Keywords: Antiepileptic, Brain Isoforms, Carbonic Anhydrase, Enzyme Inhibitor, Zonisamide, Anticonvulsive Agent, Carbonate Dehydratase, Carbonate Dehydratase Ii, Carbonate Dehydratase Vii, Carbonate Dehydratase Xii, Sulfamic Acid, Sulfonamide, Sultiame, Topiramate, Unclassified Drug, Article, Central Nervous System, Correlation Analysis, Drug Activity, Drug Design, Drug Structure, Enzyme Inhibition, Human, Mammal, Nonhuman, Priority Journal, Animals, Anticonvulsants, Carbonic Anhydrase Inhibitors, Protein Isoforms, Recombinant Proteins, Sulfonic Acids,
Affiliations: *** IBB - CNR ***
Istituto di Biostrutture e Bioimmagini, CNR, via Mezzocannone 16, 80134 Napoli, Italy
Università degli Studi di Firenze, Polo Scientifico, Laboratorio di Chimica Bioinorganica, Via della Lastruccia 3, 50019 Sesto Fiorentino (Florence), Italy
Universit degli Studi di Firenze, Polo Scientifico, Laboratorio di Chimica Bioinorganica, Via della Lastruccia 3, 50019 Sesto Fiorentino (Florence), Italy
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Hilvo, M., Innocenti, A., Montim, S.M., De Simone, G., Supuran, C.T., Parkkila, S., Recent advances in research on the most novel carbonic anhydrases, CA XIII and XV (2008) Curr Pharm des, 14, pp. 672-678
Parkkila, S., Significance of pH regulation and carbonic anhydrases in tumour progression and implications for diagnostic and therapeutic approaches (2008) BJU Int, 101 (SUPPL. 4), pp. 16-21
Pastorekova, S., Ratcliffe, P.J., Pastorek, J., Molecular mechanisms of carbonic anhydrase IX-mediated pH regulation under hypoxia (2008) BJU Int, 101 (SUPPL. 4), pp. 8-15
De Simone, G., Di Fiore, A., Menchise, V., Pedone, C., Antel, J., Casini, A., Scozzafava, A., Supuran, C.T., Carbonic anhydrase inhibitors. Zonisamide is an effective inhibitor of the cytosolic isozyme II and mitochondrial isozyme V: Solution and X-ray crystallographic studies (2005) Bioorg Med Chem Lett, 15, pp. 2315-2320
Thöne, J., Leniger, T., Splettstösser, F., Wiemann, M., Antiepileptic activity of zonisamide on hippocampal CA3 neurons does not depend on carbonic anhydrase inhibition (2008) Epilepsy Res, 79, pp. 105-111
Ilies, M.A., Masereel, B., Rolin, S., Scozzafava, A., Campeanu, G., Cimpeanu, V., Supuran, C.T., Carbonic anhydrase inhibitors: Aromatic and heterocyclic sulfonamides incorporating adamantyl moieties with strong anticonvulsant activity (2004) Bioorg Med Chem, 12, pp. 2717-2726
Thiry, A., Dogné, J.M., Supuran, C.T., Masereel, B., Anticonvulsant sulfonamides/sulfamates/ sulfamides with carbonic anhydrase inhibitory activity: Drug design and mechanism of action (2008) Curr Pharm des, 14, pp. 661-671
Ruusuvuori, E., Li, H., Huttu, K., Palva, J.M., Smirnov, S., Rivera, C., Kaila, K., Voipio, J., Carbonic anhydrase isoform VII acts as a molecular switch in the development of synchronous gamma-frequency firing of hippocampal CA1 pyramidal cells (2004) J Neurosci, 24, pp. 2699-2707
Nishimori, I., Acatalytic CAs: Carbonic anhydrase related proteins (2004) Carbonic Anhydrase - Its Inhibitors and Activators., pp. 25-43. , Supuran, C.T. Scozzafava, A. Conway, J. editors. Boca Raton (FL): CRC Press
Parkkila, S., Parkkila, A.K., Rajaniemi, H., Shah, G.N., Grubb, J.H., Waheed, A., Sly, W.S., Expression of membrane-associated carbonic anhydrase XIV on neurons and axons in mouse and human brain (2001) Proc Natl Acad Sci U S a, 98, pp. 1918-1923
Casini, A., Antel, J., Abbate, F., Scozzafava, A., David, S., Waldeck, H., Schäfer, S., Supuran, C.T., Carbonic anhydrase inhibitors: SAR and X-ray crystallographic study for the interaction of sugar sulfamates/sulfamides with isozymes I, II and IV (2003) Bioorg Med Chem Lett, 13, pp. 841-845
Temperini, C., Innocenti, A., Mastrolorenzo, A., Scozzafava, A., Supuran, C.T., Carbonic anhydrase inhibitors. Interaction of the antiepileptic drug sulthiame with twelve mammalian isoforms: Kinetic and X-ray crystallographic studies (2007) Bioorg Med Chem Lett, 17, pp. 4866-4872
Khalifah, R.G., The carbon dioxide hydration activity of carbonic anhydrase (1971) J Biol Chem, 246, pp. 2561-2573
Supuran, C. T., Carbonic anhydrases: Novel therapeutic applications for inhibitors and activators (2008) Nat Rev Drug Discov, 7, pp. 168-18
Th ne, J., Leniger, T., Splettst sser, F., Wiemann, M., Antiepileptic activity of zonisamide on hippocampal CA3 neurons does not depend on carbonic anhydrase inhibition (2008) Epilepsy Res, 79, pp. 105-111
Ilies, M. A., Masereel, B., Rolin, S., Scozzafava, A., Campeanu, G., Cimpeanu, V., Supuran, C. T., Carbonic anhydrase inhibitors: Aromatic and heterocyclic sulfonamides incorporating adamantyl moieties with strong anticonvulsant activity (2004) Bioorg Med Chem, 12, pp. 2717-2726
Thiry, A., Dogn, J. M., Supuran, C. T., Masereel, B., Anticonvulsant sulfonamides/sulfamates/ sulfamides with carbonic anhydrase inhibitory activity: Drug design and mechanism of action (2008) Curr Pharm des, 14, pp. 661-671
Khalifah, R. G., The carbon dioxide hydration activity of carbonic anhydrase (1971) J Biol Chem, 246, pp. 2561-2573
Which Carbonic Anhydrases are Targeted by the Antiepileptic Sulfonamides and Sulfamates?