Structural insights into the interaction between the Cripto CFC domain and the ALK4 receptor (456 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 175-183.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 1.807, 5-year impact factor: 1.872
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-63449092615&partnerID=40&md5=431525a10b8c03d95a6de0fbd614fea1
Keywords: Conformational Analysis, Docking, Egf-Cfc Family, Homology Modelling, Activin, Activin Receptor, Cysteine, Disulfide, Epidermal Growth Factor, Protein, Protein Cripto, Transforming Growth Factor Beta, Unclassified Drug, Acvr1b Protein, Human, Membrane Protein, Tdgf1 Protein, Tumor Protein, Binding Affinity, Carcinogenesis, Conference Paper, Controlled Study, Embryo Development, Molecular Docking, Molecular Interaction, Mutagenesis, Nuclear Magnetic Resonance, Priority Journal, Protein Domain, Protein Expression, Protein Protein Interaction, Structure Analysis, Synthesis, Amino Acid Sequence, Article, Chemistry, High Performance Liquid Chromatography, Mass Spectrometry, Metabolism, Molecular Genetics, Nuclear Magnetic Resonance Spectroscopy, Protein Binding, Protein Secondary Structure, Protein Tertiary Structure, Type I, High Pressure Liquid, Membrane Glycoproteins, Molecular Sequence Data, Neoplasm Proteins, Protein Structure, Type I Chemistry Metabolism, Epidermal Growth Factor Chemistry Metabolism, Gpi-Linked Proteins, Intercellular Signaling Peptides And Proteins, Membrane Glycoproteins Chemistry Metabolism, Neoplasm Proteins Chemistry Metabolism,
Affiliations:
*** IBB - CNR ***
Dipartimento di Chimica, Universita Federico II, Complesso Universitario MSA, via Cintia 45, 80126, Napoli, Italy.
Istituto di Biostrutture e Bioimmagini, CNR, via Mezzocannone 16, 80134 Napoli, Italy
Dipartimento di Scienze Applicate, Università degli Studi di Napoli Parthenope, Centro Direzionale Isola C4, 80143 Napoli, Italy
References:
Schiffer, S.G., Foley, S., Kaffashan, A., Hronowski, X., Zichittella, A.E., Yeo, C.Y., Miatkowski, K., Williams, K.P., Fucosylation of Cripto is required for its ability to facilitate nodal signaling (2001) J. Biol. Chem, 276 (41), pp. 37769-3777
Yan, Y.T., Liu, J.J., Luo, Y.E.C., Haltiwanger, R.S., Abate-Shen, C., Shen, M.M., Dual roles of Cripto as a ligand and coreceptor in the nodal signaling pathway (2002) Mol. Cell Biol, 22 (13), pp. 4439-4449
Adkins, H.B., Bianco, C., Schiffer, S.G., Rayhorn, P., Zafari, M., Cheung, A.E., Orozco, O., Sanicola, M., Antibody blockade of the Cripto CFC domain suppresses tumor cell growth in vivo (2003) J. Clin. Invest, 112 (4), pp. 575-587
Saloman, D.S., Bianco, C., Ebert, A.D., Khan, N.I., De Santis, M., Normanno, N., Wechselberger, C., Persico, G., The EGF-CFC family: Novel epidermal growth factor-related proteins in development and cancer (2000) Endocr. Relat. Cancer, 7 (4), pp. 199-226
Shen, M.M., Decrypting the role of Cripto in tumorigenesis (2003) J. Clin. Invest, 112 (4), pp. 500-502
Parisi, S., D'Andrea, D., Lago, C.T., Adamson, E.D., Persico, M.G., Minchiotti, G., Nodal-dependent Cripto signaling promotes cardiomyogenesis and redirects the neural fate of embryonic stem cells (2003) J. Cell Biol, 163 (2), pp. 303-314
Sakuma, R., Ohnishi Yi, Y., Meno, C., Fujii, H., Juan, H., Takeuchi, J., Ogura, T., Hamada, H., Inhibition of Nodal signalling by Lefty mediated through interaction with common receptors and efficient diffusion (2002) Genes Cells, 7 (4), pp. 401-412
Schier, A.F., Nodal signaling in vertebrate development (2003) Annu. Rev. Cell Dev. Biol, 19, pp. 589-621
Yeo, C., Whitman, M., Nodal signals to Smads through Cripto-dependent and Cripto-independent mechanisms (2001) Mol. Cells, 7 (5), pp. 949-957
Chen, C., Ware, S.M., Sato, A., Houston-Hawkins, D.E., Habas, R., Matzuk, M.M., Shen, M.M., Brown, C.W., The Vg1-related protein Gdf3 acts in a Nodal signaling pathway in the pre-gastrulation mouse embryo (2006) Development, 133 (2), pp. 319-329
Cheng, S.K., Olale, F., Bennett, J.T., Brivanlou, A.H., Schier, A.F., EGF-CFC proteins are essential coreceptors for the TGF-beta signals Vg1 and GDF1 (2003) Genes Dev, 17 (1), pp. 31-36
Gray, P.C., Harrison, C.A., Vale, W., Cripto forms a complex with activin and type II activin receptors and can block activin signaling (2003) Proc. Natl. Acad. Sci. U.S.A, 100 (9), pp. 5193-5198
Marasco, D., Saporito, A., Ponticelli, S., Chambery, A., De Falco, S., Pedone, C., Minchiotti, G., Ruvo, M., Chemical synthesis ofmouse cripto CFC variants (2006) Proteins, 64 (3), pp. 779-788
Risbridger, G.P., Schmitt, J.F., Robertson, D.M., Activins and inhibins in endocrine and other tumors (2001) Endocr. Rev, 22 (6), pp. 836-858
Shani, G., Fischer, W.H., Justice, N.J., Kelber, J.A., Vale, W., Gray, P.C., GRP78 and Cripto form a complex at the cell surface and collaborate to inhibit transforming growth factor beta signalling and enhance cell growth (2008) Mol. Cell Biol, 28 (2), pp. 666-677
Bianco, C., Normanno, N., Salomon, D.S., Ciardiello, F., Role of the cripto (EGF-CFC) family in embryogenesis and cancer (2004) Growth Factors, 22 (3), pp. 133-139
Gray, P.C., Shani, G., Aung, K., Kelber, J., Vale, W., Cripto binds transforming growth factor beta (TGF-beta) and inhibits TGF-beta signalling (2006) Mol. Cell Biol, 26 (24), pp. 9268-9278
Lin, S.J., Lerch, T.F., Cook, R.W., Jardetzky, T.S., Woodruff, T.K., The structural basis of TGF-beta, bone morphogenetic protein, and activin ligand binding (2006) Reproduction, 132 (2), pp. 179-190
Calvanese, L., Saporito, A., Marasco, D., D'Auria, G., Minchiotti, G., Pedone, C., Paolillo, L., Ruvo, M., Solution structure of mouse Cripto CFC domain and its inactive variant Trp107Ala (2006) J. Med. Chem, 49 (24), pp. 7054-7062
Kirsch, T., Sebald, W., Dreyer, M.K., Crystal structure of the BMP-2-BRIA ectodomain complex (2000) Nat. Struct. Biol, 7 (6), pp. 492-496
Fields, G.B., Noble, R.L., Solid phase peptide synthesis utilizing 9- fluorenylmethoxycarbonyl amino acids (1990) Int. J. Pept. Protein Res, 35 (3), pp. 161-214
Bax, A., Davis, D.G., MLEV-17-based two-dimensional homonuclear magnetization transfer spectroscopy (1985) J. Magn. Reson, 65, pp. 355-360
Bax, A., Practical aspects of two-dimensional transverse NOE spectroscopy (1985) J. Magn. Reson, 63, pp. 207-213
States, D.J., Haberhorn, R.A., Ruben, D.J., A two-dimensional nuclear Overhauser experiment with pure absorption phase in four quadrants (1982) J. Magn. Reson, 48, pp. 286-292
Piotto, M., Saudek, V., Sklenar, V., Gradient-tailored excitation for single-quantum NMR spectroscopy of aqueous solutions (1992) J. Biomol. NMR, 2 (6), pp. 661-665
Delaglio, F., Grzesiek, S., Vuister, G.W., Zhu, G., Pfeifer, J., Bax, A., NMRPipe: A multidimensional spectral processing system based on UNIX pipes (1995) J. Biomol. NMR, 6 (3), pp. 277-293
Johnson, B.A., Using NMRView to visualize and analyze the NMR spectra of macromolecules (2004) Methods Mol. Biol, 278, pp. 313-352
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Minchiotti, G., Manco, G., Parisi, S., Lago, C.T., Rosa, F., Persico, M.G., Structure-function analysis of the EGF-CFC family member Cripto identifies residues essential for nodal signalling (2001) Development, 128 (22), pp. 4501-4510
Wishart, D.S., Sykes, B.D., Richards, F.M., Relationship between nuclear magnetic resonance chemical shift and protein secondary structure (1991) J. Mol. Biol, 222 (2), pp. 311-333
Foley, S.F., van Vlijmen, H.W., Boynton, R.E., Adkins, H.B., Cheung, A.E., Singh, J., Sanicola, M., Wen, D., The CRIPTO/FRL-1/CRYPTIC (CFC) domain of human Cripto. Functional and structural insights through disulfide structure analysis (2003) Eur. J. Biochem, 270 (17), pp. 3610-3618
Kingsley, D.M., The TGF-beta superfamily: New members, new receptors, and new genetic tests of function in different organisms (1994) Genes Dev, 8 (2), pp. 133-146
Harrison, C.A., Gray, P.C., Koerber, S.C., Fischer, W., Vale, W., Identification of a functional binding site for activin on the type I receptor ALK4 (2003) J. Biol. Chem, 278 (23), pp. 21129-21135
Innis, C.A., Shi, J., Blundell, T.L., Evolutionary trace analysis of TGF-beta and related growth factors: Implications for site-directed mutagenesis (2000) Protein Eng, 13 (12), pp. 839-847
Sternberg, M.J., Gabb, H.A., Jackson, R.M., Moont, G., Protein-protein docking. Generation and filtering of complexes (2000) Methods Mol. Biol, 143, pp. 399-415
Fernandez-Recio, J., Romero, A., Sancho, J., Energetics of a hydrogen bond (charged and neutral) and of a cation-pi interaction in apoflavodoxin (1999) J. Mol. Biol, 290 (1), pp. 319-330
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Schiffer, S. G., Foley, S., Kaffashan, A., Hronowski, X., Zichittella, A. E., Yeo, C. Y., Miatkowski, K., Williams, K. P., Fucosylation of Cripto is required for its ability to facilitate nodal signaling (2001) J. Biol. Chem, 276 (41), pp. 37769-3777
Yan, Y. T., Liu, J. J., Luo, Y. E. C., Haltiwanger, R. S., Abate-Shen, C., Shen, M. M., Dual roles of Cripto as a ligand and coreceptor in the nodal signaling pathway (2002) Mol. Cell Biol, 22 (13), pp. 4439-4449
Adkins, H. B., Bianco, C., Schiffer, S. G., Rayhorn, P., Zafari, M., Cheung, A. E., Orozco, O., Sanicola, M., Antibody blockade of the Cripto CFC domain suppresses tumor cell growth in vivo (2003) J. Clin. Invest, 112 (4), pp. 575-587
Saloman, D. S., Bianco, C., Ebert, A. D., Khan, N. I., De Santis, M., Normanno, N., Wechselberger, C., Persico, G., The EGF-CFC family: Novel epidermal growth factor-related proteins in development and cancer (2000) Endocr. Relat. Cancer, 7 (4), pp. 199-226
Shen, M. M., Decrypting the role of Cripto in tumorigenesis (2003) J. Clin. Invest, 112 (4), pp. 500-502
Schier, A. F., Nodal signaling in vertebrate development (2003) Annu. Rev. Cell Dev. Biol, 19, pp. 589-621
Chen, C., Ware, S. M., Sato, A., Houston-Hawkins, D. E., Habas, R., Matzuk, M. M., Shen, M. M., Brown, C. W., The Vg1-related protein Gdf3 acts in a Nodal signaling pathway in the pre-gastrulation mouse embryo (2006) Development, 133 (2), pp. 319-329
Cheng, S. K., Olale, F., Bennett, J. T., Brivanlou, A. H., Schier, A. F., EGF-CFC proteins are essential coreceptors for the TGF-beta signals Vg1 and GDF1 (2003) Genes Dev, 17 (1), pp. 31-36
Gray, P. C., Harrison, C. A., Vale, W., Cripto forms a complex with activin and type II activin receptors and can block activin signaling (2003) Proc. Natl. Acad. Sci. U. S. A, 100 (9), pp. 5193-5198
Risbridger, G. P., Schmitt, J. F., Robertson, D. M., Activins and inhibins in endocrine and other tumors (2001) Endocr. Rev, 22 (6), pp. 836-858
Gray, P. C., Shani, G., Aung, K., Kelber, J., Vale, W., Cripto binds transforming growth factor beta (TGF-beta) and inhibits TGF-beta signalling (2006) Mol. Cell Biol, 26 (24), pp. 9268-9278
Lin, S. J., Lerch, T. F., Cook, R. W., Jardetzky, T. S., Woodruff, T. K., The structural basis of TGF-beta, bone morphogenetic protein, and activin ligand binding (2006) Reproduction, 132 (2), pp. 179-190
Fields, G. B., Noble, R. L., Solid phase peptide synthesis utilizing 9- fluorenylmethoxycarbonyl amino acids (1990) Int. J. Pept. Protein Res, 35 (3), pp. 161-214
Bax, A., Davis, D. G., MLEV-17-based two-dimensional homonuclear magnetization transfer spectroscopy (1985) J. Magn. Reson, 65, pp. 355-360
States, D. J., Haberhorn, R. A., Ruben, D. J., A two-dimensional nuclear Overhauser experiment with pure absorption phase in four quadrants (1982) J. Magn. Reson, 48, pp. 286-292
Johnson, B. A., Using NMRView to visualize and analyze the NMR spectra of macromolecules (2004) Methods Mol. Biol, 278, pp. 313-352
Altschul, S. F., Madden, T. L., Schaffer, A. A., Zhang, J., Zhang, Z., Miller, W., Lipman, D. J., Gapped BLAST and PSI-BLAST: A new generation of protein database search programs (1997) Nucleic Acids Res, 25 (17), pp. 3389-3402
Jones, D. T., GenTHREADER: An efficient and reliable protein fold recognition method for genomic sequences (1999) J. Mol. Biol, 287 (4), pp. 797-815
Thompson, J. D., Higgins, D. G., Gibson, T. J., CLUSTAL W: Improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice (1994) Nucleic Acids Res, 22 (22), pp. 4673-4680
Hooft, R. W., Vriend, G., Sander, C., Abola, E. E., Errors in protein structures (1996) Nature, 381 (6580), p. 272
8 (1): 52-56, 29Bowie, J. U., Luthy, R., Eisenberg, D., A method to identify protein sequences that fold into a known three-dimensional structure (1991) Science, 253 (5016), pp. 164-170
Gabb, H. A., Jackson, R. M., Sternberg, M. J., Modelling protein docking using shape complementarity, electrostatics and biochemical information (1997) J. Mol. Biol, 272 (1), pp. 106-120
Jackson, R. M., Gabb, H. A., Sternberg, M. J., Rapid refinement of protein interfaces incorporating solvation: Application to the docking problem (1998) J. Mol. Biol, 276 (1), pp. 265-285
Wishart, D. S., Sykes, B. D., Richards, F. M., Relationship between nuclear magnetic resonance chemical shift and protein secondary structure (1991) J. Mol. Biol, 222 (2), pp. 311-333
Foley, S. F., van Vlijmen, H. W., Boynton, R. E., Adkins, H. B., Cheung, A. E., Singh, J., Sanicola, M., Wen, D., The CRIPTO/FRL-1/CRYPTIC (CFC) domain of human Cripto. Functional and structural insights through disulfide structure analysis (2003) Eur. J. Biochem, 270 (17), pp. 3610-3618
Kingsley, D. M., The TGF-beta superfamily: New members, new receptors, and new genetic tests of function in different organisms (1994) Genes Dev, 8 (2), pp. 133-146
Harrison, C. A., Gray, P. C., Koerber, S. C., Fischer, W., Vale, W., Identification of a functional binding site for activin on the type I receptor ALK4 (2003) J. Biol. Chem, 278 (23), pp. 21129-21135
Innis, C. A., Shi, J., Blundell, T. L., Evolutionary trace analysis of TGF-beta and related growth factors: Implications for site-directed mutagenesis (2000) Protein Eng, 13 (12), pp. 839-847
Sternberg, M. J., Gabb, H. A., Jackson, R. M., Moont, G., Protein-protein docking. Generation and filtering of complexes (2000) Methods Mol. Biol, 143, pp. 399-415
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 175-183.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 1.807, 5-year impact factor: 1.872
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-63449092615&partnerID=40&md5=431525a10b8c03d95a6de0fbd614fea1
Keywords: Conformational Analysis, Docking, Egf-Cfc Family, Homology Modelling, Activin, Activin Receptor, Cysteine, Disulfide, Epidermal Growth Factor, Protein, Protein Cripto, Transforming Growth Factor Beta, Unclassified Drug, Acvr1b Protein, Human, Membrane Protein, Tdgf1 Protein, Tumor Protein, Binding Affinity, Carcinogenesis, Conference Paper, Controlled Study, Embryo Development, Molecular Docking, Molecular Interaction, Mutagenesis, Nuclear Magnetic Resonance, Priority Journal, Protein Domain, Protein Expression, Protein Protein Interaction, Structure Analysis, Synthesis, Amino Acid Sequence, Article, Chemistry, High Performance Liquid Chromatography, Mass Spectrometry, Metabolism, Molecular Genetics, Nuclear Magnetic Resonance Spectroscopy, Protein Binding, Protein Secondary Structure, Protein Tertiary Structure, Type I, High Pressure Liquid, Membrane Glycoproteins, Molecular Sequence Data, Neoplasm Proteins, Protein Structure, Type I Chemistry Metabolism, Epidermal Growth Factor Chemistry Metabolism, Gpi-Linked Proteins, Intercellular Signaling Peptides And Proteins, Membrane Glycoproteins Chemistry Metabolism, Neoplasm Proteins Chemistry Metabolism,
Affiliations:
*** IBB - CNR ***
Dipartimento di Chimica, Universita Federico II, Complesso Universitario MSA, via Cintia 45, 80126, Napoli, Italy.
Istituto di Biostrutture e Bioimmagini, CNR, via Mezzocannone 16, 80134 Napoli, Italy
Dipartimento di Scienze Applicate, Università degli Studi di Napoli Parthenope, Centro Direzionale Isola C4, 80143 Napoli, Italy
References:
Schiffer, S.G., Foley, S., Kaffashan, A., Hronowski, X., Zichittella, A.E., Yeo, C.Y., Miatkowski, K., Williams, K.P., Fucosylation of Cripto is required for its ability to facilitate nodal signaling (2001) J. Biol. Chem, 276 (41), pp. 37769-3777
Yan, Y.T., Liu, J.J., Luo, Y.E.C., Haltiwanger, R.S., Abate-Shen, C., Shen, M.M., Dual roles of Cripto as a ligand and coreceptor in the nodal signaling pathway (2002) Mol. Cell Biol, 22 (13), pp. 4439-4449
Adkins, H.B., Bianco, C., Schiffer, S.G., Rayhorn, P., Zafari, M., Cheung, A.E., Orozco, O., Sanicola, M., Antibody blockade of the Cripto CFC domain suppresses tumor cell growth in vivo (2003) J. Clin. Invest, 112 (4), pp. 575-587
Saloman, D.S., Bianco, C., Ebert, A.D., Khan, N.I., De Santis, M., Normanno, N., Wechselberger, C., Persico, G., The EGF-CFC family: Novel epidermal growth factor-related proteins in development and cancer (2000) Endocr. Relat. Cancer, 7 (4), pp. 199-226
Shen, M.M., Decrypting the role of Cripto in tumorigenesis (2003) J. Clin. Invest, 112 (4), pp. 500-502
Parisi, S., D'Andrea, D., Lago, C.T., Adamson, E.D., Persico, M.G., Minchiotti, G., Nodal-dependent Cripto signaling promotes cardiomyogenesis and redirects the neural fate of embryonic stem cells (2003) J. Cell Biol, 163 (2), pp. 303-314
Sakuma, R., Ohnishi Yi, Y., Meno, C., Fujii, H., Juan, H., Takeuchi, J., Ogura, T., Hamada, H., Inhibition of Nodal signalling by Lefty mediated through interaction with common receptors and efficient diffusion (2002) Genes Cells, 7 (4), pp. 401-412
Schier, A.F., Nodal signaling in vertebrate development (2003) Annu. Rev. Cell Dev. Biol, 19, pp. 589-621
Yeo, C., Whitman, M., Nodal signals to Smads through Cripto-dependent and Cripto-independent mechanisms (2001) Mol. Cells, 7 (5), pp. 949-957
Chen, C., Ware, S.M., Sato, A., Houston-Hawkins, D.E., Habas, R., Matzuk, M.M., Shen, M.M., Brown, C.W., The Vg1-related protein Gdf3 acts in a Nodal signaling pathway in the pre-gastrulation mouse embryo (2006) Development, 133 (2), pp. 319-329
Cheng, S.K., Olale, F., Bennett, J.T., Brivanlou, A.H., Schier, A.F., EGF-CFC proteins are essential coreceptors for the TGF-beta signals Vg1 and GDF1 (2003) Genes Dev, 17 (1), pp. 31-36
Gray, P.C., Harrison, C.A., Vale, W., Cripto forms a complex with activin and type II activin receptors and can block activin signaling (2003) Proc. Natl. Acad. Sci. U.S.A, 100 (9), pp. 5193-5198
Marasco, D., Saporito, A., Ponticelli, S., Chambery, A., De Falco, S., Pedone, C., Minchiotti, G., Ruvo, M., Chemical synthesis ofmouse cripto CFC variants (2006) Proteins, 64 (3), pp. 779-788
Risbridger, G.P., Schmitt, J.F., Robertson, D.M., Activins and inhibins in endocrine and other tumors (2001) Endocr. Rev, 22 (6), pp. 836-858
Shani, G., Fischer, W.H., Justice, N.J., Kelber, J.A., Vale, W., Gray, P.C., GRP78 and Cripto form a complex at the cell surface and collaborate to inhibit transforming growth factor beta signalling and enhance cell growth (2008) Mol. Cell Biol, 28 (2), pp. 666-677
Bianco, C., Normanno, N., Salomon, D.S., Ciardiello, F., Role of the cripto (EGF-CFC) family in embryogenesis and cancer (2004) Growth Factors, 22 (3), pp. 133-139
Gray, P.C., Shani, G., Aung, K., Kelber, J., Vale, W., Cripto binds transforming growth factor beta (TGF-beta) and inhibits TGF-beta signalling (2006) Mol. Cell Biol, 26 (24), pp. 9268-9278
Lin, S.J., Lerch, T.F., Cook, R.W., Jardetzky, T.S., Woodruff, T.K., The structural basis of TGF-beta, bone morphogenetic protein, and activin ligand binding (2006) Reproduction, 132 (2), pp. 179-190
Calvanese, L., Saporito, A., Marasco, D., D'Auria, G., Minchiotti, G., Pedone, C., Paolillo, L., Ruvo, M., Solution structure of mouse Cripto CFC domain and its inactive variant Trp107Ala (2006) J. Med. Chem, 49 (24), pp. 7054-7062
Kirsch, T., Sebald, W., Dreyer, M.K., Crystal structure of the BMP-2-BRIA ectodomain complex (2000) Nat. Struct. Biol, 7 (6), pp. 492-496
Fields, G.B., Noble, R.L., Solid phase peptide synthesis utilizing 9- fluorenylmethoxycarbonyl amino acids (1990) Int. J. Pept. Protein Res, 35 (3), pp. 161-214
Bax, A., Davis, D.G., MLEV-17-based two-dimensional homonuclear magnetization transfer spectroscopy (1985) J. Magn. Reson, 65, pp. 355-360
Bax, A., Practical aspects of two-dimensional transverse NOE spectroscopy (1985) J. Magn. Reson, 63, pp. 207-213
States, D.J., Haberhorn, R.A., Ruben, D.J., A two-dimensional nuclear Overhauser experiment with pure absorption phase in four quadrants (1982) J. Magn. Reson, 48, pp. 286-292
Piotto, M., Saudek, V., Sklenar, V., Gradient-tailored excitation for single-quantum NMR spectroscopy of aqueous solutions (1992) J. Biomol. NMR, 2 (6), pp. 661-665
Delaglio, F., Grzesiek, S., Vuister, G.W., Zhu, G., Pfeifer, J., Bax, A., NMRPipe: A multidimensional spectral processing system based on UNIX pipes (1995) J. Biomol. NMR, 6 (3), pp. 277-293
Johnson, B.A., Using NMRView to visualize and analyze the NMR spectra of macromolecules (2004) Methods Mol. Biol, 278, pp. 313-352
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Thompson, J. D., Higgins, D. G., Gibson, T. J., CLUSTAL W: Improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice (1994) Nucleic Acids Res, 22 (22), pp. 4673-4680
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8 (1): 52-56, 29Bowie, J. U., Luthy, R., Eisenberg, D., A method to identify protein sequences that fold into a known three-dimensional structure (1991) Science, 253 (5016), pp. 164-170
Gabb, H. A., Jackson, R. M., Sternberg, M. J., Modelling protein docking using shape complementarity, electrostatics and biochemical information (1997) J. Mol. Biol, 272 (1), pp. 106-120
Jackson, R. M., Gabb, H. A., Sternberg, M. J., Rapid refinement of protein interfaces incorporating solvation: Application to the docking problem (1998) J. Mol. Biol, 276 (1), pp. 265-285
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Foley, S. F., van Vlijmen, H. W., Boynton, R. E., Adkins, H. B., Cheung, A. E., Singh, J., Sanicola, M., Wen, D., The CRIPTO/FRL-1/CRYPTIC (CFC) domain of human Cripto. Functional and structural insights through disulfide structure analysis (2003) Eur. J. Biochem, 270 (17), pp. 3610-3618
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Innis, C. A., Shi, J., Blundell, T. L., Evolutionary trace analysis of TGF-beta and related growth factors: Implications for site-directed mutagenesis (2000) Protein Eng, 13 (12), pp. 839-847
Sternberg, M. J., Gabb, H. A., Jackson, R. M., Moont, G., Protein-protein docking. Generation and filtering of complexes (2000) Methods Mol. Biol, 143, pp. 399-415
Structural insights into the interaction between the Cripto CFC domain and the ALK4 receptor
The protein Cripto is the founding member of the extra-cellular EGF-CFC growth factors, which are composed of two adjacent cysteine-rich domains: the EGF-like and the CFC. Members of the EGF-CFC family play key roles in embryonic development and are also implicated in tumourigenesis. Cripto is highly over-expressed in many tumours, while it is poorly detectable in normal tissues. Although both Cripto domains are involved in its tumourigenic activity, the CFC domain appears to play a crucial role. Indeed, through this domain, Cripto interferes with the onco-suppressive activity of Activins, either by blocking the Activin receptor ALK4 or by antagonising proteins of the TGF-beta family. We have undertaken the chemical synthesis and the structural characterisation of human CFC Cripto domain. Using a combined NMR and computational approach, supported by binding studies by SPR, we have investigated the molecular basis of the interaction between h-CFC and ALK4. Binding studies indicate that the synthetic h-CFC interacts with the ALK4 receptor with a K(D) in micro M range, whereas it does not recognise the ActRIIB receptor. The NMR study shows that the h-CFC overall topology is determined by the presence of three disulfide bridges and that residues H120 and W124 are located between the first strand and the first loop with the side chains externally exposed. A model of the CFC-ALK4 complex has also been obtained by molecular docking and shows that all residues indicated by prior mutagenesis studies can contribute to the ALK4-CFC interaction at the protein-protein interface.
The protein Cripto is the founding member of the extra-cellular EGF-CFC growth factors, which are composed of two adjacent cysteine-rich domains: the EGF-like and the CFC. Members of the EGF-CFC family play key roles in embryonic development and are also implicated in tumourigenesis. Cripto is highly over-expressed in many tumours, while it is poorly detectable in normal tissues. Although both Cripto domains are involved in its tumourigenic activity, the CFC domain appears to play a crucial role. Indeed, through this domain, Cripto interferes with the onco-suppressive activity of Activins, either by blocking the Activin receptor ALK4 or by antagonising proteins of the TGF-beta family. We have undertaken the chemical synthesis and the structural characterisation of human CFC Cripto domain. Using a combined NMR and computational approach, supported by binding studies by SPR, we have investigated the molecular basis of the interaction between h-CFC and ALK4. Binding studies indicate that the synthetic h-CFC interacts with the ALK4 receptor with a K(D) in micro M range, whereas it does not recognise the ActRIIB receptor. The NMR study shows that the h-CFC overall topology is determined by the presence of three disulfide bridges and that residues H120 and W124 are located between the first strand and the first loop with the side chains externally exposed. A model of the CFC-ALK4 complex has also been obtained by molecular docking and shows that all residues indicated by prior mutagenesis studies can contribute to the ALK4-CFC interaction at the protein-protein interface.
Structural insights into the interaction between the Cripto CFC domain and the ALK4 receptor
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Structural insights into the interaction between the Cripto CFC domain and the ALK4 receptor
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Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 2008 Aug 15; 14(16): 5209-5219.
Impact Factor: 6.488
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Del Vecchio S, Zannetti A, Fonti R, Pace L, Salvatore M
* Nuclear imaging in cancer theranostics (616 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2007 Jun; 51(2): 152-163.
Impact Factor: 1.724
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Palmieri G, Marino M, Salvatore M, Budillon A, Meo G, Caraglia M, Montella L
* Cetuximab is an active treatment of metastatic and chemorefractory thymoma (372 views)
Frontiers In Bioscience (ISSN: 1093-9946, 1093-4715), 2007 Jan 1; 12(2): 757-761.
Impact Factor: 2.989
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Di Gaetano S, Guglielmi F, Arciello A, Mangione P, Monti M, Pagnozzi D, Raimondi S, Giorgetti S, Orru S, Canale C, Pucci P, Dobson CM, Bellotti V, Piccoli R
* Recombinant amyloidogenic domain of ApoA-I: analysis of its fibrillogenic potential (365 views)
Biochemical And Biophysical Research Communications (ISSN: 0006-291x, 0006-291xprint), 2006 Dec 8; 351(1): 223-228.
Impact Factor: 2.855
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Calvanese L, Saporito A, Marasco D, D'Auria G, Minchiotti G, Pedone C, Paolillo L, Falcigno L, Ruvo M
* Solution structure of mouse Cripto CFC domain and its inactive variant Trp107Ala (429 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2006 Nov 30; 49(24): 7054-7062.
Impact Factor: 5.115
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Marasco D, Saporito A, Ponticelli S, Chambery A, De Falco S, Pedone C, Minchiotti G, Ruvo M
* Chemical synthesis of mouse Cripto CFC variants (363 views)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2006 Sep 15; 64(3): 779-788.
Impact Factor: 3.73
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Vacatello M, D'Auria G, Falcigno L, Dettin M, Gambaretto R, Di Bello C, Paolillo L
* Conformational Analysis Of Novel Heparin Binding Peptides (618 views)
Biomaterials (ISSN: 0142-9612, 1878-5905electronic, 0142-9612linking), 2005 Jun; 26(16): 3207-3214.
Impact Factor: 4.698
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Saviano M, Isernia C, Bassarello C, Di Lello P, Galdiero S, Mierke DF, Benedetti E, Pedone C
* Conformational analysis by NMR and distance geometry techniques of a peptide mimetic of the third helix of the Antennapedia homeodomain (436 views)
J Pept Res (ISSN: 1397-002x), 2005 Feb; 65(2): 200-208.
Impact Factor: 1.741
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Peggion C, Formaggio F, Crisma M, Toniolo C, Jimenez AI, Cativiela C, Kaptein B, Broxterman QB, Saviano M, Benedetti E
* Folding of peptides characterized by c3Val, a highly constrained analogue of valine (413 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2003; 68(2): 178-191.
Impact Factor: 2.733
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Langella E, Rega N, Improta R, Crescenzi O, Barone V
* Conformational analysis of the tyrosine dipeptide analogue in the gas phase and in aqueous solution by a density functional/continuum solvent model (292 views)
J Comput Chem (ISSN: 0192-8651, 1096-987xelectronic), 2002 Apr 30; 23(6): 650-661.
Impact Factor: 2.931
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Caraglia M, Tagliaferri P, Correale P, Genua G, Pinto A, Del Vecchio S, Esposito G, Bianco AR
CYTOSINE-ARABINOSIDE INCREASES THE BINDING OF I-125 LABELED EPIDERMAL GROWTH-FACTOR AND I-125 TRANSFERRIN AND ENHANCES THE IN-VITRO TARGETING OF HUMAN TUMOR-CELLS WITH ANTI-(GROWTH FACTOR-RECEPTOR) MAB (327 views)
Cancer Immunol Immunother (ISSN: 0340-7004, 0340-7004linking), 1993 Sep; 37(3): 150-156.
Impact Factor: 1.269
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Caraglia M, Tagliaferri P, Correale P, Genua G, Pinto A, Del Vecchio S, Esposito G, Bianco AR
Cytosine arabinoside increases the binding of 125I-labelled epidermal growth factor and 125I-transferrin and enhances the in vitro targeting of human tumour cells with anti-(growth factor receptor) mAb (236 views)
Cancer Immunol Immunother (ISSN: 0340-7004linking), 1993 Aug; 37 (3 ): 150-156.
Impact Factor: 4.293
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Zanotti G, Maione A, Rossi F, Saviano M, Pedone C, Tancredi T
BIOACTIVE PEPTIDES - CONFORMATIONAL STUDY OF A CYSTINYL CYCLOHEPTAPEPTIDE IN ITS FREE AND CALCIUM COMPLEXED FORMS (581 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1993 Jul; 33(7): 1083-1091.
Impact Factor: 2.425
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* NMR spectroscopy in the conformational analysis of peptides: an overview (91 views)
Curr Med Chem (ISSN: 0929-8673linking, 1875-533xelectronic), 2021; 28(14): 2729-2782.
Impact Factor: 4.184
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Foca G, Iaccarino E, Foca A, Sanguigno L, Untiveros G, Cuevas-nunez M, Strizzi L, Leonardi A, Ruvo M, Sandomenico A
* Development of conformational antibodies targeting Cripto-1 with neutralizing effects in vitro (535 views)
Biochimie (ISSN: 0300-9084linking, 1638-6183electronic), 2019 Mar; 158: 246-256.
Impact Factor: 3.787
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Mercurio FA, Marasco D, Di Natale C, Pirone L, Costantini S, Pedone EM, Leone M
* Targeting EphA2-Sam and Its Interactome: Design and Evaluation of Helical Peptides Enriched in Charged Residues (416 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-4227linking), 2016 Nov 17; 17(22): 2179-2188.
Impact Factor: 2.847
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De Rosa V, Iommelli F, Monti M, Fonti R, Votta G, Stoppelli MP, Del Vecchio S
* Reversal of Warburg Effect and Reactivation of Oxidative Phosphorylation by Differential Inhibition of EGFR Signaling Pathways in Non-Small Cell Lung Cancer (653 views)
Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 2015 Nov 15; 21(22): 5110-5120.
Impact Factor: 8.738
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Calce E, Monfregola L, Saviano M, De Luca S
* HER2-mediated anticancer drug delivery: strategies to prepare targeting ligands highly specific for the receptor (571 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2015 May 20; 22(21): 2525-2538.
Impact Factor: 3.455
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Mercurio FA, Di Natale C, Pirone L, Scognamiglio PL, Marasco D, Pedone EM, Saviano M, Leone M
* Peptide Fragments of Odin-Sam1: Conformational Analysis and Interaction Studies with EphA2-Sam (463 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-4227linking), 2015; 16(11): 1629-1636.
Impact Factor: 2.85
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Perri F, Pacelli R, Della Vittoria Scarpati G, Cella L, Giuliano M, Caponigro F, Pepe S
* Radioresistance in head and neck squamous cell carcinoma: Biological bases and therapeutic implications (522 views)
Head Neck-J Sci Spec (ISSN: 1043-3074), 2015; 37(5): 763-770.
Impact Factor: 2.76
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Iommelli F, De Rosa V, Gargiulo S, Panico M, Monti M, Greco A, Gramanzini M, Ortosecco G, Fonti R, Brunetti A, Del Vecchio S
* Monitoring Reversal of MET-Mediated Resistance to EGFR Tyrosine Kinase Inhibitors in Non-Small Cell Lung Cancer Using 3 '-Deoxy-3 '-[F-18]-Fluorothymidine Positron Emission Tomography (513 views)
Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 2014 Sep 15; 20(18): 4806-4815.
Impact Factor: 8.722
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Calce E, Sandomenico A, Saviano M, Ruvo M, De Luca S
* Cysteine Co-Oxidation Process Driven By Native Peptide Folding: An Example On Her2 Receptor Model System (366 views)
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2014; 46(5): 1197-1206.
Impact Factor: 3.293
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Formisano L, Nappi L, Rosa R, Marciano R, D'Amato C, D'Amato V, Damiano V, Raimondo L, Iommelli F, Scorziello A, Troncone G, Veneziani BM, Parsons SJ, De Placido S, Bianco R
* Epidermal growth factor-receptor activation modulates Src-dependent resistance to lapatinib in breast cancer models (458 views)
Breast Cancer Res Biomed Central Ltd (ISSN: 1465-5411), 2014; 16(3): R45-R45.
Impact Factor: 0.635
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Calce E, Monfregola L, Sandomenico A, Saviano M, De Luca S
* Fluorescence study for selecting specific ligands toward HER2 receptor: An example of receptor fragment approach (438 views)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 1768-3254electronic), 2013 Mar; 61: 116-121.
Impact Factor: 3.432
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Carotenuto A, Cipolletta E, Gomez-Monterrey I, Sala M, Vernieri E, Limatola A, Bertamino A, Musella S, Sorriento D, Grieco P, Trimarco B, Novellino E, Iaccarino G, Campiglia P
* Design, synthesis and efficacy of novel G protein-coupled receptor kinase 2 inhibitors (511 views)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 1768-3254electronic), 2013; 69: 384-392.
Impact Factor: 3.432
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Pedicini P, Nappi A, Strigari L, Jereczek-Fossa BA, Alterio D, Cremonesi M, Botta F, Vischioni B, Caivano R, Fiorentino A, Improta G, Storto G, Benassi M, Orecchia R, Salvatore M
* Correlation between EGFr expression and accelerated proliferation during radiotherapy of head and neck squamous cell carcinoma (488 views)
Radiation Oncology (ISSN: 1748-717x), 2012 Sep 24; 7: 143-143.
Impact Factor: 2.107
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Ziaco B, Diana D, Capasso D, Palumbo R, Celentano V, Di Stasi R, Fattorusso R, D'Andrea LD
* C-terminal truncation of Vascular Endothelial Growth Factor mimetic helical peptide preserves structural and receptor binding properties (367 views)
Biochem Biophys Res Commun (ISSN: 0006-291x), 2012 Jul 27; 424(2): 290-294.
Impact Factor: 2.406
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Riccio A, Cubellis MV
* Gain of function in CDKN1C (503 views)
Nature Genetics (ISSN: 1061-4036), 2012 Jul; 44(7): 737-738.
Impact Factor: 35.209
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Pedicini P, Caivano R, Jereczek-Fossa BA, Strigari L, Vischioni B, Alterio D, Cremonesi M, Botta F, Nappi A, Improta G, Storto G, Benassi M, Orecchia R
* Modelling the correlation between EGFr expression and tumour cell radiosensitivity, and combined treatments of radiation and monoclonal antibody EGFr inhibitors (382 views)
Theor Biol Med Model (ISSN: 1742-4682), 2012 Jun 19; 9(1): 23-23.
Impact Factor: 1.461
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Avitabile C, Moggio L, Malgieri G, Capasso D, Di Gaetano S, Saviano M, Pedone C, Romanelli A
* Gamma Sulphate Pna (pna S): Highly Selective Dna Binding Molecule Showing Promising Antigene Activity (448 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2012 May 7; 7(5): e35774-e35774.
Impact Factor: 3.73
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Zannetti A, Iommelli F, Speranza A, Salvatore M, Del Vecchio S
* 3'-deoxy-3'-18F-fluorothymidine (FLT) PET/CT to guide therapy with epidermal growth factor receptor (EGFR) antagonists and Bcl-xL inhibitors in non-small cell lung cancer (614 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 2012 Mar 1; 53(3): 443-450.
Impact Factor: 5.774
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Zannetti A, Iommelli F, Speranza A, Salvatore M, Del Vecchio S
* 3'-deoxy-3'-18F-fluorothymidine PET/CT to guide therapy with epidermal growth factor receptor antagonists and Bcl-xL inhibitors in non-small cell lung cancer (525 views)
J Nucl Med (ISSN: 1535-5667, 0161-5505, 1535-5667electronic), 2012 Mar 1; 53(3): 443-450.
Impact Factor: 5.774
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Folgiero V, Di Carlo SE, Bossi G, Spugnini E, Di Benedetto A, Bon G, Milella M, Fabi A, Accardo A, Morelli G, Mottolese M, Falcioni R
* Inhibition of p85, the non-catalytic subunit of phosphatidylinositol 3-kinase, exerts potent antitumor activity in human breast cancer cells (516 views)
Cell Death & (ISSN: 2041-4889, 2041-4889electronic), 2012; 3(12): N/D-N/D.
Impact Factor: 6.044
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Diana D, Basile A, De Rosa L, Di Stasi R, Auriemma S, Arra C, Pedone C, Turco MC, Fattorusso R, D'Andrea LD
* Beta-Hairpin Peptide That Targets Vascular Endothelial Growth Factor (vegf) Receptors: Design, Nmr Characterization, And Biological Activity (620 views)
Jbc Papers (ISSN: 1083-351x, 0021-9258, 0021-9258linking), 2011 Dec 2; 286(48): 41680-41691.
Impact Factor: 4.773
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Troise F, Monti M, Merlino A, Cozzolino F, Fedele C, Russo Krauss I, Sica F, Pucci P, D'Alessio G, De Lorenzo C
* A novel ErbB2 epitope targeted by human antitumor immunoagents (391 views)
Febs Journal (ISSN: 1742-464x), 2011 Apr; 278(7): 1156-1166.
Impact Factor: 3.79
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Calvanese L, Marasco D, Doti N, Saporito A, D'Auria G, Paolillo L, Ruvo M, Falcigno L
* Structural Investigations on the Nodal-Cripto Binding: A Theoretical and Experimental Approach (562 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2010 Nov; 93(11): 1011-1021.
Impact Factor: 2.572
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Lonardo E, Parish CL, Ponticelli S, Marasco D, Ribeiro D, Ruvo M, De Falco S, Arenas E, Minchiotti G
* A Small Synthetic Cripto Blocking Peptide Improves Neural Induction, Dopaminergic Differentiation, and Functional Integration of Mouse Embryonic Stem Cells in a Rat Model of Parkinson's Disease (771 views)
Stem Cells (ISSN: 1066-5099), 2010 Sep; 28(8): 1326-1337.
Impact Factor: 7.871
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Del Vecchio S, Zannetti A, Fonti R, Iommelli F, Pizzuti LM, Lettieri A, Salvatore M
* PET/CT in cancer research: From preclinical to clinical applications (617 views)
Contrast Media Mol Imaging (ISSN: 1555-4309, 1555-4309linking), 2010 Jul; 5(4): 190-200.
Impact Factor: 4.02
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Kaczmarek K, Farina B, Zubrzak P, Jankowski S, Zimecki M, Suder P, Benedetti E, Fattorusso R, Saviano M, Zabrocki J
* Synthesis, conformational analysis and immunological activity of β3Phe-substituted Cyclolinopeptide A analogues (460 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 166-174.
Impact Factor: 1.807
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Merlino A, Vergara A, Sica F, Mazzarella L
* The bis-histidyl complex in hemoproteins: A detailed conformational analysis of database protein structures and the case of Antarctic fish hemoglobins (331 views)
Marine Genomics (ISSN: 1874-7787), 2009 Mar; 2(1): 51-56.
Impact Factor: 1.2
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Insabato L, Amelio I, Quarto M, Zannetti A, Tolino F, De Mauro G, Cerchia L, Riccio P, Baumhoer D, Condorelli G, Terracciano L, De Franciscis V
* Elevated Expression of the Tyrosine Phosphatase SHP-1 Defines a Subset of High-Grade Breast Tumors (448 views)
Oncology (ISSN: 0030-2414), 2009; 77(6): 378-384.
Impact Factor: 2.112
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Chambery A, Vissers JPC, Langridge JI, Lonardo E, Minchiotti G, Ruvo M, Parente A
* Qualitative and quantitative proteomic profiling of cripto-1- embryonic stem cells by means of accurate mass LC-MS analysis (970 views)
J Proteome Res (ISSN: 1535-3893), 2009; 8(2): 1047-1058.
Impact Factor: 5.132
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Zannetti A, Iommelli F, Fonti R, Papaccioli A, Sommella J, Lettieri A, Pirozzi G, Bianco R, Tortora G, Salvatore M, Del Vecchio S
* Gefitinib induction of in vivo detectable signals by Bcl-2/Bcl-xL modulation of inositol trisphosphate receptor type (537 views)
Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 2008 Aug 15; 14(16): 5209-5219.
Impact Factor: 6.488
View Export to BibTeX Export to EndNote
Del Vecchio S, Zannetti A, Fonti R, Pace L, Salvatore M
* Nuclear imaging in cancer theranostics (616 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2007 Jun; 51(2): 152-163.
Impact Factor: 1.724
View Export to BibTeX Export to EndNote
Palmieri G, Marino M, Salvatore M, Budillon A, Meo G, Caraglia M, Montella L
* Cetuximab is an active treatment of metastatic and chemorefractory thymoma (372 views)
Frontiers In Bioscience (ISSN: 1093-9946, 1093-4715), 2007 Jan 1; 12(2): 757-761.
Impact Factor: 2.989
View Export to BibTeX Export to EndNote
Di Gaetano S, Guglielmi F, Arciello A, Mangione P, Monti M, Pagnozzi D, Raimondi S, Giorgetti S, Orru S, Canale C, Pucci P, Dobson CM, Bellotti V, Piccoli R
* Recombinant amyloidogenic domain of ApoA-I: analysis of its fibrillogenic potential (365 views)
Biochemical And Biophysical Research Communications (ISSN: 0006-291x, 0006-291xprint), 2006 Dec 8; 351(1): 223-228.
Impact Factor: 2.855
View Export to BibTeX Export to EndNote
Calvanese L, Saporito A, Marasco D, D'Auria G, Minchiotti G, Pedone C, Paolillo L, Falcigno L, Ruvo M
* Solution structure of mouse Cripto CFC domain and its inactive variant Trp107Ala (429 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2006 Nov 30; 49(24): 7054-7062.
Impact Factor: 5.115
View Export to BibTeX Export to EndNote
Marasco D, Saporito A, Ponticelli S, Chambery A, De Falco S, Pedone C, Minchiotti G, Ruvo M
* Chemical synthesis of mouse Cripto CFC variants (363 views)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2006 Sep 15; 64(3): 779-788.
Impact Factor: 3.73
View Export to BibTeX Export to EndNote
Vacatello M, D'Auria G, Falcigno L, Dettin M, Gambaretto R, Di Bello C, Paolillo L
* Conformational Analysis Of Novel Heparin Binding Peptides (618 views)
Biomaterials (ISSN: 0142-9612, 1878-5905electronic, 0142-9612linking), 2005 Jun; 26(16): 3207-3214.
Impact Factor: 4.698
View Export to BibTeX Export to EndNote
Saviano M, Isernia C, Bassarello C, Di Lello P, Galdiero S, Mierke DF, Benedetti E, Pedone C
* Conformational analysis by NMR and distance geometry techniques of a peptide mimetic of the third helix of the Antennapedia homeodomain (436 views)
J Pept Res (ISSN: 1397-002x), 2005 Feb; 65(2): 200-208.
Impact Factor: 1.741
View Export to BibTeX Export to EndNote
Peggion C, Formaggio F, Crisma M, Toniolo C, Jimenez AI, Cativiela C, Kaptein B, Broxterman QB, Saviano M, Benedetti E
* Folding of peptides characterized by c3Val, a highly constrained analogue of valine (413 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2003; 68(2): 178-191.
Impact Factor: 2.733
View Export to BibTeX Export to EndNote
Langella E, Rega N, Improta R, Crescenzi O, Barone V
* Conformational analysis of the tyrosine dipeptide analogue in the gas phase and in aqueous solution by a density functional/continuum solvent model (292 views)
J Comput Chem (ISSN: 0192-8651, 1096-987xelectronic), 2002 Apr 30; 23(6): 650-661.
Impact Factor: 2.931
View Export to BibTeX Export to EndNote
Caraglia M, Tagliaferri P, Correale P, Genua G, Pinto A, Del Vecchio S, Esposito G, Bianco AR
CYTOSINE-ARABINOSIDE INCREASES THE BINDING OF I-125 LABELED EPIDERMAL GROWTH-FACTOR AND I-125 TRANSFERRIN AND ENHANCES THE IN-VITRO TARGETING OF HUMAN TUMOR-CELLS WITH ANTI-(GROWTH FACTOR-RECEPTOR) MAB (327 views)
Cancer Immunol Immunother (ISSN: 0340-7004, 0340-7004linking), 1993 Sep; 37(3): 150-156.
Impact Factor: 1.269
View Export to BibTeX Export to EndNote
Caraglia M, Tagliaferri P, Correale P, Genua G, Pinto A, Del Vecchio S, Esposito G, Bianco AR
Cytosine arabinoside increases the binding of 125I-labelled epidermal growth factor and 125I-transferrin and enhances the in vitro targeting of human tumour cells with anti-(growth factor receptor) mAb (236 views)
Cancer Immunol Immunother (ISSN: 0340-7004linking), 1993 Aug; 37 (3 ): 150-156.
Impact Factor: 4.293
View Export to BibTeX Export to EndNote
Zanotti G, Maione A, Rossi F, Saviano M, Pedone C, Tancredi T
BIOACTIVE PEPTIDES - CONFORMATIONAL STUDY OF A CYSTINYL CYCLOHEPTAPEPTIDE IN ITS FREE AND CALCIUM COMPLEXED FORMS (581 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1993 Jul; 33(7): 1083-1091.
Impact Factor: 2.425
View Export to BibTeX Export to EndNote
42 Records (37 excluding Abstracts).
Total impact factor: 186.908 (172.931 excluding Abstracts).
Total 5 year impact factor: 199.06 (183.99 excluding Abstracts).
Total impact factor: 186.908 (172.931 excluding Abstracts).
Total 5 year impact factor: 199.06 (183.99 excluding Abstracts).
456 views. Last view on Sunday 19 March 2023, 6:57:37
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