Department of Organic and Industrial Chemistry, University of Parma, Viale G.P. Usberti 17/A, 43100 Parma, Italy
Institute of Biostructure and Bioimaging, CNR - Naples, Naples, Italy
Department of Chemical Sciences, University of Catania, Catania, Italy
Laboratory for the Development of Pharmacological and Pharmacogenomic Therapy of Thalassaemia, Biotechnology Center, University of Ferrara, Ferrara, Italy
BioPharmaNet, Department of Biochemistry and Molecular Biology, University of Ferrara, Ferrara, Italy
References: Li, S.D., Huang, L., Targeted delivery of siRNA by nonviral vectors: Lessons learned from recent advances (2008) Curr Opin Investig Drugs, 9, pp. 1317-132
López-Fraga, M., Wright, N., Jiménez, A., RNA interference-based therapeutics: New strategies to fight infectious disease (2008) Infect Disord Drug Targets, 8, pp. 262-273
Huang, C., Li, M., Chen, C., Yao, Q., Small interfering RNA therapy in cancer: Mechanism, potential targets, and clinical applications (2008) Expert Opin Ther Targets, 12, pp. 637-645
Shrivastava, N., Srivastava, A., RNA interference: An emerging generation of biologicals Biotechnol, J 2008 (3), pp. 339-353
Sahu, N.K., Shilakari, G., Nayak, A., Kohli, D.V., Antisense technology, a selective tool for gene expression regulation and gene targeting (2007) Curr Pharm Biotechnol, 8, pp. 291-304
Orlacchio, A., Bernardi, G., Orlacchio, A., Martino, S., RNA interference as a tool for Alzheimer's disease therapy (2007) Mini Rev Med Chem, 7, pp. 1166-1176
Williams, A.E., Perry, M.M., Moschos, S.A., Larner-Svensson, H.M., Lindsay, M.A., Role of miRNA-146a in the regulation of the innate immune response and cancer (2008) Biochem Soc Trans, 36 (PART 6), pp. 1211-1215
Papagiannakopoulos, T., Kosik, K.S., Micro RNAs: Regulators of oncogenesis and sternness (2008) BMC Med, 6, p. 15
Garzon, R., Croce, C.M., Micro RNAs in normal and malignant hematopoiesis (2008) Curr Opin Hematol, 15, pp. 352-358
Mascellani, N., Tagliavini, L., Gamberoni, G., Rossi, S., Marchesini, J., Taccioli, C., Using miRNA expression data for the study of human cancer (2008) Minerva Biotecnologica, 20, pp. 23-30
Sontheimer, E.J., Carthew, R.W., Silence from within: Endogenous siRNAs and miRNAs (2005) Cell, 122, pp. 9-12
Filipowicz, W., Jaskiewicz, L., Kolb, F.A., Pillai, R.S., Post-transcriptional gene silencing by siRNAs and miRNAs (2005) Curr Opin Struct Biol, 15, pp. 331-341
Alvarez-Garcia, I., Miska, E.A., Micro RNA functions in animal development and human disease (2005) Development, 132, pp. 4653-4662
Bartel, D.P., (2004) Micro RNAs: Genomics, biogenesis, mechanism, and function, 116, pp. 281-297. , Cell
Plasterk, R.H., Micro RNAs in animal development (2006) Cell, 124, pp. 877-881
He, L., Hannon, G.J., Micro RNAs: Small RNAs with a big role in gene regulation (2004) Nat Rev Genet, 5, pp. 522-531
Felli, N., Fontana, L., Pelosi, E., Giorgi, F., Marcocci, C., Taddei, A.R., Micro RNAs 221 and 222 inhibit normal erythropoiesis and erythroleukemic cell growth via kit receptor down-modulation (2005) Proc Natl Acad Sci U S A, 102, pp. 18081-18086
Stenvang, J., Kauppinen, S., Micro RNAs as targets for antisense-based therapeutics (2008) Expert Opin Biol Ther, 8, pp. 59-81
Lowery, A.J., Miller, N., McNeill, R.E., Kerin, M.J., Micro RNAs as prognostic indicators and therapeutic targets: Potential effect on breast cancer management (2008) Clin Cancer Res, 14, pp. 360-365
Cho, W.C., OncomiRs: The discovery and progress of microRNAs in cancers (2007) Mol Cancer, 6, p. 60
Habbe, N., Koorstra, J.B., Mendell, J.T., Offerhaus, G.J., Ryu, J.K., Feldmann, G., Micro RNA miR-155 is a biomarker of early pancreatic neoplasia (2009) Cancer Biol Ther, 8, pp. 25-31
Xiao, B., Guo, J., Miao, Y., Jiang, Z., Huan, R., Zhang, Y., Detection of miR-106a in gastric carcinoma and its clinical significance (2009) Clin Chim Acta, 400, pp. 97-102
Nicoloso, M.S., Calin, G.A., Micro RNA involvement in brain tumors: From bench to bedside (2008) Brain Pathol, 18, pp. 122-129
Nielsen, P.E., Egholm, M., Berg, R.H., Buchardt, O., Sequence-selective recognition of DNA by strand displacement with a thymine-substituted polyamide (1991) Science, 254, pp. 1497-1500
Egholm, M., Buchardt, O., Christensen, L., Behrens, C., Freier, S.M., Driver, D.A., PNA hybridizes to complementary oligonucleotides obeying the Watson-Crick hydrogen-bonding rules (1993) Nature, 365, pp. 566-568
Lundin, K.E., Good, L., Strömberg, R., Gräslund, A., Smith, C.I., Biological activity and biotechnological aspects of peptide nucleic acid (2006) Adv Genet, 56, pp. 1-51
Feriotto, G., Corradini, R., Sforza, S., Bianchi, N., Mischiati, C., Marchelli, R., Peptide nucleic acids and biosensor technology for realtime detection of the cystic fibrosis W1282X mutation by surface plasmon resonance (2001) Lab Invest, 81, pp. 1415-1427
Demidov, V.V., Potaman, V.N., Frank-Kamenetskii, M.D., Egholm, M., Buchard, O., Sonnichsen, S.H., Stability of peptide nucleic acids in human serum and cellular extracts (1994) Biochem Pharmacol, 48, pp. 1310-1313
Larsen, H.J., Nielsen, P.E., Transcription-mediated binding of peptide nucleic acid (PNA) to double-stranded DNA: Sequence-specific suicide transcription (1996) Nucleic Acids Res, 24, pp. 458-463
Gambari, R., Biological activity and delivery of peptide nucleic acids (PNA)-DNA chimeras for transcription factor decoy (TFD) pharmacotherapy (2004) Curr Med Chem, 11, pp. 1253-1263
Nielsen, P.E., Gene targeting using peptide nucleic acid (2005) Methods Mol Biol, 288, pp. 343-358
Nielsen, E., RNA targeting using peptide nucleic acid (2006) Handb Exp Pharmacol, 173, pp. 395-403
Yin, H., Lu, Q., Wood, M., Effective exon skipping and restoration of dystrophin expression by peptide nucleic acid antisense oligonucleotides in mdx mice (2008) Mol Ther, 16, pp. 38-45
Bonham, M.A., Brown, S., Boyd, A.L., Brown, P.H., Bruckenstein, D.A., Hanvey, J.C., An assessment of the antisense properties of RNase H-competent and steric-blocking oligomers (1995) Nucleic Acids Res, 23, pp. 1197-1203
Corradini, R., Feriotto, G., Sforza, S., Marchelli, R., Gambari, R., Enhanced recognition of cystic fibrosis W1282X DNA point mutation by chiral peptide nucleic acid probes by a surface plasmon resonance biosensor (2004) J Mol Recognit, 17, pp. 76-84
Sforza, S., Corradini, R., Ghirardi, S., Dossena, A., Marchelli, R., DNA binding of a D-lysine-based chiral PNA: Direction control and mismatch recognition (2000) Eur J Org Chem 2000, pp. 2905-2913
Tedeschi, T., Chiari, M., Galaverna, G., Sforza, S., Cretich, M., Corradini, R., Marchelli Detection of the R553X DNA single point mutation related to cystic fibrosis by a "chiral box" D-lysine-peptide nucleic acid probe by capillary Electrophoresis (2005) Electrophoresis, 26, pp. 4310-4316
Tedeschi, T., Sforza, S., Corradini, R., Marchelli, R., Synthesis of new chiral PNAs bearing a dipeptide-mimic monomer with two lysine-derived stereogenic centres (2005) Tetrahedron Lett, 46, pp. 8395-8399
Sforza, S., Tedeschi, T., Corradini, R., Marchelli, R., Induction of helical handedness and DNA binding properties of peptide nucleic acids (PNAs) with two stereogenic centres (2007) Eur J Org Chem 2007, pp. 5879-5885
Wojciechowski, F., Hudson, R.H.E., Nucleobase modifications in peptide nucleic acids (2007) Curr Top Med Chem, 7, pp. 667-679
Romanelli, A., Pedone, C., Saviano, M., Bianchi, N., Borgatti, M., Mischiati, C., Molecular interactions with nuclear factor kappaB (NF-kappaB) transcription factors of a PNA-DNA chimera mimicking NF-kappaB binding sites (2001) Eur J Biochem, 268, pp. 6066-6075
D'Agata, R., Grasso, G., Spoto, G., Real-Time Binding Kinetics Monitored with Surface Plasmon Resonance Imaging in a Diffusion-Free Environment (2008) Open Spectr J, 1, pp. 1-9
D'Agata, R., Corradini, R., Grasso, G., Marchelli, R., Spoto, G., Ultrasensitive detection of DNA by PNA and nanoparticle-enhanced surface plasmon resonance imaging (2008) ChemBioChem, 9, pp. 2067-2070
Triboulet, R., Mari, B., Lin, Y.L., Chable-Bessia, C., Bennasser, Y., Lebrigand, K., Suppression of microRNA-silencing pathway by HIV-1 during virus replication (2007) Science, 315, pp. 1579-1582
Krützfeldt, J., Rajewsky, N., Braich, R., Rajeev, K.G., Tuschl, T., Manoharan, M., Silencing of microRNAs in vivo with 'antagomirs' (2005) Nature, 438, pp. 685-689
Elmén, J., Lindow, M., Silahtaroglu, A., Bak, M., Christensen, M., Lind-Thomsen, A., Antagonism of microRNA-122 in mice by systemically administered LNA-antimiR leads to up-regulation of a large set of predicted target mRNAs in the liver (2008) Nucleic Acids Res, 36, pp. 1153-1162
Fabani, M.M., Gait, M.J., miR-122 targeting with LNA/2′-O-methyl oligonucleotide mixmers, peptide nucleic acids (PNA), and PNA-peptide conjugates (2008) RNA, 14, pp. 336-346
Li, S. D., Huang, L., Targeted delivery of siRNA by nonviral vectors: Lessons learned from recent advances (2008) Curr Opin Investig Drugs, 9, pp. 1317-132
L pez-Fraga, M., Wright, N., Jim nez, A., RNA interference-based therapeutics: New strategies to fight infectious disease (2008) Infect Disord Drug Targets, 8, pp. 262-273
Sahu, N. K., Shilakari, G., Nayak, A., Kohli, D. V., Antisense technology, a selective tool for gene expression regulation and gene targeting (2007) Curr Pharm Biotechnol, 8, pp. 291-304
Williams, A. E., Perry, M. M., Moschos, S. A., Larner-Svensson, H. M., Lindsay, M. A., Role of miRNA-146a in the regulation of the innate immune response and cancer (2008) Biochem Soc Trans, 36 (PART 6), pp. 1211-1215
Sontheimer, E. J., Carthew, R. W., Silence from within: Endogenous siRNAs and miRNAs (2005) Cell, 122, pp. 9-12
Bartel, D. P., (2004) Micro RNAs: Genomics, biogenesis, mechanism, and function, 116, pp. 281-297. , Cell
Plasterk, R. H., Micro RNAs in animal development (2006) Cell, 124, pp. 877-881
He, L., Hannon, G. J., Micro RNAs: Small RNAs with a big role in gene regulation (2004) Nat Rev Genet, 5, pp. 522-531
Lowery, A. J., Miller, N., McNeill, R. E., Kerin, M. J., Micro RNAs as prognostic indicators and therapeutic targets: Potential effect on breast cancer management (2008) Clin Cancer Res, 14, pp. 360-365
Cho, W. C., OncomiRs: The discovery and progress of microRNAs in cancers (2007) Mol Cancer, 6, p. 60
Nicoloso, M. S., Calin, G. A., Micro RNA involvement in brain tumors: From bench to bedside (2008) Brain Pathol, 18, pp. 122-129
Nielsen, P. E., Egholm, M., Berg, R. H., Buchardt, O., Sequence-selective recognition of DNA by strand displacement with a thymine-substituted polyamide (1991) Science, 254, pp. 1497-1500
Lundin, K. E., Good, L., Str mberg, R., Gr slund, A., Smith, C. I., Biological activity and biotechnological aspects of peptide nucleic acid (2006) Adv Genet, 56, pp. 1-51
Demidov, V. V., Potaman, V. N., Frank-Kamenetskii, M. D., Egholm, M., Buchard, O., Sonnichsen, S. H., Stability of peptide nucleic acids in human serum and cellular extracts (1994) Biochem Pharmacol, 48, pp. 1310-1313
Larsen, H. J., Nielsen, P. E., Transcription-mediated binding of peptide nucleic acid (PNA) to double-stranded DNA: Sequence-specific suicide transcription (1996) Nucleic Acids Res, 24, pp. 458-463
Nielsen, P. E., Gene targeting using peptide nucleic acid (2005) Methods Mol Biol, 288, pp. 343-358
Bonham, M. A., Brown, S., Boyd, A. L., Brown, P. H., Bruckenstein, D. A., Hanvey, J. C., An assessment of the antisense properties of RNase H-competent and steric-blocking oligomers (1995) Nucleic Acids Res, 23, pp. 1197-1203
Kr tzfeldt, J., Rajewsky, N., Braich, R., Rajeev, K. G., Tuschl, T., Manoharan, M., Silencing of microRNAs in vivo with 'Antagomirs' (2005) Nature, 438, pp. 685-689
Elm n, J., Lindow, M., Silahtaroglu, A., Bak, M., Christensen, M., Lind-Thomsen, A., Antagonism of microRNA-122 in mice by systemically administered LNA-antimiR leads to up-regulation of a large set of predicted target mRNAs in the liver (2008) Nucleic Acids Res, 36, pp. 1153-1162
Fabani, M. M., Gait, M. J., miR-122 targeting with LNA/2 -O-methyl oligonucleotide mixmers, peptide nucleic acids (PNA), and PNA-peptide conjugates (2008) RNA, 14, pp. 336-346
PNAs targeting the "RNA world": Micro RNA next?
Since non-viral gene therapy was developed and employed in different in vitro and in vivo experimental systems as an effective way to control and modify gene expression, RNA has been considered as a molecular target of great relevance. Due to the recent identification and characterization of micro RNA as molecules of great interest in the control of several biological functions, this new class of RNA molecules have been proposed as potential target of molecular intervention finalized to control gene expression. Accordingly, the novel class of chemically engineered oligonucleotides, termed "anta-gomirs", are efficient and specific silencers of endogenous micro RNAS. Peptide nucleic acids (PNAs) and PNA-peptide conjugates are under study as micro RNA inhibitors, and are expected to be more effective than standard 2′-O-methyl oligonucleotides in binding and inhibitory effects on micro RNA action.
Kim YH, Shin SW, Pellicano R, Fagoonee S, Choi IJ, Kim YI, Park B, Choi JM, Kim SG, Choi J, Park JY, Oh S, Yang HJ, Lim JH, Im JP, Kim JS, Jung HC, Ponzetto A, Figura N, Malfertheiner P, Choi IJ, Kook MC, Kim YI, Cho SJ, Lee JY, Kim CG, Park B, Nam BH, Bae SE, Choi KD, Choe J, Kim SO, Na HK, Choi JY, Ahn JY, Jung KW, Lee J, Kim DH, Chang HS, Song HJ, Lee GH, Jung HY, Seta T, Takahashi Y, Noguchi Y, Shikata S, Sakai T, Sakai K, Yamashita Y, Nakayama T, Leja M, Park JY, Murillo R, Liepniece-karele I, Isajevs S, Kikuste I, Rudzite D, Krike P, Parshutin S, Polaka I, Kirsners A, Santare D, Folkmanis V, Daugule I, Plummer M, Herrero R, Tsukamoto T, Nakagawa M, Kiriyama Y, Toyoda T, Cao X, Corral JE, Mera R, Dye CW, Morgan DR, Lee YC, Lin JT, Garcia Martin R, Matia Cubillo A, Lee SH, Park JM, Han YM, Ko WJ, Hahm KB, Leontiadis GI, Ford AC, Ichinose M, Sugano K, Jeong M, Park JM, Han YM, Park KY, Lee DH, Yoo JH, Cho JY, Hahm KB, Bang CS, Baik GH, Shin IS, Kim JB, Suk KT, Yoon JH, Kim YS, Kim DJ * Helicobacter pylori Eradication for Prevention of Metachronous Recurrence after Endoscopic Resection of Early Gastric Cancer(297 views) N Engl J Med (ISSN: 0028-4793, 0028-4793linking, 1533-4406electronic), 2015 Jun; 30642104201566393291: 749-756. Impact Factor:59.558 ViewExport to BibTeXExport to EndNote