Gefitinib induction of in vivo detectable signals by Bcl-2/Bcl-xL modulation of inositol trisphosphate receptor type (537 views)
Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 2008 Aug 15; 14(16): 5209-5219.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 6.488, 5-year impact factor: 6.646
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-52649118041&partnerID=40&md5=70b89221a5822c87ccd0a35645c7ed7b
Keywords: Aged, Animals, Apoptosis Drug Effects, Blotting, Western, Carcinoma, Non-Small-Cell Lung Drug Therapy Metabolism, Cell Line, Tumor, Female, Humans, Immunoprecipitation, Inositol 1, 5-Trisphosphate Receptors Metabolism, Lung Neoplasms Drug Therapy Metabolism, Membrane Potential, Mitochondrial Drug Effects, Nude, Middle Aged, Mitochondria Drug Effects, Positron-Emission Tomography, Protein Kinase Inhibitors Pharmacology, Proto-Oncogene Proteins C-Bcl-2 Metabolism, Quinazolines Pharmacology, Radiopharmaceuticals Diagnostic Use, Epidermal Growth Factor Drug Effects Metabolism, Signal Transduction Drug Effects Physiology, Technetium Tc 99m Sestamibi Diagnostic Use, Bcl-X Protein Metabolism, Calcium, Epidermal Growth Factor Receptor Kinase Inhibitor, Erlotinib, Gefitinib, Inositol Trisphosphate, Inositol Trisphosphate Receptor Type 3, Methoxy Isobutyl Isonitrile Technetium Tc 99m, Protein Bcl 2, Unclassified Drug, Diagnostic Agent, 5 Trisphosphate Receptor, Quinazoline Derivative, Radiopharmaceutical Agent, Adult, Animal Experiment, Animal Model, Article, Case Report, Controlled Study, Drug Accumulation, Drug Blood Level, Drug Uptake, Human Cell, In Vivo Study, Lung Cancer, Mouse, Nonhuman, Priority Journal, Protein Expression, Protein Interaction, Protein Phosphorylation, Single Photon Emission Computer Tomography, Lung Non Small Cell Cancer, Lung Tumor, Mitochondrial Membrane Potential, Nude Mouse, Positron Emission Tomography, Tumor Cell Line, Western Blotting, Erlotinib Hydrochloride,
Affiliations:
*** IBB - CNR ***
Institute of Biostructures and Bioimages, National Research Council.
Department of Experimental Oncology, National Cancer InstituteNaples, Italy
Department of Endocrinology and Molecular and Clinical OncologyNaples, Italy
Biomorphological and Functional Sciences, University of Naples Federico IINaples, Italy
References:
Ono, M., Kuwano, M., Molecular mechanisms of epidermal growth factor receptor (EGFR) activation and response to gefitinib and other EGFR-targeting drugs (2006) Clin Cancer Res, 12, pp. 7242-725
Herbst, R. S., Fukuoka, M., Baselga, J., Gefitinib-novel targeted approach to treating cancer (2004) Nat Rev Cancer, 4, pp. 956-965
Brehmer, D., Greff, Z., Godl, K., Cellular targets of gefitinib (2005) Cancer Res, 65, pp. 379-382
Sun, S., Schiller, J. H., Spinola, M., Minna, J. D., New molec-ularly targeted therapies for lung cancer (2007) J Clin Invest, 117, pp. 2740-2750
Johnson, B. E., Janne, P. A., Epidermal growth factor receptor mutations in patients with non-small cell lung cancer (2005) Cancer Res, 65, pp. 7525-7529
Bianco, R., Melisi, D., Ciardiello, F., Tortora, G., Key cancer cell signal transduction pathways as therapeutic targets (2006) Eur J Cancer, 42, pp. 290-294
Lynch, T. J., Bell, D. W., Sordella, R., Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib (2004) N Engl J Med, 350, pp. 2129-2139
Paez, J. G., Janne, P. A., Lee, J. C., EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy (2004) Science, 304, pp. 1497-1500
Engelman, J. A., Janne, P. A., Mermel, C., ErbB-3 mediates phosphoinositide 3-kinase activity in gefiti-nib-sensitive non-small cell lung cancer cell lines (2005) Proc Natl Acad Sci U S A, 102, pp. 3788-3793
Eberhard, D. A., Johnson, B. E., Amler, L. C., Mutations in the epidermal growth factor receptor and in KRAS are predictive and prognostic indicators in patients with non-small-cell lung cancer treated with chemotherapy alone and in combination with erlotinib (2005) J Clin Oncol, 23, pp. 5900-5909
Sordella, R., Bell, D. W., Haber, D. A., Settleman, J., Gefiti-nib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways (2004) Science, 305, pp. 1163-1167
Weinstein, I. B., Cancer. Addiction to oncogenes-the Achilles heal of cancer (2002) Science, 297, pp. 63-64
Costa, D. B., Halmos, B., Kumar, A., BIM mediates EGFR tyrosine kinase inhibitor-induced apoptosis in lung cancers with oncogenic EGFR mutations (2007) PLoS Med, 4, pp. 1669-1679
Kuroda, J., Puthalakath, H., Cragg, M. S., Bim and Bad mediate imatinib-induced killing of Bcr/Abl+ leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic (2006) Proc Natl Acad Sci USA, 103, pp. 14907-14912
Pao, W., Miller, V. A., Politi, K. A., Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain (2005) PLoS Med, 2, pp. e73
Kwak, E. L., Sordella, R., Bell, D. W., Irreversible inhibitors of the EGF receptor may circumvent acquired resistance to gefitinib (2005) Proc Natl Acad Sci U S A, 102, pp. 7665-7670
Kobayashi, S., Boggon, T. J., Dayaram, T., EGFR mutation and resistance of non-small-cell lung cancer to gefitinib (2005) N Engl J Med, 352, pp. 786-792
Engelman, J. A., Zejnullahu, K., Mitsudomi, T., MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling (2007) Science, 316, pp. 1039-1043
Bean, J., Brennan, C., Shih, J. Y., MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib (2007) Proc Natl Acad Sci U S A, 104, pp. 20932-20937
Deng, J., Shimamura, T., Perera, S., Proapoptotic BH3-only BCL-2 family protein BIM connects death signaling from epidermal growth factor receptor inhibition to the mitochondrion (2007) Cancer Res, 67, pp. 11867-11875
Reed, J. C., Proapoptotic multidomain Bcl-2/Bax- family proteins: Mechanisms, physiological roles, and therapeutic opportunities (2006) Cell Death Differ, 13, pp. 1378-1386
Bassik, M. C., Scorrano, L., Oakes, S. A., Pozzan, T., Korsmeyer, S. J., Phosphorylation of BCL-2 regulates ER Ca2+ homeostasis and apoptosis (2004) EMBO J, 23, pp. 1207-1216
Oakes, S. A., Scorrano, L., Opferman, J. T., Proapoptotic BAX and BAK regulate the type 1 inositol trisphos-phate receptor and calcium leak from the endoplasmic reticulum Proc Natl Acad Sci, USA2005 (102), pp. 105-110
Chen, R., Valencia, I., Zhong, F., Bcl-2 functionally interacts with inositol 1, 4, 5-trisphosphate receptors to regulate calcium release from the ER in response to inositol 1, 4, 5-trisphosphate (2004) J Cell Biol, 166, pp. 193-203
Danial, N. N., Korsmeyer, S. J., Cell death: Critical control points (2004) Cell, 116, pp. 205-219
Li, C., Wang, X., Vais, H., Thompson, C. B., Foskett, J. K., White, C., Apoptosis regulation by Bcl-x (L) modulation of mammalian inositol 1, 4, 5-trisphosphate receptor channel isoform gating (2007) Proc Natl Acad Sci USA, 104, pp. 12565-12570
Piwnica-Worms, D., Kronauge, J. F., Chiu, M. L., Uptake and retention of hexakis (2-methoxyisobutyl isonitrile) technetium (l) in cultured chick myocardial cells. Mitochondrial and plasma membrane potential dependence (1990) Circulation, 82, pp. 1826-1838
Aloi, L., Zannetti, A., Caraco, C., Del Vecchio, S., Salvatore, M., Bcl-2 overexpression prevents 99mTc-MIBI uptake in breast cancer cell lines (2004) Eur J Nucl Med Mol Imaging, 31, pp. 521-527
Del Vecchio, S., Zannetti, A., Aloj, L., Caraco, C., Ciarmiello, A., Salvatore, M., Inhibition of early 99mTc-MIBI uptake by Bcl-2 anti-apoptotic protein overexpression in untreated breast carcinoma (2003) Eur J Nucl Med Mol Imaging, 30, pp. 879-887
Zannetti, A., Del Vecchio, S., Carriero, M. V., Coordinate up-regulation of Sp1 DNA-binding activity and urokinase receptor expression in breast carcinoma (2000) Cancer Res, 60, pp. 1546-1551
Yang, C. H., Huang, C. J., Yang, C. S., Gefitinib reverses chemotherapy resistance in gefitinib-insensi-tive multidrug resistant cancer cells expressing ATP-binding cassette family protein (2005) Cancer Res, 65, pp. 6943-6949
Elkind, N. B., Szentpetery, Z., Apati, A., Multidrug transporter ABCG2 prevents tumor cell death induced by the epidermal growth factor receptor inhibitor Iressa (ZD1839, Gefitinib) (2005) Cancer Res, 65, pp. 1770-1777
Nakamura, Y., Oka, M., Soda, H., Gefitinib ("Iressa", ZD1839), an epidermal growth factor receptor tyrosine kinase inhibitor, reverses breast cancer resistance protein/ABCG2-mediated drug resistance (2005) Cancer Res, 65, pp. 1541-1546
Wang, H. G., Pathan, N., Ethell, I. M., Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD (1999) Science, 284, pp. 339-343
Shibasaki, F., Kondo, E., Akagi, T., McKeon, F., Suppression of signalling through transcription factor NF-AT by interactions between calcineurin and Bcl-2 (1997) Nature, 386, pp. 728-731
Gong, Y., Somwar, R., Politi, K., Induction of BIM is essential for apoptosis triggered by EGFR kinase inhibitors in mutant EGFR-dependent lung adenocarcinomas (2007) PLoS Med, 4, pp. e294
White, C., Li, C., Yang, J., The endoplasmic reticulum gateway to apoptosis by Bcl-X (L) modulation of the lnsP3R (2005) Nat Cell Biol, 7, pp. 1021-1028
Sharma, S. V., Bell, D. W., Settleman, J., Haber, D. A., Epidermal growth factor receptor mutations in lung cancer (2007) Nat Rev Cancer, 7, pp. 169-181
Herbst, R.S., Fukuoka, M., Baselga, J., Gefitinib-novel targeted approach to treating cancer (2004) Nat Rev Cancer, 4, pp. 956-965
Johnson, B.E., Janne, P.A., Epidermal growth factor receptor mutations in patients with non-small cell lung cancer (2005) Cancer Res, 65, pp. 7525-7529
Lynch, T.J., Bell, D.W., Sordella, R., Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib (2004) N Engl J Med, 350, pp. 2129-2139
Paez, J.G., Janne, P.A., Lee, J.C., EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy (2004) Science, 304, pp. 1497-1500
Engelman, J.A., Janne, P.A., Mermel, C., ErbB-3 mediates phosphoinositide 3-kinase activity in gefiti-nib-sensitive non-small cell lung cancer cell lines (2005) Proc Natl Acad Sci U S A, 102, pp. 3788-3793
Eberhard, D.A., Johnson, B.E., Amler, L.C., Mutations in the epidermal growth factor receptor and in KRAS are predictive and prognostic indicators in patients with non-small-cell lung cancer treated with chemotherapy alone and in combination with erlotinib (2005) J Clin Oncol, 23, pp. 5900-5909
Weinstein, I.B., Cancer. Addiction to oncogenes-the Achilles heal of cancer (2002) Science, 297, pp. 63-64
Costa, D.B., Halmos, B., Kumar, A., BIM mediates EGFR tyrosine kinase inhibitor-induced apoptosis in lung cancers with oncogenic EGFR mutations (2007) PLoS Med, 4, pp. 1669-1679
Kwak, E.L., Sordella, R., Bell, D.W., Irreversible inhibitors of the EGF receptor may circumvent acquired resistance to gefitinib (2005) Proc Natl Acad Sci U S A, 102, pp. 7665-7670
Engelman, J.A., Zejnullahu, K., Mitsudomi, T., MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling (2007) Science, 316, pp. 1039-1043
Reed, J.C., Proapoptotic multidomain Bcl-2/Bax- family proteins: Mechanisms, physiological roles, and therapeutic opportunities (2006) Cell Death Differ, 13, pp. 1378-1386
Bassik, M.C., Scorrano, L., Oakes, S.A., Pozzan, T., Korsmeyer, S.J., Phosphorylation of BCL-2 regulates ER Ca2+ homeostasis and apoptosis (2004) EMBO J, 23, pp. 1207-1216
Oakes, S.A., Scorrano, L., Opferman, J.T., Proapoptotic BAX and BAK regulate the type 1 inositol trisphos-phate receptor and calcium leak from the endoplasmic reticulum Proc Natl Acad Sci, USA2005 (102), pp. 105-110
Danial, N.N., Korsmeyer, S.J., Cell death: Critical control points (2004) Cell, 116, pp. 205-219
Yang, C.H., Huang, C.J., Yang, C.S., Gefitinib reverses chemotherapy resistance in gefitinib-insensi-tive multidrug resistant cancer cells expressing ATP-binding cassette family protein (2005) Cancer Res, 65, pp. 6943-6949
Elkind, N.B., Szentpetery, Z., Apati, A., Multidrug transporter ABCG2 prevents tumor cell death induced by the epidermal growth factor receptor inhibitor Iressa (ZD1839, Gefitinib) (2005) Cancer Res, 65, pp. 1770-1777
Wang, H.G., Pathan, N., Ethell, I.M., Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD (1999) Science, 284, pp. 339-343
Sharma, S.V., Bell, D.W., Settleman, J., Haber, D.A., Epidermal growth factor receptor mutations in lung cancer (2007) Nat Rev Cancer, 7, pp. 169-181
Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 2008 Aug 15; 14(16): 5209-5219.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 6.488, 5-year impact factor: 6.646
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-52649118041&partnerID=40&md5=70b89221a5822c87ccd0a35645c7ed7b
Keywords: Aged, Animals, Apoptosis Drug Effects, Blotting, Western, Carcinoma, Non-Small-Cell Lung Drug Therapy Metabolism, Cell Line, Tumor, Female, Humans, Immunoprecipitation, Inositol 1, 5-Trisphosphate Receptors Metabolism, Lung Neoplasms Drug Therapy Metabolism, Membrane Potential, Mitochondrial Drug Effects, Nude, Middle Aged, Mitochondria Drug Effects, Positron-Emission Tomography, Protein Kinase Inhibitors Pharmacology, Proto-Oncogene Proteins C-Bcl-2 Metabolism, Quinazolines Pharmacology, Radiopharmaceuticals Diagnostic Use, Epidermal Growth Factor Drug Effects Metabolism, Signal Transduction Drug Effects Physiology, Technetium Tc 99m Sestamibi Diagnostic Use, Bcl-X Protein Metabolism, Calcium, Epidermal Growth Factor Receptor Kinase Inhibitor, Erlotinib, Gefitinib, Inositol Trisphosphate, Inositol Trisphosphate Receptor Type 3, Methoxy Isobutyl Isonitrile Technetium Tc 99m, Protein Bcl 2, Unclassified Drug, Diagnostic Agent, 5 Trisphosphate Receptor, Quinazoline Derivative, Radiopharmaceutical Agent, Adult, Animal Experiment, Animal Model, Article, Case Report, Controlled Study, Drug Accumulation, Drug Blood Level, Drug Uptake, Human Cell, In Vivo Study, Lung Cancer, Mouse, Nonhuman, Priority Journal, Protein Expression, Protein Interaction, Protein Phosphorylation, Single Photon Emission Computer Tomography, Lung Non Small Cell Cancer, Lung Tumor, Mitochondrial Membrane Potential, Nude Mouse, Positron Emission Tomography, Tumor Cell Line, Western Blotting, Erlotinib Hydrochloride,
Affiliations:
*** IBB - CNR ***
Institute of Biostructures and Bioimages, National Research Council.
Department of Experimental Oncology, National Cancer InstituteNaples, Italy
Department of Endocrinology and Molecular and Clinical OncologyNaples, Italy
Biomorphological and Functional Sciences, University of Naples Federico IINaples, Italy
References:
Ono, M., Kuwano, M., Molecular mechanisms of epidermal growth factor receptor (EGFR) activation and response to gefitinib and other EGFR-targeting drugs (2006) Clin Cancer Res, 12, pp. 7242-725
Herbst, R. S., Fukuoka, M., Baselga, J., Gefitinib-novel targeted approach to treating cancer (2004) Nat Rev Cancer, 4, pp. 956-965
Brehmer, D., Greff, Z., Godl, K., Cellular targets of gefitinib (2005) Cancer Res, 65, pp. 379-382
Sun, S., Schiller, J. H., Spinola, M., Minna, J. D., New molec-ularly targeted therapies for lung cancer (2007) J Clin Invest, 117, pp. 2740-2750
Johnson, B. E., Janne, P. A., Epidermal growth factor receptor mutations in patients with non-small cell lung cancer (2005) Cancer Res, 65, pp. 7525-7529
Bianco, R., Melisi, D., Ciardiello, F., Tortora, G., Key cancer cell signal transduction pathways as therapeutic targets (2006) Eur J Cancer, 42, pp. 290-294
Lynch, T. J., Bell, D. W., Sordella, R., Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib (2004) N Engl J Med, 350, pp. 2129-2139
Paez, J. G., Janne, P. A., Lee, J. C., EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy (2004) Science, 304, pp. 1497-1500
Engelman, J. A., Janne, P. A., Mermel, C., ErbB-3 mediates phosphoinositide 3-kinase activity in gefiti-nib-sensitive non-small cell lung cancer cell lines (2005) Proc Natl Acad Sci U S A, 102, pp. 3788-3793
Eberhard, D. A., Johnson, B. E., Amler, L. C., Mutations in the epidermal growth factor receptor and in KRAS are predictive and prognostic indicators in patients with non-small-cell lung cancer treated with chemotherapy alone and in combination with erlotinib (2005) J Clin Oncol, 23, pp. 5900-5909
Sordella, R., Bell, D. W., Haber, D. A., Settleman, J., Gefiti-nib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways (2004) Science, 305, pp. 1163-1167
Weinstein, I. B., Cancer. Addiction to oncogenes-the Achilles heal of cancer (2002) Science, 297, pp. 63-64
Costa, D. B., Halmos, B., Kumar, A., BIM mediates EGFR tyrosine kinase inhibitor-induced apoptosis in lung cancers with oncogenic EGFR mutations (2007) PLoS Med, 4, pp. 1669-1679
Kuroda, J., Puthalakath, H., Cragg, M. S., Bim and Bad mediate imatinib-induced killing of Bcr/Abl+ leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic (2006) Proc Natl Acad Sci USA, 103, pp. 14907-14912
Pao, W., Miller, V. A., Politi, K. A., Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain (2005) PLoS Med, 2, pp. e73
Kwak, E. L., Sordella, R., Bell, D. W., Irreversible inhibitors of the EGF receptor may circumvent acquired resistance to gefitinib (2005) Proc Natl Acad Sci U S A, 102, pp. 7665-7670
Kobayashi, S., Boggon, T. J., Dayaram, T., EGFR mutation and resistance of non-small-cell lung cancer to gefitinib (2005) N Engl J Med, 352, pp. 786-792
Engelman, J. A., Zejnullahu, K., Mitsudomi, T., MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling (2007) Science, 316, pp. 1039-1043
Bean, J., Brennan, C., Shih, J. Y., MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib (2007) Proc Natl Acad Sci U S A, 104, pp. 20932-20937
Deng, J., Shimamura, T., Perera, S., Proapoptotic BH3-only BCL-2 family protein BIM connects death signaling from epidermal growth factor receptor inhibition to the mitochondrion (2007) Cancer Res, 67, pp. 11867-11875
Reed, J. C., Proapoptotic multidomain Bcl-2/Bax- family proteins: Mechanisms, physiological roles, and therapeutic opportunities (2006) Cell Death Differ, 13, pp. 1378-1386
Bassik, M. C., Scorrano, L., Oakes, S. A., Pozzan, T., Korsmeyer, S. J., Phosphorylation of BCL-2 regulates ER Ca2+ homeostasis and apoptosis (2004) EMBO J, 23, pp. 1207-1216
Oakes, S. A., Scorrano, L., Opferman, J. T., Proapoptotic BAX and BAK regulate the type 1 inositol trisphos-phate receptor and calcium leak from the endoplasmic reticulum Proc Natl Acad Sci, USA2005 (102), pp. 105-110
Chen, R., Valencia, I., Zhong, F., Bcl-2 functionally interacts with inositol 1, 4, 5-trisphosphate receptors to regulate calcium release from the ER in response to inositol 1, 4, 5-trisphosphate (2004) J Cell Biol, 166, pp. 193-203
Danial, N. N., Korsmeyer, S. J., Cell death: Critical control points (2004) Cell, 116, pp. 205-219
Li, C., Wang, X., Vais, H., Thompson, C. B., Foskett, J. K., White, C., Apoptosis regulation by Bcl-x (L) modulation of mammalian inositol 1, 4, 5-trisphosphate receptor channel isoform gating (2007) Proc Natl Acad Sci USA, 104, pp. 12565-12570
Piwnica-Worms, D., Kronauge, J. F., Chiu, M. L., Uptake and retention of hexakis (2-methoxyisobutyl isonitrile) technetium (l) in cultured chick myocardial cells. Mitochondrial and plasma membrane potential dependence (1990) Circulation, 82, pp. 1826-1838
Aloi, L., Zannetti, A., Caraco, C., Del Vecchio, S., Salvatore, M., Bcl-2 overexpression prevents 99mTc-MIBI uptake in breast cancer cell lines (2004) Eur J Nucl Med Mol Imaging, 31, pp. 521-527
Del Vecchio, S., Zannetti, A., Aloj, L., Caraco, C., Ciarmiello, A., Salvatore, M., Inhibition of early 99mTc-MIBI uptake by Bcl-2 anti-apoptotic protein overexpression in untreated breast carcinoma (2003) Eur J Nucl Med Mol Imaging, 30, pp. 879-887
Zannetti, A., Del Vecchio, S., Carriero, M. V., Coordinate up-regulation of Sp1 DNA-binding activity and urokinase receptor expression in breast carcinoma (2000) Cancer Res, 60, pp. 1546-1551
Yang, C. H., Huang, C. J., Yang, C. S., Gefitinib reverses chemotherapy resistance in gefitinib-insensi-tive multidrug resistant cancer cells expressing ATP-binding cassette family protein (2005) Cancer Res, 65, pp. 6943-6949
Elkind, N. B., Szentpetery, Z., Apati, A., Multidrug transporter ABCG2 prevents tumor cell death induced by the epidermal growth factor receptor inhibitor Iressa (ZD1839, Gefitinib) (2005) Cancer Res, 65, pp. 1770-1777
Nakamura, Y., Oka, M., Soda, H., Gefitinib ("Iressa", ZD1839), an epidermal growth factor receptor tyrosine kinase inhibitor, reverses breast cancer resistance protein/ABCG2-mediated drug resistance (2005) Cancer Res, 65, pp. 1541-1546
Wang, H. G., Pathan, N., Ethell, I. M., Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD (1999) Science, 284, pp. 339-343
Shibasaki, F., Kondo, E., Akagi, T., McKeon, F., Suppression of signalling through transcription factor NF-AT by interactions between calcineurin and Bcl-2 (1997) Nature, 386, pp. 728-731
Gong, Y., Somwar, R., Politi, K., Induction of BIM is essential for apoptosis triggered by EGFR kinase inhibitors in mutant EGFR-dependent lung adenocarcinomas (2007) PLoS Med, 4, pp. e294
White, C., Li, C., Yang, J., The endoplasmic reticulum gateway to apoptosis by Bcl-X (L) modulation of the lnsP3R (2005) Nat Cell Biol, 7, pp. 1021-1028
Sharma, S. V., Bell, D. W., Settleman, J., Haber, D. A., Epidermal growth factor receptor mutations in lung cancer (2007) Nat Rev Cancer, 7, pp. 169-181
Herbst, R.S., Fukuoka, M., Baselga, J., Gefitinib-novel targeted approach to treating cancer (2004) Nat Rev Cancer, 4, pp. 956-965
Johnson, B.E., Janne, P.A., Epidermal growth factor receptor mutations in patients with non-small cell lung cancer (2005) Cancer Res, 65, pp. 7525-7529
Lynch, T.J., Bell, D.W., Sordella, R., Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib (2004) N Engl J Med, 350, pp. 2129-2139
Paez, J.G., Janne, P.A., Lee, J.C., EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy (2004) Science, 304, pp. 1497-1500
Engelman, J.A., Janne, P.A., Mermel, C., ErbB-3 mediates phosphoinositide 3-kinase activity in gefiti-nib-sensitive non-small cell lung cancer cell lines (2005) Proc Natl Acad Sci U S A, 102, pp. 3788-3793
Eberhard, D.A., Johnson, B.E., Amler, L.C., Mutations in the epidermal growth factor receptor and in KRAS are predictive and prognostic indicators in patients with non-small-cell lung cancer treated with chemotherapy alone and in combination with erlotinib (2005) J Clin Oncol, 23, pp. 5900-5909
Weinstein, I.B., Cancer. Addiction to oncogenes-the Achilles heal of cancer (2002) Science, 297, pp. 63-64
Costa, D.B., Halmos, B., Kumar, A., BIM mediates EGFR tyrosine kinase inhibitor-induced apoptosis in lung cancers with oncogenic EGFR mutations (2007) PLoS Med, 4, pp. 1669-1679
Kwak, E.L., Sordella, R., Bell, D.W., Irreversible inhibitors of the EGF receptor may circumvent acquired resistance to gefitinib (2005) Proc Natl Acad Sci U S A, 102, pp. 7665-7670
Engelman, J.A., Zejnullahu, K., Mitsudomi, T., MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling (2007) Science, 316, pp. 1039-1043
Reed, J.C., Proapoptotic multidomain Bcl-2/Bax- family proteins: Mechanisms, physiological roles, and therapeutic opportunities (2006) Cell Death Differ, 13, pp. 1378-1386
Bassik, M.C., Scorrano, L., Oakes, S.A., Pozzan, T., Korsmeyer, S.J., Phosphorylation of BCL-2 regulates ER Ca2+ homeostasis and apoptosis (2004) EMBO J, 23, pp. 1207-1216
Oakes, S.A., Scorrano, L., Opferman, J.T., Proapoptotic BAX and BAK regulate the type 1 inositol trisphos-phate receptor and calcium leak from the endoplasmic reticulum Proc Natl Acad Sci, USA2005 (102), pp. 105-110
Danial, N.N., Korsmeyer, S.J., Cell death: Critical control points (2004) Cell, 116, pp. 205-219
Yang, C.H., Huang, C.J., Yang, C.S., Gefitinib reverses chemotherapy resistance in gefitinib-insensi-tive multidrug resistant cancer cells expressing ATP-binding cassette family protein (2005) Cancer Res, 65, pp. 6943-6949
Elkind, N.B., Szentpetery, Z., Apati, A., Multidrug transporter ABCG2 prevents tumor cell death induced by the epidermal growth factor receptor inhibitor Iressa (ZD1839, Gefitinib) (2005) Cancer Res, 65, pp. 1770-1777
Wang, H.G., Pathan, N., Ethell, I.M., Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD (1999) Science, 284, pp. 339-343
Sharma, S.V., Bell, D.W., Settleman, J., Haber, D.A., Epidermal growth factor receptor mutations in lung cancer (2007) Nat Rev Cancer, 7, pp. 169-181
Gefitinib induction of in vivo detectable signals by Bcl-2/Bcl-xL modulation of inositol trisphosphate receptor type
Purpose: To test whether epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKI) induce detectable signals in tumor cells and whether such signals may reveal alterations of the apoptotic program. Experimental Design: Tumor cells were treated with gefitinib or erlotinib and tested for their ability to accumulate 99mTc-Sestamibi, a radiolabeled lipophilic cation that localizes in mitochondria. Then we tested whether Bcl-2 and Bcl-xLalter the pattern of drug-dependent tracer accumulation while reducing tumor cell sensitivity to EGFR TKIs. The mechanism underlying the pattern of tracer accumulation was elucidated. Finally, imaging studies were done in animal models and lung cancer patients before and after treatment with EGFR TKIs using single-photon emission computed tomography and 99mTc-Sestamibi. Results: Gefitinib increases accumulation of 99mTc-Sestamibi in Bcl-2-overexpressing cells and enhances the physical interaction of phosphorylated Bcl-2 with inositol trisphosphate receptor type 3 (IP3R3). Consequently, a relative increase of cytosolic and mitochondrial calcium levels occurs. Similarly, lung cancer cells showed an increase of tracer uptake and an enhanced interaction of Bcl-xLwith IP3R3 on exposure to erlotinib concentrations achievable in plasma. The occurrence of these interactions was associated with an enhanced EGFR TKI-induced apoptosis resistance. Posttreatment imaging studies in nude mice bearing control and Bcl-2-overexpressing breast carcinomas showed a high tumor uptake of the tracer whereas baseline studies failed to visualize tumors. Similarly, an enhancement of tracer uptake could be detected in patients with lung cancer treated with erlotinib. Conclusion: EGFR TKIs generate detectable signals by Bcl-2/Bcl-xLmodulation of IP3R3 in tumor cells. © 2008 American Association for Cancer Research.
Purpose: To test whether epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKI) induce detectable signals in tumor cells and whether such signals may reveal alterations of the apoptotic program. Experimental Design: Tumor cells were treated with gefitinib or erlotinib and tested for their ability to accumulate 99mTc-Sestamibi, a radiolabeled lipophilic cation that localizes in mitochondria. Then we tested whether Bcl-2 and Bcl-xLalter the pattern of drug-dependent tracer accumulation while reducing tumor cell sensitivity to EGFR TKIs. The mechanism underlying the pattern of tracer accumulation was elucidated. Finally, imaging studies were done in animal models and lung cancer patients before and after treatment with EGFR TKIs using single-photon emission computed tomography and 99mTc-Sestamibi. Results: Gefitinib increases accumulation of 99mTc-Sestamibi in Bcl-2-overexpressing cells and enhances the physical interaction of phosphorylated Bcl-2 with inositol trisphosphate receptor type 3 (IP3R3). Consequently, a relative increase of cytosolic and mitochondrial calcium levels occurs. Similarly, lung cancer cells showed an increase of tracer uptake and an enhanced interaction of Bcl-xLwith IP3R3 on exposure to erlotinib concentrations achievable in plasma. The occurrence of these interactions was associated with an enhanced EGFR TKI-induced apoptosis resistance. Posttreatment imaging studies in nude mice bearing control and Bcl-2-overexpressing breast carcinomas showed a high tumor uptake of the tracer whereas baseline studies failed to visualize tumors. Similarly, an enhancement of tracer uptake could be detected in patients with lung cancer treated with erlotinib. Conclusion: EGFR TKIs generate detectable signals by Bcl-2/Bcl-xLmodulation of IP3R3 in tumor cells. © 2008 American Association for Cancer Research.
Gefitinib induction of in vivo detectable signals by Bcl-2/Bcl-xL modulation of inositol trisphosphate receptor type
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Gefitinib induction of in vivo detectable signals by Bcl-2/Bcl-xL modulation of inositol trisphosphate receptor type
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Cardone L, de Cristofaro T, Affaitati A, Garbi C, Ginsberg MD, Saviano M, Varrone S, Rubin CS, Gottesman ME, Avvedimento EV, Feliciello A
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Carriero MV, Del Vecchio S, Franco P, Potena MI, Chiaradonna F, Botti G, Stoppelli MP, Salvatore M
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FRITTITTA L, VIGNERI R, PAPA V, GOLDFINE I, GRASSO G, TRISCHITTA V
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* Design, Optimization, and Structural Characterization of an Apoptosis-Inducing Factor Peptide Targeting Human Cyclophilin A to Inhibit Apoptosis Inducing Factor-Mediated Cell Death (11 views)
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Impact Factor:
View Export to BibTeX Export to EndNote
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Impact Factor: 3.345
View Export to BibTeX Export to EndNote
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De Rosa V, Iommelli F, Monti M, Fonti R, Votta G, Stoppelli MP, Del Vecchio S
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Impact Factor: 8.738
View Export to BibTeX Export to EndNote
Hangen E, Féraud O, Lachkar S, Mou H, Doti N, Fimia GM, Lam N-V, Zhu C, Godin I, Muller K, Chatzi A, Nuebel E, Ciccosanti F, Flamant S, Bénit P, Perfettini J-L, Sauvat A, Bennaceur-Griscelli A, Ser-Le Roux K, Gonin P, Tokatlidis K, Rustin P, Piacentini M, Ruvo M, Blomgren K, Kroemer G, Modjtahedi N
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Impact Factor: 13.958
View Export to BibTeX Export to EndNote
Oppermann S, Schrader FC, Elsasser K, Dolga AM, Kraus AL, Doti N, Wegscheid-Gerlach C, Schlitzer M, Culmsee C
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Impact Factor: 3.972
View Export to BibTeX Export to EndNote
Formisano L, Nappi L, Rosa R, Marciano R, D'Amato C, D'Amato V, Damiano V, Raimondo L, Iommelli F, Scorziello A, Troncone G, Veneziani BM, Parsons SJ, De Placido S, Bianco R
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Impact Factor: 0.635
View Export to BibTeX Export to EndNote
Severino V, Alessio N, Farina A, Sandomenico A, Cipollaro M, Peluso G, Galderisi U, Chambery A
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Impact Factor: 5.177
View Export to BibTeX Export to EndNote
Madonna S, Scarponi C, Doti N, Carbone T, Cavani A, Scognamiglio PL, Marasco D, Albanesi C
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Impact Factor: 4.518
View Export to BibTeX Export to EndNote
Iiritano S, Chiefari E, Ventura V, Arcidiacono B, Possidente K, Nocera A, Nevolo MT, Fedele M, Greco A, Greco M, Brunetti G, Fusco A, Foti D, Brunetti A
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Impact Factor: 4.746
View Export to BibTeX Export to EndNote
Sandomenico A, Russo A, Palmieri G, Bergamo P, Gogliettino M, Falcigno L, Ruvo M
* Small peptide inhibitors of acetyl-peptide hydrolase having an uncommon mechanism of inhibition and a stable bent conformation (521 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2012 Mar 8; 55(5): 2102-2111.
Impact Factor: 5.614
View Export to BibTeX Export to EndNote
Zannetti A, Iommelli F, Speranza A, Salvatore M, Del Vecchio S
* 3'-deoxy-3'-18F-fluorothymidine (FLT) PET/CT to guide therapy with epidermal growth factor receptor (EGFR) antagonists and Bcl-xL inhibitors in non-small cell lung cancer (615 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 2012 Mar 1; 53(3): 443-450.
Impact Factor: 5.774
View Export to BibTeX Export to EndNote
Zannetti A, Iommelli F, Speranza A, Salvatore M, Del Vecchio S
* 3'-deoxy-3'-18F-fluorothymidine PET/CT to guide therapy with epidermal growth factor receptor antagonists and Bcl-xL inhibitors in non-small cell lung cancer (527 views)
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Impact Factor: 5.774
View Export to BibTeX Export to EndNote
Vitagliano L, Fiume G, Scognamiglio PL, Doti N, Cannavo R, Puca A, Pedone C, Scala G, Quinto I, Marasco D
* Structural and functional insights into IkappaB-alpha/HIV-1 Tat interaction (603 views)
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Impact Factor: 3.022
View Export to BibTeX Export to EndNote
Canettieri G, Di Marcotullio L, Greco A, Coni S, Antonucci L, Infante P, Pietrosanti L, De Smaele E, Ferretti E, Miele E, Pelloni M, De Simone G, Pedone E, Gallinari P, Giorgi A, Steinkuhler C, Vitagliano L, Pedone C, Schinin ME, Screpanti I, Gulino A
* Histone deacetylase and Cullin3-REN(KCTD11) ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation (688 views)
Nature Cell Biol Nature Cell Biology (ISSN: 1476-4679, 1465-7392), 2010 Feb; 12(2): 132-142.
Impact Factor: 19.407
View Export to BibTeX Export to EndNote
Vitiello M, Finamore E, Falanga A, Raieta K, Cantisani M, Galdiero F, Pedone C, Galdiero M, Galdiero S
* Viral fusion peptides induce several signal transduction pathway activations that are essential for interleukin-10 and beta-interferon production (478 views)
Intervirology (ISSN: 1423-0100, 0300-5526), 2010; 53(6): 381-389.
Impact Factor: 1.756
View Export to BibTeX Export to EndNote
Marasco D, Stilo R, Sandomenico A, Monti SM, Tizzano B, De Capua A, Varricchio E, Liguoro D, Zotti T, Formisano S, Ruvo M, Vito P
* Generation And Functional Characterization Of A Bcl10-Inhibitory Peptide That Represses Nf-Kappa B Activation (602 views)
Biochem J (ISSN: 0264-6021, 1470-8728electronic, 0264-6021linking), 2009 Sep 15; 422(3): 553-561.
Impact Factor: 5.155
View Export to BibTeX Export to EndNote
Carriero MV, Longanesi-cattani I, Bifulco K, Maglio O, Lista L, Barbieri A, Votta G, Masucci MT, Arra C, Franco R, De Rosa M, Stoppelli MP, Pavone V
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Mol Cancer Ther (ISSN: 1535-7163, 1538-8514electronic, 1535-7163linking), 2009 Sep; 8(9): 2708-2717.
Impact Factor: 4.953
View Export to BibTeX Export to EndNote
Copani A, Hoozemans JJM, Caraci F, Calafiore M, Van Haastert ES, Veerhuis R, Rozemuller AJM, Aronica E, Sortino MA, Nicoletti F
* Dna Polymerase-Beta Is Expressed Early In Neurons Of Alzheimer'S Disease Brain And Is Loaded Into Dna Replication Forks In Neurons Challenged With Beta-Amyloid (504 views)
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Impact Factor: 2.117
View Export to BibTeX Export to EndNote
Cardone L, de Cristofaro T, Affaitati A, Garbi C, Ginsberg MD, Saviano M, Varrone S, Rubin CS, Gottesman ME, Avvedimento EV, Feliciello A
* A-kinase anchor protein 84/121 are targeted to mitochondria and mitotic spindles by overlapping amino-terminal motifs (725 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2002 Jul 12; 320(3): 663-675.
Impact Factor: 5.359
View Export to BibTeX Export to EndNote
Vitiello M, Finamore E, Falanga A, Raieta K, Cantisani M, Galdiero F, Pedone C, Galdiero M, Galdiero S
* Fusion in Coq (481 views)
Lecture Notes In Computer Science (ISSN: 0302-9743, 0302-974335404636319783540463634, 0302-974335402975459783540297543), 2001; 2178LNCS: 583-596.
Impact Factor: 0.415
View Export to BibTeX Export to EndNote
Carriero MV, Del Vecchio S, Franco P, Potena MI, Chiaradonna F, Botti G, Stoppelli MP, Salvatore M
Vitronectin binding to urokinase receptor in human breast cancer (449 views)
Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 1997 Sep; 3(8): 1299-1308.
Impact Factor: 3.419
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Carriero MV, Franco P, Del Vecchio S, Massa O, Botti G, D'Aiuto G, Stoppelli MP, Salvatore M
Tissue distribution of soluble and receptor-bound urokinase in human breast cancer using a panel of monoclonal antibodies (500 views)
Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 1994 Oct 15; 54(20): 5445-5454.
Impact Factor: 8.426
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FRITTITTA L, VIGNERI R, PAPA V, GOLDFINE I, GRASSO G, TRISCHITTA V
Structural and functional studies of insulin receptors in human breast cancer (446 views)
Breast Cancer Res Tr Kluwer Academic Publishers (ISSN: 0167-6806), 1993; 25(1): 73-82.
Impact Factor: 2.43
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26 Records (24 excluding Abstracts).
Total impact factor: 130.77 (124.958 excluding Abstracts).
Total 5 year impact factor: 138.089 (132.154 excluding Abstracts).
Total impact factor: 130.77 (124.958 excluding Abstracts).
Total 5 year impact factor: 138.089 (132.154 excluding Abstracts).
537 views. Last view on Friday 27 January 2023, 16:39:42
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