Growth Hormone Deficiency in Patients with Chronic Heart Failure and Beneficial Effects of Its Correction (821 views)
Journal Of Clinical Endocrinology & Metabolism (ISSN: 0021-972x), 2009 Sep; 94(9): 3329-3336.
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Paper type: Journal Article,
Impact factor: 6.202, 5-year impact factor: 6.46
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Keywords: Amino Terminal Pro Brain Natriuretic Peptide, Human Growth Hormone, Somatomedin C, Absence Of Side Effects, Adult, Article, Blood Vessel Reactivity, Cardiovascular Effect, Clinical Trial, Controlled Clinical Trial, Controlled Study, Disease Marker, Drug Dose Increase, Drug Dose Reduction, Drug Safety, Exercise, Female, Growth Hormone Deficiency, Heart Ejection Fraction, Heart Failure, Heart Left Ventricle Ejection Fraction, Hormone Substitution, Major Clinical Study, Oxygen Consumption, Physical Performance, Prevalence, Priority Journal, Quality Of Life, Randomized Controlled Trial, Single Blind Procedure, United States, Affect, Aged, Exercise Test, Hormone Replacement Therapy, Insulin-Like Growth Factor I, Middle Aged, Peptide Fragments, Single-Blind Method, Ventricular Function,
Affiliations:
*** IBB - CNR ***
Department of Internal Medicine and Cardiovascular Sciences, University Federico II, 80131 Naples, Italy
Department of Radiology, University Federico II, 80131 Naples, Italy
Department of Molecular and Clinical Endocrinology and Oncology, University Federico II, 80131 Naples, Italy
References:
Not available.
Journal Of Clinical Endocrinology & Metabolism (ISSN: 0021-972x), 2009 Sep; 94(9): 3329-3336.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 6.202, 5-year impact factor: 6.46
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-69949126965&partnerID=40&md5=2e07130a437d57f97be4ed102baebb2d
Keywords: Amino Terminal Pro Brain Natriuretic Peptide, Human Growth Hormone, Somatomedin C, Absence Of Side Effects, Adult, Article, Blood Vessel Reactivity, Cardiovascular Effect, Clinical Trial, Controlled Clinical Trial, Controlled Study, Disease Marker, Drug Dose Increase, Drug Dose Reduction, Drug Safety, Exercise, Female, Growth Hormone Deficiency, Heart Ejection Fraction, Heart Failure, Heart Left Ventricle Ejection Fraction, Hormone Substitution, Major Clinical Study, Oxygen Consumption, Physical Performance, Prevalence, Priority Journal, Quality Of Life, Randomized Controlled Trial, Single Blind Procedure, United States, Affect, Aged, Exercise Test, Hormone Replacement Therapy, Insulin-Like Growth Factor I, Middle Aged, Peptide Fragments, Single-Blind Method, Ventricular Function,
Affiliations:
*** IBB - CNR ***
Department of Internal Medicine and Cardiovascular Sciences, University Federico II, 80131 Naples, Italy
Department of Radiology, University Federico II, 80131 Naples, Italy
Department of Molecular and Clinical Endocrinology and Oncology, University Federico II, 80131 Naples, Italy
References:
Not available.
Growth Hormone Deficiency in Patients with Chronic Heart Failure and Beneficial Effects of Its Correction
Context: A reduced activity of the GH/IGF-I axis in chronic heart failure (CHF) has been described by several independent groups and is associated with poor clinical status and outcome. Objective: The aim of the current study was to investigate the prevalence of GH deficiency in a patient population with CHF and evaluate the cardiovascular effects of GH replacement therapy. Design and Setting: The randomized, single-blind, controlled trial was conducted at the Federico II University. Participants: One hundred fifty-eight patients with CHF, New York Heart Association class II-IV, underwent a GH stimulation test. Sixty-three patients satisfied the criteria for GH deficiency, and 56 of them were enrolled in the trial. Intervention: The treated group (n = 28) received GH at a replacement dose of 0.012 mg/kg every second day (similar to 2.5 IU). Main Outcomes Measures: Changes in physical performance and various cardiovascular indexes were measured. Results: GH replacement therapy improved quality of life score (from 46 +/- 5 to 38 +/- 4; P < 0.01), increased peak oxygen uptake and exercise duration (from 12.9 +/-. 9 to 14.5 +/- 1 ml/kg . min and from 520 +/- 36 to 586 +/- 43 sec, respectively; P < 0.01), and flow-mediated vasodilation (from 8.8 +/- 1.3 to 12.7 +/- 1.2%; P < 0.01). GH increased left ventricular ejection fraction (from 34 +/- 2to36 +/- 2%; P < 0.01) and reduced circulating N-terminal pro-brain natriuretic peptide levels (from 3201 +/- 900 to 2177 +/- 720 pg/ml; P = 0.006). No significant changes from baseline were observed in controls. Conclusions: As many as 40% of patients with CHF are GH deficient. GH replacement therapy in these patients improves exercise capacity, vascular reactivity, left ventricular function, and indices of quality of life. (J Clin Endocrinol Metab 94: 3329-3336, 2009)
Context: A reduced activity of the GH/IGF-I axis in chronic heart failure (CHF) has been described by several independent groups and is associated with poor clinical status and outcome. Objective: The aim of the current study was to investigate the prevalence of GH deficiency in a patient population with CHF and evaluate the cardiovascular effects of GH replacement therapy. Design and Setting: The randomized, single-blind, controlled trial was conducted at the Federico II University. Participants: One hundred fifty-eight patients with CHF, New York Heart Association class II-IV, underwent a GH stimulation test. Sixty-three patients satisfied the criteria for GH deficiency, and 56 of them were enrolled in the trial. Intervention: The treated group (n = 28) received GH at a replacement dose of 0.012 mg/kg every second day (similar to 2.5 IU). Main Outcomes Measures: Changes in physical performance and various cardiovascular indexes were measured. Results: GH replacement therapy improved quality of life score (from 46 +/- 5 to 38 +/- 4; P < 0.01), increased peak oxygen uptake and exercise duration (from 12.9 +/-. 9 to 14.5 +/- 1 ml/kg . min and from 520 +/- 36 to 586 +/- 43 sec, respectively; P < 0.01), and flow-mediated vasodilation (from 8.8 +/- 1.3 to 12.7 +/- 1.2%; P < 0.01). GH increased left ventricular ejection fraction (from 34 +/- 2to36 +/- 2%; P < 0.01) and reduced circulating N-terminal pro-brain natriuretic peptide levels (from 3201 +/- 900 to 2177 +/- 720 pg/ml; P = 0.006). No significant changes from baseline were observed in controls. Conclusions: As many as 40% of patients with CHF are GH deficient. GH replacement therapy in these patients improves exercise capacity, vascular reactivity, left ventricular function, and indices of quality of life. (J Clin Endocrinol Metab 94: 3329-3336, 2009)
Growth Hormone Deficiency in Patients with Chronic Heart Failure and Beneficial Effects of Its Correction
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Growth Hormone Deficiency in Patients with Chronic Heart Failure and Beneficial Effects of Its Correction
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View Export to BibTeX Export to EndNote
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View Export to BibTeX Export to EndNote
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View Export to BibTeX Export to EndNote
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Impact Factor: 6.02
View Export to BibTeX Export to EndNote
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J Clin Endocrinol Metab (ISSN: 0021-972x), 2004 Dec; 89(12): 5998-6004.
Impact Factor: 5.778
View Export to BibTeX Export to EndNote
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J Clin Endocrinol Metab (ISSN: 0021-972x), 2003 Sep; 88(9): 4105-4109.
Impact Factor: 5.873
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Colao A, Marzullo P, Cuocolo A, Spinelli L, Pivonello R, Bonaduce D, Salvatore M, Lombardi G
* Reversal of acromegalic cardiomyopathy in young but not in middle-aged patients after 12 months of treatment with the depot long-acting somatostatin analogue octreotide (850 views)
Clin Endocrinol (ISSN: 0300-0664, 1365-2265, 1365-2265electronic), 2003 Feb; 58(2): 169-176.
Impact Factor: 2.767
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Leosco D, Iaccarino G, Cipolletta E, De Santis D, Pisani E, Trimarco V, Ferrara N, Abete P, Sorriento D, Rengo F, Trimarco B
* Exercise restores β-adrenergic vasorelaxation in aged rat carotid arteries (457 views)
Am J Physiol Heart Circ Physiol American Journal Of Physiology Heart And Circulatory Physiology (ISSN: 0363-6135), 2003; 285(154-1): H369-H369.
Impact Factor: 3.658
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Colao A, Spinelli L, Cuocolo A, Spiezia S, Pivonello R, Di Somma C, Bonaduce D, Salvatore M, Lombardi G
* Cardiovascular consequences of early-onset growth hormone excess (577 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2002 Jul; 87(7): 3097-3104.
Impact Factor: 5.199
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Colao A, Di Somma C, Pivonello R, Cuocolo A, Spinelli L, Bonaduce D, Salvatore M, Lombardi G
* The cardiovascular risk of adult GH deficiency (GHD) improved after GH replacement and worsened in untreated GHD: A 12-month prospective study (510 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2002 Mar; 87(3): 1088-1093.
Impact Factor: 5.199
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Colao A, Di Somma C, Cuocolo A, Spinelli L, Tedesco N, Pivonello R, Bonaduce D, Salvatore M, Lombardi G
* Improved cardiovascular risk factors and cardiac performance after 12 months of growth hormone (GH) replacement in young adult patients, with GH deficiency (791 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2001 May; 86(5): 1874-1881.
Impact Factor: 5.16
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Colao A, Cuocolo A, Marzullo P, Nicolai E, Ferone D, Morte A, Pivonello R, Salvatore M, Lombardi G
* Is the acromegalic cardiomyopathy reversible? Effect of 5-year normalization of growth hormone and insulin-like growth factor I levels on cardiac performance (497 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2001 Apr; 86(4): 1551-1557.
Impact Factor: 5.16
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Colao A, Marzullo P, Ferone D, Spinelli L, Cuocolo A, Bonaduce D, Salvatore M, Boerlin V, Lancranjan I, Lombardi G
Cardiovascular effects of depot long-acting somatostatin analog sandostatin LAR in acromegaly (582 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2000 Sep; 85(9): 3132-3140.
Impact Factor: 5.447
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Marzullo P, Cuocolo A, Ferone D, Pivonello R, Salvatore M, Lombardi G, Colao A
Cardiac effect of thyrotoxicosis in acromegaly (685 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2000 Apr; 85(4): 1426-1432.
Impact Factor: 5.447
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Colao A, Cuocolo A, Di Somma C, Cerbone G, Della Morte A, Pivonello R, Nicolai E, Salvatore M, Lombardi G
Does the age of onset of growth hormone deficiency affect cardiac performance? A radionuclide angiography study (719 views)
Clin Endocrinol (ISSN: 0300-0664, 1365-2265, 1365-2265electronic), 2000 Apr; 52(4): 447-455.
Impact Factor: 2.922
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Colao A, Cuocolo A, Di Somma C, Cerbone G, Della Morte A, Nicolai E, Lucci R, Salvatore M, Lombardi G
Impaired cardiac performance in elderly patients with growth hormone deficiency (585 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 1999 Nov; 84(11): 3950-3955.
Impact Factor: 5.805
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Colao A, Cuocolo A, Marzullo P, Nicolai E, Ferone D, Della Morte A, Petretta M, Salvatore M, Lombardi G
Impact of patient's age and disease duration on cardiac performance in acromegaly: A radionuclide angiography study (482 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 1999 May; 84(5): 1518-1523.
Impact Factor: 5.805
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Colao A, Lastoria S, Ferone D, Varrella P, Marzullo P, Pivonello R, Cerbone G, Acampa W, Salvatore M, Lombardi G
The pituitary uptake of In-111-DTPA-D-Phe(1)-octreotide in the normal pituitary and in pituitary adenomas (549 views)
J Endocrinol Invest (ISSN: 0391-4097, 1720-8386electronic), 1999 Mar; 22(3): 176-183.
Impact Factor: 0.957
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Colao A, Cuocolo A, Marzullo P, Nicolai E, Ferone D, Florimonte L, Salvatore M, Lombardi G
Effects of 1-year treatment with octreotide on cardiac performance in patients with acromegaly (608 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 1999 Jan; 84(1): 17-23.
Impact Factor: 5.805
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Ferone D, Lastoria S, Colao A, Varrella P, Cerbone G, Acampa W, Merola B, Salvatore M, Lombardi G
Correlation of scintigraphic results using 123I-methoxybenzamide with hormone levels and tumor size response to quinagolide in patients with pituitary adenomas (489 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 1998 Jan; 83(1): 248-252.
Impact Factor: 5.641
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Lombardi G, Colao A, Cuocolo A, Longobardi S, Di Somma C, Orio F, Merola B, Nicolai E, Salvatore M
Cardiological aspects of growth hormone and insulin-like growth factor- (1144 views)
J Pediatr Endocrinol Metab (ISSN: 0334-018x), 1997 Nov; 10(6): 553-560.
Impact Factor: 0.481
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Pezzino V, Papa V, Trischitta V, Brunetti A, Goodman PA, Treutelaar MK, Williams JA, Maddux BA, Vigneri R, Goldfine ID
Human insulin receptor radioimmunoassay: Applicability to insulin-resistant states (389 views)
Am J Physiol Endocrinol Metab (ISSN: 0002-9513), 1989 Sep; 257(3): N/D-N/D.
Impact Factor: 3.116
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Mancini M, De Chiara S, Ferrara LA, Gallotta G, Postiglione A
TRANSCRANIAL DOPPLER EVALUATION OF CEREBROVASCULAR REACTIVITY TO ACETAZOLAMIDE IN NORMAL SUBJECTS (723 views)
15th World Congress Angiology Rome, 1989; 20(4): 284-284.
Impact Factor: 0
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32 Records (29 excluding Abstracts).
Total impact factor: 150.66 (143.869 excluding Abstracts).
Total 5 year impact factor: 115.47 (115.47 excluding Abstracts).
Total impact factor: 150.66 (143.869 excluding Abstracts).
Total 5 year impact factor: 115.47 (115.47 excluding Abstracts).
821 views. Last view on Sunday 01 December 2024, 2:36:52
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