Synthesis, conformational analysis and immunological activity of β3Phe-substituted Cyclolinopeptide A analogues (460 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 166-174.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 1.807, 5-year impact factor: 1.872
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-63449086094&partnerID=40&md5=95ee425cb9b055450705d8b5d7537f73
Keywords: β3phe, Cla, Immunosuppressive Activity, Nmr Spectroscopy, Cyclolinopeptide A, Cyclolinopeptide A Derivative, Cyclopeptide, Cyclosporin, Freund Adjuvant, Interleukin 1, Isoleucine, Linseed Oil, Nonapeptide, Peptide Derivative, Phenylalanine, Proline, Tetrapeptide, Unclassified Drug, Valine, Amino Acid Sequence, Amino Acid Substitution, Animal Experiment, Cellular Immunity, Conference Paper, Controlled Study, Drug Mechanism, Female, Humoral Immunity, Hydrophobicity, Immunoreactivity, Molecular Interaction, Molecular Recognition, Mouse, Nonhuman, Nuclear Magnetic Resonance Spectroscopy, Peptide Synthesis, Priority Journal, Protein Conformation, Structure Analysis, Antibody Production, Article, Chemistry, Drug Effect, Immunology, Protein Secondary Structure, Antibody Formation, Protein Structure,
Affiliations:
*** IBB - CNR ***
Institute of Organic Chemistry, Faculty of Chemistry, Technical University of Łódź, Zeromskiego 116, 90-924 Łódź, Poland
Istituto di Biostrutture e Bioimmagini, CNR, Università degli Studi di Napoli Federico II, via Mezzocannone 16, 80134 Napoli, Italy
Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, R. Weigla 12, 53-114 Wroclaw, Poland
Dipartimento di Scienze Ambientali, Seconda Universitá di Napoli, via Vivaldi 43, 81100 Caserta, Italy
References:
Ellis, G.P., West, G.B., Cyclosporins, fungal metabolites with immunosuppressive activities (1998) Prog. Med. Chem, 25, pp. 1-3
Sigal NH, Dumont FJ. Cyclosporin A, FK-506 and rapamycin: pharmacological probes of lymphocyte signal transduction. Annu. Rev. Immunol. 1989
10: 519-560Prox, A., Weygand, F., Sequenzanalyse von peptiden durch kombination von gaschromatographie und massenspektrometrie (1967) Peptides, Proceedings 8th European Peptide Symposium, pp. 158-172. , Beyerman HC, van de Linde A, Maasen van den Brink W eds, North-Holland: Amsterdam
Kaufmann, H.P., Tobschirbel, A., Ueber ein oligopeptid aus leinsamen. (1959) Chem. Ber, 92, pp. 2805-2809
Wieczorek, Z., Bengtsson, B., Trojnar, J., Siemion, I.Z., Immunosuppressive activity of Cyclolinopeptide A (1991) Pept. Res, 4, pp. 275-283
Siemion, I.Z., Cebrat, M., Wieczorek, Z., Cyclolinopeptide and their analogs - a new family of peptide immunosuppressants affecting the calcineurin system (1999) Arch. Immunol. Ther. Exp, 47, pp. 143-153
Tancredi, T., Zanotti, G., Rossi, F., Benedetti, E., Pedone, C., Temussi, P.A., Comparison of the conformations of cyclolinopeptide A in the solid state and in solution (1989) Biopolymers, 28, pp. 513-523
Di Blasio, B., Rossi, F., Benedetti, E., Pavone, V., Pedone, C., Temussi, P., Zanotti, G., Tancredi, T., Bioactive peptides: Solid-state and solution conformation of cyclolinopeptide A (1989) J. Am. Chem. Soc, 111, pp. 9089-9098
Saviano, M., Aida, M., Corongiu, G., Molecular dynamics simulation in vacuo and in solution of cyclolinopeptide A: A conformational study (1991) Biopolymers, 31, pp. 1017-1024
Saviano, M., Rossi, F., Pavone, V., Di Blasio, B., Pedone, C., Molecular dynamics simulation in vacuo and in solution of [Aib5,6-D-Ala8] cyclolinopeptide A: A conformational and comparative study (1992) J. Biomol. Struct. Dyn, 9, pp. 1045-1060
Tancredi, T., Benedetti, E., Grimaldi, M., Pedone, C., Rossi, F., Saviano, M., Temussi, P.A., Zanotti, G., Ion binding of cyclolinopeptide A: An nmr and CD conformational study (1991) Biopolymers, 31, pp. 761-767
Zanotti, G., Maione, A., Rossi, F., Saviano, M., Pedone, C., Tancredi, T., Bioactive peptides: Conformational study of a cystinyl cycloheptapeptide in its free and calcium complexed forms (1993) Biopolymers, 33, pp. 1083-1091
Saviano, G., Rossi, F., Benedetti, E., Pedone, C., Mierke, D.F., Maione, A., Zanotti, G., Saviano, M., Structural consequences of metal complexation of cyclo[Pro-Phe-Phe-Ala-Xaa]2 decapeptides (2001) Chem. - Eur. J, 7, pp. 1176-1183
Siemion, I.Z., Pȩdyczak, A., Strug, I., Wieczorek, Z., Synthesis and biological studies on analogs of Cyclolinopeptide A with a shortened peptide chain (1994) Arch. Immunol. Ther. Exp, 42, pp. 459-465
Zubrzak, P., Leplawy, M.T., Kowalski, M.L., Szkudlińska, B., Paneth, P., Sillbering, J., Suder, P., Zabrocki, J., Correlating biological activity with calculated geometric motifs in cyclolinopeptide A analogs (2004) J. Phys. Org. Chem, 17, pp. 625-630
Seebach, D., Overhand, M., Kühnle, F.N.M., Martinoni, B., β-Peptides: Synthesis by Arndt-Eistert homologation with concomitant peptide coupling. Structure determination by NMR and CD spectroscopy and by X-ray crystallography. Helical secondary structure of a β-hexapeptide in solution and its stability towards pepsin (1996) Helv. Chim. Acta, 79, pp. 913-941
Shinagawa, S., Kanamaru, T., Harada, S., Asai, M., Okazaki, H., Chemistry of emeriamine and its analogs and their inhibitory activity in long-chain fatty acid oxidation (1987) J. Med. Chem, 30, pp. 1458-1463
Wang, S.S., Gisin, B.F., Winter, D.P., Makofske, R., Kulesha, I.D., Tzougraki, C., Meienhofer, J., Facile synthesis of amino acid and peptide esters under mild conditions via cesium salts (1977) J. Org. Chem, 42, pp. 1286-1290
Kaiser, E., Colescott, R., Bossinger, C.D., Cook, P., Color test for detection of free amino groups in the solid-phase synthesis of peptides (1970) Anal. Biochem, 34, pp. 595-598
Vojkovsky, T., Detection of secondary-amines on solid-phase (1995) Pept. Res, 8, pp. 236-237
Stewart, J.M., Solid Phase Peptide Synthesis (1984) Pierce Chem, , Corp, Rockfort, IL
Li, P., Roller, P.P., Cyclization strategies in peptide derived drug design (2002) Curr. Top. Med. Chem, 2, pp. 325-341
Davies, J.S., The cyclization of peptides and depsipeptides (2003) J. Pept. Sci, 9, pp. 471-501
Rance, M., Sørensen, O.W., Bodenhausen, G., Wagner, G., Ernst, R.R., Wüthrich, K., Improved spectral resolution in cosy 1H NMR spectra of proteins via double quantum filtering (1983) Biochem. Biophys. Res. Commun, 117, pp. 479-485
Braunschweiler, L., Ernst, R.R., Coherence transfer by isotropic mixing - application to proton correlation spectroscopy (1983) J. Magn. Reson, 53, pp. 521-528
Kumar, A., Ernst, R.R., Wüthrich, K., A two-dimensional nuclear Overhauser enhancement (2D NOE) experiment for the elucidation of complete proton-proton cross-relaxation networks in biological macromolecules (1980) Biochem. Biophys. Res. Commun, 95, pp. 1-6
Griesinger, C., Ernst, R.R., Frequency offset effects and their elimination in NMR rotating-frame cross-relaxation spectroscopy (1987) J. Magn. Reson, 75, pp. 261-271
Hwang, T.L., Shaka, A.J., Water suppression that works: Excitation sculpting using arbitrary wave-forms and pulsed-field gradients (1995) J. Magn. Reson., Ser. A, 112, pp. 275-279
Dalvit, C., Efficient multiple-solvent suppression for the study of the interactions of organic solvents with biomolecules (1998) J. Biomol. NMR, 11, pp. 437-444
Bartels, C., Xia, T., Billeter, M., Wüthrich, K., The program XEASY for computer-supported NMR spectral analysis of biological macromolecules (1995) J. Biomol. NMR, 5, pp. 1-10
Keller, R., (2004) The Computer Aided Resonance Assignment Tutorial, , ISBN 3-85600-112-3. CANTINA Verlag: Goldau
Güntert, P., Mumenthaler, C., Wüthrich, K., Torsion angle dynamics for NMR structure calculationwith the new program DYANA (1997) J. Mol. Biol, 273, pp. 283-298
Koradi, R., Billeter, M., Wüthrich, K., MOLMOL: A program for display and analysis of macromolecular structures (1996) J. Mol. Graphics, 14, pp. 51-55
Mishell, R.I., Dutton, R., Immunization of dissociated spleen cell cultures from normal mice (1967) J. Exp.Med, 126, pp. 426-443
Lagrange, P.H., Mackaness, G.B., Miller, T.E., Pardon, P., Influence of dose and route of antigen injection on the immunological induction of T cells (1974) J. Exp. Med, 139, pp. 528-542
Wüthrich, K., (1986) NMR of Proteins and Nucleic Acids, , Wiley-Interscience: New York
Berliner, L.J., Reuben, J., (1980) Biological Magnetic Resonance, 2, pp. 286-288. , Plenum Press: New York
Karle, I., Wieland, T., Fourth polymorph of [Phe4 Val6] antamanide (pentahydrate) (1987) Int. J. Pept. Protein Res, 29, pp. 596-603
Kessler, H., Bats, J.W., Lautz, J., Müller, A., Conformation of antamanide (1989) Liebigs Ann. Chem, pp. 913-928
PolS, D., Zorn, C., Klein, C.D., Zerbe, O., Reiser, O., Surprisingly stable helical conformations in α/β-peptides by incorporation of cis-β-aminocyclopropane carboxylic acids (2004) Angew. Chem., Int. Ed. Engl, 43, pp. 511-514
Zimmerman, S.S., Pottle, M.S., Nemethy, G., Scheraga, H.A., Conformational analysis of th 20 naturally occurring amino acid residues using ECEPP (1977) Macromolecules, 10, pp. 1-9
Zimecki, M., Wieczorek, Z., A biorhythm in the humoral immune response to SRBC in mice (1991) Arch. Immunol. Ther. Exp, 39, pp. 485-488
Ellis, G. P., West, G. B., Cyclosporins, fungal metabolites with immunosuppressive activities (1998) Prog. Med. Chem, 25, pp. 1-3
Kaufmann, H. P., Tobschirbel, A., Ueber ein oligopeptid aus leinsamen. (1959) Chem. Ber, 92, pp. 2805-2809
Siemion, I. Z., Cebrat, M., Wieczorek, Z., Cyclolinopeptide and their analogs - a new family of peptide immunosuppressants affecting the calcineurin system (1999) Arch. Immunol. Ther. Exp, 47, pp. 143-153
Siemion, I. Z., P dyczak, A., Strug, I., Wieczorek, Z., Synthesis and biological studies on analogs of Cyclolinopeptide A with a shortened peptide chain (1994) Arch. Immunol. Ther. Exp, 42, pp. 459-465
Wang, S. S., Gisin, B. F., Winter, D. P., Makofske, R., Kulesha, I. D., Tzougraki, C., Meienhofer, J., Facile synthesis of amino acid and peptide esters under mild conditions via cesium salts (1977) J. Org. Chem, 42, pp. 1286-1290
Stewart, J. M., Solid Phase Peptide Synthesis (1984) Pierce Chem, , Corp, Rockfort, IL
Li, P., Roller, P. P., Cyclization strategies in peptide derived drug design (2002) Curr. Top. Med. Chem, 2, pp. 325-341
Davies, J. S., The cyclization of peptides and depsipeptides (2003) J. Pept. Sci, 9, pp. 471-501
Rance, M., S rensen, O. W., Bodenhausen, G., Wagner, G., Ernst, R. R., W thrich, K., Improved spectral resolution in cosy 1H NMR spectra of proteins via double quantum filtering (1983) Biochem. Biophys. Res. Commun, 117, pp. 479-485
Hwang, T. L., Shaka, A. J., Water suppression that works: Excitation sculpting using arbitrary wave-forms and pulsed-field gradients (1995) J. Magn. Reson., Ser. A, 112, pp. 275-279
G ntert, P., Mumenthaler, C., W thrich, K., Torsion angle dynamics for NMR structure calculationwith the new program DYANA (1997) J. Mol. Biol, 273, pp. 283-298
Mishell, R. I., Dutton, R., Immunization of dissociated spleen cell cultures from normal mice (1967) J. Exp. Med, 126, pp. 426-443
Lagrange, P. H., Mackaness, G. B., Miller, T. E., Pardon, P., Influence of dose and route of antigen injection on the immunological induction of T cells (1974) J. Exp. Med, 139, pp. 528-542
W thrich, K., (1986) NMR of Proteins and Nucleic Acids, , Wiley-Interscience: New York
Berliner, L. J., Reuben, J., (1980) Biological Magnetic Resonance, 2, pp. 286-288. , Plenum Press: New York
Zimmerman, S. S., Pottle, M. S., Nemethy, G., Scheraga, H. A., Conformational analysis of th 20 naturally occurring amino acid residues using ECEPP (1977) Macromolecules, 10, pp. 1-9
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 166-174.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 1.807, 5-year impact factor: 1.872
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-63449086094&partnerID=40&md5=95ee425cb9b055450705d8b5d7537f73
Keywords: β3phe, Cla, Immunosuppressive Activity, Nmr Spectroscopy, Cyclolinopeptide A, Cyclolinopeptide A Derivative, Cyclopeptide, Cyclosporin, Freund Adjuvant, Interleukin 1, Isoleucine, Linseed Oil, Nonapeptide, Peptide Derivative, Phenylalanine, Proline, Tetrapeptide, Unclassified Drug, Valine, Amino Acid Sequence, Amino Acid Substitution, Animal Experiment, Cellular Immunity, Conference Paper, Controlled Study, Drug Mechanism, Female, Humoral Immunity, Hydrophobicity, Immunoreactivity, Molecular Interaction, Molecular Recognition, Mouse, Nonhuman, Nuclear Magnetic Resonance Spectroscopy, Peptide Synthesis, Priority Journal, Protein Conformation, Structure Analysis, Antibody Production, Article, Chemistry, Drug Effect, Immunology, Protein Secondary Structure, Antibody Formation, Protein Structure,
Affiliations:
*** IBB - CNR ***
Institute of Organic Chemistry, Faculty of Chemistry, Technical University of Łódź, Zeromskiego 116, 90-924 Łódź, Poland
Istituto di Biostrutture e Bioimmagini, CNR, Università degli Studi di Napoli Federico II, via Mezzocannone 16, 80134 Napoli, Italy
Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, R. Weigla 12, 53-114 Wroclaw, Poland
Dipartimento di Scienze Ambientali, Seconda Universitá di Napoli, via Vivaldi 43, 81100 Caserta, Italy
References:
Ellis, G.P., West, G.B., Cyclosporins, fungal metabolites with immunosuppressive activities (1998) Prog. Med. Chem, 25, pp. 1-3
Sigal NH, Dumont FJ. Cyclosporin A, FK-506 and rapamycin: pharmacological probes of lymphocyte signal transduction. Annu. Rev. Immunol. 1989
10: 519-560Prox, A., Weygand, F., Sequenzanalyse von peptiden durch kombination von gaschromatographie und massenspektrometrie (1967) Peptides, Proceedings 8th European Peptide Symposium, pp. 158-172. , Beyerman HC, van de Linde A, Maasen van den Brink W eds, North-Holland: Amsterdam
Kaufmann, H.P., Tobschirbel, A., Ueber ein oligopeptid aus leinsamen. (1959) Chem. Ber, 92, pp. 2805-2809
Wieczorek, Z., Bengtsson, B., Trojnar, J., Siemion, I.Z., Immunosuppressive activity of Cyclolinopeptide A (1991) Pept. Res, 4, pp. 275-283
Siemion, I.Z., Cebrat, M., Wieczorek, Z., Cyclolinopeptide and their analogs - a new family of peptide immunosuppressants affecting the calcineurin system (1999) Arch. Immunol. Ther. Exp, 47, pp. 143-153
Tancredi, T., Zanotti, G., Rossi, F., Benedetti, E., Pedone, C., Temussi, P.A., Comparison of the conformations of cyclolinopeptide A in the solid state and in solution (1989) Biopolymers, 28, pp. 513-523
Di Blasio, B., Rossi, F., Benedetti, E., Pavone, V., Pedone, C., Temussi, P., Zanotti, G., Tancredi, T., Bioactive peptides: Solid-state and solution conformation of cyclolinopeptide A (1989) J. Am. Chem. Soc, 111, pp. 9089-9098
Saviano, M., Aida, M., Corongiu, G., Molecular dynamics simulation in vacuo and in solution of cyclolinopeptide A: A conformational study (1991) Biopolymers, 31, pp. 1017-1024
Saviano, M., Rossi, F., Pavone, V., Di Blasio, B., Pedone, C., Molecular dynamics simulation in vacuo and in solution of [Aib5,6-D-Ala8] cyclolinopeptide A: A conformational and comparative study (1992) J. Biomol. Struct. Dyn, 9, pp. 1045-1060
Tancredi, T., Benedetti, E., Grimaldi, M., Pedone, C., Rossi, F., Saviano, M., Temussi, P.A., Zanotti, G., Ion binding of cyclolinopeptide A: An nmr and CD conformational study (1991) Biopolymers, 31, pp. 761-767
Zanotti, G., Maione, A., Rossi, F., Saviano, M., Pedone, C., Tancredi, T., Bioactive peptides: Conformational study of a cystinyl cycloheptapeptide in its free and calcium complexed forms (1993) Biopolymers, 33, pp. 1083-1091
Saviano, G., Rossi, F., Benedetti, E., Pedone, C., Mierke, D.F., Maione, A., Zanotti, G., Saviano, M., Structural consequences of metal complexation of cyclo[Pro-Phe-Phe-Ala-Xaa]2 decapeptides (2001) Chem. - Eur. J, 7, pp. 1176-1183
Siemion, I.Z., Pȩdyczak, A., Strug, I., Wieczorek, Z., Synthesis and biological studies on analogs of Cyclolinopeptide A with a shortened peptide chain (1994) Arch. Immunol. Ther. Exp, 42, pp. 459-465
Zubrzak, P., Leplawy, M.T., Kowalski, M.L., Szkudlińska, B., Paneth, P., Sillbering, J., Suder, P., Zabrocki, J., Correlating biological activity with calculated geometric motifs in cyclolinopeptide A analogs (2004) J. Phys. Org. Chem, 17, pp. 625-630
Seebach, D., Overhand, M., Kühnle, F.N.M., Martinoni, B., β-Peptides: Synthesis by Arndt-Eistert homologation with concomitant peptide coupling. Structure determination by NMR and CD spectroscopy and by X-ray crystallography. Helical secondary structure of a β-hexapeptide in solution and its stability towards pepsin (1996) Helv. Chim. Acta, 79, pp. 913-941
Shinagawa, S., Kanamaru, T., Harada, S., Asai, M., Okazaki, H., Chemistry of emeriamine and its analogs and their inhibitory activity in long-chain fatty acid oxidation (1987) J. Med. Chem, 30, pp. 1458-1463
Wang, S.S., Gisin, B.F., Winter, D.P., Makofske, R., Kulesha, I.D., Tzougraki, C., Meienhofer, J., Facile synthesis of amino acid and peptide esters under mild conditions via cesium salts (1977) J. Org. Chem, 42, pp. 1286-1290
Kaiser, E., Colescott, R., Bossinger, C.D., Cook, P., Color test for detection of free amino groups in the solid-phase synthesis of peptides (1970) Anal. Biochem, 34, pp. 595-598
Vojkovsky, T., Detection of secondary-amines on solid-phase (1995) Pept. Res, 8, pp. 236-237
Stewart, J.M., Solid Phase Peptide Synthesis (1984) Pierce Chem, , Corp, Rockfort, IL
Li, P., Roller, P.P., Cyclization strategies in peptide derived drug design (2002) Curr. Top. Med. Chem, 2, pp. 325-341
Davies, J.S., The cyclization of peptides and depsipeptides (2003) J. Pept. Sci, 9, pp. 471-501
Rance, M., Sørensen, O.W., Bodenhausen, G., Wagner, G., Ernst, R.R., Wüthrich, K., Improved spectral resolution in cosy 1H NMR spectra of proteins via double quantum filtering (1983) Biochem. Biophys. Res. Commun, 117, pp. 479-485
Braunschweiler, L., Ernst, R.R., Coherence transfer by isotropic mixing - application to proton correlation spectroscopy (1983) J. Magn. Reson, 53, pp. 521-528
Kumar, A., Ernst, R.R., Wüthrich, K., A two-dimensional nuclear Overhauser enhancement (2D NOE) experiment for the elucidation of complete proton-proton cross-relaxation networks in biological macromolecules (1980) Biochem. Biophys. Res. Commun, 95, pp. 1-6
Griesinger, C., Ernst, R.R., Frequency offset effects and their elimination in NMR rotating-frame cross-relaxation spectroscopy (1987) J. Magn. Reson, 75, pp. 261-271
Hwang, T.L., Shaka, A.J., Water suppression that works: Excitation sculpting using arbitrary wave-forms and pulsed-field gradients (1995) J. Magn. Reson., Ser. A, 112, pp. 275-279
Dalvit, C., Efficient multiple-solvent suppression for the study of the interactions of organic solvents with biomolecules (1998) J. Biomol. NMR, 11, pp. 437-444
Bartels, C., Xia, T., Billeter, M., Wüthrich, K., The program XEASY for computer-supported NMR spectral analysis of biological macromolecules (1995) J. Biomol. NMR, 5, pp. 1-10
Keller, R., (2004) The Computer Aided Resonance Assignment Tutorial, , ISBN 3-85600-112-3. CANTINA Verlag: Goldau
Güntert, P., Mumenthaler, C., Wüthrich, K., Torsion angle dynamics for NMR structure calculationwith the new program DYANA (1997) J. Mol. Biol, 273, pp. 283-298
Koradi, R., Billeter, M., Wüthrich, K., MOLMOL: A program for display and analysis of macromolecular structures (1996) J. Mol. Graphics, 14, pp. 51-55
Mishell, R.I., Dutton, R., Immunization of dissociated spleen cell cultures from normal mice (1967) J. Exp.Med, 126, pp. 426-443
Lagrange, P.H., Mackaness, G.B., Miller, T.E., Pardon, P., Influence of dose and route of antigen injection on the immunological induction of T cells (1974) J. Exp. Med, 139, pp. 528-542
Wüthrich, K., (1986) NMR of Proteins and Nucleic Acids, , Wiley-Interscience: New York
Berliner, L.J., Reuben, J., (1980) Biological Magnetic Resonance, 2, pp. 286-288. , Plenum Press: New York
Karle, I., Wieland, T., Fourth polymorph of [Phe4 Val6] antamanide (pentahydrate) (1987) Int. J. Pept. Protein Res, 29, pp. 596-603
Kessler, H., Bats, J.W., Lautz, J., Müller, A., Conformation of antamanide (1989) Liebigs Ann. Chem, pp. 913-928
PolS, D., Zorn, C., Klein, C.D., Zerbe, O., Reiser, O., Surprisingly stable helical conformations in α/β-peptides by incorporation of cis-β-aminocyclopropane carboxylic acids (2004) Angew. Chem., Int. Ed. Engl, 43, pp. 511-514
Zimmerman, S.S., Pottle, M.S., Nemethy, G., Scheraga, H.A., Conformational analysis of th 20 naturally occurring amino acid residues using ECEPP (1977) Macromolecules, 10, pp. 1-9
Zimecki, M., Wieczorek, Z., A biorhythm in the humoral immune response to SRBC in mice (1991) Arch. Immunol. Ther. Exp, 39, pp. 485-488
Ellis, G. P., West, G. B., Cyclosporins, fungal metabolites with immunosuppressive activities (1998) Prog. Med. Chem, 25, pp. 1-3
Kaufmann, H. P., Tobschirbel, A., Ueber ein oligopeptid aus leinsamen. (1959) Chem. Ber, 92, pp. 2805-2809
Siemion, I. Z., Cebrat, M., Wieczorek, Z., Cyclolinopeptide and their analogs - a new family of peptide immunosuppressants affecting the calcineurin system (1999) Arch. Immunol. Ther. Exp, 47, pp. 143-153
Siemion, I. Z., P dyczak, A., Strug, I., Wieczorek, Z., Synthesis and biological studies on analogs of Cyclolinopeptide A with a shortened peptide chain (1994) Arch. Immunol. Ther. Exp, 42, pp. 459-465
Wang, S. S., Gisin, B. F., Winter, D. P., Makofske, R., Kulesha, I. D., Tzougraki, C., Meienhofer, J., Facile synthesis of amino acid and peptide esters under mild conditions via cesium salts (1977) J. Org. Chem, 42, pp. 1286-1290
Stewart, J. M., Solid Phase Peptide Synthesis (1984) Pierce Chem, , Corp, Rockfort, IL
Li, P., Roller, P. P., Cyclization strategies in peptide derived drug design (2002) Curr. Top. Med. Chem, 2, pp. 325-341
Davies, J. S., The cyclization of peptides and depsipeptides (2003) J. Pept. Sci, 9, pp. 471-501
Rance, M., S rensen, O. W., Bodenhausen, G., Wagner, G., Ernst, R. R., W thrich, K., Improved spectral resolution in cosy 1H NMR spectra of proteins via double quantum filtering (1983) Biochem. Biophys. Res. Commun, 117, pp. 479-485
Hwang, T. L., Shaka, A. J., Water suppression that works: Excitation sculpting using arbitrary wave-forms and pulsed-field gradients (1995) J. Magn. Reson., Ser. A, 112, pp. 275-279
G ntert, P., Mumenthaler, C., W thrich, K., Torsion angle dynamics for NMR structure calculationwith the new program DYANA (1997) J. Mol. Biol, 273, pp. 283-298
Mishell, R. I., Dutton, R., Immunization of dissociated spleen cell cultures from normal mice (1967) J. Exp. Med, 126, pp. 426-443
Lagrange, P. H., Mackaness, G. B., Miller, T. E., Pardon, P., Influence of dose and route of antigen injection on the immunological induction of T cells (1974) J. Exp. Med, 139, pp. 528-542
W thrich, K., (1986) NMR of Proteins and Nucleic Acids, , Wiley-Interscience: New York
Berliner, L. J., Reuben, J., (1980) Biological Magnetic Resonance, 2, pp. 286-288. , Plenum Press: New York
Zimmerman, S. S., Pottle, M. S., Nemethy, G., Scheraga, H. A., Conformational analysis of th 20 naturally occurring amino acid residues using ECEPP (1977) Macromolecules, 10, pp. 1-9
Synthesis, conformational analysis and immunological activity of β3Phe-substituted Cyclolinopeptide A analogues
CLA, a natural, highly hydrophobic cyclic nonapeptide with sequence c(Pro1-Pro2- Phe3-Phe4- Leu5-Ile6- Ile7-Leu8- Val9-), isolated from linseed oil, was found to possess a strong immunosuppressive activity comparable, in low doses, with that of CsA, with a mechanism that depends on the inhibition of the interleukin-1 and interleukin-2 action. Structural analysis of CLA and its related compounds has underlined that the presence of the tetrapeptide Pro-Pro-Phe-Phe sequence, the Pro-Pro cis amide bond, and the 'edge-to-face' interaction are possible important features for the immunosuppressive activity of CLA. To evaluate the role and significance of 'edge-to-face' interaction in the process of molecular recognition by receptors, we have synthesised three linear precursors and three cyclic analogues of CLA, in which one or both Phe residues have been replaced by β3Phe residues. A conformational analysis byNMR in CD3CN/H2O mixture has been carried out on the CLA analogue, in which Phe3 has been replaced by a βPhe, to study the influence of the mutation on the three-dimensional structure. All linear and cyclic CLA analogues containing βPhe have been tested in the humoral and cellular immune response in vivo assays in mice. The peptide activities have been compared with CsA, as a reference drug. Copyright © 2008 European Peptide Society and John Wiley & Sons, Ltd.
CLA, a natural, highly hydrophobic cyclic nonapeptide with sequence c(Pro1-Pro2- Phe3-Phe4- Leu5-Ile6- Ile7-Leu8- Val9-), isolated from linseed oil, was found to possess a strong immunosuppressive activity comparable, in low doses, with that of CsA, with a mechanism that depends on the inhibition of the interleukin-1 and interleukin-2 action. Structural analysis of CLA and its related compounds has underlined that the presence of the tetrapeptide Pro-Pro-Phe-Phe sequence, the Pro-Pro cis amide bond, and the 'edge-to-face' interaction are possible important features for the immunosuppressive activity of CLA. To evaluate the role and significance of 'edge-to-face' interaction in the process of molecular recognition by receptors, we have synthesised three linear precursors and three cyclic analogues of CLA, in which one or both Phe residues have been replaced by β3Phe residues. A conformational analysis byNMR in CD3CN/H2O mixture has been carried out on the CLA analogue, in which Phe3 has been replaced by a βPhe, to study the influence of the mutation on the three-dimensional structure. All linear and cyclic CLA analogues containing βPhe have been tested in the humoral and cellular immune response in vivo assays in mice. The peptide activities have been compared with CsA, as a reference drug. Copyright © 2008 European Peptide Society and John Wiley & Sons, Ltd.
Synthesis, conformational analysis and immunological activity of β3Phe-substituted Cyclolinopeptide A analogues
Synthesis, conformational analysis and immunological activity of β3Phe-substituted Cyclolinopeptide A analogues
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Zanotti G, Falcigno L, Saviano M, D'Auria G, Bruno BM, Campanile T, Paolillo L
* Solid state and solution conformation of [Ala7]-phalloidin: A synthetic phallotoxin analogue (476 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2001; 7(7): 1479-1485.
Impact Factor: 4.614
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Saviano M, Isernia C, Rossi F, Di Blasio B, Iacovino R, Mazzeo M, Pedone C, Benedetti E
Solid state structural analysis of the cyclooctapeptide cyclo-(Pro(1)-Pro-Phe-Phe-Ac(6)c-Ile-D-Ala-Val(8)) (426 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2000 Feb; 53(2): 189-199.
Impact Factor: 2.405
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Gallo P, Rossi F, Saviano M, Pedone C, Colonna G, Ragone R
Specific interaction between bovine cyclophilin A and synthetic analogues of cyclolinopeptide (393 views)
Journal Of Biochemistry (ISSN: 0021-924x), 1998 Nov; 124(5): 880-885.
Impact Factor: 2.189
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Zanotti G, Saviano M, Saviano G, Tancredi T, Rossi F, Pedone C, Benedetti E
Structure of cyclic peptides: the crystal and solution conformation of cyclo(Phe-Phe-Aib-Leu-Pro) (593 views)
Journal Of Peptide Research (ISSN: 1397-002x), 1998 Jun; 51(6): 460-466.
Impact Factor: 1.125
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Lombardi A, D'Agostino B, Nastri F, D'Andrea LD, Filippelli A, Falciani M, Rossi F, Pavone V
A novel super-potent neurokinin A receptor antagonist containing dehydroalanine (463 views)
Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894xprint, 0960-894xlinking), 1998 May 19; 8(10): 1153-1156.
Impact Factor: 1.5
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Lombardi A, D'Auria G, Maglio O, Nastri F, Quartara L, Pedone C, Pavone V
A novel rigid β-turn molecular scaffold (454 views)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 1998; 120(24): 5879-5886.
Impact Factor: 5.725
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Bonomo RP, Impellizzeri G, Pappalardo G, Purrello R, Rizzarelli E, Tabbì G
Co-ordinating properties of cyclopeptides. Thermodynamic and spectroscopic study on the formation of copper(II) complexes with cyclo(Gly-His)4 and cyclo(Gly-His-Gly)2 and their superoxide dismutase-like activity (452 views)
Journal Of The Chemical Society Dalton Transactions (ISSN: 0300-9246), 1998; (22): 3851-3857.
Impact Factor: 2.507
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Impellizzeri G, Pappalardo G, Purrello R, Rizzarelli E, Santoro AM
Synthesis, spectroscopic characterisation, and metal ion interaction of a new α-helical peptide (490 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 1998; 4(9): 1791-1798.
Impact Factor: 5.153
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D'Auria G, Maglio O, Nastri F, Lombardi A, Mazzeo M, Morelli G, Paolillo L, Pedone C, Pavone V
Hemoprotein models based on a covalent helix-heme-helix sandwich: 2. Structural characterization of Co(III) mimochrome I Δ and Λ isomers (486 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 1997; 3(3): 350-362.
Impact Factor: 4.828
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D'Andrea LD, Mazzeo M, Isernia C, Rossi F, Saviano M, Gallo P, Paolillo L, Pedone C
Solution conformational preferences of a peptidic analogue of a natural macrolide (382 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1997; 42(3): 349-361.
Impact Factor: 2.425
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Lombardi A, Saviano M, Nastri F, Maglio O, Mazzeo M, Pedone C, Isernia C, Pavone V
Unusual conformational preferences of β-alanine containing cyclic peptides. VII (456 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1996 Jun; 38(6): 683-691.
Impact Factor: 2.425
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Rossi F, Saviano M, Di Talia P, Di Blasio B, Pedone C, Zanotti G, Mosca M, Saviano G, Tancredi T, Ziegler K, Benedetti E
Solution and solid state structure of an aib-containing cyclodecapeptide inhibiting the cholate uptake in hepatocytes (455 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1996; 40(5): 465-478.
Impact Factor: 2.425
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Saviano M, Rossi F, Filizola M, Isernia C, Di Blasio B, Benedetti E, Pedone C, Siemion IZ, Pedyczak A
Bioactive peptides: conformational studies of [Tyr4] cyclolinopeptide (406 views)
Biopolymers (ISSN: 0006-3525print, 0006-3525linking, 1097-0282electronic), 1995 Oct; 26(12): 453-460.
Impact Factor: 2.572
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Mazzeo M, Isernia C, Rossi F, Saviano M, Pedone C, Paolillo L, Benedetti E, Pavone V
Conformational Behaviour of a Cyclolinopeptide A Analogue: Two-dimensional NMR study of cyclo(Pro(1)-Pro-Phe-Phe-Ac(6)c-Ile-ala-Val(8)) (320 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 1995 Sep; 1(5): 330-340.
Impact Factor: 1.311
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Gallo P, Saviano M, Rossi F, Pavone V, Pedone C, Ragone R, Stiuso P, Colonna G
SPECIFIC INTERACTION BETWEEN CYCLOPHILIN AND CYCLIC-PEPTIDES (484 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1995 Sep; 36(3): 273-281.
Impact Factor: 2.425
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Saviano M, Rossi F, Filizola M, Di Blasio B, Pedone C
[Aib5, 6-D-Ala8]-cyclolinopeptide A, grown from a benzene/acetonitrile mixture (324 views)
Acta Crystallogr Sect C Cryst Struct Commun (ISSN: 0108-2701), 1995 Apr 15; 51: Pt-Pt.
Impact Factor: 0.459
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Fattorusso R, Morelli G, Lombardi A, Nastri F, maglio O, D'Auria G, Pedone C, Pavone V
Design of metal ion binding peptides (614 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1995; 37(6): 401-410.
Impact Factor: 2.425
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Pavone V, Lombardi A, Saviano M, Nastri F, Fattorusso R, Maglio O, Isernia C, Paolillo L, Pedone C
β-alanine containing cyclic peptides with turned structure: The 'pseudo type II β-turn. ' VI (463 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1994 Nov; 34(11): 1517-1526.
Impact Factor: 2.425
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Rossi F, Saviano M, Di Blasio B, Zanotti G, Maione AM, Tancredi T, Pedone C
BIOACTIVE PEPTIDES - SOLID-STATE, SOLUTION AND MOLECULAR-DYNAMICS STUDIES OF A CYCLOLINOPEPTIDE-A RELATED CYSTINYL CYCLOPENTAPEPTIDE (455 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1994 Feb; 34(2): 273-284.
Impact Factor: 2.425
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Di Blasio B, Lombardi A, D'Auria G, Saviano M, Isernia C, Maglio O, Paolillo L, Pedone C, Pavone V
Beta-Alanine Containing Peptides: Gamma-Turns In Cyclotetrapeptides (560 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1993 Apr; 31(10): 621-631.
Impact Factor: 2.425
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DIBLASIO B, ROSSI F, BENEDETTI E, PAVONE V, SAVIANO M, PEDONE C, ZANOTTI G, TANCREDI T
BIOACTIVE PEPTIDES - X-RAY AND NMR CONFORMATIONAL STUDY OF [AIB(5, 6)-D-ALA(8)]CYCLOLINOPEPTIDE-A (441 views)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 1992 Oct 7; 114(21): 8277-8283.
Impact Factor: 5.65
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Saviano M, Rossi F, Pavone V, Di Blasio B, Pedone C
Molecular dynamics simulation in vacuo and in solution of [Aib5, 6-D- Ala8] Cyclolinopeptide A: A conformational and comparative study (443 views)
J Biomol Struct Dyn (ISSN: 0739-1102, 1538-0254electronic, 0739-1102linking), 1992 Jun; 9(6): 1045-1060.
Impact Factor: 1.283
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Tancredi T, Benedetti E, Grimaldi M, Pedone C, Rossi F, Saviano M, Temussi PA, Zanotti G
Ion binding of cyclolinopeptide A: An NMR and CD conformational study (633 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1991 May; 31(6): 761-767.
Impact Factor: 2.425
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Cucinotta V, D'Alessandro F, Impellizzeri G, Pappalardo G, Rizzarelli E, Vecchio G
Cyclopeptide Functionalized beta-Cyclodextrin. A New Class of Potentially Enzyme Mimicking Compound with Two Recognition Sites (267 views)
Chem Commun, 1991; N/D: 293-294.
Impact Factor: 0
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Zanotti G, Tancredi T, Rossi F, Benedetti E, Pedone C, Temussi P
Ala analogues of the cyclolinopeptide (443 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1989 Jan; 28(1): 371-383.
Impact Factor: 2.425
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Tancredi T, Zanotti G, Rossi F, Benedetti E, Pedone C, Temussi PA
Comparison of the conformations of cyclolinopeptide A in the solid state and in solution (423 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1989 Jan; 28(1): 513-523.
Impact Factor: 2.425
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Blasio BD, Rossi F, Benedetti E, Pavone V, Pedone C, Temussi PA, Zanotti G, Tancredi T
Bioactive peptides: Solid-state and solution conformation of cyclolinopeptide (549 views)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 1989; 111(25): 9089-9098.
Impact Factor: 5.65
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Arena G, Impellizzeri G, Maccarrone G, Pappalardo G, Sciotto D, Rizzarelli E
Non-Covalent Interactions in Cyclopeptide Proton Complex Formation in Aqueous Solution (308 views)
Thermochim Acta, 1989; 154: 97-106.
Impact Factor: 0
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* NMR spectroscopy in the conformational analysis of peptides: an overview (91 views)
Curr Med Chem (ISSN: 0929-8673linking, 1875-533xelectronic), 2021; 28(14): 2729-2782.
Impact Factor: 4.184
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Riccardi C, Capasso D, Coppola A, Platella C, Montesarchio D, Di Gaetano S, Roviello GN, Musumeci D
* Synthesis, Antiproliferative Activity, and DNA Binding Studies of Nucleoamino Acid-Containing Pt(II) Complexes (150 views)
Pharmaceuticals (ISSN: 1424-8247linking, 1424-8247print), 2020 Sep 30; 13(10): 284-284.
Impact Factor: 4.421
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Mercurio FA, Di Natale C, Pirone L, Vincenzi M, Marasco D, De Luca S, Pedone EM, Leone M
* Exploring the ability of cyclic peptides to target SAM domains: a computational and experimental study (266 views)
Chembiochem (ISSN: 1439-4227linking, 1439-7633), 2020 Mar 2; 21(5): 702-711.
Impact Factor: 2.641
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Riccardi C, Capasso D, Rozza GM, Platella C, Montesarchio D, Di Gaetano S, Marzo T, Pratesi A, Messori L, Roviello GN, Musumeci D
* Synthesis, DNA binding studies, and antiproliferative activity of novel Pt(II)- complexes with an L-alanyl-based ligand (261 views)
J Chem Res (ISSN: 0162-0134linking, 0162-0134print), 2020 Feb; 203: 110868-110868.
Impact Factor: 3.224
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Farina B, Del Gatto A, Comegna D, Di Gaetano S, Capasso D, Isernia C, Saviano M, Fattorusso R, Zaccaro L, Russo L
* Conformational studies of RGDechi peptide by natural-abundance NMR spectroscopy (251 views)
J Pept Sci (ISSN: 1075-2617linking, 1099-1387electronic), 2019 May; 25(5): e3166-e3166.
Impact Factor: 1.807
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Lanza V, Milardi D, Di Natale G, Pappalardo G
* Repurposing of Copper(II)-chelating Drugs for the Treatment of Neurodegenerative Diseases (708 views)
Curr Med Chem (ISSN: 1875-533xelectronic, 0929-8673linking), 2018 Feb 12; 25(4): 525-539.
Impact Factor: 3.249
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Grage SL, Kara S, Bordessa A, Doan V, Rizzolo F, Putzu M, Kubar T, Papini AM, Chaume G, Brigaud T, Afonin S, Ulrich AS
* Orthogonal (19) F-Labeling for Solid-State NMR Spectroscopy Reveals the Conformation and Orientation of Short Peptaibols in Membranes (347 views)
Chemistry (ISSN: 1521-3765electronic, 0947-6539linking), 2018 Jan 11; N/D: N/D-N/D.
Impact Factor: 5.476
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Di Stasi R, Diana D, Capasso D, Di Gaetano S, De Rosa L, Celentano V, Isernia C, Fattorusso R, D'Andrea LD
* VEGFR Recognition Interface of a Proangiogenic VEGF-Mimetic Peptide Determined In Vitro and in the Presence of Endothelial Cells by NMR Spectroscopy (338 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2018; 24(44): 11461-11466.
Impact Factor: 5.16
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Calvanese L, Foca A, Sandomenico A, Foca G, Caporale A, Doti N, Iaccarino E, Leonardi A, D'Auria G, Ruvo M, Falcigno L
* Structural insights into the interaction of a monoclonal antibody and Nodal peptides by STD-NMR spectroscopy (499 views)
Bioorg Med Chem (ISSN: 0968-0896, 1464-3391, 0968-0896linking), 2017 Dec 15; 25(24): 6589-6596.
Impact Factor: 2.881
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Calvanese L, Caporale A, Focà G, Iaccarino E, Sandomenico A, Doti N, Apicella I, Incisivo GM, De Falco S, Falcigno L, D’auria G, Ruvo M
* Targeting VEGF receptors with non-neutralizing cyclopeptides for imaging applications (496 views)
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2017 Dec 2; 50(2): 321-329.
Impact Factor: 2.906
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Cavallari E, Carrera C, Aime S, Reineri F
* (13) C MR Hyperpolarization of Lactate by Using ParaHydrogen and Metabolic Transformation in Vitro (251 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2017 Jan 23; 23(5): 1200-1204.
Impact Factor: 5.16
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Celentano V, Diana D, Di Salvo C, De Rosa L, Romanelli A, Fattorusso R, D'Andrea LD
* 1, 2, 3-Triazole Bridge as Conformational Constrain in beta-Hairpin Peptides: Analysis of Hydrogen-Bonded Positions (442 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2016 Apr 11; 22(16): 5534-5537.
Impact Factor: 5.317
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Farina B, De Paola I, Russo L, Capasso D, Liguoro A, Gatto AD, Saviano M, Pedone PV, Di Gaetano S, Malgieri G, Zaccaro L, Fattorusso R
* A Combined NMR and Computational Approach to Determine the RGDechi-hCit-alphav beta3 Integrin Recognition Mode in Isolated Cell Membranes (628 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2016 Jan 11; 22(2): 681-693.
Impact Factor: 5.317
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Bottini A, Wu B, Barile E, De SK, Leone M, Pellecchia M
* High-Throughput Screening (HTS) by NMR Guided Identification of Novel Agents Targeting the Protein Docking Domain of YopH (422 views)
Chemmedchem (ISSN: 1860-7179, 1860-7187, 1860-7179linking), 2015 Nov 23; 11(8): 919-927.
Impact Factor: 2.98
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Smaldone G, Diana D, Pollegioni L, Di Gaetano S, Fattorusso R, Pedone E
* Insight into conformational modification of alpha-synuclein in the presence of neuronal whole cells and of their isolated membranes (435 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468), 2015 Feb 18; 589(7): 798-804.
Impact Factor: 3.519
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Diana D, Russomanno A, De Rosa L, Di Stasi R, Capasso D, Di Gaetano S, Romanelli A, Russo L, D'Andrea LD, Fattorusso R
* Functional Binding Surface Of A Beta-Hairpin Vegf Receptor Targeting Peptide Determined By Nmr Spectroscopy In Living Cells (444 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2015 Jan 2; 21(1): 91-95.
Impact Factor: 5.771
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di Villa Bianca R, Mitidieri E, Donnarumma E, Fusco F, Longo N, Rosa GD, Novellino E, Grieco P, Mirone V, Cirino G, Sorrentino R
* A new therapeutic approach to erectile dysfunction: urotensin-II receptor high affinity agonist ligands (476 views)
Asian J Androl (ISSN: 1008-682x), 2015 Jan; 17(1): 81-85.
Impact Factor: 2.644
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Mercurio FA, Di Natale C, Pirone L, Scognamiglio PL, Marasco D, Pedone EM, Saviano M, Leone M
* Peptide Fragments of Odin-Sam1: Conformational Analysis and Interaction Studies with EphA2-Sam (464 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-4227linking), 2015; 16(11): 1629-1636.
Impact Factor: 2.85
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Vitale RM, Zaccaro L, Di Blasio B, Fattorusso R, Isernia C, Amodeo P, Pedone C, Saviano M
* Conformational features of human melanin-concentrating hormone: an NMR and computational analysis (457 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-4227linking), 2014 Sep 17; 4(1): 73-81.
Impact Factor: 3.088
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De Rosa L, Diana D, Basile A, Russomanno A, Isernia C, Turco MC, Fattorusso R, D'Andrea LD
* Design, Structural And Biological Characterization Of A Vegf Inhibitor Beta-Hairpin-Constrained Peptide (508 views)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 0223-5234linking), 2014; 73: 210-216.
Impact Factor: 3.447
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Portella L, Vitale R, De Luca S, D'Alterio C, Ieranò C, Napolitano M, Riccio A, Polimeno MN, Monfregola L, Barbieri A, Luciano A, Ciarmiello A, Arra C, Castello G, Amodeo P, Scala S
* Preclinical Development of a Novel Class of CXCR4 Antagonist Impairing Solid Tumors Growth and Metastases (503 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2013 Sep 13; 8(9): N/D-N/D.
Impact Factor: 3.534
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Diana D, Smaldone G, De Antonellis P, Pirone L, Carotenuto M, Alonzi A, Di Gaetano S, Zollo M, Pedone E, Fattorusso R
* Mapping Functional Interaction Sites of Human Prune C-Terminal Domain by NMR Spectroscopy in Human Cell Lysates (389 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2013 Sep 9; 19(37): 12217-12220.
Impact Factor: 5.696
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Farina B, Doti N, Pirone L, Malgieri G, Pedone E, Ruvo M, Fattorusso R
* Molecular basis of the PED/PEA15 interaction with the C-terminal fragment of phospholipase D1 revealed by NMR spectroscopy (469 views)
Bba-Gen Subjects (ISSN: 1570-9639, 0006-3002, 0925-4439), 2013 Sep; 1834(8): 1572-1580.
Impact Factor: 3.191
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Mercurio FA, Marasco D, Pirone L, Scognamiglio PL, Pedone E, Pellecchia M, Leone M
* Heterotypic Sam-Sam Association Between Odin-Sam1 And Arap3-Sam: Binding Affinity And Structural Insights (372 views)
Chembiochem (ISSN: 1439-4227, 1439-9422, 1439-7633), 2013 Jan 2; 14(1): 100-106.
Impact Factor: 2.92
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Carotenuto A, Cipolletta E, Gomez-Monterrey I, Sala M, Vernieri E, Limatola A, Bertamino A, Musella S, Sorriento D, Grieco P, Trimarco B, Novellino E, Iaccarino G, Campiglia P
* Design, synthesis and efficacy of novel G protein-coupled receptor kinase 2 inhibitors (527 views)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 1768-3254electronic), 2013; 69: 384-392.
Impact Factor: 3.432
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Malgieri G, Zaccaro L, Leone M, Bucci E, Esposito S, Baglivo I, Del Gatto A, Russo L, Scandurra R, Pedone PV, Fattorusso R, Isernia C
* Zinc to Cadmium Replacement in the A. thaliana SUPERMAN Cys(2)His(2) Zinc Finger Induces Structural Rearrangements of Typical DNA Base Determinant Positions (445 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2011 Nov; 95(11): 801-810.
Impact Factor: 2.87
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Saviano M, Del Gatto A, De Simone M, De Paola I, Saviano M, Zaccaro L
* Investigation of the Best Conditions to Obtain c(RGDfK) Peptide on Solid Phase (508 views)
Int J Pept Res Ther (ISSN: 1573-3149, 0929-5666), 2011 Mar; 17(1): 39-45.
Impact Factor: 0.986
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Accardo A, Morisco A, Gianolio E, Tesauro D, Mangiapia G, Radulescu A, Brandt A, Morelli G
* Nanoparticles containing octreotide peptides and gadolinium complexes for MRI applications (504 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2011 Feb; 17(2): 154-162.
Impact Factor: 1.799
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Santulli G, Basilicata MF, De Simone M, Del Giudice C, Anastasio A, Sorriento D, Saviano M, Del Gatto A, Trimarco B, Pedone C, Zaccaro L, Iaccarino G
* Evaluation of the anti-angiogenic properties of the new selective alphaVbeta3 integrin antagonist RGDechiHCit (511 views)
J Transl Med (ISSN: 1479-5876electronic), 2011 Jan 13; 9: 7-7.
Impact Factor: 3.474
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Barile E, Leone M, Barile E, Dahl R, Pellecchia M
* Design and NMR Studies of Cyclic Peptides Targeting the N-Terminal Domain of the Protein Tyrosine Phosphatase YopH (2177 views)
Chem Biol Drug Des (ISSN: 1747-0277, 1747-0285), 2011 Jan; 77(1): 12-19.
Impact Factor: 2.282
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Cucinotta V, Giuffrida A, Grasso G, MacCarrone G, Mazzaglia A, Messina M, Vecchio G
* Diaminotrehalose-capped β-cyclodextrin, a new member of hemispherodextrins: Synthesis, thermodynamic and spectroscopic characterization and its exploitation in chiral electrokinetic chromatography (400 views)
J Sep Sci (ISSN: 1615-9306), 2011 Jan; 34(1): 70-76.
Impact Factor: 2.733
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Verardi R, Traaseth NJ, Shi L, Porcelli F, Monfregola L, De Luca S, Amodeo P, Veglia G, Scaloni A
* Probing membrane topology of the antimicrobial peptide distinctin by solid-state NMR spectroscopy in zwitterionic and charged lipid bilayers (486 views)
Bba-Gen Subjects (ISSN: 0005-2736, 0006-3002, 0925-4439), 2011 Jan; 1808(1): 34-40.
Impact Factor: 3.99
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Farina B, Pirone L, Russo L, Viparelli F, Doti N, Pedone C, Pedone E, Fattorusso R
* NMR backbone dynamics studies of human PED/PEA-15 outline protein functional sites (675 views)
Febs J (ISSN: 1742-4658, 1742-464x, 1742-4658electronic), 2010 Oct; 277(20): 4229-4240.
Impact Factor: 3.129
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Gautier B, Goncalves V, Diana D, Di Stasi R, Teillet F, Lenoir C, Huguenot F, Garbay C, Fattorusso R, D'Andrea LD, Vidal M, Inguimbert N
* Biochemical and Structural Analysis of the Binding Determinants of a Vascular Endothelial Growth Factor Receptor Peptidic Antagonist (541 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2010 Jun 10; 53(11): 4428-4440.
Impact Factor: 5.207
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Diana D, Ziaco B, Scarabelli G, Pedone C, Colombo G, D'Andrea LD, Fattorusso R
* Structural analysis of a helical peptide unfolding pathway (461 views)
Chemistry (ISSN: 1521-3765, 0947-6539, 1521-3765electronic), 2010 May 10; 16(18): 5400-5407.
Impact Factor: 5.476
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Abbate M, Casella G, Fiore T, Grasso G, Pellerito C, Scopelliti M, Spinella A, Pellerito L
* Structural characterization of triorganotin(IV) complexes with sodium fusidate and DFT calculations (377 views)
J Organomet Chem (ISSN: 0022-328x), 2010 May 1; 695(9): 1405-1413.
Impact Factor: 2.205
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Puglisi A, Rizzarelli E, Vecchio G, Iacovino R, Benedetti E, Pedone C, Saviano M
* Crystal And Molecular Structure Of Beta-Cyclodextrins Functionalized With The Anti-Inflammatory Drug Etodolac (416 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2009 Dec; 91(12): 1227-1235.
Impact Factor: 2.605
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Diana D, Ziaco B, Colombo G, Scarabelli G, Romanelli A, Fedone C, Fattorusso R, D'Andrea LD
* Structural determinants of the unusual helix stability of a de novo engineered vascular endothelial growth factor (VEGF) mimicking peptide (470 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2008; 14(14): 4164-4166.
Impact Factor: 5.454
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Malgieri G, Russo L, Esposito S, Baglivo I, Zaccaro L, Pedone EM, Di Blasio B, Isernia C, Pedone PV, Fattorusso R
* The Prokaryotic Cys2his2 Zinc Finger Domain Adopts A Novel Fold As Revealed By The Solution Structure Of Agrobacterium Tumefaciens Ros Dna Binding Domain (462 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2007 Oct 30; 104(44): 17341-17346.
Impact Factor: 9.598
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De Luca S, De Capua A, Saviano M, Della Moglie R, Aloj L, Tarallo L, Pedone C, Morelli G
* Synthesis and biological evaluation of cyclic and branched peptide analogues as ligands for cholecystokinin type 1 receptor (398 views)
Bioorg Med Chem (ISSN: 0968-0896, 1464-3391, 1464-3391electronic), 2007 Sep 1; 15(17): 5845-5853.
Impact Factor: 2.662
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De Pinto V, Tomasello F, Messina A, Guarino F, Benz R, La Mendola D, Magrì A, Milardi D, Pappalardo G
* Determination of the conformation of the human VDAC1 N-terminal peptide, a protein moiety essential for the functional properties of the pore (470 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2007 May 7; 8(7): 744-756.
Impact Factor: 3.446
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Milardi D, Arnesano F, Grasso G, Magrì A, Tabbì G, Scintilla S, Natile G, Rizzarelli E
* Ubiquitin stability and the Lys63-linked polyubiquitination site are compromised on copper binding (378 views)
Angew Chem Int Ed (ISSN: 1433-7851, 1521-3773electronic, 1433-7851linking), 2007; 46(42): 7993-7995.
Impact Factor: 10.031
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Galdiero S, Vitiello M, Amodeo P, D'Isanto M, Cantisani M, Pedone C, Galdiero M
* Structural requirements for proinflammatory activity of porin P2 loop 7 from Haemophilus influenzae (514 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2006 Apr 11; 45(14): 4491-4501.
Impact Factor: 3.633
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De Capua A, Goodman M, Amino Y, Saviano M, Benedetti E
* Conformation analysis of aspartame-based sweeteners by NMR spectroscopy, molecular dynamics simulations, and X-ray diffraction studies (614 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2006 Feb; 7(2): 377-387.
Impact Factor: 4.1
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D'Andrea LD, Iaccarino G, Fattorusso R, Sorriento D, Carannante C, Capasso D, Trimarco B, Pedone C
* Targeting angiogenesis: Structural characterization and biological properties of a de novo engineered VEGF mimicking peptide (653 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2005 Oct 4; 102(40): 14215-14220.
Impact Factor: 10.231
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Benedetti E, Pedone C
* Cyclolinopeptide A: inhibitor, immunosuppressor or other? (568 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2005 May; 11(5): 268-272.
Impact Factor: 1.803
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Cozzolino R, Palladino P, Rossi F, Cali G, Benedetti E, Laccetti P
* Antineoplastic cyclic astin analogues kill tumour cells via caspase-mediated induction of apoptosis (524 views)
Carcinogenesis (ISSN: 0143-3334), 2005 Apr; 26(4): 733-739.
Impact Factor: 5.108
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Zubrzak P, Banas A, Kaczmarek K, Leplawy MT, Sochacki M, Kowalski ML, Szkudlinska B, Zabrocki J, Di Lello P, Isernia C, Saviano M, Pedone C, Benedetti E
* Analogues of cyclolinopeptide A containing alpha-hydroxymethyl amino acid residues (469 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2005; 80(2-3): 347-356.
Impact Factor: 2.425
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Falcigno L, Oliva R, D'Auria G, Maletta M, Dettin M, Pasquato A, Di Bello C, Paolillo L
* Structural investigation of the HIV-1 envelope glycoprotein gp160 cleavage site 3: Role of site-specific mutations (419 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2004 Dec 3; 5(12): 1653-1661.
Impact Factor: 3.474
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De Luca S, Morelli G
* Synthesis and characterization of a sulfated and a non-sulfated cyclic CCK8 analogue functionalized with a chelating group for metal labelling (395 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2004 May; 10(5): 265-273.
Impact Factor: 1.652
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Lombardi A, Nastri F, Marasco D, Maglio O, De Sanctis G, Sinibaldi F, Santucci R, Coletta M, Pavone V
* Design of a new mimochrome with unique topology (534 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2003 Nov 21; 9(22): 5643-5654.
Impact Factor: 4.353
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De Luca S, Ragone R, Bracco C, Digilio G, Aloj L, Tesauro D, Saviano M, Pedone C, Morelli G
* A cyclic CCK8 analogue selective for the cholecystokinin type A receptor: design, synthesis, NMR structure and binding measurements (472 views)
Chembiochem (ISSN: 1439-7633, 1439-4227, 1439-7633electronic), 2003 Nov 7; 4(11): 1176-1187.
Impact Factor: 3.992
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Oliva R, Falcigno L, D'Auria G, Dettin M, Scarinci C, Pasquato A, Di Bello C, Paolillo L
* Structural investigation of the HIV-1 envelope glycoprotein gp160 cleavage site (361 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2003 Sep 4; 4(8): 727-733.
Impact Factor: 3.992
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Oliva R, Falcigno L, D'Auria G, Dettin M, Scarinci C, Pasquato A, Di Bello C, Paolillo L
* Structural investigation of the HIV-1 envelope glycoprotein gp160 cleavage site, 2: relevance of an N-terminal helix (360 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2003 Aug 4; 4(8): 727-733.
Impact Factor: 2.92
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Isernia C, Bucci E, Leone M, Zaccaro L, Di Lello P, Digilio G, Esposito S, Saviano M, Di Blasio B, Pedone C, Pedone PV, Fattorusso R
* NMR structure of the single QALGGH zinc finger domain from the Arabidopsis thaliana SUPERMAN protein (429 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2003 Mar 3; 4(2-3): 171-180.
Impact Factor: 3.992
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Saviano G, Rossi F, Benedetti E, Pedone C, Mierke DF, Maione A, Zanotti G, Tancredi T, Saviano M
* Structural consequences of metal complexation of cyclo[Pro-Phe-Phe-Ala-Xaa]2 decapeptides (447 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2001 Mar 16; 7(6): 1176-1183.
Impact Factor: 4.614
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Monti SM, Gallo M, Ferracane R, Borrelli RC, Ritieni A, Greco ML, Graniti A, Fogliano V
* Analysis of bacterial lipodepsipeptides by matrix-assisted laser desorption/ionisation time-of-flight and high-performance liquid chromatography with electrospray mass spectrometry (437 views)
Rapid Commun Mass Sp (ISSN: 0951-4198, 1097-0231electronic), 2001; 15(8): 623-628.
Impact Factor: 2.478
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Zanotti G, Falcigno L, Saviano M, D'Auria G, Bruno BM, Campanile T, Paolillo L
* Solid state and solution conformation of [Ala7]-phalloidin: A synthetic phallotoxin analogue (476 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2001; 7(7): 1479-1485.
Impact Factor: 4.614
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Saviano M, Isernia C, Rossi F, Di Blasio B, Iacovino R, Mazzeo M, Pedone C, Benedetti E
Solid state structural analysis of the cyclooctapeptide cyclo-(Pro(1)-Pro-Phe-Phe-Ac(6)c-Ile-D-Ala-Val(8)) (426 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2000 Feb; 53(2): 189-199.
Impact Factor: 2.405
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Gallo P, Rossi F, Saviano M, Pedone C, Colonna G, Ragone R
Specific interaction between bovine cyclophilin A and synthetic analogues of cyclolinopeptide (393 views)
Journal Of Biochemistry (ISSN: 0021-924x), 1998 Nov; 124(5): 880-885.
Impact Factor: 2.189
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Zanotti G, Saviano M, Saviano G, Tancredi T, Rossi F, Pedone C, Benedetti E
Structure of cyclic peptides: the crystal and solution conformation of cyclo(Phe-Phe-Aib-Leu-Pro) (593 views)
Journal Of Peptide Research (ISSN: 1397-002x), 1998 Jun; 51(6): 460-466.
Impact Factor: 1.125
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Lombardi A, D'Agostino B, Nastri F, D'Andrea LD, Filippelli A, Falciani M, Rossi F, Pavone V
A novel super-potent neurokinin A receptor antagonist containing dehydroalanine (463 views)
Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894xprint, 0960-894xlinking), 1998 May 19; 8(10): 1153-1156.
Impact Factor: 1.5
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Lombardi A, D'Auria G, Maglio O, Nastri F, Quartara L, Pedone C, Pavone V
A novel rigid β-turn molecular scaffold (454 views)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 1998; 120(24): 5879-5886.
Impact Factor: 5.725
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Bonomo RP, Impellizzeri G, Pappalardo G, Purrello R, Rizzarelli E, Tabbì G
Co-ordinating properties of cyclopeptides. Thermodynamic and spectroscopic study on the formation of copper(II) complexes with cyclo(Gly-His)4 and cyclo(Gly-His-Gly)2 and their superoxide dismutase-like activity (452 views)
Journal Of The Chemical Society Dalton Transactions (ISSN: 0300-9246), 1998; (22): 3851-3857.
Impact Factor: 2.507
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Impellizzeri G, Pappalardo G, Purrello R, Rizzarelli E, Santoro AM
Synthesis, spectroscopic characterisation, and metal ion interaction of a new α-helical peptide (490 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 1998; 4(9): 1791-1798.
Impact Factor: 5.153
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D'Auria G, Maglio O, Nastri F, Lombardi A, Mazzeo M, Morelli G, Paolillo L, Pedone C, Pavone V
Hemoprotein models based on a covalent helix-heme-helix sandwich: 2. Structural characterization of Co(III) mimochrome I Δ and Λ isomers (486 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 1997; 3(3): 350-362.
Impact Factor: 4.828
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D'Andrea LD, Mazzeo M, Isernia C, Rossi F, Saviano M, Gallo P, Paolillo L, Pedone C
Solution conformational preferences of a peptidic analogue of a natural macrolide (382 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1997; 42(3): 349-361.
Impact Factor: 2.425
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Lombardi A, Saviano M, Nastri F, Maglio O, Mazzeo M, Pedone C, Isernia C, Pavone V
Unusual conformational preferences of β-alanine containing cyclic peptides. VII (456 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1996 Jun; 38(6): 683-691.
Impact Factor: 2.425
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Rossi F, Saviano M, Di Talia P, Di Blasio B, Pedone C, Zanotti G, Mosca M, Saviano G, Tancredi T, Ziegler K, Benedetti E
Solution and solid state structure of an aib-containing cyclodecapeptide inhibiting the cholate uptake in hepatocytes (455 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1996; 40(5): 465-478.
Impact Factor: 2.425
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Saviano M, Rossi F, Filizola M, Isernia C, Di Blasio B, Benedetti E, Pedone C, Siemion IZ, Pedyczak A
Bioactive peptides: conformational studies of [Tyr4] cyclolinopeptide (406 views)
Biopolymers (ISSN: 0006-3525print, 0006-3525linking, 1097-0282electronic), 1995 Oct; 26(12): 453-460.
Impact Factor: 2.572
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Mazzeo M, Isernia C, Rossi F, Saviano M, Pedone C, Paolillo L, Benedetti E, Pavone V
Conformational Behaviour of a Cyclolinopeptide A Analogue: Two-dimensional NMR study of cyclo(Pro(1)-Pro-Phe-Phe-Ac(6)c-Ile-ala-Val(8)) (320 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 1995 Sep; 1(5): 330-340.
Impact Factor: 1.311
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Gallo P, Saviano M, Rossi F, Pavone V, Pedone C, Ragone R, Stiuso P, Colonna G
SPECIFIC INTERACTION BETWEEN CYCLOPHILIN AND CYCLIC-PEPTIDES (484 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1995 Sep; 36(3): 273-281.
Impact Factor: 2.425
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Saviano M, Rossi F, Filizola M, Di Blasio B, Pedone C
[Aib5, 6-D-Ala8]-cyclolinopeptide A, grown from a benzene/acetonitrile mixture (324 views)
Acta Crystallogr Sect C Cryst Struct Commun (ISSN: 0108-2701), 1995 Apr 15; 51: Pt-Pt.
Impact Factor: 0.459
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Fattorusso R, Morelli G, Lombardi A, Nastri F, maglio O, D'Auria G, Pedone C, Pavone V
Design of metal ion binding peptides (614 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1995; 37(6): 401-410.
Impact Factor: 2.425
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Pavone V, Lombardi A, Saviano M, Nastri F, Fattorusso R, Maglio O, Isernia C, Paolillo L, Pedone C
β-alanine containing cyclic peptides with turned structure: The 'pseudo type II β-turn. ' VI (463 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1994 Nov; 34(11): 1517-1526.
Impact Factor: 2.425
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Rossi F, Saviano M, Di Blasio B, Zanotti G, Maione AM, Tancredi T, Pedone C
BIOACTIVE PEPTIDES - SOLID-STATE, SOLUTION AND MOLECULAR-DYNAMICS STUDIES OF A CYCLOLINOPEPTIDE-A RELATED CYSTINYL CYCLOPENTAPEPTIDE (455 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1994 Feb; 34(2): 273-284.
Impact Factor: 2.425
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Di Blasio B, Lombardi A, D'Auria G, Saviano M, Isernia C, Maglio O, Paolillo L, Pedone C, Pavone V
Beta-Alanine Containing Peptides: Gamma-Turns In Cyclotetrapeptides (560 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1993 Apr; 31(10): 621-631.
Impact Factor: 2.425
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DIBLASIO B, ROSSI F, BENEDETTI E, PAVONE V, SAVIANO M, PEDONE C, ZANOTTI G, TANCREDI T
BIOACTIVE PEPTIDES - X-RAY AND NMR CONFORMATIONAL STUDY OF [AIB(5, 6)-D-ALA(8)]CYCLOLINOPEPTIDE-A (441 views)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 1992 Oct 7; 114(21): 8277-8283.
Impact Factor: 5.65
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Saviano M, Rossi F, Pavone V, Di Blasio B, Pedone C
Molecular dynamics simulation in vacuo and in solution of [Aib5, 6-D- Ala8] Cyclolinopeptide A: A conformational and comparative study (443 views)
J Biomol Struct Dyn (ISSN: 0739-1102, 1538-0254electronic, 0739-1102linking), 1992 Jun; 9(6): 1045-1060.
Impact Factor: 1.283
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Tancredi T, Benedetti E, Grimaldi M, Pedone C, Rossi F, Saviano M, Temussi PA, Zanotti G
Ion binding of cyclolinopeptide A: An NMR and CD conformational study (633 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1991 May; 31(6): 761-767.
Impact Factor: 2.425
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Cucinotta V, D'Alessandro F, Impellizzeri G, Pappalardo G, Rizzarelli E, Vecchio G
Cyclopeptide Functionalized beta-Cyclodextrin. A New Class of Potentially Enzyme Mimicking Compound with Two Recognition Sites (267 views)
Chem Commun, 1991; N/D: 293-294.
Impact Factor: 0
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Zanotti G, Tancredi T, Rossi F, Benedetti E, Pedone C, Temussi P
Ala analogues of the cyclolinopeptide (443 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1989 Jan; 28(1): 371-383.
Impact Factor: 2.425
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Tancredi T, Zanotti G, Rossi F, Benedetti E, Pedone C, Temussi PA
Comparison of the conformations of cyclolinopeptide A in the solid state and in solution (423 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1989 Jan; 28(1): 513-523.
Impact Factor: 2.425
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Blasio BD, Rossi F, Benedetti E, Pavone V, Pedone C, Temussi PA, Zanotti G, Tancredi T
Bioactive peptides: Solid-state and solution conformation of cyclolinopeptide (549 views)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 1989; 111(25): 9089-9098.
Impact Factor: 5.65
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Arena G, Impellizzeri G, Maccarrone G, Pappalardo G, Sciotto D, Rizzarelli E
Non-Covalent Interactions in Cyclopeptide Proton Complex Formation in Aqueous Solution (308 views)
Thermochim Acta, 1989; 154: 97-106.
Impact Factor: 0
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85 Records (83 excluding Abstracts).
Total impact factor: 295.175 (291.182 excluding Abstracts).
Total 5 year impact factor: 306.864 (302.197 excluding Abstracts).
Total impact factor: 295.175 (291.182 excluding Abstracts).
Total 5 year impact factor: 306.864 (302.197 excluding Abstracts).
460 views. Last view on Wednesday 01 February 2023, 5:12:44
ibb.cnr.it
