BRAF(V600E) mutation and the biology of papillary thyroid cancer (545 views)
Endocr Relat Cancerendocrine Related Cancer (ISSN: 1351-0088), 2008; 15(1): 191-205.
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Paper type: Journal Article,
Impact factor: 5.236, 5-year impact factor: 5.827
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-41349122686&partnerID=40&md5=2976707d7651f4c931f181d71866efc6
Keywords: B Raf Kinase, Carcinogen, Gelatinase B, Iodine, Adult, Age Distribution, Article, Cancer Invasion, Cervical Lymph Node, Environmental Factor, Female, Gender, Gene Mutation, Genetic Association, Geography, Human, Human Tissue, Italy, Lymph Node Metastasis, Major Clinical Study, Molecular Biology, Multivariate Analysis, Multivariate Logistic Regression Analysis, Papillary Thyroid Cancer, Polymerase Chain Reaction, Protein Expression, Statistical Significance, Tumor Volume, Univariate Analysis, Disease Progression, Dna Primers, Follow-Up Studies, Immunoenzyme Techniques, Lasers, Lymphatic Metastasis, Matrix Metalloproteinase 9, Microdissection, Middle Aged, Neoplasm Invasiveness, Proto-Oncogene Proteins B-Raf, Reverse Transcriptase Polymerase Chain Reaction, Messenger, Sicily, Thyroid Neoplasms,
Affiliations:
*** IBB - CNR ***
Endocrinologia, Dipartimento di Medicina Interna e Medicina Specialistica, University of Catania, PO Garibaldi Nesima, Via Palermo 636, 95122 Catania, Italy
Dipartimento Clinico-Sperimentale di Medicina e Farmacologia, Azienda Ospedaliera Universitaria Policlinico, University of Messina, Via Consolare Valeria, 98122 Messina, Italy
Unità Operativa di Anatomia Patologica, Ospedale Vittorio Emanuele, Via Plebiscito 628, 95124 Catania, Italy
Divisione di Endocrinologia, Ospedale Cervello, 90146 Palermo, Italy
Servizio di Anatomia Patologica, Ospedale Cervello, Via Trabucco 180, 90146 Palermo, Italy
Pathology Department, Harvard Medical School, Brigham and Women's Hospital, 44 Binney Street, Boston, MA, United States
Sezione di Endocrinologia, Dipartimento di Oncologia Sperimentale Clinica, Policlinico, Via del Vespro 129, 90127 Palermo, Italy
Unit Operativa di Anatomia Patologica, Ospedale Vittorio Emanuele, Via Plebiscito 628, 95124 Catania, Italy
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Baloch, Z. W., Mandel, S., LiVolsi, V. A., Combined tall cell carcinoma and Hurthle cell carcinoma (collision tumor) of the thyroid (2001) Archives of Pathology & Laboratory Medicine, 125, pp. 541-543
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Garnett, M. J., Marais, R., Guilty as charged: BRAF is a human oncogene (2004) Cancer Cell, 6, pp. 313-319
Giordano, T. J., Kuick, R., Thomas, D. G., Misek, D. E., Vinco, M., Sanders, D., Zhu, Z., Shedden, K., Molecular classification of papillary thyroid carcinoma: Distinct BRAF, RAS, and RET/PTC mutation-specific gene expression profiles discovered by DNA microarray analysis (2005) Oncogene, 24, pp. 6646-6656
Hernandez, B. Y., Highlights of recent cancer incidence data in Hawaii (2003) Hawaii Medical Journal, 62, pp. 17-18
Howe, H. L., Wingo, P. A., Thun, M. J., Ries, L. A., Rosenberg, H. M., Feigal, E. G., Edwards, B. K., Annual report to the nation on the status of cancer (1973 through 1998), featuring cancers with recent increasing trends (2001) Journal of the National Cancer Institute, 93, pp. 824-842
Jin, L., Sebo, T. J., Nakamura, N., Qian, X., Oliveira, A., Majerus, J. A., Johnson, M. R., Lloyd, R. V., BRAF mutation analysis in fine needle aspiration (FNA) cytology of the thyroid (2006) Diagnostic Molecular Pathology, 15, pp. 136-143
Jo, Y. S., Li, S., Song, J. H., Kwon, K. H., Lee, J. C., Rha, S. Y., Lee, H. J., Ro, H. K., Influence of the BRAF V600E mutation on expression of vascular endothelial growth factor in papillary thyroid cancer (2006) Journal of Clinical Endocrinology and Metabolism, 91, pp. 3667-3670
Kim, K. H., Kang, D. W., Kim, S. H., Seong, I. O., Kang, D. Y., Mutations of the BRAF gene in papillary thyroid carcinoma in a Korean population (2004) Yonsei Medical Journal, 45, pp. 818-821
Kim, T. Y., Kim, W. B., Song, J. Y., Rhee, Y. S., Gong, G., Cho, Y. M., Kim, S. Y., Shong, Y. K., The BRAF mutation is not associated with poor prognostic factors in Korean patients with conventional papillary thyroid microcarcinoma (2005) Clinical Endocrinology, 63, pp. 588-593
Kolonel, L. N., Cancer incidence among Filipinos in Hawaii and the Philippines (1985) National Cancer Institute Monographs, 69, pp. 93-98
Lee, J. H., Lee, E. S., Kim, Y. S., Won, N. H., Chae, Y. S., BRAF mutation and AKAP9 expression in sporadic papillary thyroid carcinomas (2006) Pathology, 38, pp. 201-204
Lin, J. D., Chen, S. T., Chao, T. C., Hsueh, C., Weng, H. F., Diagnosis and therapeutic strategy for papillary thyroid micro carcinoma (2005) Archives of Surgery, 140, pp. 940-945
Liu, R. T., Chen, Y. J., Chou, F. F., Li, C. L., Wu, W. L., Tsai, P. C., Huang, C. C., Cheng, J. T., No correlation between BRAFV600E mutation and clinicopathological features of papillary thyroid carcinomas in Taiwan (2005) Clinical Endocrinology, 63, pp. 461-466
Lo, C. Y., Chan, W. F., Lang, B. H., Lam, K. Y., Wan, K. Y., Classical and follicular variant of papillary thyroid carcinoma: A comparative study on clinicopathologic features and long-term outcome (2006) World Journal of Surgery, 30, pp. 752-758
Melillo, R. M., Castellone, M. D., Guarino, V., De Falco, V., Cirafici, A. M., Salvatore, G., Caiazzo, F., Kruhoffer, M., The RET/PTC-RAS-BRAF linear signaling cascade mediates the motile and mitogenic phenotype of thyroid cancer cells (2005) Journal of Clinical Investigation, 115, pp. 1068-1081
Mitsiades, C. S., Negri, J., McMullan, C., McMillin, D. W., Sozopoulos, E., Fanourakis, G., Voutsinas, G., Batt, D., Targeting BRAFV600E in thyroid carcinoma: Therapeutic implications (2007) Molecular Cancer Therapeutics, 6, pp. 1070-1078
Nikiforov, Y. E., RET/PTC rearrangement in thyroid tumors (2002) Endocrine Pathology, 13, pp. 3-16
Nikiforov, Y. E., Genetic alterations involved in the transition from well-differentiated to poorly differentiated and anaplastic thyroid carcinomas (2004) Endocrine Pathology, 15, pp. 319-327
Nikiforova, M. N., Kimura, E. T., Gandhi, M., Biddinger, P. W., Knauf, J. A., Basolo, F., Zhu, Z., Fusco, A., BRAF mutations in thyroid tumors are restricted to papillary carcinomas and anaplastic or poorly differentiated carcinomas arising from papillary carcinomas (2003) Journal of Clinical Endocrinology and Metabolism, 88, pp. 5399-5404
Park, S. Y., Park, Y. J., Lee, Y. J., Lee, H. S., Choi, S. H., Choe, G., Jang, H. C., Cho, B. Y., Analysis of differential BRAF (V600E) mutational status in multifocal papillary thyroid carcinoma: Evidence of independent clonal origin in distinct tumor foci (2006) Cancer, 107, pp. 1831-1838
Pelizzo, M. R., Boschin, I. M., Toniato, A., Pagetta, C., Piotto, A., Bernante, P., Casara, D., Rubello, D., Natural history, diagnosis, treatment and outcome of papillary thyroid microcarcinoma (PTMC): A mono-institutional 12-year experience (2004) Nuclear Medicine Communications, 25, pp. 547-552
Quiros, R. M., Ding, H. G., Gattuso, P., Prinz, R. A., Xu, X., Evidence that one subset of anaplastic thyroid carcinomas are derived from papillary carcinomas due to BRAF and p53 mutations (2005) Cancer, 103, pp. 2261-2268
Sapio, M. R., Posca, D., Troncone, G., Pettinato, G., Palombini, L., Rossi, G., Fenzi, G., Vitale, M., Detection of BRAF mutation in thyroid papillary carcinomas by mutant allele-specific PCR amplification (MASA) (2006) European Journal of Endocrinology, 154, pp. 341-348
Tronko, M. D., Howe, G. R., Bogdanova, T. I., Bouville, A. C., Epstein, O. V., Brill, A. B., Likhtarev, I. A., Greenebaum, E., A cohort study of thyroid cancer and other thyroid diseases after the chornobyl accident: Thyroid cancer in Ukraine detected during first screening (2006) Journal of the National Cancer Institute, 98, pp. 897-903
Zwi, L. J., LiVolsi, V. A., Hurthle cell carcinoma arising from thyroid papillary carcinoma (2002) Endocrine Pathology, 13, pp. 213-217
Endocr Relat Cancerendocrine Related Cancer (ISSN: 1351-0088), 2008; 15(1): 191-205.
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Paper type: Journal Article,
Impact factor: 5.236, 5-year impact factor: 5.827
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-41349122686&partnerID=40&md5=2976707d7651f4c931f181d71866efc6
Keywords: B Raf Kinase, Carcinogen, Gelatinase B, Iodine, Adult, Age Distribution, Article, Cancer Invasion, Cervical Lymph Node, Environmental Factor, Female, Gender, Gene Mutation, Genetic Association, Geography, Human, Human Tissue, Italy, Lymph Node Metastasis, Major Clinical Study, Molecular Biology, Multivariate Analysis, Multivariate Logistic Regression Analysis, Papillary Thyroid Cancer, Polymerase Chain Reaction, Protein Expression, Statistical Significance, Tumor Volume, Univariate Analysis, Disease Progression, Dna Primers, Follow-Up Studies, Immunoenzyme Techniques, Lasers, Lymphatic Metastasis, Matrix Metalloproteinase 9, Microdissection, Middle Aged, Neoplasm Invasiveness, Proto-Oncogene Proteins B-Raf, Reverse Transcriptase Polymerase Chain Reaction, Messenger, Sicily, Thyroid Neoplasms,
Affiliations:
*** IBB - CNR ***
Endocrinologia, Dipartimento di Medicina Interna e Medicina Specialistica, University of Catania, PO Garibaldi Nesima, Via Palermo 636, 95122 Catania, Italy
Dipartimento Clinico-Sperimentale di Medicina e Farmacologia, Azienda Ospedaliera Universitaria Policlinico, University of Messina, Via Consolare Valeria, 98122 Messina, Italy
Unità Operativa di Anatomia Patologica, Ospedale Vittorio Emanuele, Via Plebiscito 628, 95124 Catania, Italy
Divisione di Endocrinologia, Ospedale Cervello, 90146 Palermo, Italy
Servizio di Anatomia Patologica, Ospedale Cervello, Via Trabucco 180, 90146 Palermo, Italy
Pathology Department, Harvard Medical School, Brigham and Women's Hospital, 44 Binney Street, Boston, MA, United States
Sezione di Endocrinologia, Dipartimento di Oncologia Sperimentale Clinica, Policlinico, Via del Vespro 129, 90127 Palermo, Italy
Unit Operativa di Anatomia Patologica, Ospedale Vittorio Emanuele, Via Plebiscito 628, 95124 Catania, Italy
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BRAF(V600E) mutation and the biology of papillary thyroid cancer
BRAF(V600E) mutation is the most frequent genetic alteration in papillary thyroid carcinomas (PTCs) that are 80-90% of all thyroid cancers. We evaluated the relationship between BRAF(V600E) and tumor, host, and environmental factors in PTCs from all geographical areas of Sicily. By PCR, BRAF(V600E) was investigated in a series of 323 PTCs diagnosed in 2002-2005. The correlation between clinicopathological tumor, host, and environmental characteristics and the presence of BRAF(V600E) were evaluated by both univariate and multivariate analyses. BRAF(V600E) was found in 38.6% PTCs, with a 52% frequency in the classical PTCs and 26.4% in the tall cell variant. Univariate analysis indicated that BRAF (V600E) was associated with greater tumor size (P=0.0048), extra-thyroid invasion (P<0.0001), and cervical lymph nodal metastases (P=0.0001). Multivariate logistic regression analysis confirmed that BRAF (V600E) was an independent predictor of extra-thyroid invasion (P = 0.0001) and cervical lymph nodal metastasis (P=0.0005). The association between BRAF(V600E) and extra-thyroid invasion was also found in micro-PTCs (P = 0.006). In 60 classical PTCs, BRAF(V600E) was positively correlated with matrix metalloproteinase-9 expression (P = 0.0047), suggesting a possible mechanism for BRAF(V600E) effect on PTC invasiveness. No association was found between BRAF(V600E) and patient age, gender, or iodine intake. In contrast, a strong association was found with residency in Eastern Sicily (P<0.0001 compared with Western Sicily). These results indicate that BRAF(V600E) mutation is a marker of aggressive disease in both micro- and macro-PTCs. Moreover, for the first time, a possible link between BRAF(V600E) mutation and environmental carcinogens is suggested. © 2008 Society for Endocrinology.
BRAF(V600E) mutation is the most frequent genetic alteration in papillary thyroid carcinomas (PTCs) that are 80-90% of all thyroid cancers. We evaluated the relationship between BRAF(V600E) and tumor, host, and environmental factors in PTCs from all geographical areas of Sicily. By PCR, BRAF(V600E) was investigated in a series of 323 PTCs diagnosed in 2002-2005. The correlation between clinicopathological tumor, host, and environmental characteristics and the presence of BRAF(V600E) were evaluated by both univariate and multivariate analyses. BRAF(V600E) was found in 38.6% PTCs, with a 52% frequency in the classical PTCs and 26.4% in the tall cell variant. Univariate analysis indicated that BRAF (V600E) was associated with greater tumor size (P=0.0048), extra-thyroid invasion (P<0.0001), and cervical lymph nodal metastases (P=0.0001). Multivariate logistic regression analysis confirmed that BRAF (V600E) was an independent predictor of extra-thyroid invasion (P = 0.0001) and cervical lymph nodal metastasis (P=0.0005). The association between BRAF(V600E) and extra-thyroid invasion was also found in micro-PTCs (P = 0.006). In 60 classical PTCs, BRAF(V600E) was positively correlated with matrix metalloproteinase-9 expression (P = 0.0047), suggesting a possible mechanism for BRAF(V600E) effect on PTC invasiveness. No association was found between BRAF(V600E) and patient age, gender, or iodine intake. In contrast, a strong association was found with residency in Eastern Sicily (P<0.0001 compared with Western Sicily). These results indicate that BRAF(V600E) mutation is a marker of aggressive disease in both micro- and macro-PTCs. Moreover, for the first time, a possible link between BRAF(V600E) mutation and environmental carcinogens is suggested. © 2008 Society for Endocrinology.
BRAF(V600E) mutation and the biology of papillary thyroid cancer
BRAF(V600E) mutation and the biology of papillary thyroid cancer
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View Export to BibTeX Export to EndNote
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Impact Factor: 4.922
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Malgieri G, Palmieri M, Esposito S, Maione V, Russo L, Baglivo I, De Paola I, Milardi D, Diana D, Zaccaro L, Pedone PV, Fattorusso R, Isernia C
* Zinc To Cadmium Replacement In The Prokaryotic Zinc-Finger Domain (458 views)
Metallomics (ISSN: 1756-591x, 1756-5901, 1756-591xelectronic), 2013 Dec 18; 6(1): 96-104.
Impact Factor: 3.978
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Bera S, De Rosa V, Rachidi W, Diamond AM
* Does a role for selenium in DNA damage repair explain apparent controversies in its use in chemoprevention? (840 views)
Mutagenesismutagenesis (ISSN: 0267-8357, 1464-3804electronic, 0267-8357linking), 2013 Mar; 28(2): 127-134.
Impact Factor: 3.497
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Riccio A, Cubellis MV
* Gain of function in CDKN1C (512 views)
Nature Genetics (ISSN: 1061-4036), 2012 Jul; 44(7): 737-738.
Impact Factor: 35.209
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Merolla F, Luise C, Muller MT, Pacelli R, Fusco A, Celetti A
* Loss of CCDC6, the First Identified RET Partner Gene, Affects pH2AX S139 Levels and Accelerates Mitotic Entry upon DNA Damage (364 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2012 May 24; 7(5): N/D-N/D.
Impact Factor: 3.73
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De Rosa V, Erkekoǧlu P, Forestier A, Favier A, Hincal F, Diamond AM, Douki T, Rachidi W
* Low doses of selenium specifically stimulate the repair of oxidative DNA damage in LNCaP prostate cancer cells (893 views)
Free Radic Res Free Radical Research (ISSN: 1071-5762), 2012; 46(2): 105-115.
Impact Factor: 3.279
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Malgieri G, Zaccaro L, Leone M, Bucci E, Esposito S, Baglivo I, Del Gatto A, Russo L, Scandurra R, Pedone PV, Fattorusso R, Isernia C
* Zinc to Cadmium Replacement in the A. thaliana SUPERMAN Cys(2)His(2) Zinc Finger Induces Structural Rearrangements of Typical DNA Base Determinant Positions (445 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2011 Nov; 95(11): 801-810.
Impact Factor: 2.87
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Durazzo M, Campion D, Fagoonee S, Pellicano R, Sonne JU, Erckenbrecht JF, Grassi M, Petraccia L, Mennuni G, Fontana M, Scarno A, Sabetta S, Fraioli A
* Changes, functional disorders, and diseases in the gastrointestinal tract of elderly (165 views)
Hepatology (ISSN: 1827-1669electronic, 0026-4806linking, 1432-1289electronic), 2011 Jul; 2655108(6): 659-668.
Impact Factor: 0.913
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Gulyas B, Vas A, Toth M, Takano A, Varrone A, Cselenyi Z, Schain M, Mattsson P, Halldin C
* Age and disease related changes in the translocator protein (TSPO) system in the human brain: Positron emission tomography measurements with [11C]vinpocetine (596 views)
Neuroimage (ISSN: 1053-8119, 1053-8119linking), 2011 Jun 1; 56(3): 1111-1121.
Impact Factor: 5.895
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Lonardo E, Parish CL, Ponticelli S, Marasco D, Ribeiro D, Ruvo M, De Falco S, Arenas E, Minchiotti G
* A Small Synthetic Cripto Blocking Peptide Improves Neural Induction, Dopaminergic Differentiation, and Functional Integration of Mouse Embryonic Stem Cells in a Rat Model of Parkinson's Disease (775 views)
Stem Cells (ISSN: 1066-5099), 2010 Sep; 28(8): 1326-1337.
Impact Factor: 7.871
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Bombardieri E, Ambrosini V, Aktolun C, Baum RP, Bishof-delaloye A, Del Vecchio S, Maffioli L, Mortelmans L, Oyen W, Pepe G, Chiti A
* In-111-pentetreotide scintigraphy: procedure guidelines for tumour imaging (479 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2010 Jul; 37(7): 1441-1448.
Impact Factor: 5.036
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Del Vecchio S, Zannetti A, Fonti R, Iommelli F, Pizzuti LM, Lettieri A, Salvatore M
* PET/CT in cancer research: From preclinical to clinical applications (637 views)
Contrast Media Mol Imaging (ISSN: 1555-4309, 1555-4309linking), 2010 Jul; 5(4): 190-200.
Impact Factor: 4.02
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Tosco A, Monti MC, Fontanella B, Montefusco S, D'Andrea LD, Ziaco B, Baldantoni D, Rio MC, Marzullo L
* Copper binds the carboxy-terminus of trefoil protein 1 (TFF1), favoring its homodimerization and motogenic activity (1377 views)
Cell Mol Life Sci (ISSN: 1420-9071electronic, 1420-682xlinking), 2010 Jun; 67(11): 1943-1955.
Impact Factor: 7.047
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Del Vecchio S, Zannetti A, Iommelli F, Lettieri A, Brunetti A, Salvatore M
* Molecular imaging of tumor microenvironment (504 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2010 Jun; 54(3): 243-258.
Impact Factor: 1.724
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Del Vecchio S, Zannetti A, Iommelli F, Lettieri A, Brunetti A, Salvatore M
* Molecular imaging of tumor microenvironment: Challenges and perspectives (597 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2010 Jun; 54(3): 249-258.
Impact Factor: 1.724
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De Simone G, Supuran CT
* Carbonic anhydrase IX: Biochemical and crystallographic characterization of a novel antitumor target (400 views)
Bba-Gen Subjects (ISSN: 1570-9639, 0006-3002, 0925-4439), 2010 Feb; 1804(2): 404-409.
Impact Factor: 2.773
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Capaccio D, Ciccodicola A, Sabatino L, Casamassimi A, Pancione M, Fucci A, Febbraro, Merlino A, Graziano G, Colantuoni V
* A novel germline mutation in Peroxisome Proliferator-Activated Receptor γ gene associated with large intestine polyp formation and dyslipidemia (431 views)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2010; 1802(6): 572-581.
Impact Factor: 2.773
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Guler OO, De Simone G, Supuran CT
* Drug design studies of the novel antitumor targets carbonic anhydrase IX and XII (541 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2010; 17(15): 1516-1526.
Impact Factor: 4.63
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Farina AR, Tacconelli A, Cappabianca L, Cea G, Chioda A, Romanelli A, Pensato S, Pedone C, Gulino A, Mackay AR
* The neuroblastoma tumour-suppressor TrkAI and its oncogenic alternative TrkAIII splice variant exhibit geldanamycin-sensitive interactions with Hsp90 in human neuroblastoma cells (389 views)
Oncogene (ISSN: 1476-5594, 0950-9232), 2009 Nov 19; 28(46): 4075-4094.
Impact Factor: 7.135
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Carriero MV, Longanesi-cattani I, Bifulco K, Maglio O, Lista L, Barbieri A, Votta G, Masucci MT, Arra C, Franco R, De Rosa M, Stoppelli MP, Pavone V
* Structure-based design of an urokinase-type plasminogen activator receptor-derived peptide inhibiting cell migration and lung metastasis (498 views)
Mol Cancer Ther (ISSN: 1535-7163, 1538-8514electronic, 1535-7163linking), 2009 Sep; 8(9): 2708-2717.
Impact Factor: 4.953
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Calvanese L, Saporito A, Oliva R, D'Auria G, Pedone C, Paolillo L, Ruvo M, Marasco D, Falcigno L
* Structural insights into the interaction between the Cripto CFC domain and the ALK4 receptor (489 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 175-183.
Impact Factor: 1.807
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Gioia M, Monaco S, Van Den Steen PE, Sbardella D, Grasso G, Marini S, Overall CM, Opdenakker G, Coletta M
* The Collagen Binding Domain of Gelatinase A Modulates Degradation of Collagen IV by Gelatinase (460 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2009; 386(2): 419-434.
Impact Factor: 3.871
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Gallotta G, Palmieri V, Piedimonte V, Rendina D, De Bonis S, Russo V, Celentano A, Di Minno M, Postiglione A, Di Minno G
* Increased troponin I predicts in-hospital occurrence of hemodynamic instability in patients with sub-massive or non-massive pulmonary embolism independent to clinical, echocardiographic and laboratory information (332 views)
Int J Cardiol (ISSN: 0167-5273, 1874-1754electronic, 0167-5273linking), 2008 Mar 14; 124(3): 351-357.
Impact Factor: 3.121
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Migliore T, Parrella LS, Caputi A, Silvestri N, Romano R, Pace L, Imbriaco M, Losi MA, Betocchi S
* Pathogenesis of hypertrophic cardiomyopathy. Impact of growth factors on left ventricular anatomy (368 views)
Minerva Cardioangiol (ISSN: 0026-4725), 2008 Feb; 56(1): 13-20.
Impact Factor: 0.481
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Marchelli R, Saviano M, Licandro E, Spoto G, Borgatti M, Gambari R
* PNAs targeting the "RNA world": Micro RNA next? (401 views)
Minerva Biotecnol (ISSN: 1120-4826), 2008; 20(4): 183-188.
Impact Factor: 0.1
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Merolla F, Pentimalli F, Pacelli R, Vecchio G, Fusco A, Grieco M, Celetti A
* Involvement of H4(D10S170) protein in ATM-dependent response to DNA damage (622 views)
Oncogene (ISSN: 0950-9232, 1476-5594), 2007 Sep 13; 26(42): 6167-6175.
Impact Factor: 6.44
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Mainenti PP, Cirillo LC, Camera L, Persico F, Cantalupo T, Pace L, De Palma GD, Persico G, Salvatore M
* Accuracy of single phase contrast enhanced multidetector CT colonography in the preoperative staging of colo-rectal cancer (321 views)
Eur J Radiol (ISSN: 0720-048x), 2006 Dec; 60(3): 453-459.
Impact Factor: 1.332
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Magliulo M, Alfano B, Salvatore M
* PACS integration with non-standard HIS and RIS (333 views) (PDF 223 views)
Surgery International Congress Series Car 97 (ISSN: 0531-5131), 2005 May; 1281: 894-899.
Impact Factor: 1.438
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Tedesco I, Nappo A, Petitto F, Iacomino G, Nazzaro F, Palumbo R, Russo Gian L
* Antioxidant and cytotoxic properties of lyophilized beer extracts on HL-60 cell line (752 views)
Nutr Cancer (ISSN: 0163-5581), 2005; 52(1): 74-83.
Impact Factor: 2.426
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Borgatti M, Boyd DD, Lampronti I, Bianchi N, Fabbri E, Saviano M, Romanelli A, Pedone C, Gambari R
* Decoy molecules based on PNA-DNA chimeras and targeting Sp1 transcription factors inhibit the activity of urokinase-type plasminogen activator receptor (uPAR) promoter (439 views)
Oncology Research (ISSN: 0965-0407), 2005; 15(7-8): 373-383.
Impact Factor: 1.844
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Russo M, Tedesco I, Iacomino G, Palumbo R, Galano G, Russo GL
* Dietary phytochemicals in chemoprevention of cancer (351 views)
Curr Med Chem (ISSN: 1568-0134), 2005; 5(1): 61-72.
Impact Factor: 3.715
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Borgatti M, Romanelli A, Saviano M, Pedone C, Lampronti I, Breda L, Nastruzzi C, Bianchi N, Mischiati C, Gambari R
* Resistance of decoy PNA-DNA chimeras to enzymatic degradation in cellular extracts and serum (430 views)
Oncology Research (ISSN: 0965-0407), 2003; 13(5): 279-287.
Impact Factor: 1.794
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Monti SM, Ritieni A, Sacchi R, Skog K, Borgen E, Fogliano V
* Characterization of phenolic compounds in virgin olive oil and their effect on the formation of carcinogenic/mutagenic heterocyclic amines in a model system (644 views)
J Agric Food Chem (ISSN: 0021-8561), 2001 Sep; 49(8): 3969-3975.
Impact Factor: 1.576
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Cirillo LC, Mainenti PP, Imbriaco M, Franco R, Gatta G, De Rosa G, Salvatore M
* Synchronous primary adenocarcinoma and adenosquamous carcinoma of the esophagus (215 views)
Eur Radiol (ISSN: 0938-7994, 1432-1084electronic, 0938-7994linking), 2001; 11(10): 1964-1967.
Impact Factor: 1.321
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Monti SM, Fogliano V, Logrieco A, Ferracane R, Ritieni A
Simultaneous determination of beauvericin, enniatins, and fusaproliferin by high performance liquid chromatography (500 views)
J Agric Food Chem (ISSN: 0021-8561), 2000 Sep; 48(8): 3317-3320.
Impact Factor: 1.56
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Zannetti A, Del Vecchio S, Carriero MV, Fonti R, Franco P, Botti G, D'Aiuto G, Stoppelli MP, Salvatore M
Coordinate up-regulation of Sp1 DNA-binding activity and urokinase receptor expression in breast carcinoma (472 views)
Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 2000 Mar 15; 60(6): 1546-1551.
Impact Factor: 8.46
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Formisano C, Limite G, Lamberti M, Fonti R, Forestieri P
Lymph node mapping and sentinel lymph node biopsy for evaluation of axillary lymph node status in early invasive breast cancer. Our experience (353 views)
Przegl Lek (ISSN: 0033-2240print, 0033-2240linking), 2000; 57Suppl5: 113-115.
Impact Factor: 0
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Camera L, Brunetti A, Romano M, Larobina M, Marano I, Salvatore M
Morphological imaging of thymic disorders (338 views)
Ann Med (ISSN: 0785-3890), 1999 Oct; 31(SUPPL.2): 57-62.
Impact Factor: 2.566
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43 Records (42 excluding Abstracts).
Total impact factor: 178.958 (175.228 excluding Abstracts).
Total 5 year impact factor: 185.028 (180.784 excluding Abstracts).
Total impact factor: 178.958 (175.228 excluding Abstracts).
Total 5 year impact factor: 185.028 (180.784 excluding Abstracts).
545 views. Last view on Saturday 25 March 2023, 10:28:00
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