Longitudinal study of thyroid function in children with mild hyperthyrotropinemia at neonatal screening for congenital hypothyroidism(315 views) Leonardi D, Polizzotti N, Carta A, Gelsomino R, Sava L, Vigneri R, Calaciura F
Endocrinologia, Dipartimento di Medicina Interna e Medicina Specialistica, Ospedale Garibaldi-Nesima, 95122 Catania, Italy
Endocrinologia-Università di Catania, Ospedale Garibaldi-Nesima, Via Palermo 636, 95122 Catania, Italy
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Tyfield, L. A., Abusrewil, S. S., Jones, S. R., Savage, D. C., Persistent hyperthyreotropinaemia since the neonatal period in clinically euthyroid children (1991) Eur J Pediatr, 150, pp. 308-309
Daliva, A. L., Linder, B., Di Martino-Nardi, J., Sanger, P., Three years follow up of borderline congenital hypothyroidism (2000) J Pediatr, 136, pp. 53-56
Fisher, D. A., Management of congenital hypothyroidism (1991) J Clin Endocrinol Metab, 72, pp. 523-529
Zimmerman, M. B., Hess, S. Y., Molinari, L., deBenoist, B., Delange, F., Braverman, L. E., Fujieda, K., Shishiba, Y., New reference values for thyroid volume by ultrasound in iodine-sufficient schoolchildren: A World Health Organization/Nutrition for Health and Development Iodine Deficiency Study Group Report (2004) Am J Clin Nutr, 79, pp. 231-237
Tanner, J. M., Whitehouse, R. H., Takaishi, M., Standards from birth to maturity for height, weight, height velocity and weight velocity: British children, 1965. I, II (1966) Arch Dis Child, 41, pp. 454-471, 613-635
Guyda, H. J., Therapy of congenital hypothyroidism. Evolution of biochemical parameters (1980) Neonatal thyroid screening, pp. 247-261. , Burrow GN, Dussault JH, eds, New York: Raven Press
Moreno, J. C., Bikker, H., Kempers, M. J., van Trotsenburg, A. S., Baas, F., de Vijlder, J. J., Vulsma, T., Ris-Stalpers, C., Inactivating mutations in the gene for thyroid oxidase 2 (THOX2) and congenital hypothyroidism (2002) N Engl J Med, 347, pp. 95-102
Surks, M. I., Ocampo, E., Subclinical thyroid disease (1996) Am J Med, 100, pp. 217-223
Hak, A. E., Pols, H. A., Visser, I. J., Drexhage, H. A., Hofman, A., Witterman, J. C., Subclinical hypothyroidism is an independent risk factor for atherosclerosis and myocardial infarction in elderly women: The Rotterdam Study (2000) Ann Intern Med, 132, pp. 270-278
Chu, J. W., Crapo, L. M., The treatment of subclinical hypothyroidism is seldom necessary (2001) J Clin Endocrinol Metab, 86, pp. 4591-4599
McDermott, M. T., Ridgway, E. C., Subclinical hypothyroidism is mild thyroid failure and should be treated (2001) J Clin Endocrinol Metab, 86, pp. 4585-4590
Longitudinal study of thyroid function in children with mild hyperthyrotropinemia at neonatal screening for congenital hypothyroidism
Objective: Long-term outcome of thyroid function in children with very short-lasting neonatal hyperthyrotropinemia ("false positive" at neonatal screening) was studied in an observational, prospective study. Thyroid function and morphology were evaluated in 44 "false positive" children up to advanced childhood (8.0 +/- 0.7 yr of age). In these children a high prevalence (50%) of subclinical hypothyroidism in early childhood (2.8 +/- 0.5 yr) had already been described. Results: At an average of 5.3 yr, subclinical hypothyroidism persisted in 19 of 44 (43.2%) children and, more specifically, in two of three of those who had increased TSH in early childhood. Euthyroidism was present in all cases that were euthyroid in early childhood, although they had TSH and free T-3 values significantly higher than control children with a normal TSH at birth (TSH = 2.6 +/- 0.7 vs. 1.5 +/- 0.6 mU/liter, P < 0.001; free T-3 = 4.9 +/- 0.8 vs. 3.9 +/- 0.9 pmol/liter, P < 0.01). Thyroid morphology alterations were frequent in the group of children with subclinical hypothyroidism. At an average of 8.0 yr, subclinical hypothyroidism persisted in 14 of 44 (31.8%) children. In all other children, TSH and thyroid hormones were confirmed within the normal range. Conclusions: This prospective longitudinal study confirms that newborns "false positive" at neonatal screening have a high risk to develop persistent subclinical hypothyroidism. The prevalence of hypothyroidism decreases with increasing age, but it is still high (> 30%) in late childhood. Even those "false positive" children that maintain euthyroidism in late childhood have an average TSH value that, although within the normal range, is higher than in normal controls, a possible marker of minor congenital thyroid function abnormalities.
Longitudinal study of thyroid function in children with mild hyperthyrotropinemia at neonatal screening for congenital hypothyroidism
No results.
Longitudinal study of thyroid function in children with mild hyperthyrotropinemia at neonatal screening for congenital hypothyroidism