Micelles by self-assembling peptide-conjugate amphiphile: Synthesis and structural characterization (410 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2008 Sep; 14(8): 903-910.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 1.654, 5-year impact factor: 1.782
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-50449109791&partnerID=40&md5=95ed4874c34e00526c96795f76a72228
Keywords: Cck8 Peptide, Micelles, Peptide-Conjugate Amphiphile (pca), Small-Angle Neutron Scattering, Amphophile, Carbon, Chelating Agent, Cholecystokinin Octapeptide, Pentetic Acid Derivative, Water, Article, Chemical Structure, Concentration (parameters), Contrast Enhancement, Controlled Study, Fluorescence Analysis, Fluorescence Spectroscopy, Hydrophobicity, Nuclear Magnetic Resonance Imaging, Priority Journal, Protein Assembly, Synthesis, Molecular Structure, Neutron Diffraction, Peptide Fragments, Small Angle, Sincalide, Solutions, Spectrometry, Surface-Active Agents,
Affiliations:
*** IBB - CNR ***
Department of Biological Sciences, CIRPeB University of Naples 'Federico II', IBB CNR, Via Mezzocannone 16, 80134 Naples, Italy
Department of Chemistry, University of Naples 'Federico II', Via Cinthia, 80126 Naples, Italy
References:
Bull, S.R., Guler, M.O., Bras, R.E., Meade, T.J., Stupp, S.I., Self-assembled peptide amphiphile nanofibers conjugated to MRI contrast agents (2005) Nano Lett, 5, pp. 1-
Brandwijk, R.J., Mulder, W.J.M., Nicolay, K., Mayo, R.H., Thijssen, V.L.J., Griffioen, A.W., Anginex-conjugated liposomes for targeting of angiogenic endothelial cells (2007) Bioconjugate Chem, 18, pp. 785-790
Li King, C.P., Bednarski, M.D., Vascular-targeted molecular imaging using functionalized polymerized vesicles (2002) J. Magn. Imaging, 16, pp. 388-393
Mulder, W.J.M., Strijkers, G.J., Griffioen, A.W., Van Bloois, L., Molema, G., Storm, G., Koning, A., Nicolay, K., A liposomal system for contrast-enhanced magnetic resonance imaging of molecular targets (2004) Bioconjugate Chem, 15, pp. 799-806
Ferrari, M., Cancer nanotechnology: Opportunities and challenges (2005) Nat. Rev. Cancer, 5, pp. 161-171
Accardo, A., Tesauro, D., Roscigno, P., Gianolio, E., Paduano, L., D'Errico, G., Pedone, C., Morelli, G., Physicochemical properties of mixed micellar aggregates containing CCK peptides and Gd complexes designed as tumor specffic contrast agents in MRI (2004) J. Am. Chem. Soc, 126, pp. 3097-3107
Vaccaro, M., Mangiapia, G., Paduano, L., Gianolio, E., Accardo, A., Tesauro, D., Morelli, G., Structural and relaxometric Characterization peptide aggregates containing gadolinium complexes as potential selective contrast agents in MRI (2007) ChemPhysChem, 8, pp. 2526-2538
Israelachvilli, J.N., Mitchell, D.J., Ninham, B.W., Theory of self-assembly of hydrocarbon amphiphiles into micelles and bilayers (1976) J. Chem. Soc., Faraday Trans. 2: Mol. Chem. Phys, 72, pp. 1525-1568
Chang, W.C., White, P.D., (2000) Fmoc Solid Phase Peptide Synthesis, , Oxford University Press: Oxford, UK
Chhabra, S.R., Parekh, H., Khan, A.N., Bycroft, B.W., Kellam, B., A Dde-based carboxy linker for solid-phase synthesis (2001) Tetrahedron Lett, 42, pp. 2189-2192
Shinoda, K., Tamamushi, B., Nakagawa, T., Isemura, T., (1963) Colloidal Surfactants, , Academic Press: New York
Rohatgi-Mukherjee, K.K., Chaudhuri, R., Bhowmik, B.B., Molecular interaction of phenosafranin with surfactants and its photogalvanic effect (1985) J. Colloid Interface Sci, 106, pp. 45-50
Ray, P., Bhattacharya, S.C., Moulik, S.P., Role of Brij micelles in the quenching of fluorescence of Safranine T by inorganic ions (1998) J. Photochem. Photobiol., A: Chem, 116, pp. 85-89
Lackowicz, J.R., (1983) Principles of Fluorescence Spectroscopy, , Plenum Press: New York
Jones, G., Lu, L.N., Vullev, V., Gosztola, D.J., Greenfield, S.R., Wasielewski, M.R., Photoactive peptides. 6. Photoinduced electron transfer for pyrenesulfonamide conjugates of tryptophan-containing peptides. Mitigation of fluoroprobe behavior in N-terminal labeling experiments (1995) Bioorg. Med. Chem. Lett, 5, pp. 2385-2390
Moore, S.A., Harris, A.A., Palepu, R.M., Spectroscopic investigations on the binding of ammonium salt of 8-anilino-1-naphthalene sulfonic acid with non-ionic surfactant micelles in aqueous media (2007) Fluid Phase Equilib, 251, pp. 110-113
Permyakov, E.A., (1993) Luminescent Spectroscopy of Proteins, , CRC Press: Boca Raton, FL
Kotlarchyk, M., Chen, S.H., Analysis of small angle neutron scattering spectra from polydisperse interacting colloids (1983) J. Chem. Phys, 79, pp. 2461-2469
Feigin, L.A., Svergun, D.I., (1987) Structure Analysis by Small-Angle X-Ray and Neutron Scattering, , Plenum Press: New York, USA
Anelli, P.L., Fedeli, F., Gazzotti, O., Lattuada, L., Lux, G., Rebasti, F., L-glutamic acid and L-lysine as useful building blocks for the preparation of bifunctional DTPA-like ligands (1999) Bioconjugate Chem, 10, pp. 137-140
Schmitt, L., Dietrich, C., Synthesis and characterization of chelator-lipids for reversible immobilization of engineered proteins at self-assembled lipid interfaces (1994) J. Am. Chem. Soc, 116, pp. 8485-8491
Edelhoch, H., Spectroscopic determination of tryptophan and tyrosine in proteins (1967) Biochemistry, 6, pp. 1948-1954
Pace, C.N., Vajdos, F., Fee, L., Grimsley, G., Gray, T., How to measure and predict the molar absorption coefficient of a protein (1995) Protein Sci, 4, pp. 2411-2423
Birdi, K.S., Singh, H.N., Dalsager, S.U., Interaction of ionic micelles with the hydrophobic fluorescent probe 1-anilino-8-naphthalene-sulfonate (1979) J. Phys. Chem, 83, pp. 2733-2737
De Vendittis, E., Palumbo, G., Parlato, G., Bocchini, V., A fluorimetric method for the estimation of the critical micelle concentration of surfactants (1981) Anal. Biochem, 115, pp. 278-286
Heenan, R.K., Penfold, J., King, S.M., SANS at pulsed neutron sources: Present and future prospects (1997) J. Appl. Crystallogr, 30, p. 1140
Bull, S. R., Guler, M. O., Bras, R. E., Meade, T. J., Stupp, S. I., Self-assembled peptide amphiphile nanofibers conjugated to MRI contrast agents (2005) Nano Lett, 5, pp. 1-
Brandwijk, R. J., Mulder, W. J. M., Nicolay, K., Mayo, R. H., Thijssen, V. L. J., Griffioen, A. W., Anginex-conjugated liposomes for targeting of angiogenic endothelial cells (2007) Bioconjugate Chem, 18, pp. 785-790
Li King, C. P., Bednarski, M. D., Vascular-targeted molecular imaging using functionalized polymerized vesicles (2002) J. Magn. Imaging, 16, pp. 388-393
Mulder, W. J. M., Strijkers, G. J., Griffioen, A. W., Van Bloois, L., Molema, G., Storm, G., Koning, A., Nicolay, K., A liposomal system for contrast-enhanced magnetic resonance imaging of molecular targets (2004) Bioconjugate Chem, 15, pp. 799-806
Israelachvilli, J. N., Mitchell, D. J., Ninham, B. W., Theory of self-assembly of hydrocarbon amphiphiles into micelles and bilayers (1976) J. Chem. Soc., Faraday Trans. 2: Mol. Chem. Phys, 72, pp. 1525-1568
Chang, W. C., White, P. D., (2000) Fmoc Solid Phase Peptide Synthesis, , Oxford University Press: Oxford, UK
Chhabra, S. R., Parekh, H., Khan, A. N., Bycroft, B. W., Kellam, B., A Dde-based carboxy linker for solid-phase synthesis (2001) Tetrahedron Lett, 42, pp. 2189-2192
Lackowicz, J. R., (1983) Principles of Fluorescence Spectroscopy, , Plenum Press: New York
Jones, G., Lu, L. N., Vullev, V., Gosztola, D. J., Greenfield, S. R., Wasielewski, M. R., Photoactive peptides. 6. Photoinduced electron transfer for pyrenesulfonamide conjugates of tryptophan-containing peptides. Mitigation of fluoroprobe behavior in N-terminal labeling experiments (1995) Bioorg. Med. Chem. Lett, 5, pp. 2385-2390
Moore, S. A., Harris, A. A., Palepu, R. M., Spectroscopic investigations on the binding of ammonium salt of 8-anilino-1-naphthalene sulfonic acid with non-ionic surfactant micelles in aqueous media (2007) Fluid Phase Equilib, 251, pp. 110-113
Permyakov, E. A., (1993) Luminescent Spectroscopy of Proteins, , CRC Press: Boca Raton, FL
Feigin, L. A., Svergun, D. I., (1987) Structure Analysis by Small-Angle X-Ray and Neutron Scattering, , Plenum Press: New York, USA
Anelli, P. L., Fedeli, F., Gazzotti, O., Lattuada, L., Lux, G., Rebasti, F., L-glutamic acid and L-lysine as useful building blocks for the preparation of bifunctional DTPA-like ligands (1999) Bioconjugate Chem, 10, pp. 137-140
Pace, C. N., Vajdos, F., Fee, L., Grimsley, G., Gray, T., How to measure and predict the molar absorption coefficient of a protein (1995) Protein Sci, 4, pp. 2411-2423
Birdi, K. S., Singh, H. N., Dalsager, S. U., Interaction of ionic micelles with the hydrophobic fluorescent probe 1-anilino-8-naphthalene-sulfonate (1979) J. Phys. Chem, 83, pp. 2733-2737
Heenan, R. K., Penfold, J., King, S. M., SANS at pulsed neutron sources: Present and future prospects (1997) J. Appl. Crystallogr, 30, p. 1140
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2008 Sep; 14(8): 903-910.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 1.654, 5-year impact factor: 1.782
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-50449109791&partnerID=40&md5=95ed4874c34e00526c96795f76a72228
Keywords: Cck8 Peptide, Micelles, Peptide-Conjugate Amphiphile (pca), Small-Angle Neutron Scattering, Amphophile, Carbon, Chelating Agent, Cholecystokinin Octapeptide, Pentetic Acid Derivative, Water, Article, Chemical Structure, Concentration (parameters), Contrast Enhancement, Controlled Study, Fluorescence Analysis, Fluorescence Spectroscopy, Hydrophobicity, Nuclear Magnetic Resonance Imaging, Priority Journal, Protein Assembly, Synthesis, Molecular Structure, Neutron Diffraction, Peptide Fragments, Small Angle, Sincalide, Solutions, Spectrometry, Surface-Active Agents,
Affiliations:
*** IBB - CNR ***
Department of Biological Sciences, CIRPeB University of Naples 'Federico II', IBB CNR, Via Mezzocannone 16, 80134 Naples, Italy
Department of Chemistry, University of Naples 'Federico II', Via Cinthia, 80126 Naples, Italy
References:
Bull, S.R., Guler, M.O., Bras, R.E., Meade, T.J., Stupp, S.I., Self-assembled peptide amphiphile nanofibers conjugated to MRI contrast agents (2005) Nano Lett, 5, pp. 1-
Brandwijk, R.J., Mulder, W.J.M., Nicolay, K., Mayo, R.H., Thijssen, V.L.J., Griffioen, A.W., Anginex-conjugated liposomes for targeting of angiogenic endothelial cells (2007) Bioconjugate Chem, 18, pp. 785-790
Li King, C.P., Bednarski, M.D., Vascular-targeted molecular imaging using functionalized polymerized vesicles (2002) J. Magn. Imaging, 16, pp. 388-393
Mulder, W.J.M., Strijkers, G.J., Griffioen, A.W., Van Bloois, L., Molema, G., Storm, G., Koning, A., Nicolay, K., A liposomal system for contrast-enhanced magnetic resonance imaging of molecular targets (2004) Bioconjugate Chem, 15, pp. 799-806
Ferrari, M., Cancer nanotechnology: Opportunities and challenges (2005) Nat. Rev. Cancer, 5, pp. 161-171
Accardo, A., Tesauro, D., Roscigno, P., Gianolio, E., Paduano, L., D'Errico, G., Pedone, C., Morelli, G., Physicochemical properties of mixed micellar aggregates containing CCK peptides and Gd complexes designed as tumor specffic contrast agents in MRI (2004) J. Am. Chem. Soc, 126, pp. 3097-3107
Vaccaro, M., Mangiapia, G., Paduano, L., Gianolio, E., Accardo, A., Tesauro, D., Morelli, G., Structural and relaxometric Characterization peptide aggregates containing gadolinium complexes as potential selective contrast agents in MRI (2007) ChemPhysChem, 8, pp. 2526-2538
Israelachvilli, J.N., Mitchell, D.J., Ninham, B.W., Theory of self-assembly of hydrocarbon amphiphiles into micelles and bilayers (1976) J. Chem. Soc., Faraday Trans. 2: Mol. Chem. Phys, 72, pp. 1525-1568
Chang, W.C., White, P.D., (2000) Fmoc Solid Phase Peptide Synthesis, , Oxford University Press: Oxford, UK
Chhabra, S.R., Parekh, H., Khan, A.N., Bycroft, B.W., Kellam, B., A Dde-based carboxy linker for solid-phase synthesis (2001) Tetrahedron Lett, 42, pp. 2189-2192
Shinoda, K., Tamamushi, B., Nakagawa, T., Isemura, T., (1963) Colloidal Surfactants, , Academic Press: New York
Rohatgi-Mukherjee, K.K., Chaudhuri, R., Bhowmik, B.B., Molecular interaction of phenosafranin with surfactants and its photogalvanic effect (1985) J. Colloid Interface Sci, 106, pp. 45-50
Ray, P., Bhattacharya, S.C., Moulik, S.P., Role of Brij micelles in the quenching of fluorescence of Safranine T by inorganic ions (1998) J. Photochem. Photobiol., A: Chem, 116, pp. 85-89
Lackowicz, J.R., (1983) Principles of Fluorescence Spectroscopy, , Plenum Press: New York
Jones, G., Lu, L.N., Vullev, V., Gosztola, D.J., Greenfield, S.R., Wasielewski, M.R., Photoactive peptides. 6. Photoinduced electron transfer for pyrenesulfonamide conjugates of tryptophan-containing peptides. Mitigation of fluoroprobe behavior in N-terminal labeling experiments (1995) Bioorg. Med. Chem. Lett, 5, pp. 2385-2390
Moore, S.A., Harris, A.A., Palepu, R.M., Spectroscopic investigations on the binding of ammonium salt of 8-anilino-1-naphthalene sulfonic acid with non-ionic surfactant micelles in aqueous media (2007) Fluid Phase Equilib, 251, pp. 110-113
Permyakov, E.A., (1993) Luminescent Spectroscopy of Proteins, , CRC Press: Boca Raton, FL
Kotlarchyk, M., Chen, S.H., Analysis of small angle neutron scattering spectra from polydisperse interacting colloids (1983) J. Chem. Phys, 79, pp. 2461-2469
Feigin, L.A., Svergun, D.I., (1987) Structure Analysis by Small-Angle X-Ray and Neutron Scattering, , Plenum Press: New York, USA
Anelli, P.L., Fedeli, F., Gazzotti, O., Lattuada, L., Lux, G., Rebasti, F., L-glutamic acid and L-lysine as useful building blocks for the preparation of bifunctional DTPA-like ligands (1999) Bioconjugate Chem, 10, pp. 137-140
Schmitt, L., Dietrich, C., Synthesis and characterization of chelator-lipids for reversible immobilization of engineered proteins at self-assembled lipid interfaces (1994) J. Am. Chem. Soc, 116, pp. 8485-8491
Edelhoch, H., Spectroscopic determination of tryptophan and tyrosine in proteins (1967) Biochemistry, 6, pp. 1948-1954
Pace, C.N., Vajdos, F., Fee, L., Grimsley, G., Gray, T., How to measure and predict the molar absorption coefficient of a protein (1995) Protein Sci, 4, pp. 2411-2423
Birdi, K.S., Singh, H.N., Dalsager, S.U., Interaction of ionic micelles with the hydrophobic fluorescent probe 1-anilino-8-naphthalene-sulfonate (1979) J. Phys. Chem, 83, pp. 2733-2737
De Vendittis, E., Palumbo, G., Parlato, G., Bocchini, V., A fluorimetric method for the estimation of the critical micelle concentration of surfactants (1981) Anal. Biochem, 115, pp. 278-286
Heenan, R.K., Penfold, J., King, S.M., SANS at pulsed neutron sources: Present and future prospects (1997) J. Appl. Crystallogr, 30, p. 1140
Bull, S. R., Guler, M. O., Bras, R. E., Meade, T. J., Stupp, S. I., Self-assembled peptide amphiphile nanofibers conjugated to MRI contrast agents (2005) Nano Lett, 5, pp. 1-
Brandwijk, R. J., Mulder, W. J. M., Nicolay, K., Mayo, R. H., Thijssen, V. L. J., Griffioen, A. W., Anginex-conjugated liposomes for targeting of angiogenic endothelial cells (2007) Bioconjugate Chem, 18, pp. 785-790
Li King, C. P., Bednarski, M. D., Vascular-targeted molecular imaging using functionalized polymerized vesicles (2002) J. Magn. Imaging, 16, pp. 388-393
Mulder, W. J. M., Strijkers, G. J., Griffioen, A. W., Van Bloois, L., Molema, G., Storm, G., Koning, A., Nicolay, K., A liposomal system for contrast-enhanced magnetic resonance imaging of molecular targets (2004) Bioconjugate Chem, 15, pp. 799-806
Israelachvilli, J. N., Mitchell, D. J., Ninham, B. W., Theory of self-assembly of hydrocarbon amphiphiles into micelles and bilayers (1976) J. Chem. Soc., Faraday Trans. 2: Mol. Chem. Phys, 72, pp. 1525-1568
Chang, W. C., White, P. D., (2000) Fmoc Solid Phase Peptide Synthesis, , Oxford University Press: Oxford, UK
Chhabra, S. R., Parekh, H., Khan, A. N., Bycroft, B. W., Kellam, B., A Dde-based carboxy linker for solid-phase synthesis (2001) Tetrahedron Lett, 42, pp. 2189-2192
Lackowicz, J. R., (1983) Principles of Fluorescence Spectroscopy, , Plenum Press: New York
Jones, G., Lu, L. N., Vullev, V., Gosztola, D. J., Greenfield, S. R., Wasielewski, M. R., Photoactive peptides. 6. Photoinduced electron transfer for pyrenesulfonamide conjugates of tryptophan-containing peptides. Mitigation of fluoroprobe behavior in N-terminal labeling experiments (1995) Bioorg. Med. Chem. Lett, 5, pp. 2385-2390
Moore, S. A., Harris, A. A., Palepu, R. M., Spectroscopic investigations on the binding of ammonium salt of 8-anilino-1-naphthalene sulfonic acid with non-ionic surfactant micelles in aqueous media (2007) Fluid Phase Equilib, 251, pp. 110-113
Permyakov, E. A., (1993) Luminescent Spectroscopy of Proteins, , CRC Press: Boca Raton, FL
Feigin, L. A., Svergun, D. I., (1987) Structure Analysis by Small-Angle X-Ray and Neutron Scattering, , Plenum Press: New York, USA
Anelli, P. L., Fedeli, F., Gazzotti, O., Lattuada, L., Lux, G., Rebasti, F., L-glutamic acid and L-lysine as useful building blocks for the preparation of bifunctional DTPA-like ligands (1999) Bioconjugate Chem, 10, pp. 137-140
Pace, C. N., Vajdos, F., Fee, L., Grimsley, G., Gray, T., How to measure and predict the molar absorption coefficient of a protein (1995) Protein Sci, 4, pp. 2411-2423
Birdi, K. S., Singh, H. N., Dalsager, S. U., Interaction of ionic micelles with the hydrophobic fluorescent probe 1-anilino-8-naphthalene-sulfonate (1979) J. Phys. Chem, 83, pp. 2733-2737
Heenan, R. K., Penfold, J., King, S. M., SANS at pulsed neutron sources: Present and future prospects (1997) J. Appl. Crystallogr, 30, p. 1140
Micelles by self-assembling peptide-conjugate amphiphile: Synthesis and structural characterization
The chemical synthesis by solid-phase methods of a novel amphiphilic peptide, peptide-conjugate amphiphile (PCA), containing in the same molecule three different functions: (i) the N,N-bis[2-[bis(carboxy-ethyl)aminolethyl]-L-glutamic acid (DTPAGlu) chelating agent, (ii) the CCK8 bioactive peptide, and (iii) a hydrophobic moiety containing four alkyl chains with 18 carbon atoms each, is reported. In water solution at pH 7.4, PCA self-assembles in very stable micelles at very low concentration [critical micellar concentration (cmc) values of 5 × 10-7 mol kg-1] as confirmed by fluorescence spectroscopy. The structural characterization, obtained with small-angle neutron scattering (SANS) measurements, indicates that the aggregates are substantially represented by ellipsoidal micelles with an aggregation number of 39 ± 2 and the two micellar axes of about 52 and 26 Å. Copyright © 2008 European Peptide Society and John Wiley & Sons, Ltd.
The chemical synthesis by solid-phase methods of a novel amphiphilic peptide, peptide-conjugate amphiphile (PCA), containing in the same molecule three different functions: (i) the N,N-bis[2-[bis(carboxy-ethyl)aminolethyl]-L-glutamic acid (DTPAGlu) chelating agent, (ii) the CCK8 bioactive peptide, and (iii) a hydrophobic moiety containing four alkyl chains with 18 carbon atoms each, is reported. In water solution at pH 7.4, PCA self-assembles in very stable micelles at very low concentration [critical micellar concentration (cmc) values of 5 × 10-7 mol kg-1] as confirmed by fluorescence spectroscopy. The structural characterization, obtained with small-angle neutron scattering (SANS) measurements, indicates that the aggregates are substantially represented by ellipsoidal micelles with an aggregation number of 39 ± 2 and the two micellar axes of about 52 and 26 Å. Copyright © 2008 European Peptide Society and John Wiley & Sons, Ltd.
Micelles by self-assembling peptide-conjugate amphiphile: Synthesis and structural characterization
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Micelles by self-assembling peptide-conjugate amphiphile: Synthesis and structural characterization
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Impact Factor: 3.825
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Arnesano F, Scintilla S, Calò V, Bonfrate E, Ingrosso C, Losacco M, Pellegrino T, Rizzarelli E, Natile G
* Copper-triggered aggregation of ubiquitin (534 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2009 Sep 16; 4(9): e7052-e7052.
Impact Factor: 4.351
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Accardo A, Tesauro D, Morisco A, Mangiapia G, Vaccaro M, Gianolio E, Heenan RK, Paduano L, Morelli G
* Micelles obtained by aggregation of gemini surfactants containing the CCK8 peptide and a gadolinium complex (398 views)
J Biol Inorg Chem (ISSN: 0949-8257, 1432-1327electronic, 0949-8257linking), 2009 May; 14(4): 587-599.
Impact Factor: 3.415
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Ciaccio C, Tundo GR, Grasso G, Spoto G, Marasco D, Ruvo M, Gioia M, Rizzarelli E, Coletta M
* Somatostatin: a novel substrate and a modulator of insulin-degrading enzyme activity (455 views)
J Mol Biol (ISSN: 1089-8638, 0022-2836, 1089-8638electronic), 2009 Feb 6; 385(5): 1556-1567.
Impact Factor: 3.871
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Accardo A, Tesauro D, Morelli G, Del Pozzo L, Pedone C, Tornesello AL, Benedetti E
* Supramolecular aggregates derivatized by CCK8 peptide as selective nanocarriers for drug delivery (362 views)
Adv Exp Med Biol (ISSN: 0065-2598, 0065-2598print), 2009; 611: 603-604.
Impact Factor: 2.02
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Vaccaro M, Mangiapia G, Accardo A, Tesauro D, Gianolio E, Frielinghaus H, Morelli G, Paduano L
* Polymerized mixed aggregates containing gadolinium complex and CCK8 peptide (429 views)
Colloid Polym Sci (ISSN: 0303-402x), 2008 Dec; 286(14-15): 1643-1652.
Impact Factor: 1.736
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Accardo A, Tesauro D, Aloj L, Tarallo L, Arra C, Mangiapia G, Vaccaro M, Pedone C, Paduano L, Morelli G
* Peptide-containing aggregates as selective nanocarriers for therapeutics (392 views)
Chemmedchem (ISSN: 1860-7179, 1860-7187, 1860-7187electronic), 2008 Apr; 3(4): 594-602.
Impact Factor: 3.15
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D'Andrea LD, Testa I, Panico M, Di Stasi R, Carac C, Tarallo L, Arra C, Barbieri A, Romanelli A, Aloj L
* In vivo and in vitro characterization of CCK8 bearing a histidine-based chelator labeled with Tc-99m-tricarbonyl (424 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2008; 90(5): 707-712.
Impact Factor: 2.823
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Vaccaro M, Accardo A, D'Errico G, Schillen K, Radulescu A, Tesauro D, Morelli G, Paduano L
* Peptides and gd complexes containing colloidal assemblies as tumor-specific contrast agents in MRI: Physicochemical characterization (399 views)
Biophysical Journal (ISSN: 0006-3495, 1542-0086), 2007 Sep; 93(5): 1736-1746.
Impact Factor: 4.627
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Cuzzocrea S, Genovese T, Failla M, Vecchio G, Fruciano M, Mazzon E, Di Paola R, Muià C, La Rosa C, Crimi N, Rizzarelli E, Vancheri C
* Protective effect of orally administered carnosine on bleomycin-induced lung injury (721 views)
Am J Physiol Lung Cell Mol Physiol (ISSN: 1040-0605), 2007 May; 292(5): L1095-L1095.
Impact Factor: 4.214
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Agostini S, Bolzati C, Didonè E, Cavazza-Ceccato M, Refosco F, Aloj L, Arra C, Aurilio M, Tornesello AL, Tesauro D, Morelli G
* The (Tc(N)(PNP))2+ metal fragment labeled cholecystokinin-8 (CCK8) peptide for CCK-2 receptors imaging: In vitro and in vivo studies (410 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2007 Apr; 13(4): 211-219.
Impact Factor: 1.768
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Accardo A, Tesauro D, Morelli G, Gianolio E, Aime S, Vaccaro M, Mangiapia G, Paduano L, Schillén K
* High-relaxivity supramolecular aggregates containing peptides and Gd complexes as contrast agents in MRI (433 views)
J Biol Inorg Chem (ISSN: 0949-8257, 1432-1327electronic, 0949-8257print), 2007 Feb; 12(2): 267-276.
Impact Factor: 3.325
View Export to BibTeX Export to EndNote
Accardo A, Tesauro D, Mangiapia G, Pedone C, Morelli G
* Nanostructures by self-assembling peptide amphiphile as potential selective drug carriers (438 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2007; 88(2): 115-121.
Impact Factor: 2.389
View Export to BibTeX Export to EndNote
De Luca S, Sanseverino M, Zocchi I, Pedone C, Morelli G, Ragone R
* Receptor fragment approach to the binding between CCK8 peptide and cholecystokinin receptors: A fluorescence study on type B receptor fragment CCKB-R (352-379) (371 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2005 Mar; 77(4): 205-211.
Impact Factor: 2.545
View Export to BibTeX Export to EndNote
De Luca S, Morelli G
* Synthesis and characterization of a sulfated and a non-sulfated cyclic CCK8 analogue functionalized with a chelating group for metal labelling (395 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2004 May; 10(5): 265-273.
Impact Factor: 1.652
View Export to BibTeX Export to EndNote
Mansi R, Tesauro D, De Capua A, Fattorusso R, Carac C, Aloj L, Benedetti E, Morelli G
* Peptide-chelating agent conjugate for selective targeting of somatostatin receptor type 1: Synthesis and characterization (472 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2004; 76(6): 527-534.
Impact Factor: 2.863
View Export to BibTeX Export to EndNote
Morelli G, De Luca S, Tesauro D, Saviano M, Pedone C, Dolmella A, Visentin R, Mazzi U
* CCK8 peptide derivatized with diphenylphosphine for rhenium labelling: Synthesis and molecular mechanics calculations (325 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2002 Jul; 8(7): 373-381.
Impact Factor: 1.691
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Aloj L, Zannetti A, Caraco C, Del Vecchio S, Tasauro D, De Luca S, Brunetti A, Aime S, Morelli G, Pedone C
* Characterization of 111In labeled CCK8 peptide coupled to a novel DTPA-like derivative in CCK-B receptor overexpressing cells (402 views)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 2001 Sep; 28(8): N/D-N/D.
Impact Factor: 3.464
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* Repurposing of Copper(II)-chelating Drugs for the Treatment of Neurodegenerative Diseases (855 views)
Curr Med Chem (ISSN: 1875-533xelectronic, 0929-8673linking), 2018 Feb 12; 25(4): 525-539.
Impact Factor: 3.249
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Barresi V, Spampinato G, Musso N, Trovato Salinaro A, Rizzarelli E, Condorelli DF
* ATOX1 gene silencing increases susceptibility to anticancer therapy based on copper ionophores or chelating drugs (724 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2016; 156: 145-152.
Impact Factor: 3.348
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Nardon C, Boscutti G, Dalla Via L, Ringhieri P, Di Noto V, Morelli G, Accardo A, Fregona D
* CCK8 peptide-labeled Pluronic® F127 micelles as a targeted vehicle of gold-based anticancer chemotherapeutics (470 views)
Medchemcomm (ISSN: 2040-2503), 2015; 6(1): 155-163.
Impact Factor: 2.319
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Accardo A, Ringhieri P, Szekely N, Pipich V, Luchini A, Paduano L, Tesauro D
* Structural insights on nanoparticles containing gadolinium complexes as potential theranostic (471 views)
Colloid Polym Sci (ISSN: 0303-402x), 2014 May; 292(5): 1121-1127.
Impact Factor: 1.865
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Grasso GI, Arena G, Bellia F, Rizzarelli E, Vecchio G
* Copper(II)-chelating homocarnosine glycoconjugate as a new multifunctional compound (708 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2014 Feb; 131: 56-63.
Impact Factor: 3.444
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Calce E, Monfregola L, De Luca S
* Synthetic Strategy to Prepare DOTA-Based Bifunctional Chelating Agent Ready to Bind Biomolecular Probes (466 views)
Int J Pept Res Ther (ISSN: 1573-3149, 0929-5666), 2013 Sep; 19(3): 199-202.
Impact Factor: 0.825
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Accardo A, Mangiapia G, Paduano L, Morelli G, Tesauro D
* Octreotide labeled aggregates containing platinum complexes as nanovectors for drug delivery (410 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2013 Apr; 19(4): 190-197.
Impact Factor: 1.862
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Accardo A, Mansi R, Salzano G, Morisco A, Aurilio M, Parisi A, Maione F, Cicala C, Ziaco B, Tesauro D, Aloj L, De Rosa G, Morelli G
* Bombesin peptide antagonist for target-selective delivery of liposomal doxorubicin on cancer cells (410 views)
Journal Of Drug Targeting (ISSN: 1061-186x), 2012 Nov 21; 21(3): 240-249.
Impact Factor: 2.768
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Di Fiore A, Maresca A, Supuran CT, De Simone G
* Hydroxamate represents a versatile zinc binding group for the development of new carbonic anhydrase inhibitors (361 views)
Chem Commun (ISSN: 1359-7345, 1364-548x, 1364-548xelectronic), 2012; 48(70): 8838-8840.
Impact Factor: 6.378
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Tornesello AL, Aurilio M, Accardo A, Tarallo L, Barbieri A, Arra C, Tesauro D, Morelli G, Aloj L
* Gastrin and cholecystokinin peptide-based radiopharmaceuticals: An in vivo and in vitro comparison (381 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2011 May; 17(5): 405-412.
Impact Factor: 1.799
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Corona C, Frazzini V, Silvestri E, Lattanzio R, La Sorda R, Piantelli M, Canzoniero LM, Ciavardelli D, Rizzarelli E, Sensi SL
* Effects of dietary supplementation of carnosine on mitochondrial dysfunction, amyloid pathology, and cognitive deficits in 3xTg-AD mice (612 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2011 Mar 15; 6(3): e17971-e17971.
Impact Factor: 4.092
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Accardo A, Morisco A, Gianolio E, Tesauro D, Mangiapia G, Radulescu A, Brandt A, Morelli G
* Nanoparticles containing octreotide peptides and gadolinium complexes for MRI applications (508 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2011 Feb; 17(2): 154-162.
Impact Factor: 1.799
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Accardo A, Morisco A, Tesauro D, Pedone C, Morelli G
* Naposomes: A new class of peptide-derivatized, target-selective multimodal nanoparticles for imaging and therapeutic applications (409 views)
Ther Deliv (ISSN: 2041-5990), 2011 Feb; 2(2): 235-257.
Impact Factor: 0
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Lanza V, Bellia F, D'Agata R, Grasso G, Rizzarelli E, Vecchio G
* New glycoside derivatives of carnosine and analogs resistant to carnosinase hydrolysis: synthesis and characterization of their copper(II) complexes (404 views)
J Chem Res (ISSN: 1873-3344, 0162-0134, 0162-0134print), 2011 Feb; 105(2): 181-188.
Impact Factor: 3.354
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Digilio G, Menchise V, Gianolio E, Catanzaro V, Carrera C, Napolitano R, Fedeli F, Aime S
* Exofacial protein thiols as a route for the internalization of Gd(III)-based complexes for magnetic resonance imaging cell labeling (455 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2010 Jul 8; 53(13): 4877-4890.
Impact Factor: 5.207
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Accardo A, Mansi R, Morisco A, Mangiapia G, Paduano L, Tesauro D, Radulescu A, Aurilio M, Aloj L, Arra C, Morelli G
* Peptide modified nanocarriers for selective targeting of bombesin receptors (429 views)
Mol Biosyst (ISSN: 1742-206x), 2010 May; 6(5): 878-887.
Impact Factor: 3.825
View Export to BibTeX Export to EndNote
Arnesano F, Scintilla S, Calò V, Bonfrate E, Ingrosso C, Losacco M, Pellegrino T, Rizzarelli E, Natile G
* Copper-triggered aggregation of ubiquitin (534 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2009 Sep 16; 4(9): e7052-e7052.
Impact Factor: 4.351
View Export to BibTeX Export to EndNote
Accardo A, Tesauro D, Morisco A, Mangiapia G, Vaccaro M, Gianolio E, Heenan RK, Paduano L, Morelli G
* Micelles obtained by aggregation of gemini surfactants containing the CCK8 peptide and a gadolinium complex (398 views)
J Biol Inorg Chem (ISSN: 0949-8257, 1432-1327electronic, 0949-8257linking), 2009 May; 14(4): 587-599.
Impact Factor: 3.415
View Export to BibTeX Export to EndNote
Ciaccio C, Tundo GR, Grasso G, Spoto G, Marasco D, Ruvo M, Gioia M, Rizzarelli E, Coletta M
* Somatostatin: a novel substrate and a modulator of insulin-degrading enzyme activity (455 views)
J Mol Biol (ISSN: 1089-8638, 0022-2836, 1089-8638electronic), 2009 Feb 6; 385(5): 1556-1567.
Impact Factor: 3.871
View Export to BibTeX Export to EndNote
Accardo A, Tesauro D, Morelli G, Del Pozzo L, Pedone C, Tornesello AL, Benedetti E
* Supramolecular aggregates derivatized by CCK8 peptide as selective nanocarriers for drug delivery (362 views)
Adv Exp Med Biol (ISSN: 0065-2598, 0065-2598print), 2009; 611: 603-604.
Impact Factor: 2.02
View Export to BibTeX Export to EndNote
Vaccaro M, Mangiapia G, Accardo A, Tesauro D, Gianolio E, Frielinghaus H, Morelli G, Paduano L
* Polymerized mixed aggregates containing gadolinium complex and CCK8 peptide (429 views)
Colloid Polym Sci (ISSN: 0303-402x), 2008 Dec; 286(14-15): 1643-1652.
Impact Factor: 1.736
View Export to BibTeX Export to EndNote
Accardo A, Tesauro D, Aloj L, Tarallo L, Arra C, Mangiapia G, Vaccaro M, Pedone C, Paduano L, Morelli G
* Peptide-containing aggregates as selective nanocarriers for therapeutics (392 views)
Chemmedchem (ISSN: 1860-7179, 1860-7187, 1860-7187electronic), 2008 Apr; 3(4): 594-602.
Impact Factor: 3.15
View Export to BibTeX Export to EndNote
D'Andrea LD, Testa I, Panico M, Di Stasi R, Carac C, Tarallo L, Arra C, Barbieri A, Romanelli A, Aloj L
* In vivo and in vitro characterization of CCK8 bearing a histidine-based chelator labeled with Tc-99m-tricarbonyl (424 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2008; 90(5): 707-712.
Impact Factor: 2.823
View Export to BibTeX Export to EndNote
Vaccaro M, Accardo A, D'Errico G, Schillen K, Radulescu A, Tesauro D, Morelli G, Paduano L
* Peptides and gd complexes containing colloidal assemblies as tumor-specific contrast agents in MRI: Physicochemical characterization (399 views)
Biophysical Journal (ISSN: 0006-3495, 1542-0086), 2007 Sep; 93(5): 1736-1746.
Impact Factor: 4.627
View Export to BibTeX Export to EndNote
Cuzzocrea S, Genovese T, Failla M, Vecchio G, Fruciano M, Mazzon E, Di Paola R, Muià C, La Rosa C, Crimi N, Rizzarelli E, Vancheri C
* Protective effect of orally administered carnosine on bleomycin-induced lung injury (721 views)
Am J Physiol Lung Cell Mol Physiol (ISSN: 1040-0605), 2007 May; 292(5): L1095-L1095.
Impact Factor: 4.214
View Export to BibTeX Export to EndNote
Agostini S, Bolzati C, Didonè E, Cavazza-Ceccato M, Refosco F, Aloj L, Arra C, Aurilio M, Tornesello AL, Tesauro D, Morelli G
* The (Tc(N)(PNP))2+ metal fragment labeled cholecystokinin-8 (CCK8) peptide for CCK-2 receptors imaging: In vitro and in vivo studies (410 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2007 Apr; 13(4): 211-219.
Impact Factor: 1.768
View Export to BibTeX Export to EndNote
Accardo A, Tesauro D, Morelli G, Gianolio E, Aime S, Vaccaro M, Mangiapia G, Paduano L, Schillén K
* High-relaxivity supramolecular aggregates containing peptides and Gd complexes as contrast agents in MRI (433 views)
J Biol Inorg Chem (ISSN: 0949-8257, 1432-1327electronic, 0949-8257print), 2007 Feb; 12(2): 267-276.
Impact Factor: 3.325
View Export to BibTeX Export to EndNote
Accardo A, Tesauro D, Mangiapia G, Pedone C, Morelli G
* Nanostructures by self-assembling peptide amphiphile as potential selective drug carriers (438 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2007; 88(2): 115-121.
Impact Factor: 2.389
View Export to BibTeX Export to EndNote
De Luca S, Sanseverino M, Zocchi I, Pedone C, Morelli G, Ragone R
* Receptor fragment approach to the binding between CCK8 peptide and cholecystokinin receptors: A fluorescence study on type B receptor fragment CCKB-R (352-379) (371 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2005 Mar; 77(4): 205-211.
Impact Factor: 2.545
View Export to BibTeX Export to EndNote
De Luca S, Morelli G
* Synthesis and characterization of a sulfated and a non-sulfated cyclic CCK8 analogue functionalized with a chelating group for metal labelling (395 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2004 May; 10(5): 265-273.
Impact Factor: 1.652
View Export to BibTeX Export to EndNote
Mansi R, Tesauro D, De Capua A, Fattorusso R, Carac C, Aloj L, Benedetti E, Morelli G
* Peptide-chelating agent conjugate for selective targeting of somatostatin receptor type 1: Synthesis and characterization (472 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2004; 76(6): 527-534.
Impact Factor: 2.863
View Export to BibTeX Export to EndNote
Morelli G, De Luca S, Tesauro D, Saviano M, Pedone C, Dolmella A, Visentin R, Mazzi U
* CCK8 peptide derivatized with diphenylphosphine for rhenium labelling: Synthesis and molecular mechanics calculations (325 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2002 Jul; 8(7): 373-381.
Impact Factor: 1.691
View Export to BibTeX Export to EndNote
Aloj L, Zannetti A, Caraco C, Del Vecchio S, Tasauro D, De Luca S, Brunetti A, Aime S, Morelli G, Pedone C
* Characterization of 111In labeled CCK8 peptide coupled to a novel DTPA-like derivative in CCK-B receptor overexpressing cells (402 views)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 2001 Sep; 28(8): N/D-N/D.
Impact Factor: 3.464
View Export to BibTeX Export to EndNote
33 Records (29 excluding Abstracts).
Total impact factor: 96.038 (79.917 excluding Abstracts).
Total 5 year impact factor: 98.439 (80.533 excluding Abstracts).
Total impact factor: 96.038 (79.917 excluding Abstracts).
Total 5 year impact factor: 98.439 (80.533 excluding Abstracts).
410 views. Last view on Monday 24 April 2023, 9:04:37
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