Ribosome's mode of function: Myths, facts and recent results (394 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 122-130.
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Keywords: Antibiotics, Nanomachine, Peptide Biosynthesis, Ribosome, Tunnel, X-Ray Crystallography, Peptidyltransferase, Ribosome Protein, Catalysis, Chemical Bond, Conference Paper, Polymerization, Priority Journal, Protein Expression, Protein Synthesis, Rna Translation, Animal, Binding Site, Chemical Structure, Chemistry, Human, Metabolism, Protein Conformation, Review, Models, Molecular, Ribosomal Proteins,
Affiliations:
*** IBB - CNR ***
Weizmann Inst. of Science, Rehovot 76100, Israel
Istituto di Biostrutture e Bioimmagini, C.N.R., I-80134 Napoli, Italy
References:
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Bommakanti, A.S., Lindahl, L., Zengel, J.M., Mutation from guanine to adenine in 25s RRNA at the position equivalent to e. Coli a2058 does not confer erythromycin sensitivity in sacchromyces cerevisae (2008) RNA, 14, pp. 460-464
Johansson, M., Bouakaz, E., Lovmar, M., Ehrenberg, M., The kinetics of ribosomal peptidyl transfer revisited (2008) Mol. Cells, 30, pp. 589-598
Youngman, E. M., McDonald, M. E., Green, R., Peptide release on the ribosome: Mechanism and implications for translational control (2008) Annu. Rev. Microbiol, 62, pp. 353-363
Agrawal, R. K., Heagle, A. B., Penczek, P., Grassucci, R. A., Frank, J., Ef-g-dependent gtp hydrolysis induces translocation accompanied by large conformational changes in the 70s ribosome (1999) Nat Struct Biol, 6, pp. 643-647
Palade, G. E., A small particulate component of the cytoplasm (1955) J. Biophys. Biochem. Cytol, 1, pp. 59-68
Noller, H. F., Structure of ribosomal RNA (1984) Annu. Rev. Biochem, 53, pp. 119-162
Noller, H. F., Hoffarth, V., Zimniak, L., Unusual resistance of peptidyl transferase to protein extraction procedures (1992) Science, 256, pp. 1416-1419
Yusupov, M. M., Yusupova, G. Z., Baucom, A., Lieberman, K., Earnest, T. N., Cate, J. H., Noller, H. F., Crystal structure of the ribosome at 5. 5 a resolution (2001) Science, 292, pp. 883-896
Bayfield, M. A., Dahlberg, A. E., Schulmeister, U., Dorner, S., Barta, A., A conformational change in the ribosomal peptidyl transferase center upon active/inactive transition (2001) Proc. Natl. Acad Sci. U. S. A, 98, pp. 10096-10101
Weinger, J. S., Strobel, S. A., Exploring the mechanism of protein synthesis with modified substrates and novel intermediate mimics (2007) Blood Cells Mol. Dis, 38, pp. 110-116
Sato, N. S., Hirabayashi, N., Agmon, I., Yonath, A., Suzuki, T., Comprehensive genetic selection revealed essential bases in the peptidyl-transferase center (2006) Proc Natl. Acad. Sci. U. S. A, 103, pp. 15386-15391
Weinger, J. S., Parnell, K. M., Dorner, S., Green, R., Strobel, S. A., Substrate-assisted catalysis of peptide bond formation by the ribosome (2004) Nat. Struct. Mol. Biol, 11, pp. 1101-1106
Youngman, E. M., Brunelle, J. L., Kochaniak, A. B., Green, R., The active site of the ribosome is composed of two layers of conserved nucleotides with distinct roles in peptide bond formation and peptide release (2004) Cell, 117, pp. 589-599
Lodmell, J. S., Dahlberg, A. E., A conformational switch in escherichia coli 16s ribosomal RNA during decoding of messenger RNA (1997) Science, 277, pp. 1262-1267
Maguire, B. A., Beniaminov, A. D., Ramu, H., Mankin, A. S., Zimmermann, R. A., A protein component at the heart of an RNA machine: The importance of protein 127 for the function of the bacterial ribosome (2005) Mol. Cells, 20, pp. 427-435
Cooperman, B. S., Wooten, T., Romero, D. P., Traut, R. R., Histidine 229 in protein I2 is apparently essential for 50s peptidyl transferase activity (1995) Biochem. Cell Biol, 73, pp. 1087-1094
Malkin, L. I., Rich, A., Partial resistance of nascent polypepticle chains to proteolytic digestion due to ribosomal shielding (1967) J. Mol. Biol, 26, pp. 329-346
Sabatini, D. D., Blobel, G., Controlled proteolysis of nascent polypepticles in rat I iver cell fractions. Ii. Location of the polypeptides in rough microsomes (1970) J. Cell Biol, 45, pp. 146-157
Milligan, R. A., Unwin, P. N., Location of exit channel for nascent protein in 80s ribosome (1986) Nature, 319, pp. 693-695
Crowley, K. S., Reinhart, G. D., Johnson, A. E., The signal sequence moves through a ribosomal tunnel into a noncytoplasmic aqueous environment at the er membrane early in translocation (1993) Cell, 73, pp. 1101-1115
Gabashvili, I. S., Gregory, S. T., Valle, M., Grassucci, R., Worbs, M., Wahl, M. C., Dahiberg, A. E., Frank, J., The polypeptide tunnel system in ihe ribosome and its gating in erythromycin resistance mutants of 14 and 122 (2001) Mol. Cells, 8, pp. 181-188
Woolhead, C. A., McCormick, P. J., Johnson, A. E., Nascent membrane and secretory proteins differ in fret-detected folding far inside the ribosome and in their exposure to ribosomal proteins (2004) Cell, 116, pp. 725-736
Johnson, A. E., Functional ramifications of fret-detected nascent chain folding far inside the membrane-bound ribosome (2004) Biochem. Soc. Trans, 32, pp. 668-672
Deane, C. M., Dong, M., Huard, F. P., Lance, B. K., Wood, G. R., Cotranslational protein folding-fact or fiction? (2007) Bioinformatics, 23, pp. i142-i148
Kaiser, C. M., Chang, H. C., Agashe, V. R., Lakshmipathy, S. K., Etchells, S. A., Hayer-Hartl, M., Hartl, F. U., Barral, J. M., Real-time observation of trigger factor function on translating ribosomes (2006) Nature, 444, pp. 455-460
Hansen, J. L., Moore, P. B., Steitz, T. A., Structures of five antibiotics bound at the peptidyl transferase center of the large ribosomal subunit (2003) J. Mol. Biol, 330, pp. 1061-1075
Ippolito, J. A., Kanyo, Z. F., Wang, D., Franceschi, F. J., Moore, P. B., Stejtz, T. A., Duffy, E. M., Crystal structure of the oxazolidinone antibiotic linezolid bound to the 50s ribosomal subunit (2008) J. Med. Chem, 51 (12), pp. 3353-3356
Hansen, J. L., Ippolito, J. A., Ban, N., Nissen, P., Moore, P. B., Steitz, T. A., The structures of four macrolide antibiotics bound to the large ribosomal subunit (2002) Mol. Cells, 10, pp. 117-128
Gregory, S. T., Dahlberg, A. E., Erythromycin resistance mutations in ribosomal proteins 122 and 14 perturb the higher order structure of 23 s ribosomal RNA (1999) J. Mol. Biol, 289, pp. 827-834
Bottger, E. C., Antimicrobial agents targeting the ribosome: The issue of selectivity and toxicity - lessons to be learned (2007) Cell. Mol. Life Sci, 64, pp. 791-795
Bommakanti, A. S., Lindahl, L., Zengel, J. M., Mutation from guanine to adenine in 25s RRNA at the position equivalent to e. Coli a2058 does not confer erythromycin sensitivity in sacchromyces cerevisae (2008) RNA, 14, pp. 460-464
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 122-130.
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Keywords: Antibiotics, Nanomachine, Peptide Biosynthesis, Ribosome, Tunnel, X-Ray Crystallography, Peptidyltransferase, Ribosome Protein, Catalysis, Chemical Bond, Conference Paper, Polymerization, Priority Journal, Protein Expression, Protein Synthesis, Rna Translation, Animal, Binding Site, Chemical Structure, Chemistry, Human, Metabolism, Protein Conformation, Review, Models, Molecular, Ribosomal Proteins,
Affiliations:
*** IBB - CNR ***
Weizmann Inst. of Science, Rehovot 76100, Israel
Istituto di Biostrutture e Bioimmagini, C.N.R., I-80134 Napoli, Italy
References:
Bashan, A., Yonath, A., Correlating ribosome function with high-resolution structures (2008) Trends. Microbiol, 9, pp. 326-33
Youngman, E.M., McDonald, M.E., Green, R., Peptide release on the ribosome: Mechanism and implications for translational control (2008) Annu. Rev. Microbiol, 62, pp. 353-363
Yonath, A., Muessig, J., Tesche, B., Lorenz, S., Erdmann, V.A., Wittmann, H.G., Crystallization of the large ribosomal subunit from b. Stearothermophilus (1980) Biochem. Int, 1, pp. 315-428
Auerbach-Nevo, T., Zarivach, R., Peretz, M., Yonath, A., Reproducible growth of well diffracting ribosomal crystals (2005) Acta Crystollogr. D Biol. Crystallogr, 61, pp. 713-719
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Weinger, J. S., Strobel, S. A., Exploring the mechanism of protein synthesis with modified substrates and novel intermediate mimics (2007) Blood Cells Mol. Dis, 38, pp. 110-116
Sato, N. S., Hirabayashi, N., Agmon, I., Yonath, A., Suzuki, T., Comprehensive genetic selection revealed essential bases in the peptidyl-transferase center (2006) Proc Natl. Acad. Sci. U. S. A, 103, pp. 15386-15391
Weinger, J. S., Parnell, K. M., Dorner, S., Green, R., Strobel, S. A., Substrate-assisted catalysis of peptide bond formation by the ribosome (2004) Nat. Struct. Mol. Biol, 11, pp. 1101-1106
Youngman, E. M., Brunelle, J. L., Kochaniak, A. B., Green, R., The active site of the ribosome is composed of two layers of conserved nucleotides with distinct roles in peptide bond formation and peptide release (2004) Cell, 117, pp. 589-599
Lodmell, J. S., Dahlberg, A. E., A conformational switch in escherichia coli 16s ribosomal RNA during decoding of messenger RNA (1997) Science, 277, pp. 1262-1267
Maguire, B. A., Beniaminov, A. D., Ramu, H., Mankin, A. S., Zimmermann, R. A., A protein component at the heart of an RNA machine: The importance of protein 127 for the function of the bacterial ribosome (2005) Mol. Cells, 20, pp. 427-435
Cooperman, B. S., Wooten, T., Romero, D. P., Traut, R. R., Histidine 229 in protein I2 is apparently essential for 50s peptidyl transferase activity (1995) Biochem. Cell Biol, 73, pp. 1087-1094
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Sabatini, D. D., Blobel, G., Controlled proteolysis of nascent polypepticles in rat I iver cell fractions. Ii. Location of the polypeptides in rough microsomes (1970) J. Cell Biol, 45, pp. 146-157
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Gabashvili, I. S., Gregory, S. T., Valle, M., Grassucci, R., Worbs, M., Wahl, M. C., Dahiberg, A. E., Frank, J., The polypeptide tunnel system in ihe ribosome and its gating in erythromycin resistance mutants of 14 and 122 (2001) Mol. Cells, 8, pp. 181-188
Woolhead, C. A., McCormick, P. J., Johnson, A. E., Nascent membrane and secretory proteins differ in fret-detected folding far inside the ribosome and in their exposure to ribosomal proteins (2004) Cell, 116, pp. 725-736
Johnson, A. E., Functional ramifications of fret-detected nascent chain folding far inside the membrane-bound ribosome (2004) Biochem. Soc. Trans, 32, pp. 668-672
Deane, C. M., Dong, M., Huard, F. P., Lance, B. K., Wood, G. R., Cotranslational protein folding-fact or fiction? (2007) Bioinformatics, 23, pp. i142-i148
Kaiser, C. M., Chang, H. C., Agashe, V. R., Lakshmipathy, S. K., Etchells, S. A., Hayer-Hartl, M., Hartl, F. U., Barral, J. M., Real-time observation of trigger factor function on translating ribosomes (2006) Nature, 444, pp. 455-460
Hansen, J. L., Moore, P. B., Steitz, T. A., Structures of five antibiotics bound at the peptidyl transferase center of the large ribosomal subunit (2003) J. Mol. Biol, 330, pp. 1061-1075
Ippolito, J. A., Kanyo, Z. F., Wang, D., Franceschi, F. J., Moore, P. B., Stejtz, T. A., Duffy, E. M., Crystal structure of the oxazolidinone antibiotic linezolid bound to the 50s ribosomal subunit (2008) J. Med. Chem, 51 (12), pp. 3353-3356
Hansen, J. L., Ippolito, J. A., Ban, N., Nissen, P., Moore, P. B., Steitz, T. A., The structures of four macrolide antibiotics bound to the large ribosomal subunit (2002) Mol. Cells, 10, pp. 117-128
Gregory, S. T., Dahlberg, A. E., Erythromycin resistance mutations in ribosomal proteins 122 and 14 perturb the higher order structure of 23 s ribosomal RNA (1999) J. Mol. Biol, 289, pp. 827-834
Bottger, E. C., Antimicrobial agents targeting the ribosome: The issue of selectivity and toxicity - lessons to be learned (2007) Cell. Mol. Life Sci, 64, pp. 791-795
Bommakanti, A. S., Lindahl, L., Zengel, J. M., Mutation from guanine to adenine in 25s RRNA at the position equivalent to e. Coli a2058 does not confer erythromycin sensitivity in sacchromyces cerevisae (2008) RNA, 14, pp. 460-464
Ribosome's mode of function: Myths, facts and recent results
Ribosomes translate the genetic code into proteins in all living cells with extremely high efficiency, owing to their inherent flexibility and to their spectacular architecture. During the last 6 decades, extensive effort has been made to elucidate the molecular mechanisms associated with their function, and a quantum jump has been made in recent years, once the three dimensional structures of ribosomes and their functional complexes have been determined. These illuminated key issues in ribosome function, confirmed various biochemical, genetic, and medical findings, and revealed mechanistic details beyond previous expectation, thus leading to conceptual revolutions, and turning old myths into actual facts. Copyright © 2008 European Peptide Society and John Wiley & Sons, Ltd.
Ribosomes translate the genetic code into proteins in all living cells with extremely high efficiency, owing to their inherent flexibility and to their spectacular architecture. During the last 6 decades, extensive effort has been made to elucidate the molecular mechanisms associated with their function, and a quantum jump has been made in recent years, once the three dimensional structures of ribosomes and their functional complexes have been determined. These illuminated key issues in ribosome function, confirmed various biochemical, genetic, and medical findings, and revealed mechanistic details beyond previous expectation, thus leading to conceptual revolutions, and turning old myths into actual facts. Copyright © 2008 European Peptide Society and John Wiley & Sons, Ltd.
Ribosome's mode of function: Myths, facts and recent results
Ribosome's mode of function: Myths, facts and recent results
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Alterio V, Esposito D, Monti SM, Supuran CT, De Simone G
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Vullo D, Supuran CT, Scozzafava A, De Simone G, Monti SM, Alterio V, Carta F
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Messori L, Marzo T, Merlino A
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D'Ambrosio K, Lopez M, Dathan NA, Ouahrani-bettache S, Köhler S, Ascione G, Monti SM, Winum JY, De Simone G
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Alterio V, Pan P, Parkkila S, Buonanno M, Supuran CT, Monti SM, De Simone G
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Correale S, Ruggiero A, Capparelli R, Pedone E, Berisio R
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De Simone G, Alterio V, Supuran CT
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Correale S, Ruggiero A, Pedone E, Berisio R
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Impact Factor: 0.568
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De Simone G, Supuran CT
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Impact Factor: 3.197
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Russo Krauss I, Sica F, Mattia CA, Merlino A
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Esposito L, Ruggiero A, Masullo M, Ruocco MR, Lamberti A, Arcari P, Zagari A, Vitagliano L
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Merlino A, Russo Krauss I, Albino A, Pica A, Vergara A, Masullo M, De Vendittis E, Sica F
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Di Fiore A, Monti SM, Innocenti A, Winum J-Y, De Simone G, Supuran CT
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De Simone G, Supuran CT
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Merlino A, Vitagliano L, Howes BD, Verde C, Di Prisco G, Smulevich G, Sica F, Vergara A
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Alterio V, Di Fiore A, D'Ambrosio K, Supuran CT, De Simone G
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Merlino A, Sica F, Mazzarella L, Zagari A, Vergara A
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Alterio V, De Simone G, Monti SM, Scozzafava A, Supuran CT
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Di Fiore A, Scozzafava A, Winum JY, Montero JL, Pedone C, Supuran CT, De Simone G
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Menchise V, De Simone G, Di Fiore A, Scozzafava A, Supuran CT
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Di Fiore A, Pedone C, D'Ambrosio K, Scozzafava A, De Simone G, Supuran CT
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Cimino P, Improta R, Bifulco G, Riccio R, Gomez-paloma L, Barone V
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Bashan A, Agmon I, Zarivach R, Schluenzen F, Harms J, Berisio R, Bartels H, Franceschi F, Auerbach T, Hansen HAS, Kossoy E, Kessler M, Yonath A
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Alterio V, Esposito D, Monti SM, Supuran CT, De Simone G
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Vullo D, Supuran CT, Scozzafava A, De Simone G, Monti SM, Alterio V, Carta F
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Impact Factor: 2.93
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Pica A, Chi M-C, Chen Y-Y, D'Ischia M, Lin L-L, Merlino A
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Impact Factor: 5.476
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Messori L, Marzo T, Merlino A
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Impact Factor: 3.205
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Calvanese L, Falcigno L, Maglione C, Marasco D, Ruggiero A, Squeglia F, Berisio R, D'Auria G
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Impact Factor: 2.385
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D'Ambrosio K, Lopez M, Dathan NA, Ouahrani-bettache S, Köhler S, Ascione G, Monti SM, Winum JY, De Simone G
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Impact Factor: 2.963
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Alterio V, Pan P, Parkkila S, Buonanno M, Supuran CT, Monti SM, De Simone G
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Impact Factor: 2.385
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Ronda L, Merlino A, Bettati S, Verde C, Balsamo A, Mazzarella L, Mozzarelli A, Vergara A
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Impact Factor: 3.191
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Correale S, Ruggiero A, Capparelli R, Pedone E, Berisio R
* Structures of free and inhibited forms of the L, D-transpeptidase LdtMt1 from Mycobacterium tuberculosis (398 views)
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Impact Factor: 7.232
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De Simone G, Alterio V, Supuran CT
* Exploiting the hydrophobic and hydrophilic binding sites for designing carbonic anhydrase inhibitors (507 views)
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Impact Factor: 3.467
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Falciani C, Brunetti J, Lelli B, Accardo A, Tesauro D, Morelli G, Bracci L
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Impact Factor: 1.862
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Accardo A, Mangiapia G, Paduano L, Morelli G, Tesauro D
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Impact Factor: 1.862
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Correale S, Ruggiero A, Pedone E, Berisio R
* Expression, purification, crystallization and preliminary X-ray crystallographic analysis of the l, d-transpeptidase LdtMt1 from Mycobacterium tuberculosis (404 views)
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Impact Factor: 0.568
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De Simone G, Supuran CT
* (In)organic anions as carbonic anhydrase inhibitors (378 views)
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Impact Factor: 3.197
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Russo Krauss I, Sica F, Mattia CA, Merlino A
* Increasing the X-ray diffraction power of protein crystals by dehydration: the case of bovine serum albumin and a survey of literature data (461 views)
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Impact Factor: 2.464
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Esposito L, Ruggiero A, Masullo M, Ruocco MR, Lamberti A, Arcari P, Zagari A, Vitagliano L
* Crystallographic and spectroscopic characterizations of Sulfolobus solfataricus TrxA1 provide insights into the determinants of thioredoxin fold stability (300 views)
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Impact Factor: 3.361
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Merlino A, Russo Krauss I, Albino A, Pica A, Vergara A, Masullo M, De Vendittis E, Sica F
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Impact Factor: 2.598
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Di Fiore A, Monti SM, Innocenti A, Winum J-Y, De Simone G, Supuran CT
* Carbonic anhydrase inhibitors: Crystallographic and solution binding studies for the interaction of a boron-containing aromatic sulfamide with mammalian isoforms I-XV (352 views)
Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x), 2010 Jun 15; 20(12): 3601-3605.
Impact Factor: 2.661
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Berisio R, Ruggiero A, Vitagliano L
* Elongation Factors Efia And Ef-Tu: Their Role In Translation And Beyond (558 views)
Israel Journal Of Chemistry, 2010 Jun; 50(1): 71-79.
Impact Factor: 2.561
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De Simone G, Supuran CT
* Carbonic anhydrase IX: Biochemical and crystallographic characterization of a novel antitumor target (398 views)
Bba-Gen Subjects (ISSN: 1570-9639, 0006-3002, 0925-4439), 2010 Feb; 1804(2): 404-409.
Impact Factor: 2.773
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Guler OO, De Simone G, Supuran CT
* Drug design studies of the novel antitumor targets carbonic anhydrase IX and XII (540 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2010; 17(15): 1516-1526.
Impact Factor: 4.63
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Merlino A, Vitagliano L, Howes BD, Verde C, Di Prisco G, Smulevich G, Sica F, Vergara A
* Combined Crystallographic and Spectroscopic Analysis of Trematomus bernacchii Hemoglobin Highlights Analogies and Differences in the Peculiar Oxidation Pathway of Antarctic Fish Hemoglobins (413 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2009 Dec; 91(12): 1117-1125.
Impact Factor: 2.605
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Ruggiero A, Masullo M, Marasco D, Ruocco MR, Grimaldi P, Arcari P, Zagari A, Vitagliano L
* The dimeric structure of Sulfolobus solfataricus thioredoxin A2 and the basis of its thermostability (316 views)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2009 Dec; 77(4): 1004-1008.
Impact Factor: 3.085
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Alterio V, Di Fiore A, D'Ambrosio K, Supuran CT, De Simone G
* X-Ray Crystallography of Carbonic Anhydrase Inhibitors and Its Importance in Drug Design (426 views)
Drug Des Of Zinc Enzyme Inhibitors (ISSN: 9780-4702, 9780-470275009), 2009; N/D: 73-138.
Impact Factor: 1.156
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Merlino A, Sica F, Mazzarella L, Zagari A, Vergara A
* Correlation between Raman and X-ray crystallography data of (Pro-Pro-Gly)(10) (399 views)
Biophys Chem (ISSN: 0301-4622, 0301-4622linking), 2008 Sep; 137(1): 24-27.
Impact Factor: 2.362
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Alterio V, De Simone G, Monti SM, Scozzafava A, Supuran CT
* Carbonic anhydrase inhibitors: Inhibition of human, bacterial, and archaeal isozymes with benzene-1, 3-disulfonamides-Solution and crystallographic studies (329 views)
Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x), 2007 Sep 1; 17(15): 4201-4207.
Impact Factor: 2.604
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Di Fiore A, Scozzafava A, Winum JY, Montero JL, Pedone C, Supuran CT, De Simone G
* Carbonic anhydrase inhibitors: binding of an antiglaucoma glycosyl-sulfanilamide derivative to human isoform II and its consequences for the drug design of enzyme inhibitors incorporating sugar moieties (410 views)
Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x), 2007 Mar 15; 17(6): 1726-1731.
Impact Factor: 2.604
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Menchise V, De Simone G, Di Fiore A, Scozzafava A, Supuran CT
* Carbonic anhydrase inhibitors: X-ray crystallographic studies for the binding of 5-amino-1, 3, 4-thiadiazole-2-sulfonamide and 5-(4-amino-3-chloro-5-fluorophenylsulfonamido)1, 3, 4-thiadiazole-2-sulfon amide to human isoform II (310 views)
Bioorganic & Medicinal Chemistry Letters (ISSN: 0960-894x), 2006 Dec 15; 16(24): 6204-6208.
Impact Factor: 2.538
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Di Fiore A, Pedone C, D'Ambrosio K, Scozzafava A, De Simone G, Supuran CT
* Carbonic anhydrase inhibitors: Valdecoxib binds to a different active site region of the human isoform II as compared to the structurally related cyclooxygenase II 'selective' inhibitor celecoxib (323 views)
Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x), 2006 Jan 15; 16(2): 437-442.
Impact Factor: 2.538
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Agmon I, Amit M, Auerbach T, Bashan A, Baram D, Bartels H, Berisio R, Greenberg I, Harms J, Hansen HAS, Kessler M, Pyetan E, Schluenzen F, Sittner A, Yonath A, Zarivach R
* Ribosomal crystallography: A flexible nucleotide anchoring tRNA translocation, facilitates peptide-bond formation, chirality discrimination and antibiotics synergism (312 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 2004 Jun 1; 567(1): 20-26.
Impact Factor: 3.843
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Cimino P, Improta R, Bifulco G, Riccio R, Gomez-paloma L, Barone V
* Nucleophilic Cyclopropane Ring Opening in Duocarmycin SA Derivatives by Methanol under Acid Conditions: A Quantum Mechanical Study in the Gas-Phase and in Solution (445 views)
J Org Chem (ISSN: 0022-3263, 0022-3263linking), 2004; 69(8): 2816-2824.
Impact Factor: 3.462
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Isernia C, Bucci E, Leone M, Zaccaro L, Di Lello P, Digilio G, Esposito S, Saviano M, Di Blasio B, Pedone C, Pedone PV, Fattorusso R
* NMR structure of the single QALGGH zinc finger domain from the Arabidopsis thaliana SUPERMAN protein (429 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2003 Mar 3; 4(2-3): 171-180.
Impact Factor: 3.992
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Bashan A, Agmon I, Zarivach R, Schluenzen F, Harms J, Berisio R, Bartels H, Franceschi F, Auerbach T, Hansen HAS, Kossoy E, Kessler M, Yonath A
* Structural basis of the ribosomal machinery for peptide bond formation, translocation, and nascent chain progression (453 views)
Mol Cell (ISSN: 1097-2765, 1097-4164), 2003 Jan; 11(1): 91-102.
Impact Factor: 16.835
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Yonath A, Bashan A, Zarivach R, Franceschi F, Schluenzen F, Harms J, Albrecht R, Berisio R
* Methods Of Growing Crystals Of Free, Antibiotic-Complexed, And Substrate-Complexed Large Ribosomal Subunits, And Methods Of Rational Designing Or Identifying Antibiotics Using Structure Coordinate Data Derived From Such Crystals (292 views)
International Publication Number, 2003; N/D: N/D-N/D.
Impact Factor: 4.622
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Esposito L, Sica F, Raia CA, Giordano A, Rossi M, Mazzarella L, Zagari A
* Crystal Structure Of The Alcohol Dehydrogenase From The Hyperthermophilic Archaeon Sulfolobus Solfataricus At 1. 85 Angstrom Resolution (435 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2002 Apr 26; 318(2): 463-477.
Impact Factor: 5.359
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Romanelli A, Garella I, Menchise V, Iacovino R, Saviano M, Montesarchio D, Didierjean C, Lello PD, Rossi F, Benedetti E
* Crystal-state conformation of Cα, α-dialkylated peptides containing chiral β-homo-residues (512 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2001; 7(1): 15-26.
Impact Factor: 1.451
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Ciarmiello A, Del Vecchio S, Silvestro P, Potena MI, Carriero MV, Thomas R, Botti G, D'Aiuto G, Salvatore M
Tumor clearance of technetium 99m-sestamibi as a predictor of response to neoadjuvant chemotherapy for locally advanced breast cancer (468 views)
Journal Of Clinical Oncology (ISSN: 0732-183x), 1998 May; 16(5): 1677-1683.
Impact Factor: 8.228
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46 Records (46 excluding Abstracts).
Total impact factor: 173.927 (173.927 excluding Abstracts).
Total 5 year impact factor: 165.725 (165.725 excluding Abstracts).
Total impact factor: 173.927 (173.927 excluding Abstracts).
Total 5 year impact factor: 165.725 (165.725 excluding Abstracts).
394 views. Last view on Sunday 29 January 2023, 1:36:18
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