In vitro autoradiography and in vivo evaluation in cynomolgus monkey of [18F]FE-PE2I, a new dopamine transporter PET radioligand(520 views) Varrone A, Steiger C, Schou M, Takano A, Finnema SJ, Guilloteau D, Gulyas B, Halldin C
Keywords: Dopamine Transporter (dat), Kinetics, Metabolism, Midbrain, Substantia Nigra, [2 Beta Carbomethoxy 3 Beta (4 Fluorophenyl) 8 (2 Fluoroethyl) Nortropane] F 18, Beta Carboxymethoxy 3 Beta (4 Iodophenyltropane), Citalopram, Maprotiline, Radioligand, Tracer, Unclassified Drug, Vanoxerine, Animal Experiment, Animal Tissue, Article, Autoradiography, Caudate Nucleus, Cerebellum, Controlled Study, Corpus Striatum, Drug Binding, Drug Elimination, Drug Metabolism, Drug Uptake, Human, Human Tissue, In Vitro Study, In Vivo Study, Ligand Binding, Mesencephalon, Methodology, Monkey, Neocortex, Nonhuman, Positron Emission Tomography, Priority Journal, Putamen, Quantitative Analysis, Rodent, Thalamus, Competitive, Dopamine Plasma Membrane Transport Proteins, Dopamine Uptake Inhibitors, Dose-Response Relationship, Macaca Fascicularis, Metabolic Clearance Rate, Piperazines, Positron-Emission Tomography, Postmortem Changes, Protein Binding, Radiopharmaceuticals, Serotonin Uptake Inhibitors, Tissue Distribution,
Affiliations: *** IBB - CNR ***
Karolinska Institutet, Department of Clinical Neuroscience, Karolinska Hospital, SE-17176, Stockholm, Sweden
Stockholm Brain Institute, Stockholm, Sweden
Inserm U930, Université François Rabelais de Tours, Tours, France
Medicinal Chemistry AstraZeneca R and D, Södertäljie, Sweden
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Carroll, F. I., Kotian, P., Dehghani, A., Gray, J. L., Kuzemko, M. A., Parham, K. A., Abraham, P., Kuhar, M. J., Cocaine and 3 beta- (4 -substituted phenyl) tropane-2 beta-carboxylic acid ester and amide analogues. New high-affinity and selective compounds for the dopamine transporter (1995) J Med Chem, 38, pp. 379-388
Clark, J. D., Gebhart, G. F., Gonder, J. C., Keeling, M. E., Kohn, D. F., Special report: The 1996 guide for the care and use of laboratory animals (1997) Ilar J, 38, pp. 41-48
Innis, R. B., Cunningham, V. J., Delforge, J., Fujita, M., Gjedde, A., Gunn, R. N., Holden, J., Carson, R. E., Consensus nomenclature for in vivo imaging of reversibly binding radioligands (2007) Journal of Cerebral Blood Flow and Metabolism, 27 (9), pp. 1533-1539. , DOI 10. 1038/sj. jcbfm. 9600493, PII 9600493
Kuikka, J. T., Baulieu, J. L., Hiltunen, J., Halldin, C., Bergstrom, K. A., Farde, L., Emond, P., Guilloteau, D., Pharmacokinetics and dosimetry of iodine-123 labelled PE2I in humans, a radioligand for dopamine transporter imaging (1998) European Journal of Nuclear Medicine, 25 (5), pp. 531-534. , DOI 10. 1007/s002590050254
Lammertsma, A. A., Hume, S. P., Simplified reference tissue model for PET receptor studies (1996) NeuroImage, 4 (3), pp. 153-158. , DOI 10. 1006/nimg. 1996. 0066
Melchitzky, D. S., Lewis, D. A., Tyrosine hydroxylase- And dopamine transporter-immunoreactive axons in the primate cerebellum. Evidence for a lobular- and laminar-specific dopamine innervation (2000) Neuropsychopharmacology, 22, pp. 466-472
Owens, M. J., Knight, D. L., Nemeroff, C. B., Second-generation SSRIs: Human monoamine transporter binding profile of escitalopram and R-fluoxetine (2001) Biol Psychiatry, 50, pp. 345-350
Rinne, J. O., Ruottinen, H., Bergman, J., Haaparanta, M., Sonninen, P., Solin, O., Usefulness of a dopamine transporter PET ligand [(18) F] beta-CFT in assessing disability in Parkinson's disease (1999) J Neurol Neurosurg Psychiatry, 67, pp. 737-741
Shetty, H. U., Zoghbi, S. S., Liow, J. -S., Ichise, M., Hong, J., Musachio, J. L., Halldin, C., Pike, V. W., Identification and regional distribution in rat brain of radiometabolites of the dopamine transporter PET radioligand [11C] PE2I (2007) European Journal of Nuclear Medicine and Molecular Imaging, 34 (5), pp. 667-678. , DOI 10. 1007/s00259-006-0277-1
Zoghbi, S. S., Shetty, H. U., Ichise, M., Fujita, M., Imaizumi, M., Liow, J. -S., Shah, J., Innis, R. B., PET imaging of the dopamine transporter with18F-FECNT: A polar radiometabolite confounds brain radioligand measurements (2006) Journal of Nuclear Medicine, 47 (3), pp. 520-527
In vitro autoradiography and in vivo evaluation in cynomolgus monkey of [18F]FE-PE2I, a new dopamine transporter PET radioligand
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