First archaeal PEPB-serine protease inhibitor from sulfolobus solfataricus with noncanonical amino acid sequence in the reactive-site loop (399 views)
J Proteome Res (ISSN: 1535-3893), 2009 Jan; 8(1): 327-334.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 5.132, 5-year impact factor: 5.359
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-60849083258&partnerID=40&md5=ad3f5a0a11742f59cc991e34f30a01c7
Keywords: Homology Modeling, Pebp, Protease Binding Site, Protease Inhibitor Family, Serine Protease Inhibitor, Sulfolobus Solfataricus, Anion, Bacterial Protein, Chymotrypsin A, Elastase, Gene Product, Monomer, Phosphatidylethanolamine Binding Protein, Protein Sscei, Protein Sso0767, Serine Proteinase Inhibitor, Unclassified Drug, Alpha-Chymotrypsin, Amino Acid Sequence, Article, Carboxy Terminal Sequence, Drug Isolation, Drug Structure, Enzyme Active Site, Gene Inactivation, Inhibition Kinetics, Molecular Cloning, Molecular Weight, Nonhuman, Point Mutation, Prediction, Priority Journal, Protein Degradation, Protein Family, Protein Folding, Protein Motif, Protein Structure, Sequence Homology, Surface Property, Archaebacterium, Chemistry, Conformation, Escherichia Coli, Mass Spectrometry, Metabolism, Methodology, Molecular Genetics, Proteomics, Murinae, Catalytic Domain, Molecular Conformation, Molecular Sequence Data, Serine Endopeptidases,
Affiliations:
*** IBB - CNR ***
Istituto di Biochimica Delle Proteine, Via P. Castellino 111, 80131 Napoli, Italy
Istituto di Biostrutture e Bioimmagini, Consiglio Nazionale delle Ricerche, Via Mezzocannone 16, 80134 Napoli, Italy
References:
Rawlings, N.D., Tolle, D.P., Barrett, A.J., Evolutionary families of peptidase inhibitors (2004) Biochem. J, 378, pp. 705-71
Hengst, U., Albrecht, H., Hess, D., Monard, D., The phosphati- dyletanolamine-binding protein is the prototype of a novel family of serine protease inhibitors (2001) J. Biol. Chem, 276, pp. 535-540
Mima, J., Narita, Y., Chiba, H., Hayashi, R., The multiple site binding of carboxypeptidase Y inhibitor (IC) to the cognate proteinase. Implications for the biological roles of the phosphatidylethano-lamine-binding protein (2003) J. Biol. Chem, 278, pp. 29792-29800
Serre, L., Vallée, B., Bureaud, N., Schoentgen, F., Zelwer, C., Crystal structure of the phosphatidylethanolamine-binding protein from bovine brain: A novel structural class of phospholipid-binding proteins (1998) Structure, 6, pp. 1255-1265
Hall, L. A 23 kDa protein from rat sperm plasma membranes shows sequence similarity and phospholipid binding properties to a bovine brain cytosolic protein. Biochem. Biophys. Acta 1991, 1080, 78-82Vallee, B.S., Tauc, P., Brochon, J.C., Maget-Dana, R., Lelievre, D., Metz-Boutigue, M.-H., Bureaun, N., Schoentgen, F., Behaviour of bovine phosphatidylethanolamine-binding protein with model membranes (2001) Eur. J. Biochem, 268, pp. 5831-5841
Yeung, K., Seitz, T., Li, S., Janosch, P., McFerran, B., Kaiser, G., Fee, F., Koich, W., Suppression of Raf-1 kinase activity and MAP kinase signalling by RKIP (1999) Nature, 401, pp. 173-177
Bruun, A.W., Svendsen, I., Sorensen, S.0., Kielland-Brandt, M.C., Winther, J.R., A high-affinity inhibitor of yeast carboxypeptidase Y is encoded by TFS1 and shows homology to a family of lipid binding proteins (1998) Biochemistry, 37, pp. 3351-3357
Simister, P.C., Banfield, M.J., Brady, R.L., The crystal structure of PEBP-2, a homologue of the PEBP/RKIP family (2002) Acta Crystallogr., Sect. D, 58, pp. 1077-1080
Chen, Q., Wang, S., Thompson, S.N., Halland, E.D., Guttmann, R.P., Identification and characterization of PEBP as a calpain substrate (2006) J. Neurochem, 99, pp. 1133-1141
Chong, P.K., Wright, P.C., Identification and characterization of the Sulfolobus solfataricus P2 proteome (2005) J. Proteome Res, 4, pp. 1789-1798
Yoshida, K., Kobayashi, K., Miwa, Y., Rang, C., Matsunaga, M., Yamaguchi, H., Tojo, S., Fujita, Y., Protease removal by means of antipro-teases immobilized on supports as a potential tool for hemodialysis or extracorporeal blood circulation (2001) Nucleic Acids Res, 29, pp. 683-692
Le, Q.T., Katunuma, N., Detection of protease inhibitors by a reverse zymography method, performed in a tris(hydroxymethy-l)aminomethane-Tricine buffer system (2004) Anal. Biochem, 324, pp. 237-240
Altschul, S.F., Madden, T.L., Schaffer, A.A., Zhang, J., Zhang, Z., Miller, W., Lipman, D.J., Gapped BLAST and PSI-BLAST: A new generation of protein database search programs (1997) Nucleic Acids Res, 25, pp. 3389-3402
Serre, L., de Jesus, K.P., Zelwer, C., Bureaud, N., Schoentgen, F., Benedetti, H., Crystal structures of YBHB and YBCL from Escherichia coli, two bacterial homologues to a Raf kinase inhibitor protein (2001) J. Mol. Biol, 310, pp. 617-634
Banfield, M.J., Barker, J.J., Perryand, A.C.F., Brady, R.L., Function from structure? The crystal structure of human phosphatidyl-ethanolamine- binding protein suggests a role in membrane signal transduction (1998) J. Mol. Biol, 6, pp. 1245-1254
Khamrui, S., Dasgupta, J., Dattagupta, J.K., Sen, U., Single mutation at P1 of a chymotrypsin inhibitor changes it to a trypsin inhibitor: X-ray structural (2.15 A) and biochemical basis (2005) Biochim. Biophys. Acta, 1752, pp. 65-72
Bode, W., Huber, R., Natural protein proteinase inhibitors and their interaction with proteinases (1992) Eur. J. Biochem, 204, pp. 433-451
Mucsi, Z., Gaspari, Z., Orosz, G., Perczel, A., Structure-oriented rational design of chymotrypsin inhibitor models (2003) Protein Eng, 16, pp. 673-681
Huang, K., Strynadka, N., Bernard, V., Peanasky, R.J., Jamesl, M.N.G., The molecular structure of the complex of Ascaris chymotrypsin/elastase inhibitor with porcine elastase (1994) Structure, 2, pp. 679-689
Komiyama, T., Bigler, T.L., Yoshida, N., Noda, K., Laskowski Jr., M., Replacement of PI Leu" by Glu" in the reactive site of turkey ovomucoid third domain converts it into a strong inhibitor of Glu-specific Streptomyces griseus proteinase (GluSGP) (1991) J. Biol. Chem, 266, pp. 10727-10730
Greenblatt, H.M., Ryan, C.A., James, M.N.G., Structure of the complex of Streptomyces griseus proteinase B and polypeptide chymotrypsin inhibitor-1 from Russet Burbank potato tubers at 2.1k (1989) J. Mol. Biol, 205, pp. 201-228
Tshuogae, Y., Tanaka, I., Yamane, T., Kikkawa, J., Ashida, T., Ishikawa, C., Watanabe, K., Takahashi, K., Structure of the trypsin binding domain of Bowman-Birk type proteinase inhibitor and its interaction with trypsin (1986) J Biochem, 100, pp. 1637-1646
Apostoluk, W., Otlewski, J., Variability of the canonical loop conformations in serine proteinases inhibitors and other proteins (1998) Proteins: Struct., Fund., Genet, 32, pp. 459-474
Onesti, S., Brick, P., Blow, D.M., Crystal structure of a Kunitz-type trypsin inhibitor from Erythrina caffra seeds (1991) J. Mol. Biol, 217, pp. 153-176
Song, H.K., Suh, S.W., Kunitz-type soybean trypsin inhibitor revisited: Refined structure of its complex with porcine trypsin reveals an insight into the interaction between a homologous inhibitor from Erythrina caffra and tissue-type plasminogen activator (1998) J. Mol Biol, 275, pp. 347-363
De Meester, P., Brick, P., Lloyd, L.F., Blow, D.M., Onesti, S., Occurrence and physico-chemical properties of protease inhibitors (1998) Acta Crystallogr., Sect. D: Biol Crystallogr, 54, pp. 589-597
Dattagupta, J.K., Podder, A., Chakrabarti, C., Sen, U., Mukho-padhyay, D., Dutta, S.K., Singh, M., Refined crystal structure (2.3 A) of a double-headed winged bean-chymotrypsin inhibitor and location of its second reactive site (1999) Proteins: Struct. Funct. Genet, 54, pp. 321-331
Schechter, I., Berger, A., On the size of the active site in proteases (1967) I. Papain. Biochem. Biophys. Res. Communn, 27, pp. 157-162
Laskowski Jr., M., Kato, I., Protein inhibitors of proteases (1980) Annu. Rev. Biochem, 49, pp. 593-626
Mima, J., Hayashida, M., Fujii, T., Narita, Y., Hayashi, R., Ueda, M., Hata, Y., Structure of the carboxypeptidase Y inhibitor IC in complex with the cognate proteinase reveals a novel mode of the proteinase-protein inhibitor interaction (2005) J. Mol. Biol, 346, pp. 1323-1334
Grano, V., Diano, N., Portaccio, M., De Santo, N., Di Martino, S., Rossi, S., De Santo, L.S., Mita, D.G., Protease removal by means of antiproteases immobilized on supports as a potential tool for hemodialysis or extracorporeal blood circulation (2003) Int. J. Artif. Organs, 26, pp. 39-45
Rawlings, N. D., Tolle, D. P., Barrett, A. J., Evolutionary families of peptidase inhibitors (2004) Biochem. J, 378, pp. 705-71
Serre, L., Vall e, B., Bureaud, N., Schoentgen, F., Zelwer, C., Crystal structure of the phosphatidylethanolamine-binding protein from bovine brain: A novel structural class of phospholipid-binding proteins (1998) Structure, 6, pp. 1255-1265
Bruun, A. W., Svendsen, I., Sorensen, S. 0., Kielland-Brandt, M. C., Winther, J. R., A high-affinity inhibitor of yeast carboxypeptidase Y is encoded by TFS1 and shows homology to a family of lipid binding proteins (1998) Biochemistry, 37, pp. 3351-3357
Simister, P. C., Banfield, M. J., Brady, R. L., The crystal structure of PEBP-2, a homologue of the PEBP/RKIP family (2002) Acta Crystallogr., Sect. D, 58, pp. 1077-1080
Chong, P. K., Wright, P. C., Identification and characterization of the Sulfolobus solfataricus P2 proteome (2005) J. Proteome Res, 4, pp. 1789-1798
Le, Q. T., Katunuma, N., Detection of protease inhibitors by a reverse zymography method, performed in a tris (hydroxymethy-l) aminomethane-Tricine buffer system (2004) Anal. Biochem, 324, pp. 237-240
Altschul, S. F., Madden, T. L., Schaffer, A. A., Zhang, J., Zhang, Z., Miller, W., Lipman, D. J., Gapped BLAST and PSI-BLAST: A new generation of protein database search programs (1997) Nucleic Acids Res, 25, pp. 3389-3402
Banfield, M. J., Barker, J. J., Perryand, A. C. F., Brady, R. L., Function from structure? The crystal structure of human phosphatidyl-ethanolamine- binding protein suggests a role in membrane signal transduction (1998) J. Mol. Biol, 6, pp. 1245-1254
Greenblatt, H. M., Ryan, C. A., James, M. N. G., Structure of the complex of Streptomyces griseus proteinase B and polypeptide chymotrypsin inhibitor-1 from Russet Burbank potato tubers at 2. 1k (1989) J. Mol. Biol, 205, pp. 201-228
Song, H. K., Suh, S. W., Kunitz-type soybean trypsin inhibitor revisited: Refined structure of its complex with porcine trypsin reveals an insight into the interaction between a homologous inhibitor from Erythrina caffra and tissue-type plasminogen activator (1998) J. Mol Biol, 275, pp. 347-363
Dattagupta, J. K., Podder, A., Chakrabarti, C., Sen, U., Mukho-padhyay, D., Dutta, S. K., Singh, M., Refined crystal structure (2. 3 A) of a double-headed winged bean-chymotrypsin inhibitor and location of its second reactive site (1999) Proteins: Struct. Funct. Genet, 54, pp. 321-331
J Proteome Res (ISSN: 1535-3893), 2009 Jan; 8(1): 327-334.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 5.132, 5-year impact factor: 5.359
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-60849083258&partnerID=40&md5=ad3f5a0a11742f59cc991e34f30a01c7
Keywords: Homology Modeling, Pebp, Protease Binding Site, Protease Inhibitor Family, Serine Protease Inhibitor, Sulfolobus Solfataricus, Anion, Bacterial Protein, Chymotrypsin A, Elastase, Gene Product, Monomer, Phosphatidylethanolamine Binding Protein, Protein Sscei, Protein Sso0767, Serine Proteinase Inhibitor, Unclassified Drug, Alpha-Chymotrypsin, Amino Acid Sequence, Article, Carboxy Terminal Sequence, Drug Isolation, Drug Structure, Enzyme Active Site, Gene Inactivation, Inhibition Kinetics, Molecular Cloning, Molecular Weight, Nonhuman, Point Mutation, Prediction, Priority Journal, Protein Degradation, Protein Family, Protein Folding, Protein Motif, Protein Structure, Sequence Homology, Surface Property, Archaebacterium, Chemistry, Conformation, Escherichia Coli, Mass Spectrometry, Metabolism, Methodology, Molecular Genetics, Proteomics, Murinae, Catalytic Domain, Molecular Conformation, Molecular Sequence Data, Serine Endopeptidases,
Affiliations:
*** IBB - CNR ***
Istituto di Biochimica Delle Proteine, Via P. Castellino 111, 80131 Napoli, Italy
Istituto di Biostrutture e Bioimmagini, Consiglio Nazionale delle Ricerche, Via Mezzocannone 16, 80134 Napoli, Italy
References:
Rawlings, N.D., Tolle, D.P., Barrett, A.J., Evolutionary families of peptidase inhibitors (2004) Biochem. J, 378, pp. 705-71
Hengst, U., Albrecht, H., Hess, D., Monard, D., The phosphati- dyletanolamine-binding protein is the prototype of a novel family of serine protease inhibitors (2001) J. Biol. Chem, 276, pp. 535-540
Mima, J., Narita, Y., Chiba, H., Hayashi, R., The multiple site binding of carboxypeptidase Y inhibitor (IC) to the cognate proteinase. Implications for the biological roles of the phosphatidylethano-lamine-binding protein (2003) J. Biol. Chem, 278, pp. 29792-29800
Serre, L., Vallée, B., Bureaud, N., Schoentgen, F., Zelwer, C., Crystal structure of the phosphatidylethanolamine-binding protein from bovine brain: A novel structural class of phospholipid-binding proteins (1998) Structure, 6, pp. 1255-1265
Hall, L. A 23 kDa protein from rat sperm plasma membranes shows sequence similarity and phospholipid binding properties to a bovine brain cytosolic protein. Biochem. Biophys. Acta 1991, 1080, 78-82Vallee, B.S., Tauc, P., Brochon, J.C., Maget-Dana, R., Lelievre, D., Metz-Boutigue, M.-H., Bureaun, N., Schoentgen, F., Behaviour of bovine phosphatidylethanolamine-binding protein with model membranes (2001) Eur. J. Biochem, 268, pp. 5831-5841
Yeung, K., Seitz, T., Li, S., Janosch, P., McFerran, B., Kaiser, G., Fee, F., Koich, W., Suppression of Raf-1 kinase activity and MAP kinase signalling by RKIP (1999) Nature, 401, pp. 173-177
Bruun, A.W., Svendsen, I., Sorensen, S.0., Kielland-Brandt, M.C., Winther, J.R., A high-affinity inhibitor of yeast carboxypeptidase Y is encoded by TFS1 and shows homology to a family of lipid binding proteins (1998) Biochemistry, 37, pp. 3351-3357
Simister, P.C., Banfield, M.J., Brady, R.L., The crystal structure of PEBP-2, a homologue of the PEBP/RKIP family (2002) Acta Crystallogr., Sect. D, 58, pp. 1077-1080
Chen, Q., Wang, S., Thompson, S.N., Halland, E.D., Guttmann, R.P., Identification and characterization of PEBP as a calpain substrate (2006) J. Neurochem, 99, pp. 1133-1141
Chong, P.K., Wright, P.C., Identification and characterization of the Sulfolobus solfataricus P2 proteome (2005) J. Proteome Res, 4, pp. 1789-1798
Yoshida, K., Kobayashi, K., Miwa, Y., Rang, C., Matsunaga, M., Yamaguchi, H., Tojo, S., Fujita, Y., Protease removal by means of antipro-teases immobilized on supports as a potential tool for hemodialysis or extracorporeal blood circulation (2001) Nucleic Acids Res, 29, pp. 683-692
Le, Q.T., Katunuma, N., Detection of protease inhibitors by a reverse zymography method, performed in a tris(hydroxymethy-l)aminomethane-Tricine buffer system (2004) Anal. Biochem, 324, pp. 237-240
Altschul, S.F., Madden, T.L., Schaffer, A.A., Zhang, J., Zhang, Z., Miller, W., Lipman, D.J., Gapped BLAST and PSI-BLAST: A new generation of protein database search programs (1997) Nucleic Acids Res, 25, pp. 3389-3402
Serre, L., de Jesus, K.P., Zelwer, C., Bureaud, N., Schoentgen, F., Benedetti, H., Crystal structures of YBHB and YBCL from Escherichia coli, two bacterial homologues to a Raf kinase inhibitor protein (2001) J. Mol. Biol, 310, pp. 617-634
Banfield, M.J., Barker, J.J., Perryand, A.C.F., Brady, R.L., Function from structure? The crystal structure of human phosphatidyl-ethanolamine- binding protein suggests a role in membrane signal transduction (1998) J. Mol. Biol, 6, pp. 1245-1254
Khamrui, S., Dasgupta, J., Dattagupta, J.K., Sen, U., Single mutation at P1 of a chymotrypsin inhibitor changes it to a trypsin inhibitor: X-ray structural (2.15 A) and biochemical basis (2005) Biochim. Biophys. Acta, 1752, pp. 65-72
Bode, W., Huber, R., Natural protein proteinase inhibitors and their interaction with proteinases (1992) Eur. J. Biochem, 204, pp. 433-451
Mucsi, Z., Gaspari, Z., Orosz, G., Perczel, A., Structure-oriented rational design of chymotrypsin inhibitor models (2003) Protein Eng, 16, pp. 673-681
Huang, K., Strynadka, N., Bernard, V., Peanasky, R.J., Jamesl, M.N.G., The molecular structure of the complex of Ascaris chymotrypsin/elastase inhibitor with porcine elastase (1994) Structure, 2, pp. 679-689
Komiyama, T., Bigler, T.L., Yoshida, N., Noda, K., Laskowski Jr., M., Replacement of PI Leu" by Glu" in the reactive site of turkey ovomucoid third domain converts it into a strong inhibitor of Glu-specific Streptomyces griseus proteinase (GluSGP) (1991) J. Biol. Chem, 266, pp. 10727-10730
Greenblatt, H.M., Ryan, C.A., James, M.N.G., Structure of the complex of Streptomyces griseus proteinase B and polypeptide chymotrypsin inhibitor-1 from Russet Burbank potato tubers at 2.1k (1989) J. Mol. Biol, 205, pp. 201-228
Tshuogae, Y., Tanaka, I., Yamane, T., Kikkawa, J., Ashida, T., Ishikawa, C., Watanabe, K., Takahashi, K., Structure of the trypsin binding domain of Bowman-Birk type proteinase inhibitor and its interaction with trypsin (1986) J Biochem, 100, pp. 1637-1646
Apostoluk, W., Otlewski, J., Variability of the canonical loop conformations in serine proteinases inhibitors and other proteins (1998) Proteins: Struct., Fund., Genet, 32, pp. 459-474
Onesti, S., Brick, P., Blow, D.M., Crystal structure of a Kunitz-type trypsin inhibitor from Erythrina caffra seeds (1991) J. Mol. Biol, 217, pp. 153-176
Song, H.K., Suh, S.W., Kunitz-type soybean trypsin inhibitor revisited: Refined structure of its complex with porcine trypsin reveals an insight into the interaction between a homologous inhibitor from Erythrina caffra and tissue-type plasminogen activator (1998) J. Mol Biol, 275, pp. 347-363
De Meester, P., Brick, P., Lloyd, L.F., Blow, D.M., Onesti, S., Occurrence and physico-chemical properties of protease inhibitors (1998) Acta Crystallogr., Sect. D: Biol Crystallogr, 54, pp. 589-597
Dattagupta, J.K., Podder, A., Chakrabarti, C., Sen, U., Mukho-padhyay, D., Dutta, S.K., Singh, M., Refined crystal structure (2.3 A) of a double-headed winged bean-chymotrypsin inhibitor and location of its second reactive site (1999) Proteins: Struct. Funct. Genet, 54, pp. 321-331
Schechter, I., Berger, A., On the size of the active site in proteases (1967) I. Papain. Biochem. Biophys. Res. Communn, 27, pp. 157-162
Laskowski Jr., M., Kato, I., Protein inhibitors of proteases (1980) Annu. Rev. Biochem, 49, pp. 593-626
Mima, J., Hayashida, M., Fujii, T., Narita, Y., Hayashi, R., Ueda, M., Hata, Y., Structure of the carboxypeptidase Y inhibitor IC in complex with the cognate proteinase reveals a novel mode of the proteinase-protein inhibitor interaction (2005) J. Mol. Biol, 346, pp. 1323-1334
Grano, V., Diano, N., Portaccio, M., De Santo, N., Di Martino, S., Rossi, S., De Santo, L.S., Mita, D.G., Protease removal by means of antiproteases immobilized on supports as a potential tool for hemodialysis or extracorporeal blood circulation (2003) Int. J. Artif. Organs, 26, pp. 39-45
Rawlings, N. D., Tolle, D. P., Barrett, A. J., Evolutionary families of peptidase inhibitors (2004) Biochem. J, 378, pp. 705-71
Serre, L., Vall e, B., Bureaud, N., Schoentgen, F., Zelwer, C., Crystal structure of the phosphatidylethanolamine-binding protein from bovine brain: A novel structural class of phospholipid-binding proteins (1998) Structure, 6, pp. 1255-1265
Bruun, A. W., Svendsen, I., Sorensen, S. 0., Kielland-Brandt, M. C., Winther, J. R., A high-affinity inhibitor of yeast carboxypeptidase Y is encoded by TFS1 and shows homology to a family of lipid binding proteins (1998) Biochemistry, 37, pp. 3351-3357
Simister, P. C., Banfield, M. J., Brady, R. L., The crystal structure of PEBP-2, a homologue of the PEBP/RKIP family (2002) Acta Crystallogr., Sect. D, 58, pp. 1077-1080
Chong, P. K., Wright, P. C., Identification and characterization of the Sulfolobus solfataricus P2 proteome (2005) J. Proteome Res, 4, pp. 1789-1798
Le, Q. T., Katunuma, N., Detection of protease inhibitors by a reverse zymography method, performed in a tris (hydroxymethy-l) aminomethane-Tricine buffer system (2004) Anal. Biochem, 324, pp. 237-240
Altschul, S. F., Madden, T. L., Schaffer, A. A., Zhang, J., Zhang, Z., Miller, W., Lipman, D. J., Gapped BLAST and PSI-BLAST: A new generation of protein database search programs (1997) Nucleic Acids Res, 25, pp. 3389-3402
Banfield, M. J., Barker, J. J., Perryand, A. C. F., Brady, R. L., Function from structure? The crystal structure of human phosphatidyl-ethanolamine- binding protein suggests a role in membrane signal transduction (1998) J. Mol. Biol, 6, pp. 1245-1254
Greenblatt, H. M., Ryan, C. A., James, M. N. G., Structure of the complex of Streptomyces griseus proteinase B and polypeptide chymotrypsin inhibitor-1 from Russet Burbank potato tubers at 2. 1k (1989) J. Mol. Biol, 205, pp. 201-228
Song, H. K., Suh, S. W., Kunitz-type soybean trypsin inhibitor revisited: Refined structure of its complex with porcine trypsin reveals an insight into the interaction between a homologous inhibitor from Erythrina caffra and tissue-type plasminogen activator (1998) J. Mol Biol, 275, pp. 347-363
Dattagupta, J. K., Podder, A., Chakrabarti, C., Sen, U., Mukho-padhyay, D., Dutta, S. K., Singh, M., Refined crystal structure (2. 3 A) of a double-headed winged bean-chymotrypsin inhibitor and location of its second reactive site (1999) Proteins: Struct. Funct. Genet, 54, pp. 321-331
First archaeal PEPB-serine protease inhibitor from sulfolobus solfataricus with noncanonical amino acid sequence in the reactive-site loop
The specific inhibition of serine proteinases, which are crucial switches in many important physiological processes, is of great value both for basic research and for therapeutic applications. In this study, we report the molecular cloning of the sso0767 gene from Sulfolobus solfataricus, and the functional characterization of its product, SsCEl, which represents the first archaeal phosphatidylethanolamine-binding protein (PEBP)-serine proteinase inhibitor, reported to date. SsCEl is a monomer protein with a molecular mass of 19.0 kDa and a p/ of 6.7, which is able to inhibit the serine proteases a-chymotrypsin and elastase with Ki values of 0.08 and 0.1 μM, respectively. Moreover SsCEl is extremely resistant to both thermal inactivation and proteolytic attack suggesting compact folding of the protein. Within the 151 family, the archaeal inhibitor shows strong similarity to the human and murine members. The three-dimensional model of SsCEl revealed a general 7beta;-fold and the presence of an anion-binding pocket, the hallmark of the PEBP family. Moreover SsCEl binds the cognate proteases according to a common, substrate-like standard mechanism. Point mutation experiments supported the prediction of the protease-binding site located on the surface at the C-terminal region of the protein. Interestingly, searches based on preidentified structural reactive loop motifs revealed the occurrence of a sequence (T123-N130) that is not represented in all serine-protease inhibitor families. This unique motif may provide new insights into both the inhibitor/protease binding mode and the specific biological functions of SsCEl within the PEBP family. © 2009 American Chemical Society.
The specific inhibition of serine proteinases, which are crucial switches in many important physiological processes, is of great value both for basic research and for therapeutic applications. In this study, we report the molecular cloning of the sso0767 gene from Sulfolobus solfataricus, and the functional characterization of its product, SsCEl, which represents the first archaeal phosphatidylethanolamine-binding protein (PEBP)-serine proteinase inhibitor, reported to date. SsCEl is a monomer protein with a molecular mass of 19.0 kDa and a p/ of 6.7, which is able to inhibit the serine proteases a-chymotrypsin and elastase with Ki values of 0.08 and 0.1 μM, respectively. Moreover SsCEl is extremely resistant to both thermal inactivation and proteolytic attack suggesting compact folding of the protein. Within the 151 family, the archaeal inhibitor shows strong similarity to the human and murine members. The three-dimensional model of SsCEl revealed a general 7beta;-fold and the presence of an anion-binding pocket, the hallmark of the PEBP family. Moreover SsCEl binds the cognate proteases according to a common, substrate-like standard mechanism. Point mutation experiments supported the prediction of the protease-binding site located on the surface at the C-terminal region of the protein. Interestingly, searches based on preidentified structural reactive loop motifs revealed the occurrence of a sequence (T123-N130) that is not represented in all serine-protease inhibitor families. This unique motif may provide new insights into both the inhibitor/protease binding mode and the specific biological functions of SsCEl within the PEBP family. © 2009 American Chemical Society.
First archaeal PEPB-serine protease inhibitor from sulfolobus solfataricus with noncanonical amino acid sequence in the reactive-site loop
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First archaeal PEPB-serine protease inhibitor from sulfolobus solfataricus with noncanonical amino acid sequence in the reactive-site loop
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* Screening of beta-hairpin peptide-engrafted 1, 2, 3-triazoles to identify APEH enzyme inhibitors (412 views)
Rsc Adv (ISSN: 2046-2069), 2015; 5(13): 9965-9972.
Impact Factor: 3.289
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Pedone E, Fiorentino G, Pirone L, Contursi P, Bartolucci S, Limauro D
* Functional and structural characterization of protein disulfide oxidoreductase from Thermus thermophilus HB27 (343 views)
Extremophiles (ISSN: 1431-0651, 1433-4909, 1433-4909electronic), 2014 Jul; 18(4): 723-731.
Impact Factor: 2.306
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Limauro D, De Simone G, Pirone L, Bartolucci S, D'Ambrosio K, Pedone E
* Sulfolobus solfataricus thiol redox puzzle: characterization of an atypical protein disulfide oxidoreductase (430 views)
Extremophiles (ISSN: 1431-0651, 1433-4909, 1433-4909electronic), 2014 Mar; 18(2): 219-228.
Impact Factor: 2.306
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Martucci NM, Lamberti A, Vitagliano L, Cantiello P, Ruggiero I, Arcari P, Masullo M
* The magic spot ppGpp influences in vitro the molecular and functional properties of the elongation factor 1α from the archaeon Sulfolobus solfataricus (350 views)
Extremophiles (ISSN: 1431-0651, 1433-4909, 1433-4909electronic), 2012 Sep; 16(5): 743-749.
Impact Factor: 2.203
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Esposito L, Ruggiero A, Masullo M, Ruocco MR, Lamberti A, Arcari P, Zagari A, Vitagliano L
* Crystallographic and spectroscopic characterizations of Sulfolobus solfataricus TrxA1 provide insights into the determinants of thioredoxin fold stability (301 views)
J Struct Biol (ISSN: 1047-8477, 1047-8477linking), 2012 Feb; 177(2): 506-512.
Impact Factor: 3.361
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Palmieri G, Bergamo P, Luini A, Ruvo M, Gogliettino M, Langella E, Saviano M, Hegde RN, Sandomenico A, Rossi M
* Acylpeptide hydrolase inhibition as targeted strategy to induce proteasomal down-regulation (508 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2011 Oct 10; 6(10): e25888-e25888.
Impact Factor: 4.092
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Calvanese L, Marasco D, Doti N, Saporito A, D'Auria G, Paolillo L, Ruvo M, Falcigno L
* Structural Investigations on the Nodal-Cripto Binding: A Theoretical and Experimental Approach (596 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2010 Nov; 93(11): 1011-1021.
Impact Factor: 2.572
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Limauro D, D'Ambrosio K, Langella E, De Simone G, Galdi I, Pedone C, Pedone E, Bartolucci S
* Exploring the catalytic mechanism of the first dimeric Bcp: Functional, structural and docking analyses of Bcp4 from Sulfolobus solfataricus (375 views)
Biochimie (ISSN: 1638-6183, 0300-9084, 1638-6183electronic), 2010 Oct; 92(10): 1435-1444.
Impact Factor: 3.787
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Alfieri A, Pasanisi F, Salzano S, Esposito L, Martone D, Tafuri D, Daniele A, Contaldo F, Sacchetti L, Zagari A, Buono P
* Functional analysis of melanocortin-4-receptor mutants identified in severely obese subjects living in Southern Italy (397 views)
Gene (ISSN: 0378-1119), 2010 Jun 1; 457(1-2): 35-41.
Impact Factor: 2.266
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Palmieri G, Langella E, Gogliettino M, Saviano M, Pocsfalvi G, Rossi M
* A novel class of protease targets of phosphatidylethanolamine-binding proteins (PEBP): A study of the acylpeptide hydrolase and the PEBP inhibitor from the archaeon Sulfolobus solfataricus (378 views)
Mol Biosyst (ISSN: 1742-206x), 2010; 6(12): 2498-2507.
Impact Factor: 3.825
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Ruggiero A, Masullo M, Marasco D, Ruocco MR, Grimaldi P, Arcari P, Zagari A, Vitagliano L
* The dimeric structure of Sulfolobus solfataricus thioredoxin A2 and the basis of its thermostability (436 views)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2009 Dec; 77(4): 1004-1008.
Impact Factor: 3.085
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D'Ambrosio K, Limauro D, Pedone E, Galdi I, Pedone C, Bartolucci S, De Simone G
* Insights into the catalytic mechanism of the Bcp family: functional and structural analysis of Bcp1 from Sulfolobus solfataricus (539 views)
Proteins (ISSN: 1097-0134, 0887-3585, 1097-0134electronic), 2009 Sep; 76(4): 995-1006.
Impact Factor: 3.085
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Pennacchio A, Esposito L, Zagari A, Rossi M, Raia CA
* Role of Tryptophan 95 in substrate specificity and structural stability of Sulfolobus solfataricus alcohol dehydrogenase (298 views)
Extremophiles (ISSN: 1431-0651, 1433-4909, 1433-4909electronic), 2009 Sep; 13(5): 751-761.
Impact Factor: 2
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Ruggiero I, Cantiello P, Lamberti A, Sorrentino A, Martucci NM, Ruggiero A, Arcone R, Vitagliano L, Arcari P, Masullo M
* Biochemical Characterisation Of The D60a Mutant Of The Elongation Factor 1 Alpha From The Archaeon Sulfolobus Solfataricus (324 views)
Biochimie (ISSN: 0300-9084, 1638-6183, 1638-6183electronic), 2009 Jul; 91(7): 835-842.
Impact Factor: 3.897
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Ruggiero A, Lanzotti MA, Ruocco MR, Grimaldi P, Marasco D, Arcari P, Masullo M, Zagari A, Vitagliano L
* Crystallization and preliminary X-ray crystallographic analysis of two dimeric hyperthermostable thioredoxins isolated from Sulfolobus solfataricus (337 views)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1744-3091, 1744-4309), 2009 Jun; 65: 604-607.
Impact Factor: 0.551
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Di Fiore A, Fiorentino G, Vitale RM, Ronca R, Amodeo P, Pedone C, Bartolucci S, De Simone G
* Structural analysis of BldR from Sulfolobus solfataricus provides insights into the molecular basis of transcriptional activation in Archaea by MarR family proteins (470 views)
J Mol Biol (ISSN: 1089-8638, 0022-2836, 1089-8638electronic), 2009 May 8; 388(3): 559-569.
Impact Factor: 3.871
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Ruggiero A, Masullo M, Ruocco MR, Grimaldi P, Lanzotti MA, Arcari P, Zagari A, Vitagliano L
* Structure and stability of a thioredoxin reductase from Sulfolobus solfataricus: A thermostable protein with two functions (347 views)
Bba-Gen Subjects (ISSN: 1570-9639, 0006-3002, 0925-4439), 2009 Mar; 1794(3): 554-562.
Impact Factor: 2.48
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Francalanci F, Avolio M, De Luca E, Longo DL, Menchise V, Guazzi P, Sgro F, Marino M, Goitre L, Balzac F, Trabalzini L, Retta SF
* Structural and functional differences between KRIT1A and KRIT1B isoforms: A framework for understanding CCM pathogenesis (525 views)
Exp Cell Res (ISSN: 0014-4827), 2009 Jan 15; 315(2): 285-303.
Impact Factor: 3.589
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Limauro D, Saviano M, Galdi I, Rossi M, Bartolucci S, Pedone E
* Sulfolobus solfataricus protein disulphide oxidoreductase: insight into the roles of its redox sites (236 views)
Protein Engineering Design & Selection (ISSN: 1741-0126), 2009 Jan; 22(1): 19-26.
Impact Factor: 2.596
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Grimaldi P, Ruocco MR, Lanzotti MA, Ruggiero A, Ruggiero I, Arcari P, Vitagliano L, Masullo M
* Characterisation of the components of the thioredoxin system in the archaeon Sulfolobus solfataricus (370 views)
Extremophiles (ISSN: 1431-0651, 1433-4909, 1433-4909electronic), 2008 Jul; 12(4): 553-562.
Impact Factor: 1.782
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Limauro D, Pedone E, Galdi I, Bartolucci S
* Peroxiredoxins as cellular guardians in Sulfolobus solfataricus - characterization of Bcp1, Bcp3 and Bcp4 (385 views)
Febs Journal (ISSN: 1742-464x), 2008 May; 275(9): 2067-2077.
Impact Factor: 3.139
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Granata V, Graziano G, Ruggiero A, Raimo G, Masullo M, Arcari P, Vitagliano L, Zagari A
* Stability Against Temperature Of Sulfolobus Solfataricus Elongation Factor 1 Alpha, A Multi-Domain Protein (380 views)
Bba-Gen Subjects (ISSN: 1570-9639, 0006-3002, 0925-4439), 2008 Apr; 1784(4): 573-581.
Impact Factor: 2.233
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Prato S, Vitale RM, Contursi P, Lipps G, Saviano M, Rossi M, Bartolucci S
* Molecular modeling and functional characterization of the monomeric primase-polymerase domain from the Sulfolobus solfataricus plasmid pIT3 (402 views)
Febs J (ISSN: 1742-464x), 2008; 275(17): 4389-4402.
Impact Factor: 3.139
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Ragno R, Simeoni S, Castellano S, Vicidomini C, Mai A, Caroli A, Tramontano A, Bonaccini C, Trojer P, Bauer I, Brosch G, Sbardella G
* Small molecule inhibitors of histone arginine methyltransferases: Homology modeling, molecular docking, binding mode analysis, and biological evaluations (965 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2007 Mar 22; 50(6): 1241-1253.
Impact Factor: 4.895
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Pedone E, Limauro D, D'Alterio R, Rossi M, Bartolucci S
* Characterization of a multifunctional protein disulfide oxidoreductase from Sulfolobus solfataricus (330 views)
Febs Journal (ISSN: 1742-464x), 2006 Dec; 273(23): 5407-5420.
Impact Factor: 3.033
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Limauro D, Pedone E, Pirone L, Bartolucci S
* Identification and characterization of 1-Cys peroxiredoxin from Sulfolobus solfataricus and its involvement in the response to oxidative stress (378 views)
Febs Journal (ISSN: 1742-464x), 2006 Feb; 273(4): 721-731.
Impact Factor: 3.033
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Granata V, Graziano G, Ruggiero A, Raimo G, Masullo M, Arcari P, Vitagliano L, Zagari A
* Chemical Denaturation Of The Elongation Factor 1 Alpha Isolated From The Hyperthermophilic Archaeon Sulfolobus Solfataricus (358 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2006 Jan 24; 45(3): 719-726.
Impact Factor: 3.633
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Ruggiero A, Masullo M, Arcari P, Raimo G, Vitagliano L, Zagari A
* Crystallization And Preliminary X-Ray Crystallographic Analysis Of The Sulfolobus Solfataricus Nucleotide-Exchange Factor 1 Beta (340 views)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1744-3091, 1744-4309), 2005 Nov; 61(11): 1000-1002.
Impact Factor: 0.568
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Ruggiero A, Ruocco MR, Grimaldi P, Arcari P, Masullo M, Zagari A, Vitagliano L
* Crystallization and preliminary X-ray crystallographic analysis of Sulfolobus solfataricus thioredoxin reductase (319 views)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1744-3091, 1744-4309), 2005 Oct; 61: 906-909.
Impact Factor: 0.568
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Merlino A, Graziano G, Mazzarella L
* Structural And Dynamic Effects Of Alpha-Helix Deletion In Sso7d: Implications For Protein Thermal Stability (423 views)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2004 Dec 1; 57(4): 692-701.
Impact Factor: 4.429
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Vitagliano L, Ruggiero A, Masullo M, Cantiello P, Arcari P, Zagari A
* The Crystal Structure Of Sulfolobus Solfataricus Elongation Factor 1 Alpha In Complex With Magnesium And Gdp (483 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2004; 43(21): 6630-6636.
Impact Factor: 4.008
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Esposito L, Bruno I, Sica F, Raia CA, Giordano A, Rossi M, Mazzarella L, Zagari A
* Crystal structure of a ternary complex of the alcohol dehydrogenase from Sulfolobus solfataricus (545 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2003 Dec 16; 42(49): 14397-14407.
Impact Factor: 3.922
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Esposito L, Bruno I, Sica F, Raia CA, Giordano A, Rossi M, Mazzarella L, Zagari A
* Structural study of a single-point mutant of Sulfolobus solfataricus alcohol dehydrogenase with enhanced activity (313 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 2003 Mar 27; 539(1-3): 14-18.
Impact Factor: 3.609
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Esposito L, Sica F, Raia CA, Giordano A, Rossi M, Mazzarella L, Zagari A
* Crystal Structure Of The Alcohol Dehydrogenase From The Hyperthermophilic Archaeon Sulfolobus Solfataricus At 1. 85 Angstrom Resolution (476 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2002 Apr 26; 318(2): 463-477.
Impact Factor: 5.359
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Masullo M, Cantiello P, Paola B, Fiengo A, Vitagliano L, Zagari A, Arcari P
* Valine114 Replacements In The Archaeal Elongation Factor 1a Enhanced Its Ability To Interact With Aminoacyl-Trna And Kirromycin (353 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2002; 41(49): 14482-14488.
Impact Factor: 4.064
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Vitagliano L, Masullo M, Sica F, Zagari A, Bocchini V
* The crystal structure of Sulfolobus solfataricus elongation factor 1α in complex with GDP reveals novel features in nucleotide binding and exchange (457 views)
Embo J (ISSN: 0261-4189, 0261-4189linking), 2001 Oct 1; 20(19): 5305-5311.
Impact Factor: 12.459
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Esposito L, Sica F, Sorrentino G, Berisio R, Carotenuto L, Giordano A, Raia C, Rossi M, Lamzin VS, Willson KS, Zagari A
Protein Crystal Growth In The Advance Protein Crystallisation Facility On The Lms Mission: A Comparison Of Sulfolobus Solfataricus Alchool Dehydrogenase Crystals Grown On The Ground And In Microgravity (253 views)
Acta Crystallogr D Biol Crystallogr, 1998; 54: 386-390.
Impact Factor: 0
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Esposito L, Sica F, Sorrentino G, Berisio R, Carotenuto L, Giordano A, Raia CA, Rossi M, Lamzin VS, Wilson KS, Zagari A
Protein crystal growth in the advanced protein crystallization facility on the LMS mission: A comparison of Sulfolobus solfataricus alcohol dehydrogenase crystals grown on the ground and in microgravity (433 views)
Acta Crystallogr D Biol Crystallogr (ISSN: 0907-4449, 0907-4449linking), 1998; 54(3): 386-390.
Impact Factor: 2.244
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PEARL L, DEMASI D, HEMMINGS A, SICA F, MAZZARELLA L, RAIA C, DAURIA S, ROSSI M
CRYSTALLIZATION AND PRELIMINARY-X-RAY ANALYSIS OF AN NAD+-DEPENDENT ALCOHOL-DEHYDROGENASE FROM THE EXTREME THERMOPHILIC ARCHAEBACTERIUM SULFOLOBUS-SOLFATARICUS (445 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 1993 Feb 5; 229(3): 782-784.
Impact Factor: 5.673
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* Ultra-rapid glutathionylation of chymotrypsinogen in its molten globule-like conformation: A comparison to archaeal proteins (62 views)
Sci Rep (ISSN: 2045-2322linking, 2045-2322electronic), 2020 Jun 2; 10(1): 8943-8943.
Impact Factor: 3.998
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Ruggiero A, Smaldone G, Esposito L, Balasco N, Vitagliano L
* Loop size optimization induces a strong thermal stabilization of the thioredoxin fold (193 views)
Febs J (ISSN: 1742-464xlinking), 2019 May; 286(9): 1752-1764.
Impact Factor: 3.129
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De Simone G, Di Fiore A, Capasso C, Supuran CT
* The zinc coordination pattern in the eta-carbonic anhydrase from Plasmodium falciparum is different from all other carbonic anhydrase genetic families (472 views)
Bioorg Med Chem Lett (ISSN: 0960-894x), 2015 Apr 1; 25(7): 1385-1389.
Impact Factor: 2.486
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Sandomenico A, Celentano V, D'Andrea LD, Palmieri G, Ruvo M
* Screening of beta-hairpin peptide-engrafted 1, 2, 3-triazoles to identify APEH enzyme inhibitors (412 views)
Rsc Adv (ISSN: 2046-2069), 2015; 5(13): 9965-9972.
Impact Factor: 3.289
View Export to BibTeX Export to EndNote
Pedone E, Fiorentino G, Pirone L, Contursi P, Bartolucci S, Limauro D
* Functional and structural characterization of protein disulfide oxidoreductase from Thermus thermophilus HB27 (343 views)
Extremophiles (ISSN: 1431-0651, 1433-4909, 1433-4909electronic), 2014 Jul; 18(4): 723-731.
Impact Factor: 2.306
View Export to BibTeX Export to EndNote
Limauro D, De Simone G, Pirone L, Bartolucci S, D'Ambrosio K, Pedone E
* Sulfolobus solfataricus thiol redox puzzle: characterization of an atypical protein disulfide oxidoreductase (430 views)
Extremophiles (ISSN: 1431-0651, 1433-4909, 1433-4909electronic), 2014 Mar; 18(2): 219-228.
Impact Factor: 2.306
View Export to BibTeX Export to EndNote
Martucci NM, Lamberti A, Vitagliano L, Cantiello P, Ruggiero I, Arcari P, Masullo M
* The magic spot ppGpp influences in vitro the molecular and functional properties of the elongation factor 1α from the archaeon Sulfolobus solfataricus (350 views)
Extremophiles (ISSN: 1431-0651, 1433-4909, 1433-4909electronic), 2012 Sep; 16(5): 743-749.
Impact Factor: 2.203
View Export to BibTeX Export to EndNote
Esposito L, Ruggiero A, Masullo M, Ruocco MR, Lamberti A, Arcari P, Zagari A, Vitagliano L
* Crystallographic and spectroscopic characterizations of Sulfolobus solfataricus TrxA1 provide insights into the determinants of thioredoxin fold stability (301 views)
J Struct Biol (ISSN: 1047-8477, 1047-8477linking), 2012 Feb; 177(2): 506-512.
Impact Factor: 3.361
View Export to BibTeX Export to EndNote
Palmieri G, Bergamo P, Luini A, Ruvo M, Gogliettino M, Langella E, Saviano M, Hegde RN, Sandomenico A, Rossi M
* Acylpeptide hydrolase inhibition as targeted strategy to induce proteasomal down-regulation (508 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2011 Oct 10; 6(10): e25888-e25888.
Impact Factor: 4.092
View Export to BibTeX Export to EndNote
Calvanese L, Marasco D, Doti N, Saporito A, D'Auria G, Paolillo L, Ruvo M, Falcigno L
* Structural Investigations on the Nodal-Cripto Binding: A Theoretical and Experimental Approach (596 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2010 Nov; 93(11): 1011-1021.
Impact Factor: 2.572
View Export to BibTeX Export to EndNote
Limauro D, D'Ambrosio K, Langella E, De Simone G, Galdi I, Pedone C, Pedone E, Bartolucci S
* Exploring the catalytic mechanism of the first dimeric Bcp: Functional, structural and docking analyses of Bcp4 from Sulfolobus solfataricus (375 views)
Biochimie (ISSN: 1638-6183, 0300-9084, 1638-6183electronic), 2010 Oct; 92(10): 1435-1444.
Impact Factor: 3.787
View Export to BibTeX Export to EndNote
Alfieri A, Pasanisi F, Salzano S, Esposito L, Martone D, Tafuri D, Daniele A, Contaldo F, Sacchetti L, Zagari A, Buono P
* Functional analysis of melanocortin-4-receptor mutants identified in severely obese subjects living in Southern Italy (397 views)
Gene (ISSN: 0378-1119), 2010 Jun 1; 457(1-2): 35-41.
Impact Factor: 2.266
View Export to BibTeX Export to EndNote
Palmieri G, Langella E, Gogliettino M, Saviano M, Pocsfalvi G, Rossi M
* A novel class of protease targets of phosphatidylethanolamine-binding proteins (PEBP): A study of the acylpeptide hydrolase and the PEBP inhibitor from the archaeon Sulfolobus solfataricus (378 views)
Mol Biosyst (ISSN: 1742-206x), 2010; 6(12): 2498-2507.
Impact Factor: 3.825
View Export to BibTeX Export to EndNote
Ruggiero A, Masullo M, Marasco D, Ruocco MR, Grimaldi P, Arcari P, Zagari A, Vitagliano L
* The dimeric structure of Sulfolobus solfataricus thioredoxin A2 and the basis of its thermostability (436 views)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2009 Dec; 77(4): 1004-1008.
Impact Factor: 3.085
View Export to BibTeX Export to EndNote
D'Ambrosio K, Limauro D, Pedone E, Galdi I, Pedone C, Bartolucci S, De Simone G
* Insights into the catalytic mechanism of the Bcp family: functional and structural analysis of Bcp1 from Sulfolobus solfataricus (539 views)
Proteins (ISSN: 1097-0134, 0887-3585, 1097-0134electronic), 2009 Sep; 76(4): 995-1006.
Impact Factor: 3.085
View Export to BibTeX Export to EndNote
Pennacchio A, Esposito L, Zagari A, Rossi M, Raia CA
* Role of Tryptophan 95 in substrate specificity and structural stability of Sulfolobus solfataricus alcohol dehydrogenase (298 views)
Extremophiles (ISSN: 1431-0651, 1433-4909, 1433-4909electronic), 2009 Sep; 13(5): 751-761.
Impact Factor: 2
View Export to BibTeX Export to EndNote
Ruggiero I, Cantiello P, Lamberti A, Sorrentino A, Martucci NM, Ruggiero A, Arcone R, Vitagliano L, Arcari P, Masullo M
* Biochemical Characterisation Of The D60a Mutant Of The Elongation Factor 1 Alpha From The Archaeon Sulfolobus Solfataricus (324 views)
Biochimie (ISSN: 0300-9084, 1638-6183, 1638-6183electronic), 2009 Jul; 91(7): 835-842.
Impact Factor: 3.897
View Export to BibTeX Export to EndNote
Ruggiero A, Lanzotti MA, Ruocco MR, Grimaldi P, Marasco D, Arcari P, Masullo M, Zagari A, Vitagliano L
* Crystallization and preliminary X-ray crystallographic analysis of two dimeric hyperthermostable thioredoxins isolated from Sulfolobus solfataricus (337 views)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1744-3091, 1744-4309), 2009 Jun; 65: 604-607.
Impact Factor: 0.551
View Export to BibTeX Export to EndNote
Di Fiore A, Fiorentino G, Vitale RM, Ronca R, Amodeo P, Pedone C, Bartolucci S, De Simone G
* Structural analysis of BldR from Sulfolobus solfataricus provides insights into the molecular basis of transcriptional activation in Archaea by MarR family proteins (470 views)
J Mol Biol (ISSN: 1089-8638, 0022-2836, 1089-8638electronic), 2009 May 8; 388(3): 559-569.
Impact Factor: 3.871
View Export to BibTeX Export to EndNote
Ruggiero A, Masullo M, Ruocco MR, Grimaldi P, Lanzotti MA, Arcari P, Zagari A, Vitagliano L
* Structure and stability of a thioredoxin reductase from Sulfolobus solfataricus: A thermostable protein with two functions (347 views)
Bba-Gen Subjects (ISSN: 1570-9639, 0006-3002, 0925-4439), 2009 Mar; 1794(3): 554-562.
Impact Factor: 2.48
View Export to BibTeX Export to EndNote
Francalanci F, Avolio M, De Luca E, Longo DL, Menchise V, Guazzi P, Sgro F, Marino M, Goitre L, Balzac F, Trabalzini L, Retta SF
* Structural and functional differences between KRIT1A and KRIT1B isoforms: A framework for understanding CCM pathogenesis (525 views)
Exp Cell Res (ISSN: 0014-4827), 2009 Jan 15; 315(2): 285-303.
Impact Factor: 3.589
View Export to BibTeX Export to EndNote
Limauro D, Saviano M, Galdi I, Rossi M, Bartolucci S, Pedone E
* Sulfolobus solfataricus protein disulphide oxidoreductase: insight into the roles of its redox sites (236 views)
Protein Engineering Design & Selection (ISSN: 1741-0126), 2009 Jan; 22(1): 19-26.
Impact Factor: 2.596
View Export to BibTeX Export to EndNote
Grimaldi P, Ruocco MR, Lanzotti MA, Ruggiero A, Ruggiero I, Arcari P, Vitagliano L, Masullo M
* Characterisation of the components of the thioredoxin system in the archaeon Sulfolobus solfataricus (370 views)
Extremophiles (ISSN: 1431-0651, 1433-4909, 1433-4909electronic), 2008 Jul; 12(4): 553-562.
Impact Factor: 1.782
View Export to BibTeX Export to EndNote
Limauro D, Pedone E, Galdi I, Bartolucci S
* Peroxiredoxins as cellular guardians in Sulfolobus solfataricus - characterization of Bcp1, Bcp3 and Bcp4 (385 views)
Febs Journal (ISSN: 1742-464x), 2008 May; 275(9): 2067-2077.
Impact Factor: 3.139
View Export to BibTeX Export to EndNote
Granata V, Graziano G, Ruggiero A, Raimo G, Masullo M, Arcari P, Vitagliano L, Zagari A
* Stability Against Temperature Of Sulfolobus Solfataricus Elongation Factor 1 Alpha, A Multi-Domain Protein (380 views)
Bba-Gen Subjects (ISSN: 1570-9639, 0006-3002, 0925-4439), 2008 Apr; 1784(4): 573-581.
Impact Factor: 2.233
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Prato S, Vitale RM, Contursi P, Lipps G, Saviano M, Rossi M, Bartolucci S
* Molecular modeling and functional characterization of the monomeric primase-polymerase domain from the Sulfolobus solfataricus plasmid pIT3 (402 views)
Febs J (ISSN: 1742-464x), 2008; 275(17): 4389-4402.
Impact Factor: 3.139
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Ragno R, Simeoni S, Castellano S, Vicidomini C, Mai A, Caroli A, Tramontano A, Bonaccini C, Trojer P, Bauer I, Brosch G, Sbardella G
* Small molecule inhibitors of histone arginine methyltransferases: Homology modeling, molecular docking, binding mode analysis, and biological evaluations (965 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2007 Mar 22; 50(6): 1241-1253.
Impact Factor: 4.895
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Pedone E, Limauro D, D'Alterio R, Rossi M, Bartolucci S
* Characterization of a multifunctional protein disulfide oxidoreductase from Sulfolobus solfataricus (330 views)
Febs Journal (ISSN: 1742-464x), 2006 Dec; 273(23): 5407-5420.
Impact Factor: 3.033
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Limauro D, Pedone E, Pirone L, Bartolucci S
* Identification and characterization of 1-Cys peroxiredoxin from Sulfolobus solfataricus and its involvement in the response to oxidative stress (378 views)
Febs Journal (ISSN: 1742-464x), 2006 Feb; 273(4): 721-731.
Impact Factor: 3.033
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Granata V, Graziano G, Ruggiero A, Raimo G, Masullo M, Arcari P, Vitagliano L, Zagari A
* Chemical Denaturation Of The Elongation Factor 1 Alpha Isolated From The Hyperthermophilic Archaeon Sulfolobus Solfataricus (358 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2006 Jan 24; 45(3): 719-726.
Impact Factor: 3.633
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Ruggiero A, Masullo M, Arcari P, Raimo G, Vitagliano L, Zagari A
* Crystallization And Preliminary X-Ray Crystallographic Analysis Of The Sulfolobus Solfataricus Nucleotide-Exchange Factor 1 Beta (340 views)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1744-3091, 1744-4309), 2005 Nov; 61(11): 1000-1002.
Impact Factor: 0.568
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Ruggiero A, Ruocco MR, Grimaldi P, Arcari P, Masullo M, Zagari A, Vitagliano L
* Crystallization and preliminary X-ray crystallographic analysis of Sulfolobus solfataricus thioredoxin reductase (319 views)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1744-3091, 1744-4309), 2005 Oct; 61: 906-909.
Impact Factor: 0.568
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Merlino A, Graziano G, Mazzarella L
* Structural And Dynamic Effects Of Alpha-Helix Deletion In Sso7d: Implications For Protein Thermal Stability (423 views)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2004 Dec 1; 57(4): 692-701.
Impact Factor: 4.429
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Vitagliano L, Ruggiero A, Masullo M, Cantiello P, Arcari P, Zagari A
* The Crystal Structure Of Sulfolobus Solfataricus Elongation Factor 1 Alpha In Complex With Magnesium And Gdp (483 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2004; 43(21): 6630-6636.
Impact Factor: 4.008
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Esposito L, Bruno I, Sica F, Raia CA, Giordano A, Rossi M, Mazzarella L, Zagari A
* Crystal structure of a ternary complex of the alcohol dehydrogenase from Sulfolobus solfataricus (545 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2003 Dec 16; 42(49): 14397-14407.
Impact Factor: 3.922
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Esposito L, Bruno I, Sica F, Raia CA, Giordano A, Rossi M, Mazzarella L, Zagari A
* Structural study of a single-point mutant of Sulfolobus solfataricus alcohol dehydrogenase with enhanced activity (313 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 2003 Mar 27; 539(1-3): 14-18.
Impact Factor: 3.609
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Esposito L, Sica F, Raia CA, Giordano A, Rossi M, Mazzarella L, Zagari A
* Crystal Structure Of The Alcohol Dehydrogenase From The Hyperthermophilic Archaeon Sulfolobus Solfataricus At 1. 85 Angstrom Resolution (476 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2002 Apr 26; 318(2): 463-477.
Impact Factor: 5.359
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Masullo M, Cantiello P, Paola B, Fiengo A, Vitagliano L, Zagari A, Arcari P
* Valine114 Replacements In The Archaeal Elongation Factor 1a Enhanced Its Ability To Interact With Aminoacyl-Trna And Kirromycin (353 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2002; 41(49): 14482-14488.
Impact Factor: 4.064
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Vitagliano L, Masullo M, Sica F, Zagari A, Bocchini V
* The crystal structure of Sulfolobus solfataricus elongation factor 1α in complex with GDP reveals novel features in nucleotide binding and exchange (457 views)
Embo J (ISSN: 0261-4189, 0261-4189linking), 2001 Oct 1; 20(19): 5305-5311.
Impact Factor: 12.459
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Esposito L, Sica F, Sorrentino G, Berisio R, Carotenuto L, Giordano A, Raia C, Rossi M, Lamzin VS, Willson KS, Zagari A
Protein Crystal Growth In The Advance Protein Crystallisation Facility On The Lms Mission: A Comparison Of Sulfolobus Solfataricus Alchool Dehydrogenase Crystals Grown On The Ground And In Microgravity (253 views)
Acta Crystallogr D Biol Crystallogr, 1998; 54: 386-390.
Impact Factor: 0
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Esposito L, Sica F, Sorrentino G, Berisio R, Carotenuto L, Giordano A, Raia CA, Rossi M, Lamzin VS, Wilson KS, Zagari A
Protein crystal growth in the advanced protein crystallization facility on the LMS mission: A comparison of Sulfolobus solfataricus alcohol dehydrogenase crystals grown on the ground and in microgravity (433 views)
Acta Crystallogr D Biol Crystallogr (ISSN: 0907-4449, 0907-4449linking), 1998; 54(3): 386-390.
Impact Factor: 2.244
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PEARL L, DEMASI D, HEMMINGS A, SICA F, MAZZARELLA L, RAIA C, DAURIA S, ROSSI M
CRYSTALLIZATION AND PRELIMINARY-X-RAY ANALYSIS OF AN NAD+-DEPENDENT ALCOHOL-DEHYDROGENASE FROM THE EXTREME THERMOPHILIC ARCHAEBACTERIUM SULFOLOBUS-SOLFATARICUS (445 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 1993 Feb 5; 229(3): 782-784.
Impact Factor: 5.673
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42 Records (42 excluding Abstracts).
Total impact factor: 136.564 (136.564 excluding Abstracts).
Total 5 year impact factor: 134.026 (134.026 excluding Abstracts).
Total impact factor: 136.564 (136.564 excluding Abstracts).
Total 5 year impact factor: 134.026 (134.026 excluding Abstracts).
399 views. Last view on Friday 02 June 2023, 3:01:32
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