Ribosome's mode of function: Myths, facts and recent results(394 views) Wekselman I, Davidovich C, Agmon I, Zimmerman E, Rozenberg H, Bashan A, Berisio R, Yonath A
Keywords: Antibiotics, Nanomachine, Peptide Biosynthesis, Ribosome, Tunnel, X-Ray Crystallography, Peptidyltransferase, Ribosome Protein, Catalysis, Chemical Bond, Conference Paper, Polymerization, Priority Journal, Protein Expression, Protein Synthesis, Rna Translation, Animal, Binding Site, Chemical Structure, Chemistry, Human, Metabolism, Protein Conformation, Review, Models, Molecular, Ribosomal Proteins,
Affiliations: *** IBB - CNR ***
Weizmann Inst. of Science, Rehovot 76100, Israel
Istituto di Biostrutture e Bioimmagini, C.N.R., I-80134 Napoli, Italy
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Weinger, J. S., Strobel, S. A., Exploring the mechanism of protein synthesis with modified substrates and novel intermediate mimics (2007) Blood Cells Mol. Dis, 38, pp. 110-116
Sato, N. S., Hirabayashi, N., Agmon, I., Yonath, A., Suzuki, T., Comprehensive genetic selection revealed essential bases in the peptidyl-transferase center (2006) Proc Natl. Acad. Sci. U. S. A, 103, pp. 15386-15391
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Maguire, B. A., Beniaminov, A. D., Ramu, H., Mankin, A. S., Zimmermann, R. A., A protein component at the heart of an RNA machine: The importance of protein 127 for the function of the bacterial ribosome (2005) Mol. Cells, 20, pp. 427-435
Cooperman, B. S., Wooten, T., Romero, D. P., Traut, R. R., Histidine 229 in protein I2 is apparently essential for 50s peptidyl transferase activity (1995) Biochem. Cell Biol, 73, pp. 1087-1094
Malkin, L. I., Rich, A., Partial resistance of nascent polypepticle chains to proteolytic digestion due to ribosomal shielding (1967) J. Mol. Biol, 26, pp. 329-346
Sabatini, D. D., Blobel, G., Controlled proteolysis of nascent polypepticles in rat I iver cell fractions. Ii. Location of the polypeptides in rough microsomes (1970) J. Cell Biol, 45, pp. 146-157
Milligan, R. A., Unwin, P. N., Location of exit channel for nascent protein in 80s ribosome (1986) Nature, 319, pp. 693-695
Crowley, K. S., Reinhart, G. D., Johnson, A. E., The signal sequence moves through a ribosomal tunnel into a noncytoplasmic aqueous environment at the er membrane early in translocation (1993) Cell, 73, pp. 1101-1115
Gabashvili, I. S., Gregory, S. T., Valle, M., Grassucci, R., Worbs, M., Wahl, M. C., Dahiberg, A. E., Frank, J., The polypeptide tunnel system in ihe ribosome and its gating in erythromycin resistance mutants of 14 and 122 (2001) Mol. Cells, 8, pp. 181-188
Woolhead, C. A., McCormick, P. J., Johnson, A. E., Nascent membrane and secretory proteins differ in fret-detected folding far inside the ribosome and in their exposure to ribosomal proteins (2004) Cell, 116, pp. 725-736
Johnson, A. E., Functional ramifications of fret-detected nascent chain folding far inside the membrane-bound ribosome (2004) Biochem. Soc. Trans, 32, pp. 668-672
Deane, C. M., Dong, M., Huard, F. P., Lance, B. K., Wood, G. R., Cotranslational protein folding-fact or fiction? (2007) Bioinformatics, 23, pp. i142-i148
Kaiser, C. M., Chang, H. C., Agashe, V. R., Lakshmipathy, S. K., Etchells, S. A., Hayer-Hartl, M., Hartl, F. U., Barral, J. M., Real-time observation of trigger factor function on translating ribosomes (2006) Nature, 444, pp. 455-460
Hansen, J. L., Moore, P. B., Steitz, T. A., Structures of five antibiotics bound at the peptidyl transferase center of the large ribosomal subunit (2003) J. Mol. Biol, 330, pp. 1061-1075
Ippolito, J. A., Kanyo, Z. F., Wang, D., Franceschi, F. J., Moore, P. B., Stejtz, T. A., Duffy, E. M., Crystal structure of the oxazolidinone antibiotic linezolid bound to the 50s ribosomal subunit (2008) J. Med. Chem, 51 (12), pp. 3353-3356
Hansen, J. L., Ippolito, J. A., Ban, N., Nissen, P., Moore, P. B., Steitz, T. A., The structures of four macrolide antibiotics bound to the large ribosomal subunit (2002) Mol. Cells, 10, pp. 117-128
Gregory, S. T., Dahlberg, A. E., Erythromycin resistance mutations in ribosomal proteins 122 and 14 perturb the higher order structure of 23 s ribosomal RNA (1999) J. Mol. Biol, 289, pp. 827-834
Bottger, E. C., Antimicrobial agents targeting the ribosome: The issue of selectivity and toxicity - lessons to be learned (2007) Cell. Mol. Life Sci, 64, pp. 791-795
Bommakanti, A. S., Lindahl, L., Zengel, J. M., Mutation from guanine to adenine in 25s RRNA at the position equivalent to e. Coli a2058 does not confer erythromycin sensitivity in sacchromyces cerevisae (2008) RNA, 14, pp. 460-464
Ribosome's mode of function: Myths, facts and recent results