IBB, CNR, Ed.10, Via Panini 5, 80131 Naples, Italy
Department of Biomorphological and Functional Science, University Federico II, Naples, Italy
IBB, CNR, Ed. 10, Via Panini 5, 80131 Naples, Italy
References: Gambhir, S.S., Massoud, T.F., Molecular imaging fundamentals (2004) Nuclear Medicine in Clinical Diagnosis and Treatment, pp. 1845-1870. , Ell P, Gambhir SS, editors. 3rd ed., Edinburgh: Churchill Livingstone Publisher
Phelps, M.E., Inaugural article: Positron emission tomography provides molecular imaging of biological processes (2000) Proc Natl Acad Sci U S a, 97, pp. 9226-9233
Townsend, D.W., Dual-modality imaging: Combining anatomy and function (2008) J Nucl Med, 49, pp. 938-955
Levin, C.S., Hoffman, E.J., Calculation of positron range and its effect on the fundamental limit of positron emission tomography system spatial resolution (1999) Phys Med Biol, 44, pp. 781-799
Muehllehner, G., Karp, J.S., Positron emission tomography (2006) Phys Med Biol, 51, pp. R117-R137
Van Eijk, C.W., Radiation detector developments in medical applications: Inorganic scintillators in positron emission tomography (2008) Radiat Prot Dosimetry, 129, pp. 13-21
Surti, S., Karp, J.S., Popescu, L.M., Daube-Witherspoon, M.E., Werner, M., Investigation of time-of-flight benefit for fully 3-D PET (2006) IEEE Trans Med Imaging, 25, pp. 529-538
Conti, M., Bendriem, B., Casey, M., Chen, M., Kehren, F., Michel, C., Panin, V., First experimental results of time-of-flight reconstruction on an LSO PET scanner (2005) Physics in Medicine and Biology, 50 (19), pp. 4507-4526. , DOI 10.1088/0031-9155/50/19/006
Karp, J.S., Kuhn, A., Perkins, A.E., Surti, S., Werner, M.E., Daube-Witherspoon, M.E., Popescu, L., Muehllehner, G., Characterization of a time-of-flight PET scanner based on lanthanum bromide (2005) IEEE Nuclear Science Symposium Conference Record, 4, pp. 1919-1923. , DOI 10.1109/NSSMIC.2005.1596707, 1596707, 2005 IEEE Nuclear Science Symposium Conference Record -Nuclear Science Symposium and Medical Imaging Conference
Surti, S., Kuhn, A., Werner, M.E., Perkins, A.E., Kolthammer, J., Karp, J.S., Performance of Philips Gemini TF PET/CT scanner with special consideration for its time-of-flight imaging capabilities (2007) Journal of Nuclear Medicine, 48 (3), pp. 471-480. , http://jnm.snmjournals.org/cgi/reprint/48/3/471
Zaidi, H., Montandon, M.-L., The new challenges of brain PET imaging technology (2006) Current Medical Imaging Reviews, 2 (1), pp. 3-13. , http://www.ingentaconnect.com/content/ben/cmir/2006/00000002/00000001/ art00002, DOI 10.2174/157340506775541596
Larobina, M., Brunetti, A., Salvatore, M., Small animal PET: A review of commercially available imaging systems (2006) Current Medical Imaging Reviews, 2 (2), pp. 187-192. , http://www.ingentaconnect.com/content/ben/cmir/2006/00000002/00000002/ art00002, DOI 10.2174/157340506776930610
Wienhard, K., Schmand, M., Casey, M.E., Baker, K., Bao, J., Eriksson, L., The ECAT HRRT performance and first clinical application of the new high resolution research tomograph (2002) IEEE Trans Nucl Sci, 49, pp. 104-110
Wang, Y., Seidel, J., Tsui, B.M.W., Vaquero, J.J., Pomper, M.G., Performance evaluation of the GE healthcare eXplore VISTA dual-ring small-animal PET scanner (2006) Journal of Nuclear Medicine, 47 (11), pp. 1891-1900. , http://jnm.snmjournals.org/cgi/reprint/47/11/1891
Casey, M., (2007) Point Spread Function Reconstruction in PET, , Knoxville (TN): Siemens Molecular Imaging USA, Inc
Herraiz, J.L., Espana, S., Vaquero, J.J., Desco, M., Udias, J.M., FIRST: Fast Iterative Reconstruction Software for (PET) tomography (2006) Physics in Medicine and Biology, 51 (18), pp. 4547-4565. , DOI 10.1088/0031-9155/51/18/007, PII S0031915506176101, 007
Reader, A.J., Zaidi, H., Advances in PET image reconstruction (2007) PET Clin, 2, pp. 173-190
Cherry, S.R., Advances in PET imaging technology (2006) J Nucl Med, 47, pp. 1735-1745
Eriksson, L., Townsend, D., Eriksson, M., Casey, M.E., Schmand, M., Conti, M., Michel, C., Nutt, R., Potential for a fifth generation PET scanner for oncology (2005) IEEE Nuclear Science Symposium Conference Record, 4, pp. 1996-2000. , DOI 10.1109/NSSMIC.2005.1596724, 1596724, 2005 IEEE Nuclear Science Symposium Conference Record -Nuclear Science Symposium and Medical Imaging Conference
Crosetto, D., (2001) Saving Lives Through Early Cancer Detection: Breaking the Current PET Efficiency Barrier with the 3D-CBS, , Presented on May 16, at the University of Geneva, Switzerland
Hoult, D.I., Chen, C.N., Sank, V.J., The field dependence of NMR imaging II. Arguments concerning an optimal field strength (1986) Magn Reson Med, 3, pp. 730-746
Merkle, E.M., Dale, B.M., Abdominal MRI at 3.0 T: The basic revisited (2006) American Journal of Roentgenology, 186 (6), pp. 1524-1532. , DOI 10.2214/AJR.05.0932
Haacke, E.M., Brown, R.W., Thompson, M.R., Venkatesan, R., (1999) Magnetic Resonance Imaging: Physical Principles and Sequence Design, , New York, NY: Wiley
Collins, C.M., Liu, W., Schreiber, W., Yang, Q.X., Smith, M.B., Central brightening due to constructive interference with, without, and despite dielectric resonance (2005) J Magn Reson Imaging, 21, pp. 192-196
Vaughan, J.T., Garwood, M., Collins, C.M., Liu, W., Delabarre, L., Adriany, G., Andersen, P., Ugurbil, K., 7T vs. 4T: RF power, homogeneity, and signal-to-noise comparison in head images (2001) Magnetic Resonance in Medicine, 46 (1), pp. 24-30. , DOI 10.1002/mrm.1156
Tkac, I., Andersen, P., Adriany, G., Merkle, H., Ugurbil, K., Gruetter, R., In vivo 1H NMR spectroscopy of the human brain at 7 T (2001) Magn Reson Med, 46, pp. 451-456
Uurbil, K., Adriany, G., Andersen, P., Chen, W., Garwood, M., Gruetter, R., Ultrahigh field magnetic resonance imaging and spectroscopy (2003) Magn Reson Imaging, 21, pp. 1263-1281
Vaughan, T., Delabarre, L., Snyder, C., Tian, J., Akgun, C., Shrivastava, D., Liu, W., Ugurbil, K., 9.4T human MRI: Preliminary results (2006) Magnetic Resonance in Medicine, 56 (6), pp. 1274-1282. , DOI 10.1002/mrm.21073
Cheng, M.C., Yan, B.P., Lee, K.C., Chan, K.C., Ma, Q.Y., Yang, E.S., A high temperature superconductor tape RF receiver coil for a low field magnetic resonance imaging system Supercond (2005) Sci Technol, 18, pp. 1100-1105
Kwok, W.E., You, Z., In vivo MRI using liquid nitrogen cooled phased array coil at 3.0 T (2006) Magn Reson Imaging, 24, pp. 819-823
Van Den Bergen, B., Van Den Berg, C.A., Bartels, L.W., Lagendijk, J.J., 7 T body MRI: B1 shimming with simultaneous SAR reduction (2007) Phys Med Biol, 52, pp. 5429-5441
Wiesinger, F., Van De Moortele, P.-F., Adriany, G., De Zanche, N., Ugurbil, K., Pruessmann, K.P., Potential and feasibility of parallel MRI at high field (2006) NMR in Biomedicine, 19 (3), pp. 368-378. , DOI 10.1002/nbm.1050
Blamire, A.M., The technology of MRI: The next 10 years? (2008) Br J Radiol, 81, pp. 601-617
Dydak, U., Schär, M., MR spectroscopy and spectroscopic imaging: Comparing 3.0 T versus 1.5 T (2006) Neuroimaging Clin N Am, 16, pp. 269-283. , x
Lin, F.-H., Tsai, S.-Y., Otazo, R., Caprihan, A., Wald, L.L., Belliveau, J.W., Posse, S., Sensitivity-encoded (SENSE) proton echo-planar spectroscopic imaging (PEPSI) in the human brain (2007) Magnetic Resonance in Medicine, 57 (2), pp. 249-257. , DOI 10.1002/mrm.21119
Mansson, S., Johansson, E., Magnusson, P., Chai, C.M., Hansson, G., Petersson, J.S., 13C imaging-a new diagnostic platform (2006) Eur Radiol, 16, pp. 57-67
Mugler III, J.P., Driehuys, B., Brookeman, J.R., Cates, G.D., Berr, S.S., Bryant, R.G., MR imaging and spectroscopy using hyperpolarized 129Xe gas: Preliminary human results (1997) Magn Reson Med, 37, pp. 809-815
Johannesson, H., Axelsson, O., Karlsson, M., Transfer of para-hydrogen spin order into polarization by diabatic field cycling (2004) Comptes Rendus Physique, 5 (3), pp. 315-324. , DOI 10.1016/j.crhy.2004.02.001, PII S1631070504000258
Ardenkjaer-Larsen, J.H., Fridlund, B., Gram, A., Hansson, G., Hansson, L., Lerche, M.H., Servin, R., Golman, K., Increase in signal-to-noise ratio of >
10,000 times in liquid-state NMR (2003) Proceedings of the National Academy of Sciences of the United States of America, 100 (18), pp. 10158-10163. , DOI 10.1073/pnas.1733835100
Kastler, A., Optical methods of atomic orientation and of magnetic resonance (1957) J Opt Soc Am, 47, pp. 460-465
Bouchiat, M.A., Carver, T.R., Varnum, C.M., Nuclear polarization in 3He gas induced byoptical pumping and dipolar exchange (1960) Phys Rev Lett, 5, pp. 373-375
Colegrove, F.D., Schearer, L.D., Walters, G.K., Polarization of He3 gas byoptical pumping (1963) Phys Rev, 132, pp. 2561-2572
Raftery, D., Long, H., Meersmann, T., Grandinetti, P.J., Reven, L., Pines, A., High-?eld NMR of adsorbed xenon polarized by laser pumping (1991) Phys Rev Lett, 66, pp. 584-587
Albert, M.S., Cates, G.D., Driehuys, B., Happer, W., Saam, B., Springer Jr., C.S., Wishnia, A., Biological magnetic resonance imaging using laser-polarized 129Xe (1994) Nature, 370 (6486), pp. 199-201. , DOI 10.1038/370199a0
De Lange, E.E., Mugler III, J.P., Brookeman, J.R., Knight-Scott, J., Truwit, J.D., Teates, C.D., Lung air spaces: MR imaging evaluation with hyperpolarized 3He gas (1999) Radiology, 210, pp. 851-857
Wagshul, M.E., Button, T.M., Li, H.F., Liang, Z., Springer, C.S., Zhong, K., In vivo MR imaging and spectroscopy using hyperpolarized 129Xe (1996) Magn Reson Med, 36, pp. 183-191
Sakai, K., Bilek, A.M., Oteiza, E., Walsworth, R.L., Balamore, D., Jolesz, F.A., Albert, M.S., Temporal dynamics of hyperpolarized129Xe resonances in living rats (1996) Journal of Magnetic Resonance - Series B, 111 (3), pp. 300-304
Maier, T., Driehuys, B., Hinton, D.P., Knight-Scott, J., Mugler III, J.P., Brookeman, J.R., Detection of dissolved hyperpolarized 129Xe in the human brain (1907) Proc Intl Soc Magn Reson Med 6th Meeting 1998
Kilian, W., Seifert, F., Rinneberg, H., Dynamic NMR Spectroscopy of Hyperpolarized129Xe in Human Brain Analyzed by an Uptake Model (2004) Magnetic Resonance in Medicine, 51 (4), pp. 843-847. , DOI 10.1002/mrm.10726
Navon, G., Song, Y.-Q., Room, T., Appelt, S., Taylor, R.E., Pines, A., Enhancement of solution NMR and MRI with laser-polarized xenon (1996) Science, 271 (5257), pp. 1848-1851
Kuhn, L.T., Bommerich, U., Bargon, J., Transfer of parahydrogen-induced hyperpolarization to 19F (2006) J Phys Chem a, 110, pp. 3521-3526
Bowers, C.R., Weitekamp, D.P., Transformation of symmetrization order to nuclear-spin magnetization by chemical reaction and nuclear magnetic resonance (1986) Phys Rev Lett, 57, pp. 2645-2648
Jóhannesson, H., Axelsson, O., Karlsson, M., Goldman, M., Methods to convert para-hydrogen spin order into hetero nuclei polarization for in vivo detection Proc 21st Annual Meeting ESMRMB 2004, p. 144
Sonnewald, U., Gribbestad, I.S., Westergaard, N., Nilsen, G., Unsgard, G., Schousboe, A., Petersen, S.B., Nuclear magnetic resonance spectroscopy: Biochemical evaluation of brain function in vivo and in vitro (1994) NeuroToxicology, 15 (3), pp. 579-590
Schoder, H., Gonen, M., Screening for cancer with PET and PET/CT: Potential and limitations (2007) Journal of Nuclear Medicine, 48 (1 SUPPL.), pp. 4S-18S. , http://jnm.snmjournals.org/cgi/reprint/48/1_suppl/4S
Bartling, S.H., Stiller, W., Semmler, W., Kiessling, F., Small animal computed tomography imaging (2007) Current Medical Imaging Reviews, 3 (1), pp. 45-59. , http://www.ingentaconnect.com/content/ben/cmir/2007/00000003/00000001/ art00006, DOI 10.2174/157340507779940327
Catana, C., Procissi, D., Wu, Y.B., Judenhofer, M.S., Qi, J.Y., Pichler, B.J., Simultaneous in vivo positron emission tomography and magnetic resonance imaging (2008) Proc Nad Acad Sci U S a, 105, pp. 3705-3710
Gambhir, S. S., Massoud, T. F., Molecular imaging fundamentals (2004) Nuclear Medicine in Clinical Diagnosis and Treatment, pp. 1845-1870. , Ell P, Gambhir SS, editors. 3rd ed., Edinburgh: Churchill Livingstone Publisher
Phelps, M. E., Inaugural article: Positron emission tomography provides molecular imaging of biological processes (2000) Proc Natl Acad Sci U S a, 97, pp. 9226-9233
Townsend, D. W., Dual-modality imaging: Combining anatomy and function (2008) J Nucl Med, 49, pp. 938-955
Levin, C. S., Hoffman, E. J., Calculation of positron range and its effect on the fundamental limit of positron emission tomography system spatial resolution (1999) Phys Med Biol, 44, pp. 781-799
Van Eijk, C. W., Radiation detector developments in medical applications: Inorganic scintillators in positron emission tomography (2008) Radiat Prot Dosimetry, 129, pp. 13-21
Karp, J. S., Kuhn, A., Perkins, A. E., Surti, S., Werner, M. E., Daube-Witherspoon, M. E., Popescu, L., Muehllehner, G., Characterization of a time-of-flight PET scanner based on lanthanum bromide (2005) IEEE Nuclear Science Symposium Conference Record, 4, pp. 1919-1923. , DOI 10. 1109/NSSMIC. 2005. 1596707, 1596707, 2005 IEEE Nuclear Science Symposium Conference Record -Nuclear Science Symposium and Medical Imaging Conference
Pichler, B. J., Wehri, H. F., Judenhofer, M. S., Latest advances in molecular imaging instrumentation (2008) J Nucl Med, (49 SUPPL. 2), pp. 5S-23S
Herraiz, J. L., Espana, S., Vaquero, J. J., Desco, M., Udias, J. M., FIRST: Fast Iterative Reconstruction Software for (PET) tomography (2006) Physics in Medicine and Biology, 51 (18), pp. 4547-4565. , DOI 10. 1088/0031-9155/51/18/007, PII S0031915506176101, 007
Reader, A. J., Zaidi, H., Advances in PET image reconstruction (2007) PET Clin, 2, pp. 173-190
Cherry, S. R., Advances in PET imaging technology (2006) J Nucl Med, 47, pp. 1735-1745
Hoult, D. I., Chen, C. N., Sank, V. J., The field dependence of NMR imaging II. Arguments concerning an optimal field strength (1986) Magn Reson Med, 3, pp. 730-746
Merkle, E. M., Dale, B. M., Abdominal MRI at 3. 0 T: The basic revisited (2006) American Journal of Roentgenology, 186 (6), pp. 1524-1532. , DOI 10. 2214/AJR. 05. 0932
Haacke, E. M., Brown, R. W., Thompson, M. R., Venkatesan, R., (1999) Magnetic Resonance Imaging: Physical Principles and Sequence Design, , New York, NY: Wiley
Collins, C. M., Liu, W., Schreiber, W., Yang, Q. X., Smith, M. B., Central brightening due to constructive interference with, without, and despite dielectric resonance (2005) J Magn Reson Imaging, 21, pp. 192-196
Vaughan, J. T., Garwood, M., Collins, C. M., Liu, W., Delabarre, L., Adriany, G., Andersen, P., Ugurbil, K., 7T vs. 4T: RF power, homogeneity, and signal-to-noise comparison in head images (2001) Magnetic Resonance in Medicine, 46 (1), pp. 24-30. , DOI 10. 1002/mrm. 1156
Cheng, M. C., Yan, B. P., Lee, K. C., Chan, K. C., Ma, Q. Y., Yang, E. S., A high temperature superconductor tape RF receiver coil for a low field magnetic resonance imaging system Supercond (2005) Sci Technol, 18, pp. 1100-1105
Kwok, W. E., You, Z., In vivo MRI using liquid nitrogen cooled phased array coil at 3. 0 T (2006) Magn Reson Imaging, 24, pp. 819-823
Blamire, A. M., The technology of MRI: The next 10 years? (2008) Br J Radiol, 81, pp. 601-617
Dydak, U., Sch r, M., MR spectroscopy and spectroscopic imaging: Comparing 3. 0 T versus 1. 5 T (2006) Neuroimaging Clin N Am, 16, pp. 269-283. , x
Lin, F. -H., Tsai, S. -Y., Otazo, R., Caprihan, A., Wald, L. L., Belliveau, J. W., Posse, S., Sensitivity-encoded (SENSE) proton echo-planar spectroscopic imaging (PEPSI) in the human brain (2007) Magnetic Resonance in Medicine, 57 (2), pp. 249-257. , DOI 10. 1002/mrm. 21119
Mugler III, J. P., Driehuys, B., Brookeman, J. R., Cates, G. D., Berr, S. S., Bryant, R. G., MR imaging and spectroscopy using hyperpolarized 129Xe gas: Preliminary human results (1997) Magn Reson Med, 37, pp. 809-815
Bouchiat, M. A., Carver, T. R., Varnum, C. M., Nuclear polarization in 3He gas induced byoptical pumping and dipolar exchange (1960) Phys Rev Lett, 5, pp. 373-375
Colegrove, F. D., Schearer, L. D., Walters, G. K., Polarization of He3 gas byoptical pumping (1963) Phys Rev, 132, pp. 2561-2572
Albert, M. S., Cates, G. D., Driehuys, B., Happer, W., Saam, B., Springer Jr., C. S., Wishnia, A., Biological magnetic resonance imaging using laser-polarized 129Xe (1994) Nature, 370 (6486), pp. 199-201. , DOI 10. 1038/370199a0
De Lange, E. E., Mugler III, J. P., Brookeman, J. R., Knight-Scott, J., Truwit, J. D., Teates, C. D., Lung air spaces: MR imaging evaluation with hyperpolarized 3He gas (1999) Radiology, 210, pp. 851-857
Wagshul, M. E., Button, T. M., Li, H. F., Liang, Z., Springer, C. S., Zhong, K., In vivo MR imaging and spectroscopy using hyperpolarized 129Xe (1996) Magn Reson Med, 36, pp. 183-191
Kuhn, L. T., Bommerich, U., Bargon, J., Transfer of parahydrogen-induced hyperpolarization to 19F (2006) J Phys Chem a, 110, pp. 3521-3526
Bowers, C. R., Weitekamp, D. P., Transformation of symmetrization order to nuclear-spin magnetization by chemical reaction and nuclear magnetic resonance (1986) Phys Rev Lett, 57, pp. 2645-2648
J hannesson, H., Axelsson, O., Karlsson, M., Goldman, M., Methods to convert para-hydrogen spin order into hetero nuclei polarization for in vivo detection Proc 21st Annual Meeting ESMRMB 2004, p. 144
Bartling, S. H., Stiller, W., Semmler, W., Kiessling, F., Small animal computed tomography imaging (2007) Current Medical Imaging Reviews, 3 (1), pp. 45-59. , http: //www. ingentaconnect. com/content/ben/cmir/2007/00000003/00000001/ art00006, DOI 10. 2174/157340507779940327
Technological platforms for molecular imaging: A vision of the future
"In vivo" imaging is a tool able to conduct studies on living subjects over time and hence of great importance in pre-clinical research, clinical trials and clinical practice. Investigation of the molecular basis of disease through the study of biological processes involved in the onset and in the progression of pathology is mainly conducted with research on laboratory animals. A fundamental improvement in our understanding of diseases will result by the application of the new molecular imaging tools to humans. The technological evolution plays an important role in this field through the development of instrumentation able to depict the temporal and the spatial distribution of molecular probes with enough resolution and sensitivity. This article highlights recent advances in technological platforms for molecular imaging with an emphasis on tomographic systems that use positron-emitting radionuclides (PET), magnetic fields (MRI) and X-ray (CT). Current and possible future imaging systems, both clinical and pre-clinical, including combined systems, will be discussed.
Technological platforms for molecular imaging: A vision of the future
Antonini A, Vitale C, Barone P, Cilia R, Righini A, Bonuccelli U, Abbruzzese G, Ramat S, Petrone A, Quatrale R, Marconi R, Ceravolo R, Stefani A, Lopiano L, Zappia M, Capus L, Morgante L, Tamma F, Tinazzi M, Colosimo C, Guerra UP, Valzania F, Fagioli G, Distefano A, Bagnato A, Feggi L, Anna S, Maria Teresa Rosaria De Cr, Nobili F, Mazzuca N, Baldari S, Eleopra R, Bestetti A, Benti R, Varrone A, Volterrani D, Massa R, Stocchi F, Schillaci O, Dore F, Zibetti M, Castellano G, Battista SG, Giorgetti G * The relationship between cerebral vascular disease and parkinsonism: The VADO study(495 views) Parkinsonism Relat D (ISSN: 1353-8020, 1873-5126, 1873-5126electronic), 2012; 18(6): 775-780. Impact Factor:3.274 ViewExport to BibTeXExport to EndNote
Bruni AC, Bernardi L, Colao R, Rubino E, Smirne N, Frangipane F, Terni B, Curcio SA, Mirabelli M, Clodomiro A, Di Lorenzo R, Maletta R, Anfossi M, Gallo M, Geracitano S, Tomaino C, Muraca MG, Leotta A, Lio SG, Pinessi L, Rainero I, Sorbi S, Nee L, Milan G, Pappata S, Postiglione A, Abbamondi N, Forloni G, St George Hyslop P, Rogaeva E, Bugiani O, Giaccone G, Foncin JF, Spillantini MG, Puccio G * Worldwide distribution of PSEN1 Met146Leu mutation: A large variability for a founder mutation(761 views) Neurology (ISSN: 0028-3878, 1526-632x, 1526-632xelectronic), 2010 Mar 9; 74(10): 798-806. Impact Factor:8.017 ViewExport to BibTeXExport to EndNote
Ntziachristos V, Cuénod CA, Fournier L, Balvay D, Pradel C, Siauve N, Clement O, Jouannot E, Lucidarme O, Vecchio SD, Salvatore M, Law B, Tung C-H, Jain RK, Fukumura D, Munn LL, Brown EB, Schellenberger E, Montet X, Weissleder R, Clerck ND, Postnov A * Tumor Imaging(350 views) Textbook Of In Vivo Imaging In Vertebrates (ISSN: 9780-4700), 2007 Jul 16; 1: 277-309. Impact Factor:1.148 ViewExport to BibTeXExport to EndNote
Hesse B, Tagil K, Cuocolo A, Anagnostopoulos C, Bardies M, Bax J, Bengel F, Busemann Sokole E, Davies G, Dondi M, Edenbrandt L, Franken P, Kjaer A, Knuuti J, Lassmann M, Ljungberg M, Marcassa C, Marie PY, Mckiddie F, O'connor M, Prvuolovich E, Underwood R * 3. 0 T perfusion MR imaging(692 views) Rivista Di Neuroradiologia (ISSN: 1120-9976), 2004; 17(6): 807-812. Impact Factor:0.023 ViewExport to BibTeXExport to EndNote