Supramolecular aggregates containing lipophilic Gd(III) complexes as contrast agents in MRI (591 views)
Coord Chem Rev (ISSN: 0010-8545), 2009 Sep; 253(17-18): 2193-2213.
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Paper type: Journal Article,
Impact factor: 11.225, 5-year impact factor: 12.752
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Keywords: Amphiphilic Gadolinium Complexes, Liposomes, Micelles, Mri Contrast Agents, Target-Selective Contrast Agents,
Affiliations:
*** IBB - CNR ***
Department of Biological Sciences, CIRPeB University of Naples Federico II, IBB CNR, Via Mezzocannone 16, 80134 Naples, Italy
Area Funzionale di Medicina Nucleare, Istituto Nazionale Tumori, Fondazione G. Pascale, Via M. Semola, 80131 Naples, Italy
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Coord Chem Rev (ISSN: 0010-8545), 2009 Sep; 253(17-18): 2193-2213.
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Paper type: Journal Article,
Impact factor: 11.225, 5-year impact factor: 12.752
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-67649382710&partnerID=40&md5=5a6a86e41d6512f7693cd9a549c66b24
Keywords: Amphiphilic Gadolinium Complexes, Liposomes, Micelles, Mri Contrast Agents, Target-Selective Contrast Agents,
Affiliations:
*** IBB - CNR ***
Department of Biological Sciences, CIRPeB University of Naples Federico II, IBB CNR, Via Mezzocannone 16, 80134 Naples, Italy
Area Funzionale di Medicina Nucleare, Istituto Nazionale Tumori, Fondazione G. Pascale, Via M. Semola, 80131 Naples, Italy
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Supramolecular aggregates containing lipophilic Gd(III) complexes as contrast agents in MRI
Magnetic resonance imaging (MRI) contrast agents based on paramagnetic gadolinium complexes are widely used in biomedical research and diagnosis. Their application is intended to improve efficacy of MRI providing physiological information along with the impressive anatomical detail already obtained by images without contrast. The classical gadolinium complexes currently used for MRI contrast enhancement are all low molecular weight compounds that rapidly equilibrate between the intra and extravascular spaces after intravenous administration. In order to obtain gadolinium-based agents with different pharmacokinetic properties, supramolecular aggregates such as micelles and liposomes have been recently proposed. Micelles and liposomes, obtained by the aggregation of lipophilic gadolinium complexes are here described, with the aim to correlate their structural and relaxometric properties. We report on the state of the art in the development of supramolecular aggregates obtained by self-assembly of lipophilic gadolinium complexes and aggregates in which lipophilic gadolinium complexes are assembled with surfactants. Moreover aggregates derivatized with bioactive molecules, such as peptides and antibodies, acting as target selective MRI contrast agents are described. © 2009 Elsevier B.V. All rights reserved.
Magnetic resonance imaging (MRI) contrast agents based on paramagnetic gadolinium complexes are widely used in biomedical research and diagnosis. Their application is intended to improve efficacy of MRI providing physiological information along with the impressive anatomical detail already obtained by images without contrast. The classical gadolinium complexes currently used for MRI contrast enhancement are all low molecular weight compounds that rapidly equilibrate between the intra and extravascular spaces after intravenous administration. In order to obtain gadolinium-based agents with different pharmacokinetic properties, supramolecular aggregates such as micelles and liposomes have been recently proposed. Micelles and liposomes, obtained by the aggregation of lipophilic gadolinium complexes are here described, with the aim to correlate their structural and relaxometric properties. We report on the state of the art in the development of supramolecular aggregates obtained by self-assembly of lipophilic gadolinium complexes and aggregates in which lipophilic gadolinium complexes are assembled with surfactants. Moreover aggregates derivatized with bioactive molecules, such as peptides and antibodies, acting as target selective MRI contrast agents are described. © 2009 Elsevier B.V. All rights reserved.
Supramolecular aggregates containing lipophilic Gd(III) complexes as contrast agents in MRI
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Supramolecular aggregates containing lipophilic Gd(III) complexes as contrast agents in MRI
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Longo DL, Carella A, Corrado A, Pirotta E, Mohanta Z, Singh A, Stabinska J, Liu G, Mcmahon MT
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Baroni S, Stefania R, Broche LM, Senn N, Lurie DJ, Ross PJ, Aime S, Geninatti Crich S
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Tear LR, Carrera C, Gianolio E, Aime S
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Accardo A, Gianolio E, Arena F, Barnert S, Schubert R, Tesauro D, Morelli G
* Nanostructures based on monoolein or diolein and amphiphilic gadolinium complexes as MRI contrast agents (412 views)
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Accardo A, Morisco A, Gianolio E, Tesauro D, Mangiapia G, Radulescu A, Brandt A, Morelli G
* Nanoparticles containing octreotide peptides and gadolinium complexes for MRI applications (504 views)
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Accardo A, Tesauro D, Morisco A, Mangiapia G, Vaccaro M, Gianolio E, Heenan RK, Paduano L, Morelli G
* Micelles obtained by aggregation of gemini surfactants containing the CCK8 peptide and a gadolinium complex (398 views)
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Morisco A, Accardo A, Gianolio E, Tesauro D, Benedetti E, Morelli G
* Micelles derivatized with octreotide as potential target-selective contrast agents in MRI (417 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 242-250.
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Tesauro D, Accardo A, Gianolio E, Paduano L, Teixeira J, Schillén K, Aime S, Morelli G
* Peptide derivatized lamellar aggregates as target-specific MRI contrast agents (580 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2007 May 25; 8(8): 950-955.
Impact Factor: 3.446
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Vaccaro M, Accardo A, Tesauro D, Mangiapia G, Loef D, Schillen K, Soederman O, Morelli G, Paduan L
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Morelli G, Accardo A, Tesauro D, Pedone C, Mangiapia G, Paduano L, Gianolio E
* Multicomponent aggregates containing the CCK8 bioactive peptide and Gd complexes as target-specific MRI contrast agents (279 views)
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Impact Factor: 0
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* A snapshot of the vast array of diamagnetic CEST MRI contrast agents (6 views)
Nmr Biomed (ISSN: 0952-3480linking), 2022 Feb 20; N/D: e4715-N/D.
Impact Factor: 4.044
View Export to BibTeX Export to EndNote
Baroni S, Stefania R, Broche LM, Senn N, Lurie DJ, Ross PJ, Aime S, Geninatti Crich S
* A Novel Class of (1) H-MRI Contrast Agents Based on the Relaxation Enhancement Induced on Water Protons by (14) N-Containing Imidazole Moieties (74 views)
Angew Chem Int Ed (ISSN: 1433-7851linking, 1521-3773electronic), 2021 Feb 19; 60(8): 4208-4214.
Impact Factor: 12.959
View Export to BibTeX Export to EndNote
Tear LR, Carrera C, Gianolio E, Aime S
* Towards an Improved Design of MRI Contrast Agents: Synthesis and Relaxometric Characterisation of Gd-HPDO3A Analogues (73 views)
Chemistry (ISSN: 0947-6539linking, 1521-3765electronic), 2020 May 12; 26(27): 6056-6063.
Impact Factor: 4.857
View Export to BibTeX Export to EndNote
Accardo A, Gianolio E, Arena F, Barnert S, Schubert R, Tesauro D, Morelli G
* Nanostructures based on monoolein or diolein and amphiphilic gadolinium complexes as MRI contrast agents (412 views)
J Mater Chem B (ISSN: 2050-7518, 2050-750x), 2013; 1(5): 617-628.
Impact Factor: 8.535
View Export to BibTeX Export to EndNote
Accardo A, Morisco A, Gianolio E, Tesauro D, Mangiapia G, Radulescu A, Brandt A, Morelli G
* Nanoparticles containing octreotide peptides and gadolinium complexes for MRI applications (504 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2011 Feb; 17(2): 154-162.
Impact Factor: 1.799
View Export to BibTeX Export to EndNote
Accardo A, Tesauro D, Morisco A, Mangiapia G, Vaccaro M, Gianolio E, Heenan RK, Paduano L, Morelli G
* Micelles obtained by aggregation of gemini surfactants containing the CCK8 peptide and a gadolinium complex (398 views)
J Biol Inorg Chem (ISSN: 0949-8257, 1432-1327electronic, 0949-8257linking), 2009 May; 14(4): 587-599.
Impact Factor: 3.415
View Export to BibTeX Export to EndNote
Morisco A, Accardo A, Gianolio E, Tesauro D, Benedetti E, Morelli G
* Micelles derivatized with octreotide as potential target-selective contrast agents in MRI (417 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 242-250.
Impact Factor: 1.807
View Export to BibTeX Export to EndNote
Tesauro D, Accardo A, Gianolio E, Paduano L, Teixeira J, Schillén K, Aime S, Morelli G
* Peptide derivatized lamellar aggregates as target-specific MRI contrast agents (580 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2007 May 25; 8(8): 950-955.
Impact Factor: 3.446
View Export to BibTeX Export to EndNote
Vaccaro M, Accardo A, Tesauro D, Mangiapia G, Loef D, Schillen K, Soederman O, Morelli G, Paduan L
* Supramolecular aggregates of amphiphilic gadolinium complexes as blood pool MRI/MRA contrast agents: Physicochemical characterization (441 views)
Langmuir (ISSN: 0743-7463), 2006 Jul 18; 22(15): 6635-6643.
Impact Factor: 3.902
View Export to BibTeX Export to EndNote
Morelli G, Accardo A, Tesauro D, Pedone C, Mangiapia G, Paduano L, Gianolio E
* Multicomponent aggregates containing the CCK8 bioactive peptide and Gd complexes as target-specific MRI contrast agents (279 views)
Peptides 2004 Proceedings, 2005; N/D: N/D-N/D.
Impact Factor: 0
View Export to BibTeX Export to EndNote
10 Records (9 excluding Abstracts).
Total impact factor: 44.764 (44.764 excluding Abstracts).
Total 5 year impact factor: 43.692 (43.692 excluding Abstracts).
Total impact factor: 44.764 (44.764 excluding Abstracts).
Total 5 year impact factor: 43.692 (43.692 excluding Abstracts).
591 views. Last view on Tuesday 21 March 2023, 9:46:45
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