A vascular endothelial growth factor mimetic accelerates gastric ulcer healing in an iNOS-dependent manner(801 views) Dudar GK, D'Andrea LD, Di Stasi R, Pedone C, Wallace JL
Am J Physiol Gastrointest Liver Physiol American Journal Of Physiology Gastrointestinal And Liver Physiology (ISSN: 0193-1857), 2008 Sep; 295(2): G374-G381.
Inflammation Research Network, University of Calgary, Calgary, AB, Canada
Istituto di Biostrutture e Bioimmagini, Consiglio Nazionale Delle Ricerche, Napoli, Italy
Dept. of Pharmacology and Therapeutics, Univ. of Calgary, 3330 Hospital Dr. NW, Calgary, AB T2N 4N1, Canada
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Wallace, J.L., Dicay, M., McKnight, W., Dudar, G.K., Platelets accelerate gastric ulcer healing through presentation of vascular endothelial growth factor (2006) Br J Pharmacol, 148, pp. 274-278
Wallace, J.L., Miller, M.J., Nitric oxide in mucosal defense: A little goes a long way (2000) Gastroenterology, 119, pp. 512-520
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D'Andrea, L. D., Iaccarino, G., Fattorusso, R., Sorriento, D., Carannante, C., Capasso, D., Trimarco, B., Pedone, C., Targeting angiogenesis: Structural characterization and biological properties of a de novo engineered VEGF mimicking peptide (2005) Proc Natl Acad Sci USA, 102, pp. 14215-14220
Davies, N. M., R seth, A. G., Appleyard, C. B., McKnight, W., Del Soldato, P., Calignano, A., Cirino, G., Wallace, J. L., NO-naproxen vs. naproxen: Ulcerogenic, analgesic and anti-inflammatory effects (1997) Aliment Pharmacol Ther, 11, pp. 69-79
Davies, N. M., Sharkey, K. A., Asfaha, S., MacNaughton, W. K., Wallace, J. L., Aspirin causes rapid up-regulation of cyclo-oxygenase-2 expression in the stomach of rats (1997) Aliment Pharmacol Ther, 11, pp. 1101-1108
Elliott, S. N., McKnight, W., Cirino, G., Wallace, J. L., A nitric oxide releasing nonsteroidal anti-inflammatory drug accelerates gastric ulcer healing in rats (1995) Gastroenterology, 109, pp. 524-530
Jones, M. K., Kawanaka, H., Baatar, D., Szabo, I. L., Tsugawa Pai, R., Koh, G. Y., Kim, I., Tarnawski, A. S., Gene therapy for gastric ulcers with single local injection of naked DNA encoding VEGF and angiopoietin-1 (2001) Gastroenterology, 121, pp. 1040-1047
Konturek, S. J., Brzozowski, T., Majka, J., Pytko-Polonczyk, J., Stachura, J., Inhibition of nitric oxide synthase delays healing of chronic gastric ulcers (1993) Eur J Pharmacol, 239, pp. 215-217
Konturek, S. J., Role of growth factors in gastroduodenal protection and healing of peptic ulcers (1990) Gastroenterol Clin North Am, 19, pp. 41-65
Maloney, J. P., Silliman, C. C., Ambruso, D. R., Wan, J., Tuder, R. M., Voelkel, N. F., In vitro release of vascular endothelial growth factor during platelet aggregation (1998) Am J Physiol Heart Circ Physiol, 275, pp. H1054-H1061
Moore, W. M., Webber, R. K., Jerome, G. M., Tjoeng, F. S., Misko, T. P., Currie, M. G., L-N6- (1-iminoethyl) lysine: A selective inhibitor of inducible nitric oxide synthase (1994) J Med Chem, 37, pp. 3886-3888
Podolsky, D. K., Review article: Healing after inflammatory injury - coordination of a regulatory peptide network (2000) Aliment Pharmacol Ther, 14 (SUPPL. 1), pp. 87-93
Rees, D. D., Palmer, R. M., Schulz, R., Hodson, H. F., Moncada, S., Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo (1990) Br J Pharmacol, 101, pp. 746-752
Reuter, B. K., Asfaha, S., Buret, A., Sharkey, K. A., Wallace, J. L., Exacerbation of inflammation-associated colonic injury in rat through inhibition of cyclooxygenase-2 (1996) J Clin Invest, 98, pp. 2076-2085
Reuter, B. K., Davies, N. M., Wallace, J. L., Nonsteroidal anti-inflammatory drug enteropathy in rats: Role of permeability, bacteria, and enterohepatic circulation (1997) Gastroenterology, 112, pp. 109-117
Saif, M. W., Elfiky, A., Salem, R. R., Gastrointestinal perforation due to bevacizumab in colorectal cancer (2007) Ann Surg Oncol, 14, pp. 1860-1869
Szabo, I. L., Pai, R., Soreghan, B., Jones, M. K., Baatar, D., Kawanaka, H., Tarnawski, A., NSAIDs inhibit the activation of egr-1 gene in microvascular endothelial cells. A key to inhibition of angiogenesis? (2001) J Physiol Paris, 95, pp. 379-383
Tarnawski, A. S., Cellular and molecular mechanisms of gastrointestinal ulcer healing (2005) Dig Dis Sci, 50, pp. S24-S33
Wallace, J. L., Bak, A., McKnight, W., Asfaha, S., Sharkey, K. A., MacNaughton, W. K., Cyclooxygenase 1 contributes to inflammatory responses in rats and mice: Implications for gastrointestinal toxicity (1998) Gastroenterology, 115, pp. 101-109
Wallace, J. L., Chapman, K., McKnight, W., Limited anti-inflammatory efficacy of cyclo-oxygenase-2 inhibition in carrageenan-airpouch inflammation (1999) Br J Pharmacol, 126, pp. 1200-1204
Wallace, J. L., del Soldato, P., The therapeutic potential of NO-NSAIDs (2003) Fundam Clin Pharmacol, 17, pp. 11-20
Wallace, J. L., Dicay, M., McKnight, W., Dudar, G. K., Platelets accelerate gastric ulcer healing through presentation of vascular endothelial growth factor (2006) Br J Pharmacol, 148, pp. 274-278
Wallace, J. L., Miller, M. J., Nitric oxide in mucosal defense: A little goes a long way (2000) Gastroenterology, 119, pp. 512-520
Wallace, J. L., McKnight, W., Reuter, B. K., Vergnolle, N., NSAID-induced gastric damage in rats: Requirement for inhibition of both cyclooxygenase 1 and 2 (2000) Gastroenterology, 119, pp. 706-714
Wallace, J. L., Tigley, A. W., Review article: New insights into prostaglandins and mucosal defence (1995) Aliment Pharmacol Ther, 9, pp. 227-235
Wang, J. Y., Yamasaki, S., Takeuchi, K., Okabe, S., Delayed healing of acetic acid-induced gastric ulcers in rats by indomethacin (1989) Gastroenterology, 96, pp. 393-402
Zanardo, R. C., Brancaleone, V., Distrutti, E., Fiorucci, S., Cirino, G., Wallace, J. L., Hydrogen sulfide is an endogenous modulator of leukocyte-mediated inflammation (2006) FASEB J, 20, pp. 2118-2120
A vascular endothelial growth factor mimetic accelerates gastric ulcer healing in an iNOS-dependent manner
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