Epigenetic modulation of mGlu2 receptors by histone deacetylase inhibitors in the treatment of inflammatory pain (497 views)
Mol Pharmacol (ISSN: 0026-895x), 2009; 75(5): 1014-1020.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 4.531, 5-year impact factor: 4.684
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-66049148780&partnerID=40&md5=9e959fc6841626f85140c45a88aa3c6a
Keywords: 2 Amino 2 (2 Carboxycyclopropyl) 3 (xanthen 9 Yl)propionic Acid, 4 Amino 2 Oxabicyclo[3 1 0]hexane 4, 6 Dicarboxylic Acid, Formaldehyde, Immunoglobulin Enhancer Binding Protein, Metabotropic Receptor 1, N (2 Aminophenyl) 4 (3 Pyridinylmethoxycarbonylaminomethyl)benzamide, Synaptotagmin I, Transcription Factor Rela, Unclassified Drug, Vorinostat, Acetylation, Analgesia, Analgesic Activity, Animal Experiment, Animal Model, Animal Tissue, Article, Controlled Study, Drug Antagonism, Drug Efficacy, Drug Receptor Binding, Drug Response, Epigenetics, Genetic Transcription, Human, Human Cell, Mouse, Nerve Cell, Nociception, Nonhuman, Pain, Persistent Inflammatory Pain, Priority Journal, Protein Expression, Receptor Upregulation, Sensitization, Single Drug Dose, Spinal Cord, Spinal Cord Dorsal Horn, Spinal Ganglion, Treatment Response, Amino Acids, Bicyclo Compounds, Heterocyclic, Enzyme Inhibitors, Epigenesis, Histone Deacetylase Inhibitors, Hydroxamic Acids, Inflammation, Metabotropic Glutamate, 2 Amino 2 (2 Carboxycyclopropyl) 3 (xanthen 9 Yl) Propionic Acid, 4 Amino 2 Oxabicyclo [3 1 0] Hexane 4, N (2 Aminophenyl) 4 (3 Pyridinylmethoxycarbonylaminomethyl) Benzamide,
Affiliations:
*** IBB - CNR ***
Department of Pharmaceutical Sciences, University of Catania, Italy
Department of Experimental and Clinical Pharmacology, University of Catania, Italy
Washington University Pain Center, Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO, United States
Department of Human Physiology and Pharmacology, University of Rome, La Sapienza, Italy
I.B.B., CNR-Catania, Italy
I.N.M. Neuromed., Pozzilli, Italy
I. B. B., CNR-Catania, Italy
I. N. M. Neuromed., Pozzilli, Italy
References:
Ashburner, B.P., Westerheide, S.D., Baldwin Jr., A.S., The p65 (RelA) subunit of NF-kappaB interacts with the histone deacetylase (HDAC) corepressors HDAC1 and HDAC2 to negatively regulate gene expression (2001) Molecular and Cellular Biology, 21 (20), pp. 7065-7077. , DOI 10.1128/MCB.21.20.7065-7077.200
Bi, J., Hu, X., Loh, H.H., Wei, L.-N., Regulation of mouse kappa opioid receptor gene expression by retinoids (2001) Journal of Neuroscience, 21 (5), pp. 1590-1599
Blanchard, F., Chipoy, C., Histone deacetylase inhibitors: New drugs for the treatment of inflammatory diseases? (2005) Drug Discovery Today, 10 (3), pp. 197-204. , DOI 10.1016/S1359-6446(04)03309-4, PII S1359644604033094
Bleakman, D., Alt, A., Nisenbaum, E.S., Glutamate receptors and pain (2006) Seminars in Cell and Developmental Biology, 17 (5), pp. 592-604. , DOI 10.1016/j.semcdb.2006.10.008, PII S1084952106001121, Pain
Buerki, C., Rothgiesser, K.M., Valovka, T., Owen, H.R., Rehrauer, H., Fey, M., Lane, W.S., Hottiger, M.O., Functional relevance of novel p300-mediated lysine 314 and 315 acetylation of RelA/p65 (2008) Nucleic Acids Res, 36, pp. 1665-1680
Carlton, S.M., Hargett, G.L., Coggeshall, R.E., Localization of metabotropic glutamate receptors 2/3 on primary afferent axons in the rat (2001) Neuroscience, 105 (4), pp. 957-969. , DOI 10.1016/S0306-4522(01)00238-X, PII S030645220100238X
Chen, L.-F., Fischle, W., Verdin, E., Greene, W.C., Duration of nuclear NF-kappaB action regulated by reversible acetylation (2001) Science, 293 (5535), pp. 1653-1657. , DOI 10.1126/science.1062374
Chen, L.F., Greene, W.C., Shaping the nuclear action of NF-kappaB (2004) Nat Rev Mol Cell Biol, 5, pp. 392-401
Chen, L.-F., Mu, Y., Greene, W.C., Acetylation of RelA at discrete sites regulates distinct nuclear functions of NF-kappaB (2002) EMBO Journal, 21 (23), pp. 6539-6548. , DOI 10.1093/emboj/cdf660
Chiechio, S., Caricasole, A., Barletta, E., Storto, M., Catania, M.V., Copani, A., Vertechy, M., Nicoletti, F., L-acetylcarnitine induces analgesia by selectively upregulating mGlu2 metabotropic glutamate receptors (2002) Molecular Pharmacology, 61 (5), pp. 989-996. , DOI 10.1124/mol.61.5.989
Chiechio, S., Copani, A., De Petris, L., Morales, M.E., Nicoletti, F., Gereau IV, R.W., Transcriptional regulation of metabotropic glutamate receptor 2/3 expression by the NF-kappaB pathway in primary dorsal root ganglia neurons: A possible mechanism for the analgesic effect of L-acetylcarnitine (2006) Mol Pain, 2, p. 20
Coderre, T.J., Contribution of protein kinase C to central sensitization and persistent pain following tissue injury (1992) Neurosci Lett, 140, pp. 181-184
Coderre, T.J., Melzack, R., The contribution of excitatory amino acids to central sensitization and persistent nociception after formalin-induced tissue injury (1992) J Neurosci, 12, pp. 3665-3670
Dai, Y., Rahmani, M., Dent, P., Grant, S., Blockade of histone deacetylase inhibitor-induced RelA/p65 acetylation and NF-kappaB activation potentiates apoptosis in leukemia cells through a process mediated by oxidative damage, XIAP downregulation, and c-Jun N-terminal kinase 1 activation (2005) Molecular and Cellular Biology, 25 (13), pp. 5429-5444. , DOI 10.1128/MCB.25.13.5429-5444.2005
Dougherty, P.M., Cata, J.P., Cordella, J.V., Burton, A., Weng, H.-R., Taxol-induced sensory disturbance is characterized by preferential impairment of myelinated fiber function in cancer patients (2004) Pain, 109 (1-2), pp. 132-142. , DOI 10.1016/j.pain.2004.01.021, PII S0304395904000533
Dunayevich, E., Erickson, J., Levine, L., Landbloom, R., Schoepp, D.D., Tollefson, G.D., Efficacy and tolerability of an mGlu2/3 agonist in the treatment of generalized anxiety disorder (2008) Neuropsychopharmacology, 33, pp. 1603-1610. , Published erratum appears in Neuropsychopharmacology 33:2549
Fundytus, M.E., Glutamate receptors and nociception: Implications for the drug treatment of pain (2001) CNS Drugs, 15 (1), pp. 29-58
Gerber, G., Zhong, J., Youn, D., Randic, M., Group II and group III metabotropic glutamate receptor agonists depress synaptic transmission in the rat spinal cord dorsal horn (2000) Neuroscience, 100, pp. 393-406
Gu, G., Lorrain, D.S., Wei, H., Cole, R.L., Zhang, X., Daggett, L.P., Schaffhauser, H.J., Lechner, S.M., Distribution of metabotropic glutamate 2 and 3 receptors in the rat forebrain: Implication in emotional responses and central disinhibition (2008) Brain Res, 1197, pp. 47-62
Hu, J., Colburn, N.H., Histone deacetylase inhibition down-regulates cyclin D1 transcription by inhibiting nuclear factor-kappaB/p65 DNA binding (2005) Molecular Cancer Research, 3 (2), pp. 100-109. , DOI 10.1158/1541-7786.MCR-04-0070
Iacovelli, L., Molinaro, G., Battaglia, G., Motolese, M., Di Menna, L., Alfiero, M., Blahos, J., Corti, C., Regulation of group II metabotropic glutamate receptors by G protein-coupled receptor kinases: MGlu2 receptors are resistant to homologous desensitization (2009) Mol Pharmacol, 75, pp. 991-1003
Jones, C.K., Eberle, E.L., Peters, S.C., Monn, J.A., Shannon, H.E., Analgesic effects of the selective group II (mGlu2/3) metabotropic glutamate receptor agonists LY379268 and LY389795 in persistent and inflammatory pain models after acute and repeated dosing (2005) Neuropharmacology, 49 (SUPPL.), pp. 206-218. , DOI 10.1016/j.neuropharm.2005.05.008, PII S0028390805001899
Khan, N., Jeffers, M., Kumar, S., Hackett, C., Boldog, F., Khramtsov, N., Qian, X., Carey, N., Determination of the class and isoform selectivity of small-molecule histone deacetylase inhibitors (2008) Biochem J, 409, pp. 581-589
Kiernan, R., Bres, V., Ng, R.W.M., Coudart, M.-P., El Messaoudi, S., Sardet, C., Jin, D.-Y., Benkirane, M., Post-activation turn-off of NF-kappaB-dependent transcription is regulated by acetylation of p65 (2003) Journal of Biological Chemistry, 278 (4), pp. 2758-2766. , DOI 10.1074/jbc.M209572200
Lin, Y.C., Flock, K.E., Cook, R.J., Hunkele, A.J., Loh, H.H., Ko, J.L., Effects of trichostatin a on neuronal mu-opioid receptor gene expression (2008) Brain Res, 1246, pp. 1-10
Malmberg, A.B., Gilbert, H., McCabe, R.T., Basbaum, A.I., Powerful antinociceptive effects of the cone snail venom-derived subtype-selective NMDA receptor antagonists conantokins G and T (2003) Pain, 101 (1-2), pp. 109-116. , DOI 10.1016/S0304-3959(02)00303-2
Minucci, S., Pelicci, P.G., Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer (2006) Nature Reviews Cancer, 6 (1), pp. 38-51. , DOI 10.1038/nrc1779
Neki, A., Ohishi, H., Kaneko, T., Shigemoto, R., Nakanishi, S., Mizuno, N., Pre- And postsynaptic localization of a metabotropic glutamate receptor, mGluR2, in the rat brain: An immunohistochemical study with a monoclonal antibody (1996) Neuroscience Letters, 202 (3), pp. 197-200. , DOI 10.1016/0304-3940(95)12248-6
Niederberger, E., Geisslinger, G., The IKK-NF-kappaB pathway: A source for novel molecular drug targets in pain therapy? (2008) FASEB J, 22, pp. 3432-3442
Patil, S.T., Zhang, L., Martenyi, F., Lowe, S.L., Jackson, K.A., Andreev, B.V., Avedisova, A.S., Schoepp, D.D., Activation of mGlu2/3 receptors as a new approach to treat schizophrenia: A randomized Phase 2 clinical trial (2007) Nature Medicine, 13 (9), pp. 1102-1107. , DOI 10.1038/nm1632, PII NM1632
Polomano, R.C., Mannes, A.J., Clark, U.S., Bennett, G.J., A painful peripheral neuropathy in the rat produced by the chemotherapeutic drug, paclitaxel (2001) Pain, 94 (3), pp. 293-304. , DOI 10.1016/S0304-3959(01)00363-3, PII S0304395901003633
Schoepp, D.D., Jane, D.E., Monn, J.A., Pharmacological agents acting at subtypes of metabotropic glutamate receptors (1999) Neuropharmacology, 38 (10), pp. 1431-1476. , DOI 10.1016/S0028-3908(99)00092-1, PII S0028390899000921
Simmons, R.M., Webster, A.A., Kalra, A.B., Iyengar, S., Group II mGluR receptor agonists are effective in persistent and neuropathic pain models in rats (2002) Pharmacol Biochem Behav, 73, pp. 419-427
Spange, S., Wagner, T., Heinzel, T., Krämer, O.H., Acetylation of non-histone proteins modulates cellular signalling at multiple levels (2009) Int J Biochem Cell Biol, 41, pp. 185-198
Strahl, B.D., Allis, C.D., The language of covalent histone modifications (2000) Nature, 403 (6765), pp. 41-45. , DOI 10.1038/47412
Tjølsen, A., Berge, O.G., Hunskaar, S., Rosland, J.H., Hole, K., The formalin test: An evaluation of the method (1992) Pain, 51, pp. 5-17
Xiao, W., Advances in NF-kappaB signaling transduction and transcription (2004) Cell Mol Immunol, 1, pp. 425-435
Xu, W.S., Parmigiani, R.B., Marks, P.A., Histone deacetylase inhibitors: Molecular mechanisms of action (2007) Oncogene, 26 (37), pp. 5541-5552. , DOI 10.1038/sj.onc.1210620, PII 1210620
Yang, D., Gereau IV, R.W., Peripheral group II metabotropic glutamate receptors (mGluR2/3) regulate prostaglandin e 2-mediated sensitization of capsaicin responses and thermal nociception (2002) Journal of Neuroscience, 22 (15), pp. 6388-6393
Yang, X.-J., Seto, E., HATs and HDACs: From structure, function and regulation to novel strategies for therapy and prevention (2007) Oncogene, 26 (37), pp. 5310-5318. , DOI 10.1038/sj.onc.1210599, PII 1210599
Ashburner, B. P., Westerheide, S. D., Baldwin Jr., A. S., The p65 (RelA) subunit of NF-kappaB interacts with the histone deacetylase (HDAC) corepressors HDAC1 and HDAC2 to negatively regulate gene expression (2001) Molecular and Cellular Biology, 21 (20), pp. 7065-7077. , DOI 10. 1128/MCB. 21. 20. 7065-7077. 200
Carlton, S. M., Hargett, G. L., Coggeshall, R. E., Localization of metabotropic glutamate receptors 2/3 on primary afferent axons in the rat (2001) Neuroscience, 105 (4), pp. 957-969. , DOI 10. 1016/S0306-4522 (01) 00238-X, PII S030645220100238X
Chen, L. -F., Fischle, W., Verdin, E., Greene, W. C., Duration of nuclear NF-kappaB action regulated by reversible acetylation (2001) Science, 293 (5535), pp. 1653-1657. , DOI 10. 1126/science. 1062374
Chen, L. F., Greene, W. C., Shaping the nuclear action of NF-kappaB (2004) Nat Rev Mol Cell Biol, 5, pp. 392-401
Chen, L. -F., Mu, Y., Greene, W. C., Acetylation of RelA at discrete sites regulates distinct nuclear functions of NF-kappaB (2002) EMBO Journal, 21 (23), pp. 6539-6548. , DOI 10. 1093/emboj/cdf660
Coderre, T. J., Contribution of protein kinase C to central sensitization and persistent pain following tissue injury (1992) Neurosci Lett, 140, pp. 181-184
Coderre, T. J., Melzack, R., The contribution of excitatory amino acids to central sensitization and persistent nociception after formalin-induced tissue injury (1992) J Neurosci, 12, pp. 3665-3670
Dougherty, P. M., Cata, J. P., Cordella, J. V., Burton, A., Weng, H. -R., Taxol-induced sensory disturbance is characterized by preferential impairment of myelinated fiber function in cancer patients (2004) Pain, 109 (1-2), pp. 132-142. , DOI 10. 1016/j. pain. 2004. 01. 021, PII S0304395904000533
Fundytus, M. E., Glutamate receptors and nociception: Implications for the drug treatment of pain (2001) CNS Drugs, 15 (1), pp. 29-58
Jones, C. K., Eberle, E. L., Peters, S. C., Monn, J. A., Shannon, H. E., Analgesic effects of the selective group II (mGlu2/3) metabotropic glutamate receptor agonists LY379268 and LY389795 in persistent and inflammatory pain models after acute and repeated dosing (2005) Neuropharmacology, 49 (SUPPL.), pp. 206-218. , DOI 10. 1016/j. neuropharm. 2005. 05. 008, PII S0028390805001899
Lin, Y. C., Flock, K. E., Cook, R. J., Hunkele, A. J., Loh, H. H., Ko, J. L., Effects of trichostatin a on neuronal mu-opioid receptor gene expression (2008) Brain Res, 1246, pp. 1-10
Malmberg, A. B., Gilbert, H., McCabe, R. T., Basbaum, A. I., Powerful antinociceptive effects of the cone snail venom-derived subtype-selective NMDA receptor antagonists conantokins G and T (2003) Pain, 101 (1-2), pp. 109-116. , DOI 10. 1016/S0304-3959 (02) 00303-2
Patil, S. T., Zhang, L., Martenyi, F., Lowe, S. L., Jackson, K. A., Andreev, B. V., Avedisova, A. S., Schoepp, D. D., Activation of mGlu2/3 receptors as a new approach to treat schizophrenia: A randomized Phase 2 clinical trial (2007) Nature Medicine, 13 (9), pp. 1102-1107. , DOI 10. 1038/nm1632, PII NM1632
Polomano, R. C., Mannes, A. J., Clark, U. S., Bennett, G. J., A painful peripheral neuropathy in the rat produced by the chemotherapeutic drug, paclitaxel (2001) Pain, 94 (3), pp. 293-304. , DOI 10. 1016/S0304-3959 (01) 00363-3, PII S0304395901003633
Schoepp, D. D., Jane, D. E., Monn, J. A., Pharmacological agents acting at subtypes of metabotropic glutamate receptors (1999) Neuropharmacology, 38 (10), pp. 1431-1476. , DOI 10. 1016/S0028-3908 (99) 00092-1, PII S0028390899000921
Simmons, R. M., Webster, A. A., Kalra, A. B., Iyengar, S., Group II mGluR receptor agonists are effective in persistent and neuropathic pain models in rats (2002) Pharmacol Biochem Behav, 73, pp. 419-427
Strahl, B. D., Allis, C. D., The language of covalent histone modifications (2000) Nature, 403 (6765), pp. 41-45. , DOI 10. 1038/47412
Tj lsen, A., Berge, O. G., Hunskaar, S., Rosland, J. H., Hole, K., The formalin test: An evaluation of the method (1992) Pain, 51, pp. 5-17
Xu, W. S., Parmigiani, R. B., Marks, P. A., Histone deacetylase inhibitors: Molecular mechanisms of action (2007) Oncogene, 26 (37), pp. 5541-5552. , DOI 10. 1038/sj. onc. 1210620, PII 1210620
Yang, X. -J., Seto, E., HATs and HDACs: From structure, function and regulation to novel strategies for therapy and prevention (2007) Oncogene, 26 (37), pp. 5310-5318. , DOI 10. 1038/sj. onc. 1210599, PII 1210599
Mol Pharmacol (ISSN: 0026-895x), 2009; 75(5): 1014-1020.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 4.531, 5-year impact factor: 4.684
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-66049148780&partnerID=40&md5=9e959fc6841626f85140c45a88aa3c6a
Keywords: 2 Amino 2 (2 Carboxycyclopropyl) 3 (xanthen 9 Yl)propionic Acid, 4 Amino 2 Oxabicyclo[3 1 0]hexane 4, 6 Dicarboxylic Acid, Formaldehyde, Immunoglobulin Enhancer Binding Protein, Metabotropic Receptor 1, N (2 Aminophenyl) 4 (3 Pyridinylmethoxycarbonylaminomethyl)benzamide, Synaptotagmin I, Transcription Factor Rela, Unclassified Drug, Vorinostat, Acetylation, Analgesia, Analgesic Activity, Animal Experiment, Animal Model, Animal Tissue, Article, Controlled Study, Drug Antagonism, Drug Efficacy, Drug Receptor Binding, Drug Response, Epigenetics, Genetic Transcription, Human, Human Cell, Mouse, Nerve Cell, Nociception, Nonhuman, Pain, Persistent Inflammatory Pain, Priority Journal, Protein Expression, Receptor Upregulation, Sensitization, Single Drug Dose, Spinal Cord, Spinal Cord Dorsal Horn, Spinal Ganglion, Treatment Response, Amino Acids, Bicyclo Compounds, Heterocyclic, Enzyme Inhibitors, Epigenesis, Histone Deacetylase Inhibitors, Hydroxamic Acids, Inflammation, Metabotropic Glutamate, 2 Amino 2 (2 Carboxycyclopropyl) 3 (xanthen 9 Yl) Propionic Acid, 4 Amino 2 Oxabicyclo [3 1 0] Hexane 4, N (2 Aminophenyl) 4 (3 Pyridinylmethoxycarbonylaminomethyl) Benzamide,
Affiliations:
*** IBB - CNR ***
Department of Pharmaceutical Sciences, University of Catania, Italy
Department of Experimental and Clinical Pharmacology, University of Catania, Italy
Washington University Pain Center, Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO, United States
Department of Human Physiology and Pharmacology, University of Rome, La Sapienza, Italy
I.B.B., CNR-Catania, Italy
I.N.M. Neuromed., Pozzilli, Italy
I. B. B., CNR-Catania, Italy
I. N. M. Neuromed., Pozzilli, Italy
References:
Ashburner, B.P., Westerheide, S.D., Baldwin Jr., A.S., The p65 (RelA) subunit of NF-kappaB interacts with the histone deacetylase (HDAC) corepressors HDAC1 and HDAC2 to negatively regulate gene expression (2001) Molecular and Cellular Biology, 21 (20), pp. 7065-7077. , DOI 10.1128/MCB.21.20.7065-7077.200
Bi, J., Hu, X., Loh, H.H., Wei, L.-N., Regulation of mouse kappa opioid receptor gene expression by retinoids (2001) Journal of Neuroscience, 21 (5), pp. 1590-1599
Blanchard, F., Chipoy, C., Histone deacetylase inhibitors: New drugs for the treatment of inflammatory diseases? (2005) Drug Discovery Today, 10 (3), pp. 197-204. , DOI 10.1016/S1359-6446(04)03309-4, PII S1359644604033094
Bleakman, D., Alt, A., Nisenbaum, E.S., Glutamate receptors and pain (2006) Seminars in Cell and Developmental Biology, 17 (5), pp. 592-604. , DOI 10.1016/j.semcdb.2006.10.008, PII S1084952106001121, Pain
Buerki, C., Rothgiesser, K.M., Valovka, T., Owen, H.R., Rehrauer, H., Fey, M., Lane, W.S., Hottiger, M.O., Functional relevance of novel p300-mediated lysine 314 and 315 acetylation of RelA/p65 (2008) Nucleic Acids Res, 36, pp. 1665-1680
Carlton, S.M., Hargett, G.L., Coggeshall, R.E., Localization of metabotropic glutamate receptors 2/3 on primary afferent axons in the rat (2001) Neuroscience, 105 (4), pp. 957-969. , DOI 10.1016/S0306-4522(01)00238-X, PII S030645220100238X
Chen, L.-F., Fischle, W., Verdin, E., Greene, W.C., Duration of nuclear NF-kappaB action regulated by reversible acetylation (2001) Science, 293 (5535), pp. 1653-1657. , DOI 10.1126/science.1062374
Chen, L.F., Greene, W.C., Shaping the nuclear action of NF-kappaB (2004) Nat Rev Mol Cell Biol, 5, pp. 392-401
Chen, L.-F., Mu, Y., Greene, W.C., Acetylation of RelA at discrete sites regulates distinct nuclear functions of NF-kappaB (2002) EMBO Journal, 21 (23), pp. 6539-6548. , DOI 10.1093/emboj/cdf660
Chiechio, S., Caricasole, A., Barletta, E., Storto, M., Catania, M.V., Copani, A., Vertechy, M., Nicoletti, F., L-acetylcarnitine induces analgesia by selectively upregulating mGlu2 metabotropic glutamate receptors (2002) Molecular Pharmacology, 61 (5), pp. 989-996. , DOI 10.1124/mol.61.5.989
Chiechio, S., Copani, A., De Petris, L., Morales, M.E., Nicoletti, F., Gereau IV, R.W., Transcriptional regulation of metabotropic glutamate receptor 2/3 expression by the NF-kappaB pathway in primary dorsal root ganglia neurons: A possible mechanism for the analgesic effect of L-acetylcarnitine (2006) Mol Pain, 2, p. 20
Coderre, T.J., Contribution of protein kinase C to central sensitization and persistent pain following tissue injury (1992) Neurosci Lett, 140, pp. 181-184
Coderre, T.J., Melzack, R., The contribution of excitatory amino acids to central sensitization and persistent nociception after formalin-induced tissue injury (1992) J Neurosci, 12, pp. 3665-3670
Dai, Y., Rahmani, M., Dent, P., Grant, S., Blockade of histone deacetylase inhibitor-induced RelA/p65 acetylation and NF-kappaB activation potentiates apoptosis in leukemia cells through a process mediated by oxidative damage, XIAP downregulation, and c-Jun N-terminal kinase 1 activation (2005) Molecular and Cellular Biology, 25 (13), pp. 5429-5444. , DOI 10.1128/MCB.25.13.5429-5444.2005
Dougherty, P.M., Cata, J.P., Cordella, J.V., Burton, A., Weng, H.-R., Taxol-induced sensory disturbance is characterized by preferential impairment of myelinated fiber function in cancer patients (2004) Pain, 109 (1-2), pp. 132-142. , DOI 10.1016/j.pain.2004.01.021, PII S0304395904000533
Dunayevich, E., Erickson, J., Levine, L., Landbloom, R., Schoepp, D.D., Tollefson, G.D., Efficacy and tolerability of an mGlu2/3 agonist in the treatment of generalized anxiety disorder (2008) Neuropsychopharmacology, 33, pp. 1603-1610. , Published erratum appears in Neuropsychopharmacology 33:2549
Fundytus, M.E., Glutamate receptors and nociception: Implications for the drug treatment of pain (2001) CNS Drugs, 15 (1), pp. 29-58
Gerber, G., Zhong, J., Youn, D., Randic, M., Group II and group III metabotropic glutamate receptor agonists depress synaptic transmission in the rat spinal cord dorsal horn (2000) Neuroscience, 100, pp. 393-406
Gu, G., Lorrain, D.S., Wei, H., Cole, R.L., Zhang, X., Daggett, L.P., Schaffhauser, H.J., Lechner, S.M., Distribution of metabotropic glutamate 2 and 3 receptors in the rat forebrain: Implication in emotional responses and central disinhibition (2008) Brain Res, 1197, pp. 47-62
Hu, J., Colburn, N.H., Histone deacetylase inhibition down-regulates cyclin D1 transcription by inhibiting nuclear factor-kappaB/p65 DNA binding (2005) Molecular Cancer Research, 3 (2), pp. 100-109. , DOI 10.1158/1541-7786.MCR-04-0070
Iacovelli, L., Molinaro, G., Battaglia, G., Motolese, M., Di Menna, L., Alfiero, M., Blahos, J., Corti, C., Regulation of group II metabotropic glutamate receptors by G protein-coupled receptor kinases: MGlu2 receptors are resistant to homologous desensitization (2009) Mol Pharmacol, 75, pp. 991-1003
Jones, C.K., Eberle, E.L., Peters, S.C., Monn, J.A., Shannon, H.E., Analgesic effects of the selective group II (mGlu2/3) metabotropic glutamate receptor agonists LY379268 and LY389795 in persistent and inflammatory pain models after acute and repeated dosing (2005) Neuropharmacology, 49 (SUPPL.), pp. 206-218. , DOI 10.1016/j.neuropharm.2005.05.008, PII S0028390805001899
Khan, N., Jeffers, M., Kumar, S., Hackett, C., Boldog, F., Khramtsov, N., Qian, X., Carey, N., Determination of the class and isoform selectivity of small-molecule histone deacetylase inhibitors (2008) Biochem J, 409, pp. 581-589
Kiernan, R., Bres, V., Ng, R.W.M., Coudart, M.-P., El Messaoudi, S., Sardet, C., Jin, D.-Y., Benkirane, M., Post-activation turn-off of NF-kappaB-dependent transcription is regulated by acetylation of p65 (2003) Journal of Biological Chemistry, 278 (4), pp. 2758-2766. , DOI 10.1074/jbc.M209572200
Lin, Y.C., Flock, K.E., Cook, R.J., Hunkele, A.J., Loh, H.H., Ko, J.L., Effects of trichostatin a on neuronal mu-opioid receptor gene expression (2008) Brain Res, 1246, pp. 1-10
Malmberg, A.B., Gilbert, H., McCabe, R.T., Basbaum, A.I., Powerful antinociceptive effects of the cone snail venom-derived subtype-selective NMDA receptor antagonists conantokins G and T (2003) Pain, 101 (1-2), pp. 109-116. , DOI 10.1016/S0304-3959(02)00303-2
Minucci, S., Pelicci, P.G., Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer (2006) Nature Reviews Cancer, 6 (1), pp. 38-51. , DOI 10.1038/nrc1779
Neki, A., Ohishi, H., Kaneko, T., Shigemoto, R., Nakanishi, S., Mizuno, N., Pre- And postsynaptic localization of a metabotropic glutamate receptor, mGluR2, in the rat brain: An immunohistochemical study with a monoclonal antibody (1996) Neuroscience Letters, 202 (3), pp. 197-200. , DOI 10.1016/0304-3940(95)12248-6
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Epigenetic modulation of mGlu2 receptors by histone deacetylase inhibitors in the treatment of inflammatory pain
Knowing that expression of metabotropic glutamate 2 (mGlu2) receptors in the dorsal root ganglia is regulated by acetylation mechanisms, we examined the effect of two selective and chemically unrelated histone deacetylase (HDAC) inhibitors, N-(2-aminophenyl)-4-[N-(pyridine-3-ylmethoxy-carbonyl)aminomethyl] benzamide (MS-275) and suberoylanilide hydroamic acid (SAHA), in a mouse model of persistent inflammatory pain. Although a single subcutaneous injection of MS-275 (3 mg/kg) or SAHA (5-50 mg/kg) was ineffective, a 5-day treatment with either of the two HDAC inhibitors substantially reduced the nociceptive response in the second phase of the formalin test, which reflects the development of central sensitization in the dorsal horn of the spinal cord. Analgesia was abrogated by a single injection of the mGlu2/3 receptor antagonist (αS)-α-amino-α-[(1S,2S)-2-carboxycyclopropyl] -9H-xantine-9-propanoic acid (LY341495; 1 mg/kg, i.p.), which was inactive per se. Both MS-275 and SAHA up-regulated the expression of mGlu2 receptors in the dorsal root ganglion (DRG) and spinal cord under conditions in which they caused analgesia, without changing the expression of mGlu1a, mGlu4, or mGlu5 receptors. Induction of DRG mGlu2 receptors in response to SAHA was associated with increased acetylation of p65/RelA on lysine 310, a process that enhances the transcriptional activity of p65/RelA at nuclear factor-κB-regulated genes. Transcription of the mGlu2 receptor gene is known to be activated by p65/RelA in DRG neurons. We conclude that HDAC inhibition produces analgesia by up-regulating mGlu2 receptor expression in the DRG, an effect that results from the amplification of NF-κB transcriptional activity. These data provide the first evidence that HDAC inhibitors cause analgesia and suggest that HDACs are potential targets for the epigenetic treatment of pain. Copyright © 2009 The American Society for Pharmacology and Experimental Therapeutics.
Knowing that expression of metabotropic glutamate 2 (mGlu2) receptors in the dorsal root ganglia is regulated by acetylation mechanisms, we examined the effect of two selective and chemically unrelated histone deacetylase (HDAC) inhibitors, N-(2-aminophenyl)-4-[N-(pyridine-3-ylmethoxy-carbonyl)aminomethyl] benzamide (MS-275) and suberoylanilide hydroamic acid (SAHA), in a mouse model of persistent inflammatory pain. Although a single subcutaneous injection of MS-275 (3 mg/kg) or SAHA (5-50 mg/kg) was ineffective, a 5-day treatment with either of the two HDAC inhibitors substantially reduced the nociceptive response in the second phase of the formalin test, which reflects the development of central sensitization in the dorsal horn of the spinal cord. Analgesia was abrogated by a single injection of the mGlu2/3 receptor antagonist (αS)-α-amino-α-[(1S,2S)-2-carboxycyclopropyl] -9H-xantine-9-propanoic acid (LY341495; 1 mg/kg, i.p.), which was inactive per se. Both MS-275 and SAHA up-regulated the expression of mGlu2 receptors in the dorsal root ganglion (DRG) and spinal cord under conditions in which they caused analgesia, without changing the expression of mGlu1a, mGlu4, or mGlu5 receptors. Induction of DRG mGlu2 receptors in response to SAHA was associated with increased acetylation of p65/RelA on lysine 310, a process that enhances the transcriptional activity of p65/RelA at nuclear factor-κB-regulated genes. Transcription of the mGlu2 receptor gene is known to be activated by p65/RelA in DRG neurons. We conclude that HDAC inhibition produces analgesia by up-regulating mGlu2 receptor expression in the DRG, an effect that results from the amplification of NF-κB transcriptional activity. These data provide the first evidence that HDAC inhibitors cause analgesia and suggest that HDACs are potential targets for the epigenetic treatment of pain. Copyright © 2009 The American Society for Pharmacology and Experimental Therapeutics.
Epigenetic modulation of mGlu2 receptors by histone deacetylase inhibitors in the treatment of inflammatory pain
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Epigenetic modulation of mGlu2 receptors by histone deacetylase inhibitors in the treatment of inflammatory pain
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Computational procedures to explain the different biological activity of DNA/DNA, DNA/PNA and PNA/PNA hybrid molecules mimicking NF-κB binding sites (493 views)
J Biomol Struct Dyn (ISSN: 0739-1102, 1538-0254electronic, 0739-1102linking), 2000 Dec; 18(3): 353-362.
Impact Factor: 1.826
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* Functional partnership between mGlu3 and mGlu5 metabotropic glutamate receptors in the central nervous system (396 views)
Neuropharm (ISSN: 0028-3908linking, 1873-7064electronic), 2018 Jan; 128: 301-313.
Impact Factor: 3.383
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Caraci F, Nicoletti F, Copani A
* Metabotropic glutamate receptors: the potential for therapeutic applications in Alzheimer's disease (538 views)
Curr Opin Pharmacol (ISSN: 1471-4892), 2017 Dec 23; 38: 1-7.
Impact Factor: 6.313
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Tornatore L, Sandomenico A, Raimondo D, Low C, Rocci A, Tralau-Stewart C, Capece D, D'Andrea D, Bua M, Boyle E, van Duin M, Zoppoli P, Jaxa-Chamiec A, Thotakura AK, Dyson J, Walker BA, Leonardi A, Chambery A, Driessen C, Sonneveld P, Morgan G, Palumbo A, Tramontano A, Rahemtulla A, Ruvo M, Franzoso G
* Cancer-selective targeting of the NF-kappaB survival pathway with GADD45beta/MKK7 inhibitors (623 views)
Cancer Cell (ISSN: 1535-6108), 2014 Oct 13; 26(4): 495-508.
Impact Factor: 23.523
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Sorriento D, Fusco A, Ciccarelli M, Rungi A, Anastasio A, Carillo A, Dorn II GW, Trimarco B, Iaccarino G
* Mitochondrial G protein coupled receptor kinase 2 regulates proinflammatory responses in macrophages (385 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 2013; 587(21): 3487-3494.
Impact Factor: 3.341
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Galdiero S, Falanga A, Cantisani M, Tarallo R, della Pepa ME, D'Oriano V, Galdiero M
* Microbe-Host Interactions: Structure and Role of Gram-Negative Bacterial Porins (629 views)
Curr Protein Pept Sci (ISSN: 1389-2037, 1389-2037linking), 2012 Dec; 13(8): 843-854.
Impact Factor: 2.326
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Caraci F, Battaglia G, Sortino MA, Spampinato S, Molinaro G, Copani A, Nicoletti F, Bruno V
* Metabotropic glutamate receptors in neurodegeneration/neuroprotection: Still a hot topic? (627 views)
Neurochem Int (ISSN: 0197-0186), 2012 Sep; 61(4): 559-565.
Impact Factor: 2.659
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Calabrese V, Cornelius C, Dinkova-Kostova AT, Iavicoli I, Di Paola R, Koverech A, Cuzzocrea S, Rizzarelli E, Calabrese EJ
* Cellular stress responses, hormetic phytochemicals and vitagenes in aging and longevity (3606 views)
Bba-Gen Subjects (ISSN: 0006-3002, 0925-4439, 1570-9639), 2012 May; 1822(5): 753-783.
Impact Factor: 3.733
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Caraci F, Spampinato S, Sortino MA, Bosco P, Battaglia G, Bruno V, Drago F, Nicoletti F, Copani A
* Dysfunction of TGF-β1 signaling in Alzheimer's disease: Perspectives for neuroprotection (987 views)
Cell Tissue Res (ISSN: 0302-766x), 2012 Jan; 347(1): 291-301.
Impact Factor: 3.677
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Vitiello M, Galdiero M, Finamore E, Galdiero S, Galdiero M
* NF-κB as a potential therapeutic target in microbial diseases (485 views)
Mol Biosyst (ISSN: 1742-206x), 2012; 8(4): 1108-1120.
Impact Factor: 3.35
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Cantisani M, Vitiello M, Falanga A, Finamore E, Galdiero M, Galdiero S
* Peptides complementary to the active loop of porin P2 from Haemophilus influenzae modulate its activity (510 views)
Int J Nanomed (ISSN: 1178-2013, 1176-9114, 1178-2013electronic), 2012; 7: 2361-2371.
Impact Factor: 3.463
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Palmieri G, Bergamo P, Luini A, Ruvo M, Gogliettino M, Langella E, Saviano M, Hegde RN, Sandomenico A, Rossi M
* Acylpeptide hydrolase inhibition as targeted strategy to induce proteasomal down-regulation (490 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2011 Oct 10; 6(10): e25888-e25888.
Impact Factor: 4.092
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Calabrese V, Cornelius C, Cuzzocrea S, Iavicoli I, Rizzarelli E, Calabrese EJ
* Hormesis, cellular stress response and vitagenes as critical determinants in aging and longevity (881 views)
Molecular Aspects Of Medicine (ISSN: 1872-9452, 0098-2997), 2011 Sep; 32(4-6): 279-304.
Impact Factor: 9.97
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Janda E, Palmieri C, Pisano A, Pontoriero M, Iaccino E, Falcone C, Fiume G, Gaspari M, Nevolo M, Di Salle E, Rossi A, De Laurentiis A, Greco A, Di Napoli D, Verheij E, Britti D, Lavecchia L, Quinto I, Scala G
* Btk regulation in human and mouse B cells via protein kinase C phosphorylation of IBtkγ (451 views)
Blood (ISSN: 0006-4971, 0006-6497, 0390-6078), 2011 Jun 16; 117(24): 6520-6531.
Impact Factor: 9.898
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Caraci F, Molinaro G, Battaglia G, Giuffrida ML, Riozzi B, Traficante A, Bruno V, Cannella M, Merlo S, Wang X, Heinz BA, Nisenbaum ES, Britton TC, Drago F, Sortino MA, Copani A, Nicoletti F
* Targeting group II Metabotropic Glutamate (mGlu) receptors for the treatment of psychosis associated with alzheimer's disease: Selective activation of mGlu2 receptors amplifies β-amyloid toxicity in cultured neurons, whereas dual activation of mGlu2 and mGlu3 receptors is neuroprotective (748 views)
Mol Pharmacol (ISSN: 0026-895x), 2011 Mar; 79(3): 618-626.
Impact Factor: 4.883
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Ciccarelli M, Sorriento D, Cipolletta E, Santulli G, Fusco A, Zhou R-H, Eckhart AD, Peppel K, Koch WJ, Trimarco B, Iaccarino G
* Impaired neoangiogenesis in β2-adrenoceptor gene-deficient mice: Restoration by intravascular human β2-adrenoceptor gene transfer and role of NFkB and CREB transcription factors (368 views)
Br J Pharmacol British Journal Of Pharmacology (ISSN: 0007-1188), 2011; 162(3): 712-721.
Impact Factor: 4.409
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Alterio V, Aurilia V, Romanelli A, Parracino A, Saviano M, D'Auria S, De Simone G
* Crystal structure of an S-formylglutathione hydrolase from pseudoalteromonas haloplanktis TAC125 (370 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2010 Sep; 93(8): 669-677.
Impact Factor: 2.572
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Romano S, D'Angelillo A, Pacelli R, Staibano S, De Luna E, Bisogni R, Eskelinen EL, Mascolo M, Calì G, Arra C, Romano M
* Role of FK506-binding protein 51 in the control of apoptosis of irradiated melanoma cells (449 views)
Cell Death Differ (ISSN: 1350-9047, 1476-5403electronic, 1350-9047linking), 2010 Jan; 17(1): 145-157.
Impact Factor: 9.05
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Sorriento D, Santulli G, Fusco A, Anastasio A, Trimarco B, Iaccarino G
* Intracardiac injection of AdGRK5-NT reduces left ventricular hypertrophy by inhibiting NF-κB-Dependent hypertrophic gene expression (502 views)
Hypertensionhypertension (ISSN: 0194-911x), 2010; 56(4): 696-704.
Impact Factor: 6.908
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Sorriento D, Iaccarino G, Trimarco B
The role of the transcription factor nuclear factor kappa B in the regulation of cardiac hypertrophy (410 views)
High Blood Press Cardiovasc Prev High Blood Pressure And Cardiovascular Prevention (ISSN: 1120-9879), 2010; 17(4): 209-217.
Impact Factor: 0
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Vitiello M, Finamore E, Falanga A, Raieta K, Cantisani M, Galdiero F, Pedone C, Galdiero M, Galdiero S
* Viral fusion peptides induce several signal transduction pathway activations that are essential for interleukin-10 and beta-interferon production (476 views)
Intervirology (ISSN: 1423-0100, 0300-5526), 2010; 53(6): 381-389.
Impact Factor: 1.756
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Marasco D, Stilo R, Sandomenico A, Monti SM, Tizzano B, De Capua A, Varricchio E, Liguoro D, Zotti T, Formisano S, Ruvo M, Vito P
* Generation And Functional Characterization Of A Bcl10-Inhibitory Peptide That Represses Nf-Kappa B Activation (506 views)
Biochem J (ISSN: 0264-6021, 1470-8728electronic, 0264-6021linking), 2009 Sep 15; 422(3): 553-561.
Impact Factor: 5.155
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Sandomenico A, Monti SM, Sabatella M, De Capua A, Tornatore L, Doti N, Viparelli F, Dathan NA, Pedone C, Ruvo M, Marasco D
* Protein-protein interactions: a simple strategy to identify binding sites and peptide antagonists (573 views)
Chem Biol Drug Des (ISSN: 1747-0285, 1747-0277), 2009 May; 73(5): 483-493.
Impact Factor: 2.473
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Sorriento D, Campanile A, Santulli G, Leggiero E, Pastore L, Trimarco B, Iaccarino G
* A new synthetic protein, TAT-RH, inhibits tumor growth through the regulation of NFκB activity (358 views)
Mol Cancermolecular Cancer (ISSN: 1476-4598), 2009; 8: N/D-N/D.
Impact Factor: 4.16
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Calabrese V, Cornelius C, Mancuso C, Pennisi G, Calafato S, Bellia F, Bates TE, Giuffrida Stella AM, Schapira T, Dinkova Kostova AT, Rizzarelli E
* Cellular stress response: a novel target for chemoprevention and nutritional neuroprotection in aging, neurodegenerative disorders and longevity (1232 views)
Neurochemical Research (ISSN: 1573-6903, 0364-3190), 2008 Dec; 33(12): 2444-2471.
Impact Factor: 2.26
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Sorriento D, Ciccarelli M, Santulli G, Campanile A, Altobelli GG, Cimini V, Galasso G, Astone D, Piscione F, Pastore L, Trimarco B, Iaccarino G
* The G-protein-coupled receptor kinase 5 inhibits NFκB transcriptional activity by inducing nuclear accumulation of IκBα (438 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2008; 105(46): 17818-17823.
Impact Factor: 9.38
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Improta R, Scalmani G, Frisch MJ, Barone V
* Toward effective and reliable fluorescence energies in solution by a new state specific polarizable continuum model time dependent density functional theory approach (459 views)
J Chem Phys (ISSN: 0021-9606, 0897-690online), 2007 Sep 21; 127(7): N/D-N/D.
Impact Factor: 3.044
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Improta R, Barone V, Scalmani G, Frisch MJ
* A state-specific polarizable continuum model time dependent density functional theory method for excited state calculations in solution (332 views)
J Chem Phys (ISSN: 0021-9606, 0897-690online), 2006 Sep 7; 125(5): N/D-N/D.
Impact Factor: 3.166
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Borgatti M, Finotti A, Romanelli A, Saviano M, Bianchi N, Lampronti I, Lambertini E, Penolazzi L, Nastruzzi C, Mischiati C, Piva R, Pedone C, Gambari R
* Peptide nucleic acids (PNA)-DNA chimeras targeting transcription factors as a tool to modify gene expression (478 views)
Curr Drug Targets (ISSN: 1389-4501), 2004 Nov; 5(8): 735-744.
Impact Factor: 4.104
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Mischiati C, Sereni A, Finotti A, Breda L, Cortesi R, Nastruzzi C, Romanelli A, Saviano M, Bianchi N, Pedone C, Borgatti M, Gambari R
* Complexation to cationic microspheres of double-stranded peptide nucleic acid-DNA chimeras exhibiting decoy activity (361 views)
Journal Of Biomedical Science (ISSN: 1021-7770), 2004 Sep; 11(5): 697-704.
Impact Factor: 1.567
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Penolazzi L, Borgatti M, Lambertini E, Mischiati C, Finotti A, Romanelli A, Saviano M, Pedone C, Piva R, Gambari R
* Peptide nucleic acid-DNA decoy chimeras targeting NF-kappa B transcription factors: Induction of apoptosis in human primary osteoclasts (312 views)
International Journal Of Molecular Medicine (ISSN: 1107-3756), 2004 Sep; 14(2): 145-152.
Impact Factor: 3.19
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Galdiero M, Vitiello M, Galdiero S
* Eukaryotic cell signaling and transcriptional activation induced by bacterial porins (491 views)
Fems Microbiology Letters (ISSN: 0378-1097), 2003 Sep 12; 226(1): 57-64.
Impact Factor: 1.932
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Borgatti M, Romanelli A, Saviano M, Pedone C, Lampronti I, Breda L, Nastruzzi C, Bianchi N, Mischiati C, Gambari R
* Resistance of decoy PNA-DNA chimeras to enzymatic degradation in cellular extracts and serum (372 views)
Oncology Research (ISSN: 0965-0407), 2003; 13(5): 279-287.
Impact Factor: 1.794
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Borgatti M, Breda L, Cortesi R, Nastruzzi C, Romanelli A, Saviano M, Bianchi N, Mischiati C, Pedone C, Gambari R
* Cationic Liposomes As Delivery Systems For Double-Stranded Pna-Dna Chimeras Exhibiting Decoy Activity Against Nf-Kappab Transcription Factors (416 views)
Biochem Pharmacol Biochemical Pharmacology (ISSN: 1873-2968, 0006-2952), 2002 Sep 15; 64(4): 609-616.
Impact Factor: 3.542
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Romanelli A, Pedone C, Saviano M, Bianchi N, Borgatti M, Mischiati C, Gambari R
* Molecular interactions between nuclear factor κB (NF-κB) transcription factors and a PNA-DNA chimera mimicking NF-κB binding sites (431 views)
Eur J Biochem (ISSN: 0014-2956, 0014-2956print, 0014-2956linking), 2001 Dec; 268(23): 6066-6075.
Impact Factor: 2.849
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Vitiello M, Finamore E, Falanga A, Raieta K, Cantisani M, Galdiero F, Pedone C, Galdiero M, Galdiero S
* Fusion in Coq (479 views)
Lecture Notes In Computer Science (ISSN: 0302-9743, 0302-974335404636319783540463634, 0302-974335402975459783540297543), 2001; 2178LNCS: 583-596.
Impact Factor: 0.415
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Saviano M, Romanelli A, Bucci E, Pedone C, Mischiati C, Bianchi N, Feriotto G, Borgatti M, Gambari R
Computational procedures to explain the different biological activity of DNA/DNA, DNA/PNA and PNA/PNA hybrid molecules mimicking NF-κB binding sites (493 views)
J Biomol Struct Dyn (ISSN: 0739-1102, 1538-0254electronic, 0739-1102linking), 2000 Dec; 18(3): 353-362.
Impact Factor: 1.826
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36 Records (34 excluding Abstracts).
Total impact factor: 160.163 (153.953 excluding Abstracts).
Total 5 year impact factor: 167.92 (161.735 excluding Abstracts).
Total impact factor: 160.163 (153.953 excluding Abstracts).
Total 5 year impact factor: 167.92 (161.735 excluding Abstracts).
497 views. Last view on Monday 27 March 2023, 9:54:00
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