Mapping of the norepinephrine transporter in man using PET with (S, S)-[F-18]FMeNER-D-2(292 views)(PDF restricted204 views) Takano A, Varrone A, Gulyas B, Karlsson P, Tauscher J, Halldin C
Keywords: Fluorine 18, Noradrenalin Transporter, Radioligand, Adult, Article, Brain Aqueduct, Brain Mapping, Brain Stem, Calculation, Clinical Article, Computer Program, Controlled Study, Human, Human Experiment, In Vivo Study, Locus Ceruleus, Mesencephalon, Normal Human, Nuclear Magnetic Resonance Imaging, Positron Emission Tomography, Priority Journal, Pulvinar, Receptor Binding, Thalamus, Validity, Morpholines, Norepinephrine Plasma Membrane Transport Proteins, Positron-Emission Tomography, Radiopharmaceuticals, Tissue Distribution,
Affiliations: *** IBB - CNR ***
Karolinska Institutet, Department of Clinical Neuroscience, Psychiatry Section, Stockholm, Sweden
Eli-Lilly and Company, Indianapolis, IN, United States
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Cannon, D. M., Ichise, M., Fromm, S. J., Nugent, A. C., Rollis, D., Gandhi, S. K., Klaver, J. M., Drevets, W. C., Serotonin transporter binding in bipolar disorder assessed using [11C] DASB and positron emission tomography (2006) Biol. Psychiatry, 60, pp. 207-217
Foote, S. L., Bloom, F. E., Aston-Jones, G., Nucleus locus ceruleus: new evidence of anatomical and physiological specificity (1983) Physiol. Rev., 63, pp. 844-914
Heneka, M. T., Ramanathan, M., Jacobs, A. H., Dumitrescu-Ozimek, L., Bilkei-Gorzo, A., Debeir, T., Sastre, M., Staufenbiel, M., Locus ceruleus degeneration promotes Alzheimer pathogenesis in amyloid precursor protein 23 transgenic mice (2006) J. Neurosci., 26, pp. 1343-1354
Innis, R. B., Cunningham, V. J., Delforge, J., Fujita, M., Gjedde, A., Gunn, R. N., Holden, J., Carson, R. E., Consensus nomenclature for in vivo imaging of reversibly binding radioligands (2007) J. Cereb. Blood Flow Metab., 27, pp. 1533-1539
Javitch, J. A., Strittmatter, S. M., Snyder, S. H., Differential visualization of dopamine and norepinephrine uptake sites in rat brain using [3H] mazindol autoradiography (1985) J. Neurosci., 5, pp. 1513-1521
Jensen, S. B., Olsen, A. K., Pedersen, K., Cumming, P., Effect of monoamine oxidase inhibition on amphetamine-evoked changes in dopamine receptor availability in the living pig: a dual tracer PET study with [11C] harmine and [11C] raclopride (2006) Synapse, 59, pp. 427-434
Marner, L., S borg, C., Pakkenberg, B., Increased volume of the pigmented neurons in the locus coeruleus of schizophrenic subjects: a stereological study (2005) J. Psychiatr. Res., 39, pp. 337-345
Mash, D. C., Ouyang, Q., Qin, Y., Pablo, J., Norepinephrine transporter immunoblotting and radioligand binding in cocaine abusers (2005) J. Neurosci. Methods, 143, pp. 79-85
Mesulam, M. M., Mufson, E. J., Insula of the old world monkey. I. Architectonics in the insulo-orbito-temporal component of the paralimbic brain (1982) J. Comp. Neurol., 212, pp. 1-22
Oke, A. F., Carver, L. A., Gouvion, C. M., Adams, R. N., Three-dimensional mapping of norepinephrine and serotonin in human thalamus (1997) Brain Res., 763, pp. 69-78
Ordway, G. A., Stockmeier, C. A., Cason, G. W., Klimek, V., Pharmacology and distribution of norepinephrine transporters in the human locus coeruleus and raphe nuclei (1997) J. Neurosci., 17, pp. 1710-1719
Schulz, J. B., Skalej, M., Wedekind, D., Luft, A. R., Abele, M., Voigt, K., Dichgans, J., Klockgether, T., Magnetic resonance imaging-based volumetry differentiates idiopathic Parkinson's syndrome from multiple system atrophy and progressive supranuclear palsy (1999) Ann. Neurol., 45, pp. 65-74
Seneca, N., Guly s, B., Varrone, A., Schou, M., Airaksinen, A., Tauscher, J., Vandenhende, F., Halldin, C., Atomoxetine occupies the norepinephrine transporter in a dose-dependent fashion: a PET study in nonhuman primate brain using (S, S) - [18F] FMeNER-D2 (2006) Psychopharmacology (Berl.), 188, pp. 119-127
Smith, H. R., Beveridge, T. J., Porrino, L. J., Distribution of norepinephrine transporters in the non-human primate brain (2006) Neuroscience, 138, pp. 703-714
Swanson, L. W., Hartman, B. K., The central adrenergic system. An immunofluorescence study of the location of cell bodies and their efferent connections in the rat utilizing dopamine-beta-hydroxylase as a marker (1975) J. Comp. Neurol., 163, pp. 467-505
Szab, C. A., Lancaster, J. L., Xiong, J., Cook, C., Fox, P., MR imaging volumetry of subcortical structures and cerebellar hemispheres in normal persons (2003) A. J. N. R. Am. J. Neuroradiol., 24, pp. 644-647
Takano, A., Guly s, B., Varrone, A., Karlsson, P., Schou, M., Airaksinen, A. J., Vandenhende, F., Halldin, C., Imaging the norepinephrine transporter with positron emission tomography: initial human studies with (S, S) - [18F] FMeNER-D2 (2008) Eur. J. Nucl. Med. Mol. Imaging, 35, pp. 153-157
Tejani-Butt, S. M., [3H] nisoxetine: a radioligand for quantitation of norepinephrine uptake sites by autoradiography or by homogenate binding (1992) J. Pharmacol. Exp. Ther., 260, pp. 427-436
Mapping of the norepinephrine transporter in man using PET with (S, S)-[F-18]FMeNER-D-2
We have evaluated the detailed mapping of the norepinephrine transporter (NET) in the human brain with (S, S)-[(18)F]FMeNER-D(2) using a template method and the generation of functional ROIs based on the PET information. Brain PET measurements were performed from 90 to 210 min after the injection of (S,S)-[(18)F] FMeNER-D2 in 20 healthy male Subjects. Binding potential (BP(ND)) was calculated as late time ratio of the target region to the reference region (caudate) minus one. BP(ND) template images were generated from mean parametric images obtained in a group of 10 Subjects Using SPM2. On the BP(ND)/MRI template images, functional ROIs based on several different BP(ND) thresholds for the thalamus and brainstem were generated automatically using PMOD 2.8 software in addition to anatomical ROIs. PET/MRI data of another group Of 10 subjects were used to evaluate the validity of the template method and the functional ROIs. NET BPND template images demonstrated higher binding in the media[ thalamus whereas the anterior and the pulvinar divisions had lower binding. In the brainstem, high binding was detected around the cerebral aqueduct of the midbrain and within the dorsal pons, in a volume comprising locus coeruleus. Functional ROIs with higher BP(ND) thresholds naturally yielded higher BPND and lower coefficients of variance than did anatomical ROIs. This study indicated that (S,S)-[(18)F]FMeNER-D(2) combined with a template method provides detailed information on the distribution of NET in vivo and that functional ROIs on the template would be useful in further clinical studies. (C) 2008 Elsevier Inc. All rights reserved.
Mapping of the norepinephrine transporter in man using PET with (S, S)-[F-18]FMeNER-D-2
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Mapping of the norepinephrine transporter in man using PET with (S, S)-[F-18]FMeNER-D-2