Role of FK506-binding protein 51 in the control of apoptosis of irradiated melanoma cells (434 views)
Cell Death Differ (ISSN: 1350-9047, 1476-5403electronic, 1350-9047linking), 2010 Jan; 17(1): 145-157.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 9.05, 5-year impact factor: 8.674
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-77449099093&partnerID=40&md5=c5829bdd6b33313281fb03939fd64643
Keywords: Apoptosis, Autophagy, Fkbp51, Melanoma, Nf-κb, Fk 506 Binding Protein, Immunoglobulin Enhancer Binding Protein, Protein Bax, Small Interfering Rna, Apoptosis Regulatory Protein, Becn1 Protein, Mouse, Tacrolimus Binding Protein 5, X Linked Inhibitor Of Apoptosis, Article, Cancer Cell, Cell Growth, Controlled Study, Degradation, Growth Curve, Human, Human Tissue, Immunohistochemistry, In Vivo Study, Ionizing Radiation, Irradiation, Melanocyte, Melanoma Cell, Neoplasm, Nonhuman, Priority Journal, Protein Function, Radiosensitivity, Skin, Skin Defect, Tumor Xenograft, Animal, Genetics, Metabolism, Nude Mouse, Pathology, Physiology, Tumor Cell Line, Bcl-2-Associated X Protein, Nf-Kappa B, Transplantation, Heterologous, X-Linked Inhibitor Of Apoptosis Protein,
Affiliations:
*** IBB - CNR ***
Department of Biochemistry and Medical Biotechnology, Federico II University of Naples, Via Pansini, 5, 80131, Naples, Italy
Institute of Biostructure and Bio-Imaging, National Research Council (CNR), Naples, Italy
Department of Biomorfological and Functional Sciences, Pathology Section, Federico II University of Naples, Naples, Italy
Division of Biochemistry, Department of Biological and Environmental Sciences, University of Helsinki, Helsinki, Finland
Institute of Endocrinology and Experimental Oncology, Italian National Research Council (CNR), Naples, Italy
Italian National Cancer Institute, G. Pascale Foundation, Naples, Italy
References:
Norris, L.B., Beam, S., Multidisciplinary perspectives on melanoma treatment (2008) Updates from the 44th Annual Meeting of the American Society of Clinical Oncology, the Oncology Nurse, 1, pp. 1-
Dewey, W.C., Ling, C.C., Meyn, R.E., Radiation-induced apoptosis: Relevance to radiotherapy (1995) Int J Radiat Oncol Biol Phys, 33, pp. 781-796
Wallace, S.S., DNA damages processed by base excision repair: Biological consequences (1994) International Journal of Radiation Biology, 66 (5), pp. 579-589
Hengartner, M.O., The biochemistry of apoptosis (2000) Nature, 407, pp. 770-776
Elliott, A., Reiners Jr., J.J., Suppression of autophagy enhances the cytotoxicity of the DNAdamaging aromatic amine p-anilinoaniline (2008) Toxicol Appl Pharmacol, 232, pp. 169-179
Ogata, M., Hino, S.-I., Saito, A., Morikawa, K., Kondo, S., Kanemoto, S., Murakami, T., Imaizumi, K., Autophagy is activated for cell survival after endoplasmic reticulum stress (2006) Molecular and Cellular Biology, 26 (24), pp. 9220-9231. , DOI 10.1128/MCB.01453-06
Eskelinen, E.L., New insights into the mechanisms of macroautophagy in mammalian cells (2008) Int Rev Cell Mol Biol, 266, pp. 207-247. , Review
Baehrecke, E.H., Autophagy: Dual roles in life and death? (2005) Nature Reviews Molecular Cell Biology, 6 (6), pp. 505-510. , DOI 10.1038/nrm1666
Mathew, R., Karantza-Wadsworth, V., White, E., Role of autophagy in cancer (2007) Nature Reviews Cancer, 7 (12), pp. 961-967. , DOI 10.1038/nrc2254, PII NRC2254
Romano, M.F., Avellino, R., Petrella, A., Bisogni, R., Romano, S., Venuta, S., Rapamycin inhibits doxorubicin-induced NF-κB/Rel nuclear activity and enhances the apoptosis of melanoma cells (2004) European Journal of Cancer, 40 (18), pp. 2829-2836. , DOI 10.1016/j.ejca.2004.08.017, PII S095980490400704X
Johnson, G.E., Ivanov, V.N., Hei, T.K., Radiosensitization of melanoma cells through combined inhibition of protein regulators of cell survival (2008) Apoptosis, 13, pp. 790-802
Munshi, A., Kurland, J.F., Nishikawa, T., Chiao, P.J., Andreeff, M., Meyn, R.E., Inhibition of constitutively activated nuclear factor-κB radiosensitizers human cells (2004) Molecular Cancer Therapeutics, 3 (8), pp. 985-992
Ghosh, S., May, M.J., Kopp, E.B., NF-κB and rel proteins: Evolutionarily conserved mediators of immune responses (1998) Annual Review of Immunology, 16, pp. 225-260. , DOI 10.1146/annurev.immunol.16.1.225
Baldwin Jr., A.S., The NF-κB and IκB proteins: New discoveries and insights (1996) Annual Review of Immunology, 14, pp. 649-681
Karin, M., Cao, Y., Greten, F.R., Li, Z.-W., NF-κB in cancer: From innocent bystander to major culprit (2002) Nature Reviews Cancer, 2 (4), pp. 301-310
Baumann, M., Krause, M., Hill, R., Exploring the role of cancer stem cells in radioresistance (2008) Nature Reviews Cancer, 8 (7), pp. 545-554. , DOI 10.1038/nrc2419, PII NRC2419
Romano, S., Mallardo, M., Chiurazzi, F., Bisogni, R., D'Angelillo, A., Liuzzi, R., The effect of FK506 on transforming growth factor beta signaling and apoptosis in chronic lymphocytic leukemia B cells (2008) Haematologica, 93, pp. 75-84
Chen, A.Y., Okunieff, P., Pommier, Y., Mitchell, J.B., Mammalian DNA topoisomerase I mediates the enhancement of radiation cytotoxicity by camptothecin derivatives (1997) Cancer Research, 57 (8), pp. 1529-1536
Kabeya, Y., Mizushima, N., Ueno, T., Yamamoto, A., Kirisako, T., Noda, T., LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing (2000) EMBO J, 19, pp. 5720-5728
Chandler, J.M., Cohen, G.M., MacFarlane, M., Different subcellular distribution of caspase-3 and caspase-7 following Fas-induced apoptosis in mouse liver (1998) Journal of Biological Chemistry, 273 (18), pp. 10815-10818. , DOI 10.1074/jbc.273.18.10815
Habraken, Y., Piette, J., NF-kappaB activation by double-strand breaks (2006) Biochem Pharmacol, 72, pp. 1132-1141. , Review
Copetti, T., Bertoli, C., Dalla, E., Demarchi, F., Schneider, C., P65/RelA modulates BECN1 transcription and autophagy (2009) Mol Cell Biol, 29, pp. 2594-2608
Kim, H., Rafiuddin-Shah, M., Tu, H.-C., Jeffers, J.R., Zambetti, G.P., Hsieh, J.J.-D., Cheng, E.H.-Y., Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies (2006) Nature Cell Biology, 8 (12), pp. 1348-1358. , DOI 10.1038/ncb1499, PII NCB1499
Zhou, S., Schuetz, J.D., Bunting, K.D., Colapietro, A.-M., Sampath, J., Morris, J.J., Lagutina, I., Sorrentino, B.P., The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype (2001) Nature Medicine, 7 (9), pp. 1028-1034. , DOI 10.1038/nm0901-1028
Monzani, E., Facchetti, F., Galmozzi, E., Corsini, E., Benetti, A., Cavazzin, C., Gritti, A., La Porta, C.A.M., Melanoma contains CD133 and ABCG2 positive cells with enhanced tumourigenic potential (2007) European Journal of Cancer, 43 (5), pp. 935-946. , DOI 10.1016/j.ejca.2007.01.017, PII S0959804907000639
Hocker, T.L., Singh, M.K., Tsao, H., Melanoma genetics and therapeutic approaches in the 21st century: Moving from the benchside to the bedside (2008) J Invest Dermatol, 128, pp. 2575-2595
Poeck, H., Besch, R., Maihoefer, C., Renn, M., Tormo, D., Morskaya, S.S., 50-TriphosphatesiRNA: Turning gene silencing and Rig-I activation against melanoma (2008) Nat Med, 14, pp. 1256-1263
Sinars, C.R., Cheung-Flynn, J., Rimerman, R.A., Scammell, J.G., Smith, D.F., Clardy, J., Structure of the large FK506-binding protein FKBP51, an Hsp90-binding protein and a component of steroid receptor complexes (2003) Proceedings of the National Academy of Sciences of the United States of America, 100 (3), pp. 868-873. , DOI 10.1073/pnas.0231020100
Bouwmeester, T., Bauch, A., Ruffner, H., Angrand, P.-O., Bergamini, G., Croughton, K., Cruciat, C., Superti-Furga, G., A physical and functional map of the human TNF-α/NF-κB signal transduction pathway (2004) Nature Cell Biology, 6 (2), pp. 97-105. , DOI 10.1038/ncb1086
Naumann, U., Bahr, O., Wolburg, H., Altenberend, S., Wick, W., Liston, P., Ashkenazi, A., Weller, M., Adenoviral expression of XIAP antisense RNA induces apoptosis in glioma cells and suppresses the growth of xenografts in nude mice (2007) Gene Therapy, 14 (2), pp. 147-161. , DOI 10.1038/sj.gt.3302845, PII 3302845
Zabierowski, S.E., Herlyn, M., Learning the ABCs of Melanoma-Initiating Cells (2008) Cancer Cell, 13 (3), pp. 185-187. , DOI 10.1016/j.ccr.2008.02.015, PII S1535610808000512
Schatton, T., Murphy, G.F., Frank, N.Y., Yamaura, K., Waaga-Gasser, A.M., Gasser, M., Identification of cells initiating human melanomas (2008) Nature, 451, pp. 345-349
Baughman, G., Wiederrecht, G.J., Faith Campbell, N., Martin, M.M., Bourgeois, S., FKBP51, a novel T-cell specific immunophilin capable of calcineurin inhibition (1995) Mol Cell Biol, 15, pp. 4395-4402
Benassi, B., Zupi, G., Biroccio, A., γ-Glutamylcysteine synthetase mediates the c-Myc-dependent response to antineoplastic agents in melanoma cells (2007) Molecular Pharmacology, 72 (4), pp. 1015-1023. , http://molpharm.aspetjournals.org/cgi/reprint/72/4/1015, DOI 10.1124/mol.107.038687
Trotta, P.P., Harrison Jr., S.D., Evaluation of the antitumor activity of recombinant human γ-interferon employing human melanoma xenografts in athymic nude mice (1987) Cancer Research, 47 (20), pp. 5347-5353
Giard, D.J., Aaronson, S.A., Todaro, G.J., Arnstein, P., Kersey, J.H., Dosik, H., In vitro cultivation of human tumors: Establishment of cell lines derived from a series of solid tumors (1973) J Natl Cancer Inst, 51, pp. 1417-1423
Nap, F., Rodermond, H.M., Stap, J., Haveman, J., Van Bree, C., Clonogenic assay of cells in vitro (2006) Nat Protoc, 1, pp. 2315-2319
Staibano, S., Pepe, S., Muzio, L.L., Somma, P., Mascolo, M., Argenziano, G., Scalvenzi, M., De Rosa, G., Poly(adenosine diphosphate-ribose) polymerase 1 expression in malignant melanomas from photoexposed areas of the head and neck region (2005) Human Pathology, 36 (7), pp. 724-731. , DOI 10.1016/j.humpath.2005.04.017, PII S0046817705002315
Norris, L. B., Beam, S., Multidisciplinary perspectives on melanoma treatment (2008) Updates from the 44th Annual Meeting of the American Society of Clinical Oncology, the Oncology Nurse, 1, pp. 1-
Dewey, W. C., Ling, C. C., Meyn, R. E., Radiation-induced apoptosis: Relevance to radiotherapy (1995) Int J Radiat Oncol Biol Phys, 33, pp. 781-796
Wallace, S. S., DNA damages processed by base excision repair: Biological consequences (1994) International Journal of Radiation Biology, 66 (5), pp. 579-589
Hengartner, M. O., The biochemistry of apoptosis (2000) Nature, 407, pp. 770-776
Eskelinen, E. L., New insights into the mechanisms of macroautophagy in mammalian cells (2008) Int Rev Cell Mol Biol, 266, pp. 207-247. , Review
Baehrecke, E. H., Autophagy: Dual roles in life and death? (2005) Nature Reviews Molecular Cell Biology, 6 (6), pp. 505-510. , DOI 10. 1038/nrm1666
Romano, M. F., Avellino, R., Petrella, A., Bisogni, R., Romano, S., Venuta, S., Rapamycin inhibits doxorubicin-induced NF- B/Rel nuclear activity and enhances the apoptosis of melanoma cells (2004) European Journal of Cancer, 40 (18), pp. 2829-2836. , DOI 10. 1016/j. ejca. 2004. 08. 017, PII S095980490400704X
Johnson, G. E., Ivanov, V. N., Hei, T. K., Radiosensitization of melanoma cells through combined inhibition of protein regulators of cell survival (2008) Apoptosis, 13, pp. 790-802
Ghosh, S., May, M. J., Kopp, E. B., NF- B and rel proteins: Evolutionarily conserved mediators of immune responses (1998) Annual Review of Immunology, 16, pp. 225-260. , DOI 10. 1146/annurev. immunol. 16. 1. 225
Baldwin Jr., A. S., The NF- B and I B proteins: New discoveries and insights (1996) Annual Review of Immunology, 14, pp. 649-681
Chen, A. Y., Okunieff, P., Pommier, Y., Mitchell, J. B., Mammalian DNA topoisomerase I mediates the enhancement of radiation cytotoxicity by camptothecin derivatives (1997) Cancer Research, 57 (8), pp. 1529-1536
Chandler, J. M., Cohen, G. M., MacFarlane, M., Different subcellular distribution of caspase-3 and caspase-7 following Fas-induced apoptosis in mouse liver (1998) Journal of Biological Chemistry, 273 (18), pp. 10815-10818. , DOI 10. 1074/jbc. 273. 18. 10815
Hocker, T. L., Singh, M. K., Tsao, H., Melanoma genetics and therapeutic approaches in the 21st century: Moving from the benchside to the bedside (2008) J Invest Dermatol, 128, pp. 2575-2595
Sinars, C. R., Cheung-Flynn, J., Rimerman, R. A., Scammell, J. G., Smith, D. F., Clardy, J., Structure of the large FK506-binding protein FKBP51, an Hsp90-binding protein and a component of steroid receptor complexes (2003) Proceedings of the National Academy of Sciences of the United States of America, 100 (3), pp. 868-873. , DOI 10. 1073/pnas. 0231020100
Zabierowski, S. E., Herlyn, M., Learning the ABCs of Melanoma-Initiating Cells (2008) Cancer Cell, 13 (3), pp. 185-187. , DOI 10. 1016/j. ccr. 2008. 02. 015, PII S1535610808000512
Trotta, P. P., Harrison Jr., S. D., Evaluation of the antitumor activity of recombinant human -interferon employing human melanoma xenografts in athymic nude mice (1987) Cancer Research, 47 (20), pp. 5347-5353
Giard, D. J., Aaronson, S. A., Todaro, G. J., Arnstein, P., Kersey, J. H., Dosik, H., In vitro cultivation of human tumors: Establishment of cell lines derived from a series of solid tumors (1973) J Natl Cancer Inst, 51, pp. 1417-1423
Cell Death Differ (ISSN: 1350-9047, 1476-5403electronic, 1350-9047linking), 2010 Jan; 17(1): 145-157.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 9.05, 5-year impact factor: 8.674
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-77449099093&partnerID=40&md5=c5829bdd6b33313281fb03939fd64643
Keywords: Apoptosis, Autophagy, Fkbp51, Melanoma, Nf-κb, Fk 506 Binding Protein, Immunoglobulin Enhancer Binding Protein, Protein Bax, Small Interfering Rna, Apoptosis Regulatory Protein, Becn1 Protein, Mouse, Tacrolimus Binding Protein 5, X Linked Inhibitor Of Apoptosis, Article, Cancer Cell, Cell Growth, Controlled Study, Degradation, Growth Curve, Human, Human Tissue, Immunohistochemistry, In Vivo Study, Ionizing Radiation, Irradiation, Melanocyte, Melanoma Cell, Neoplasm, Nonhuman, Priority Journal, Protein Function, Radiosensitivity, Skin, Skin Defect, Tumor Xenograft, Animal, Genetics, Metabolism, Nude Mouse, Pathology, Physiology, Tumor Cell Line, Bcl-2-Associated X Protein, Nf-Kappa B, Transplantation, Heterologous, X-Linked Inhibitor Of Apoptosis Protein,
Affiliations:
*** IBB - CNR ***
Department of Biochemistry and Medical Biotechnology, Federico II University of Naples, Via Pansini, 5, 80131, Naples, Italy
Institute of Biostructure and Bio-Imaging, National Research Council (CNR), Naples, Italy
Department of Biomorfological and Functional Sciences, Pathology Section, Federico II University of Naples, Naples, Italy
Division of Biochemistry, Department of Biological and Environmental Sciences, University of Helsinki, Helsinki, Finland
Institute of Endocrinology and Experimental Oncology, Italian National Research Council (CNR), Naples, Italy
Italian National Cancer Institute, G. Pascale Foundation, Naples, Italy
References:
Norris, L.B., Beam, S., Multidisciplinary perspectives on melanoma treatment (2008) Updates from the 44th Annual Meeting of the American Society of Clinical Oncology, the Oncology Nurse, 1, pp. 1-
Dewey, W.C., Ling, C.C., Meyn, R.E., Radiation-induced apoptosis: Relevance to radiotherapy (1995) Int J Radiat Oncol Biol Phys, 33, pp. 781-796
Wallace, S.S., DNA damages processed by base excision repair: Biological consequences (1994) International Journal of Radiation Biology, 66 (5), pp. 579-589
Hengartner, M.O., The biochemistry of apoptosis (2000) Nature, 407, pp. 770-776
Elliott, A., Reiners Jr., J.J., Suppression of autophagy enhances the cytotoxicity of the DNAdamaging aromatic amine p-anilinoaniline (2008) Toxicol Appl Pharmacol, 232, pp. 169-179
Ogata, M., Hino, S.-I., Saito, A., Morikawa, K., Kondo, S., Kanemoto, S., Murakami, T., Imaizumi, K., Autophagy is activated for cell survival after endoplasmic reticulum stress (2006) Molecular and Cellular Biology, 26 (24), pp. 9220-9231. , DOI 10.1128/MCB.01453-06
Eskelinen, E.L., New insights into the mechanisms of macroautophagy in mammalian cells (2008) Int Rev Cell Mol Biol, 266, pp. 207-247. , Review
Baehrecke, E.H., Autophagy: Dual roles in life and death? (2005) Nature Reviews Molecular Cell Biology, 6 (6), pp. 505-510. , DOI 10.1038/nrm1666
Mathew, R., Karantza-Wadsworth, V., White, E., Role of autophagy in cancer (2007) Nature Reviews Cancer, 7 (12), pp. 961-967. , DOI 10.1038/nrc2254, PII NRC2254
Romano, M.F., Avellino, R., Petrella, A., Bisogni, R., Romano, S., Venuta, S., Rapamycin inhibits doxorubicin-induced NF-κB/Rel nuclear activity and enhances the apoptosis of melanoma cells (2004) European Journal of Cancer, 40 (18), pp. 2829-2836. , DOI 10.1016/j.ejca.2004.08.017, PII S095980490400704X
Johnson, G.E., Ivanov, V.N., Hei, T.K., Radiosensitization of melanoma cells through combined inhibition of protein regulators of cell survival (2008) Apoptosis, 13, pp. 790-802
Munshi, A., Kurland, J.F., Nishikawa, T., Chiao, P.J., Andreeff, M., Meyn, R.E., Inhibition of constitutively activated nuclear factor-κB radiosensitizers human cells (2004) Molecular Cancer Therapeutics, 3 (8), pp. 985-992
Ghosh, S., May, M.J., Kopp, E.B., NF-κB and rel proteins: Evolutionarily conserved mediators of immune responses (1998) Annual Review of Immunology, 16, pp. 225-260. , DOI 10.1146/annurev.immunol.16.1.225
Baldwin Jr., A.S., The NF-κB and IκB proteins: New discoveries and insights (1996) Annual Review of Immunology, 14, pp. 649-681
Karin, M., Cao, Y., Greten, F.R., Li, Z.-W., NF-κB in cancer: From innocent bystander to major culprit (2002) Nature Reviews Cancer, 2 (4), pp. 301-310
Baumann, M., Krause, M., Hill, R., Exploring the role of cancer stem cells in radioresistance (2008) Nature Reviews Cancer, 8 (7), pp. 545-554. , DOI 10.1038/nrc2419, PII NRC2419
Romano, S., Mallardo, M., Chiurazzi, F., Bisogni, R., D'Angelillo, A., Liuzzi, R., The effect of FK506 on transforming growth factor beta signaling and apoptosis in chronic lymphocytic leukemia B cells (2008) Haematologica, 93, pp. 75-84
Chen, A.Y., Okunieff, P., Pommier, Y., Mitchell, J.B., Mammalian DNA topoisomerase I mediates the enhancement of radiation cytotoxicity by camptothecin derivatives (1997) Cancer Research, 57 (8), pp. 1529-1536
Kabeya, Y., Mizushima, N., Ueno, T., Yamamoto, A., Kirisako, T., Noda, T., LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing (2000) EMBO J, 19, pp. 5720-5728
Chandler, J.M., Cohen, G.M., MacFarlane, M., Different subcellular distribution of caspase-3 and caspase-7 following Fas-induced apoptosis in mouse liver (1998) Journal of Biological Chemistry, 273 (18), pp. 10815-10818. , DOI 10.1074/jbc.273.18.10815
Habraken, Y., Piette, J., NF-kappaB activation by double-strand breaks (2006) Biochem Pharmacol, 72, pp. 1132-1141. , Review
Copetti, T., Bertoli, C., Dalla, E., Demarchi, F., Schneider, C., P65/RelA modulates BECN1 transcription and autophagy (2009) Mol Cell Biol, 29, pp. 2594-2608
Kim, H., Rafiuddin-Shah, M., Tu, H.-C., Jeffers, J.R., Zambetti, G.P., Hsieh, J.J.-D., Cheng, E.H.-Y., Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies (2006) Nature Cell Biology, 8 (12), pp. 1348-1358. , DOI 10.1038/ncb1499, PII NCB1499
Zhou, S., Schuetz, J.D., Bunting, K.D., Colapietro, A.-M., Sampath, J., Morris, J.J., Lagutina, I., Sorrentino, B.P., The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype (2001) Nature Medicine, 7 (9), pp. 1028-1034. , DOI 10.1038/nm0901-1028
Monzani, E., Facchetti, F., Galmozzi, E., Corsini, E., Benetti, A., Cavazzin, C., Gritti, A., La Porta, C.A.M., Melanoma contains CD133 and ABCG2 positive cells with enhanced tumourigenic potential (2007) European Journal of Cancer, 43 (5), pp. 935-946. , DOI 10.1016/j.ejca.2007.01.017, PII S0959804907000639
Hocker, T.L., Singh, M.K., Tsao, H., Melanoma genetics and therapeutic approaches in the 21st century: Moving from the benchside to the bedside (2008) J Invest Dermatol, 128, pp. 2575-2595
Poeck, H., Besch, R., Maihoefer, C., Renn, M., Tormo, D., Morskaya, S.S., 50-TriphosphatesiRNA: Turning gene silencing and Rig-I activation against melanoma (2008) Nat Med, 14, pp. 1256-1263
Sinars, C.R., Cheung-Flynn, J., Rimerman, R.A., Scammell, J.G., Smith, D.F., Clardy, J., Structure of the large FK506-binding protein FKBP51, an Hsp90-binding protein and a component of steroid receptor complexes (2003) Proceedings of the National Academy of Sciences of the United States of America, 100 (3), pp. 868-873. , DOI 10.1073/pnas.0231020100
Bouwmeester, T., Bauch, A., Ruffner, H., Angrand, P.-O., Bergamini, G., Croughton, K., Cruciat, C., Superti-Furga, G., A physical and functional map of the human TNF-α/NF-κB signal transduction pathway (2004) Nature Cell Biology, 6 (2), pp. 97-105. , DOI 10.1038/ncb1086
Naumann, U., Bahr, O., Wolburg, H., Altenberend, S., Wick, W., Liston, P., Ashkenazi, A., Weller, M., Adenoviral expression of XIAP antisense RNA induces apoptosis in glioma cells and suppresses the growth of xenografts in nude mice (2007) Gene Therapy, 14 (2), pp. 147-161. , DOI 10.1038/sj.gt.3302845, PII 3302845
Zabierowski, S.E., Herlyn, M., Learning the ABCs of Melanoma-Initiating Cells (2008) Cancer Cell, 13 (3), pp. 185-187. , DOI 10.1016/j.ccr.2008.02.015, PII S1535610808000512
Schatton, T., Murphy, G.F., Frank, N.Y., Yamaura, K., Waaga-Gasser, A.M., Gasser, M., Identification of cells initiating human melanomas (2008) Nature, 451, pp. 345-349
Baughman, G., Wiederrecht, G.J., Faith Campbell, N., Martin, M.M., Bourgeois, S., FKBP51, a novel T-cell specific immunophilin capable of calcineurin inhibition (1995) Mol Cell Biol, 15, pp. 4395-4402
Benassi, B., Zupi, G., Biroccio, A., γ-Glutamylcysteine synthetase mediates the c-Myc-dependent response to antineoplastic agents in melanoma cells (2007) Molecular Pharmacology, 72 (4), pp. 1015-1023. , http://molpharm.aspetjournals.org/cgi/reprint/72/4/1015, DOI 10.1124/mol.107.038687
Trotta, P.P., Harrison Jr., S.D., Evaluation of the antitumor activity of recombinant human γ-interferon employing human melanoma xenografts in athymic nude mice (1987) Cancer Research, 47 (20), pp. 5347-5353
Giard, D.J., Aaronson, S.A., Todaro, G.J., Arnstein, P., Kersey, J.H., Dosik, H., In vitro cultivation of human tumors: Establishment of cell lines derived from a series of solid tumors (1973) J Natl Cancer Inst, 51, pp. 1417-1423
Nap, F., Rodermond, H.M., Stap, J., Haveman, J., Van Bree, C., Clonogenic assay of cells in vitro (2006) Nat Protoc, 1, pp. 2315-2319
Staibano, S., Pepe, S., Muzio, L.L., Somma, P., Mascolo, M., Argenziano, G., Scalvenzi, M., De Rosa, G., Poly(adenosine diphosphate-ribose) polymerase 1 expression in malignant melanomas from photoexposed areas of the head and neck region (2005) Human Pathology, 36 (7), pp. 724-731. , DOI 10.1016/j.humpath.2005.04.017, PII S0046817705002315
Norris, L. B., Beam, S., Multidisciplinary perspectives on melanoma treatment (2008) Updates from the 44th Annual Meeting of the American Society of Clinical Oncology, the Oncology Nurse, 1, pp. 1-
Dewey, W. C., Ling, C. C., Meyn, R. E., Radiation-induced apoptosis: Relevance to radiotherapy (1995) Int J Radiat Oncol Biol Phys, 33, pp. 781-796
Wallace, S. S., DNA damages processed by base excision repair: Biological consequences (1994) International Journal of Radiation Biology, 66 (5), pp. 579-589
Hengartner, M. O., The biochemistry of apoptosis (2000) Nature, 407, pp. 770-776
Eskelinen, E. L., New insights into the mechanisms of macroautophagy in mammalian cells (2008) Int Rev Cell Mol Biol, 266, pp. 207-247. , Review
Baehrecke, E. H., Autophagy: Dual roles in life and death? (2005) Nature Reviews Molecular Cell Biology, 6 (6), pp. 505-510. , DOI 10. 1038/nrm1666
Romano, M. F., Avellino, R., Petrella, A., Bisogni, R., Romano, S., Venuta, S., Rapamycin inhibits doxorubicin-induced NF- B/Rel nuclear activity and enhances the apoptosis of melanoma cells (2004) European Journal of Cancer, 40 (18), pp. 2829-2836. , DOI 10. 1016/j. ejca. 2004. 08. 017, PII S095980490400704X
Johnson, G. E., Ivanov, V. N., Hei, T. K., Radiosensitization of melanoma cells through combined inhibition of protein regulators of cell survival (2008) Apoptosis, 13, pp. 790-802
Ghosh, S., May, M. J., Kopp, E. B., NF- B and rel proteins: Evolutionarily conserved mediators of immune responses (1998) Annual Review of Immunology, 16, pp. 225-260. , DOI 10. 1146/annurev. immunol. 16. 1. 225
Baldwin Jr., A. S., The NF- B and I B proteins: New discoveries and insights (1996) Annual Review of Immunology, 14, pp. 649-681
Chen, A. Y., Okunieff, P., Pommier, Y., Mitchell, J. B., Mammalian DNA topoisomerase I mediates the enhancement of radiation cytotoxicity by camptothecin derivatives (1997) Cancer Research, 57 (8), pp. 1529-1536
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Role of FK506-binding protein 51 in the control of apoptosis of irradiated melanoma cells
FK506-binding protein 51 (FKBP51) is an immunophilin with isomerase activity, which performs important biological functions in the cell. It has recently been involved in the apoptosis resistance of malignant melanoma. The aim of this study was to investigate the possible role of FKBP51 in the control of response to ionizing radiation (Rx) in malignant melanoma. FKBP51-silenced cells showed reduced clonogenic potential after irradiation compared with non-silenced cells. After Rx, we observed apoptosis in FKBP51-silenced cells and autophagy in non-silenced cells. The FKBP51-controlled radioresistance mechanism involves NF-B. FKBP51 was required for the activation of Rx-induced NF-B, which in turn inhibited apoptosis by stimulating X-linked inhibitor of apoptosis protein and promoting authophagy-mediated Bax degradation. Using a tumor-xenograft mouse model, the in vivo pretreatment of tumors with FKBP51-siRNA provoked massive apoptosis after irradiation. Immunohistochemical analysis of 10 normal skin samples and 80 malignant cutaneous melanomas showed that FKBP51 is a marker of melanocyte malignancy, correlating with vertical growth phase and lesion thickness. Finally, we provide evidence that FKBP51 targeting radiosensitizes cancer stem/initiating cells. In conclusion, our study identifies a possible molecular target for radiosensitizing therapeutic strategies against malignant melanoma. © 2010 Macmillan Publishers Limited All rights reserved.
FK506-binding protein 51 (FKBP51) is an immunophilin with isomerase activity, which performs important biological functions in the cell. It has recently been involved in the apoptosis resistance of malignant melanoma. The aim of this study was to investigate the possible role of FKBP51 in the control of response to ionizing radiation (Rx) in malignant melanoma. FKBP51-silenced cells showed reduced clonogenic potential after irradiation compared with non-silenced cells. After Rx, we observed apoptosis in FKBP51-silenced cells and autophagy in non-silenced cells. The FKBP51-controlled radioresistance mechanism involves NF-B. FKBP51 was required for the activation of Rx-induced NF-B, which in turn inhibited apoptosis by stimulating X-linked inhibitor of apoptosis protein and promoting authophagy-mediated Bax degradation. Using a tumor-xenograft mouse model, the in vivo pretreatment of tumors with FKBP51-siRNA provoked massive apoptosis after irradiation. Immunohistochemical analysis of 10 normal skin samples and 80 malignant cutaneous melanomas showed that FKBP51 is a marker of melanocyte malignancy, correlating with vertical growth phase and lesion thickness. Finally, we provide evidence that FKBP51 targeting radiosensitizes cancer stem/initiating cells. In conclusion, our study identifies a possible molecular target for radiosensitizing therapeutic strategies against malignant melanoma. © 2010 Macmillan Publishers Limited All rights reserved.
Role of FK506-binding protein 51 in the control of apoptosis of irradiated melanoma cells
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Role of FK506-binding protein 51 in the control of apoptosis of irradiated melanoma cells
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Impact Factor: 5.569
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Hangen E, Féraud O, Lachkar S, Mou H, Doti N, Fimia GM, Lam N-V, Zhu C, Godin I, Muller K, Chatzi A, Nuebel E, Ciccosanti F, Flamant S, Bénit P, Perfettini J-L, Sauvat A, Bennaceur-Griscelli A, Ser-Le Roux K, Gonin P, Tokatlidis K, Rustin P, Piacentini M, Ruvo M, Blomgren K, Kroemer G, Modjtahedi N
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Impact Factor: 13.958
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Impact Factor: 2.76
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Tornatore L, Sandomenico A, Raimondo D, Low C, Rocci A, Tralau-Stewart C, Capece D, D'Andrea D, Bua M, Boyle E, van Duin M, Zoppoli P, Jaxa-Chamiec A, Thotakura AK, Dyson J, Walker BA, Leonardi A, Chambery A, Driessen C, Sonneveld P, Morgan G, Palumbo A, Tramontano A, Rahemtulla A, Ruvo M, Franzoso G
* Cancer-selective targeting of the NF-kappaB survival pathway with GADD45beta/MKK7 inhibitors (623 views)
Cancer Cell (ISSN: 1535-6108), 2014 Oct 13; 26(4): 495-508.
Impact Factor: 23.523
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Antoniali G, Lirussi L, D'Ambrosio C, Dal Piaz F, Vascotto C, Casarano E, Marasco D, Scaloni A, Fogolari F, Tell G
* SIRT1 gene expression upon genotoxic damage is regulated by APE1 through nCaRE-promoter elements (531 views)
Mol Biol Cell (ISSN: 1059-1524), 2014 Feb 15; 25(4): 532-547.
Impact Factor: 4.466
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Doti N, Reuther C, Scognamiglio PL, Dolga AM, Plesnila N, Ruvo M, Culmsee C
* Inhibition of the AIF/CypA complex protects against intrinsic death pathways induced by oxidative stress (562 views)
Cell Death & (ISSN: 2041-4889, 2041-4889electronic), 2014 Jan 16; 5(1): e993-e993.
Impact Factor: 5.014
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Nold-Petry CA, Rudloff I, Baumer Y, Ruvo M, Marasco D, Botti P, Farkas L, Cho SX, Zepp JA, Azam T, Dinkel H, Palmer BE, Boisvert WA, Cool CD, Taraseviciene-Stewart L, Heinhuis B, Joosten LA, Dinarello CA, Voelkel NF, Nold MF
* IL-32 Promotes Angiogenesis (753 views)
J Immunol (ISSN: 0022-1767), 2014 Jan 15; 192(2): 589-602.
Impact Factor: 4.922
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Dolga AM, Netter MF, Perocchi F, Doti N, Meissner L, Tobaben S, Grohm J, Zischka H, Plesnila N, Decher N, Culmsee C
* Mitochondrial Small Conductance SK2 Channels Prevent Glutamate-induced Oxytosis and Mitochondrial Dysfunction (520 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2013 Apr 12; 288(15): 10792-10804.
Impact Factor: 4.6
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Romano S, Staibano S, Greco A, Brunetti A, Nappo G, Ilardi G, Martinelli R, Sorrentino A, Di Pace A, Mascolo M, Bisogni R, Scalvenzi M, Alfano B, Romano M
* FK506 binding protein 51 positively regulates melanoma stemness and metastatic potential (430 views) (PDF 242 views)
Cell Death & (ISSN: 2041-4889, 2041-4889electronic), 2013 Apr 4; 4(6): e578-e578.
Impact Factor: 5.333
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Rosa R, Marciano R, Malapelle U, Formisano L, Nappi L, D'Amato C, D'Amato V, Damiano V, Marf G, Del Vecchio S, Zannetti A, Greco A, De Stefano A, Carlomagno C, Veneziani BM, Troncone G, De Placido S, Bianco R
* Sphingosine Kinase 1 Overexpression Contributes to Cetuximab Resistance in Human Colorectal Cancer Models (672 views)
Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 2013 Jan 1; 19(1): 138-147.
Impact Factor: 8.193
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Ciccarelli M, Sorriento D, Franco A, Fusco A, Del Giudice C, Annunziata R, Cipolletta E, Monti MG, Dorn GW, Trimarco B, Iaccarino G
* Endothelial G protein-coupled receptor kinase 2 regulates vascular homeostasis through the control of free radical oxygen species (431 views)
Arterioscler Thromb Vasc Biol Arteriosclerosis Thrombosis And Vascular Biology (ISSN: 1079-5642, 1049-8834), 2013; 33(10): 2415-2424.
Impact Factor: 5.533
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Del Giudice R, Monti DM, Truppo E, Arciello A, Supuran CT, De Simone G, Monti SM
* Human Carbonic Anhydrase Vii Protects Cells From Oxidative Damage (366 views)
Biol Chem Biological Chemistry (ISSN: 1431-6730, 1431-1673, 1437-4315), 2013; 394(10): 1343-1348.
Impact Factor: 2.689
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Sorriento D, Fusco A, Ciccarelli M, Rungi A, Anastasio A, Carillo A, Dorn II GW, Trimarco B, Iaccarino G
* Mitochondrial G protein coupled receptor kinase 2 regulates proinflammatory responses in macrophages (385 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 2013; 587(21): 3487-3494.
Impact Factor: 3.341
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Galdiero S, Falanga A, Cantisani M, Tarallo R, della Pepa ME, D'Oriano V, Galdiero M
* Microbe-Host Interactions: Structure and Role of Gram-Negative Bacterial Porins (615 views)
Curr Protein Pept Sci (ISSN: 1389-2037, 1389-2037linking), 2012 Dec; 13(8): 843-854.
Impact Factor: 2.326
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Calabrese V, Cornelius C, Dinkova-Kostova AT, Iavicoli I, Di Paola R, Koverech A, Cuzzocrea S, Rizzarelli E, Calabrese EJ
* Cellular stress responses, hormetic phytochemicals and vitagenes in aging and longevity (3437 views)
Bba-Gen Subjects (ISSN: 0006-3002, 0925-4439, 1570-9639), 2012 May; 1822(5): 753-783.
Impact Factor: 3.733
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Vitiello M, Galdiero M, Finamore E, Galdiero S, Galdiero M
* NF-κB as a potential therapeutic target in microbial diseases (484 views)
Mol Biosyst (ISSN: 1742-206x), 2012; 8(4): 1108-1120.
Impact Factor: 3.35
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Cantisani M, Vitiello M, Falanga A, Finamore E, Galdiero M, Galdiero S
* Peptides complementary to the active loop of porin P2 from Haemophilus influenzae modulate its activity (510 views)
Int J Nanomed (ISSN: 1178-2013, 1176-9114, 1178-2013electronic), 2012; 7: 2361-2371.
Impact Factor: 3.463
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Di Paola R, Impellizzeri D, Salinaro AT, Mazzon E, Bellia F, Cavallaro M, Cornelius C, Vecchio G, Calabrese V, Rizzarelli E, Cuzzocrea S
* Administration of carnosine in the treatment of acute spinal cord injury (603 views)
Biochem Pharmacol Biochemical Pharmacology (ISSN: 1873-2968, 0006-2952), 2011 Nov 15; 82(10): 1478-1489.
Impact Factor: 4.705
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Palmieri G, Bergamo P, Luini A, Ruvo M, Gogliettino M, Langella E, Saviano M, Hegde RN, Sandomenico A, Rossi M
* Acylpeptide hydrolase inhibition as targeted strategy to induce proteasomal down-regulation (490 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2011 Oct 10; 6(10): e25888-e25888.
Impact Factor: 4.092
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Calabrese V, Cornelius C, Cuzzocrea S, Iavicoli I, Rizzarelli E, Calabrese EJ
* Hormesis, cellular stress response and vitagenes as critical determinants in aging and longevity (880 views)
Molecular Aspects Of Medicine (ISSN: 1872-9452, 0098-2997), 2011 Sep; 32(4-6): 279-304.
Impact Factor: 9.97
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Janda E, Palmieri C, Pisano A, Pontoriero M, Iaccino E, Falcone C, Fiume G, Gaspari M, Nevolo M, Di Salle E, Rossi A, De Laurentiis A, Greco A, Di Napoli D, Verheij E, Britti D, Lavecchia L, Quinto I, Scala G
* Btk regulation in human and mouse B cells via protein kinase C phosphorylation of IBtkγ (451 views)
Blood (ISSN: 0006-4971, 0006-6497, 0390-6078), 2011 Jun 16; 117(24): 6520-6531.
Impact Factor: 9.898
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Ciccarelli M, Sorriento D, Cipolletta E, Santulli G, Fusco A, Zhou R-H, Eckhart AD, Peppel K, Koch WJ, Trimarco B, Iaccarino G
* Impaired neoangiogenesis in β2-adrenoceptor gene-deficient mice: Restoration by intravascular human β2-adrenoceptor gene transfer and role of NFkB and CREB transcription factors (368 views)
Br J Pharmacol British Journal Of Pharmacology (ISSN: 0007-1188), 2011; 162(3): 712-721.
Impact Factor: 4.409
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Sorriento D, Santulli G, Fusco A, Anastasio A, Trimarco B, Iaccarino G
* Intracardiac injection of AdGRK5-NT reduces left ventricular hypertrophy by inhibiting NF-κB-Dependent hypertrophic gene expression (457 views)
Hypertensionhypertension (ISSN: 0194-911x), 2010; 56(4): 696-704.
Impact Factor: 6.908
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Sorriento D, Iaccarino G, Trimarco B
The role of the transcription factor nuclear factor kappa B in the regulation of cardiac hypertrophy (410 views)
High Blood Press Cardiovasc Prev High Blood Pressure And Cardiovascular Prevention (ISSN: 1120-9879), 2010; 17(4): 209-217.
Impact Factor: 0
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Vitiello M, Finamore E, Falanga A, Raieta K, Cantisani M, Galdiero F, Pedone C, Galdiero M, Galdiero S
* Viral fusion peptides induce several signal transduction pathway activations that are essential for interleukin-10 and beta-interferon production (476 views)
Intervirology (ISSN: 1423-0100, 0300-5526), 2010; 53(6): 381-389.
Impact Factor: 1.756
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Marasco D, Stilo R, Sandomenico A, Monti SM, Tizzano B, De Capua A, Varricchio E, Liguoro D, Zotti T, Formisano S, Ruvo M, Vito P
* Generation And Functional Characterization Of A Bcl10-Inhibitory Peptide That Represses Nf-Kappa B Activation (456 views)
Biochem J (ISSN: 0264-6021, 1470-8728electronic, 0264-6021linking), 2009 Sep 15; 422(3): 553-561.
Impact Factor: 5.155
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Sandomenico A, Monti SM, Sabatella M, De Capua A, Tornatore L, Doti N, Viparelli F, Dathan NA, Pedone C, Ruvo M, Marasco D
* Protein-protein interactions: a simple strategy to identify binding sites and peptide antagonists (558 views)
Chem Biol Drug Des (ISSN: 1747-0285, 1747-0277), 2009 May; 73(5): 483-493.
Impact Factor: 2.473
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Cho WG, Albuquerque RJ, Kleinman ME, Tarallo V, Greco A, Nozaki M, Green MG, Baffi JZ, Ambati BK, De Falco M, Alexander JS, Brunetti A, De Falco S, Ambati J
* Small interfering RNA-induced TLR3 activation inhibits blood and lymphatic vessel growth (402 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2009 Apr 28; 106(17): 7137-7142.
Impact Factor: 9.432
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Sorriento D, Campanile A, Santulli G, Leggiero E, Pastore L, Trimarco B, Iaccarino G
* A new synthetic protein, TAT-RH, inhibits tumor growth through the regulation of NFκB activity (358 views)
Mol Cancermolecular Cancer (ISSN: 1476-4598), 2009; 8: N/D-N/D.
Impact Factor: 4.16
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Chiechio S, Zammataro M, Morales ME, Busceti CL, Drago F, Th Gereau RW, Copani A, Nicoletti F
* Epigenetic modulation of mGlu2 receptors by histone deacetylase inhibitors in the treatment of inflammatory pain (452 views)
Mol Pharmacol (ISSN: 0026-895x), 2009; 75(5): 1014-1020.
Impact Factor: 4.531
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Calabrese V, Cornelius C, Mancuso C, Pennisi G, Calafato S, Bellia F, Bates TE, Giuffrida Stella AM, Schapira T, Dinkova Kostova AT, Rizzarelli E
* Cellular stress response: a novel target for chemoprevention and nutritional neuroprotection in aging, neurodegenerative disorders and longevity (1156 views)
Neurochemical Research (ISSN: 1573-6903, 0364-3190), 2008 Dec; 33(12): 2444-2471.
Impact Factor: 2.26
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Malaguarnera R, Vella V, Pandini G, Sanfilippo M, Pezzino V, Vigneri R, Frasca F
* TAp73α increases p53 tumor suppressor activity in thyroid cancer cells via the inhibition of Mdm2-mediated degradation (419 views)
Mol Cancer Res (ISSN: 1541-7786), 2008; 6(1): 64-77.
Impact Factor: 4.533
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Sorriento D, Ciccarelli M, Santulli G, Campanile A, Altobelli GG, Cimini V, Galasso G, Astone D, Piscione F, Pastore L, Trimarco B, Iaccarino G
* The G-protein-coupled receptor kinase 5 inhibits NFκB transcriptional activity by inducing nuclear accumulation of IκBα (438 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2008; 105(46): 17818-17823.
Impact Factor: 9.38
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Marrazzo A, Caraci F, Salinaro ET, Su TP, Copani A, Ronsisvalle G
* Neuroprotective effects of sigma-1 receptor agonists against beta-amyloid-induced toxicity (584 views)
Neuroreport (ISSN: 0959-4965), 2005 Sep 1; 16(11): 1223-1226.
Impact Factor: 1.995
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Benedetti E, Pedone C
* Cyclolinopeptide A: inhibitor, immunosuppressor or other? (566 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2005 May; 11(5): 268-272.
Impact Factor: 1.803
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Filippo C, Mariangela C, Giuseppina F, Pier Luigi C, Angelo B, Marco C, Giuseppe B, Paolo B, Ferdinando N, Agata C, Maria Angela S
* Nicergoline, a drug used for age-dependent cognitive impairment, protects cultured neurons against β-amyloid toxicity (796 views)
Brain Res (ISSN: 0006-8993), 2005; 1047(1): 30-37.
Impact Factor: 2.296
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Borgatti M, Finotti A, Romanelli A, Saviano M, Bianchi N, Lampronti I, Lambertini E, Penolazzi L, Nastruzzi C, Mischiati C, Piva R, Pedone C, Gambari R
* Peptide nucleic acids (PNA)-DNA chimeras targeting transcription factors as a tool to modify gene expression (478 views)
Curr Drug Targets (ISSN: 1389-4501), 2004 Nov; 5(8): 735-744.
Impact Factor: 4.104
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Mischiati C, Sereni A, Finotti A, Breda L, Cortesi R, Nastruzzi C, Romanelli A, Saviano M, Bianchi N, Pedone C, Borgatti M, Gambari R
* Complexation to cationic microspheres of double-stranded peptide nucleic acid-DNA chimeras exhibiting decoy activity (361 views)
Journal Of Biomedical Science (ISSN: 1021-7770), 2004 Sep; 11(5): 697-704.
Impact Factor: 1.567
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Penolazzi L, Borgatti M, Lambertini E, Mischiati C, Finotti A, Romanelli A, Saviano M, Pedone C, Piva R, Gambari R
* Peptide nucleic acid-DNA decoy chimeras targeting NF-kappa B transcription factors: Induction of apoptosis in human primary osteoclasts (312 views)
International Journal Of Molecular Medicine (ISSN: 1107-3756), 2004 Sep; 14(2): 145-152.
Impact Factor: 3.19
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Galdiero M, Vitiello M, Galdiero S
* Eukaryotic cell signaling and transcriptional activation induced by bacterial porins (443 views)
Fems Microbiology Letters (ISSN: 0378-1097), 2003 Sep 12; 226(1): 57-64.
Impact Factor: 1.932
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Del Vecchio S, Zannetti A, Aloj L, Caracò C, Ciarmiello A, Salvatore M
* Inhibition of early Tc-99m-MIBI uptake by Bcl-2 anti-apoptotic protein overexpression in untreated breast carcinoma (527 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2003 Jun; 30(6): 879-887.
Impact Factor: 3.324
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Borgatti M, Romanelli A, Saviano M, Pedone C, Lampronti I, Breda L, Nastruzzi C, Bianchi N, Mischiati C, Gambari R
* Resistance of decoy PNA-DNA chimeras to enzymatic degradation in cellular extracts and serum (372 views)
Oncology Research (ISSN: 0965-0407), 2003; 13(5): 279-287.
Impact Factor: 1.794
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Borgatti M, Breda L, Cortesi R, Nastruzzi C, Romanelli A, Saviano M, Bianchi N, Mischiati C, Pedone C, Gambari R
* Cationic Liposomes As Delivery Systems For Double-Stranded Pna-Dna Chimeras Exhibiting Decoy Activity Against Nf-Kappab Transcription Factors (416 views)
Biochem Pharmacol Biochemical Pharmacology (ISSN: 1873-2968, 0006-2952), 2002 Sep 15; 64(4): 609-616.
Impact Factor: 3.542
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Romanelli A, Pedone C, Saviano M, Bianchi N, Borgatti M, Mischiati C, Gambari R
* Molecular interactions between nuclear factor κB (NF-κB) transcription factors and a PNA-DNA chimera mimicking NF-κB binding sites (431 views)
Eur J Biochem (ISSN: 0014-2956, 0014-2956print, 0014-2956linking), 2001 Dec; 268(23): 6066-6075.
Impact Factor: 2.849
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Vitiello M, Finamore E, Falanga A, Raieta K, Cantisani M, Galdiero F, Pedone C, Galdiero M, Galdiero S
* Fusion in Coq (479 views)
Lecture Notes In Computer Science (ISSN: 0302-9743, 0302-974335404636319783540463634, 0302-974335402975459783540297543), 2001; 2178LNCS: 583-596.
Impact Factor: 0.415
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Saviano M, Romanelli A, Bucci E, Pedone C, Mischiati C, Bianchi N, Feriotto G, Borgatti M, Gambari R
Computational procedures to explain the different biological activity of DNA/DNA, DNA/PNA and PNA/PNA hybrid molecules mimicking NF-κB binding sites (493 views)
J Biomol Struct Dyn (ISSN: 0739-1102, 1538-0254electronic, 0739-1102linking), 2000 Dec; 18(3): 353-362.
Impact Factor: 1.826
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47 Records (45 excluding Abstracts).
Total impact factor: 222.398 (212.051 excluding Abstracts).
Total 5 year impact factor: 233.095 (222.471 excluding Abstracts).
Total impact factor: 222.398 (212.051 excluding Abstracts).
Total 5 year impact factor: 233.095 (222.471 excluding Abstracts).
434 views. Last view on Tuesday 28 February 2023, 13:27:10
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