Mapping of the norepinephrine transporter in man using PET with (S, S)-[F-18]FMeNER-D-2 (292 views) (PDF restricted 204 views)
Neuroimage (ISSN: 1053-8119, 1053-8119linking), 2008 Sep 15; 41: 474-482.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 5.694, 5-year impact factor: 6.884
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-47949088767&partnerID=40&md5=d27fbec50ba6fad5445d76c7fdaa24ec
Keywords: Fluorine 18, Noradrenalin Transporter, Radioligand, Adult, Article, Brain Aqueduct, Brain Mapping, Brain Stem, Calculation, Clinical Article, Computer Program, Controlled Study, Human, Human Experiment, In Vivo Study, Locus Ceruleus, Mesencephalon, Normal Human, Nuclear Magnetic Resonance Imaging, Positron Emission Tomography, Priority Journal, Pulvinar, Receptor Binding, Thalamus, Validity, Morpholines, Norepinephrine Plasma Membrane Transport Proteins, Positron-Emission Tomography, Radiopharmaceuticals, Tissue Distribution,
Affiliations:
*** IBB - CNR ***
Karolinska Institutet, Department of Clinical Neuroscience, Psychiatry Section, Stockholm, Sweden
Eli-Lilly and Company, Indianapolis, IN, United States
References:
Arango, V., Underwood, M.D., Mann, J.J., Fewer pigmented neurons in the locus coeruleus of uncomplicated alcoholics (1994) Brain Res., 650, pp. 1-
Belej, T., Manji, D., Sioutis, S., Barros, H.M., Nobrega, J.N., Changes in serotonin and norepinephrine uptake sites after chronic cocaine: pre- vs. post-withdrawal effects (1996) Brain Res., 736, pp. 287-296
Biegon, A., Rainbow, T.C., Localization and characterization of [3H]desmethylimipramine binding sites in rat brain by quantitative autoradiography (1983) J. Neurosci., 3, pp. 1069-1076
Buchsbaum, M.S., Someya, T., Teng, C.Y., Abel, L., Chin, S., Najafi, A., Haier, R.J., Bunney Jr., W.E., PET and MRI of the thalamus in never-medicated patients with schizophrenia (1996) Am. J. Psychiatry, 153, pp. 191-199
Cannon, D.M., Ichise, M., Fromm, S.J., Nugent, A.C., Rollis, D., Gandhi, S.K., Klaver, J.M., Drevets, W.C., Serotonin transporter binding in bipolar disorder assessed using [11C]DASB and positron emission tomography (2006) Biol. Psychiatry, 60, pp. 207-217
Chikama, M., McFarland, N.R., Amaral, D.G., Haber, S.N., Insular cortical projections to functional regions of the striatum correlate with cortical cytoarchitectonic organization in the primate (1997) J. Neurosci., 17, pp. 9686-9705
Farde, L., Eriksson, L., Blomquist, G., Halldin, C., Kinetic analysis of central [11C]raclopride binding to D2-dopamine receptors studied by PET-a comparison to the equilibrium analysis (1989) J. Cereb. Blood Flow. Metab., 9, pp. 696-708
Foote, S.L., Bloom, F.E., Aston-Jones, G., Nucleus locus ceruleus: new evidence of anatomical and physiological specificity (1983) Physiol. Rev., 63, pp. 844-914
Heneka, M.T., Ramanathan, M., Jacobs, A.H., Dumitrescu-Ozimek, L., Bilkei-Gorzo, A., Debeir, T., Sastre, M., Staufenbiel, M., Locus ceruleus degeneration promotes Alzheimer pathogenesis in amyloid precursor protein 23 transgenic mice (2006) J. Neurosci., 26, pp. 1343-1354
Innis, R.B., Cunningham, V.J., Delforge, J., Fujita, M., Gjedde, A., Gunn, R.N., Holden, J., Carson, R.E., Consensus nomenclature for in vivo imaging of reversibly binding radioligands (2007) J. Cereb. Blood Flow Metab., 27, pp. 1533-1539
Javitch, J.A., Strittmatter, S.M., Snyder, S.H., Differential visualization of dopamine and norepinephrine uptake sites in rat brain using [3H]mazindol autoradiography (1985) J. Neurosci., 5, pp. 1513-1521
Jensen, S.B., Olsen, A.K., Pedersen, K., Cumming, P., Effect of monoamine oxidase inhibition on amphetamine-evoked changes in dopamine receptor availability in the living pig: a dual tracer PET study with [11C]harmine and [11C]raclopride (2006) Synapse, 59, pp. 427-434
Logan, J., Wang, G.J., Telang, F., Fowler, J.S., Alexoff, D., Zabroski, J., Jayne, M., Ding, Y.S., Imaging the norepinephrine transporter in humans with (S,S)-[11C]O-methyl reboxetine and PET: problems and progress (2007) Nucl. Med. Biol., 34, pp. 667-679
Lundberg, J., Borg, J., Halldin, C., Farde, L., A PET study on regional coexpression of 5-HT1A receptors and 5-HTT in the human brain (2007) Psychopharmacology (Berl.), 195, pp. 425-433
Marner, L., Søborg, C., Pakkenberg, B., Increased volume of the pigmented neurons in the locus coeruleus of schizophrenic subjects: a stereological study (2005) J. Psychiatr. Res., 39, pp. 337-345
Mash, D.C., Ouyang, Q., Qin, Y., Pablo, J., Norepinephrine transporter immunoblotting and radioligand binding in cocaine abusers (2005) J. Neurosci. Methods, 143, pp. 79-85
Mesulam, M.M., Mufson, E.J., Insula of the old world monkey. I. Architectonics in the insulo-orbito-temporal component of the paralimbic brain (1982) J. Comp. Neurol., 212, pp. 1-22
Oke, A.F., Carver, L.A., Gouvion, C.M., Adams, R.N., Three-dimensional mapping of norepinephrine and serotonin in human thalamus (1997) Brain Res., 763, pp. 69-78
Ordway, G.A., Stockmeier, C.A., Cason, G.W., Klimek, V., Pharmacology and distribution of norepinephrine transporters in the human locus coeruleus and raphe nuclei (1997) J. Neurosci., 17, pp. 1710-1719
Reig, S., Penedo, M., Gispert, J.D., Pascau, J., Sánchez-González, J., García-Barreno, P., Desco, M., Impact of ventricular enlargement on the measurement of metabolic activity in spatially normalized PET (2007) Neuroimage, 35, pp. 748-758
Schou, M., Halldin, C., Sóvágó, J., Pike, V.W., Gulyás, B., Mozley, P.D., Johnson, D.P., Farde, L., Specific in vivo binding to the norepinephrine transporter demonstrated with the PET radioligand, (S,S)-[11C]MeNER (2003) Nucl. Med. Biol., 30, pp. 707-714
Schulz, J.B., Skalej, M., Wedekind, D., Luft, A.R., Abele, M., Voigt, K., Dichgans, J., Klockgether, T., Magnetic resonance imaging-based volumetry differentiates idiopathic Parkinson's syndrome from multiple system atrophy and progressive supranuclear palsy (1999) Ann. Neurol., 45, pp. 65-74
Seneca, N., Gulyás, B., Varrone, A., Schou, M., Airaksinen, A., Tauscher, J., Vandenhende, F., Halldin, C., Atomoxetine occupies the norepinephrine transporter in a dose-dependent fashion: a PET study in nonhuman primate brain using (S,S)-[18F]FMeNER-D2 (2006) Psychopharmacology (Berl.), 188, pp. 119-127
Smith, H.R., Beveridge, T.J., Porrino, L.J., Distribution of norepinephrine transporters in the non-human primate brain (2006) Neuroscience, 138, pp. 703-714
Swanson, L.W., Hartman, B.K., The central adrenergic system. An immunofluorescence study of the location of cell bodies and their efferent connections in the rat utilizing dopamine-beta-hydroxylase as a marker (1975) J. Comp. Neurol., 163, pp. 467-505
Szabó, C.A., Lancaster, J.L., Xiong, J., Cook, C., Fox, P., MR imaging volumetry of subcortical structures and cerebellar hemispheres in normal persons (2003) A.J.N.R. Am. J. Neuroradiol., 24, pp. 644-647
Takano, A., Varrone, A., Seneca, N., Tauscher, J., Gulyás, B., Halldin, C., Comparative evaluation of quantitative analysis of the norepinephrine transporter radioligand (S,S)-[18F]FMeNER-D2 in monkey brains (2007) Eur. J. Nucl. Med. Mol. Imaging, 34 (SUPPL.2), pp. S206
Takano, A., Gulyás, B., Varrone, A., Karlsson, P., Schou, M., Airaksinen, A.J., Vandenhende, F., Halldin, C., Imaging the norepinephrine transporter with positron emission tomography: initial human studies with (S,S)-[18F]FMeNER-D2 (2008) Eur. J. Nucl. Med. Mol. Imaging, 35, pp. 153-157
Tejani-Butt, S.M., [3H]nisoxetine: a radioligand for quantitation of norepinephrine uptake sites by autoradiography or by homogenate binding (1992) J. Pharmacol. Exp. Ther., 260, pp. 427-436
Yasui, Y., Breder, C.D., Saper, C.B., Cechetto, D.F., Autonomic responses and efferent pathways from the insular cortex in the rat (1991) J. Comp. Neurol., 303, pp. 355-374
Yasuno, F., Suhara, T., Okubo, Y., Sudo, Y., Inoue, M., Ichimiya, T., Takano, A., Farde, L., Low dopamine D2 receptor binding in subregions of the thalamus in schizophrenia (2004) Am. J. Psychiatry, 161, pp. 1016-1022
Buchsbaum, M. S., Someya, T., Teng, C. Y., Abel, L., Chin, S., Najafi, A., Haier, R. J., Bunney Jr., W. E., PET and MRI of the thalamus in never-medicated patients with schizophrenia (1996) Am. J. Psychiatry, 153, pp. 191-199
Cannon, D. M., Ichise, M., Fromm, S. J., Nugent, A. C., Rollis, D., Gandhi, S. K., Klaver, J. M., Drevets, W. C., Serotonin transporter binding in bipolar disorder assessed using [11C] DASB and positron emission tomography (2006) Biol. Psychiatry, 60, pp. 207-217
Foote, S. L., Bloom, F. E., Aston-Jones, G., Nucleus locus ceruleus: new evidence of anatomical and physiological specificity (1983) Physiol. Rev., 63, pp. 844-914
Heneka, M. T., Ramanathan, M., Jacobs, A. H., Dumitrescu-Ozimek, L., Bilkei-Gorzo, A., Debeir, T., Sastre, M., Staufenbiel, M., Locus ceruleus degeneration promotes Alzheimer pathogenesis in amyloid precursor protein 23 transgenic mice (2006) J. Neurosci., 26, pp. 1343-1354
Innis, R. B., Cunningham, V. J., Delforge, J., Fujita, M., Gjedde, A., Gunn, R. N., Holden, J., Carson, R. E., Consensus nomenclature for in vivo imaging of reversibly binding radioligands (2007) J. Cereb. Blood Flow Metab., 27, pp. 1533-1539
Javitch, J. A., Strittmatter, S. M., Snyder, S. H., Differential visualization of dopamine and norepinephrine uptake sites in rat brain using [3H] mazindol autoradiography (1985) J. Neurosci., 5, pp. 1513-1521
Jensen, S. B., Olsen, A. K., Pedersen, K., Cumming, P., Effect of monoamine oxidase inhibition on amphetamine-evoked changes in dopamine receptor availability in the living pig: a dual tracer PET study with [11C] harmine and [11C] raclopride (2006) Synapse, 59, pp. 427-434
Marner, L., S borg, C., Pakkenberg, B., Increased volume of the pigmented neurons in the locus coeruleus of schizophrenic subjects: a stereological study (2005) J. Psychiatr. Res., 39, pp. 337-345
Mash, D. C., Ouyang, Q., Qin, Y., Pablo, J., Norepinephrine transporter immunoblotting and radioligand binding in cocaine abusers (2005) J. Neurosci. Methods, 143, pp. 79-85
Mesulam, M. M., Mufson, E. J., Insula of the old world monkey. I. Architectonics in the insulo-orbito-temporal component of the paralimbic brain (1982) J. Comp. Neurol., 212, pp. 1-22
Oke, A. F., Carver, L. A., Gouvion, C. M., Adams, R. N., Three-dimensional mapping of norepinephrine and serotonin in human thalamus (1997) Brain Res., 763, pp. 69-78
Ordway, G. A., Stockmeier, C. A., Cason, G. W., Klimek, V., Pharmacology and distribution of norepinephrine transporters in the human locus coeruleus and raphe nuclei (1997) J. Neurosci., 17, pp. 1710-1719
Schulz, J. B., Skalej, M., Wedekind, D., Luft, A. R., Abele, M., Voigt, K., Dichgans, J., Klockgether, T., Magnetic resonance imaging-based volumetry differentiates idiopathic Parkinson's syndrome from multiple system atrophy and progressive supranuclear palsy (1999) Ann. Neurol., 45, pp. 65-74
Seneca, N., Guly s, B., Varrone, A., Schou, M., Airaksinen, A., Tauscher, J., Vandenhende, F., Halldin, C., Atomoxetine occupies the norepinephrine transporter in a dose-dependent fashion: a PET study in nonhuman primate brain using (S, S) - [18F] FMeNER-D2 (2006) Psychopharmacology (Berl.), 188, pp. 119-127
Smith, H. R., Beveridge, T. J., Porrino, L. J., Distribution of norepinephrine transporters in the non-human primate brain (2006) Neuroscience, 138, pp. 703-714
Swanson, L. W., Hartman, B. K., The central adrenergic system. An immunofluorescence study of the location of cell bodies and their efferent connections in the rat utilizing dopamine-beta-hydroxylase as a marker (1975) J. Comp. Neurol., 163, pp. 467-505
Szab, C. A., Lancaster, J. L., Xiong, J., Cook, C., Fox, P., MR imaging volumetry of subcortical structures and cerebellar hemispheres in normal persons (2003) A. J. N. R. Am. J. Neuroradiol., 24, pp. 644-647
Takano, A., Guly s, B., Varrone, A., Karlsson, P., Schou, M., Airaksinen, A. J., Vandenhende, F., Halldin, C., Imaging the norepinephrine transporter with positron emission tomography: initial human studies with (S, S) - [18F] FMeNER-D2 (2008) Eur. J. Nucl. Med. Mol. Imaging, 35, pp. 153-157
Tejani-Butt, S. M., [3H] nisoxetine: a radioligand for quantitation of norepinephrine uptake sites by autoradiography or by homogenate binding (1992) J. Pharmacol. Exp. Ther., 260, pp. 427-436
Neuroimage (ISSN: 1053-8119, 1053-8119linking), 2008 Sep 15; 41: 474-482.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 5.694, 5-year impact factor: 6.884
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-47949088767&partnerID=40&md5=d27fbec50ba6fad5445d76c7fdaa24ec
Keywords: Fluorine 18, Noradrenalin Transporter, Radioligand, Adult, Article, Brain Aqueduct, Brain Mapping, Brain Stem, Calculation, Clinical Article, Computer Program, Controlled Study, Human, Human Experiment, In Vivo Study, Locus Ceruleus, Mesencephalon, Normal Human, Nuclear Magnetic Resonance Imaging, Positron Emission Tomography, Priority Journal, Pulvinar, Receptor Binding, Thalamus, Validity, Morpholines, Norepinephrine Plasma Membrane Transport Proteins, Positron-Emission Tomography, Radiopharmaceuticals, Tissue Distribution,
Affiliations:
*** IBB - CNR ***
Karolinska Institutet, Department of Clinical Neuroscience, Psychiatry Section, Stockholm, Sweden
Eli-Lilly and Company, Indianapolis, IN, United States
References:
Arango, V., Underwood, M.D., Mann, J.J., Fewer pigmented neurons in the locus coeruleus of uncomplicated alcoholics (1994) Brain Res., 650, pp. 1-
Belej, T., Manji, D., Sioutis, S., Barros, H.M., Nobrega, J.N., Changes in serotonin and norepinephrine uptake sites after chronic cocaine: pre- vs. post-withdrawal effects (1996) Brain Res., 736, pp. 287-296
Biegon, A., Rainbow, T.C., Localization and characterization of [3H]desmethylimipramine binding sites in rat brain by quantitative autoradiography (1983) J. Neurosci., 3, pp. 1069-1076
Buchsbaum, M.S., Someya, T., Teng, C.Y., Abel, L., Chin, S., Najafi, A., Haier, R.J., Bunney Jr., W.E., PET and MRI of the thalamus in never-medicated patients with schizophrenia (1996) Am. J. Psychiatry, 153, pp. 191-199
Cannon, D.M., Ichise, M., Fromm, S.J., Nugent, A.C., Rollis, D., Gandhi, S.K., Klaver, J.M., Drevets, W.C., Serotonin transporter binding in bipolar disorder assessed using [11C]DASB and positron emission tomography (2006) Biol. Psychiatry, 60, pp. 207-217
Chikama, M., McFarland, N.R., Amaral, D.G., Haber, S.N., Insular cortical projections to functional regions of the striatum correlate with cortical cytoarchitectonic organization in the primate (1997) J. Neurosci., 17, pp. 9686-9705
Farde, L., Eriksson, L., Blomquist, G., Halldin, C., Kinetic analysis of central [11C]raclopride binding to D2-dopamine receptors studied by PET-a comparison to the equilibrium analysis (1989) J. Cereb. Blood Flow. Metab., 9, pp. 696-708
Foote, S.L., Bloom, F.E., Aston-Jones, G., Nucleus locus ceruleus: new evidence of anatomical and physiological specificity (1983) Physiol. Rev., 63, pp. 844-914
Heneka, M.T., Ramanathan, M., Jacobs, A.H., Dumitrescu-Ozimek, L., Bilkei-Gorzo, A., Debeir, T., Sastre, M., Staufenbiel, M., Locus ceruleus degeneration promotes Alzheimer pathogenesis in amyloid precursor protein 23 transgenic mice (2006) J. Neurosci., 26, pp. 1343-1354
Innis, R.B., Cunningham, V.J., Delforge, J., Fujita, M., Gjedde, A., Gunn, R.N., Holden, J., Carson, R.E., Consensus nomenclature for in vivo imaging of reversibly binding radioligands (2007) J. Cereb. Blood Flow Metab., 27, pp. 1533-1539
Javitch, J.A., Strittmatter, S.M., Snyder, S.H., Differential visualization of dopamine and norepinephrine uptake sites in rat brain using [3H]mazindol autoradiography (1985) J. Neurosci., 5, pp. 1513-1521
Jensen, S.B., Olsen, A.K., Pedersen, K., Cumming, P., Effect of monoamine oxidase inhibition on amphetamine-evoked changes in dopamine receptor availability in the living pig: a dual tracer PET study with [11C]harmine and [11C]raclopride (2006) Synapse, 59, pp. 427-434
Logan, J., Wang, G.J., Telang, F., Fowler, J.S., Alexoff, D., Zabroski, J., Jayne, M., Ding, Y.S., Imaging the norepinephrine transporter in humans with (S,S)-[11C]O-methyl reboxetine and PET: problems and progress (2007) Nucl. Med. Biol., 34, pp. 667-679
Lundberg, J., Borg, J., Halldin, C., Farde, L., A PET study on regional coexpression of 5-HT1A receptors and 5-HTT in the human brain (2007) Psychopharmacology (Berl.), 195, pp. 425-433
Marner, L., Søborg, C., Pakkenberg, B., Increased volume of the pigmented neurons in the locus coeruleus of schizophrenic subjects: a stereological study (2005) J. Psychiatr. Res., 39, pp. 337-345
Mash, D.C., Ouyang, Q., Qin, Y., Pablo, J., Norepinephrine transporter immunoblotting and radioligand binding in cocaine abusers (2005) J. Neurosci. Methods, 143, pp. 79-85
Mesulam, M.M., Mufson, E.J., Insula of the old world monkey. I. Architectonics in the insulo-orbito-temporal component of the paralimbic brain (1982) J. Comp. Neurol., 212, pp. 1-22
Oke, A.F., Carver, L.A., Gouvion, C.M., Adams, R.N., Three-dimensional mapping of norepinephrine and serotonin in human thalamus (1997) Brain Res., 763, pp. 69-78
Ordway, G.A., Stockmeier, C.A., Cason, G.W., Klimek, V., Pharmacology and distribution of norepinephrine transporters in the human locus coeruleus and raphe nuclei (1997) J. Neurosci., 17, pp. 1710-1719
Reig, S., Penedo, M., Gispert, J.D., Pascau, J., Sánchez-González, J., García-Barreno, P., Desco, M., Impact of ventricular enlargement on the measurement of metabolic activity in spatially normalized PET (2007) Neuroimage, 35, pp. 748-758
Schou, M., Halldin, C., Sóvágó, J., Pike, V.W., Gulyás, B., Mozley, P.D., Johnson, D.P., Farde, L., Specific in vivo binding to the norepinephrine transporter demonstrated with the PET radioligand, (S,S)-[11C]MeNER (2003) Nucl. Med. Biol., 30, pp. 707-714
Schulz, J.B., Skalej, M., Wedekind, D., Luft, A.R., Abele, M., Voigt, K., Dichgans, J., Klockgether, T., Magnetic resonance imaging-based volumetry differentiates idiopathic Parkinson's syndrome from multiple system atrophy and progressive supranuclear palsy (1999) Ann. Neurol., 45, pp. 65-74
Seneca, N., Gulyás, B., Varrone, A., Schou, M., Airaksinen, A., Tauscher, J., Vandenhende, F., Halldin, C., Atomoxetine occupies the norepinephrine transporter in a dose-dependent fashion: a PET study in nonhuman primate brain using (S,S)-[18F]FMeNER-D2 (2006) Psychopharmacology (Berl.), 188, pp. 119-127
Smith, H.R., Beveridge, T.J., Porrino, L.J., Distribution of norepinephrine transporters in the non-human primate brain (2006) Neuroscience, 138, pp. 703-714
Swanson, L.W., Hartman, B.K., The central adrenergic system. An immunofluorescence study of the location of cell bodies and their efferent connections in the rat utilizing dopamine-beta-hydroxylase as a marker (1975) J. Comp. Neurol., 163, pp. 467-505
Szabó, C.A., Lancaster, J.L., Xiong, J., Cook, C., Fox, P., MR imaging volumetry of subcortical structures and cerebellar hemispheres in normal persons (2003) A.J.N.R. Am. J. Neuroradiol., 24, pp. 644-647
Takano, A., Varrone, A., Seneca, N., Tauscher, J., Gulyás, B., Halldin, C., Comparative evaluation of quantitative analysis of the norepinephrine transporter radioligand (S,S)-[18F]FMeNER-D2 in monkey brains (2007) Eur. J. Nucl. Med. Mol. Imaging, 34 (SUPPL.2), pp. S206
Takano, A., Gulyás, B., Varrone, A., Karlsson, P., Schou, M., Airaksinen, A.J., Vandenhende, F., Halldin, C., Imaging the norepinephrine transporter with positron emission tomography: initial human studies with (S,S)-[18F]FMeNER-D2 (2008) Eur. J. Nucl. Med. Mol. Imaging, 35, pp. 153-157
Tejani-Butt, S.M., [3H]nisoxetine: a radioligand for quantitation of norepinephrine uptake sites by autoradiography or by homogenate binding (1992) J. Pharmacol. Exp. Ther., 260, pp. 427-436
Yasui, Y., Breder, C.D., Saper, C.B., Cechetto, D.F., Autonomic responses and efferent pathways from the insular cortex in the rat (1991) J. Comp. Neurol., 303, pp. 355-374
Yasuno, F., Suhara, T., Okubo, Y., Sudo, Y., Inoue, M., Ichimiya, T., Takano, A., Farde, L., Low dopamine D2 receptor binding in subregions of the thalamus in schizophrenia (2004) Am. J. Psychiatry, 161, pp. 1016-1022
Buchsbaum, M. S., Someya, T., Teng, C. Y., Abel, L., Chin, S., Najafi, A., Haier, R. J., Bunney Jr., W. E., PET and MRI of the thalamus in never-medicated patients with schizophrenia (1996) Am. J. Psychiatry, 153, pp. 191-199
Cannon, D. M., Ichise, M., Fromm, S. J., Nugent, A. C., Rollis, D., Gandhi, S. K., Klaver, J. M., Drevets, W. C., Serotonin transporter binding in bipolar disorder assessed using [11C] DASB and positron emission tomography (2006) Biol. Psychiatry, 60, pp. 207-217
Foote, S. L., Bloom, F. E., Aston-Jones, G., Nucleus locus ceruleus: new evidence of anatomical and physiological specificity (1983) Physiol. Rev., 63, pp. 844-914
Heneka, M. T., Ramanathan, M., Jacobs, A. H., Dumitrescu-Ozimek, L., Bilkei-Gorzo, A., Debeir, T., Sastre, M., Staufenbiel, M., Locus ceruleus degeneration promotes Alzheimer pathogenesis in amyloid precursor protein 23 transgenic mice (2006) J. Neurosci., 26, pp. 1343-1354
Innis, R. B., Cunningham, V. J., Delforge, J., Fujita, M., Gjedde, A., Gunn, R. N., Holden, J., Carson, R. E., Consensus nomenclature for in vivo imaging of reversibly binding radioligands (2007) J. Cereb. Blood Flow Metab., 27, pp. 1533-1539
Javitch, J. A., Strittmatter, S. M., Snyder, S. H., Differential visualization of dopamine and norepinephrine uptake sites in rat brain using [3H] mazindol autoradiography (1985) J. Neurosci., 5, pp. 1513-1521
Jensen, S. B., Olsen, A. K., Pedersen, K., Cumming, P., Effect of monoamine oxidase inhibition on amphetamine-evoked changes in dopamine receptor availability in the living pig: a dual tracer PET study with [11C] harmine and [11C] raclopride (2006) Synapse, 59, pp. 427-434
Marner, L., S borg, C., Pakkenberg, B., Increased volume of the pigmented neurons in the locus coeruleus of schizophrenic subjects: a stereological study (2005) J. Psychiatr. Res., 39, pp. 337-345
Mash, D. C., Ouyang, Q., Qin, Y., Pablo, J., Norepinephrine transporter immunoblotting and radioligand binding in cocaine abusers (2005) J. Neurosci. Methods, 143, pp. 79-85
Mesulam, M. M., Mufson, E. J., Insula of the old world monkey. I. Architectonics in the insulo-orbito-temporal component of the paralimbic brain (1982) J. Comp. Neurol., 212, pp. 1-22
Oke, A. F., Carver, L. A., Gouvion, C. M., Adams, R. N., Three-dimensional mapping of norepinephrine and serotonin in human thalamus (1997) Brain Res., 763, pp. 69-78
Ordway, G. A., Stockmeier, C. A., Cason, G. W., Klimek, V., Pharmacology and distribution of norepinephrine transporters in the human locus coeruleus and raphe nuclei (1997) J. Neurosci., 17, pp. 1710-1719
Schulz, J. B., Skalej, M., Wedekind, D., Luft, A. R., Abele, M., Voigt, K., Dichgans, J., Klockgether, T., Magnetic resonance imaging-based volumetry differentiates idiopathic Parkinson's syndrome from multiple system atrophy and progressive supranuclear palsy (1999) Ann. Neurol., 45, pp. 65-74
Seneca, N., Guly s, B., Varrone, A., Schou, M., Airaksinen, A., Tauscher, J., Vandenhende, F., Halldin, C., Atomoxetine occupies the norepinephrine transporter in a dose-dependent fashion: a PET study in nonhuman primate brain using (S, S) - [18F] FMeNER-D2 (2006) Psychopharmacology (Berl.), 188, pp. 119-127
Smith, H. R., Beveridge, T. J., Porrino, L. J., Distribution of norepinephrine transporters in the non-human primate brain (2006) Neuroscience, 138, pp. 703-714
Swanson, L. W., Hartman, B. K., The central adrenergic system. An immunofluorescence study of the location of cell bodies and their efferent connections in the rat utilizing dopamine-beta-hydroxylase as a marker (1975) J. Comp. Neurol., 163, pp. 467-505
Szab, C. A., Lancaster, J. L., Xiong, J., Cook, C., Fox, P., MR imaging volumetry of subcortical structures and cerebellar hemispheres in normal persons (2003) A. J. N. R. Am. J. Neuroradiol., 24, pp. 644-647
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Mapping of the norepinephrine transporter in man using PET with (S, S)-[F-18]FMeNER-D-2
We have evaluated the detailed mapping of the norepinephrine transporter (NET) in the human brain with (S, S)-[(18)F]FMeNER-D(2) using a template method and the generation of functional ROIs based on the PET information. Brain PET measurements were performed from 90 to 210 min after the injection of (S,S)-[(18)F] FMeNER-D2 in 20 healthy male Subjects. Binding potential (BP(ND)) was calculated as late time ratio of the target region to the reference region (caudate) minus one. BP(ND) template images were generated from mean parametric images obtained in a group of 10 Subjects Using SPM2. On the BP(ND)/MRI template images, functional ROIs based on several different BP(ND) thresholds for the thalamus and brainstem were generated automatically using PMOD 2.8 software in addition to anatomical ROIs. PET/MRI data of another group Of 10 subjects were used to evaluate the validity of the template method and the functional ROIs. NET BPND template images demonstrated higher binding in the media[ thalamus whereas the anterior and the pulvinar divisions had lower binding. In the brainstem, high binding was detected around the cerebral aqueduct of the midbrain and within the dorsal pons, in a volume comprising locus coeruleus. Functional ROIs with higher BP(ND) thresholds naturally yielded higher BPND and lower coefficients of variance than did anatomical ROIs. This study indicated that (S,S)-[(18)F]FMeNER-D(2) combined with a template method provides detailed information on the distribution of NET in vivo and that functional ROIs on the template would be useful in further clinical studies. (C) 2008 Elsevier Inc. All rights reserved.
We have evaluated the detailed mapping of the norepinephrine transporter (NET) in the human brain with (S, S)-[(18)F]FMeNER-D(2) using a template method and the generation of functional ROIs based on the PET information. Brain PET measurements were performed from 90 to 210 min after the injection of (S,S)-[(18)F] FMeNER-D2 in 20 healthy male Subjects. Binding potential (BP(ND)) was calculated as late time ratio of the target region to the reference region (caudate) minus one. BP(ND) template images were generated from mean parametric images obtained in a group of 10 Subjects Using SPM2. On the BP(ND)/MRI template images, functional ROIs based on several different BP(ND) thresholds for the thalamus and brainstem were generated automatically using PMOD 2.8 software in addition to anatomical ROIs. PET/MRI data of another group Of 10 subjects were used to evaluate the validity of the template method and the functional ROIs. NET BPND template images demonstrated higher binding in the media[ thalamus whereas the anterior and the pulvinar divisions had lower binding. In the brainstem, high binding was detected around the cerebral aqueduct of the midbrain and within the dorsal pons, in a volume comprising locus coeruleus. Functional ROIs with higher BP(ND) thresholds naturally yielded higher BPND and lower coefficients of variance than did anatomical ROIs. This study indicated that (S,S)-[(18)F]FMeNER-D(2) combined with a template method provides detailed information on the distribution of NET in vivo and that functional ROIs on the template would be useful in further clinical studies. (C) 2008 Elsevier Inc. All rights reserved.
Mapping of the norepinephrine transporter in man using PET with (S, S)-[F-18]FMeNER-D-2
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Mapping of the norepinephrine transporter in man using PET with (S, S)-[F-18]FMeNER-D-2
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Wang H, Maurea S, Mainolfi C, Fiore F, Gravina A, Panico M, Bazzicalupo L, Salvatore M
Tc-99m MIBI scintigraphy in patients with lung cancer comparison with CT and fluorine-18 FDG PET imaging (302 views)
Clin Nucl Med (ISSN: 0363-9762, 1536-0229, 1536-0229electronic), 1997 Apr; 22(4): 243-249.
Impact Factor: 0.34
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Alfano B, Brunetti A
Advances in brain imaging: A new ethical challenge (288 views) (PDF 390 views)
Ann Ist Super Sanita (ISSN: 0021-2571), 1997; 33(4): 483-488.
Impact Factor: 0.343
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* RESUME(N): A flexible class of multi-parameter qMRI protocols (15 views)
Phys Med (ISSN: 1120-1797linking), 2021 Aug; 88: 23-36.
Impact Factor: 2.685
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Caminiti SP, Sala A, Presotto L, Chincarini A, Sestini S, Perani D, Schillaci O, Berti V, Calcagni ML, Cistaro A, Morbelli S, Nobili F, Pappata S, Volterrani D, Gobbo CL
* Validation of FDG-PET datasets of normal controls for the extraction of SPM-based brain metabolism maps (6 views)
Eur J Nucl Med Mol Imaging (ISSN: 1619-7070linking), 2021 Jul; 48(8): 2486-2499.
Impact Factor: 9.236
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Pontillo G, Tozza S, Perillo T, Cocozza S, Dubbioso R, Severi D, Iodice R, Tedeschi E, Elefante A, Brunetti A, Manganelli F, Quarantelli M
* Diffuse brain connectivity changes in Charcot-Marie-Tooth type 1a patients: a resting-state functional magnetic resonance imaging study (75 views)
Eur J Neurol (ISSN: 1351-5101linking, 1468-1331electronic), 2021 Jan; 28(1): 305-313.
Impact Factor: 4.516
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Sarappa C, Salvatore E, Filla A, Cocozza S, Russo CV, Sacca F, Brunetti A, De Michele G, Quarantelli M
* Functional MRI signal fluctuations highlight altered resting brain activity in Huntington's disease (329 views)
Brain Imaging Behav (ISSN: 1931-7557), 2017 Oct; 11(5): 1459-1469.
Impact Factor: 3.719
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Cocozza S, Pisani A, Olivo G, Saccà F, Ugga L, Riccio E, Migliaccio S, Brescia Morra V, Brunetti A, Quarantelli M, Tedeschi E
* Alterations of functional connectivity of the motor cortex in Fabry disease: An RS-fMRI study (422 views)
Neurology (ISSN: 0028-3878, 1526-632x, 0028-3878linking), 2017; 88(19): 1822-1829.
Impact Factor: 8.055
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Longarzo M, Quarantelli M, Aiello M, Romano M, Del Prete A, Cimminiello C, Cocozza S, Olivo G, Loguercio C, Trojano L, Grossi D
* The influence of interoceptive awareness on functional connectivity in patients with irritable bowel syndrome (317 views)
Brain Imaging Behav (ISSN: 1931-7557), 2016 Oct 4; 11(4): 1117-1128.
Impact Factor: 3.985
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Palma G, Tedeschi E, Borrelli P, Cocozza S, Russo C, Liu S, Ye Y, Comerci M, Alfano B, Salvatore M, Haacke EM, Mancini M
* A Novel Multiparametric Approach to 3D Quantitative MRI of the Brain (632 views) (PDF 260 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2015 Aug 18; 10(8): e0134963-e0134963.
Impact Factor: 3.057
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Mucci A, Dima D, Soricelli A, Volpe U, Bucci P, Frangou S, Prinster A, Salvatore M, Galderisi S, Maj M
* Is avolition in schizophrenia associated with a deficit of dorsal caudate activity? A functional magnetic resonance imaging study during reward anticipation and feedback (356 views)
Psychol Med (ISSN: 0033-2917), 2015 Jan 12; 45(8): 1765-1778.
Impact Factor: 5.491
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Perani D, Della Rosa PA, Cerami C, Gallivanone F, Fallanca F, Vanoli EG, Panzacchi A, Nobili F, Pappata S, Marcone A, Garibotto V, Castiglioni I, Magnani G, Cappa SF, Gianolli L; EADC-PET Consortium
* Validation of an optimized SPM procedure for FDG-PET in dementia diagnosis in a clinical setting (494 views)
Neuroimage Clin (ISSN: 2213-1582, 2213-1582electronic, 2213-1582linking), 2014 Oct 24; 6: 445-454.
Impact Factor: 2.526
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Borrelli P, Palma G, Tedeschi E, Cocozza S, Russo C, Comerci M, Alfano B, Haacke EM, Salvatore M
* Improving SNR in Susceptibility Weighted Imaging by a NLM-based denoising scheme (444 views) (PDF 249 views)
2014 Ieee Int Conf Imaging Syst Tech Proc (ISSN: 9781-479967483), 2014 Oct; 10.1109/IST.2014: 346-350.
Impact Factor: 0
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Conson M, Cella L, Pacelli R, Comerci M, Liuzzi R, Salvatore M, Quarantelli M
* Automated delineation of brain structures in patients undergoing radiotherapy for primary brain tumors: From atlas to dose-volume histograms (797 views) (PDF 377 views)
Radiother Oncol (ISSN: 0167-8140, 1879-0887, 0167-8140linking), 2014 Sep; 112(3): 326-331.
Impact Factor: 4.363
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Grossi D, Grossi D, Soricelli A, Ponari M, Salvatore E, Quarantelli M, Prinster A, Trojano L
* Structural Connectivity In A Single Case Of Progressive Prosopagnosia: The Role Of The Right Inferior Longitudinal Fasciculus (512 views)
Cortex (ISSN: 0010-9452), 2014 Jul; 56: 111-120.
Impact Factor: 5.128
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Quarantelli M, Salvatore E, Giorgio SM, Filla A, Cervo A, Russo CV, Cocozza S, Massarelli M, Brunetti A, De Michele G
* Default-mode network changes in Huntington's disease: an integrated MRI study of functional connectivity and morphometry (513 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2013 Aug 19; 8(8): e72159-e72159.
Impact Factor: 3.534
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Storto G, Gallicchio R, Pellegrino T, Nardelli A, Capacchione D, Sirignano C, Pace L
* Impact of F-18-fluoride PET-CT on implementing early treatment of painful bone metastases with Sm-153 EDTMP (346 views) (PDF 10 views)
Nucl Med Biol (ISSN: 0969-8051, 0883-2897, 0969-8051linking), 2013 May; 40(4): 518-523.
Impact Factor: 2.408
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Sasaki T, Ito H, Kimura Y, Arakawa R, Takano H, Seki C, Kodaka F, Fujie S, Takahata K, Nogami T, Suzuki M, Fujiwara H, Takahashi H, Nakao R, Fukumura T, Varrone A, Halldin C, Nishikawa T, Suhara T
* Quantification of dopamine transporter in human brain using PET with 18F-FE-PE2I (460 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 2012 Jul; 53(7): 1065-1073.
Impact Factor: 5.774
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Takano A, Gulyas B, Varrone A, Karlsson P, Sjoholm N, Larsson S, Jonsson C, Odh R, Sparks R, Al Tawil N, Hoffmann A, Zimmermann T, Thiele A, Halldin C
* Biodistribution and radiation dosimetry of the 18 kDa translocator protein (TSPO) radioligand [ 18F]FEDAA1106: A human whole-body PET study (419 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2011 Nov; 38(11): 2058-2065.
Impact Factor: 4.991
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Pappata S, Santangelo G, Aarsland D, Vicidomini C, Longo K, Bronnick K, Amboni M, Erro R, Vitale C, Caprio MG, Pellecchia MT, Brunetti A, De Michele G, Salvatore M, Barone P
* Mild cognitive impairment in drug-naive patients with PD is associated with cerebral hypometabolism (477 views)
Neurology (ISSN: 0028-3878, 1526-632x, 1526-632xelectronic), 2011 Oct 4; 77(14): 1357-1362.
Impact Factor: 8.312
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Esmaeilzadeh M, Farde L, Karlsson P, Varrone A, Halldin C, Waters S, Tedroff J
* Extrastriatal dopamine D 2 receptor binding in Huntington's disease (462 views)
Hum Brain Mapp (ISSN: 1065-9471, 1097-0193electronic, 1065-9471linking), 2011 Oct; 32(10): 1626-1636.
Impact Factor: 5.88
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Ocak M, Helbok A, Rangger C, Peitl PK, Nock BA, Morelli G, Eek A, Sosabowskijk, Breeman WA, Reubi JC, Decristoforo C
* Comparison of biological stability and metabolism of CCK2 receptor targeting peptides, a collaborative project under COST BM0607 (692 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2011 Sep; 38(8): 1426-1435.
Impact Factor: 4.991
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Varnäs K, Nyberg S, Halldin C, Varrone A, Takano A, Karlsson P, Andersson J, McCarthy D, Smith M, Pierson ME, Söderström J, Farde L
* Quantitative analysis of [11C]AZ10419369 binding to 5-HT 1B receptors in human brain (412 views)
J Cereb Blood Flow Metab (ISSN: 0271-678x), 2011 Jan; 31(1): 113-123.
Impact Factor: 5.008
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Ciccarelli M, Sorriento D, Cipolletta E, Santulli G, Fusco A, Zhou R-H, Eckhart AD, Peppel K, Koch WJ, Trimarco B, Iaccarino G
* Impaired neoangiogenesis in β2-adrenoceptor gene-deficient mice: Restoration by intravascular human β2-adrenoceptor gene transfer and role of NFkB and CREB transcription factors (367 views)
Br J Pharmacol British Journal Of Pharmacology (ISSN: 0007-1188), 2011; 162(3): 712-721.
Impact Factor: 4.409
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Nag S, Lehmann L, Kettschau G, Thiele A, Varrone A, Gulyas B, Halldin C
* Synthesis and evaluation of [F-18]fluororasagiline, a novel PET radioligand for MAO-B (289 views)
Journal Of Labelled Compounds & Radiopharmaceuticals (ISSN: 0362-4803), 2011; 54: N/D-N/D.
Impact Factor: 1.429
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Varrone A, Halldin C
Molecular imaging of the dopamine transporter (527 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 2010 Sep 1; 51(9): 1331-1334.
Impact Factor: 7.022
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Finnema SJ, Varrone A, Hwang TJ, Gulyas B, Pierson ME, Halldin C, Farde L
* Fenfluramine-induced serotonin release decreases [11C]AZ10419369 binding to 5-HT1B-receptors in the primate brain (349 views)
Synapse (ISSN: 0887-4476), 2010 Jul; 64(7): 573-577.
Impact Factor: 2.925
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Prinster A, Quarantelli M, Lanzillo R, Orefice G, Vacca G, Carotenuto B, Alfano B, Brunetti A, Brescia Morra V, Salvatore M
* A voxel-based morphometry study of disease severity correlates in relapsing- remitting multiple sclerosis (418 views) (PDF 220 views)
Mult Scler (ISSN: 1352-4585, 1477-0970, 1352-4585linking), 2010 Jan; 16(1): 45-54.
Impact Factor: 4.23
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Varrone A, Sjoholm N, Eriksson L, Gulyas B, Halldin C, Farde L
* Advancement in PET quantification using 3D-OP-OSEM point spread function reconstruction with the HRRT (517 views) (PDF 258 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2009 Oct; 36(10): 1639-1650.
Impact Factor: 4.531
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Varrone A, Steiger C, Schou M, Takano A, Finnema SJ, Guilloteau D, Gulyas B, Halldin C
* In vitro autoradiography and in vivo evaluation in cynomolgus monkey of [18F]FE-PE2I, a new dopamine transporter PET radioligand (520 views)
Synapse (ISSN: 0887-4476), 2009 Oct; 63(10): 871-880.
Impact Factor: 2.557
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Zannetti A, Del Vecchio S, Iommelli F, Del Gatto A, De Luca S, Zaccaro L, Papaccioli A, Sommella J, Panico M, Speranza A, Grieco P, Novellino E, Saviano M, Pedone C, Salvatore M
* Imaging of αvβ3 expression by a bifunctional chimeric RGD peptide not cross-reacting with α vβ5 (860 views)
Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 2009 Sep 15; 15(16): 5224-5233.
Impact Factor: 6.747
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Takano A, Gulyas B, Varrone A, Maguire RP, Halldin C
* Saturated norepinephrine transporter occupancy by atomoxetine relevant to clinical doses: A rhesus monkey study with (S, S)-[18F]FMeNER-D (372 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2009 Sep; 36(8): 1308-1314.
Impact Factor: 4.531
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Pellecchia MT, Barone PB, Mollica C, Salvatore E, Ianniciello M, Longo K, Varrone A, Vicidomini C, Picillo M, De Michele G, Filla A, Salvatore M, Pappata S
* Diffusion-weighted imaging in multiple system atrophy: a comparison between clinical subtypes (487 views)
Mov Disord (ISSN: 1531-8257, 0885-3185, 0885-3185linking), 2009 Apr 15; 24(5): 689-696.
Impact Factor: 4.014
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Mcnab F, Varrone A, Farde L, Jucaite A, Bystritsky P, Forssberg H, Klingberg T
* Changes in cortical dopamine D1 receptor binding associated with cognitive training (359 views)
Science (ISSN: 0036-8075, 0036-8075linking), 2009 Feb 6; 323(5915): 800-802.
Impact Factor: 29.747
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Morra VB, Prinster A, Lanzillo R, Quarantelli M, Vacca G, Mollica C, Schiavone V, Brunetti A, Salvatore E, Alfano B, Orefice G
* Correlation of disease severity and regional brain tissue loss in relapsing-remitting multiple sclerosis: a voxel-based morphometry study in a large population (350 views) (PDF 220 views)
Mult Scler (ISSN: 1352-4585, 1477-0970, 1352-4585linking), 2008 Sep; 14: 45-54.
Impact Factor: 3.312
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Takano A, Halldin C, Varrone A, Karlsson P, Sjoholm N, Stubbs JB, Schou M, Airaksinen AJ, Tauscher J, Gulyas B
* Biodistribution and radiation dosimetry of the norepinephrine transporter radioligand (S, S)-[18F]FMeNER-D2: A human whole-body PET study (264 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2008 Mar; 35(3): 630-636.
Impact Factor: 4.532
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Jovanovic H, Lundberg J, Karlsson P, Cerin A, Saijo T, Varrone A, Halldin C, Nordstrom AL
* Sex differences in the serotonin 1A receptor and serotonin transporter binding in the human brain measured by PET (490 views)
Neuroimage (ISSN: 1053-8119, 1053-8119linking), 2008 Feb 1; 39(3): 1408-1419.
Impact Factor: 5.694
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Takano A, Gulyas B, Varrone A, Karlsson P, Schou M, Airaksinen AJ, Vandenhende F, Tauscher J, Halldin C
* Imaging the norepinephrine transporter with positron emission tomography: Initial human studies with (S, S)-[18F]FMeNER-D2 (304 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2008 Jan; 35(1): 153-157.
Impact Factor: 4.532
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Tedeschi G, Dinacci D, Lavorgna L, Prinster A, Savettieri G, Quattrone A, Livrea P, Messina C, Reggio A, Servillo G, Bresciamorra V, Orefice G, Paciello M, Brunetti A, Paolillo A, Coniglio G, Bonavita S, Di Costanzo A, Bellacosa A, Valentino P, Quarantelli M, Patti F, Salemi G, Cammarata E, Simone I, Salvatore M, Bonavita V, Alfano B
* Correlation between fatigue and brain atrophy and lesion load in multiple sclerosis patients independent of disability (527 views) (PDF 240 views)
J Neurol Sci (ISSN: 0022-510x), 2007 Dec 15; 263(1-2): 15-19.
Impact Factor: 2.315
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Varrone A, Pagani M, Salvatore E, Salmaso D, Sansone V, Amboni M, Nobili F, De Michele G, Filla A, Barone P, Pappata S, Salvatore M
* Identification by [Tc-99]ECD SPECT of anterior cingulate hypoperfusion in progressive supranuclear palsy, in comparison with Parkinson's disease (445 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2007 Jul; 34(7): 1071-1081.
Impact Factor: 4.101
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Landmann C, Dehaene S, Pappata S, Jobert A, Bottlaender M, Roumenov D, Le Bihan D
* Dynamics of prefrontal and cingulate activity during a reward-based logical deduction task (456 views)
Cereb Cortex (ISSN: 1047-3211), 2007 Apr; 17(4): 749-759.
Impact Factor: 6.519
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Vander Borght T, Asenbaum S, Bartenstein P, Halldin C, Kapucu O, Van Laere K, Varrone A, Tatsch K
* EANM procedure guidelines for brain tumour imaging using labelled amino acid analogues (521 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2006 Nov; 33(11): 1374-1380.
Impact Factor: 4.041
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Seneca N, Gulyas B, Varrone A, Schou M, Airaksinen A, Tauscher J, Vandenhende F, Kielbasa W, Farde L, Innis R, Halldin C
* Atomoxetine occupies the norepinephrine transporter in a dose-dependent fashion: A PET study in nonhuman primate brain using (S, S)-[18F] FMeNER-D2 (423 views)
Psychopharmacology (ISSN: 0033-3158), 2006 Sep; 188(1): 119-127.
Impact Factor: 3.625
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Berkouk K, Quarantelli M, Prinster A, Landeau B, Alfano B, Baron JC
* Mapping The Relative Contribution Of Gray Matter Activity Versus Volume In Brain Pet. A New Approach (388 views) (PDF 231 views)
J Neuroimaging (ISSN: 1051-2284, 1051-2284linking), 2006 Jul; 16(3): 224-235.
Impact Factor: 1.298
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Del Gatto A, Zaccaro L, Grieco P, Novellino E, Zannetti A, Del Vecchio S, Iommelli F, Salvatore M, Pedone C, Saviano M
* Novel And Selective Alpha (v) Beta3 Receptor Peptide Antagonist: Design, Synthesis, And Biological Behavior (618 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2006 Jun 1; 49(11): 3416-3420.
Impact Factor: 5.115
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Tedeschi G, Lavorgna L, Russo P, Prinster A, Dinacci D, Savettieri G, Quattrone A, Livrea P, Messina C, Reggio A, Bresciamorra V, Orefice G, Paciello M, Brunetti A, Coniglio G, Bonavita S, Di Costanzo A, Bellacosa A, Valentino P, Quarantelli M, Patti F, Salemi G, Cammarata E, Simone IL, Salvatore M, Bonavita V, Alfano B
* Brain atrophy and lesion load in a large population of patients with multiple sclerosis (429 views) (PDF 251 views)
Neurology (ISSN: 0028-3878, 1526-632x, 1526-632xelectronic), 2005 Jul 26; 65(2): 280-285.
Impact Factor: 5.065
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Buffon F, Molko N, Hervé D, Porcher R, Denghien I, Pappata S, Le Bihan D, Bousser MG, Chabriat H
* Longitudinal diffusion changes in cerebral hemispheres after MCA infarcts (327 views)
J Cereb Blood Flow Metab (ISSN: 0271-678x, 0271-678xlinking), 2005 May; 25(5): 641-650.
Impact Factor: 4.786
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Amato U, Larobina M, Antoniadis A, Alfano B
* Segmentation of magnetic resonance brain images through discriminant analysis (584 views) (PDF 242 views)
J Neurosci Methods (ISSN: 0165-0270, 0165-0270linking, 1872-678xelectronic), 2003 Dec 30; 131(1-2): 65-74.
Impact Factor: 1.777
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Quarantelli M, Ciarmiello A, Morra VB, Orefice G, Larobina M, Lanzillo R, Schiavone V, Salvatore E, Alfano B, Brunetti A
* Brain tissue volume changes in relapsing-remitting multiple sclerosis: Correlation with lesion load (440 views) (PDF 233 views)
Neuroimage (ISSN: 1053-8119, 1053-8119linking), 2003 Feb; 18(2): 360-366.
Impact Factor: 6.192
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Hirst WD, Abrahamsen B, Blaney FE, Calver AR, Aloj L, Price GW, Medhurst AD
* Differences In The Central Nervous System Distribution And Pharmacology Of The Mouse 5-Hydroxytryptamine-6 Receptor Compared With Rat And Human Receptors Investigated By Radioligand Binding, Site-Directed Mutagenesis, And Molecular Modeling (272 views)
Molecular Pharmacology, 2003; 64: 1295-1308.
Impact Factor: 4.12
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Pappata S, Dehaene S, Poline JB, Gregoire MC, Jobert A, Delforge J, Frouin V, Bottlaender M, Dolle F, Di Giamberardino L, Syrota A
* In Vivo detection of striatal dopamine release during reward: A PET study with [11C]raclopride and a single dynamic scan approach (374 views)
Neuroimage (ISSN: 1053-8119, 1053-8119linking), 2002 Sep; 16(4): 1015-1027.
Impact Factor: 5.624
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Zingone A, Seidel J, Aloj L, Caraco C, Vaquero JJ, Jagoda EM, Chou JY, Green MV, Eckelman WC
* Monitoring the correction of glycogen storage disease type 1a in a mouse model using [18F]FDG and a dedicated animal scanner (240 views)
Life Sci (ISSN: 0024-3205), 2002; 71(11): 1293-1301.
Impact Factor: 1.824
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Brunetti A, Tedeschi G, Di Costanzo A, Covelli EM, Aloj L, Bonavita S, Ciarmiello A, Alfano B, Salvatore M
White matter lesion detection in multiple sclerosis: Improved interobserver concordance with multispectral MRI display (316 views) (PDF 290 views)
J Neurol (ISSN: 0340-5354, 1432-1459, 1432-1459electronic), 1997 Sep; 244(9): 586-590.
Impact Factor: 1.976
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Wang H, Maurea S, Mainolfi C, Fiore F, Gravina A, Panico M, Bazzicalupo L, Salvatore M
Tc-99m MIBI scintigraphy in patients with lung cancer comparison with CT and fluorine-18 FDG PET imaging (302 views)
Clin Nucl Med (ISSN: 0363-9762, 1536-0229, 1536-0229electronic), 1997 Apr; 22(4): 243-249.
Impact Factor: 0.34
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Alfano B, Brunetti A
Advances in brain imaging: A new ethical challenge (288 views) (PDF 390 views)
Ann Ist Super Sanita (ISSN: 0021-2571), 1997; 33(4): 483-488.
Impact Factor: 0.343
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52 Records (49 excluding Abstracts).
Total impact factor: 242.932 (235.561 excluding Abstracts).
Total 5 year impact factor: 254.646 (247.279 excluding Abstracts).
Total impact factor: 242.932 (235.561 excluding Abstracts).
Total 5 year impact factor: 254.646 (247.279 excluding Abstracts).
292 views. Last view on Saturday 14 January 2023, 19:18:16
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