Insights into cytochrome c-cardiolipin interaction. Role played by ionic strength (394 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2008 Jul 1; 47(26): 6928-6935.
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Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 3.379, 5-year impact factor: 3.402
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-46049115075&partnerID=40&md5=a828fb18bd354378401cf117481a9a45
Keywords: Alkali Metals, Antigens, Cell Death, Cell Membranes, Dissociation, Flow Interactions, Lipids, Liposomes, Phospholipids, Rate Constants, Sodium, Sodium Chloride, Theorem Proving, J) Conditions, Anion Concentrations, Apoptotic Processes, Cardiolipin (cl), Complex Stability, Cytochrome C (cyt C), Dissociation Processes, Early Stages, Kinetic Rates, Phospholipid Vesicles, Programmed Cell Death (pcd), Strength (igc: D5 D6), Structural Changes, Ionic Strength, Adenosine Triphosphate, Ferric Ion, Peroxidase, Animal Tissue, Apoptosis, Article, Binding Affinity, Binding Site, Enzyme Kinetics, Nonhuman, Oxidative Phosphorylation, Priority Journal, Protein Conformation, Protein Function, Protein Interaction, Cattle, Circular Dichroism, Cytochromes C, Horses, Osmolar Concentration, Protein Binding, Titrimetry, Kobus, Adenosine Triphosphate Metabolism, Cardiolipins Chemistry Metabolism, Cytochromes C Chemistry Metabolism, Peroxidase Metabolism,
Affiliations:
*** IBB - CNR ***
Dipartimento di Medicina Sperimentale e Scienze Biochimiche, Università di Roma Tor Vergata, 00133 Roma, Italy
Dipartimento di Scienze Chimiche, Università di Catania, 95100 Catania, Italy
Dipartimento di Chimica, Università di Roma La Sapienza, 00185 Roma, Italy
References:
Moore, G.R., Pettigrew, G.W., (1990) Cytochromes c. Evolutionary, structural and physicochemical aspects, , Springer-Verlag, Heidelberg, German
Pettigrew, G.W., Moore, G.R., (1987) Cytochromes c. Biological aspects, , Springer-Verlag, Heidelberg, Germany
Bayir, H., Fadeel, B., Palladino, M.J., Witasp, E., Kurnikov, I.V., Tyurina, Y.Y., Tyurin, V.A., Kagan, V.E., Apoptotic interactions of cytochrome c: Redox flirting with anionic phospholipids within and outside of mitochondria (2006) Biochim. Biophys. Acta, 1757, pp. 648-659
Berezhna, S., Wohlrab, H., Champion, P.M., Resonance Raman investigations of cytochrome c conformational change upon interactions with the membranes of intact and Ca2+ exposed mitochondria (2003) Biochemistry, 42, pp. 6149-6158
Liu, X., Kim, C.N., Yang, J., Jemmerson, R., Wang, X., Induction of apoptotic program in cell-free extracts: Requirement for dATP and cytochrome c (1996) Cell, 86, pp. 147-157
Kluk, R.M., Bossy-Wetzel, E., Green, D.R., Newmeyer, D.D., The release of cytochrome c from mitochondria: A primary site for Bcl-2 regulation of apoptosis (1997) Science, 275, pp. 1132-1136
Li, P., Nijhawan, D., Budihardjo, I., Srinivasula, S.M., Ahmad, M., Alnemri, E.S., Wang, X., Cytochrome c and d-ATP dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade (1997) Cell, 91, pp. 479-489
Zou, H., Li, Y., Liu, X., Wang, X., An Apaf-1 cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9 (1999) J. Biol. Chem, 274, pp. 11549-11556
Purring-Koch, C., McLendon, G., Cytochrome c binding to Apaf-1: The effects of dATP and ionic strength (2000) Proc. Natl. Acad. Sci. U.S.A, 97, pp. 11928-11931
Jemmerson, R., Liu, J., Hausauer, D., Lam, K.P., Mondino, A., Nelson, R.D., A conformational change in cytochrome c of apoptotic and necrotic cells is detected by monoclonal antibody binding and mimicked by association of the native antigen with synthetic phospholipid vesicles (1999) Biochemistry, 38, pp. 3599-3609
Quinn, P.J., Dawson, M.C., Interaction of cytochrome c and (14C)carboxy-methylated cytochrome c with monolayers of phosphatidylcholine, phosphatidic acid and cardiolipin (1969) Biochem. J, 115, pp. 65-75
Rytömaa, M., Mustonen, P., Kinnunen, K.J., Reversible, non-ionic, and pH-dependent association of cytochrome c with cardiolipin-phosphatidylcholine liposomes (1992) J. Biol. Chem, 267, pp. 22243-22248
Ott, M., Zhivotovsky, B., Orrenius, S., Role of cardiolipin in cytochrome c release from mitochondria (2007) Cell Death Differ, 14, pp. 1243-1247
Vladimirov, Y.A., Proskurnina, E.V., Izmailov, D.Y., Novikov, A.A., Brusnichkin, A.V., Osipov, A.N., Kagan, V.E., Cardiolipin activates cytochrome c peroxidase activity since it facilitates H2O 2 access to heme (2006) Biochemistry (Moscow, Russ. Fed.), 71, pp. 998-1005
Kagan, V.E., Tyurin, V.A., Jiang, J., Tyurina, Y.Y., Ritov, V.B., Amoscato, A.A., Osipov, A.N., Borisenko, G.G., Cytochrome c acts as a cardiolipin oxygenase required for release of proapoptotic factors (2005) Nat. Chem. Biol, 1, pp. 223-232
Belikova, N.A., Vladimirov, Y.A., Osipov, A.N., Kapralov, A.A., Tyurin, V.A., Potapovich, M.V., Basova, L.V., Kagan, V.E., Peroxidase activity and structural transitions of cytochrome c bound to cardiolipin-containing membranes (2006) Biochemistry, 45, pp. 4998-5009
Rytömaa, M., Kinnunen, K.J., Evidence for two distinct acidic phospholipids-binding sites in cytochrome c (1994) J. Biol. Chem, 269, pp. 1770-1774
Tuominen, F.K., Wallace, C.J., Kinnunen, P.K.J., Phospholipid-cytochrome c interaction: Evidence for the extended lipid anchorage (2002) J. Biol. Chem, 277, pp. 8822-8826
Kawai, C., Prado, F.M., Nunes, G.L.C., Di Mascio, P., Carmona-Ribeiro, A.M., Nantes, I.L., pH-dependent interaction of cytochrome c with mitochondrial mimetic membranes. The role of an array of positively charged amino acids (2005) J. Biol. Chem, 280, pp. 34709-34717
Subuddhi, U., Mishra, A.K., Micellization of bile salts in aqueous medium: A fluorescence study (2007) Colloids Surf., B, 57, pp. 102-107
Blauer, G., Sreerama, N., Woody, R., Optical activity of hemoproteins in the Soret region. Circular dichroism of the undecapeptide of cytochrome c in aqueous solution (1993) Biochemistry, 32, pp. 6674-6679
Pielak, G.J., Oikawa, K., Mauk, A.G., Smith, M., Kay, C.M., Elimination of the negative Soret Cotton effect of eukariotic cytochromes c by replacement of an invariant phenylalanine residue by site-directed mutagenesis (1986) J. Am. Chem. Soc, 108, pp. 2724-2727
Santucci, R., Ascoli, F., The Soret circular dichroism spectrum as a probe for the heme Fe(III)-Met(80) axial bond in horse cytochrome c (1997) J. Inorg. Biochem, 68, pp. 211-214
Sinibaldi, F., Piro, M.C., Howes, B.D., Smulevich, G., Ascoli, F., Santucci, R., Rupture of the H-bond linking two omega-loops induces the molten globule state at neutral pH in cytochrome c (2003) Biochemistry, 42, pp. 7604-7610
Touminen, E.K.J., Zhu, K., Wallace, C.J.A., Clark-Lewis, I., Craig, D.B., Rytömaa, M., Kinnunen, P.K.J., ATP induces a conformational change in lipid-bound cytochrome c (2001) J. Biol. Chem, 276, pp. 19356-19361
Green, D.R., Reed, J.C., Mitochondria and apoptosis (1998) Science, 281, pp. 1309-1312
Kalanxhi, E., Wallace, C.J.A., Cytochrome c impaled: Investigation of the extended lipid anchorage of a soluble protein to mitochondrial membrane models (2007) Biochem. J, 407, pp. 179-187
De Sanctis, G., Ciaccio, C., Fasciglione, G.F., Fiorucci, L., Gioia, M., Marini, S., Sinibaldi, F., Coletta, M., Effect of axial coordination on kinetics of assembly and folding of the two halves of horse heart cytochrome c (2004) J. Biol. Chem, 279, pp. 52860-52868
Sinibaldi, F., Howes, B.D., Smulevich, G., Ciaccio, C., Coletta, M., Santucci, R., Anion concentration modulates conformation and stability of the molten globule of cytochrome c (2003) J. Biol. Inorg. Chem, 8, pp. 663-670
Craig, D.B., Wallace, C.J.A., ATP binding to cytochrome c diminishes electron flow in the mitochondrial respiratory pathway (1993) Protein Sci, 2, pp. 966-976
Sinibaldi, F., Mei, G., Polticelli, M., Piro, M.C., Howes, B.D., Smulevich, G., Santucci, R., Fiorucci, L., ATP specifically drives refolding of nonnative conformations of cytochrome c (2005) Protein Sci, 14, pp. 1049-1058
Diederix, R.E., Ubbink, M., Canters, G.W., Peroxidase Activity as a Tool for Studying the folding of c-type cytochromes (2002) Biochemistry, 41, pp. 13067-13077
Moore, G. R., Pettigrew, G. W., (1990) Cytochromes c. Evolutionary, structural and physicochemical aspects, , Springer-Verlag, Heidelberg, German
Pettigrew, G. W., Moore, G. R., (1987) Cytochromes c. Biological aspects, , Springer-Verlag, Heidelberg, Germany
Liu, X., Kim, C. N., Yang, J., Jemmerson, R., Wang, X., Induction of apoptotic program in cell-free extracts: Requirement for dATP and cytochrome c (1996) Cell, 86, pp. 147-157
Kluk, R. M., Bossy-Wetzel, E., Green, D. R., Newmeyer, D. D., The release of cytochrome c from mitochondria: A primary site for Bcl-2 regulation of apoptosis (1997) Science, 275, pp. 1132-1136
Quinn, P. J., Dawson, M. C., Interaction of cytochrome c and (14C) carboxy-methylated cytochrome c with monolayers of phosphatidylcholine, phosphatidic acid and cardiolipin (1969) Biochem. J, 115, pp. 65-75
Ryt maa, M., Mustonen, P., Kinnunen, K. J., Reversible, non-ionic, and pH-dependent association of cytochrome c with cardiolipin-phosphatidylcholine liposomes (1992) J. Biol. Chem, 267, pp. 22243-22248
Vladimirov, Y. A., Proskurnina, E. V., Izmailov, D. Y., Novikov, A. A., Brusnichkin, A. V., Osipov, A. N., Kagan, V. E., Cardiolipin activates cytochrome c peroxidase activity since it facilitates H2O 2 access to heme (2006) Biochemistry (Moscow, Russ. Fed.), 71, pp. 998-1005
Kagan, V. E., Tyurin, V. A., Jiang, J., Tyurina, Y. Y., Ritov, V. B., Amoscato, A. A., Osipov, A. N., Borisenko, G. G., Cytochrome c acts as a cardiolipin oxygenase required for release of proapoptotic factors (2005) Nat. Chem. Biol, 1, pp. 223-232
Belikova, N. A., Vladimirov, Y. A., Osipov, A. N., Kapralov, A. A., Tyurin, V. A., Potapovich, M. V., Basova, L. V., Kagan, V. E., Peroxidase activity and structural transitions of cytochrome c bound to cardiolipin-containing membranes (2006) Biochemistry, 45, pp. 4998-5009
Ryt maa, M., Kinnunen, K. J., Evidence for two distinct acidic phospholipids-binding sites in cytochrome c (1994) J. Biol. Chem, 269, pp. 1770-1774
Tuominen, F. K., Wallace, C. J., Kinnunen, P. K. J., Phospholipid-cytochrome c interaction: Evidence for the extended lipid anchorage (2002) J. Biol. Chem, 277, pp. 8822-8826
Pielak, G. J., Oikawa, K., Mauk, A. G., Smith, M., Kay, C. M., Elimination of the negative Soret Cotton effect of eukariotic cytochromes c by replacement of an invariant phenylalanine residue by site-directed mutagenesis (1986) J. Am. Chem. Soc, 108, pp. 2724-2727
Touminen, E. K. J., Zhu, K., Wallace, C. J. A., Clark-Lewis, I., Craig, D. B., Ryt maa, M., Kinnunen, P. K. J., ATP induces a conformational change in lipid-bound cytochrome c (2001) J. Biol. Chem, 276, pp. 19356-19361
Green, D. R., Reed, J. C., Mitochondria and apoptosis (1998) Science, 281, pp. 1309-1312
Craig, D. B., Wallace, C. J. A., ATP binding to cytochrome c diminishes electron flow in the mitochondrial respiratory pathway (1993) Protein Sci, 2, pp. 966-976
Diederix, R. E., Ubbink, M., Canters, G. W., Peroxidase Activity as a Tool for Studying the folding of c-type cytochromes (2002) Biochemistry, 41, pp. 13067-13077
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2008 Jul 1; 47(26): 6928-6935.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 3.379, 5-year impact factor: 3.402
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-46049115075&partnerID=40&md5=a828fb18bd354378401cf117481a9a45
Keywords: Alkali Metals, Antigens, Cell Death, Cell Membranes, Dissociation, Flow Interactions, Lipids, Liposomes, Phospholipids, Rate Constants, Sodium, Sodium Chloride, Theorem Proving, J) Conditions, Anion Concentrations, Apoptotic Processes, Cardiolipin (cl), Complex Stability, Cytochrome C (cyt C), Dissociation Processes, Early Stages, Kinetic Rates, Phospholipid Vesicles, Programmed Cell Death (pcd), Strength (igc: D5 D6), Structural Changes, Ionic Strength, Adenosine Triphosphate, Ferric Ion, Peroxidase, Animal Tissue, Apoptosis, Article, Binding Affinity, Binding Site, Enzyme Kinetics, Nonhuman, Oxidative Phosphorylation, Priority Journal, Protein Conformation, Protein Function, Protein Interaction, Cattle, Circular Dichroism, Cytochromes C, Horses, Osmolar Concentration, Protein Binding, Titrimetry, Kobus, Adenosine Triphosphate Metabolism, Cardiolipins Chemistry Metabolism, Cytochromes C Chemistry Metabolism, Peroxidase Metabolism,
Affiliations:
*** IBB - CNR ***
Dipartimento di Medicina Sperimentale e Scienze Biochimiche, Università di Roma Tor Vergata, 00133 Roma, Italy
Dipartimento di Scienze Chimiche, Università di Catania, 95100 Catania, Italy
Dipartimento di Chimica, Università di Roma La Sapienza, 00185 Roma, Italy
References:
Moore, G.R., Pettigrew, G.W., (1990) Cytochromes c. Evolutionary, structural and physicochemical aspects, , Springer-Verlag, Heidelberg, German
Pettigrew, G.W., Moore, G.R., (1987) Cytochromes c. Biological aspects, , Springer-Verlag, Heidelberg, Germany
Bayir, H., Fadeel, B., Palladino, M.J., Witasp, E., Kurnikov, I.V., Tyurina, Y.Y., Tyurin, V.A., Kagan, V.E., Apoptotic interactions of cytochrome c: Redox flirting with anionic phospholipids within and outside of mitochondria (2006) Biochim. Biophys. Acta, 1757, pp. 648-659
Berezhna, S., Wohlrab, H., Champion, P.M., Resonance Raman investigations of cytochrome c conformational change upon interactions with the membranes of intact and Ca2+ exposed mitochondria (2003) Biochemistry, 42, pp. 6149-6158
Liu, X., Kim, C.N., Yang, J., Jemmerson, R., Wang, X., Induction of apoptotic program in cell-free extracts: Requirement for dATP and cytochrome c (1996) Cell, 86, pp. 147-157
Kluk, R.M., Bossy-Wetzel, E., Green, D.R., Newmeyer, D.D., The release of cytochrome c from mitochondria: A primary site for Bcl-2 regulation of apoptosis (1997) Science, 275, pp. 1132-1136
Li, P., Nijhawan, D., Budihardjo, I., Srinivasula, S.M., Ahmad, M., Alnemri, E.S., Wang, X., Cytochrome c and d-ATP dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade (1997) Cell, 91, pp. 479-489
Zou, H., Li, Y., Liu, X., Wang, X., An Apaf-1 cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9 (1999) J. Biol. Chem, 274, pp. 11549-11556
Purring-Koch, C., McLendon, G., Cytochrome c binding to Apaf-1: The effects of dATP and ionic strength (2000) Proc. Natl. Acad. Sci. U.S.A, 97, pp. 11928-11931
Jemmerson, R., Liu, J., Hausauer, D., Lam, K.P., Mondino, A., Nelson, R.D., A conformational change in cytochrome c of apoptotic and necrotic cells is detected by monoclonal antibody binding and mimicked by association of the native antigen with synthetic phospholipid vesicles (1999) Biochemistry, 38, pp. 3599-3609
Quinn, P.J., Dawson, M.C., Interaction of cytochrome c and (14C)carboxy-methylated cytochrome c with monolayers of phosphatidylcholine, phosphatidic acid and cardiolipin (1969) Biochem. J, 115, pp. 65-75
Rytömaa, M., Mustonen, P., Kinnunen, K.J., Reversible, non-ionic, and pH-dependent association of cytochrome c with cardiolipin-phosphatidylcholine liposomes (1992) J. Biol. Chem, 267, pp. 22243-22248
Ott, M., Zhivotovsky, B., Orrenius, S., Role of cardiolipin in cytochrome c release from mitochondria (2007) Cell Death Differ, 14, pp. 1243-1247
Vladimirov, Y.A., Proskurnina, E.V., Izmailov, D.Y., Novikov, A.A., Brusnichkin, A.V., Osipov, A.N., Kagan, V.E., Cardiolipin activates cytochrome c peroxidase activity since it facilitates H2O 2 access to heme (2006) Biochemistry (Moscow, Russ. Fed.), 71, pp. 998-1005
Kagan, V.E., Tyurin, V.A., Jiang, J., Tyurina, Y.Y., Ritov, V.B., Amoscato, A.A., Osipov, A.N., Borisenko, G.G., Cytochrome c acts as a cardiolipin oxygenase required for release of proapoptotic factors (2005) Nat. Chem. Biol, 1, pp. 223-232
Belikova, N.A., Vladimirov, Y.A., Osipov, A.N., Kapralov, A.A., Tyurin, V.A., Potapovich, M.V., Basova, L.V., Kagan, V.E., Peroxidase activity and structural transitions of cytochrome c bound to cardiolipin-containing membranes (2006) Biochemistry, 45, pp. 4998-5009
Rytömaa, M., Kinnunen, K.J., Evidence for two distinct acidic phospholipids-binding sites in cytochrome c (1994) J. Biol. Chem, 269, pp. 1770-1774
Tuominen, F.K., Wallace, C.J., Kinnunen, P.K.J., Phospholipid-cytochrome c interaction: Evidence for the extended lipid anchorage (2002) J. Biol. Chem, 277, pp. 8822-8826
Kawai, C., Prado, F.M., Nunes, G.L.C., Di Mascio, P., Carmona-Ribeiro, A.M., Nantes, I.L., pH-dependent interaction of cytochrome c with mitochondrial mimetic membranes. The role of an array of positively charged amino acids (2005) J. Biol. Chem, 280, pp. 34709-34717
Subuddhi, U., Mishra, A.K., Micellization of bile salts in aqueous medium: A fluorescence study (2007) Colloids Surf., B, 57, pp. 102-107
Blauer, G., Sreerama, N., Woody, R., Optical activity of hemoproteins in the Soret region. Circular dichroism of the undecapeptide of cytochrome c in aqueous solution (1993) Biochemistry, 32, pp. 6674-6679
Pielak, G.J., Oikawa, K., Mauk, A.G., Smith, M., Kay, C.M., Elimination of the negative Soret Cotton effect of eukariotic cytochromes c by replacement of an invariant phenylalanine residue by site-directed mutagenesis (1986) J. Am. Chem. Soc, 108, pp. 2724-2727
Santucci, R., Ascoli, F., The Soret circular dichroism spectrum as a probe for the heme Fe(III)-Met(80) axial bond in horse cytochrome c (1997) J. Inorg. Biochem, 68, pp. 211-214
Sinibaldi, F., Piro, M.C., Howes, B.D., Smulevich, G., Ascoli, F., Santucci, R., Rupture of the H-bond linking two omega-loops induces the molten globule state at neutral pH in cytochrome c (2003) Biochemistry, 42, pp. 7604-7610
Touminen, E.K.J., Zhu, K., Wallace, C.J.A., Clark-Lewis, I., Craig, D.B., Rytömaa, M., Kinnunen, P.K.J., ATP induces a conformational change in lipid-bound cytochrome c (2001) J. Biol. Chem, 276, pp. 19356-19361
Green, D.R., Reed, J.C., Mitochondria and apoptosis (1998) Science, 281, pp. 1309-1312
Kalanxhi, E., Wallace, C.J.A., Cytochrome c impaled: Investigation of the extended lipid anchorage of a soluble protein to mitochondrial membrane models (2007) Biochem. J, 407, pp. 179-187
De Sanctis, G., Ciaccio, C., Fasciglione, G.F., Fiorucci, L., Gioia, M., Marini, S., Sinibaldi, F., Coletta, M., Effect of axial coordination on kinetics of assembly and folding of the two halves of horse heart cytochrome c (2004) J. Biol. Chem, 279, pp. 52860-52868
Sinibaldi, F., Howes, B.D., Smulevich, G., Ciaccio, C., Coletta, M., Santucci, R., Anion concentration modulates conformation and stability of the molten globule of cytochrome c (2003) J. Biol. Inorg. Chem, 8, pp. 663-670
Craig, D.B., Wallace, C.J.A., ATP binding to cytochrome c diminishes electron flow in the mitochondrial respiratory pathway (1993) Protein Sci, 2, pp. 966-976
Sinibaldi, F., Mei, G., Polticelli, M., Piro, M.C., Howes, B.D., Smulevich, G., Santucci, R., Fiorucci, L., ATP specifically drives refolding of nonnative conformations of cytochrome c (2005) Protein Sci, 14, pp. 1049-1058
Diederix, R.E., Ubbink, M., Canters, G.W., Peroxidase Activity as a Tool for Studying the folding of c-type cytochromes (2002) Biochemistry, 41, pp. 13067-13077
Moore, G. R., Pettigrew, G. W., (1990) Cytochromes c. Evolutionary, structural and physicochemical aspects, , Springer-Verlag, Heidelberg, German
Pettigrew, G. W., Moore, G. R., (1987) Cytochromes c. Biological aspects, , Springer-Verlag, Heidelberg, Germany
Liu, X., Kim, C. N., Yang, J., Jemmerson, R., Wang, X., Induction of apoptotic program in cell-free extracts: Requirement for dATP and cytochrome c (1996) Cell, 86, pp. 147-157
Kluk, R. M., Bossy-Wetzel, E., Green, D. R., Newmeyer, D. D., The release of cytochrome c from mitochondria: A primary site for Bcl-2 regulation of apoptosis (1997) Science, 275, pp. 1132-1136
Quinn, P. J., Dawson, M. C., Interaction of cytochrome c and (14C) carboxy-methylated cytochrome c with monolayers of phosphatidylcholine, phosphatidic acid and cardiolipin (1969) Biochem. J, 115, pp. 65-75
Ryt maa, M., Mustonen, P., Kinnunen, K. J., Reversible, non-ionic, and pH-dependent association of cytochrome c with cardiolipin-phosphatidylcholine liposomes (1992) J. Biol. Chem, 267, pp. 22243-22248
Vladimirov, Y. A., Proskurnina, E. V., Izmailov, D. Y., Novikov, A. A., Brusnichkin, A. V., Osipov, A. N., Kagan, V. E., Cardiolipin activates cytochrome c peroxidase activity since it facilitates H2O 2 access to heme (2006) Biochemistry (Moscow, Russ. Fed.), 71, pp. 998-1005
Kagan, V. E., Tyurin, V. A., Jiang, J., Tyurina, Y. Y., Ritov, V. B., Amoscato, A. A., Osipov, A. N., Borisenko, G. G., Cytochrome c acts as a cardiolipin oxygenase required for release of proapoptotic factors (2005) Nat. Chem. Biol, 1, pp. 223-232
Belikova, N. A., Vladimirov, Y. A., Osipov, A. N., Kapralov, A. A., Tyurin, V. A., Potapovich, M. V., Basova, L. V., Kagan, V. E., Peroxidase activity and structural transitions of cytochrome c bound to cardiolipin-containing membranes (2006) Biochemistry, 45, pp. 4998-5009
Ryt maa, M., Kinnunen, K. J., Evidence for two distinct acidic phospholipids-binding sites in cytochrome c (1994) J. Biol. Chem, 269, pp. 1770-1774
Tuominen, F. K., Wallace, C. J., Kinnunen, P. K. J., Phospholipid-cytochrome c interaction: Evidence for the extended lipid anchorage (2002) J. Biol. Chem, 277, pp. 8822-8826
Pielak, G. J., Oikawa, K., Mauk, A. G., Smith, M., Kay, C. M., Elimination of the negative Soret Cotton effect of eukariotic cytochromes c by replacement of an invariant phenylalanine residue by site-directed mutagenesis (1986) J. Am. Chem. Soc, 108, pp. 2724-2727
Touminen, E. K. J., Zhu, K., Wallace, C. J. A., Clark-Lewis, I., Craig, D. B., Ryt maa, M., Kinnunen, P. K. J., ATP induces a conformational change in lipid-bound cytochrome c (2001) J. Biol. Chem, 276, pp. 19356-19361
Green, D. R., Reed, J. C., Mitochondria and apoptosis (1998) Science, 281, pp. 1309-1312
Craig, D. B., Wallace, C. J. A., ATP binding to cytochrome c diminishes electron flow in the mitochondrial respiratory pathway (1993) Protein Sci, 2, pp. 966-976
Diederix, R. E., Ubbink, M., Canters, G. W., Peroxidase Activity as a Tool for Studying the folding of c-type cytochromes (2002) Biochemistry, 41, pp. 13067-13077
Insights into cytochrome c-cardiolipin interaction. Role played by ionic strength
The finding that cytochrome c (cyt c) plays a role in programmed cell death after its release from the mitochondrion has recently renewed interest in this protein. The structural changes in cytochrome c observed at early stages of the apoptotic process have been related to changes occurring in the protein when it forms a complex with phospholipid vesicles. Among the lipids constituting the membrane, cardiolipin is the one thought to bind to cyt c. In this paper, we have investigated the influence exerted by ionic strength on cytochrome c-cardiolipin interaction and found that formation of the cytochrome c-cardiolipin complex occurs via two distinct transitions, implying a high-affinity site and a low-affinity site. Ionic strength significantly influences complex stability; sodium chloride dissociates the complex through two distinct transitions, the second of which occurs at a very high anion concentration. ATP also dissociates the complex, but under the conditions that were investigated, its action is limited to the high-affinity site. The dissociation process is characterized by a very slow kinetic rate constant (kobs = 4.2 × 10-3 s-1) and requires several minutes to be completed. We ascribe it to the high activation barrier met by the protein when restoring the native Fe(III)-M80 axial bond. The peroxidase activity shown by cardiolipin-bound cytochrome c is indicative of a less packed protein tertiary conformation in the complex. In line with earlier reports, these data highlight the manifold functions of cytochrome c besides the well-known role it plays in oxidative phosphorylation, shedding more light on the properties of the cytochrome c-cardiolipin complex, involved in the progression of early stages of apoptosis. © 2008 American Chemical Society.
The finding that cytochrome c (cyt c) plays a role in programmed cell death after its release from the mitochondrion has recently renewed interest in this protein. The structural changes in cytochrome c observed at early stages of the apoptotic process have been related to changes occurring in the protein when it forms a complex with phospholipid vesicles. Among the lipids constituting the membrane, cardiolipin is the one thought to bind to cyt c. In this paper, we have investigated the influence exerted by ionic strength on cytochrome c-cardiolipin interaction and found that formation of the cytochrome c-cardiolipin complex occurs via two distinct transitions, implying a high-affinity site and a low-affinity site. Ionic strength significantly influences complex stability; sodium chloride dissociates the complex through two distinct transitions, the second of which occurs at a very high anion concentration. ATP also dissociates the complex, but under the conditions that were investigated, its action is limited to the high-affinity site. The dissociation process is characterized by a very slow kinetic rate constant (kobs = 4.2 × 10-3 s-1) and requires several minutes to be completed. We ascribe it to the high activation barrier met by the protein when restoring the native Fe(III)-M80 axial bond. The peroxidase activity shown by cardiolipin-bound cytochrome c is indicative of a less packed protein tertiary conformation in the complex. In line with earlier reports, these data highlight the manifold functions of cytochrome c besides the well-known role it plays in oxidative phosphorylation, shedding more light on the properties of the cytochrome c-cardiolipin complex, involved in the progression of early stages of apoptosis. © 2008 American Chemical Society.
Insights into cytochrome c-cardiolipin interaction. Role played by ionic strength
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Insights into cytochrome c-cardiolipin interaction. Role played by ionic strength
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Satriano C, Messina GM, Marino C, Aiello I, Conte E, La Mendola D, Distefano DA, D'Alessandro F, Pappalardo G, Impellizzeri G
* Surface immobilization of fibronectin-derived PHSRN peptide on functionalized polymer films - Effects on fibroblast spreading (534 views)
J Colloid Interface Sci (ISSN: 1095-7103electronic, 0021-9797linking), 2010 Jan 15; 341(2): 232-239.
Impact Factor: 3.068
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Giuffrida ML, Caraci F, Pignataro B, Cataldo S, De Bona P, Bruno V, Molinaro G, Pappalardo G, Messina A, Palmigiano A, Garozzo D, Nicoletti F, Rizzarelli E, Copani A
* Beta-Amyloid Monomers Are Neuroprotective (659 views)
J Neurosci (ISSN: 1529-2401, 0270-6474), 2009 Sep 26; 29(34): 10582-10587.
Impact Factor: 3.669
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Marasco D, Stilo R, Sandomenico A, Monti SM, Tizzano B, De Capua A, Varricchio E, Liguoro D, Zotti T, Formisano S, Ruvo M, Vito P
* Generation And Functional Characterization Of A Bcl10-Inhibitory Peptide That Represses Nf-Kappa B Activation (490 views)
Biochem J (ISSN: 0264-6021, 1470-8728electronic, 0264-6021linking), 2009 Sep 15; 422(3): 553-561.
Impact Factor: 5.155
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Galdiero S, Falanga A, Vitiello M, Raiola L, Fattorusso R, Browne H, Pedone C, Isernia C, Galdiero M
* Analysis of a membrane interacting region of herpes simplex virus type 1 glycoprotein (581 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2008 Oct 31; 283(44): 29993-30009.
Impact Factor: 5.52
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Hilvo M, Baranauskiene L, Salzano AM, Scaloni A, Matulis D, Innocenti A, Scozzafava A, Monti SM, Di Fiore A, De Simone G, Lindfors M, Janis J, Valjakka J, Pastorekova S, Pastorek J, Kulomaa MS, Nordlund HR, Supuran CT, Parkkila S
* Biochemical characterization of CA IX, one of the most active carbonic anhydrase isozymes (459 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2008 Oct 10; 283(41): 27799-27809.
Impact Factor: 5.52
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Merlino A, Varriale S, Coscia MR, Mazzarella L, Oreste U
* Structure and dimerization of the teleost transmembrane immunoglobulin region (377 views)
Journal Of Molecular Graphics & Modelling (ISSN: 1093-3263), 2008 Oct; 27(3): 401-407.
Impact Factor: 2.347
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Bonomo RP, Pappalardo G, Rizzarelli E, Tabbì G, Vagliasindi LI
* Studies of nitric oxide interaction with mono- and dinuclear copper(II) complexes of prion protein bis-octarepeat fragments (309 views)
Dalton T (ISSN: 1477-9226, 1477-9234, 1477-9234electronic), 2008 Sep 7; (29): 3805-3816.
Impact Factor: 3.58
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Viparelli F, Cassese A, Doti N, Paturzo F, Marasco D, Dathan NA, Monti SM, Basile G, Ungaro P, Sabatella M, Miele C, Teperino R, Consiglio E, Pedone C, Beguinot F, Formisano P, Ruvo M
* Targeting of PED/PEA-15 molecular interaction with phospholipase D1 enhances insulin sensitivity in skeletal muscle cells (437 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2008 Sep 1; 283(31): 21769-21778.
Impact Factor: 5.52
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Zeni O, Palumbo R, Bernini R, Zeni L, Sarti M, Scarfi MR
* Cytotoxicity investigation on cultured human blood cells treated with single-wall carbon nanotubes (321 views)
Sensors (ISSN: 1424-3210, 1424-8220, 1424-8220electronic), 2008 Jan; 8(1): 488-499.
Impact Factor: 1.87
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Zannetti A, Fonti R, Iommelli F, Papaccioli A, Sommella J, Tortora G, Bianco R, Salvatore M, Del Vecchio S
* SPECT imaging of endoplasmic reticulum-mediated tumor response to gefitinib and erlotinib in lung cancer (424 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2007 Oct; 34: 277-309.
Impact Factor: 4.101
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Nicoletti VG, Santoro AM, Grasso G, Vagliasindi LI, Giuffrida ML, Cuppari C, Purrello VS, Stella AMG, Rizzarelli E
* Carnosine interaction with nitric oxide and astroglial cell protection (648 views)
Journal Of Neuroscience Research (ISSN: 0360-4012), 2007 Sep 1; 85(10): 2239-2245.
Impact Factor: 3.268
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Ntziachristos V, Cuénod CA, Fournier L, Balvay D, Pradel C, Siauve N, Clement O, Jouannot E, Lucidarme O, Vecchio SD, Salvatore M, Law B, Tung C-H, Jain RK, Fukumura D, Munn LL, Brown EB, Schellenberger E, Montet X, Weissleder R, Clerck ND, Postnov A
* Tumor Imaging (350 views)
Textbook Of In Vivo Imaging In Vertebrates (ISSN: 9780-4700), 2007 Jul 16; 1: 277-309.
Impact Factor: 1.148
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Papa S, Monti SM, Vitale RM, Bubici C, Jayawardena S, Alvarez K, De Smaele E, Dathan N, Pedone C, Ruvo M, Franzoso G
* Insights Into The Structural Basis Of The Gadd45beta-Mediated Inactivation Of The Jnk Kinase, Mkk7/Jnkk2 (489 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2007 Jun 29; 282(26): 19029-19041.
Impact Factor: 5.581
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Copani A, Caraci F, Hoozemans J, Calafiore M, Sortino M, Nicoletti F
* The nature of the cell cycle in neurons: Focus on a "non-canonical" pathway of DNA replication causally related to death (481 views)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2007 Apr; 1772(4): 409-412.
Impact Factor: 3.078
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Ronga L, Langella E, Palladino P, Marasco D, Tizzano B, Saviano M, Pedone C, Improta R, Ruvo M
* Does Tetracycline Bind Helix 2 Of Prion? An Integrated Spectroscopical And Computational Study Of The Interaction Between The Antibiotic And Alpha Helix 2 Human Prion Protein Fragments (512 views)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2007 Feb 15; 66(3): 707-715.
Impact Factor: 3.354
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Pappalardo G, Milardi D, Magrì A, Attanasio F, Impellizzeri G, La Rosa C, Grasso D, Rizzarelli E
* Environmental factors differently affect human and rat IAPP: Conformational preferences and membrane interactions of IAPP17-29 peptide derivatives (607 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2007; 13(36): 10204-10215.
Impact Factor: 5.33
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Aloj L, Aurilio M, Rinaldi V, D'Ambrosio L, Tesauro D, Peitl PK, Maina T, Mansi R, Von Guggenberg E, Joosten L, Sosabowski JK, Breeman WA, De Blois E, Koelewijn S, Melis M, Waser B, Beetschen K, Reubi JC, De Jong M
* The EEE project (449 views)
Proc Int Cosm Ray Conf Icrc Universidad Nacional Autonoma De Mexico, 2007; 5(HEPART2): 977-980.
Impact Factor: 0
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Barone V, Newton MD, Improta R
* Dissociative electron transfer in donor - Peptide - Acceptor systems: Results for kinetic parameters from a density functional/polarizable continuum model (247 views)
J Phys Chem B (ISSN: 1520-6106, 1520-5207, 1520-5207electronic), 2006 Jun 29; 110(25): 12632-12639.
Impact Factor: 4.115
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Galdiero S, Falanga A, Vitiello M, Browne H, Pedone C, Galdiero M
* Fusogenic domains in herpes simplex virus type 1 glycoprotein (590 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2005 Sep 5; 280(31): 28632-28643.
Impact Factor: 5.854
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Marrazzo A, Caraci F, Salinaro ET, Su TP, Copani A, Ronsisvalle G
* Neuroprotective effects of sigma-1 receptor agonists against beta-amyloid-induced toxicity (584 views)
Neuroreport (ISSN: 0959-4965), 2005 Sep 1; 16(11): 1223-1226.
Impact Factor: 1.995
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Bucci E, Vitagliano L, Barone R, Sorrentino S, D'Alessio G, Graziano G
* On the thermal stability of the two dimeric forms of ribonuclease (417 views)
Biophys Chem (ISSN: 0301-4622, 0301-4622linking), 2005 Jul 1; 116(2): 89-95.
Impact Factor: 1.925
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Picone D, Di Fiore A, Ercole C, Franzese M, Sica F, Tomaselli S, Mazzarella L
* The role of the hinge loop in domain swapping - The special case of bovine seminal ribonuclease (367 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2005 Apr 8; 280(14): 13771-13778.
Impact Factor: 5.854
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De Luca S, Sanseverino M, Zocchi I, Pedone C, Morelli G, Ragone R
* Receptor fragment approach to the binding between CCK8 peptide and cholecystokinin receptors: A fluorescence study on type B receptor fragment CCKB-R (352-379) (359 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2005 Mar; 77(4): 205-211.
Impact Factor: 2.545
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Barone V, Formaggio F, Improta R, Polo F, Maran F
* Electron transfer to and conformational preferences of Aib oligo-peptides (385 views)
Proc Electrochem Soc, 2004; 10: 29-32.
Impact Factor: 0
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De Luca S, Ragone R, Bracco C, Digilio G, Aloj L, Tesauro D, Saviano M, Pedone C, Morelli G
* A cyclic CCK8 analogue selective for the cholecystokinin type A receptor: design, synthesis, NMR structure and binding measurements (472 views)
Chembiochem (ISSN: 1439-7633, 1439-4227, 1439-7633electronic), 2003 Nov 7; 4(11): 1176-1187.
Impact Factor: 3.992
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Portella G, Pacelli R, Libertini S, Cella L, Vecchio G, Salvatore M, Fusco A
* ONYX-015 Enhances Radiation-Induced Death of Human Anaplastic Thyroid Carcinoma Cells (467 views)
J Clin Endocrinol Metab Journal Of Clinical Endocrinology And Metabolism (ISSN: 0021-972x), 2003 Oct 1; 88(10): 5027-5032.
Impact Factor: 5.873
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Russo M, Palumbo R, Mupo A, Tosto M, Iacomino G, Scognamiglio A, Tedesco I, Galano G, Russo GL
* Flavonoid quercetin sensitizes a CD95-resistant cell line to apoptosis by activating protein kinase Cα (437 views)
Oncogene (ISSN: 0950-9232, 1476-5594), 2003; 22(21): 3330-3342.
Impact Factor: 6.495
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Aloj L, Panico M, Caracó C, Zannetti A, Del Vecchio S, Di Nuzzo C, Arra C, Morelli G, Tesauro D, De Luca S, Pedone C, Salvatore M
* Radiolabeling approaches for cholecystokinin B receptor imaging (496 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2002; 66(6): 370-380.
Impact Factor: 2.372
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Saracino GAA, Tedeschi A, D'Errico G, Improta R, Franco L, Ruzzi M, Corvaia C, Barone V
* Solvent polarity and pH effects on the magnetic properties of ionizable nitroxide radicals: A combined computational and experimental study of 2, 2, 5, 5-tetramethyl-3-carboxypyrrolidine and 2, 2, 6, 6-tetramethyl-4-carboxypiperidine nitroxides (280 views)
J Phys Chem A (ISSN: 1089-5639, 1520-5215electronic), 2002; 106(44): 10700-10706.
Impact Factor: 2.765
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De Falco S, Ruvoletto MG, Verdoliva A, Ruvo M, Raucci A, Marino M, Senatore S, Cassani G, Alberti A, Pontisso P, Fassina G
* Cloning and Expression of a Novel Hepatitis B Virus-binding Protein from HepG2 Cells (622 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2001 Sep 28; 276(39): 36613-36623.
Impact Factor: 7.258
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Ragone R, De Luca S, Tesauro D, Pedone C, Morelli G
Fluorescence studies on the binding between 1-47 fragment of cholecystokinin receptor CCKA-R(1-47) and nonsulfated cholecystokinin octapeptide CCK8 (419 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2000; 56(1): 47-53.
Impact Factor: 2.405
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Gallo P, Rossi F, Saviano M, Pedone C, Colonna G, Ragone R
Specific interaction between bovine cyclophilin A and synthetic analogues of cyclolinopeptide (393 views)
Journal Of Biochemistry (ISSN: 0021-924x), 1998 Nov; 124(5): 880-885.
Impact Factor: 2.189
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Wink DA, Cook JA, Pacelli R, DeGraff W, Gamson J, Liebmann J, Krishna MC, Mitchell JB
The effect of various nitric oxide-donor agents on hydrogen peroxide-mediated toxicity: A direct correlation between nitric oxide formation and protection (685 views)
Arch Bioch Bioph (ISSN: 0003-9861, 0003-9861linking), 1996 Jul 15; 331(2): 241-248.
Impact Factor: 2.649
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Levchenko A, Mehta B, Spengler BA, Narkar A, Fonti R, Biedler JL, Tsuruo T, Larson SM
Measurement of P-glycoprotein expression in multidrug-resistant human neuroblastoma cell lines using self-competitive binding assay (283 views)
Anal Biochem (ISSN: 0003-2697, 1096-0309electronic, 0003-2697linking), 1996 May 1; 236(2): 338-343.
Impact Factor: 2.017
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Arena G, Bindoni M, Cardile V, Maccarrone G, Riello MC, Rizzarelli E, Sciuto S
Cytotoxic and cytostatic activity of copper(II) complexes. Importance of the speciation for the correct interpretation of the in vitro biological results (477 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 1993 Apr 1; 50(1): 31-45.
Impact Factor: 1.342
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* Design, Optimization, and Structural Characterization of an Apoptosis-Inducing Factor Peptide Targeting Human Cyclophilin A to Inhibit Apoptosis Inducing Factor-Mediated Cell Death (11 views)
J Med Chem (ISSN: 0022-2623linking), 2021 Aug 12; 64 (15 ): 11445-11459.
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Chelko SP, Keceli G, Carpi A, Doti N, Agrimi J, Asimaki A, Beti CB, Miyamoto M, Amat-codina N, Bedja D, Wei AC, Murray B, Tichnell C, Kwon C, Calkins H, James CA, O , #rourke B, Halushka MK, Melloni E, Saffitz JE, Judge DP, Ruvo M, Kitsis RN, Andersen P, Di Lisa F, Paolocci N
* Exercise triggers CAPN1-mediated AIF truncation, inducing myocyte cell death in arrhythmogenic cardiomyopathy (165 views)
Sci Transl Med (ISSN: 1946-6234linking), 2021 Feb 17; 13(581): N/D-N/D.
Impact Factor: 17.956
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Longo F, Perri F, Caponigro F, Della Vittoria Scarpati G, Guida A, Pavone E, Aversa C, Muto P, Giuliano M, Ionna F, Solla R
* Boosting the Immune Response with the Combination of Electrochemotherapy and Immunotherapy: A New Weapon for Squamous Cell Carcinoma of the Head and Neck? (55 views)
Cancers (ISSN: 2072-6694linking), 2020 Sep 28; 12(10): N/D-N/D.
Impact Factor: 6.126
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Miceli M, Cutignano A, Conte M, Ummarino R, Romanelli A, Ruvo M, Leone M, Mercurio FA, Doti N, Manzo E, Romano G, Altucci L, Ianora A
* Monoacylglycerides from the Diatom Skeletonema marinoi Induce Selective Cell Death in Cancer Cells (158 views)
Mar Drugs (ISSN: 1660-3397linking), 2019 Nov 1; 17 (11 ): N/D-N/D.
Impact Factor: 3.345
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Conte C, Moret F, Esposito D, Dal Poggetto G, Avitabile C, Ungaro F, Romanelli A, Laurienzo P, Reddi E, Quaglia F
* Biodegradable nanoparticles exposing a short anti-FLT1 peptide as antiangiogenic platform to complement docetaxel anticancer activity (214 views)
Mater Sci Eng C Mater Biol Appl (ISSN: 0928-4931linking), 2019 Sep; 102: 876-886.
Impact Factor: 5.08
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Carafa V, Nebbioso A, Cuomo F, Rotili D, Cobellis G, Bontempo P, Baldi A, Spugnini EP, Citro G, Chambery A, Russo R, Ruvo M, Ciana P, Maravigna L, Shaik J, Radaelli E, De Antonellis P, Tarantino D, Pirolli A, Ragno R, Zollo M, Stunnenberg HG, Mai A, Altucci L
* RIP1-HAT1-SIRT Complex Identification and Targeting in Treatment and Prevention of Cancer (244 views)
Clin Cancer Res (ISSN: 1078-0432print, 1078-0432linking), 2018 Jun 15; 24(12): 2886-2900.
Impact Factor: 6.488
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Petraglia F, Singh AA, Carafa V, Nebbioso A, Conte M, Scisciola L, Valente S, Baldi A, Mandoli A, Petrizzi VB, Ingenito C, De Falco S, Cicatiello V, Apicella I, Janssen-megens EM, Kim B, Yi G, Logie C, Heath S, Ruvo M, Wierenga ATJ, Flicek P, Yaspo ML, Della Valle V, Bernard O, Tomassi S, Novellino E, Feoli A, Sbardella G, Gut I, Vellenga E, Stunnenberg HG, Mai A, Martens JHA, Altucci L
* Combined HAT/EZH2 modulation leads to cancer-selective cell death (284 views)
Oncotarget (ISSN: 1949-2553electronic, 1949-2553linking), 2018 May 22; 9(39): 25630-25646.
Impact Factor: 5.008
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Farina B, Sturlese M, Mascanzoni F, Caporale A, Monti A, Sorbo GD, Fattorusso R, Ruvo M, Doti N
* Binding mode of AIF(370–394) peptide to CypA: insights from NMR, label-free and molecular docking studies (1068 views)
Biochem J (ISSN: 0264-6021, 1470-8728electronic, 0264-6021linking), 2018; 475(14): 2377-2393.
Impact Factor: 4.897
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Cutrin JC, Alberti D, Bernacchioni C, Ciambellotti S, Turano P, Luchinat C, Crich SG, Aime S
* Cancer cell death induced by ferritins and the peculiar role of their labile iron pool (210 views)
Oncotarget, 2018; N/D: N/D-N/D.
Impact Factor: 5.168
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Russo L, Farina B, Del Gatto A, Comegna D, Di Gaetano S, Capasso D, Liguoro D, Malgieri G, Saviano M, Fattorusso R, Zaccaro L
* Deciphering RGDechi peptide‐α5β1 integrin interaction mode in isolated cell membranes (265 views)
Peptide Science, 2018; N/D: N/D-N/D.
Impact Factor: 2.081
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Oliveri V, Lanza V, Milardi D, Viale M, Maric I, Sgarlata C, Vecchio G
* Amino- and chloro-8-hydroxyquinolines and their copper complexes as proteasome inhibitors and antiproliferative agents (462 views)
Metallomics (ISSN: 1756-5901, 1756-591x), 2017 Oct 18; 9(10): 1439-1446.
Impact Factor: 4.069
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Doti N, Ruvo M
* Relevance and therapeutic potential of CypA targeting to block apoptosis inducing factor-mediated neuronal cell death (365 views)
Neural Regen Res (ISSN: 1673-5374), 2017 Sep; 12(9): 1428-1429.
Impact Factor: 2.234
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Gaglione R, Pirone L, Farina B, Fusco S, Smaldone G, Aulitto M, Dell'Olmo E, Roscetto E, Del Gatto A, Fattorusso R, Notomista E, Zaccaro L, Arciello A, Pedone E, Contursi P
* Insights into the anticancer properties of the first antimicrobial peptide from Archaea (409 views)
Bba-Gen Subjects (ISSN: 0005-2728, 0006-3002print, 0304-4165linking), 2017 Jun 15; 1861(9): 2155-2164.
Impact Factor: 4.28
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Martínez-fernández L, Granucci G, Pollum M, Crespo-hernández CE, Persico M, Corral I
* Decoding the Molecular Basis for the Population Mechanism of the Triplet Phototoxic Precursors in UVA Light-Activated Pyrimidine Anticancer Drugs (363 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2017; 23(11): 2619-2627.
Impact Factor: 5.16
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Avitabile C, D'Andrea LD, Saviano M, Olivieri M, Cimmino A, Romanelli A
* Binding studies of antimicrobial peptides to Escherichia coli cells (389 views)
Biochem Bioph Res Co (ISSN: 0006-291x), 2016 Sep 09; 478(1): 149-153.
Impact Factor: 2.466
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Farina B, De Paola I, Russo L, Capasso D, Liguoro A, Gatto AD, Saviano M, Pedone PV, Di Gaetano S, Malgieri G, Zaccaro L, Fattorusso R
* A Combined NMR and Computational Approach to Determine the RGDechi-hCit-alphav beta3 Integrin Recognition Mode in Isolated Cell Membranes (628 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2016 Jan 11; 22(2): 681-693.
Impact Factor: 5.317
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Guardiani C, Scorciapino MA, Amodeo GF, Grdadolnik J, Pappalardo G, De Pinto V, Ceccarelli M, Casu M
* The N-Terminal Peptides of the Three Human Isoforms of the Mitochondrial Voltage-Dependent Anion Channel Have Different Helical Propensities (462 views)
Biochemistry (ISSN: 0006-2960, 1520-4995), 2015 Sep 15; 54(36): 5646-5656.
Impact Factor: 2.876
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Zhang Y, de La Harpe K, Beckstead AA, Improta R, Kohler B
* UV-Induced Proton Transfer between DNA Strands (388 views) (PDF 242 views)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 0002-7863print), 2015 Jun 10; 137(22): 7059-7062.
Impact Factor: 13.038
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Calce E, Monfregola L, Saviano M, De Luca S
* HER2-mediated anticancer drug delivery: strategies to prepare targeting ligands highly specific for the receptor (571 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2015 May 20; 22(21): 2525-2538.
Impact Factor: 3.455
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GrassoG, Satriano C, Milardi D
* A neglected modulator of insulin-degrading enzyme activity and conformation: The pH (406 views)
Biophys Chem (ISSN: 0301-4622, 0301-4622linking), 2015; 203-204: 33-40.
Impact Factor: 2.363
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Vitiello G, Falanga A, Petruk AA, Merlino A, Fragneto G, Paduano L, Galdiero S, D'Errico G
* Fusion of raft-like lipid bilayers operated by a membranotropic domain of the HSV-type I glycoprotein gH occurs through a cholesterol-dependent mechanism (381 views)
Soft Matter (ISSN: 1744-683x), 2015; 11(15): 3003-3016.
Impact Factor: 3.798
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Merlo S, Basile L, Giuffrida ML, Sortino MA, Guccione S, Copani A
* Identification of 5-Methoxyflavone as a Novel DNA Polymerase-Beta Inhibitor and Neuroprotective Agent against Beta-Amyloid Toxicity (323 views)
J Nat Prod (ISSN: 0163-3864), 2015; 78(11): 2704-2711.
Impact Factor: 3.662
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Hangen E, Féraud O, Lachkar S, Mou H, Doti N, Fimia GM, Lam N-V, Zhu C, Godin I, Muller K, Chatzi A, Nuebel E, Ciccosanti F, Flamant S, Bénit P, Perfettini J-L, Sauvat A, Bennaceur-Griscelli A, Ser-Le Roux K, Gonin P, Tokatlidis K, Rustin P, Piacentini M, Ruvo M, Blomgren K, Kroemer G, Modjtahedi N
* Interaction between AIF and CHCHD4 Regulates Respiratory Chain Biogenesis (521 views)
Mol Cell (ISSN: 1097-2765, 1097-4164), 2015; 58(6): 1001-1014.
Impact Factor: 13.958
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Mercurio FA, Di Natale C, Pirone L, Scognamiglio PL, Marasco D, Pedone EM, Saviano M, Leone M
* Peptide Fragments of Odin-Sam1: Conformational Analysis and Interaction Studies with EphA2-Sam (464 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-4227linking), 2015; 16(11): 1629-1636.
Impact Factor: 2.85
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Picone D, Donnarumma F, Ferraro G, Russo Krauss I, Fagagnini A, Gotte G, Merlino A
* Platinated oligomers of bovine pancreatic ribonuclease: Structure and stability (414 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2015; 146: 37-43.
Impact Factor: 3.205
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Oppermann S, Schrader FC, Elsasser K, Dolga AM, Kraus AL, Doti N, Wegscheid-Gerlach C, Schlitzer M, Culmsee C
* Novel N-Phenyl-Substituted Thiazolidinediones Protect Neural Cells against Glutamate- and tBid-Induced Toxicity (578 views)
J Pharmacol Exp Ther (ISSN: 0022-3565, 1521-0103), 2014 Sep; 350(2): 273-289.
Impact Factor: 3.972
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Balasco N, Pirone L, Smaldone G, Di Gaetano S, Esposito L, Pedone E, Vitagliano L
* Molecular recognition of Cullin3 by KCTDs: Insights from experimental and computational investigations (366 views)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2014 Jul; 1844(7): 1289-1298.
Impact Factor: 4.882
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Messori L, Scaletti F, Massai L, Cinellu MA, Russo Krauss I, Di Martino G, Vergara A, Paduano L, Merlino A
* Interactions of gold-based drugs with proteins: crystal structure of the adduct formed between ribonuclease A and a cytotoxic gold(III) compound (339 views)
Metallomics (ISSN: 1756-5901, 1756-591x), 2014; 6(2): 233-236.
Impact Factor: 3.585
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Milardi D, Sciacca MF, Randazzo L, Raudino A, La Rosa C
* The role of calcium, lipid membranes and islet amyloid polypeptide in the onset of type 2 diabetes: Innocent bystanders or partners in a crime? (541 views)
Front Endocrinol (ISSN: 1664-2392, 1664-2392linking, 1664-2392print), 2014; 5(DEC): 216-216.
Impact Factor: 3.675
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Bellia F, GrassoG
* The role of copper(II) and zinc(II) in the degradation of human and murine IAPP by insulin-degrading enzyme (520 views)
J Mass Spectrom (ISSN: 1076-5174, 1096-9888), 2014; 49(4): 274-279.
Impact Factor: 2.379
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Passaro C, Abagnale A, Libertini S, Volpe M, Botta G, Cella L, Pacelli R, Halldèn G, Gillespie D, Portella G
* Ionizing radiation enhances dl922-947-mediated cell death of anaplastic thyroid carcinoma cells (444 views)
Endocr Relat Cancerendocrine Related Cancer (ISSN: 1351-0088), 2013 Sep 19; 20(5): 633-647.
Impact Factor: 4.907
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Nande R, Greco A, Gossman MS, Lopez JP, Claudio L, Salvatore M, Brunetti A, Denvir J, Howard CM, Claudio PP
* Microbubble-assisted p53, RB, and p130 gene transfer in combination with radiation therapy in prostate cancer (457 views)
Current Gene Therapy (ISSN: 1875-5631, 1566-5232), 2013 Jun 1; 13(3): 163-174.
Impact Factor: 4.906
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Lombardo B, Rocco T, Esposito MT, Cantilena B, Gargiulo S, Greco A, Montanaro D, Brunetti A, Pastore L
* Thymidine Kinase-Mediated Shut Down of Bone Morphogenetic Protein-4 Expression Allows Regulated Bone Production (350 views)
Current Gene Therapy (ISSN: 1566-5232, 1875-5631), 2013 Jun 1; 13(3): 202-210.
Impact Factor: 4.906
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Perrino C, Schiattarella GG, Sannino A, Pironti G, Petretta MP, Cannavo A, Gargiulo G, Ilardi F, Magliulo F, Franzone A, Carotenuto G, Serino F, Altobelli GG, Cimini V, Cuocolo A, Lombardi A, Goglia F, Indolfi C, Trimarco B, Esposito G
* Genetic deletion of uncoupling protein 3 exaggerates apoptotic cell death in the ischemic heart leading to heart failure (428 views)
J Am Heart Assoc Journal Of The American Heart Association (ISSN: 2047-9980), 2013 May 20; 2(3): e000086-e000086.
Impact Factor: 2.882
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Dolga AM, Netter MF, Perocchi F, Doti N, Meissner L, Tobaben S, Grohm J, Zischka H, Plesnila N, Decher N, Culmsee C
* Mitochondrial Small Conductance SK2 Channels Prevent Glutamate-induced Oxytosis and Mitochondrial Dysfunction (535 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2013 Apr 12; 288(15): 10792-10804.
Impact Factor: 4.6
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Diana D, Di Stasi R, De Rosa L, Isernia C, D'Andrea LD, Fattorusso R
* Structural investigation of the VEGF receptor interaction with a helical antagonist peptide (399 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2013 Apr; 19(4): 214-219.
Impact Factor: 1.862
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Calce E, Monfregola L, Sandomenico A, Saviano M, De Luca S
* Fluorescence study for selecting specific ligands toward HER2 receptor: An example of receptor fragment approach (438 views)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 1768-3254electronic), 2013 Mar; 61: 116-121.
Impact Factor: 3.432
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Merlino A, Fuchs MR, Pica A, Balsamo A, Dworkowski FSN, Pompidor G, Mazzarella L, Vergara A
* Selective X-ray-induced NO photodissociation in haemoglobin crystals: evidence from a Raman-assisted crystallographic study (339 views)
Acta Crystallogr D Biol Crystallogr (ISSN: 0907-4449, 0907-4449linking), 2013 Jan; 69: 137-140.
Impact Factor: 7.232
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Vitiello G, Fragneto G, Petruk AA, Falanga A, Galdiero S, D'Ursi A, Merlino A, D'Errico G
* Cholesterol modulates the fusogenic activity of a membranotropic domain of the FIV glycoprotein gp36 (410 views)
Soft Matter (ISSN: 1744-683x), 2013; 9(28): 6442-6456.
Impact Factor: 4.151
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Tedesco I, Russo M, Bilotto S, Spagnuolo C, Scognamiglio A, Palumbo R, Nappo A, Iacomino G, Moio L, Russo GL
* Dealcoholated red wine induces autophagic and apoptotic cell death in an osteosarcoma cell line (509 views)
Food Chem Toxicol (ISSN: 0278-6915), 2013; 60: 377-384.
Impact Factor: 2.61
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Merlino A, Fuchs MR, Pica A, Balsamo A, Dworkowski FSN, Pompidor G, Mazzarella L, Vergara A
* Selective X-Ray Induced No-Photodissociation In Hemoglobin Crystals: Evidence From A Raman Assisted-Crystallographic Study (302 views)
Acta Cryst D 69, 2013; 1: 137-140.
Impact Factor: 0
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Calabrese V, Cornelius C, Dinkova-Kostova AT, Iavicoli I, Di Paola R, Koverech A, Cuzzocrea S, Rizzarelli E, Calabrese EJ
* Cellular stress responses, hormetic phytochemicals and vitagenes in aging and longevity (3606 views)
Bba-Gen Subjects (ISSN: 0006-3002, 0925-4439, 1570-9639), 2012 May; 1822(5): 753-783.
Impact Factor: 3.733
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Galdiero S, Russo L, Falanga A, Cantisani M, Vitiello M, Fattorusso R, Malgieri G, Galdiero M, Isernia C
* Structure and Orientation of the gH625-644 Membrane Interacting Region of Herpes Simplex Virus Type 1 in a Membrane Mimetic System (368 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2012 Apr 10; 51(14): 3121-3128.
Impact Factor: 3.377
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Merlino A, Vitiello G, Grimaldi M, Sica F, Busi E, Basosi R, D’Ursi A, Fragneto G, Paduano L, D’Errico G
* Destabilization of Lipid Membranes by a Peptide Derived from Glycoprotein gp36 of Feline Immunodeficiency Virus: A Combined Molecular Dynamics/Experimental Study (470 views)
J Phys Chem B (ISSN: 1520-6106, 1520-5207, 1520-5207electronic), 2012 Jan 12; 116(1): 401-412.
Impact Factor: 3.607
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Folgiero V, Di Carlo SE, Bossi G, Spugnini E, Di Benedetto A, Bon G, Milella M, Fabi A, Accardo A, Morelli G, Mottolese M, Falcioni R
* Inhibition of p85, the non-catalytic subunit of phosphatidylinositol 3-kinase, exerts potent antitumor activity in human breast cancer cells (517 views)
Cell Death & (ISSN: 2041-4889, 2041-4889electronic), 2012; 3(12): N/D-N/D.
Impact Factor: 6.044
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Diana D, Basile A, De Rosa L, Di Stasi R, Auriemma S, Arra C, Pedone C, Turco MC, Fattorusso R, D'Andrea LD
* Beta-Hairpin Peptide That Targets Vascular Endothelial Growth Factor (vegf) Receptors: Design, Nmr Characterization, And Biological Activity (620 views)
Jbc Papers (ISSN: 1083-351x, 0021-9258, 0021-9258linking), 2011 Dec 2; 286(48): 41680-41691.
Impact Factor: 4.773
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Falanga A, Vitiello MT, Cantisani M, Tarallo R, Guarnieri D, Mignogna E, Netti P, Pedone C, Galdiero M, Galdiero S
* A peptide derived from herpes simplex virus type 1 glycoprotein H: membrane translocation and applications to the delivery of quantum dots (1040 views)
Nanomedicine (ISSN: 1549-9642, 1549-9634, 1549-9642electronic), 2011 Dec; 7(6): 925-934.
Impact Factor: 6.692
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Malgieri G, Zaccaro L, Leone M, Bucci E, Esposito S, Baglivo I, Del Gatto A, Russo L, Scandurra R, Pedone PV, Fattorusso R, Isernia C
* Zinc to Cadmium Replacement in the A. thaliana SUPERMAN Cys(2)His(2) Zinc Finger Induces Structural Rearrangements of Typical DNA Base Determinant Positions (445 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2011 Nov; 95(11): 801-810.
Impact Factor: 2.87
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Dettin M, Ghezzo F, Conconi MT, Urbani L, D'Auria G, Falcigno L, Guidolin D, Nico B, Ribatti D, Di Bello C, Parnigotto PP
* In vitro and in vivo pro-angiogenic effects of thymosin-β4-derived peptides (480 views)
Cell Immunol (ISSN: 0008-8749), 2011; 271(2): 299-307.
Impact Factor: 1.974
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Di Natale G, Pappalardo G, Milardi D, Sciacca MF, Attanasio F, La Mendola D, Rizzarelli E
* Membrane interactions and conformational preferences of human and avian prion N-terminal tandem repeats: The role of copper(II) ions, pH, and membrane mimicking environments (494 views)
J Phys Chem B (ISSN: 1520-6106, 1520-5207, 1520-5207electronic), 2010 Nov 4; 114(43): 13830-13838.
Impact Factor: 3.603
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Perrino C, Feliciello A, Schiattarella GG, Esposito G, Guerriero R, Zaccaro L, Del Gatto A, Saviano M, Garbi C, Carangi R, Di Lorenzo E, Donato G, Indolfi C, Avvedimento VE, Chiariello M
* AKAP121 downregulation impairs protective cAMP signals, promotes mitochondrial dysfunction, and increases oxidative stress (433 views)
Cardiovascular Research (ISSN: 0008-6363), 2010 Oct; 88(1): 101-110.
Impact Factor: 6.051
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Galdiero S, Falanga A, Vitiello M, Raiola L, Russo L, Pedone C, Isernia C, Galdiero M
* The presence of a single N-terminal histidine residue enhances the fusogenic properties of a Membranotropic peptide derived from herpes simplex virus type 1 glycoprotein (471 views)
Jbc Papers (ISSN: 1083-351x, 0021-9258, 0021-9258linking), 2010 May 28; 285(22): 17123-17136.
Impact Factor: 5.328
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Merlino A, Vergara A, Sica F, Aschi M, Amadei A, Di Nola A, Mazzarella L
* Free-Energy Profile for CO Binding to Separated Chains of Human and Trematomus newnesi Hemoglobin: Insights from Molecular Dynamics Simulations and Perturbed Matrix Method (301 views)
J Phys Chem B (ISSN: 1520-6106, 1520-5207, 1520-5207electronic), 2010 May 27; 114(20): 7002-7008.
Impact Factor: 3.603
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Alberobello AT, D'Esposito V, Marasco D, Doti N, Ruvo M, Bianco R, Tortora G, Esposito I, Fiory F, Miele C, Beguinot F, Formisano P
* Selective Disruption of Insulin-like Growth Factor-1 (IGF-1) Signaling via Phosphoinositide-dependent Kinase-1 Prevents the Protective Effect of IGF-1 on Human Cancer Cell Death (578 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2010 Feb 26; 285(9): 6563-6572.
Impact Factor: 5.328
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Satriano C, Messina GM, Marino C, Aiello I, Conte E, La Mendola D, Distefano DA, D'Alessandro F, Pappalardo G, Impellizzeri G
* Surface immobilization of fibronectin-derived PHSRN peptide on functionalized polymer films - Effects on fibroblast spreading (534 views)
J Colloid Interface Sci (ISSN: 1095-7103electronic, 0021-9797linking), 2010 Jan 15; 341(2): 232-239.
Impact Factor: 3.068
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Giuffrida ML, Caraci F, Pignataro B, Cataldo S, De Bona P, Bruno V, Molinaro G, Pappalardo G, Messina A, Palmigiano A, Garozzo D, Nicoletti F, Rizzarelli E, Copani A
* Beta-Amyloid Monomers Are Neuroprotective (659 views)
J Neurosci (ISSN: 1529-2401, 0270-6474), 2009 Sep 26; 29(34): 10582-10587.
Impact Factor: 3.669
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Marasco D, Stilo R, Sandomenico A, Monti SM, Tizzano B, De Capua A, Varricchio E, Liguoro D, Zotti T, Formisano S, Ruvo M, Vito P
* Generation And Functional Characterization Of A Bcl10-Inhibitory Peptide That Represses Nf-Kappa B Activation (490 views)
Biochem J (ISSN: 0264-6021, 1470-8728electronic, 0264-6021linking), 2009 Sep 15; 422(3): 553-561.
Impact Factor: 5.155
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Galdiero S, Falanga A, Vitiello M, Raiola L, Fattorusso R, Browne H, Pedone C, Isernia C, Galdiero M
* Analysis of a membrane interacting region of herpes simplex virus type 1 glycoprotein (581 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2008 Oct 31; 283(44): 29993-30009.
Impact Factor: 5.52
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Hilvo M, Baranauskiene L, Salzano AM, Scaloni A, Matulis D, Innocenti A, Scozzafava A, Monti SM, Di Fiore A, De Simone G, Lindfors M, Janis J, Valjakka J, Pastorekova S, Pastorek J, Kulomaa MS, Nordlund HR, Supuran CT, Parkkila S
* Biochemical characterization of CA IX, one of the most active carbonic anhydrase isozymes (459 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2008 Oct 10; 283(41): 27799-27809.
Impact Factor: 5.52
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Merlino A, Varriale S, Coscia MR, Mazzarella L, Oreste U
* Structure and dimerization of the teleost transmembrane immunoglobulin region (377 views)
Journal Of Molecular Graphics & Modelling (ISSN: 1093-3263), 2008 Oct; 27(3): 401-407.
Impact Factor: 2.347
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Bonomo RP, Pappalardo G, Rizzarelli E, Tabbì G, Vagliasindi LI
* Studies of nitric oxide interaction with mono- and dinuclear copper(II) complexes of prion protein bis-octarepeat fragments (309 views)
Dalton T (ISSN: 1477-9226, 1477-9234, 1477-9234electronic), 2008 Sep 7; (29): 3805-3816.
Impact Factor: 3.58
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Viparelli F, Cassese A, Doti N, Paturzo F, Marasco D, Dathan NA, Monti SM, Basile G, Ungaro P, Sabatella M, Miele C, Teperino R, Consiglio E, Pedone C, Beguinot F, Formisano P, Ruvo M
* Targeting of PED/PEA-15 molecular interaction with phospholipase D1 enhances insulin sensitivity in skeletal muscle cells (437 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2008 Sep 1; 283(31): 21769-21778.
Impact Factor: 5.52
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Zeni O, Palumbo R, Bernini R, Zeni L, Sarti M, Scarfi MR
* Cytotoxicity investigation on cultured human blood cells treated with single-wall carbon nanotubes (321 views)
Sensors (ISSN: 1424-3210, 1424-8220, 1424-8220electronic), 2008 Jan; 8(1): 488-499.
Impact Factor: 1.87
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Zannetti A, Fonti R, Iommelli F, Papaccioli A, Sommella J, Tortora G, Bianco R, Salvatore M, Del Vecchio S
* SPECT imaging of endoplasmic reticulum-mediated tumor response to gefitinib and erlotinib in lung cancer (424 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2007 Oct; 34: 277-309.
Impact Factor: 4.101
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Nicoletti VG, Santoro AM, Grasso G, Vagliasindi LI, Giuffrida ML, Cuppari C, Purrello VS, Stella AMG, Rizzarelli E
* Carnosine interaction with nitric oxide and astroglial cell protection (648 views)
Journal Of Neuroscience Research (ISSN: 0360-4012), 2007 Sep 1; 85(10): 2239-2245.
Impact Factor: 3.268
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Ntziachristos V, Cuénod CA, Fournier L, Balvay D, Pradel C, Siauve N, Clement O, Jouannot E, Lucidarme O, Vecchio SD, Salvatore M, Law B, Tung C-H, Jain RK, Fukumura D, Munn LL, Brown EB, Schellenberger E, Montet X, Weissleder R, Clerck ND, Postnov A
* Tumor Imaging (350 views)
Textbook Of In Vivo Imaging In Vertebrates (ISSN: 9780-4700), 2007 Jul 16; 1: 277-309.
Impact Factor: 1.148
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Papa S, Monti SM, Vitale RM, Bubici C, Jayawardena S, Alvarez K, De Smaele E, Dathan N, Pedone C, Ruvo M, Franzoso G
* Insights Into The Structural Basis Of The Gadd45beta-Mediated Inactivation Of The Jnk Kinase, Mkk7/Jnkk2 (489 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2007 Jun 29; 282(26): 19029-19041.
Impact Factor: 5.581
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Copani A, Caraci F, Hoozemans J, Calafiore M, Sortino M, Nicoletti F
* The nature of the cell cycle in neurons: Focus on a "non-canonical" pathway of DNA replication causally related to death (481 views)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2007 Apr; 1772(4): 409-412.
Impact Factor: 3.078
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Ronga L, Langella E, Palladino P, Marasco D, Tizzano B, Saviano M, Pedone C, Improta R, Ruvo M
* Does Tetracycline Bind Helix 2 Of Prion? An Integrated Spectroscopical And Computational Study Of The Interaction Between The Antibiotic And Alpha Helix 2 Human Prion Protein Fragments (512 views)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2007 Feb 15; 66(3): 707-715.
Impact Factor: 3.354
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Pappalardo G, Milardi D, Magrì A, Attanasio F, Impellizzeri G, La Rosa C, Grasso D, Rizzarelli E
* Environmental factors differently affect human and rat IAPP: Conformational preferences and membrane interactions of IAPP17-29 peptide derivatives (607 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2007; 13(36): 10204-10215.
Impact Factor: 5.33
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Aloj L, Aurilio M, Rinaldi V, D'Ambrosio L, Tesauro D, Peitl PK, Maina T, Mansi R, Von Guggenberg E, Joosten L, Sosabowski JK, Breeman WA, De Blois E, Koelewijn S, Melis M, Waser B, Beetschen K, Reubi JC, De Jong M
* The EEE project (449 views)
Proc Int Cosm Ray Conf Icrc Universidad Nacional Autonoma De Mexico, 2007; 5(HEPART2): 977-980.
Impact Factor: 0
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Barone V, Newton MD, Improta R
* Dissociative electron transfer in donor - Peptide - Acceptor systems: Results for kinetic parameters from a density functional/polarizable continuum model (247 views)
J Phys Chem B (ISSN: 1520-6106, 1520-5207, 1520-5207electronic), 2006 Jun 29; 110(25): 12632-12639.
Impact Factor: 4.115
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Galdiero S, Falanga A, Vitiello M, Browne H, Pedone C, Galdiero M
* Fusogenic domains in herpes simplex virus type 1 glycoprotein (590 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2005 Sep 5; 280(31): 28632-28643.
Impact Factor: 5.854
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Marrazzo A, Caraci F, Salinaro ET, Su TP, Copani A, Ronsisvalle G
* Neuroprotective effects of sigma-1 receptor agonists against beta-amyloid-induced toxicity (584 views)
Neuroreport (ISSN: 0959-4965), 2005 Sep 1; 16(11): 1223-1226.
Impact Factor: 1.995
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Bucci E, Vitagliano L, Barone R, Sorrentino S, D'Alessio G, Graziano G
* On the thermal stability of the two dimeric forms of ribonuclease (417 views)
Biophys Chem (ISSN: 0301-4622, 0301-4622linking), 2005 Jul 1; 116(2): 89-95.
Impact Factor: 1.925
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Picone D, Di Fiore A, Ercole C, Franzese M, Sica F, Tomaselli S, Mazzarella L
* The role of the hinge loop in domain swapping - The special case of bovine seminal ribonuclease (367 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2005 Apr 8; 280(14): 13771-13778.
Impact Factor: 5.854
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De Luca S, Sanseverino M, Zocchi I, Pedone C, Morelli G, Ragone R
* Receptor fragment approach to the binding between CCK8 peptide and cholecystokinin receptors: A fluorescence study on type B receptor fragment CCKB-R (352-379) (359 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2005 Mar; 77(4): 205-211.
Impact Factor: 2.545
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Barone V, Formaggio F, Improta R, Polo F, Maran F
* Electron transfer to and conformational preferences of Aib oligo-peptides (385 views)
Proc Electrochem Soc, 2004; 10: 29-32.
Impact Factor: 0
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De Luca S, Ragone R, Bracco C, Digilio G, Aloj L, Tesauro D, Saviano M, Pedone C, Morelli G
* A cyclic CCK8 analogue selective for the cholecystokinin type A receptor: design, synthesis, NMR structure and binding measurements (472 views)
Chembiochem (ISSN: 1439-7633, 1439-4227, 1439-7633electronic), 2003 Nov 7; 4(11): 1176-1187.
Impact Factor: 3.992
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Portella G, Pacelli R, Libertini S, Cella L, Vecchio G, Salvatore M, Fusco A
* ONYX-015 Enhances Radiation-Induced Death of Human Anaplastic Thyroid Carcinoma Cells (467 views)
J Clin Endocrinol Metab Journal Of Clinical Endocrinology And Metabolism (ISSN: 0021-972x), 2003 Oct 1; 88(10): 5027-5032.
Impact Factor: 5.873
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Russo M, Palumbo R, Mupo A, Tosto M, Iacomino G, Scognamiglio A, Tedesco I, Galano G, Russo GL
* Flavonoid quercetin sensitizes a CD95-resistant cell line to apoptosis by activating protein kinase Cα (437 views)
Oncogene (ISSN: 0950-9232, 1476-5594), 2003; 22(21): 3330-3342.
Impact Factor: 6.495
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Aloj L, Panico M, Caracó C, Zannetti A, Del Vecchio S, Di Nuzzo C, Arra C, Morelli G, Tesauro D, De Luca S, Pedone C, Salvatore M
* Radiolabeling approaches for cholecystokinin B receptor imaging (496 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2002; 66(6): 370-380.
Impact Factor: 2.372
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Saracino GAA, Tedeschi A, D'Errico G, Improta R, Franco L, Ruzzi M, Corvaia C, Barone V
* Solvent polarity and pH effects on the magnetic properties of ionizable nitroxide radicals: A combined computational and experimental study of 2, 2, 5, 5-tetramethyl-3-carboxypyrrolidine and 2, 2, 6, 6-tetramethyl-4-carboxypiperidine nitroxides (280 views)
J Phys Chem A (ISSN: 1089-5639, 1520-5215electronic), 2002; 106(44): 10700-10706.
Impact Factor: 2.765
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De Falco S, Ruvoletto MG, Verdoliva A, Ruvo M, Raucci A, Marino M, Senatore S, Cassani G, Alberti A, Pontisso P, Fassina G
* Cloning and Expression of a Novel Hepatitis B Virus-binding Protein from HepG2 Cells (622 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2001 Sep 28; 276(39): 36613-36623.
Impact Factor: 7.258
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Ragone R, De Luca S, Tesauro D, Pedone C, Morelli G
Fluorescence studies on the binding between 1-47 fragment of cholecystokinin receptor CCKA-R(1-47) and nonsulfated cholecystokinin octapeptide CCK8 (419 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2000; 56(1): 47-53.
Impact Factor: 2.405
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Gallo P, Rossi F, Saviano M, Pedone C, Colonna G, Ragone R
Specific interaction between bovine cyclophilin A and synthetic analogues of cyclolinopeptide (393 views)
Journal Of Biochemistry (ISSN: 0021-924x), 1998 Nov; 124(5): 880-885.
Impact Factor: 2.189
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Wink DA, Cook JA, Pacelli R, DeGraff W, Gamson J, Liebmann J, Krishna MC, Mitchell JB
The effect of various nitric oxide-donor agents on hydrogen peroxide-mediated toxicity: A direct correlation between nitric oxide formation and protection (685 views)
Arch Bioch Bioph (ISSN: 0003-9861, 0003-9861linking), 1996 Jul 15; 331(2): 241-248.
Impact Factor: 2.649
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Levchenko A, Mehta B, Spengler BA, Narkar A, Fonti R, Biedler JL, Tsuruo T, Larson SM
Measurement of P-glycoprotein expression in multidrug-resistant human neuroblastoma cell lines using self-competitive binding assay (283 views)
Anal Biochem (ISSN: 0003-2697, 1096-0309electronic, 0003-2697linking), 1996 May 1; 236(2): 338-343.
Impact Factor: 2.017
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Arena G, Bindoni M, Cardile V, Maccarrone G, Riello MC, Rizzarelli E, Sciuto S
Cytotoxic and cytostatic activity of copper(II) complexes. Importance of the speciation for the correct interpretation of the in vitro biological results (477 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 1993 Apr 1; 50(1): 31-45.
Impact Factor: 1.342
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89 Records (86 excluding Abstracts).
Total impact factor: 369.598 (356.997 excluding Abstracts).
Total 5 year impact factor: 336.042 (327.116 excluding Abstracts).
Total impact factor: 369.598 (356.997 excluding Abstracts).
Total 5 year impact factor: 336.042 (327.116 excluding Abstracts).
394 views. Last view on Monday 30 January 2023, 14:18:20
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