Micelles obtained by aggregation of gemini surfactants containing the CCK8 peptide and a gadolinium complex (398 views)
J Biol Inorg Chem (ISSN: 0949-8257, 1432-1327electronic, 0949-8257linking), 2009 May; 14(4): 587-599.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 3.415, 5-year impact factor: 3.533
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-67349182328&partnerID=40&md5=4f8b53d13714fb99ae7fe465b22bc510
Keywords: Amphiphilic Gadolinium Complexes, Cck8 Peptide, Micelles, Peptide Gemini Surfactant, Small-Angle Neutron Scattering, Chelating Agent, Cholecystokinin, Contrast Medium, Cysteine, Unclassified Drug, Article, Beta Sheet, Chemical Structure, Circular Dichroism, Concentration (parameters), Conformational Transition, Controlled Study, Disulfide Bond, Fluorescence Spectroscopy, Lipophilicity, Molecular Size, Nuclear Magnetic Resonance Imaging, Priority Journal, Temperature, Molecular Structure, Biomolecular, Peptide Fragments, Protein Conformation, Surface-Active Agents,
Affiliations:
*** IBB - CNR ***
Department of Biological Sciences and IBB CNR, CIRPeB, University of Naples Federico II, Via Mezzocannone 16, 80134 Naples, Italy
Department of Chemistry CSGI, Consorzio Interuniversitario per Lo Sviluppo dei Sistemi A Grande Interfase, University of Naples Federico II, Via Cynthia, 80126 Naples, Italy
ISIS-CLRC, Rutherford Appleton Laboratory, Chilton, Oxfordshire OX11 0QX, United Kingdom
References:
Caravan, P., Ellison, J., Lauffer, R., (1999) Chem Rev, 99, pp. 2293-235
Meade, T.J., Taylor, A.K., Bull, S.R., (2003) Curr Opin Neurobiol, 13, pp. 597-602
Toth, E., Helm, L., Merbach, A.E., (2001) The Chemistry of Contrast Agents in Medical Magnetic Resonance Imaging, 1st Edn., pp. 45-120. , Wiley, London
Aime, S., Botta, M., Fasano, M., Terreno, E., (1998) Chem Soc Rev, 27, pp. 19-29
Weinmann, H.J., (2000) Methods in Biomedical Magnetic Resonance. Imaging and Spectroscopy, , Wiley, Chichester
Banci, L., Bertini, I., Luchinat, C., (1991) Nuclear and Electronic Relaxation, , VCH, Weinheim
Laus, S., Sour, A., Ruloff, R., Toth, E., Merbach, A.E., (2005) Chem Eur J, 11, pp. 3064-3076
Nasongkla, N., Bey, E., Ren, J., Ai, H., Khemtong, C., Guthi, J.S., Chin, S.-F., Gao, J., (2006) Nano Lett, 6, pp. 2427-2430
Dirksen, A., Langereis, S., De Waal, B.F.M., Van Genderen, M.H.P., Hackeng, T.M., Meijer, E.W., (2005) Chem Commun, pp. 2811-2813
Toth, E., Bolskar, R.D., Borel, A., Gonzalez, G., Helm, L., Merbach, A.E., Sitharaman, B., Wilson, L.J., (2005) J Am Chem Soc, 127, pp. 799-805
Accardo, A., Tesauro, D., Roscigno, P., Gianolio, E., Paduano, L., D'Errico, G., Pedone, C., Morelli, G., (2004) J Am Chem Soc, 126, pp. 3097-3107
Gløgård, C., Stensrud, G., Hovland, R., Fossheim, S.L., Klaveness, J., (2002) Int J Pharm, 233, pp. 131-140
Nasongkla, N., Shuai, X., Ai, H., Weinberg, B.D., Pink, J., Boothman, D.A., Gao, J., (2004) Angew Chem Int Ed, 43, pp. 6323-6327
Li, K., Bednarski, M.D., (2002) J Magn Reson Imaging, 16, pp. 388-393
Reubi, J.C., (2003) Endocr Rev, 24, pp. 389-427
Tesauro, D., Accardo, A., Gianolio, E., Paduano, L., Teixeira, J., Schillen, K., Aime, S., Morelli, G., (2007) Chembiochem, 8, pp. 950-955
Vaccaro, M., Mangiapia, G., Paduano, L., Gianolio, E., Accardo, A., Tesauro, D., Morelli, G., (2007) Chemphyschem, 8, pp. 2526-2538
Wank, S.A., (1995) Am J Physiol Gastrointest Liver Physiol, 269, pp. 628-G646
Menger, F.M., Littau, C.A., (1991) J Am Chem Soc, 113, pp. 1451-1452
Zana, R., (2002) Adv Colloid Interface Sci, 97, pp. 205-253
Jennings, K., Marshall, I., Birrell, H., Edwards, A., Haskins, N., Sodermann, O., Kirby, A.J., Camilleri, P., (1998) Chem Commun, 18, pp. 1951-1952
Camilleri, P., Kremer, A., Edwards, A.J., Jennings, K.H., Jenkins, O., Marshall, I., McGregor, C., Kirby, A.J., (2000) Chem Commun, 14, pp. 1253-1254
Ronsin, G., Kirby, A.J., Rittenhouse, S., Woodnutt, G., Camilleri, P.J., (2002) Chem Soc Perkin Trans, 2, pp. 1302-1306
Lowik, D.W., Garcia-Hartjes, J., Meijer, J.T., Van Hest, J.C.M., (2005) Langmuir, 21, pp. 524-526
Hamley, I.W., Ansari, I.A., Castelletto, V., Nuhn, H., Rosler, A., Klok, H.A., (2005) Biomacromolecules, 6, pp. 1310-1315
Gorski, N., Kalus, J., (2001) Langmuir, 17, pp. 4211-4215
Bott, R., Wolff, T., Zierold, K., (2002) Langmuir, 18, pp. 2004-2012
Chang, W.C., White, P.D., (2000) Fmoc Solid Phase Peptide Synthesis, , Oxford University Press, New York
Ellmann, G.L., (1959) Arch Biochem Biophys, 82, pp. 70-77
Barge, A., Cravotto, G., Gianolio, E., Fedeli, F., (2006) Contrast Med Mol Imaging, 1, pp. 184-188
Diwu, Z., Lu, Y., Zhang, C., Klaubert, D.H., Haugland, R.P., (1997) Photochem Photobiol, 66, pp. 424-431
Menger, F.M., (1979) Acc Chem Res, 12, pp. 111-117
Zana, R., (2002) Langmuir, 18 (20), pp. 7759-7760
Menger, F.M., Jerkumica, J.M., Jhonston, J.C., (1978) J Am Chem Soc, 100, pp. 4676-4678
Mangiapia, G., Accardo, A., Lo Celso, F., Tesauro, D., Morelli, G., Radulescu, A., Paduano, L., (2004) J Phys Chem B, 108, pp. 17611-17617
Underfriend, S., Meienhofer, J., (1985) The Peptides, 7. , IHruby VJ (ed) Academic Press, New York
Pellegrini, M., Mierke, D.F., (1999) Biochemistry, 38, pp. 14775-14783
Moroder, L., D'Ursi, A., Picone, D., Amodeo, P., Temussi, P.A., (1993) Biochem Biophys Res Commun, 190 (3), pp. 741-746
Radulescu, A., Mathers, R.T., Coates, G.W., Richter, D., Fetters, L., (2004) Macromolecules, 37, pp. 6962-6971
Kotlarchyk, M., Chen, S.H., (1983) J Chem Phys, 79, pp. 2461-2469
Nicolle, G.M., Toth, E., Eisenwiener, K.P., MacKe, H.R., Merbach, A.E., (2002) J Biol Inorg Chem, 7, pp. 757-769
Delli Castelli, D., Gianolio, E., Geninatti Crich, S., Terreno, E., Aime, S., (2008) Coord Chem Rev, 252, pp. 2424-2443
Powell, D.H., Ni Dhubhghaill, O.M., Pubanz, D., Helm, L., Lebedev, Y.S., Schlaepfer, V., Merbach, A.E., (1996) J Am Chem Soc, 118, pp. 9333-9346
Lipari, G., Szabo, A., (1982) J Am Chem Soc, 104, pp. 4546-4559
Nicolle, G.M., Helm, L., Merbach, A.E., (2003) Magn Reson Chem, 41, pp. 794-799
Torchilin, V.P., (2005) Nat Rev Drug Discov, 4, pp. 145-154
Rjmge, B., Mulder, W.J.M., Nicolay, K., Mayo, K.H., Vljl, T., Griffioen, A.W., (2007) Bioconjug Chem, 18, pp. 785-792
Reubi, J.C., Schaer, J.C., Waser, B., (1997) Cancer Res, 57, pp. 1377-1386
Anelli, P.L., Fedeli, F., Gazzotti, O., Lattuada, L., Lux, G., Rebasti, F., (1999) Bioconjug Chem, 10, pp. 137-140
Edelhoch, H., (1967) Biochemistry, 6, pp. 1948-1954
Pace, C.N., Vajdos, F., Fee, L., Grimsley, G., Gray, T., (1995) Protein Sci, 4, pp. 2411-2423
Birdi, K.S., Singh, H.N., Dalsager, S.U., (1979) J Phys Chem, 83, pp. 2733-2737
De Vendittis, E., Palumbo, G., Parlato, G., Bocchini, V., (1981) Anal Biochem, 115, pp. 278-286
Heenan, R.K., Penfold, J., King, S.M., (1997) J Appl Crystallogr, 30, pp. 1140-1147
Meade, T. J., Taylor, A. K., Bull, S. R., (2003) Curr Opin Neurobiol, 13, pp. 597-602
Weinmann, H. J., (2000) Methods in Biomedical Magnetic Resonance. Imaging and Spectroscopy, , Wiley, Chichester
Gl g rd, C., Stensrud, G., Hovland, R., Fossheim, S. L., Klaveness, J., (2002) Int J Pharm, 233, pp. 131-140
Reubi, J. C., (2003) Endocr Rev, 24, pp. 389-427
Wank, S. A., (1995) Am J Physiol Gastrointest Liver Physiol, 269, pp. 628-G646
Menger, F. M., Littau, C. A., (1991) J Am Chem Soc, 113, pp. 1451-1452
Lowik, D. W., Garcia-Hartjes, J., Meijer, J. T., Van Hest, J. C. M., (2005) Langmuir, 21, pp. 524-526
Hamley, I. W., Ansari, I. A., Castelletto, V., Nuhn, H., Rosler, A., Klok, H. A., (2005) Biomacromolecules, 6, pp. 1310-1315
Chang, W. C., White, P. D., (2000) Fmoc Solid Phase Peptide Synthesis, , Oxford University Press, New York
Ellmann, G. L., (1959) Arch Biochem Biophys, 82, pp. 70-77
Menger, F. M., (1979) Acc Chem Res, 12, pp. 111-117
Menger, F. M., Jerkumica, J. M., Jhonston, J. C., (1978) J Am Chem Soc, 100, pp. 4676-4678
Nicolle, G. M., Toth, E., Eisenwiener, K. P., MacKe, H. R., Merbach, A. E., (2002) J Biol Inorg Chem, 7, pp. 757-769
Powell, D. H., Ni Dhubhghaill, O. M., Pubanz, D., Helm, L., Lebedev, Y. S., Schlaepfer, V., Merbach, A. E., (1996) J Am Chem Soc, 118, pp. 9333-9346
Nicolle, G. M., Helm, L., Merbach, A. E., (2003) Magn Reson Chem, 41, pp. 794-799
Torchilin, V. P., (2005) Nat Rev Drug Discov, 4, pp. 145-154
Reubi, J. C., Schaer, J. C., Waser, B., (1997) Cancer Res, 57, pp. 1377-1386
Anelli, P. L., Fedeli, F., Gazzotti, O., Lattuada, L., Lux, G., Rebasti, F., (1999) Bioconjug Chem, 10, pp. 137-140
Pace, C. N., Vajdos, F., Fee, L., Grimsley, G., Gray, T., (1995) Protein Sci, 4, pp. 2411-2423
Birdi, K. S., Singh, H. N., Dalsager, S. U., (1979) J Phys Chem, 83, pp. 2733-2737
Heenan, R. K., Penfold, J., King, S. M., (1997) J Appl Crystallogr, 30, pp. 1140-1147
J Biol Inorg Chem (ISSN: 0949-8257, 1432-1327electronic, 0949-8257linking), 2009 May; 14(4): 587-599.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 3.415, 5-year impact factor: 3.533
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-67349182328&partnerID=40&md5=4f8b53d13714fb99ae7fe465b22bc510
Keywords: Amphiphilic Gadolinium Complexes, Cck8 Peptide, Micelles, Peptide Gemini Surfactant, Small-Angle Neutron Scattering, Chelating Agent, Cholecystokinin, Contrast Medium, Cysteine, Unclassified Drug, Article, Beta Sheet, Chemical Structure, Circular Dichroism, Concentration (parameters), Conformational Transition, Controlled Study, Disulfide Bond, Fluorescence Spectroscopy, Lipophilicity, Molecular Size, Nuclear Magnetic Resonance Imaging, Priority Journal, Temperature, Molecular Structure, Biomolecular, Peptide Fragments, Protein Conformation, Surface-Active Agents,
Affiliations:
*** IBB - CNR ***
Department of Biological Sciences and IBB CNR, CIRPeB, University of Naples Federico II, Via Mezzocannone 16, 80134 Naples, Italy
Department of Chemistry CSGI, Consorzio Interuniversitario per Lo Sviluppo dei Sistemi A Grande Interfase, University of Naples Federico II, Via Cynthia, 80126 Naples, Italy
ISIS-CLRC, Rutherford Appleton Laboratory, Chilton, Oxfordshire OX11 0QX, United Kingdom
References:
Caravan, P., Ellison, J., Lauffer, R., (1999) Chem Rev, 99, pp. 2293-235
Meade, T.J., Taylor, A.K., Bull, S.R., (2003) Curr Opin Neurobiol, 13, pp. 597-602
Toth, E., Helm, L., Merbach, A.E., (2001) The Chemistry of Contrast Agents in Medical Magnetic Resonance Imaging, 1st Edn., pp. 45-120. , Wiley, London
Aime, S., Botta, M., Fasano, M., Terreno, E., (1998) Chem Soc Rev, 27, pp. 19-29
Weinmann, H.J., (2000) Methods in Biomedical Magnetic Resonance. Imaging and Spectroscopy, , Wiley, Chichester
Banci, L., Bertini, I., Luchinat, C., (1991) Nuclear and Electronic Relaxation, , VCH, Weinheim
Laus, S., Sour, A., Ruloff, R., Toth, E., Merbach, A.E., (2005) Chem Eur J, 11, pp. 3064-3076
Nasongkla, N., Bey, E., Ren, J., Ai, H., Khemtong, C., Guthi, J.S., Chin, S.-F., Gao, J., (2006) Nano Lett, 6, pp. 2427-2430
Dirksen, A., Langereis, S., De Waal, B.F.M., Van Genderen, M.H.P., Hackeng, T.M., Meijer, E.W., (2005) Chem Commun, pp. 2811-2813
Toth, E., Bolskar, R.D., Borel, A., Gonzalez, G., Helm, L., Merbach, A.E., Sitharaman, B., Wilson, L.J., (2005) J Am Chem Soc, 127, pp. 799-805
Accardo, A., Tesauro, D., Roscigno, P., Gianolio, E., Paduano, L., D'Errico, G., Pedone, C., Morelli, G., (2004) J Am Chem Soc, 126, pp. 3097-3107
Gløgård, C., Stensrud, G., Hovland, R., Fossheim, S.L., Klaveness, J., (2002) Int J Pharm, 233, pp. 131-140
Nasongkla, N., Shuai, X., Ai, H., Weinberg, B.D., Pink, J., Boothman, D.A., Gao, J., (2004) Angew Chem Int Ed, 43, pp. 6323-6327
Li, K., Bednarski, M.D., (2002) J Magn Reson Imaging, 16, pp. 388-393
Reubi, J.C., (2003) Endocr Rev, 24, pp. 389-427
Tesauro, D., Accardo, A., Gianolio, E., Paduano, L., Teixeira, J., Schillen, K., Aime, S., Morelli, G., (2007) Chembiochem, 8, pp. 950-955
Vaccaro, M., Mangiapia, G., Paduano, L., Gianolio, E., Accardo, A., Tesauro, D., Morelli, G., (2007) Chemphyschem, 8, pp. 2526-2538
Wank, S.A., (1995) Am J Physiol Gastrointest Liver Physiol, 269, pp. 628-G646
Menger, F.M., Littau, C.A., (1991) J Am Chem Soc, 113, pp. 1451-1452
Zana, R., (2002) Adv Colloid Interface Sci, 97, pp. 205-253
Jennings, K., Marshall, I., Birrell, H., Edwards, A., Haskins, N., Sodermann, O., Kirby, A.J., Camilleri, P., (1998) Chem Commun, 18, pp. 1951-1952
Camilleri, P., Kremer, A., Edwards, A.J., Jennings, K.H., Jenkins, O., Marshall, I., McGregor, C., Kirby, A.J., (2000) Chem Commun, 14, pp. 1253-1254
Ronsin, G., Kirby, A.J., Rittenhouse, S., Woodnutt, G., Camilleri, P.J., (2002) Chem Soc Perkin Trans, 2, pp. 1302-1306
Lowik, D.W., Garcia-Hartjes, J., Meijer, J.T., Van Hest, J.C.M., (2005) Langmuir, 21, pp. 524-526
Hamley, I.W., Ansari, I.A., Castelletto, V., Nuhn, H., Rosler, A., Klok, H.A., (2005) Biomacromolecules, 6, pp. 1310-1315
Gorski, N., Kalus, J., (2001) Langmuir, 17, pp. 4211-4215
Bott, R., Wolff, T., Zierold, K., (2002) Langmuir, 18, pp. 2004-2012
Chang, W.C., White, P.D., (2000) Fmoc Solid Phase Peptide Synthesis, , Oxford University Press, New York
Ellmann, G.L., (1959) Arch Biochem Biophys, 82, pp. 70-77
Barge, A., Cravotto, G., Gianolio, E., Fedeli, F., (2006) Contrast Med Mol Imaging, 1, pp. 184-188
Diwu, Z., Lu, Y., Zhang, C., Klaubert, D.H., Haugland, R.P., (1997) Photochem Photobiol, 66, pp. 424-431
Menger, F.M., (1979) Acc Chem Res, 12, pp. 111-117
Zana, R., (2002) Langmuir, 18 (20), pp. 7759-7760
Menger, F.M., Jerkumica, J.M., Jhonston, J.C., (1978) J Am Chem Soc, 100, pp. 4676-4678
Mangiapia, G., Accardo, A., Lo Celso, F., Tesauro, D., Morelli, G., Radulescu, A., Paduano, L., (2004) J Phys Chem B, 108, pp. 17611-17617
Underfriend, S., Meienhofer, J., (1985) The Peptides, 7. , IHruby VJ (ed) Academic Press, New York
Pellegrini, M., Mierke, D.F., (1999) Biochemistry, 38, pp. 14775-14783
Moroder, L., D'Ursi, A., Picone, D., Amodeo, P., Temussi, P.A., (1993) Biochem Biophys Res Commun, 190 (3), pp. 741-746
Radulescu, A., Mathers, R.T., Coates, G.W., Richter, D., Fetters, L., (2004) Macromolecules, 37, pp. 6962-6971
Kotlarchyk, M., Chen, S.H., (1983) J Chem Phys, 79, pp. 2461-2469
Nicolle, G.M., Toth, E., Eisenwiener, K.P., MacKe, H.R., Merbach, A.E., (2002) J Biol Inorg Chem, 7, pp. 757-769
Delli Castelli, D., Gianolio, E., Geninatti Crich, S., Terreno, E., Aime, S., (2008) Coord Chem Rev, 252, pp. 2424-2443
Powell, D.H., Ni Dhubhghaill, O.M., Pubanz, D., Helm, L., Lebedev, Y.S., Schlaepfer, V., Merbach, A.E., (1996) J Am Chem Soc, 118, pp. 9333-9346
Lipari, G., Szabo, A., (1982) J Am Chem Soc, 104, pp. 4546-4559
Nicolle, G.M., Helm, L., Merbach, A.E., (2003) Magn Reson Chem, 41, pp. 794-799
Torchilin, V.P., (2005) Nat Rev Drug Discov, 4, pp. 145-154
Rjmge, B., Mulder, W.J.M., Nicolay, K., Mayo, K.H., Vljl, T., Griffioen, A.W., (2007) Bioconjug Chem, 18, pp. 785-792
Reubi, J.C., Schaer, J.C., Waser, B., (1997) Cancer Res, 57, pp. 1377-1386
Anelli, P.L., Fedeli, F., Gazzotti, O., Lattuada, L., Lux, G., Rebasti, F., (1999) Bioconjug Chem, 10, pp. 137-140
Edelhoch, H., (1967) Biochemistry, 6, pp. 1948-1954
Pace, C.N., Vajdos, F., Fee, L., Grimsley, G., Gray, T., (1995) Protein Sci, 4, pp. 2411-2423
Birdi, K.S., Singh, H.N., Dalsager, S.U., (1979) J Phys Chem, 83, pp. 2733-2737
De Vendittis, E., Palumbo, G., Parlato, G., Bocchini, V., (1981) Anal Biochem, 115, pp. 278-286
Heenan, R.K., Penfold, J., King, S.M., (1997) J Appl Crystallogr, 30, pp. 1140-1147
Meade, T. J., Taylor, A. K., Bull, S. R., (2003) Curr Opin Neurobiol, 13, pp. 597-602
Weinmann, H. J., (2000) Methods in Biomedical Magnetic Resonance. Imaging and Spectroscopy, , Wiley, Chichester
Gl g rd, C., Stensrud, G., Hovland, R., Fossheim, S. L., Klaveness, J., (2002) Int J Pharm, 233, pp. 131-140
Reubi, J. C., (2003) Endocr Rev, 24, pp. 389-427
Wank, S. A., (1995) Am J Physiol Gastrointest Liver Physiol, 269, pp. 628-G646
Menger, F. M., Littau, C. A., (1991) J Am Chem Soc, 113, pp. 1451-1452
Lowik, D. W., Garcia-Hartjes, J., Meijer, J. T., Van Hest, J. C. M., (2005) Langmuir, 21, pp. 524-526
Hamley, I. W., Ansari, I. A., Castelletto, V., Nuhn, H., Rosler, A., Klok, H. A., (2005) Biomacromolecules, 6, pp. 1310-1315
Chang, W. C., White, P. D., (2000) Fmoc Solid Phase Peptide Synthesis, , Oxford University Press, New York
Ellmann, G. L., (1959) Arch Biochem Biophys, 82, pp. 70-77
Menger, F. M., (1979) Acc Chem Res, 12, pp. 111-117
Menger, F. M., Jerkumica, J. M., Jhonston, J. C., (1978) J Am Chem Soc, 100, pp. 4676-4678
Nicolle, G. M., Toth, E., Eisenwiener, K. P., MacKe, H. R., Merbach, A. E., (2002) J Biol Inorg Chem, 7, pp. 757-769
Powell, D. H., Ni Dhubhghaill, O. M., Pubanz, D., Helm, L., Lebedev, Y. S., Schlaepfer, V., Merbach, A. E., (1996) J Am Chem Soc, 118, pp. 9333-9346
Nicolle, G. M., Helm, L., Merbach, A. E., (2003) Magn Reson Chem, 41, pp. 794-799
Torchilin, V. P., (2005) Nat Rev Drug Discov, 4, pp. 145-154
Reubi, J. C., Schaer, J. C., Waser, B., (1997) Cancer Res, 57, pp. 1377-1386
Anelli, P. L., Fedeli, F., Gazzotti, O., Lattuada, L., Lux, G., Rebasti, F., (1999) Bioconjug Chem, 10, pp. 137-140
Pace, C. N., Vajdos, F., Fee, L., Grimsley, G., Gray, T., (1995) Protein Sci, 4, pp. 2411-2423
Birdi, K. S., Singh, H. N., Dalsager, S. U., (1979) J Phys Chem, 83, pp. 2733-2737
Heenan, R. K., Penfold, J., King, S. M., (1997) J Appl Crystallogr, 30, pp. 1140-1147
Micelles obtained by aggregation of gemini surfactants containing the CCK8 peptide and a gadolinium complex
Two gemini surfactants, [C18CysL5CCK8]2 and [C18CysDTPAGlu] 2, containing, respectively, the CCK8 peptide and the DTPAGlu chelating agent or its gadolinium complex have been prepared by linking lipophilic chains through a disulfide bond between two cysteine residues. The two surfactants aggregate in water solution forming pure or mixed micelles, with a critical micellar concentration in the 5 × 10-6-5 × 10-5 mol kg-1 range, as measured by fluorescence spectroscopy. As indicated by small-angle neutron scattering, the shape and size of the micelles are influenced by the temperature: increasing temperature leads to progressive reduction of the size of the supramolecular aggregates. Cylindrical structures found at lower temperatures (10-40 °C) evolve into ellipsoidal micelles at 50-80 °C. Furthermore, the surface-exposed CCK8 peptide changes its conformation above a transition temperature of approximately 45 °C, going from a β-sheet to a random-coil structure, as indicated by circular dichroism measurements. The mixed aggregate obtained by coaggregation of the two gemini-based amphiphilic compounds, [C18CysDTPAGlu(Gd)]2 and [C18CysL5CCK8]2 in 70:30 molar ratio, represents the first example of a peptide-containing gemini surfactant as a potential target-selective contrast agent in MRI. In fact, it presents a high relaxivity value of the gadolinium complex, 21.5 mM-1 s -1, and the CCK8 bioactive peptide exposed on the external surface is therefore capable of selective targeting of the cholecystokinin receptors. © 2009 SBIC.
Two gemini surfactants, [C18CysL5CCK8]2 and [C18CysDTPAGlu] 2, containing, respectively, the CCK8 peptide and the DTPAGlu chelating agent or its gadolinium complex have been prepared by linking lipophilic chains through a disulfide bond between two cysteine residues. The two surfactants aggregate in water solution forming pure or mixed micelles, with a critical micellar concentration in the 5 × 10-6-5 × 10-5 mol kg-1 range, as measured by fluorescence spectroscopy. As indicated by small-angle neutron scattering, the shape and size of the micelles are influenced by the temperature: increasing temperature leads to progressive reduction of the size of the supramolecular aggregates. Cylindrical structures found at lower temperatures (10-40 °C) evolve into ellipsoidal micelles at 50-80 °C. Furthermore, the surface-exposed CCK8 peptide changes its conformation above a transition temperature of approximately 45 °C, going from a β-sheet to a random-coil structure, as indicated by circular dichroism measurements. The mixed aggregate obtained by coaggregation of the two gemini-based amphiphilic compounds, [C18CysDTPAGlu(Gd)]2 and [C18CysL5CCK8]2 in 70:30 molar ratio, represents the first example of a peptide-containing gemini surfactant as a potential target-selective contrast agent in MRI. In fact, it presents a high relaxivity value of the gadolinium complex, 21.5 mM-1 s -1, and the CCK8 bioactive peptide exposed on the external surface is therefore capable of selective targeting of the cholecystokinin receptors. © 2009 SBIC.
Micelles obtained by aggregation of gemini surfactants containing the CCK8 peptide and a gadolinium complex
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Micelles obtained by aggregation of gemini surfactants containing the CCK8 peptide and a gadolinium complex
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Lanza V, Milardi D, Di Natale G, Pappalardo G
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Curr Med Chem (ISSN: 1875-533xelectronic, 0929-8673linking), 2018 Feb 12; 25(4): 525-539.
Impact Factor: 3.249
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Barresi V, Spampinato G, Musso N, Trovato Salinaro A, Rizzarelli E, Condorelli DF
* ATOX1 gene silencing increases susceptibility to anticancer therapy based on copper ionophores or chelating drugs (719 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2016; 156: 145-152.
Impact Factor: 3.348
View Export to BibTeX Export to EndNote
Nardon C, Boscutti G, Dalla Via L, Ringhieri P, Di Noto V, Morelli G, Accardo A, Fregona D
* CCK8 peptide-labeled Pluronic® F127 micelles as a targeted vehicle of gold-based anticancer chemotherapeutics (408 views)
Medchemcomm (ISSN: 2040-2503), 2015; 6(1): 155-163.
Impact Factor: 2.319
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Accardo A, Ringhieri P, Szekely N, Pipich V, Luchini A, Paduano L, Tesauro D
* Structural insights on nanoparticles containing gadolinium complexes as potential theranostic (454 views)
Colloid Polym Sci (ISSN: 0303-402x), 2014 May; 292(5): 1121-1127.
Impact Factor: 1.865
View Export to BibTeX Export to EndNote
Grasso GI, Arena G, Bellia F, Rizzarelli E, Vecchio G
* Copper(II)-chelating homocarnosine glycoconjugate as a new multifunctional compound (560 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2014 Feb; 131: 56-63.
Impact Factor: 3.444
View Export to BibTeX Export to EndNote
Calce E, Monfregola L, De Luca S
* Synthetic Strategy to Prepare DOTA-Based Bifunctional Chelating Agent Ready to Bind Biomolecular Probes (460 views)
Int J Pept Res Ther (ISSN: 1573-3149, 0929-5666), 2013 Sep; 19(3): 199-202.
Impact Factor: 0.825
View Export to BibTeX Export to EndNote
Accardo A, Gianolio E, Arena F, Barnert S, Schubert R, Tesauro D, Morelli G
* Nanostructures based on monoolein or diolein and amphiphilic gadolinium complexes as MRI contrast agents (412 views)
J Mater Chem B (ISSN: 2050-7518, 2050-750x), 2013; 1(5): 617-628.
Impact Factor: 8.535
View Export to BibTeX Export to EndNote
Di Fiore A, Maresca A, Supuran CT, De Simone G
* Hydroxamate represents a versatile zinc binding group for the development of new carbonic anhydrase inhibitors (361 views)
Chem Commun (ISSN: 1359-7345, 1364-548x, 1364-548xelectronic), 2012; 48(70): 8838-8840.
Impact Factor: 6.378
View Export to BibTeX Export to EndNote
Tornesello AL, Aurilio M, Accardo A, Tarallo L, Barbieri A, Arra C, Tesauro D, Morelli G, Aloj L
* Gastrin and cholecystokinin peptide-based radiopharmaceuticals: An in vivo and in vitro comparison (380 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2011 May; 17(5): 405-412.
Impact Factor: 1.799
View Export to BibTeX Export to EndNote
Corona C, Frazzini V, Silvestri E, Lattanzio R, La Sorda R, Piantelli M, Canzoniero LM, Ciavardelli D, Rizzarelli E, Sensi SL
* Effects of dietary supplementation of carnosine on mitochondrial dysfunction, amyloid pathology, and cognitive deficits in 3xTg-AD mice (553 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2011 Mar 15; 6(3): e17971-e17971.
Impact Factor: 4.092
View Export to BibTeX Export to EndNote
Accardo A, Morisco A, Gianolio E, Tesauro D, Mangiapia G, Radulescu A, Brandt A, Morelli G
* Nanoparticles containing octreotide peptides and gadolinium complexes for MRI applications (504 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2011 Feb; 17(2): 154-162.
Impact Factor: 1.799
View Export to BibTeX Export to EndNote
Accardo A, Morisco A, Tesauro D, Pedone C, Morelli G
* Naposomes: A new class of peptide-derivatized, target-selective multimodal nanoparticles for imaging and therapeutic applications (408 views)
Ther Deliv (ISSN: 2041-5990), 2011 Feb; 2(2): 235-257.
Impact Factor: 0
View Export to BibTeX Export to EndNote
Lanza V, Bellia F, D'Agata R, Grasso G, Rizzarelli E, Vecchio G
* New glycoside derivatives of carnosine and analogs resistant to carnosinase hydrolysis: synthesis and characterization of their copper(II) complexes (402 views)
J Chem Res (ISSN: 1873-3344, 0162-0134, 0162-0134print), 2011 Feb; 105(2): 181-188.
Impact Factor: 3.354
View Export to BibTeX Export to EndNote
Digilio G, Menchise V, Gianolio E, Catanzaro V, Carrera C, Napolitano R, Fedeli F, Aime S
* Exofacial protein thiols as a route for the internalization of Gd(III)-based complexes for magnetic resonance imaging cell labeling (455 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2010 Jul 8; 53(13): 4877-4890.
Impact Factor: 5.207
View Export to BibTeX Export to EndNote
Accardo A, Mansi R, Morisco A, Mangiapia G, Paduano L, Tesauro D, Radulescu A, Aurilio M, Aloj L, Arra C, Morelli G
* Peptide modified nanocarriers for selective targeting of bombesin receptors (429 views)
Mol Biosyst (ISSN: 1742-206x), 2010 May; 6(5): 878-887.
Impact Factor: 3.825
View Export to BibTeX Export to EndNote
Arnesano F, Scintilla S, Calò V, Bonfrate E, Ingrosso C, Losacco M, Pellegrino T, Rizzarelli E, Natile G
* Copper-triggered aggregation of ubiquitin (533 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2009 Sep 16; 4(9): e7052-e7052.
Impact Factor: 4.351
View Export to BibTeX Export to EndNote
Accardo A, Tesauro D, Aloj L, Pedone C, Morelli G
* Supramolecular aggregates containing lipophilic Gd(III) complexes as contrast agents in MRI (591 views)
Coord Chem Rev (ISSN: 0010-8545), 2009 Sep; 253(17-18): 2193-2213.
Impact Factor: 11.225
View Export to BibTeX Export to EndNote
Ciaccio C, Tundo GR, Grasso G, Spoto G, Marasco D, Ruvo M, Gioia M, Rizzarelli E, Coletta M
* Somatostatin: a novel substrate and a modulator of insulin-degrading enzyme activity (454 views)
J Mol Biol (ISSN: 1089-8638, 0022-2836, 1089-8638electronic), 2009 Feb 6; 385(5): 1556-1567.
Impact Factor: 3.871
View Export to BibTeX Export to EndNote
Accardo A, Tesauro D, Morelli G, Del Pozzo L, Pedone C, Tornesello AL, Benedetti E
* Supramolecular aggregates derivatized by CCK8 peptide as selective nanocarriers for drug delivery (362 views)
Adv Exp Med Biol (ISSN: 0065-2598, 0065-2598print), 2009; 611: 603-604.
Impact Factor: 2.02
View Export to BibTeX Export to EndNote
Vaccaro M, Mangiapia G, Accardo A, Tesauro D, Gianolio E, Frielinghaus H, Morelli G, Paduano L
* Polymerized mixed aggregates containing gadolinium complex and CCK8 peptide (423 views)
Colloid Polym Sci (ISSN: 0303-402x), 2008 Dec; 286(14-15): 1643-1652.
Impact Factor: 1.736
View Export to BibTeX Export to EndNote
Accardo A, Tesauro D, Del Pozzo L, Mangiapia G, Paduano L, Morelli G
* Micelles by self-assembling peptide-conjugate amphiphile: Synthesis and structural characterization (402 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2008 Sep; 14(8): 903-910.
Impact Factor: 1.654
View Export to BibTeX Export to EndNote
Accardo A, Tesauro D, Aloj L, Tarallo L, Arra C, Mangiapia G, Vaccaro M, Pedone C, Paduano L, Morelli G
* Peptide-containing aggregates as selective nanocarriers for therapeutics (391 views)
Chemmedchem (ISSN: 1860-7179, 1860-7187, 1860-7187electronic), 2008 Apr; 3(4): 594-602.
Impact Factor: 3.15
View Export to BibTeX Export to EndNote
D'Andrea LD, Testa I, Panico M, Di Stasi R, Carac C, Tarallo L, Arra C, Barbieri A, Romanelli A, Aloj L
* In vivo and in vitro characterization of CCK8 bearing a histidine-based chelator labeled with Tc-99m-tricarbonyl (424 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2008; 90(5): 707-712.
Impact Factor: 2.823
View Export to BibTeX Export to EndNote
Vaccaro M, Accardo A, D'Errico G, Schillen K, Radulescu A, Tesauro D, Morelli G, Paduano L
* Peptides and gd complexes containing colloidal assemblies as tumor-specific contrast agents in MRI: Physicochemical characterization (399 views)
Biophysical Journal (ISSN: 0006-3495, 1542-0086), 2007 Sep; 93(5): 1736-1746.
Impact Factor: 4.627
View Export to BibTeX Export to EndNote
Cuzzocrea S, Genovese T, Failla M, Vecchio G, Fruciano M, Mazzon E, Di Paola R, Muià C, La Rosa C, Crimi N, Rizzarelli E, Vancheri C
* Protective effect of orally administered carnosine on bleomycin-induced lung injury (575 views)
Am J Physiol Lung Cell Mol Physiol (ISSN: 1040-0605), 2007 May; 292(5): L1095-L1095.
Impact Factor: 4.214
View Export to BibTeX Export to EndNote
Agostini S, Bolzati C, Didonè E, Cavazza-Ceccato M, Refosco F, Aloj L, Arra C, Aurilio M, Tornesello AL, Tesauro D, Morelli G
* The (Tc(N)(PNP))2+ metal fragment labeled cholecystokinin-8 (CCK8) peptide for CCK-2 receptors imaging: In vitro and in vivo studies (400 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2007 Apr; 13(4): 211-219.
Impact Factor: 1.768
View Export to BibTeX Export to EndNote
Accardo A, Tesauro D, Morelli G, Gianolio E, Aime S, Vaccaro M, Mangiapia G, Paduano L, Schillén K
* High-relaxivity supramolecular aggregates containing peptides and Gd complexes as contrast agents in MRI (423 views)
J Biol Inorg Chem (ISSN: 0949-8257, 1432-1327electronic, 0949-8257print), 2007 Feb; 12(2): 267-276.
Impact Factor: 3.325
View Export to BibTeX Export to EndNote
Vaccaro M, Accardo A, Tesauro D, Mangiapia G, Loef D, Schillen K, Soederman O, Morelli G, Paduan L
* Supramolecular aggregates of amphiphilic gadolinium complexes as blood pool MRI/MRA contrast agents: Physicochemical characterization (441 views)
Langmuir (ISSN: 0743-7463), 2006 Jul 18; 22(15): 6635-6643.
Impact Factor: 3.902
View Export to BibTeX Export to EndNote
De Luca S, Sanseverino M, Zocchi I, Pedone C, Morelli G, Ragone R
* Receptor fragment approach to the binding between CCK8 peptide and cholecystokinin receptors: A fluorescence study on type B receptor fragment CCKB-R (352-379) (359 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2005 Mar; 77(4): 205-211.
Impact Factor: 2.545
View Export to BibTeX Export to EndNote
De Luca S, Morelli G
* Synthesis and characterization of a sulfated and a non-sulfated cyclic CCK8 analogue functionalized with a chelating group for metal labelling (395 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2004 May; 10(5): 265-273.
Impact Factor: 1.652
View Export to BibTeX Export to EndNote
Mansi R, Tesauro D, De Capua A, Fattorusso R, Carac C, Aloj L, Benedetti E, Morelli G
* Peptide-chelating agent conjugate for selective targeting of somatostatin receptor type 1: Synthesis and characterization (472 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2004; 76(6): 527-534.
Impact Factor: 2.863
View Export to BibTeX Export to EndNote
Morelli G, De Luca S, Tesauro D, Saviano M, Pedone C, Dolmella A, Visentin R, Mazzi U
* CCK8 peptide derivatized with diphenylphosphine for rhenium labelling: Synthesis and molecular mechanics calculations (323 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2002 Jul; 8(7): 373-381.
Impact Factor: 1.691
View Export to BibTeX Export to EndNote
Aloj L, Zannetti A, Caraco C, Del Vecchio S, Tasauro D, De Luca S, Brunetti A, Aime S, Morelli G, Pedone C
* Characterization of 111In labeled CCK8 peptide coupled to a novel DTPA-like derivative in CCK-B receptor overexpressing cells (402 views)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 2001 Sep; 28(8): N/D-N/D.
Impact Factor: 3.464
View Export to BibTeX Export to EndNote
* Repurposing of Copper(II)-chelating Drugs for the Treatment of Neurodegenerative Diseases (708 views)
Curr Med Chem (ISSN: 1875-533xelectronic, 0929-8673linking), 2018 Feb 12; 25(4): 525-539.
Impact Factor: 3.249
View Export to BibTeX Export to EndNote
Barresi V, Spampinato G, Musso N, Trovato Salinaro A, Rizzarelli E, Condorelli DF
* ATOX1 gene silencing increases susceptibility to anticancer therapy based on copper ionophores or chelating drugs (719 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2016; 156: 145-152.
Impact Factor: 3.348
View Export to BibTeX Export to EndNote
Nardon C, Boscutti G, Dalla Via L, Ringhieri P, Di Noto V, Morelli G, Accardo A, Fregona D
* CCK8 peptide-labeled Pluronic® F127 micelles as a targeted vehicle of gold-based anticancer chemotherapeutics (408 views)
Medchemcomm (ISSN: 2040-2503), 2015; 6(1): 155-163.
Impact Factor: 2.319
View Export to BibTeX Export to EndNote
Accardo A, Ringhieri P, Szekely N, Pipich V, Luchini A, Paduano L, Tesauro D
* Structural insights on nanoparticles containing gadolinium complexes as potential theranostic (454 views)
Colloid Polym Sci (ISSN: 0303-402x), 2014 May; 292(5): 1121-1127.
Impact Factor: 1.865
View Export to BibTeX Export to EndNote
Grasso GI, Arena G, Bellia F, Rizzarelli E, Vecchio G
* Copper(II)-chelating homocarnosine glycoconjugate as a new multifunctional compound (560 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2014 Feb; 131: 56-63.
Impact Factor: 3.444
View Export to BibTeX Export to EndNote
Calce E, Monfregola L, De Luca S
* Synthetic Strategy to Prepare DOTA-Based Bifunctional Chelating Agent Ready to Bind Biomolecular Probes (460 views)
Int J Pept Res Ther (ISSN: 1573-3149, 0929-5666), 2013 Sep; 19(3): 199-202.
Impact Factor: 0.825
View Export to BibTeX Export to EndNote
Accardo A, Gianolio E, Arena F, Barnert S, Schubert R, Tesauro D, Morelli G
* Nanostructures based on monoolein or diolein and amphiphilic gadolinium complexes as MRI contrast agents (412 views)
J Mater Chem B (ISSN: 2050-7518, 2050-750x), 2013; 1(5): 617-628.
Impact Factor: 8.535
View Export to BibTeX Export to EndNote
Di Fiore A, Maresca A, Supuran CT, De Simone G
* Hydroxamate represents a versatile zinc binding group for the development of new carbonic anhydrase inhibitors (361 views)
Chem Commun (ISSN: 1359-7345, 1364-548x, 1364-548xelectronic), 2012; 48(70): 8838-8840.
Impact Factor: 6.378
View Export to BibTeX Export to EndNote
Tornesello AL, Aurilio M, Accardo A, Tarallo L, Barbieri A, Arra C, Tesauro D, Morelli G, Aloj L
* Gastrin and cholecystokinin peptide-based radiopharmaceuticals: An in vivo and in vitro comparison (380 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2011 May; 17(5): 405-412.
Impact Factor: 1.799
View Export to BibTeX Export to EndNote
Corona C, Frazzini V, Silvestri E, Lattanzio R, La Sorda R, Piantelli M, Canzoniero LM, Ciavardelli D, Rizzarelli E, Sensi SL
* Effects of dietary supplementation of carnosine on mitochondrial dysfunction, amyloid pathology, and cognitive deficits in 3xTg-AD mice (553 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2011 Mar 15; 6(3): e17971-e17971.
Impact Factor: 4.092
View Export to BibTeX Export to EndNote
Accardo A, Morisco A, Gianolio E, Tesauro D, Mangiapia G, Radulescu A, Brandt A, Morelli G
* Nanoparticles containing octreotide peptides and gadolinium complexes for MRI applications (504 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2011 Feb; 17(2): 154-162.
Impact Factor: 1.799
View Export to BibTeX Export to EndNote
Accardo A, Morisco A, Tesauro D, Pedone C, Morelli G
* Naposomes: A new class of peptide-derivatized, target-selective multimodal nanoparticles for imaging and therapeutic applications (408 views)
Ther Deliv (ISSN: 2041-5990), 2011 Feb; 2(2): 235-257.
Impact Factor: 0
View Export to BibTeX Export to EndNote
Lanza V, Bellia F, D'Agata R, Grasso G, Rizzarelli E, Vecchio G
* New glycoside derivatives of carnosine and analogs resistant to carnosinase hydrolysis: synthesis and characterization of their copper(II) complexes (402 views)
J Chem Res (ISSN: 1873-3344, 0162-0134, 0162-0134print), 2011 Feb; 105(2): 181-188.
Impact Factor: 3.354
View Export to BibTeX Export to EndNote
Digilio G, Menchise V, Gianolio E, Catanzaro V, Carrera C, Napolitano R, Fedeli F, Aime S
* Exofacial protein thiols as a route for the internalization of Gd(III)-based complexes for magnetic resonance imaging cell labeling (455 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2010 Jul 8; 53(13): 4877-4890.
Impact Factor: 5.207
View Export to BibTeX Export to EndNote
Accardo A, Mansi R, Morisco A, Mangiapia G, Paduano L, Tesauro D, Radulescu A, Aurilio M, Aloj L, Arra C, Morelli G
* Peptide modified nanocarriers for selective targeting of bombesin receptors (429 views)
Mol Biosyst (ISSN: 1742-206x), 2010 May; 6(5): 878-887.
Impact Factor: 3.825
View Export to BibTeX Export to EndNote
Arnesano F, Scintilla S, Calò V, Bonfrate E, Ingrosso C, Losacco M, Pellegrino T, Rizzarelli E, Natile G
* Copper-triggered aggregation of ubiquitin (533 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2009 Sep 16; 4(9): e7052-e7052.
Impact Factor: 4.351
View Export to BibTeX Export to EndNote
Accardo A, Tesauro D, Aloj L, Pedone C, Morelli G
* Supramolecular aggregates containing lipophilic Gd(III) complexes as contrast agents in MRI (591 views)
Coord Chem Rev (ISSN: 0010-8545), 2009 Sep; 253(17-18): 2193-2213.
Impact Factor: 11.225
View Export to BibTeX Export to EndNote
Ciaccio C, Tundo GR, Grasso G, Spoto G, Marasco D, Ruvo M, Gioia M, Rizzarelli E, Coletta M
* Somatostatin: a novel substrate and a modulator of insulin-degrading enzyme activity (454 views)
J Mol Biol (ISSN: 1089-8638, 0022-2836, 1089-8638electronic), 2009 Feb 6; 385(5): 1556-1567.
Impact Factor: 3.871
View Export to BibTeX Export to EndNote
Accardo A, Tesauro D, Morelli G, Del Pozzo L, Pedone C, Tornesello AL, Benedetti E
* Supramolecular aggregates derivatized by CCK8 peptide as selective nanocarriers for drug delivery (362 views)
Adv Exp Med Biol (ISSN: 0065-2598, 0065-2598print), 2009; 611: 603-604.
Impact Factor: 2.02
View Export to BibTeX Export to EndNote
Vaccaro M, Mangiapia G, Accardo A, Tesauro D, Gianolio E, Frielinghaus H, Morelli G, Paduano L
* Polymerized mixed aggregates containing gadolinium complex and CCK8 peptide (423 views)
Colloid Polym Sci (ISSN: 0303-402x), 2008 Dec; 286(14-15): 1643-1652.
Impact Factor: 1.736
View Export to BibTeX Export to EndNote
Accardo A, Tesauro D, Del Pozzo L, Mangiapia G, Paduano L, Morelli G
* Micelles by self-assembling peptide-conjugate amphiphile: Synthesis and structural characterization (402 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2008 Sep; 14(8): 903-910.
Impact Factor: 1.654
View Export to BibTeX Export to EndNote
Accardo A, Tesauro D, Aloj L, Tarallo L, Arra C, Mangiapia G, Vaccaro M, Pedone C, Paduano L, Morelli G
* Peptide-containing aggregates as selective nanocarriers for therapeutics (391 views)
Chemmedchem (ISSN: 1860-7179, 1860-7187, 1860-7187electronic), 2008 Apr; 3(4): 594-602.
Impact Factor: 3.15
View Export to BibTeX Export to EndNote
D'Andrea LD, Testa I, Panico M, Di Stasi R, Carac C, Tarallo L, Arra C, Barbieri A, Romanelli A, Aloj L
* In vivo and in vitro characterization of CCK8 bearing a histidine-based chelator labeled with Tc-99m-tricarbonyl (424 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2008; 90(5): 707-712.
Impact Factor: 2.823
View Export to BibTeX Export to EndNote
Vaccaro M, Accardo A, D'Errico G, Schillen K, Radulescu A, Tesauro D, Morelli G, Paduano L
* Peptides and gd complexes containing colloidal assemblies as tumor-specific contrast agents in MRI: Physicochemical characterization (399 views)
Biophysical Journal (ISSN: 0006-3495, 1542-0086), 2007 Sep; 93(5): 1736-1746.
Impact Factor: 4.627
View Export to BibTeX Export to EndNote
Cuzzocrea S, Genovese T, Failla M, Vecchio G, Fruciano M, Mazzon E, Di Paola R, Muià C, La Rosa C, Crimi N, Rizzarelli E, Vancheri C
* Protective effect of orally administered carnosine on bleomycin-induced lung injury (575 views)
Am J Physiol Lung Cell Mol Physiol (ISSN: 1040-0605), 2007 May; 292(5): L1095-L1095.
Impact Factor: 4.214
View Export to BibTeX Export to EndNote
Agostini S, Bolzati C, Didonè E, Cavazza-Ceccato M, Refosco F, Aloj L, Arra C, Aurilio M, Tornesello AL, Tesauro D, Morelli G
* The (Tc(N)(PNP))2+ metal fragment labeled cholecystokinin-8 (CCK8) peptide for CCK-2 receptors imaging: In vitro and in vivo studies (400 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2007 Apr; 13(4): 211-219.
Impact Factor: 1.768
View Export to BibTeX Export to EndNote
Accardo A, Tesauro D, Morelli G, Gianolio E, Aime S, Vaccaro M, Mangiapia G, Paduano L, Schillén K
* High-relaxivity supramolecular aggregates containing peptides and Gd complexes as contrast agents in MRI (423 views)
J Biol Inorg Chem (ISSN: 0949-8257, 1432-1327electronic, 0949-8257print), 2007 Feb; 12(2): 267-276.
Impact Factor: 3.325
View Export to BibTeX Export to EndNote
Vaccaro M, Accardo A, Tesauro D, Mangiapia G, Loef D, Schillen K, Soederman O, Morelli G, Paduan L
* Supramolecular aggregates of amphiphilic gadolinium complexes as blood pool MRI/MRA contrast agents: Physicochemical characterization (441 views)
Langmuir (ISSN: 0743-7463), 2006 Jul 18; 22(15): 6635-6643.
Impact Factor: 3.902
View Export to BibTeX Export to EndNote
De Luca S, Sanseverino M, Zocchi I, Pedone C, Morelli G, Ragone R
* Receptor fragment approach to the binding between CCK8 peptide and cholecystokinin receptors: A fluorescence study on type B receptor fragment CCKB-R (352-379) (359 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2005 Mar; 77(4): 205-211.
Impact Factor: 2.545
View Export to BibTeX Export to EndNote
De Luca S, Morelli G
* Synthesis and characterization of a sulfated and a non-sulfated cyclic CCK8 analogue functionalized with a chelating group for metal labelling (395 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2004 May; 10(5): 265-273.
Impact Factor: 1.652
View Export to BibTeX Export to EndNote
Mansi R, Tesauro D, De Capua A, Fattorusso R, Carac C, Aloj L, Benedetti E, Morelli G
* Peptide-chelating agent conjugate for selective targeting of somatostatin receptor type 1: Synthesis and characterization (472 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2004; 76(6): 527-534.
Impact Factor: 2.863
View Export to BibTeX Export to EndNote
Morelli G, De Luca S, Tesauro D, Saviano M, Pedone C, Dolmella A, Visentin R, Mazzi U
* CCK8 peptide derivatized with diphenylphosphine for rhenium labelling: Synthesis and molecular mechanics calculations (323 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2002 Jul; 8(7): 373-381.
Impact Factor: 1.691
View Export to BibTeX Export to EndNote
Aloj L, Zannetti A, Caraco C, Del Vecchio S, Tasauro D, De Luca S, Brunetti A, Aime S, Morelli G, Pedone C
* Characterization of 111In labeled CCK8 peptide coupled to a novel DTPA-like derivative in CCK-B receptor overexpressing cells (402 views)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 2001 Sep; 28(8): N/D-N/D.
Impact Factor: 3.464
View Export to BibTeX Export to EndNote
33 Records (29 excluding Abstracts).
Total impact factor: 110.92 (94.799 excluding Abstracts).
Total 5 year impact factor: 115.044 (97.138 excluding Abstracts).
Total impact factor: 110.92 (94.799 excluding Abstracts).
Total 5 year impact factor: 115.044 (97.138 excluding Abstracts).
398 views. Last view on Wednesday 15 March 2023, 14:46:19
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