Increased troponin I predicts in-hospital occurrence of hemodynamic instability in patients with sub-massive or non-massive pulmonary embolism independent to clinical, echocardiographic and laboratory information
Increased troponin I predicts in-hospital occurrence of hemodynamic instability in patients with sub-massive or non-massive pulmonary embolism independent to clinical, echocardiographic and laboratory information(332 views) Gallotta G, Palmieri V, Piedimonte V, Rendina D, De Bonis S, Russo V, Celentano A, Di Minno M, Postiglione A, Di Minno G
Int J Cardiol (ISSN: 0167-5273, 1874-1754electronic, 0167-5273linking), 2008 Mar 14; 124(3): 351-357.
Department of Clinical and Experimental Medicine, Federico II University Medical School, Naples, Italy
Department of Emergency Medicine, A. O. Antonio Cardarelli, Naples, Italy
Division of Cardiology, CTO Hospital-ASL-NA1, Naples, Italy
Unit of Atherosclerosis and Thrombosis, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Foggia, Italy
References: Goldhaber, S.Z., Pulmonary embolism (2004) Lancet, 363, pp. 1295-130
Berman, A.R., Arnsten, J.H., Diagnosis and treatment of pulmonary embolism in the elderly (2003) Clin Geriatr Med, 19, pp. 157-175. , [viii]
Kniffin Jr., W.D., Baron, J.A., Barrett, J., Birkmeyer, J.D., Anderson Jr., F.A., The epidemiology of diagnosed pulmonary embolism and deep venous thrombosis in the elderly (1994) Arch Intern Med, 154, pp. 861-866
La Vecchia, L., Ottani, F., Favero, L., Increased cardiac troponin I on admission predicts in-hospital mortality in acute pulmonary embolism (2004) Heart, 90, pp. 633-637
Konstantinides, S., Geibel, A., Olschewski, M., Importance of cardiac troponins I and T in risk stratification of patients with acute pulmonary embolism (2002) Circulation, 106, pp. 1263-1268
Kucher, N., Goldhaber, S.Z., Cardiac biomarkers for risk stratification of patients with acute pulmonary embolism (2003) Circulation, 108, pp. 2191-2194
Kucher, N., Wallmann, D., Carone, A., Incremental prognostic value of troponin I and echocardiography in patients with acute pulmonary embolism (2003) Eur Heart J, 24, pp. 1651-1656
Giannitsis, E., Muller-Bardorff, M., Kurowski, V., Independent prognostic value of cardiac troponin T in patients with confirmed pulmonary embolism (2000) Circulation, 102, pp. 211-217
Alpert, J.S., Thygesen, K., Antman, E., Bassand, J.P., Myocardial infarction redefined-a consensus document of The Joint European Society of Cardiology/American College of Cardiology Committee for the redefinition of myocardial infarction (2000) J Am Coll Cardiol, 36, pp. 959-969
Braunwald, E., Antman, E.M., Beasley, J.W., ACC/AHA guidelines for the management of patients with unstable angina and non-ST-segment elevation myocardial infarction: executive summary and recommendations. A report of the American College of Cardiology/American Heart Association task force on practice guidelines (committee on the management of patients with unstable angina) (2000) Circulation, 102, pp. 1193-1209
Quiroz, R., Kucher, N., Schoepf, U.J., Right ventricular enlargement on chest computed tomography: prognostic role in acute pulmonary embolism (2004) Circulation, 109, pp. 2401-2404
Douketis, J.D., Crowther, M.A., Stanton, E.B., Ginsberg, J.S., Elevated cardiac troponin levels in patients with submassive pulmonary embolism (2002) Arch Intern Med, 162, pp. 79-81
Meneveau, N., Ming, L.P., Seronde, M.F., In-hospital and long-term outcome after sub-massive and massive pulmonary embolism submitted to thrombolytic therapy (2003) Eur Heart J, 24, pp. 1447-1454
Kucher, N., Walpoth, N., Wustmann, K., Noveanu, M., Gertsch, M., QR in V1-an ECG sign associated with right ventricular strain and adverse clinical outcome in pulmonary embolism (2003) Eur Heart J, 24, pp. 1113-1119
Wicki, J., Perneger, T.V., Junod, A.F., Bounameaux, H., Perrier, A., Assessing clinical probability of pulmonary embolism in the emergency ward: a simple score (2001) Arch Intern Med, 161, pp. 92-97
Rodger, M., Wells, P.S., Diagnosis of pulmonary embolism (2001) Thromb Res, 103, pp. V225-V238
Guidelines on diagnosis and management of acute pulmonary embolism, Task Force on Pulmonary Embolism, European Society of Cardiology (2000) Eur Heart J, 21, pp. 1301-1336
Harrigan, R.A., Jones, K., ABC of clinical electrocardiography. Conditions affecting the right side of the heart (2002) BMJ, 324, pp. 1201-1204
Kasper, W., Konstantinides, S., Geibel, A., Management strategies and determinants of outcome in acute major pulmonary embolism: results of a multicenter registry (1997) J Am Coll Cardiol, 30, pp. 1165-1171
Kircher, B.J., Himelman, R.B., Schiller, N.B., Noninvasive estimation of right atrial pressure from the inspiratory collapse of the inferior vena cava (1990) Am J Cardiol, 66, pp. 493-496
Pruszczyk, P., Bochowicz, A., Torbicki, A., Cardiac troponin T monitoring identifies high-risk group of normotensive patients with acute pulmonary embolism (2003) Chest, 123, pp. 1947-1952
Douketis, J.D., Leeuwenkamp, O., Grobara, P., The incidence and prognostic significance of elevated cardiac troponins in patients with submassive pulmonary embolism (2005) J Thromb Haemost, 3, pp. 508-513
Binder, L., Pieske, B., Olschewski, M., N-terminal pro-brain natriuretic peptide or troponin testing followed by echocardiography for risk stratification of acute pulmonary embolism (2005) Circulation, 112, pp. 1573-1579
Dalen, J.E., Thrombolysis in submassive pulmonary embolism? No (2003) J Thromb Haemost, 1, pp. 1130-1132
Thabut, G., Thabut, D., Myers, R.P., Thrombolytic therapy of pulmonary embolism: a meta-analysis (2002) J Am Coll Cardiol, 40, pp. 1660-1667
Goldhaber, S. Z., Pulmonary embolism (2004) Lancet, 363, pp. 1295-130
Berman, A. R., Arnsten, J. H., Diagnosis and treatment of pulmonary embolism in the elderly (2003) Clin Geriatr Med, 19, pp. 157-175. , [viii]
Kniffin Jr., W. D., Baron, J. A., Barrett, J., Birkmeyer, J. D., Anderson Jr., F. A., The epidemiology of diagnosed pulmonary embolism and deep venous thrombosis in the elderly (1994) Arch Intern Med, 154, pp. 861-866
Alpert, J. S., Thygesen, K., Antman, E., Bassand, J. P., Myocardial infarction redefined-a consensus document of The Joint European Society of Cardiology/American College of Cardiology Committee for the redefinition of myocardial infarction (2000) J Am Coll Cardiol, 36, pp. 959-969
Douketis, J. D., Crowther, M. A., Stanton, E. B., Ginsberg, J. S., Elevated cardiac troponin levels in patients with submassive pulmonary embolism (2002) Arch Intern Med, 162, pp. 79-81
Harrigan, R. A., Jones, K., ABC of clinical electrocardiography. Conditions affecting the right side of the heart (2002) BMJ, 324, pp. 1201-1204
Kircher, B. J., Himelman, R. B., Schiller, N. B., Noninvasive estimation of right atrial pressure from the inspiratory collapse of the inferior vena cava (1990) Am J Cardiol, 66, pp. 493-496
Douketis, J. D., Leeuwenkamp, O., Grobara, P., The incidence and prognostic significance of elevated cardiac troponins in patients with submassive pulmonary embolism (2005) J Thromb Haemost, 3, pp. 508-513
Dalen, J. E., Thrombolysis in submassive pulmonary embolism? No (2003) J Thromb Haemost, 1, pp. 1130-1132
Increased troponin I predicts in-hospital occurrence of hemodynamic instability in patients with sub-massive or non-massive pulmonary embolism independent to clinical, echocardiographic and laboratory information
Introduction: Whether in patients with acute central sub-massive or non-massive pulmonary embolism, mild troponin I increase (>0.03 mu g/L) predicts in-hospital occurrence of hemodynamic instability and death independent to prognostically relevant clinical, laboratory and echocardiographic information is not fully established. Methods and results: We evaluated consecutively patients admitted to the Emergency Room for pulmonary embolism; those in stable hemodynamics in whom central pulmonary embolism was confirmed by spiral-computed tomography were recruited. All participants underwent standardized study protocol, including clinical and diagnostic evaluation for assessment of severity of pulmonary embolism; therapy was established accordingly; troponin I was measured, but treatment protocol was not affected by knowledge of troponin I levels. Of 90 patients enrolled in the study, 33 (37%) developed hemodynamic instability during hospitalization (on average, 90 h :20 from admission). Troponin I was >0.03 mu g/L in 56% of the study population at admission, and predicted occurrence of hemodynamic instability during hospitalization (adjusted hazard ratio 9.8, 95% confidence interval 1.2-79.2), independent to age, gender, co-morbidity, systolic blood pressure, CK-MB, echocardiographic right ventricular dysfunction and other covariates. Twelve patients died during hospitalization (mean time to event 107 h +/- 24 from admission); troponin I >0.03 mu g/L predicted mortality in univariate analysis, but not after accounting for age, sex and clinical variables. Nevertheless, higher troponin as continuous variable correlated with higher likelihood of in-hospital death (adjusted likelihood ratio 2.2/mu g/L, 95% confidence interval 1.1-4.3) in multivariate analysis. In a further multivariate model, CK-MB predicted mortality independent of covariates and troponin I. Conclusions: In patients with acute central sub-massive or non-massive pulmonary embolism, even mild increase in troponin I >0.03 mu g/L may provide relevant short-term prognostic information independent to clinical, laboratory and echocardiographic data. (c) 2007 Elsevier Ireland Ltd. All rights reserved.
Increased troponin I predicts in-hospital occurrence of hemodynamic instability in patients with sub-massive or non-massive pulmonary embolism independent to clinical, echocardiographic and laboratory information
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Increased troponin I predicts in-hospital occurrence of hemodynamic instability in patients with sub-massive or non-massive pulmonary embolism independent to clinical, echocardiographic and laboratory information
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