Bone mineral density in children, adolescents, and young adults with epilepsy(372 views) Coppola G, Fortunato D, Auricchio G, Mainolfi C, Operto FF, Signoriello G, Pascotto A, Salvatore M
Keywords: Antiepileptic Drugs, Bone Mineral Density, Osteopenia, Osteoporosis, Physical Activity, 25 Hydroxyvitamin D, Alkaline Phosphatase, Aminotransferase, Calcitonin, Carbamazepine, Creatinine, Etiracetam, Gamma Glutamyltransferase, Glucose, Lamotrigine, Osteocalcin, Oxcarbazepine, Parathyroid Hormone, Phenobarbital, Phosphorus, Protein, Topiramate, Transferrin, Urea, Valproic Acid, Vigabatrin, Adjuvant Therapy, Adolescent, Adult, Alkaline Phosphatase Blood Level, Aminotransferase Blood Level, Anticonvulsant Therapy, Article, Body Mass, Bone Density, Bone Metabolism, Calcitonin Blood Level, Calcium Blood Level, Cerebral Palsy, Child, Clinical Assessment, Combination Chemotherapy, Controlled Study, Creatinine Blood Level, Disease Association, Drug Blood Level, Dual Energy X Ray Absorptiometry, Erythrocyte Count, Female, Focal Epilepsy, Gait Disorder, Gamma Glutamyl Transferase Blood Level, Generalized Epilepsy, Glucose Blood Level, Hemiplegia, Human, Huntington Chorea, Iron Blood Level, Landau Kleffner Syndrome, Lumbar Spine, Major Clinical Study, Mental Deficiency, Mental Patient, Monotherapy, Myoclonus Epilepsy, Onset Age, Parathyroid Hormone Blood Level, Phosphate Blood Level, Population Research, Prepuberty, Preschool Child, Priority Journal, Protein Blood Level, Quadriplegia, Rett Syndrome, Seizure, Side Effect, Thrombocyte Count, Transferrin Blood Level, Treatment Duration, Urea Blood Level, Vitamin Blood Level, Wolf Hirschhorn Syndrome, Photon, Age Factors, Body Mass Index, Comorbidity, Lumbar Vertebrae, Mental Retardation, Motor Activity, Risk Factors, Young Adult,
Affiliations: *** IBB - CNR ***
Clinic of Child Neuropsychiatry, Second University of Naples, Italy. giangennaro.coppola@unina2.it
Department of Radiology, Federico II University, Naples, Italy
Department of Public Health, Second University of Naples, Italy
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Bone mineral density in children, adolescents, and young adults with epilepsy
PURPOSE: The aim of this study was to assess bone mineral density (BMD) in a large population of children, adolescents, and young adults with epilepsy alone or in association with cerebral palsy and/or mental retardation.; METHODS: Ninety-six patients were enrolled in the study. The group comprised 50 males and 46 females, aged between 3 and 25 years (mean age 11 years). The control group consisted of 63 healthy children and adolescents (23 males, 40 females), aged between 3 and 25 years (mean age 12.1 years). Patients underwent a dual-energy x-ray absorptiometry (DEXA) scan of the lumbar spine (L1-L4) and the z scores were calculated for each patient; the t score was considered for patients 18 years of age or older.; RESULTS: Abnormal BMD was found in 56 patients (58.3%), with values documenting osteopenia in 42 (75%) and osteoporosis in 14 (25%). A significant difference emerged between epileptic patients and the control group in BMD, z score, and body mass index (BMI) (p =
Bone mineral density in children, adolescents, and young adults with epilepsy