Carbonic anhydrase inhibitors: the X-ray crystal structure of ethoxzolamide complexed to human isoform II reveals the importance of thr200 and gln92 for obtaining tight-binding inhibitors
Carbonic anhydrase inhibitors: the X-ray crystal structure of ethoxzolamide complexed to human isoform II reveals the importance of thr200 and gln92 for obtaining tight-binding inhibitors(385 views) Di Fiore A, Pedone C, Antel J, Waldeck H, Witte A, Wurl M, Scozzafava A, Supuran CT, De Simone G
Bioorg Med Chem Lett (ISSN: 1464-3405, 0960-894x, 1464-3405electronic), 2008 Apr 15; 18(8): 2669-2674.
Keywords: Carbonic Anhydrase, Ethoxzolamide, Protein Crystallography, Antiglaucoma Agent, Brinzolamide, Carbonate Dehydratase Inhibitor, Dorzolamide, Glutamine, Isoenzyme, Threonine, Animal Cell, Article, Controlled Study, Crystal Structure, Cytosol, Drug Design, Drug Mechanism, Drug Protein Binding, Drug Targeting, Enzyme Inhibition, Mammal, Molecule, Nonhuman, Protein Interaction, X Ray Crystallography, Binding Sites, Carbonic Anhydrase Ii, Carbonic Anhydrase Inhibitors, Catalysis, X-Ray, Models, Molecular Structure,
Affiliations: *** IBB - CNR ***
Istituto di Biostrutture e Bioimmagini-CNR, via Mezzocannone 16, 80134 Napoli, Italy.
Solvay Pharmaceuticals Research Laboratories, Hans Böckler-Allee 20, D-30173 Hannover, Germany
Università degli Studi di Firenze, Laboratorio di Chimica Bioinorganica, Room 188, via della Lastruccia 3, I-50019 Sesto Fiorentino, Firenze, Italy
Universit degli Studi di Firenze, Laboratorio di Chimica Bioinorganica, Room 188, via della Lastruccia 3, I-50019 Sesto Fiorentino, Firenze, Italy
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Carbonic anhydrase inhibitors: the X-ray crystal structure of ethoxzolamide complexed to human isoform II reveals the importance of thr200 and gln92 for obtaining tight-binding inhibitors
Carbonic anhydrase inhibitors: the X-ray crystal structure of ethoxzolamide complexed to human isoform II reveals the importance of thr200 and gln92 for obtaining tight-binding inhibitors
Carbonic anhydrase inhibitors: the X-ray crystal structure of ethoxzolamide complexed to human isoform II reveals the importance of thr200 and gln92 for obtaining tight-binding inhibitors