Micelles derivatized with octreotide as potential target-selective contrast agents in MRI (417 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 242-250.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 1.807, 5-year impact factor: 1.872
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-63449132697&partnerID=40&md5=96d23947eb6096e65d2ffb3e1ec9f7e7
Keywords: Fluorescence Spectroscopy And Circular Dichroism, Micelles, Mri Contrast Agent, Octreotide, Nuclear Magnetic Resonance Imaging Agent, 10 Tetraazacyclododecane 1, 10 Tetraacetic Acid, 10 Tetraacetic Acid Gadolinium, Octreotide Pentetic Acid Glutamate, Octreotide Pentetic Acid Glutamate Gadolinium, Unclassified Drug, Contrast Medium, Article, Beta Sheet, Derivatization, Drug Design, Drug Structure, Drug Synthesis, Priority Journal, Solid Phase Synthesis, Chemical Structure, Chemistry, Methodology, Oxalis Tuberosa, Molecular Structure,
Affiliations:
*** IBB - CNR ***
Department of Biological Sciences, CIRPeB, University of Naples Federico II and IBB CNR, Via Mezzocannone 16, 80134 Naples, Italy
Department of Chemistry I.F.M., Molecular Imaging Centre, University of Turin, Via Nizza 52, 10125 Turin, Italy
References:
Brazeau, P., Vale, W., Burgus, R., Ling, N., Butcher, M., Rivier, J., Guillemin, R., Hypothalamic polypeptide that inhibits the secretion of immunoreactive pituitary growth hormone (1973) Science, 179, pp. 77-7
Bell, G., Reisine, T., Molecular biology of somatostatin receptors (1993) Trends Neurosci, 16, pp. 34-38
Reubi, J.C., Horisberger, U., Laissue, J., High density of somatostatin receptors in veins surrounding human cancer tissue: Role in tumour host interaction? (1994) Int. J. Cancer, 56, pp. 681-688
Reubi, J.C., Schaer, J.C., Waser, B., Mengod, G., Expression and localization of somatostatin receptor SSTR1, SSTR2, and SSTR3 messenger RNAs in primary human tumors using in situ hybridization (1994) Cancer Res, 54, pp. 3455-3459
Patel, Y.C., Wheatley, T., In vivo and in vitro plasma disappearance of somatostatin-14 and somatostatin-28 in the rat (1983) Endocrinology, 112, pp. 220-225
Lamberts, S.W.J., Octreotide: The Next Decade (1999) BioScientifica, , Bristol
Bauer, W., Briner, U., Doepfner, W., SMS 201-995: A very potent and selective octapeptide analogue of somatostatin with prolonged action (1982) Life Sci, 31, pp. 1133-1140
Veber, D.F., Freidinger, R.M., Schwenk-Perlow, D., Paleveda Jr, W.J., Holly, F.W., Strachan, R.G., Nurr, R.F., Hirschmann, R., A potent cyclic hexapeptide analogue of somatostatin (1981) Nature, 292, pp. 55-58
Patel, C.Y., Somatostatin and its receptor family (1999) Front. Neuroendocrinol. Rev, 20, pp. 157-198
Hofland, L.J., Internalization of [DOTA,125I-Tyr3]octreotide by somatostatin receptor-positive cells in vitro and in vivo: Implications for somatostatin receptor-targeted radio-guided surgery (1999) Proc.Assoc. Am. Phys, 111, pp. 63-69
Huang, C.M., Wu, Y.T., Chen, S.T., Targeting delivery of paclitaxel into tumor cells via somatostatin receptor endocytosis (2000) Chem. Biol, 7, pp. 453-461
Mier, W., Eritja, R., Ashour, M., Haberkorn, U., Eisenhut, M., Peptide-PNA conjugates targeted transport of antisense therapeutics into tumours (2003) Angew. Chem., Int. Ed. Engl, 42, pp. 1968-1971
Lamberts, S.W.J., Krenning, E.P., Reubi, J.C., The role of somatostatin and its analogs in the diagnosis and treatment of tumors (1991) Endocrinol. Rev, 12, pp. 450-482
Krenning, E.P., Kwekkeboom, D.J., Pauwels, S., Kvols, L.K., Reubi, J.C., Somatostatin receptor scintigraphy (1995) Nucl. Med. Annu, pp. 1-50
Reubi JC, Waser B, Schaer JC, Laissue JA. Somatostatin receptor sst1-sst5 expression in normal and neoplastic human tissues using receptor autoradiography with subtype-selective ligands. Eur. J. Nucl. Med. 2001
28: 836-846, Erratum in Eur. J. Nucl. Med. 2001
28: 1433Froidevaux, S., Eberle, A.N., Somatostatin analogues and radiopeptides in cancer therapy (2002) Biopolymers (Pept. Sci.), 66, pp. 161-183
Andre, J.P., Toth, E., Fischer, H., Seelig, A., Maecke, H.R., Merbach, A.E., High relaxivity for monomeric Gd(DOTA)-Based MRI contrast agents, thanks to micellar self-organization (1999) Chem. - Eur. J, 5, pp. 2977-2983
Gløgård, C., Stensrud, G., Hovland, R., Fossheim, S.L., Klaveness, J., Liposomes as carriers of amphiphilic gadolinium chelates: The affect of membrane composition on incorporation efficacy and in vitro relaxivity (2002) Int. J. Pharm, 233, pp. 131-140
Mulder, W.J.M., Strijkers, G.J., Griffioen, A.W., Van Bloois, L., Molema, G., Storm, G., Koning, A., Nicolay, K., A liposomal system for contrast-enhanced magnetic resonance imaging of molecular targets (2004) Bioconjugate Chem, 15, pp. 799-806
Accardo, A., Tesauro, D., Roscigno, P., Gianolio, E., Paduano, L., D'Errico, G., Pedone, C., Morelli, G., Physicochemical properties of mixed micellar aggregates containing CCK peptides and Gd complexes designed as tumor specific contrast agents in MRI (2004) J. Am. Chem. Soc, 126, pp. 3097-3107
Vaccaro, M., Mangiapia, G., Paduano, L., Gianolio, E., Accardo, A., Tesauro, D., Morelli, G., Structural and relaxometric Characterization peptide aggregates containing gadolinium complexes as potential selective contrastagents in MRI (2007) ChemPhysChem, 8, pp. 2526-2538
Wang, Q., Graham, K., Schauer, T., Fietz, T., Mohammed, A., Liu, X., Hoffend, J., Mier, W., Pharmacological properties of hydrophilic and lipophilic derivatives of octreotate (2004) Nucl. Med. Biol, 31, pp. 21-30
Torchilin, V.P., Omelyanenko, V.G., Papisov, M.I., Bogdanov, A.J., Trubetskoy, V.S., Herron, J.N., Gentry, C.A., Poly(ethylene glycol) on the liposome surface: On the mechanism of polymer-coated liposome longevity (1994) Biochim. Biophys. Acta, 119, pp. 11-20
Chang, W.C., White, P.D., (2000) Fmoc Solid Phase Peptide Synthesis, , Oxford University Press: New York,USA
Birdi, K.S., Singh, H.N., Dalsager, S.U., Interaction of ionic micelles with the hydrophobic fluorescent probe 1-anilino-8-naphthalenesulfonate (1979) J. Phys. Chem, 83, pp. 2733-2737
Morag, O., Ahmad, A., Kamaly, N., Perouzel, E., Caussin, A., Keller, M., Herlihy, A., Jorgensen, M.R., MAGfect: A novel liposome formulation for MRI labelling and visualization of cells (2006) Org. Biomol. Chem, 4, pp. 3489-3497
Wynants, C., Van Binst, G., Loosli, H.R., SMS 201-995, a very potent analogue of somatostatin. Assignment of the 1H 500 MHz NMR spectra and conformational analysis in aqueous solution (1985) Int. J. Pept. Protein Res, 25, pp. 608-614
Pohl, E., Heine, A., Sheldrick, G.M., Dauter, Z., Wilson, K.S., Kallen, J., Huber, W., Pfaefli, P.J., Structure of octreotide, a somatostatin analogue (1995) Acta Crystallogr, D51, pp. 48-59
Lackowicz, J.R., (1983) Principles of Fluorescence Spectroscopy, , Plenum Press: New York
Caravan, P., Ellison, J.J., McMurry, T.J., Lauffer, R.B., Gadolinium(III) chelates as MRI contrast agents: Structure, dynamics and applications (1999) Chem. Rev. (Washington, DC), 99, pp. 2293-2352
Bloembergen, N., Morgan, L.O., Proton relaxation times in paramagnetic solutions. Effects of electron spin relaxation (1961) J. Chem. Phys, 34, pp. 842-850
Lipari, G., Szabo, A., Model-free approach to the interpretation of nuclear magnetic resonance relaxation in macromolecules. 1. Theory and range of validity (1982) J. Am. Chem. Soc, 104, pp. 4546-4559
Anelli, P.L., Fedeli, F., Gazzotti, O., Lattuada, L., Lux, G., Rebasti, F., L-glutamic acid and L-Lysine as Useful Building Blocks for the Preparation of Bifunctional DTPA-like Ligands (1999) Bioconjugate Chem, 10, pp. 137-140
Schmitt, L., Dietrich, C., Synthesis and characterization of chelator-lipids for reversible immobilization of engineered proteins at self-assembled lipid interfaces (1994) J. Am. Chem. Soc, 116, pp. 8485-8491
Ellmann, G.L., Tissue sulfhydryl groups (1959) Arch. Biochem. Biophys, 82, pp. 70-77
Edelhoch, H., Spectroscopic determination of tryptophan and tyrosine in proteins (1967) Biochemistry, 6, pp. 1948-1954
Pace, C.N., Vajdos, F., Fee, L., Grimsley, G., Gray, T., How to measure and predict the molar absorption coefficient of a protein (1995) Protein Sci, 4, pp. 2411-2423
De Vendittis, E., Palumbo, G., Parlato, G., Bocchini, V., A fluorimetric method for the estimation of the critical micelle concentration of surfactants (1981) Anal. Biochem, 115, pp. 278-286
Reubi, J. C., Horisberger, U., Laissue, J., High density of somatostatin receptors in veins surrounding human cancer tissue: Role in tumour host interaction? (1994) Int. J. Cancer, 56, pp. 681-688
Reubi, J. C., Schaer, J. C., Waser, B., Mengod, G., Expression and localization of somatostatin receptor SSTR1, SSTR2, and SSTR3 messenger RNAs in primary human tumors using in situ hybridization (1994) Cancer Res, 54, pp. 3455-3459
Patel, Y. C., Wheatley, T., In vivo and in vitro plasma disappearance of somatostatin-14 and somatostatin-28 in the rat (1983) Endocrinology, 112, pp. 220-225
Lamberts, S. W. J., Octreotide: The Next Decade (1999) BioScientifica, , Bristol
Veber, D. F., Freidinger, R. M., Schwenk-Perlow, D., Paleveda Jr, W. J., Holly, F. W., Strachan, R. G., Nurr, R. F., Hirschmann, R., A potent cyclic hexapeptide analogue of somatostatin (1981) Nature, 292, pp. 55-58
Patel, C. Y., Somatostatin and its receptor family (1999) Front. Neuroendocrinol. Rev, 20, pp. 157-198
Hofland, L. J., Internalization of [DOTA, 125I-Tyr3] octreotide by somatostatin receptor-positive cells in vitro and in vivo: Implications for somatostatin receptor-targeted radio-guided surgery (1999) Proc. Assoc. Am. Phys, 111, pp. 63-69
Huang, C. M., Wu, Y. T., Chen, S. T., Targeting delivery of paclitaxel into tumor cells via somatostatin receptor endocytosis (2000) Chem. Biol, 7, pp. 453-461
Krenning, E. P., Kwekkeboom, D. J., Pauwels, S., Kvols, L. K., Reubi, J. C., Somatostatin receptor scintigraphy (1995) Nucl. Med. Annu, pp. 1-50
Andre, J. P., Toth, E., Fischer, H., Seelig, A., Maecke, H. R., Merbach, A. E., High relaxivity for monomeric Gd (DOTA) -Based MRI contrast agents, thanks to micellar self-organization (1999) Chem. - Eur. J, 5, pp. 2977-2983
Gl g rd, C., Stensrud, G., Hovland, R., Fossheim, S. L., Klaveness, J., Liposomes as carriers of amphiphilic gadolinium chelates: The affect of membrane composition on incorporation efficacy and in vitro relaxivity (2002) Int. J. Pharm, 233, pp. 131-140
Mulder, W. J. M., Strijkers, G. J., Griffioen, A. W., Van Bloois, L., Molema, G., Storm, G., Koning, A., Nicolay, K., A liposomal system for contrast-enhanced magnetic resonance imaging of molecular targets (2004) Bioconjugate Chem, 15, pp. 799-806
Torchilin, V. P., Omelyanenko, V. G., Papisov, M. I., Bogdanov, A. J., Trubetskoy, V. S., Herron, J. N., Gentry, C. A., Poly (ethylene glycol) on the liposome surface: On the mechanism of polymer-coated liposome longevity (1994) Biochim. Biophys. Acta, 119, pp. 11-20
Chang, W. C., White, P. D., (2000) Fmoc Solid Phase Peptide Synthesis, , Oxford University Press: New York, USA
Birdi, K. S., Singh, H. N., Dalsager, S. U., Interaction of ionic micelles with the hydrophobic fluorescent probe 1-anilino-8-naphthalenesulfonate (1979) J. Phys. Chem, 83, pp. 2733-2737
Lackowicz, J. R., (1983) Principles of Fluorescence Spectroscopy, , Plenum Press: New York
Anelli, P. L., Fedeli, F., Gazzotti, O., Lattuada, L., Lux, G., Rebasti, F., L-glutamic acid and L-Lysine as Useful Building Blocks for the Preparation of Bifunctional DTPA-like Ligands (1999) Bioconjugate Chem, 10, pp. 137-140
Ellmann, G. L., Tissue sulfhydryl groups (1959) Arch. Biochem. Biophys, 82, pp. 70-77
Pace, C. N., Vajdos, F., Fee, L., Grimsley, G., Gray, T., How to measure and predict the molar absorption coefficient of a protein (1995) Protein Sci, 4, pp. 2411-2423
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 242-250.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 1.807, 5-year impact factor: 1.872
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-63449132697&partnerID=40&md5=96d23947eb6096e65d2ffb3e1ec9f7e7
Keywords: Fluorescence Spectroscopy And Circular Dichroism, Micelles, Mri Contrast Agent, Octreotide, Nuclear Magnetic Resonance Imaging Agent, 10 Tetraazacyclododecane 1, 10 Tetraacetic Acid, 10 Tetraacetic Acid Gadolinium, Octreotide Pentetic Acid Glutamate, Octreotide Pentetic Acid Glutamate Gadolinium, Unclassified Drug, Contrast Medium, Article, Beta Sheet, Derivatization, Drug Design, Drug Structure, Drug Synthesis, Priority Journal, Solid Phase Synthesis, Chemical Structure, Chemistry, Methodology, Oxalis Tuberosa, Molecular Structure,
Affiliations:
*** IBB - CNR ***
Department of Biological Sciences, CIRPeB, University of Naples Federico II and IBB CNR, Via Mezzocannone 16, 80134 Naples, Italy
Department of Chemistry I.F.M., Molecular Imaging Centre, University of Turin, Via Nizza 52, 10125 Turin, Italy
References:
Brazeau, P., Vale, W., Burgus, R., Ling, N., Butcher, M., Rivier, J., Guillemin, R., Hypothalamic polypeptide that inhibits the secretion of immunoreactive pituitary growth hormone (1973) Science, 179, pp. 77-7
Bell, G., Reisine, T., Molecular biology of somatostatin receptors (1993) Trends Neurosci, 16, pp. 34-38
Reubi, J.C., Horisberger, U., Laissue, J., High density of somatostatin receptors in veins surrounding human cancer tissue: Role in tumour host interaction? (1994) Int. J. Cancer, 56, pp. 681-688
Reubi, J.C., Schaer, J.C., Waser, B., Mengod, G., Expression and localization of somatostatin receptor SSTR1, SSTR2, and SSTR3 messenger RNAs in primary human tumors using in situ hybridization (1994) Cancer Res, 54, pp. 3455-3459
Patel, Y.C., Wheatley, T., In vivo and in vitro plasma disappearance of somatostatin-14 and somatostatin-28 in the rat (1983) Endocrinology, 112, pp. 220-225
Lamberts, S.W.J., Octreotide: The Next Decade (1999) BioScientifica, , Bristol
Bauer, W., Briner, U., Doepfner, W., SMS 201-995: A very potent and selective octapeptide analogue of somatostatin with prolonged action (1982) Life Sci, 31, pp. 1133-1140
Veber, D.F., Freidinger, R.M., Schwenk-Perlow, D., Paleveda Jr, W.J., Holly, F.W., Strachan, R.G., Nurr, R.F., Hirschmann, R., A potent cyclic hexapeptide analogue of somatostatin (1981) Nature, 292, pp. 55-58
Patel, C.Y., Somatostatin and its receptor family (1999) Front. Neuroendocrinol. Rev, 20, pp. 157-198
Hofland, L.J., Internalization of [DOTA,125I-Tyr3]octreotide by somatostatin receptor-positive cells in vitro and in vivo: Implications for somatostatin receptor-targeted radio-guided surgery (1999) Proc.Assoc. Am. Phys, 111, pp. 63-69
Huang, C.M., Wu, Y.T., Chen, S.T., Targeting delivery of paclitaxel into tumor cells via somatostatin receptor endocytosis (2000) Chem. Biol, 7, pp. 453-461
Mier, W., Eritja, R., Ashour, M., Haberkorn, U., Eisenhut, M., Peptide-PNA conjugates targeted transport of antisense therapeutics into tumours (2003) Angew. Chem., Int. Ed. Engl, 42, pp. 1968-1971
Lamberts, S.W.J., Krenning, E.P., Reubi, J.C., The role of somatostatin and its analogs in the diagnosis and treatment of tumors (1991) Endocrinol. Rev, 12, pp. 450-482
Krenning, E.P., Kwekkeboom, D.J., Pauwels, S., Kvols, L.K., Reubi, J.C., Somatostatin receptor scintigraphy (1995) Nucl. Med. Annu, pp. 1-50
Reubi JC, Waser B, Schaer JC, Laissue JA. Somatostatin receptor sst1-sst5 expression in normal and neoplastic human tissues using receptor autoradiography with subtype-selective ligands. Eur. J. Nucl. Med. 2001
28: 836-846, Erratum in Eur. J. Nucl. Med. 2001
28: 1433Froidevaux, S., Eberle, A.N., Somatostatin analogues and radiopeptides in cancer therapy (2002) Biopolymers (Pept. Sci.), 66, pp. 161-183
Andre, J.P., Toth, E., Fischer, H., Seelig, A., Maecke, H.R., Merbach, A.E., High relaxivity for monomeric Gd(DOTA)-Based MRI contrast agents, thanks to micellar self-organization (1999) Chem. - Eur. J, 5, pp. 2977-2983
Gløgård, C., Stensrud, G., Hovland, R., Fossheim, S.L., Klaveness, J., Liposomes as carriers of amphiphilic gadolinium chelates: The affect of membrane composition on incorporation efficacy and in vitro relaxivity (2002) Int. J. Pharm, 233, pp. 131-140
Mulder, W.J.M., Strijkers, G.J., Griffioen, A.W., Van Bloois, L., Molema, G., Storm, G., Koning, A., Nicolay, K., A liposomal system for contrast-enhanced magnetic resonance imaging of molecular targets (2004) Bioconjugate Chem, 15, pp. 799-806
Accardo, A., Tesauro, D., Roscigno, P., Gianolio, E., Paduano, L., D'Errico, G., Pedone, C., Morelli, G., Physicochemical properties of mixed micellar aggregates containing CCK peptides and Gd complexes designed as tumor specific contrast agents in MRI (2004) J. Am. Chem. Soc, 126, pp. 3097-3107
Vaccaro, M., Mangiapia, G., Paduano, L., Gianolio, E., Accardo, A., Tesauro, D., Morelli, G., Structural and relaxometric Characterization peptide aggregates containing gadolinium complexes as potential selective contrastagents in MRI (2007) ChemPhysChem, 8, pp. 2526-2538
Wang, Q., Graham, K., Schauer, T., Fietz, T., Mohammed, A., Liu, X., Hoffend, J., Mier, W., Pharmacological properties of hydrophilic and lipophilic derivatives of octreotate (2004) Nucl. Med. Biol, 31, pp. 21-30
Torchilin, V.P., Omelyanenko, V.G., Papisov, M.I., Bogdanov, A.J., Trubetskoy, V.S., Herron, J.N., Gentry, C.A., Poly(ethylene glycol) on the liposome surface: On the mechanism of polymer-coated liposome longevity (1994) Biochim. Biophys. Acta, 119, pp. 11-20
Chang, W.C., White, P.D., (2000) Fmoc Solid Phase Peptide Synthesis, , Oxford University Press: New York,USA
Birdi, K.S., Singh, H.N., Dalsager, S.U., Interaction of ionic micelles with the hydrophobic fluorescent probe 1-anilino-8-naphthalenesulfonate (1979) J. Phys. Chem, 83, pp. 2733-2737
Morag, O., Ahmad, A., Kamaly, N., Perouzel, E., Caussin, A., Keller, M., Herlihy, A., Jorgensen, M.R., MAGfect: A novel liposome formulation for MRI labelling and visualization of cells (2006) Org. Biomol. Chem, 4, pp. 3489-3497
Wynants, C., Van Binst, G., Loosli, H.R., SMS 201-995, a very potent analogue of somatostatin. Assignment of the 1H 500 MHz NMR spectra and conformational analysis in aqueous solution (1985) Int. J. Pept. Protein Res, 25, pp. 608-614
Pohl, E., Heine, A., Sheldrick, G.M., Dauter, Z., Wilson, K.S., Kallen, J., Huber, W., Pfaefli, P.J., Structure of octreotide, a somatostatin analogue (1995) Acta Crystallogr, D51, pp. 48-59
Lackowicz, J.R., (1983) Principles of Fluorescence Spectroscopy, , Plenum Press: New York
Caravan, P., Ellison, J.J., McMurry, T.J., Lauffer, R.B., Gadolinium(III) chelates as MRI contrast agents: Structure, dynamics and applications (1999) Chem. Rev. (Washington, DC), 99, pp. 2293-2352
Bloembergen, N., Morgan, L.O., Proton relaxation times in paramagnetic solutions. Effects of electron spin relaxation (1961) J. Chem. Phys, 34, pp. 842-850
Lipari, G., Szabo, A., Model-free approach to the interpretation of nuclear magnetic resonance relaxation in macromolecules. 1. Theory and range of validity (1982) J. Am. Chem. Soc, 104, pp. 4546-4559
Anelli, P.L., Fedeli, F., Gazzotti, O., Lattuada, L., Lux, G., Rebasti, F., L-glutamic acid and L-Lysine as Useful Building Blocks for the Preparation of Bifunctional DTPA-like Ligands (1999) Bioconjugate Chem, 10, pp. 137-140
Schmitt, L., Dietrich, C., Synthesis and characterization of chelator-lipids for reversible immobilization of engineered proteins at self-assembled lipid interfaces (1994) J. Am. Chem. Soc, 116, pp. 8485-8491
Ellmann, G.L., Tissue sulfhydryl groups (1959) Arch. Biochem. Biophys, 82, pp. 70-77
Edelhoch, H., Spectroscopic determination of tryptophan and tyrosine in proteins (1967) Biochemistry, 6, pp. 1948-1954
Pace, C.N., Vajdos, F., Fee, L., Grimsley, G., Gray, T., How to measure and predict the molar absorption coefficient of a protein (1995) Protein Sci, 4, pp. 2411-2423
De Vendittis, E., Palumbo, G., Parlato, G., Bocchini, V., A fluorimetric method for the estimation of the critical micelle concentration of surfactants (1981) Anal. Biochem, 115, pp. 278-286
Reubi, J. C., Horisberger, U., Laissue, J., High density of somatostatin receptors in veins surrounding human cancer tissue: Role in tumour host interaction? (1994) Int. J. Cancer, 56, pp. 681-688
Reubi, J. C., Schaer, J. C., Waser, B., Mengod, G., Expression and localization of somatostatin receptor SSTR1, SSTR2, and SSTR3 messenger RNAs in primary human tumors using in situ hybridization (1994) Cancer Res, 54, pp. 3455-3459
Patel, Y. C., Wheatley, T., In vivo and in vitro plasma disappearance of somatostatin-14 and somatostatin-28 in the rat (1983) Endocrinology, 112, pp. 220-225
Lamberts, S. W. J., Octreotide: The Next Decade (1999) BioScientifica, , Bristol
Veber, D. F., Freidinger, R. M., Schwenk-Perlow, D., Paleveda Jr, W. J., Holly, F. W., Strachan, R. G., Nurr, R. F., Hirschmann, R., A potent cyclic hexapeptide analogue of somatostatin (1981) Nature, 292, pp. 55-58
Patel, C. Y., Somatostatin and its receptor family (1999) Front. Neuroendocrinol. Rev, 20, pp. 157-198
Hofland, L. J., Internalization of [DOTA, 125I-Tyr3] octreotide by somatostatin receptor-positive cells in vitro and in vivo: Implications for somatostatin receptor-targeted radio-guided surgery (1999) Proc. Assoc. Am. Phys, 111, pp. 63-69
Huang, C. M., Wu, Y. T., Chen, S. T., Targeting delivery of paclitaxel into tumor cells via somatostatin receptor endocytosis (2000) Chem. Biol, 7, pp. 453-461
Krenning, E. P., Kwekkeboom, D. J., Pauwels, S., Kvols, L. K., Reubi, J. C., Somatostatin receptor scintigraphy (1995) Nucl. Med. Annu, pp. 1-50
Andre, J. P., Toth, E., Fischer, H., Seelig, A., Maecke, H. R., Merbach, A. E., High relaxivity for monomeric Gd (DOTA) -Based MRI contrast agents, thanks to micellar self-organization (1999) Chem. - Eur. J, 5, pp. 2977-2983
Gl g rd, C., Stensrud, G., Hovland, R., Fossheim, S. L., Klaveness, J., Liposomes as carriers of amphiphilic gadolinium chelates: The affect of membrane composition on incorporation efficacy and in vitro relaxivity (2002) Int. J. Pharm, 233, pp. 131-140
Mulder, W. J. M., Strijkers, G. J., Griffioen, A. W., Van Bloois, L., Molema, G., Storm, G., Koning, A., Nicolay, K., A liposomal system for contrast-enhanced magnetic resonance imaging of molecular targets (2004) Bioconjugate Chem, 15, pp. 799-806
Torchilin, V. P., Omelyanenko, V. G., Papisov, M. I., Bogdanov, A. J., Trubetskoy, V. S., Herron, J. N., Gentry, C. A., Poly (ethylene glycol) on the liposome surface: On the mechanism of polymer-coated liposome longevity (1994) Biochim. Biophys. Acta, 119, pp. 11-20
Chang, W. C., White, P. D., (2000) Fmoc Solid Phase Peptide Synthesis, , Oxford University Press: New York, USA
Birdi, K. S., Singh, H. N., Dalsager, S. U., Interaction of ionic micelles with the hydrophobic fluorescent probe 1-anilino-8-naphthalenesulfonate (1979) J. Phys. Chem, 83, pp. 2733-2737
Lackowicz, J. R., (1983) Principles of Fluorescence Spectroscopy, , Plenum Press: New York
Anelli, P. L., Fedeli, F., Gazzotti, O., Lattuada, L., Lux, G., Rebasti, F., L-glutamic acid and L-Lysine as Useful Building Blocks for the Preparation of Bifunctional DTPA-like Ligands (1999) Bioconjugate Chem, 10, pp. 137-140
Ellmann, G. L., Tissue sulfhydryl groups (1959) Arch. Biochem. Biophys, 82, pp. 70-77
Pace, C. N., Vajdos, F., Fee, L., Grimsley, G., Gray, T., How to measure and predict the molar absorption coefficient of a protein (1995) Protein Sci, 4, pp. 2411-2423
Micelles derivatized with octreotide as potential target-selective contrast agents in MRI
New amphiphilic monomers (OCA-DTPAGlu and OCA-DOTA) containing, in the same molecule, three different functions: (i) the chelating agent (DTPAGlu or DOTA) able to coordinate gadolinium ion, (ii) the octreotide bioactive peptide able to target somatostatin receptors, and (iii) a hydrophobic moiety with two 18-carbon atoms alkyl chains have been designed and synthesized by solid-phase methods. The novel amphiphilic monomers aggregate, in water solution, giving stable micelles at very low concentration (cmc values of 2.3 × 10-6 mol kg-1 and 2.5 × 10-6 mol kg-1 for OCA-DTPAGlu and OCA-DOTA, respectively) as confirmed by fluorescence spectroscopy. Fluorescence studies and circular dichroism experiments indicate, for the two compounds as well as for their gadolinium complexes (OCA-DOTA(Gd) and OCA-DTPAGlu(Gd)), the complete exposure of octreotide on the micelle surface, and the predominant presence of an antiparallel β-sheet peptide conformation characterized by a β-like turn. The high relaxivity value (r1p = 13.9mM-1 s-1 at 20 MHz and 25 °C), measured for micelles obtained by the gadolinium complex OCA-DTPAGlu(Gd), indicates these aggregates as promising target-selective magnetic resonance imaging (MRI) contrast agents. Copyright © 2008 European Peptide Society and John Wiley & Sons, Ltd.
New amphiphilic monomers (OCA-DTPAGlu and OCA-DOTA) containing, in the same molecule, three different functions: (i) the chelating agent (DTPAGlu or DOTA) able to coordinate gadolinium ion, (ii) the octreotide bioactive peptide able to target somatostatin receptors, and (iii) a hydrophobic moiety with two 18-carbon atoms alkyl chains have been designed and synthesized by solid-phase methods. The novel amphiphilic monomers aggregate, in water solution, giving stable micelles at very low concentration (cmc values of 2.3 × 10-6 mol kg-1 and 2.5 × 10-6 mol kg-1 for OCA-DTPAGlu and OCA-DOTA, respectively) as confirmed by fluorescence spectroscopy. Fluorescence studies and circular dichroism experiments indicate, for the two compounds as well as for their gadolinium complexes (OCA-DOTA(Gd) and OCA-DTPAGlu(Gd)), the complete exposure of octreotide on the micelle surface, and the predominant presence of an antiparallel β-sheet peptide conformation characterized by a β-like turn. The high relaxivity value (r1p = 13.9mM-1 s-1 at 20 MHz and 25 °C), measured for micelles obtained by the gadolinium complex OCA-DTPAGlu(Gd), indicates these aggregates as promising target-selective magnetic resonance imaging (MRI) contrast agents. Copyright © 2008 European Peptide Society and John Wiley & Sons, Ltd.
Micelles derivatized with octreotide as potential target-selective contrast agents in MRI
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Micelles derivatized with octreotide as potential target-selective contrast agents in MRI
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Longo DL, Arena F, Consolino L, Minazzi P, Geninatti-crich S, Giovenzana GB, Aime S
* Gd-AAZTA-MADEC, an improved blood pool agent for DCE-MRI studies on mice on 1 T scanners (418 views)
Biomaterials (ISSN: 0142-9612, 1878-5905electronic, 0142-9612linking), 2015 Oct 16; 75: 47-57.
Impact Factor: 8.387
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Ramundo V, Del Prete M, Marotta V, Marciello F, Camera L, Napolitano V, de LucaL, Circelli L, Colantuoni V, Di Sarno A, Carratu AC, Di Roseto CDL, Colao A, Faggiano A
* Impact of long-acting octreotide in patients with early-stage MEN1-related duodeno-pancreatic neuroendocrine tumours (495 views)
Clin Endocrinol (ISSN: 0300-0664, 1365-2265), 2014 Jun; 80(6): 850-855.
Impact Factor: 3.457
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Dynkevich Y, Rother KI, Whitford I, Qureshi S, Galiveeti S, Szulc AL, Danoff A, Breen TL, Kaviani N, Shanik MH, LeRoith D, Vigneri R, Koch CA, Roth J
* Tumors, IGF-2, and Hypoglycemia: Insights From the Clinic, the Laboratory, and the Historical Archive (1669 views)
Endocrine Reviews (ISSN: 0163-769x), 2013 Dec; 34(6): 798-826.
Impact Factor: 19.358
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Fonti R, Mainolfi C, Anzivino A, Camera L, Faggiano A, Colao A, Salvatore M, Del Vecchio S
* 18F-FDG-PET/CT and 111In-Octreotide SPECT in Patients with Metastatic Medullary Thyroid Carcinoma (270 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2013 Oct; 40: N/D-N/D.
Impact Factor: 5.217
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Calce E, Monfregola L, De Luca S
* Synthetic Strategy to Prepare DOTA-Based Bifunctional Chelating Agent Ready to Bind Biomolecular Probes (460 views)
Int J Pept Res Ther (ISSN: 1573-3149, 0929-5666), 2013 Sep; 19(3): 199-202.
Impact Factor: 0.825
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Accardo A, Mangiapia G, Paduano L, Morelli G, Tesauro D
* Octreotide labeled aggregates containing platinum complexes as nanovectors for drug delivery (408 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2013 Apr; 19(4): 190-197.
Impact Factor: 1.862
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De Luca S, Fonti R, Palmieri G, Federico P, Del Prete G, Pacelli R, Pace L, De Placido S, Salvatore M, Del Vecchio S
* Combined Imaging With 18f-Fdg-Pet/Ct And 111in-Labeled Octreotide Spect For Evaluation Of Thymic Epithelial Tumors (350 views)
Clin Nucl Med (ISSN: 1536-0229, 0363-3976, 0363-9762), 2013; 38(5): 354-358.
Impact Factor: 2.857
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Accardo A, Gianolio E, Arena F, Barnert S, Schubert R, Tesauro D, Morelli G
* Nanostructures based on monoolein or diolein and amphiphilic gadolinium complexes as MRI contrast agents (412 views)
J Mater Chem B (ISSN: 2050-7518, 2050-750x), 2013; 1(5): 617-628.
Impact Factor: 8.535
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Lanzillo R, Quarantelli M, Bonavita S, Ventrella G, Lus G, Vacca G, Prinster A, Orefice G, Tedeschi G, Brescia Morra V
* Natalizumab vs interferon beta 1a in relapsing-remitting multiple sclerosis: A head-to-head retrospective study (400 views)
Acta Neurol Scand (ISSN: 0001-6314, 1600-0404), 2012 Nov; 126(5): 306-314.
Impact Factor: 2.474
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Palmieri G, Fonti R, Federico P, Del Prete G, Pacelli R, Pace L, Salvatore M, Del Vecchio S
* Combined 18F-FDG-PET/CT and 111In-Octreotide SPECT for Evaluation of Thymic Epithelial Tumors (271 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2012 Oct; 39: N/D-N/D.
Impact Factor: 5.114
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Ocak M, Helbok A, Rangger C, Peitl PK, Nock BA, Morelli G, Eek A, Sosabowskijk, Breeman WA, Reubi JC, Decristoforo C
* Comparison of biological stability and metabolism of CCK2 receptor targeting peptides, a collaborative project under COST BM0607 (708 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2011 Sep; 38(8): 1426-1435.
Impact Factor: 4.991
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Accardo A, Morisco A, Gianolio E, Tesauro D, Mangiapia G, Radulescu A, Brandt A, Morelli G
* Nanoparticles containing octreotide peptides and gadolinium complexes for MRI applications (504 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2011 Feb; 17(2): 154-162.
Impact Factor: 1.799
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Accardo A, Morisco A, Tesauro D, Pedone C, Morelli G
* Naposomes: A new class of peptide-derivatized, target-selective multimodal nanoparticles for imaging and therapeutic applications (408 views)
Ther Deliv (ISSN: 2041-5990), 2011 Feb; 2(2): 235-257.
Impact Factor: 0
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Nardelli A, Castaldi E, Ortosecco G, Speranza A, Storto G, Pace L, Salvatore M
* Enhancement of reaction conditions for the radiolabelling of DOTA-peptides with high activities of yttrium-90 (468 views)
Applied Radiation And Isotopes (ISSN: 1872-9800, 0969-8043, 0969-8043linking), 2011 Jan; 69(1): 52-55.
Impact Factor: 1.172
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Menchise V, Digilio G, Gianolio E, Cittadino E, Catanzaro V, Carrera C, Aime S
* In vivo labeling of B16 melanoma tumor xenograft with a thiol-reactive gadolinium based MRI contrast agent (538 views)
Mol Pharm (ISSN: 1543-8384), 2011; 8(5): 1750-1756.
Impact Factor: 4.782
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Morisco A, Accardo A, Tesauro D, Palumbo R, Benedetti E, Morelli G
* Peptide-labeled supramolecular aggregates as selective doxorubicin carriers for delivery to tumor cells (360 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2011; 96(1): 88-96.
Impact Factor: 2.87
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Del Vecchio S, Zannetti A, Iommelli F, Lettieri A, Brunetti A, Salvatore M
* Molecular imaging of tumor microenvironment (504 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2010 Jun; 54(3): 243-258.
Impact Factor: 1.724
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Del Vecchio S, Zannetti A, Iommelli F, Lettieri A, Brunetti A, Salvatore M
* Molecular imaging of tumor microenvironment: Challenges and perspectives (596 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2010 Jun; 54(3): 249-258.
Impact Factor: 1.724
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Accardo A, Mansi R, Morisco A, Mangiapia G, Paduano L, Tesauro D, Radulescu A, Aurilio M, Aloj L, Arra C, Morelli G
* Peptide modified nanocarriers for selective targeting of bombesin receptors (429 views)
Mol Biosyst (ISSN: 1742-206x), 2010 May; 6(5): 878-887.
Impact Factor: 3.825
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Accardo A, Tesauro D, Aloj L, Pedone C, Morelli G
* Supramolecular aggregates containing lipophilic Gd(III) complexes as contrast agents in MRI (591 views)
Coord Chem Rev (ISSN: 0010-8545), 2009 Sep; 253(17-18): 2193-2213.
Impact Factor: 11.225
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Zaccaro L, Del Gatto A, Pedone C, Saviano M
* Peptides for tumour therapy and diagnosis: current status and future directions (1011 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2009 Mar; 16(7): 780-795.
Impact Factor: 4.708
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Supuran CT, Di Fiore A, De Simone G
* Carbonic anhydrase inhibitors as emerging drugs for the treatment of obesity (562 views)
Expert Opin Emerg Drugsexpert Opinion On Emerging Drugs (ISSN: 1472-8214), 2008 Jun; 13(2): 383-392.
Impact Factor: 3.08
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Pulcrano M, Camera L, Pagano L, Del Vecchio S, Ferone D, Bodei L, Murgia A, Pace L, Storto G, Paganelli G, Colao A, Salvatore M, Lombardi G, Biondi B
* Usefulness of [(111)In-DTPA(0)] octreotide scintigraphy in a family with von Hippel-Lindau disease (359 views)
J Endocrinol Invest (ISSN: 0391-4097, 1720-8386electronic), 2008 Apr; 31(4): 352-359.
Impact Factor: 1.888
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De Simone G, Di Fiore A, Supuran CT
* Are carbonic anhydrase inhibitors suitable for obtaining antiobesity drugs? (472 views)
Curr Pharm Des Current Pharmaceutical Design (ISSN: 1381-6128, 1873-4286), 2008 Mar; 14(7): 655-660.
Impact Factor: 4.399
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Tesauro D, Accardo A, Gianolio E, Paduano L, Teixeira J, Schillén K, Aime S, Morelli G
* Peptide derivatized lamellar aggregates as target-specific MRI contrast agents (580 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2007 May 25; 8(8): 950-955.
Impact Factor: 3.446
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Aloj L, Aurilio M, Rinaldi V, D'Ambrosio L, Tesauro D, Peitl PK, Maina T, Mansi R, Von Guggenberg E, Joosten L, Sosabowski JK, Breeman WA, De Blois E, Koelewijn S, Melis M, Waser B, Beetschen K, Reubi JC, De Jong M
* The EEE project (449 views)
Proc Int Cosm Ray Conf Icrc Universidad Nacional Autonoma De Mexico, 2007; 5(HEPART2): 977-980.
Impact Factor: 0
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Cuocolo A, Acampa W, Varrone A, Salvatore M
* Highlights of the Annual Congress of the European Association of Nuclear Medicine, Istanbul, 2005: The incremental value of nuclear medicine for patient management and care (584 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2006 Mar; 33(3): 360-381.
Impact Factor: 4.041
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Tauchmanovà L, Pensabene M, Capuano I, Spagnoletti I, Zeppa P, Del Vecchio S, Mainenti PP, De Rosa G, Colao A, Contegiacomo A
* Poorly differentiated small cell neuroendocrine carcinoma localized in three different endocrine glands: Response to chemotherapy and octreotide LAR (329 views)
J Endocrinol Invest (ISSN: 0391-4097, 1720-8386electronic), 2005 Apr; 28(4): 371-378.
Impact Factor: 1.496
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Savastano S, Pivonello R, Acampa W, Salvatore M, Lombardi G, Colao A, Fenzi G
* Recombinant thyrotropin-induced orbital uptake of [In-111-diethylenetriamine-pentacetic acid-D-phe(1)]octreotide in a patient with inactive Graves' ophthalmopathy (308 views)
Journal Of Clinical Endocrinology & Metabolism (ISSN: 0021-972x), 2005 Apr; 90(4): 2440-2444.
Impact Factor: 6.02
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Morelli G, Accardo A, Tesauro D, Pedone C, Mangiapia G, Paduano L, Gianolio E
* Multicomponent aggregates containing the CCK8 bioactive peptide and Gd complexes as target-specific MRI contrast agents (279 views)
Peptides 2004 Proceedings, 2005; N/D: N/D-N/D.
Impact Factor: 0
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Colao A, Marzullo P, Cuocolo A, Spinelli L, Pivonello R, Bonaduce D, Salvatore M, Lombardi G
* Reversal of acromegalic cardiomyopathy in young but not in middle-aged patients after 12 months of treatment with the depot long-acting somatostatin analogue octreotide (429 views)
Clin Endocrinol (ISSN: 0300-0664, 1365-2265, 1365-2265electronic), 2003 Feb; 58(2): 169-176.
Impact Factor: 2.767
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Camera L, Del Vecchio S, Quarantelli M, Ibello F, Pellegrino T, Salvatore M
* Radiolabeled somatostatin analogs in the diagnosis and staging of neuroendocrine tumors (329 views)
J Endocrinol Invest (ISSN: 0391-4097, 1720-8386electronic), 2003; 26(8Suppl): 60-62.
Impact Factor: 1.621
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Colao A, Spinelli L, Cuocolo A, Spiezia S, Pivonello R, Di Somma C, Bonaduce D, Salvatore M, Lombardi G
* Cardiovascular consequences of early-onset growth hormone excess (420 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2002 Jul; 87(7): 3097-3104.
Impact Factor: 5.199
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Colao A, Cuocolo A, Marzullo P, Nicolai E, Ferone D, Morte A, Pivonello R, Salvatore M, Lombardi G
* Is the acromegalic cardiomyopathy reversible? Effect of 5-year normalization of growth hormone and insulin-like growth factor I levels on cardiac performance (329 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2001 Apr; 86(4): 1551-1557.
Impact Factor: 5.16
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Colao A, Marzullo P, Ferone D, Spinelli L, Cuocolo A, Bonaduce D, Salvatore M, Boerlin V, Lancranjan I, Lombardi G
Cardiovascular effects of depot long-acting somatostatin analog sandostatin LAR in acromegaly (428 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2000 Sep; 85(9): 3132-3140.
Impact Factor: 5.447
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Colao A, Lastoria S, Ferone D, Varrella P, Marzullo P, Pivonello R, Cerbone G, Acampa W, Salvatore M, Lombardi G
The pituitary uptake of In-111-DTPA-D-Phe(1)-octreotide in the normal pituitary and in pituitary adenomas (387 views)
J Endocrinol Invest (ISSN: 0391-4097, 1720-8386electronic), 1999 Mar; 22(3): 176-183.
Impact Factor: 0.957
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Colao A, Cuocolo A, Marzullo P, Nicolai E, Ferone D, Florimonte L, Salvatore M, Lombardi G
Effects of 1-year treatment with octreotide on cardiac performance in patients with acromegaly (365 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 1999 Jan; 84(1): 17-23.
Impact Factor: 5.805
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Lastoria S, Vergara E, Palmieri G, Acampa W, Varrella P, Caracò C, Bianco RA, Muto P, Salvatore M
In vivo detection of malignant thymic masses by indium-111-DTPA-D- Phe1-octreotide scintigraphy (428 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1998 Apr; 39(4): 634-639.
Impact Factor: 3.064
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Ferone D, Lastoria S, Colao A, Varrella P, Cerbone G, Acampa W, Merola B, Salvatore M, Lombardi G
Correlation of scintigraphic results using 123I-methoxybenzamide with hormone levels and tumor size response to quinagolide in patients with pituitary adenomas (317 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 1998 Jan; 83(1): 248-252.
Impact Factor: 5.641
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Maurea S, Lastoria S, Caracò C, Klain M, Varrella P, Acampa W, Muto P, Salvatore M
The role of radiolabeled somatostatin analogs in adrenal imaging (358 views)
Nucl Med Biol (ISSN: 0969-8051, 0883-2897), 1996 Sep; 23(6): 677-680.
Impact Factor: 1.042
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Lastoria S, Maurea S, Vergara E, Acampa W, Varrella P, Klain M, Muto P, Bernardy JD, Salvatore M
Comparison of labeled MIBG and somatostatin analogs in imaging neuroendocrine tumors (336 views)
Q J Nucl Med (ISSN: 1125-0135, 1124-3937), 1995 Dec; 39(4Suppl1): 145-149.
Impact Factor: 2.125
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Palmeieri G, Lastoria S, Vergara E, Varrella P, Acampa W, Salvatore M, Bianco AR
Diagnosis and treatment of thymoma by octreotide (234 views)
Meetingproceedings Of The American Association For Cancer Research Annual (ISSN: 0197-016x), 1995; 36(0): N/D-N/D.
Impact Factor: 0
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LASTORIA S, COLAO A, VERGARA E, FERONE D, VARRELLA P, MEROLA B, ACAMPA W, LOMBARDI G, SALVATORE M
IN-111 OCTREOTIDE UPTAKE LEVELS IN PITUITARY-ADENOMAS TO PREDICT THE RESPONSIVENESS TO CHRONIC OCTREOTIDE TREATMENT (240 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1994 May; 35(5): N/D-N/D.
Impact Factor: 3.491
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LASTORIA S, VERGARA E, VARRELLA P, ACAMPA W, PALMIERI G, SALVATORE M
IN-VIVO DETECTION OF NEW DISEASES EXPRESSING SOMATOSTATIN RECEPTORS BY IN-111 OCTREOTIDE (267 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1994 May; 35(5): N/D-N/D.
Impact Factor: 3.491
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LASTORIA S, VERGARA E, VARRELLA P, ACAMPA W, PALMIERI G, SALVATORE M
IN-VIVO DETECTION OF NEW NEOPLASTIC LESIONS EXPRESSING SOMATOSTATIN RECEPTORS USING IN-111 OCTREOTIDE (293 views)
Posters Tomes 1 4proceedings Of The Xvi International Cancer Congress Free Papers And, 1994; N/D: N/D-N/D.
Impact Factor: 0
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52 Records (45 excluding Abstracts).
Total impact factor: 202.009 (184.696 excluding Abstracts).
Total 5 year impact factor: 198.379 (178.168 excluding Abstracts).
Total impact factor: 202.009 (184.696 excluding Abstracts).
Total 5 year impact factor: 198.379 (178.168 excluding Abstracts).
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