Gefitinib induction of in vivo detectable signals by Bcl-2/Bcl-xL modulation of inositol trisphosphate receptor type (997 views)
Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 2008 Aug 15; 14(16): 5209-5219.
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Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 6.488, 5-year impact factor: 6.646
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-52649118041&partnerID=40&md5=70b89221a5822c87ccd0a35645c7ed7b
Keywords: Aged, Animals, Apoptosis Drug Effects, Blotting, Western, Carcinoma, Non-Small-Cell Lung Drug Therapy Metabolism, Cell Line, Tumor, Female, Humans, Immunoprecipitation, Inositol 1, 5-Trisphosphate Receptors Metabolism, Lung Neoplasms Drug Therapy Metabolism, Membrane Potential, Mitochondrial Drug Effects, Nude, Middle Aged, Mitochondria Drug Effects, Positron-Emission Tomography, Protein Kinase Inhibitors Pharmacology, Proto-Oncogene Proteins C-Bcl-2 Metabolism, Quinazolines Pharmacology, Radiopharmaceuticals Diagnostic Use, Epidermal Growth Factor Drug Effects Metabolism, Signal Transduction Drug Effects Physiology, Technetium Tc 99m Sestamibi Diagnostic Use, Bcl-X Protein Metabolism, Calcium, Epidermal Growth Factor Receptor Kinase Inhibitor, Erlotinib, Gefitinib, Inositol Trisphosphate, Inositol Trisphosphate Receptor Type 3, Methoxy Isobutyl Isonitrile Technetium Tc 99m, Protein Bcl 2, Unclassified Drug, Diagnostic Agent, 5 Trisphosphate Receptor, Quinazoline Derivative, Radiopharmaceutical Agent, Adult, Animal Experiment, Animal Model, Article, Case Report, Controlled Study, Drug Accumulation, Drug Blood Level, Drug Uptake, Human Cell, In Vivo Study, Lung Cancer, Mouse, Nonhuman, Priority Journal, Protein Expression, Protein Interaction, Protein Phosphorylation, Single Photon Emission Computer Tomography, Lung Non Small Cell Cancer, Lung Tumor, Mitochondrial Membrane Potential, Nude Mouse, Positron Emission Tomography, Tumor Cell Line, Western Blotting, Erlotinib Hydrochloride,
Affiliations:
*** IBB - CNR ***
Institute of Biostructures and Bioimages, National Research Council.
Department of Experimental Oncology, National Cancer InstituteNaples, Italy
Department of Endocrinology and Molecular and Clinical OncologyNaples, Italy
Biomorphological and Functional Sciences, University of Naples Federico IINaples, Italy
References:
Not available.
Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 2008 Aug 15; 14(16): 5209-5219.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 6.488, 5-year impact factor: 6.646
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-52649118041&partnerID=40&md5=70b89221a5822c87ccd0a35645c7ed7b
Keywords: Aged, Animals, Apoptosis Drug Effects, Blotting, Western, Carcinoma, Non-Small-Cell Lung Drug Therapy Metabolism, Cell Line, Tumor, Female, Humans, Immunoprecipitation, Inositol 1, 5-Trisphosphate Receptors Metabolism, Lung Neoplasms Drug Therapy Metabolism, Membrane Potential, Mitochondrial Drug Effects, Nude, Middle Aged, Mitochondria Drug Effects, Positron-Emission Tomography, Protein Kinase Inhibitors Pharmacology, Proto-Oncogene Proteins C-Bcl-2 Metabolism, Quinazolines Pharmacology, Radiopharmaceuticals Diagnostic Use, Epidermal Growth Factor Drug Effects Metabolism, Signal Transduction Drug Effects Physiology, Technetium Tc 99m Sestamibi Diagnostic Use, Bcl-X Protein Metabolism, Calcium, Epidermal Growth Factor Receptor Kinase Inhibitor, Erlotinib, Gefitinib, Inositol Trisphosphate, Inositol Trisphosphate Receptor Type 3, Methoxy Isobutyl Isonitrile Technetium Tc 99m, Protein Bcl 2, Unclassified Drug, Diagnostic Agent, 5 Trisphosphate Receptor, Quinazoline Derivative, Radiopharmaceutical Agent, Adult, Animal Experiment, Animal Model, Article, Case Report, Controlled Study, Drug Accumulation, Drug Blood Level, Drug Uptake, Human Cell, In Vivo Study, Lung Cancer, Mouse, Nonhuman, Priority Journal, Protein Expression, Protein Interaction, Protein Phosphorylation, Single Photon Emission Computer Tomography, Lung Non Small Cell Cancer, Lung Tumor, Mitochondrial Membrane Potential, Nude Mouse, Positron Emission Tomography, Tumor Cell Line, Western Blotting, Erlotinib Hydrochloride,
Affiliations:
*** IBB - CNR ***
Institute of Biostructures and Bioimages, National Research Council.
Department of Experimental Oncology, National Cancer InstituteNaples, Italy
Department of Endocrinology and Molecular and Clinical OncologyNaples, Italy
Biomorphological and Functional Sciences, University of Naples Federico IINaples, Italy
References:
Not available.
Gefitinib induction of in vivo detectable signals by Bcl-2/Bcl-xL modulation of inositol trisphosphate receptor type
Purpose: To test whether epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKI) induce detectable signals in tumor cells and whether such signals may reveal alterations of the apoptotic program. Experimental Design: Tumor cells were treated with gefitinib or erlotinib and tested for their ability to accumulate 99mTc-Sestamibi, a radiolabeled lipophilic cation that localizes in mitochondria. Then we tested whether Bcl-2 and Bcl-xLalter the pattern of drug-dependent tracer accumulation while reducing tumor cell sensitivity to EGFR TKIs. The mechanism underlying the pattern of tracer accumulation was elucidated. Finally, imaging studies were done in animal models and lung cancer patients before and after treatment with EGFR TKIs using single-photon emission computed tomography and 99mTc-Sestamibi. Results: Gefitinib increases accumulation of 99mTc-Sestamibi in Bcl-2-overexpressing cells and enhances the physical interaction of phosphorylated Bcl-2 with inositol trisphosphate receptor type 3 (IP3R3). Consequently, a relative increase of cytosolic and mitochondrial calcium levels occurs. Similarly, lung cancer cells showed an increase of tracer uptake and an enhanced interaction of Bcl-xLwith IP3R3 on exposure to erlotinib concentrations achievable in plasma. The occurrence of these interactions was associated with an enhanced EGFR TKI-induced apoptosis resistance. Posttreatment imaging studies in nude mice bearing control and Bcl-2-overexpressing breast carcinomas showed a high tumor uptake of the tracer whereas baseline studies failed to visualize tumors. Similarly, an enhancement of tracer uptake could be detected in patients with lung cancer treated with erlotinib. Conclusion: EGFR TKIs generate detectable signals by Bcl-2/Bcl-xLmodulation of IP3R3 in tumor cells. © 2008 American Association for Cancer Research.
Purpose: To test whether epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKI) induce detectable signals in tumor cells and whether such signals may reveal alterations of the apoptotic program. Experimental Design: Tumor cells were treated with gefitinib or erlotinib and tested for their ability to accumulate 99mTc-Sestamibi, a radiolabeled lipophilic cation that localizes in mitochondria. Then we tested whether Bcl-2 and Bcl-xLalter the pattern of drug-dependent tracer accumulation while reducing tumor cell sensitivity to EGFR TKIs. The mechanism underlying the pattern of tracer accumulation was elucidated. Finally, imaging studies were done in animal models and lung cancer patients before and after treatment with EGFR TKIs using single-photon emission computed tomography and 99mTc-Sestamibi. Results: Gefitinib increases accumulation of 99mTc-Sestamibi in Bcl-2-overexpressing cells and enhances the physical interaction of phosphorylated Bcl-2 with inositol trisphosphate receptor type 3 (IP3R3). Consequently, a relative increase of cytosolic and mitochondrial calcium levels occurs. Similarly, lung cancer cells showed an increase of tracer uptake and an enhanced interaction of Bcl-xLwith IP3R3 on exposure to erlotinib concentrations achievable in plasma. The occurrence of these interactions was associated with an enhanced EGFR TKI-induced apoptosis resistance. Posttreatment imaging studies in nude mice bearing control and Bcl-2-overexpressing breast carcinomas showed a high tumor uptake of the tracer whereas baseline studies failed to visualize tumors. Similarly, an enhancement of tracer uptake could be detected in patients with lung cancer treated with erlotinib. Conclusion: EGFR TKIs generate detectable signals by Bcl-2/Bcl-xLmodulation of IP3R3 in tumor cells. © 2008 American Association for Cancer Research.
Gefitinib induction of in vivo detectable signals by Bcl-2/Bcl-xL modulation of inositol trisphosphate receptor type
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Gefitinib induction of in vivo detectable signals by Bcl-2/Bcl-xL modulation of inositol trisphosphate receptor type
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Vitagliano L, Fiume G, Scognamiglio PL, Doti N, Cannavo R, Puca A, Pedone C, Scala G, Quinto I, Marasco D
* Structural and functional insights into IkappaB-alpha/HIV-1 Tat interaction (874 views)
Biochimie (ISSN: 0300-9084, 1638-6183, 1638-6183electronic), 2011 Sep; 93(9): 1592-1600.
Impact Factor: 3.022
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Canettieri G, Di Marcotullio L, Greco A, Coni S, Antonucci L, Infante P, Pietrosanti L, De Smaele E, Ferretti E, Miele E, Pelloni M, De Simone G, Pedone E, Gallinari P, Giorgi A, Steinkuhler C, Vitagliano L, Pedone C, Schinin ME, Screpanti I, Gulino A
* Histone deacetylase and Cullin3-REN(KCTD11) ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation (1249 views)
Nature Cell Biol Nature Cell Biology (ISSN: 1476-4679, 1465-7392), 2010 Feb; 12(2): 132-142.
Impact Factor: 19.407
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Vitiello M, Finamore E, Falanga A, Raieta K, Cantisani M, Galdiero F, Pedone C, Galdiero M, Galdiero S
* Viral fusion peptides induce several signal transduction pathway activations that are essential for interleukin-10 and beta-interferon production (755 views)
Intervirology (ISSN: 1423-0100, 0300-5526), 2010; 53(6): 381-389.
Impact Factor: 1.756
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Marasco D, Stilo R, Sandomenico A, Monti SM, Tizzano B, De Capua A, Varricchio E, Liguoro D, Zotti T, Formisano S, Ruvo M, Vito P
* Generation And Functional Characterization Of A Bcl10-Inhibitory Peptide That Represses Nf-Kappa B Activation (895 views)
Biochem J (ISSN: 0264-6021, 1470-8728electronic, 0264-6021linking), 2009 Sep 15; 422(3): 553-561.
Impact Factor: 5.155
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Carriero MV, Longanesi-cattani I, Bifulco K, Maglio O, Lista L, Barbieri A, Votta G, Masucci MT, Arra C, Franco R, De Rosa M, Stoppelli MP, Pavone V
* Structure-based design of an urokinase-type plasminogen activator receptor-derived peptide inhibiting cell migration and lung metastasis (897 views)
Mol Cancer Ther (ISSN: 1535-7163, 1538-8514electronic, 1535-7163linking), 2009 Sep; 8(9): 2708-2717.
Impact Factor: 4.953
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Copani A, Hoozemans JJM, Caraci F, Calafiore M, Van Haastert ES, Veerhuis R, Rozemuller AJM, Aronica E, Sortino MA, Nicoletti F
* Dna Polymerase-Beta Is Expressed Early In Neurons Of Alzheimer'S Disease Brain And Is Loaded Into Dna Replication Forks In Neurons Challenged With Beta-Amyloid (1029 views)
J Neurosci (ISSN: 0270-6474, 0361-803x, 1529-2401), 2006; 26(43): 10949-10957.
Impact Factor: 2.117
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Cardone L, de Cristofaro T, Affaitati A, Garbi C, Ginsberg MD, Saviano M, Varrone S, Rubin CS, Gottesman ME, Avvedimento EV, Feliciello A
* A-kinase anchor protein 84/121 are targeted to mitochondria and mitotic spindles by overlapping amino-terminal motifs (1084 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2002 Jul 12; 320(3): 663-675.
Impact Factor: 5.359
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Vitiello M, Finamore E, Falanga A, Raieta K, Cantisani M, Galdiero F, Pedone C, Galdiero M, Galdiero S
* Fusion in Coq (766 views)
Lecture Notes In Computer Science (ISSN: 0302-9743, 0302-974335404636319783540463634, 0302-974335402975459783540297543), 2001; 2178LNCS: 583-596.
Impact Factor: 0.415
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Carriero MV, Del Vecchio S, Franco P, Potena MI, Chiaradonna F, Botti G, Stoppelli MP, Salvatore M
Vitronectin binding to urokinase receptor in human breast cancer (768 views)
Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 1997 Sep; 3(8): 1299-1308.
Impact Factor: 3.419
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Carriero MV, Franco P, Del Vecchio S, Massa O, Botti G, D'Aiuto G, Stoppelli MP, Salvatore M
Tissue distribution of soluble and receptor-bound urokinase in human breast cancer using a panel of monoclonal antibodies (845 views)
Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 1994 Oct 15; 54(20): 5445-5454.
Impact Factor: 8.426
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FRITTITTA L, VIGNERI R, PAPA V, GOLDFINE I, GRASSO G, TRISCHITTA V
Structural and functional studies of insulin receptors in human breast cancer (661 views)
Breast Cancer Res Tr Kluwer Academic Publishers (ISSN: 0167-6806), 1993; 25(1): 73-82.
Impact Factor: 2.43
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26 Records (24 excluding Abstracts).
Total impact factor: 135.977 (130.165 excluding Abstracts).
Total 5 year impact factor: 143.269 (137.334 excluding Abstracts).
Total impact factor: 135.977 (130.165 excluding Abstracts).
Total 5 year impact factor: 143.269 (137.334 excluding Abstracts).
997 views. Last view on Tuesday 15 April 2025, 3:24:58
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