, 130, pp. 208-269
Wu, J. W., Wang, Z. X., New evidence for the denaturant binding model (1999) Protein Sci, 8, pp. 2090-2097
Schellman, J. A., Selective binding and solvent denaturation (1987) Biopolymers, 26, pp. 549-559
Zou, W. -Q., Cashman, N. R., Acidic pH and detergents enhance in vitro conversion of human brain PrPC to a PrPSc-like form (2002) J. Biol. Chem, 277, pp. 43942-43947
Borchelt, D. R., Taraboulos, A., Prusiner, S. B., Evidence for synthesis of scrapie prion proteins in the endocytic pathway (1992) J. Biol. Chem, 267, pp. 16188-16199
Knaus, K. J., Morillas, M., Swietnicki, W., Malone, M., Surewicz, W. K., Yee, V. C., Crystal structure of the human prion protein reveals a mechanism for oligomerization (2001) Nat. Struct. Biol, 8, pp. 770-774
A thermodynamic approach to the conformational preferences of the 180-195 segment derived from the human prion protein α2-helix
On consideration that intrinsic structural weakness could affect the segment spanning the α2-helical residues 173-195 of the PrP, we have investigated the conformational stabilities of some synthetic Ala-scanned analogs of the peptide derived from the 180-195 C-terminal sequence, using a novel approach whose theoretical basis originates from protein thermodynamics. Even though a quantitative comparison among peptides could not be assessed to rank them according to the effect caused by single amino acid substitution, as a general trend, all peptides invariably showed an appreciable preference for an α-type organization, consistently with the fact that the wild-type sequence is organized as an α-helix in the native protein. Moreover, the substitution of whatever single amino acid in the wild-type sequence reduced the gap between the α- and the β-propensity, invariably enhancing the latter, but in any case this gap was larger than that evaluated for the full-length α2-helix-derived peptide. It appears that the low β-conformation propensity of the 180-195 region depends on the simultaneous presence of all of the Ala-scanned residues, indirectly confirming that the N-terminal 173-179 segment could play a major role in determining the chameleon conformational behavior of the entire 173-195 region in the PrP. Copyright © 2008 European Peptide Society and John Wiley & Sons, Ltd.
On consideration that intrinsic structural weakness could affect the segment spanning the α2-helical residues 173-195 of the PrP, we have investigated the conformational stabilities of some synthetic Ala-scanned analogs of the peptide derived from the 180-195 C-terminal sequence, using a novel approach whose theoretical basis originates from protein thermodynamics. Even though a quantitative comparison among peptides could not be assessed to rank them according to the effect caused by single amino acid substitution, as a general trend, all peptides invariably showed an appreciable preference for an α-type organization, consistently with the fact that the wild-type sequence is organized as an α-helix in the native protein. Moreover, the substitution of whatever single amino acid in the wild-type sequence reduced the gap between the α- and the β-propensity, invariably enhancing the latter, but in any case this gap was larger than that evaluated for the full-length α2-helix-derived peptide. It appears that the low β-conformation propensity of the 180-195 region depends on the simultaneous presence of all of the Ala-scanned residues, indirectly confirming that the N-terminal 173-179 segment could play a major role in determining the chameleon conformational behavior of the entire 173-195 region in the PrP. Copyright © 2008 European Peptide Society and John Wiley & Sons, Ltd.
A thermodynamic approach to the conformational preferences of the 180-195 segment derived from the human prion protein α2-helix
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A thermodynamic approach to the conformational preferences of the 180-195 segment derived from the human prion protein α2-helix
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Di Natale C, La Manna S, Avitabile C, Florio D, Morelli G, Netti PA, Marasco D
* Corrigendum to "Engineered β-hairpin scaffolds from human prion protein regions: Structural and functional investigations of aggregates" [Bioorg. Chem. 96 (2020) 103594] (36 views)
Bioorg Chem (ISSN: 0045-2068linking, 1090-2120electronic), 2020 Jun; 99: 103853-103853.
Impact Factor: 3.119
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Di Natale C, La Manna S, Avitabile C, Florio D, Morelli G, Netti PA, Marasco D
* Engineered β-hairpin scaffolds from human prion protein regions: Structural and functional investigations of aggregates (58 views)
Bioorg Chem (ISSN: 0045-2068linking, 1090-2120electronic), 2020 Mar; 96: 103594-103594.
Impact Factor: 4.831
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Dell'Acqua S, Bacchella C, Monzani E, Nicolis S, Di Natale G, Rizzarelli E, Casella L
* Prion Peptides Are Extremely Sensitive to Copper Induced Oxidative Stress (583 views)
Inorg Chem (ISSN: 0020-1669, 1520-510x, 0020-1669linking), 2017 Sep 18; 56(18): 11317-11325.
Impact Factor: 4.7
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Di Natale G, Turi I, Pappalardo G, Sóvágó I, Rizzarelli E
* Cross-Talk Between the Octarepeat Domain and the Fifth Binding Site of Prion Protein Driven by the Interaction of Copper(II) with the N-terminus (454 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2015 Mar 2; 21(10): 4071-4084.
Impact Factor: 5.771
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Benetti F, Biarnés X, Attanasio F, Giachin G, Rizzarelli E, Legname G
* Structural determinants in prion protein folding and stability (596 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 0022-2836linking), 2014 Nov 11; 426(22): 3796-3810.
Impact Factor: 4.333
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La Mendola D, Rizzarelli E
* Evolutionary implications of metal binding features in different species' prion protein: an inorganic point of view (354 views)
Biomolecules (ISSN: 2218-273x), 2014 May 23; 4(2): 546-565.
Impact Factor: 2.095
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De Simonea A, Stanzione F, Marasco D, Vitagliano L, Esposito L
* The Intrinsic Stability Of The Human Prion Beta-Sheet Region Investigated By Molecular Dynamics (608 views)
Journal Of Biomolecular Structure & Dynamics, 2013 May 1; 31(5): 441-452.
Impact Factor: 2.983
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Jószai V, Turi I, Kállay C, Pappalardo G, Di Natale G, Rizzarelli E, Sóvágó I
* Mixed metal copper(II)-nickel(II) and copper(II)-zinc(II) complexes of multihistidine peptide fragments of human prion protein (481 views)
J Chem Res (ISSN: 1873-3344, 0162-0134, 0162-0134print), 2012 Jul; 112: 17-24.
Impact Factor: 3.197
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Benetti F, Biarnes X, Attanasio F, Rizzarelli E, Laio A, Legname G
* Description and Characterization of a Highly Stable Enthalpic Intermediate State in Mouse Prion Protein Folding (306 views)
Prion (ISSN: 1933-6896), 2011 Apr; 5: N/D-N/D.
Impact Factor: 2.85
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Kállay C, Turi I, Timári S, Nagy Z, Sanna D, Pappalardo G, De Bona P, Rizzarelli E, Sóvágó I
* The effect of point mutations on copper(II) complexes with peptide fragments encompassing the 106-114 region of human prion protein (503 views)
Monatshefte Fur Chemie (ISSN: 0026-9247), 2011 Apr; 142(4): 411-419.
Impact Factor: 1.532
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Vagliasindi LI, Arena G, Bonomo RP, Pappalardo G, Tabbì G
* Copper complex species within a fragment of the N-terminal repeat region in opossum PrP protein (357 views)
Dalton T (ISSN: 1477-9226, 1477-9234, 1477-9234electronic), 2011 Mar 21; 40(11): 2441-2450.
Impact Factor: 3.838
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Di Natale G, Pappalardo G, Milardi D, Sciacca MF, Attanasio F, La Mendola D, Rizzarelli E
* Membrane interactions and conformational preferences of human and avian prion N-terminal tandem repeats: The role of copper(II) ions, pH, and membrane mimicking environments (494 views)
J Phys Chem B (ISSN: 1520-6106, 1520-5207, 1520-5207electronic), 2010 Nov 4; 114(43): 13830-13838.
Impact Factor: 3.603
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Turi I, Kállay C, Szikszai D, Pappalardo G, Di Natale G, De Bona P, Rizzarelli E, Sóvágó I
* Nickel(II) complexes of the multihistidine peptide fragments of human prion protein (480 views)
J Chem Res (ISSN: 1873-3344, 0162-0134, 0162-0134print), 2010 Sep; 104(8): 885-891.
Impact Factor: 3.317
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Benetti F, Pastorino L, Attanasio F, Rizzarelli E, Legname G
* Insights into Prion Protein Stability (267 views)
Prion (ISSN: 1933-6896), 2010 Jul; 4(3): N/D-N/D.
Impact Factor: 2.468
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La Mendola D, Magrì A, Campagna T, Campitiello MA, Raiola L, Isernia C, Hansson O, Bonomo RP, Rizzarelli E
* A doppel alpha-helix peptide fragment mimics the copper(II) interactions with the whole protein (1115 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2010 Jun 1; 16(21): 6212-6223.
Impact Factor: 5.476
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Di Natale G, Pappalardo G, Milardi D, Sciacca MFM, Attanasio F, La Mendola D, Rizzarelli E
* Different Interactions Of Human And Avian Prion Proteins N-Terminal Tandem Repeat Peptides And Their Copper (ii) Complexes With Model Membranes (385 views)
Journal Of Chemical Physics, 2010; 114: 13830-13838.
Impact Factor: 2.028
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Palladino P, Ronga L, Benedetti E, Rossi F, Ragone R
* Peptide Fragment Approach to Prion Misfolding: The Alpha-2 Domain (401 views)
Int J Pept Res Ther (ISSN: 1573-3149, 0929-5666), 2009 Sep; 15(3): 165-176.
Impact Factor: 0.869
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Pietropaolo A, Muccioli L, Zannoni C, Rizzarelli E
* Conformational preferences of the full chicken prion protein in solution and its differences with respect to mammals (381 views)
Chemphyschem (ISSN: 1439-7641, 1439-4235, 1439-7641electronic), 2009 Jul 13; 10(9-10): 1500-1510.
Impact Factor: 3.453
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La Mendola D, Pietropaolo A, Pappalardo G, Zannoni C, Rizzarelli E
* Prion Proteins Leading to Neurodegeneration (vol 5, pg 579, 2008) (233 views)
Current Alzheimer Research (ISSN: 1567-2050), 2009 Jun; 6(3): N/D-N/D.
Impact Factor: 4.971
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Di Natale G, Osz K, Nagy Z, Sanna D, Micera G, Pappalardo G, Sovago I, Rizzarelli E
* The Interaction Of Copper (ii) With The Prion Peptide Fragment Huprp (76-114) Encompassing Four Histidyl Residues Within And Outside The Octarepeat Domain (323 views)
Inorg Chem (ISSN: 0020-1669, 1520-510x, 1520-510xelectronic), 2009 May 4; 48(9): 4239-4250.
Impact Factor: 4.657
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La Mendola D, Magrì A, Hansson O, Bonomo RP, Rizzarelli E
* Copper(II) complexes with peptide fragments encompassing the sequence 122-130 of human doppel protein (361 views)
Journal Of Inorganic Biochemistry, 2009 May; 103(5): 758-765.
Impact Factor: 3.444
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Bonomo RP, Di Natale G, Rizzarelli E, Tabbì G, Vagliasindi LI
* Copper(II) complexes of prion protein PEG11-tetraoctarepeat fragment: spectroscopic and voltammetric studies (411 views)
Dalton T (ISSN: 1477-9226, 1477-7922, 1477-9234), 2009 Apr 14; (14): 2637-2646.
Impact Factor: 2.908
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La Mendola D, Pietropaolo A, Pappalardo G, Zannoni C, Rizzarelli E
* Prion proteins leading to neurodegeneration (420 views)
Current Alzheimer Research (ISSN: 1567-2050), 2008 Dec; 5(6): 579-590.
Impact Factor: 4.132
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Bonomo RP, Pappalardo G, Rizzarelli E, Tabbì G, Vagliasindi LI
* Studies of nitric oxide interaction with mono- and dinuclear copper(II) complexes of prion protein bis-octarepeat fragments (309 views)
Dalton T (ISSN: 1477-9226, 1477-9234, 1477-9234electronic), 2008 Sep 7; (29): 3805-3816.
Impact Factor: 3.58
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Pietropaolo A, Muccioli L, Zannoni C, La Mendola D, Maccarrone G, Pappalardo G, Rizzarelli E
* Unveiling the role of histidine and tyrosine residues on the conformation of the avian prion hexarepeat domain (343 views)
J Phys Chem B (ISSN: 1520-6106, 1520-5207, 1520-5207electronic), 2008 Apr 24; 112(16): 5182-5188.
Impact Factor: 4.189
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De Simone A, Pedone C, Vitagliano L
* Structure, dynamics, and stability of assemblies of the human prion fragment SNQNNF (503 views)
Biochem Biophys Res Commun (ISSN: 1090-2104, 0006-291x, 1090-2104electronic), 2008 Feb 15; 366(3): 800-806.
Impact Factor: 2.648
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Ronga L, Palladino P, Saviano G, Tancredi T, Benedetti E, Ragone R, Rossi F
* Structural characterization of a neurotoxic threonine-rich peptide corresponding to the human prion protein α2-helical 180-195 segment and comparison with full-length α2-helix-derived peptides (411 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2008; 14(10): 1096-1102.
Impact Factor: 1.654
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Bonomo RP, Pappalardo G, Rizzarelli E, Santoro AM, Tabbì G, Vagliasindi LI
* Nitrogen oxide interaction with copper complexes formed by small peptides belonging to the prion protein octa-repeat region (562 views)
Dalton T (ISSN: 1477-9226, 1477-9234, 1477-9234electronic), 2007 Apr 14; (14): 1400-1408.
Impact Factor: 3.212
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Ronga L, Langella E, Palladino P, Marasco D, Tizzano B, Saviano M, Pedone C, Improta R, Ruvo M
* Does Tetracycline Bind Helix 2 Of Prion? An Integrated Spectroscopical And Computational Study Of The Interaction Between The Antibiotic And Alpha Helix 2 Human Prion Protein Fragments (512 views)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2007 Feb 15; 66(3): 707-715.
Impact Factor: 3.354
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Ronga L, Palladino P, Costantini S, Facchiano A, Ruvo M, Benedetti E, Ragone R, Rossi F
* Conformational diseases and structure-toxicity relationships: Lessons from prion-derived peptides (553 views)
Curr Protein Pept Sci (ISSN: 1389-2037, 1389-2037linking), 2007 Feb; 8(1): 83-90.
Impact Factor: 3.259
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Rao M, Russo F, Granata V, Berisio R, Zagari A, Gianfreda L
* Fate of prions in soil: Interaction of a recombinant ovine prion protein with synthetic humic-like mineral complexes (426 views)
Soil Biol Biochem (ISSN: 0038-0717), 2007 Feb; 39(2): 493-504.
Impact Factor: 2.58
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Osz K, Nagy Z, Pappalardo G, Di Natale G, Sanna D, Micera G, Rizzarelli E, Sóvágó I
* Copper(II) interaction with prion peptide fragments encompassing histidine residues within and outside the octarepeat domain: speciation, stability constants and binding details (549 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2007; 13(25): 7129-7143.
Impact Factor: 5.33
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Ronga L, Palladino P, Saviano G, Tancredi T, Benedetti E, Ragone R, Rossi F
* NMR structure and CD titration with metal cations of human prion α2-helix-related peptides (465 views)
Bioinorg Chem Appl (ISSN: 1565-3633), 2007; 2007: N/D-N/D.
Impact Factor: 0.978
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Pappalardo M, Milardi D, Grasso D, La Rosa C
* Steered molecular dynamics studies reveal different unfolding pathways of prions from mammalian and non-mammalian species (338 views)
New J Chem (ISSN: 1144-0546), 2007; 31(6): 901-905.
Impact Factor: 2.651
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Ronga L, Palladino P, Tizzano B, Marasco D, Benedetti E, Ragone R, Rossi F
* Effect of salts on the structural behavior of hPrP α2-helix-derived analogues: The counterion perspective (454 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2006 Dec; 12(12): 790-795.
Impact Factor: 1.801
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Esposito L, Pedone C, Vitagliano L
* Molecular dynamics analyses of cross-beta-spine steric zipper models: beta-sheet twisting and aggregation (727 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2006 Sep 1; 103(31): 11533-11538.
Impact Factor: 9.643
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Ronga L, Tizzano B, Palladino P, Ragone R, Urso E, Maffia M, Ruvo M, Benedetti E, Rossi F
* The prion protein: structural features and related toxic peptides (529 views)
Chem Biol Drug Des (ISSN: 1747-0277, 1747-0285), 2006 Sep; 68(3): 139-147.
Impact Factor: 2.507
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Joszal V, Nagy Z, Osz K, Sanna D, Di Natale G, La Mendola D, Pappalardo G, Rizzarelli E, Sovago I
* Transition metal complexes of terminally protected peptides containing histidyl residues (513 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2006 Sep; 100(8): 1399-1409.
Impact Factor: 2.654
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Langella E, Improta R, Crescenzi O, Barone V
* Assessing the acid-base and conformational properties of histidine residues in human prion protein (125-228) by means of pKα calculations and molecular dynamics simulations (580 views)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2006 Jul 1; 64(1): 167-177.
Impact Factor: 3.73
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Granata V, Palladino P, Tizzano B, Negro A, Berisio R, Zagari A
* The effect of the osmolyte trimethylamine N-oxide on the stability of the prion protein at low pH (402 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2006 Jun 15; 82(3): 234-240.
Impact Factor: 2.48
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Palladino P, Ronga L, Tizzano B, Rossi F, Ragone R, Tancredi T, Saviano G, Facchiano A, Costantini S, Ruvo M, Benedetti E
* Prion protein misfolding: Conformational stability of the alpha 2-helix (289 views)
Understanding Biology Using Peptides, 2006; N/D: N/D-N/D.
Impact Factor: 2.614
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Grasso D, Grasso G, Guantieri V, Impellizzeri G, La Rosa C, Milardi D, Micera G, Osz K, Pappalardo G, Rizzarelli E, Sanna D, Sovago I
* Environmental effects on a prion's helix II domain: copper(II) and membrane interactions with PrP180-193 and its analogues (432 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2005 Dec 23; 12(2): 537-547.
Impact Factor: 4.907
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La Mendola D, Bonomo RP, Impellizzeri G, Maccarrone G, Pappalardo G, Pietropaolo A, Rizzarelli E, Zito V
* Copper(II) complexes with chicken prion repeats: Influence of proline and tyrosine residues on the coordination features (303 views)
J Biol Inorg Chem (ISSN: 0949-8257, 1432-1327electronic, 0949-8257print), 2005 Sep; 10(5): 463-475.
Impact Factor: 3.224
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Tizzano B, Palladino P, De Capua A, Marasco D, Rossi F, Benedetti E, Pedone C, Ragone R, Ruvo M
* The Human Prion Protein Alpha2 Helix: A Thermodynamic Study Of Its Conformational Preferences (504 views)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2005 Apr 1; 59(1): 72-79.
Impact Factor: 4.684
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Di Natale G, Impellizzeri G, Pappalardo G
* Conformational properties of peptide fragments homologous to the 106-114 and 106-126 residues of the human prion protein: a CD and NMR spectroscopic study (424 views)
Org Biomol Chem (ISSN: 1477-0520, 1477-0539, 1477-0539electronic), 2005 Feb 7; 3(3): 490-497.
Impact Factor: 2.547
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Bonomo RP, Cucinotta V, Giuffrida A, Impellizzeri G, Magrì A, Pappalardo G, Rizzarelli E, Santoro AM, Tabbì G, Vagliasindi LI
* A re-investigation of copper coordination in the octa-repeats region of the prion protein (376 views)
Dalton T (ISSN: 1477-9226, 1477-9234, 1477-9234electronic), 2005 Jan 7; (1): 150-158.
Impact Factor: 3.003
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Langella E, Improta R, Barone V
* Checking the pH-induced conformational transition of prion protein by molecular dynamics simulations: Effect of protonation of histidine residues (427 views)
Biophysical Journal (ISSN: 0006-3495, 1542-0086), 2004 Dec; 87(6): 3623-3632.
Impact Factor: 4.585
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Pappalardo M, Milardi D, La Rosa C, Zannoni C, Rizzarelli E, Grasso D
* A molecular dynamics study on the conformational stability of PrP 180-193 helix II prion fragment (306 views)
Chem Phys Lett (ISSN: 0009-2614), 2004 Jun 1; 390(4-6): 511-516.
Impact Factor: 2.438
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Grasso D, Milardi D, La Rosa C, Rizzarelli E
* The different role of Cu++ and Zn++ ions in affecting the interaction of prion peptide PrP106-126 with model membranes (283 views)
Chem Commun (ISSN: 1359-7345, 1364-548x, 1364-548xelectronic), 2004 Jan 21; 10(2): 246-247.
Impact Factor: 3.997
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Brown DR, Guantieri V, Grasso G, Impellizzeri G, Pappalardo G, Rizzarelli E
* Copper(II) complexes of peptide fragments of the prion protein. Conformation changes induced by copper(II) and the binding motif in C-terminal protein region (495 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2004 Jan; 98(1): 133-143.
Impact Factor: 2.225
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Barone V, Improta R, Rega N
* Computation of protein pK's values by an integrated density functional theory/Polarizable Continuum Model approach (288 views)
Theor Chem Acc (ISSN: 1432-881x), 2004; 111(2-6): 237-245.
Impact Factor: 2.209
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Tizzano B, Marasco D, Benedetti E, De Capua A, Palladino P, Pedone C, Perretta G, Rossi F, Ragone R, Ruvo M
* Conformational conversion of prion proteins: Role synthetic PRP 173-195 fibrillogenic peptide (354 views)
Peptide Revolution, 2004; N/D: N/D-N/D.
Impact Factor: 4.659
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Pappalardo G, Impellizzeri G, Campagna T
* Copper(II) binding of prion protein's octarepeat model peptides (505 views)
Inorg Chim Acta (ISSN: 0020-1693), 2004; 357(1): 185-194.
Impact Factor: 1.554
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La Mendola D, Bonomo R, Maccarrone G, Pappalardo G, Rizzarelli E
* A thermodynamic and spectroscopic study on the copper(II) complexes with hexarepeats fragments of the avian prion protein (324 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2003 Jul 15; 96(1): N/D-N/D.
Impact Factor: 2.343
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Bonomo RP, Grasso D, Grasso G, Guantieri V, Impellizzeri G, La Rosa C, Milardi D, Pappalardo G, Tabbì G, Rizzarelli E
* Metal binding to prion protein (269 views)
Metal-Ligand Interactions - Molecular Nano- Micro- And Macro-Systems In Complex Environments, 2003 Jan 01; 116: 21-39.
Impact Factor: 5.664
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Grasso D, Milardi D, Guantieri V, La Rosa C, Rizzarelli E
* Interaction of prion peptide PrP 180-193 with DPPC model membranes: A thermodynamic study (383 views)
New J Chem (ISSN: 1144-0546), 2003; 27(2): 359-364.
Impact Factor: 2.272
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Menziani MC, De Benedetti PG, Langella E, Barone V
* Seeking for binding determinants of the prion protein to human plasminogen (391 views)
Mol Phys (ISSN: 0026-8976), 2003; 101(17): 2763-2773.
Impact Factor: 1.591
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Grasso D, Milardi D, La Rosa C, Rizzarelli E
* DSC study of the interaction of the prion peptide PrP106-126 with artificial membranes (377 views)
New J Chem (ISSN: 1144-0546), 2001; 25(12): 1543-1548.
Impact Factor: 2.44
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Bonomo RP, Imperllizzeri G, Pappalardo G, Rizzarelli E, Tabbì G
Copper(II) binding modes in the prion octapeptide PHGGGWGQ: A spectroscopic and voltammetric study (502 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2000 Nov 17; 6(22): 4195-4202.
Impact Factor: 4.698
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* Corrigendum to "Engineered β-hairpin scaffolds from human prion protein regions: Structural and functional investigations of aggregates" [Bioorg. Chem. 96 (2020) 103594] (36 views)
Bioorg Chem (ISSN: 0045-2068linking, 1090-2120electronic), 2020 Jun; 99: 103853-103853.
Impact Factor: 3.119
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Di Natale C, La Manna S, Avitabile C, Florio D, Morelli G, Netti PA, Marasco D
* Engineered β-hairpin scaffolds from human prion protein regions: Structural and functional investigations of aggregates (58 views)
Bioorg Chem (ISSN: 0045-2068linking, 1090-2120electronic), 2020 Mar; 96: 103594-103594.
Impact Factor: 4.831
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Dell'Acqua S, Bacchella C, Monzani E, Nicolis S, Di Natale G, Rizzarelli E, Casella L
* Prion Peptides Are Extremely Sensitive to Copper Induced Oxidative Stress (583 views)
Inorg Chem (ISSN: 0020-1669, 1520-510x, 0020-1669linking), 2017 Sep 18; 56(18): 11317-11325.
Impact Factor: 4.7
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Di Natale G, Turi I, Pappalardo G, Sóvágó I, Rizzarelli E
* Cross-Talk Between the Octarepeat Domain and the Fifth Binding Site of Prion Protein Driven by the Interaction of Copper(II) with the N-terminus (454 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2015 Mar 2; 21(10): 4071-4084.
Impact Factor: 5.771
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Benetti F, Biarnés X, Attanasio F, Giachin G, Rizzarelli E, Legname G
* Structural determinants in prion protein folding and stability (596 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 0022-2836linking), 2014 Nov 11; 426(22): 3796-3810.
Impact Factor: 4.333
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La Mendola D, Rizzarelli E
* Evolutionary implications of metal binding features in different species' prion protein: an inorganic point of view (354 views)
Biomolecules (ISSN: 2218-273x), 2014 May 23; 4(2): 546-565.
Impact Factor: 2.095
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De Simonea A, Stanzione F, Marasco D, Vitagliano L, Esposito L
* The Intrinsic Stability Of The Human Prion Beta-Sheet Region Investigated By Molecular Dynamics (608 views)
Journal Of Biomolecular Structure & Dynamics, 2013 May 1; 31(5): 441-452.
Impact Factor: 2.983
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Jószai V, Turi I, Kállay C, Pappalardo G, Di Natale G, Rizzarelli E, Sóvágó I
* Mixed metal copper(II)-nickel(II) and copper(II)-zinc(II) complexes of multihistidine peptide fragments of human prion protein (481 views)
J Chem Res (ISSN: 1873-3344, 0162-0134, 0162-0134print), 2012 Jul; 112: 17-24.
Impact Factor: 3.197
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Benetti F, Biarnes X, Attanasio F, Rizzarelli E, Laio A, Legname G
* Description and Characterization of a Highly Stable Enthalpic Intermediate State in Mouse Prion Protein Folding (306 views)
Prion (ISSN: 1933-6896), 2011 Apr; 5: N/D-N/D.
Impact Factor: 2.85
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Kállay C, Turi I, Timári S, Nagy Z, Sanna D, Pappalardo G, De Bona P, Rizzarelli E, Sóvágó I
* The effect of point mutations on copper(II) complexes with peptide fragments encompassing the 106-114 region of human prion protein (503 views)
Monatshefte Fur Chemie (ISSN: 0026-9247), 2011 Apr; 142(4): 411-419.
Impact Factor: 1.532
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Vagliasindi LI, Arena G, Bonomo RP, Pappalardo G, Tabbì G
* Copper complex species within a fragment of the N-terminal repeat region in opossum PrP protein (357 views)
Dalton T (ISSN: 1477-9226, 1477-9234, 1477-9234electronic), 2011 Mar 21; 40(11): 2441-2450.
Impact Factor: 3.838
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Di Natale G, Pappalardo G, Milardi D, Sciacca MF, Attanasio F, La Mendola D, Rizzarelli E
* Membrane interactions and conformational preferences of human and avian prion N-terminal tandem repeats: The role of copper(II) ions, pH, and membrane mimicking environments (494 views)
J Phys Chem B (ISSN: 1520-6106, 1520-5207, 1520-5207electronic), 2010 Nov 4; 114(43): 13830-13838.
Impact Factor: 3.603
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Turi I, Kállay C, Szikszai D, Pappalardo G, Di Natale G, De Bona P, Rizzarelli E, Sóvágó I
* Nickel(II) complexes of the multihistidine peptide fragments of human prion protein (480 views)
J Chem Res (ISSN: 1873-3344, 0162-0134, 0162-0134print), 2010 Sep; 104(8): 885-891.
Impact Factor: 3.317
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Benetti F, Pastorino L, Attanasio F, Rizzarelli E, Legname G
* Insights into Prion Protein Stability (267 views)
Prion (ISSN: 1933-6896), 2010 Jul; 4(3): N/D-N/D.
Impact Factor: 2.468
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La Mendola D, Magrì A, Campagna T, Campitiello MA, Raiola L, Isernia C, Hansson O, Bonomo RP, Rizzarelli E
* A doppel alpha-helix peptide fragment mimics the copper(II) interactions with the whole protein (1115 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2010 Jun 1; 16(21): 6212-6223.
Impact Factor: 5.476
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Di Natale G, Pappalardo G, Milardi D, Sciacca MFM, Attanasio F, La Mendola D, Rizzarelli E
* Different Interactions Of Human And Avian Prion Proteins N-Terminal Tandem Repeat Peptides And Their Copper (ii) Complexes With Model Membranes (385 views)
Journal Of Chemical Physics, 2010; 114: 13830-13838.
Impact Factor: 2.028
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Palladino P, Ronga L, Benedetti E, Rossi F, Ragone R
* Peptide Fragment Approach to Prion Misfolding: The Alpha-2 Domain (401 views)
Int J Pept Res Ther (ISSN: 1573-3149, 0929-5666), 2009 Sep; 15(3): 165-176.
Impact Factor: 0.869
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Pietropaolo A, Muccioli L, Zannoni C, Rizzarelli E
* Conformational preferences of the full chicken prion protein in solution and its differences with respect to mammals (381 views)
Chemphyschem (ISSN: 1439-7641, 1439-4235, 1439-7641electronic), 2009 Jul 13; 10(9-10): 1500-1510.
Impact Factor: 3.453
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La Mendola D, Pietropaolo A, Pappalardo G, Zannoni C, Rizzarelli E
* Prion Proteins Leading to Neurodegeneration (vol 5, pg 579, 2008) (233 views)
Current Alzheimer Research (ISSN: 1567-2050), 2009 Jun; 6(3): N/D-N/D.
Impact Factor: 4.971
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Di Natale G, Osz K, Nagy Z, Sanna D, Micera G, Pappalardo G, Sovago I, Rizzarelli E
* The Interaction Of Copper (ii) With The Prion Peptide Fragment Huprp (76-114) Encompassing Four Histidyl Residues Within And Outside The Octarepeat Domain (323 views)
Inorg Chem (ISSN: 0020-1669, 1520-510x, 1520-510xelectronic), 2009 May 4; 48(9): 4239-4250.
Impact Factor: 4.657
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La Mendola D, Magrì A, Hansson O, Bonomo RP, Rizzarelli E
* Copper(II) complexes with peptide fragments encompassing the sequence 122-130 of human doppel protein (361 views)
Journal Of Inorganic Biochemistry, 2009 May; 103(5): 758-765.
Impact Factor: 3.444
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Bonomo RP, Di Natale G, Rizzarelli E, Tabbì G, Vagliasindi LI
* Copper(II) complexes of prion protein PEG11-tetraoctarepeat fragment: spectroscopic and voltammetric studies (411 views)
Dalton T (ISSN: 1477-9226, 1477-7922, 1477-9234), 2009 Apr 14; (14): 2637-2646.
Impact Factor: 2.908
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La Mendola D, Pietropaolo A, Pappalardo G, Zannoni C, Rizzarelli E
* Prion proteins leading to neurodegeneration (420 views)
Current Alzheimer Research (ISSN: 1567-2050), 2008 Dec; 5(6): 579-590.
Impact Factor: 4.132
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Bonomo RP, Pappalardo G, Rizzarelli E, Tabbì G, Vagliasindi LI
* Studies of nitric oxide interaction with mono- and dinuclear copper(II) complexes of prion protein bis-octarepeat fragments (309 views)
Dalton T (ISSN: 1477-9226, 1477-9234, 1477-9234electronic), 2008 Sep 7; (29): 3805-3816.
Impact Factor: 3.58
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Pietropaolo A, Muccioli L, Zannoni C, La Mendola D, Maccarrone G, Pappalardo G, Rizzarelli E
* Unveiling the role of histidine and tyrosine residues on the conformation of the avian prion hexarepeat domain (343 views)
J Phys Chem B (ISSN: 1520-6106, 1520-5207, 1520-5207electronic), 2008 Apr 24; 112(16): 5182-5188.
Impact Factor: 4.189
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De Simone A, Pedone C, Vitagliano L
* Structure, dynamics, and stability of assemblies of the human prion fragment SNQNNF (503 views)
Biochem Biophys Res Commun (ISSN: 1090-2104, 0006-291x, 1090-2104electronic), 2008 Feb 15; 366(3): 800-806.
Impact Factor: 2.648
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Ronga L, Palladino P, Saviano G, Tancredi T, Benedetti E, Ragone R, Rossi F
* Structural characterization of a neurotoxic threonine-rich peptide corresponding to the human prion protein α2-helical 180-195 segment and comparison with full-length α2-helix-derived peptides (411 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2008; 14(10): 1096-1102.
Impact Factor: 1.654
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Bonomo RP, Pappalardo G, Rizzarelli E, Santoro AM, Tabbì G, Vagliasindi LI
* Nitrogen oxide interaction with copper complexes formed by small peptides belonging to the prion protein octa-repeat region (562 views)
Dalton T (ISSN: 1477-9226, 1477-9234, 1477-9234electronic), 2007 Apr 14; (14): 1400-1408.
Impact Factor: 3.212
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Ronga L, Langella E, Palladino P, Marasco D, Tizzano B, Saviano M, Pedone C, Improta R, Ruvo M
* Does Tetracycline Bind Helix 2 Of Prion? An Integrated Spectroscopical And Computational Study Of The Interaction Between The Antibiotic And Alpha Helix 2 Human Prion Protein Fragments (512 views)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2007 Feb 15; 66(3): 707-715.
Impact Factor: 3.354
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Ronga L, Palladino P, Costantini S, Facchiano A, Ruvo M, Benedetti E, Ragone R, Rossi F
* Conformational diseases and structure-toxicity relationships: Lessons from prion-derived peptides (553 views)
Curr Protein Pept Sci (ISSN: 1389-2037, 1389-2037linking), 2007 Feb; 8(1): 83-90.
Impact Factor: 3.259
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Rao M, Russo F, Granata V, Berisio R, Zagari A, Gianfreda L
* Fate of prions in soil: Interaction of a recombinant ovine prion protein with synthetic humic-like mineral complexes (426 views)
Soil Biol Biochem (ISSN: 0038-0717), 2007 Feb; 39(2): 493-504.
Impact Factor: 2.58
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Osz K, Nagy Z, Pappalardo G, Di Natale G, Sanna D, Micera G, Rizzarelli E, Sóvágó I
* Copper(II) interaction with prion peptide fragments encompassing histidine residues within and outside the octarepeat domain: speciation, stability constants and binding details (549 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2007; 13(25): 7129-7143.
Impact Factor: 5.33
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Ronga L, Palladino P, Saviano G, Tancredi T, Benedetti E, Ragone R, Rossi F
* NMR structure and CD titration with metal cations of human prion α2-helix-related peptides (465 views)
Bioinorg Chem Appl (ISSN: 1565-3633), 2007; 2007: N/D-N/D.
Impact Factor: 0.978
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Pappalardo M, Milardi D, Grasso D, La Rosa C
* Steered molecular dynamics studies reveal different unfolding pathways of prions from mammalian and non-mammalian species (338 views)
New J Chem (ISSN: 1144-0546), 2007; 31(6): 901-905.
Impact Factor: 2.651
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Ronga L, Palladino P, Tizzano B, Marasco D, Benedetti E, Ragone R, Rossi F
* Effect of salts on the structural behavior of hPrP α2-helix-derived analogues: The counterion perspective (454 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2006 Dec; 12(12): 790-795.
Impact Factor: 1.801
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Esposito L, Pedone C, Vitagliano L
* Molecular dynamics analyses of cross-beta-spine steric zipper models: beta-sheet twisting and aggregation (727 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2006 Sep 1; 103(31): 11533-11538.
Impact Factor: 9.643
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Ronga L, Tizzano B, Palladino P, Ragone R, Urso E, Maffia M, Ruvo M, Benedetti E, Rossi F
* The prion protein: structural features and related toxic peptides (529 views)
Chem Biol Drug Des (ISSN: 1747-0277, 1747-0285), 2006 Sep; 68(3): 139-147.
Impact Factor: 2.507
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Joszal V, Nagy Z, Osz K, Sanna D, Di Natale G, La Mendola D, Pappalardo G, Rizzarelli E, Sovago I
* Transition metal complexes of terminally protected peptides containing histidyl residues (513 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2006 Sep; 100(8): 1399-1409.
Impact Factor: 2.654
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Langella E, Improta R, Crescenzi O, Barone V
* Assessing the acid-base and conformational properties of histidine residues in human prion protein (125-228) by means of pKα calculations and molecular dynamics simulations (580 views)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2006 Jul 1; 64(1): 167-177.
Impact Factor: 3.73
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Granata V, Palladino P, Tizzano B, Negro A, Berisio R, Zagari A
* The effect of the osmolyte trimethylamine N-oxide on the stability of the prion protein at low pH (402 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2006 Jun 15; 82(3): 234-240.
Impact Factor: 2.48
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Palladino P, Ronga L, Tizzano B, Rossi F, Ragone R, Tancredi T, Saviano G, Facchiano A, Costantini S, Ruvo M, Benedetti E
* Prion protein misfolding: Conformational stability of the alpha 2-helix (289 views)
Understanding Biology Using Peptides, 2006; N/D: N/D-N/D.
Impact Factor: 2.614
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Grasso D, Grasso G, Guantieri V, Impellizzeri G, La Rosa C, Milardi D, Micera G, Osz K, Pappalardo G, Rizzarelli E, Sanna D, Sovago I
* Environmental effects on a prion's helix II domain: copper(II) and membrane interactions with PrP180-193 and its analogues (432 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2005 Dec 23; 12(2): 537-547.
Impact Factor: 4.907
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La Mendola D, Bonomo RP, Impellizzeri G, Maccarrone G, Pappalardo G, Pietropaolo A, Rizzarelli E, Zito V
* Copper(II) complexes with chicken prion repeats: Influence of proline and tyrosine residues on the coordination features (303 views)
J Biol Inorg Chem (ISSN: 0949-8257, 1432-1327electronic, 0949-8257print), 2005 Sep; 10(5): 463-475.
Impact Factor: 3.224
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Tizzano B, Palladino P, De Capua A, Marasco D, Rossi F, Benedetti E, Pedone C, Ragone R, Ruvo M
* The Human Prion Protein Alpha2 Helix: A Thermodynamic Study Of Its Conformational Preferences (504 views)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2005 Apr 1; 59(1): 72-79.
Impact Factor: 4.684
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Di Natale G, Impellizzeri G, Pappalardo G
* Conformational properties of peptide fragments homologous to the 106-114 and 106-126 residues of the human prion protein: a CD and NMR spectroscopic study (424 views)
Org Biomol Chem (ISSN: 1477-0520, 1477-0539, 1477-0539electronic), 2005 Feb 7; 3(3): 490-497.
Impact Factor: 2.547
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Bonomo RP, Cucinotta V, Giuffrida A, Impellizzeri G, Magrì A, Pappalardo G, Rizzarelli E, Santoro AM, Tabbì G, Vagliasindi LI
* A re-investigation of copper coordination in the octa-repeats region of the prion protein (376 views)
Dalton T (ISSN: 1477-9226, 1477-9234, 1477-9234electronic), 2005 Jan 7; (1): 150-158.
Impact Factor: 3.003
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Langella E, Improta R, Barone V
* Checking the pH-induced conformational transition of prion protein by molecular dynamics simulations: Effect of protonation of histidine residues (427 views)
Biophysical Journal (ISSN: 0006-3495, 1542-0086), 2004 Dec; 87(6): 3623-3632.
Impact Factor: 4.585
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Pappalardo M, Milardi D, La Rosa C, Zannoni C, Rizzarelli E, Grasso D
* A molecular dynamics study on the conformational stability of PrP 180-193 helix II prion fragment (306 views)
Chem Phys Lett (ISSN: 0009-2614), 2004 Jun 1; 390(4-6): 511-516.
Impact Factor: 2.438
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Grasso D, Milardi D, La Rosa C, Rizzarelli E
* The different role of Cu++ and Zn++ ions in affecting the interaction of prion peptide PrP106-126 with model membranes (283 views)
Chem Commun (ISSN: 1359-7345, 1364-548x, 1364-548xelectronic), 2004 Jan 21; 10(2): 246-247.
Impact Factor: 3.997
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Brown DR, Guantieri V, Grasso G, Impellizzeri G, Pappalardo G, Rizzarelli E
* Copper(II) complexes of peptide fragments of the prion protein. Conformation changes induced by copper(II) and the binding motif in C-terminal protein region (495 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2004 Jan; 98(1): 133-143.
Impact Factor: 2.225
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Barone V, Improta R, Rega N
* Computation of protein pK's values by an integrated density functional theory/Polarizable Continuum Model approach (288 views)
Theor Chem Acc (ISSN: 1432-881x), 2004; 111(2-6): 237-245.
Impact Factor: 2.209
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Tizzano B, Marasco D, Benedetti E, De Capua A, Palladino P, Pedone C, Perretta G, Rossi F, Ragone R, Ruvo M
* Conformational conversion of prion proteins: Role synthetic PRP 173-195 fibrillogenic peptide (354 views)
Peptide Revolution, 2004; N/D: N/D-N/D.
Impact Factor: 4.659
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Pappalardo G, Impellizzeri G, Campagna T
* Copper(II) binding of prion protein's octarepeat model peptides (505 views)
Inorg Chim Acta (ISSN: 0020-1693), 2004; 357(1): 185-194.
Impact Factor: 1.554
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La Mendola D, Bonomo R, Maccarrone G, Pappalardo G, Rizzarelli E
* A thermodynamic and spectroscopic study on the copper(II) complexes with hexarepeats fragments of the avian prion protein (324 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2003 Jul 15; 96(1): N/D-N/D.
Impact Factor: 2.343
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Bonomo RP, Grasso D, Grasso G, Guantieri V, Impellizzeri G, La Rosa C, Milardi D, Pappalardo G, Tabbì G, Rizzarelli E
* Metal binding to prion protein (269 views)
Metal-Ligand Interactions - Molecular Nano- Micro- And Macro-Systems In Complex Environments, 2003 Jan 01; 116: 21-39.
Impact Factor: 5.664
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Grasso D, Milardi D, Guantieri V, La Rosa C, Rizzarelli E
* Interaction of prion peptide PrP 180-193 with DPPC model membranes: A thermodynamic study (383 views)
New J Chem (ISSN: 1144-0546), 2003; 27(2): 359-364.
Impact Factor: 2.272
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Menziani MC, De Benedetti PG, Langella E, Barone V
* Seeking for binding determinants of the prion protein to human plasminogen (391 views)
Mol Phys (ISSN: 0026-8976), 2003; 101(17): 2763-2773.
Impact Factor: 1.591
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Grasso D, Milardi D, La Rosa C, Rizzarelli E
* DSC study of the interaction of the prion peptide PrP106-126 with artificial membranes (377 views)
New J Chem (ISSN: 1144-0546), 2001; 25(12): 1543-1548.
Impact Factor: 2.44
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Bonomo RP, Imperllizzeri G, Pappalardo G, Rizzarelli E, Tabbì G
Copper(II) binding modes in the prion octapeptide PHGGGWGQ: A spectroscopic and voltammetric study (502 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2000 Nov 17; 6(22): 4195-4202.
Impact Factor: 4.698
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59 Records (52 excluding Abstracts).
Total impact factor: 198.479 (177.596 excluding Abstracts).
Total 5 year impact factor: 209.855 (186.998 excluding Abstracts).
Total impact factor: 198.479 (177.596 excluding Abstracts).
Total 5 year impact factor: 209.855 (186.998 excluding Abstracts).
286 views. Last view on Saturday 14 January 2023, 19:03:16
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