Keywords: Dopamine 1 Receptor, Cognition, Hormone, Memory, Neurology, Adult, Article, Brain Cortex, Controlled Study, Dopaminergic Transmission, Female, Functional Magnetic Resonance Imaging, Human, In Vivo Study, Mental Performance, Normal Human, Plasticity, Priority Journal, Receptor Binding, Training, Working Memory, Brain Mapping, Cerebral Cortex, Short-Term, Parietal Lobe, Prefrontal Cortex, Regression Analysis, Synaptic Transmission, Young Adult,
Affiliations: *** IBB - CNR ***
Department of Woman and Child Health, Stockholm Brain Institute, Karolinska Institutet, Stockholm, Sweden
Department of Clinical Neuroscience, Stockholm Brain Institute, Karolinska Institutet, Stockholm, Sweden
AstraZeneca Research and Development, Södertälje, Sweden
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The authors thank C. Halldin, K. Kolaas, G. Lei, J. Macoveanu, and members of the Karolinska Institutet PET center for assistance in the PET measurements. This work was supported by the Swedish Foundation for Strategic Research, Swedish Research Council, VINNOVA the Swedish Governmental Agency for Innovation Systems, and Knut and Alice Wallenberg FoundationUR - http://www.scopus.com/inward/record.url?eid=2-s2.0-59849106304&partnerID=40&md5=aa29489cc34151f2f005e3176259d96b
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Changes in cortical dopamine D1 receptor binding associated with cognitive training
Working memory is a key function for human cognition, dependent on adequate dopamine neurotransmission. Here we show that the training of working memory, which improves working memory capacity, is associated with changes in the density of cortical dopamine D1 receptors. Fourteen hours of training over 5 weeks was associated with changes in both prefrontal and parietal D1 binding potential. This plasticity of the dopamine D1 receptor system demonstrates a reciprocal interplay between mental activity and brain biochemistry in vivo.
Changes in cortical dopamine D1 receptor binding associated with cognitive training
No results.
Changes in cortical dopamine D1 receptor binding associated with cognitive training
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