Pathophysiological changes of gram-negative bacterial infection can be reproduced by a synthetic peptide mimicking loop L7 sequence of Haemophilus influenzae porin (323 views)
Microbes And Infection / Institut Pasteur (ISSN: 1286-4579), 2008 May; 10(6): 657-663.
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Paper type: Journal Article,
Impact factor: 2.801, 5-year impact factor: 3.045
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-44449137867&partnerID=40&md5=d06f5c13325bdb08cd7715de1a8b20a3
Keywords: Coagulation, Endothelial Injury, Fibrinolysis, Inflammation, Loop L7, Cytokine, Endothelial Leukocyte Adhesion Molecule 1, Glucose, Plasminogen Activator Inhibitor 1, Porin, Synthetic Peptide, Tissue Plasminogen Activator, Von Willebrand Factor, Animal Experiment, Animal Model, Animal Tissue, Article, Blood Clotting, Controlled Study, Cytokine Production, Endothelium Injury, Haemophilus Influenzae Type B, Hemodynamics, Hyperglycemia, Immunoreactivity, Nonhuman, Pathophysiology, Priority Journal, Septic Shock, Amino Acid Motifs, Bacterial Proteins, Disease Models, Gram-Negative Bacterial Infections, Sprague-Dawley, Bacteria (microorganisms), Haemophilus Influenzae Serotype B, Negibacteria, Rattus,
Affiliations:
*** IBB - CNR ***
Department of Experimental Medicine-II University of Naples, Via De Crecchio 7, 80138 Naples, Italy.
Department of Biological Sciences, Division of Biostructures - University of Naples Federico II, Istituto di Biostrutture, Via Mezzocannone 16, 80134 Naples, Italy
References:
Parrillo, J.E., Pathogenetic mechanisms of septic shock (1999) N. Engl. J. Med., 328, pp. 1471-147
Huntley, J.F., Conley, P.G., Hagman, K.E., Norgard, M.V., Characterization of Francisella tularensis outer membrane proteins (2007) J. Bacteriol., 189, pp. 561-574
Galdiero, M., Palomba, E., De Martino, L., Vitiello, M., Pagnini, P., Effects of the major Pasteurella multocida porin on bovine neutrophils (1998) Am. J. Vet. Res., 59, pp. 1270-1274
Galdiero, M., Vitiello, M., Galdiero, S., Eukaryotic cell signaling and transcriptional activation induced by bacterial porins (2003) FEMS Microbiol. Lett., 226, pp. 57-64
Achouak, W., Heulin, T., Pages, J.M., Multiple facets of bacterial porins (2001) FEMS Microbiol. Lett., 199, pp. 1-7
Galdiero, F., Sommese, L., Scarfogliero, P., Galdiero, M., Biological activities-lethality, Shwartzman reaction and pyrogenicity of Salmonella typhimurium porins (1994) Microb. Pathog., 16, pp. 111-116
Vitiello, M., D'Isanto, M., Galdiero, M., Raieta, K., Tortora, A., Rotondo, P., Peluso, L., Galdiero, M., Interleukin-8 production by THP-1 cells stimulated by Salmonella enterica serovar Typhimurium porins is mediated by AP-1, NF-kappaB and MAPK pathways (2004) Cytokine, 27, pp. 15-24
Galdiero, M., Galdiero, M., Finamore, E., Rossano, F., Gambuzza, M., Catania, M.R., Teti, G., Mancuso, G., Haemophilus influenzae porin induces toll-like receptor 2-mediated cytokine production in human monocytes and mouse macrophages (2004) Infect. Immun., 72, pp. 1204-1209
Galdiero, M., D'Amico, M., Gorga, F., Di Filippo, C., D'Isanto, M., Vitiello, M., Longanella, A., Tortora, A., Haemophilus influenzae porin contributes to signaling of the inflammatory cascade in rat brain (2001) Infect. Immun., 69, pp. 221-227
Weiss, M.S., Schulz, G.E., Structure of porin refined at 1.8 A resolution (1992) J. Mol. Biol., 227, pp. 493-509
Koebnik, R., Locker, K.P., Van Gelder, P., Structure and function of bacterial outer membrane proteins: barrels in a nutshell (2000) Mol. Microbiol., 37, pp. 239-253
Galdiero, S., Capasso, D., Vitiello, M., D'Isanto, M., Pedone, C., Galdiero, M., Role of surface-exposed loops of Haemophilus influenzae protein P2 in the mitogen-activated protein kinase cascade (2003) Infect. Immun., 71, pp. 2798-2809
Galdiero, S., Vitiello, M., Amodeo, P., D'Isanto, M., Cantisani, M., Pedone, C., Galdiero, M., Structural requirements for proinflammatory activity of porin P2 loop 7 from Haemophilus influenzae (2006) Biochemistry, 45, pp. 4491-4501
Yi, K., Murphy, T.F., Importance of an immunodominant surface exposed loop on outer membrane protein P2 of nontypeable Haemophilus influenzae (1997) Infect. Immun., 65, pp. 150-155
Neary, J.M., Yi, K., Karalus, R.J., Murphy, T.F., Antibodies to loop 6 of the P2 porin protein of nontypeable Haemophilus influenzae are bactericidal against multiple strains (2001) Infect. Immun., 69, pp. 773-778
Sukumaran, S., Hauser, K., Maier, E., Benz, R., Mantele, W., Structure-function correlation of outer membrane protein porin from Paracoccus denitrificans (2006) Biopolymers, 82, pp. 344-348
Vincent, J.L., Sun, Q., Dubois, M.J., Clinical trials of immunomodulatory therapies in severe sepsis and septic shock (2002) Clin. Infect. Dis., 34, pp. 1084-1093
Opal, S.M., Gluck, T., Endotoxin as a drug target (2003) Crit. Care Med., 31, pp. 57-64
Boos, C.J., Goon, P.K., Lip, G.Y., The endothelium, inflammation, and coagulation in sepsis (2006) Clin. Pharmacol. Ther., 79, pp. 20-22
Lowe, G.D., The relationship between infection, inflammation, and cardiovascular disease: an overview (2001) Ann. Periodontol., 6, pp. 1-8
Aird, W.C., The role of the endothelium in severe sepsis and multiple organ dysfunction syndrome (2003) Blood, 101, pp. 3765-3777
Lowry, O.H., Rosebrough, N.J., Farr, A.L., Randall, R.J., Protein measurement with the Folin phenol reagent (1951) J. Biol. Chem., 193, pp. 265-275
Laemmli, U.K., Cleavage of structural proteins during the assembly of the head of bacteriophage T4 (1970) Nature, 277, pp. 680-685
Tsai, C.M., Frasch, C.E., A sensitive silver stain for detecting lipopolysaccharides in polyacrylamide gels (1982) Anal. Biochem., 119, pp. 115-119
Yin, E.T., Galanos, C., Kinsky, S., A Bradshaw, R., Wessler, S., Luderity, O., Sarmiento, M.F., Picogram-sensitive assay for endotoxin: gelation of Limulus polyphemus blood cell lysate induced by purified lipopolysaccharides and lipid A from Gram-negative bacteria (1972) Biochim. Biophys. Acta, 261, pp. 284-289
Issekutz, A.C., Removal of gram-negative endotoxin from solutions by affinity chromatography (1983) J. Immunol. Methods, 61, pp. 275-281
Hölm, S., A simple sequentially rejective multiple test procedure (1979) Scand. J. Statist., 6, pp. 65-70
Wang, Y.X., Dong, N., Wu, C., Martin-McNulty, B., Fitch, R.M., da Cunha, V., Vicelette, J., Wu, Q., Lipopolysaccharide attenuates thrombolysis in batroxobin-induced lung vasculature fibrin deposition but not in ferrous chloride-induced carotid artery thrombus in rats: role of endogenous PAI-1 (2003) Thromb. Res., 111, pp. 381-387
Kayal, S., Jais, J.P., Aguini, N., Chaudiere, J., Labrousse, J., Elevated circulating E-selectin, intercellular adhesion molecule 1, and von Willebrand factor in patients with severe infection (1998) Am. J. Respir. Crit. Care Med., 157, pp. 776-784
Schweda, E.K.H., Richards, J.C., Hood, D.W., Moxon, E.R., Expression and structural diversity of the lipopolysaccharide of Haemophilus influenzae: implication in virulence (2007) Int. J. Med. Microbiol., 297, pp. 297-306
Shen, K.P., Lo, Y.C., Yang, R.C., Liu, H.W., Chen, I.J., Wu, B.N., Antioxidanteugenosedin-A protects against lipopolysaccharide-induced hypotension, hyperglycaemia and cytokine immunoreactivity in rats and mice (2005) J. Pharm. Pharmacol., 57, pp. 117-125
Xia, Y., Krukoff, T.L., Cardiovascular responses to subseptic doses of endotoxin contribute to differential neuronal activation in rat brain (2001) Brain Res. Mol. Brain Res., 89, pp. 71-85
Galdiero, M., Folgore, A., Molitierno, M., Greco, R., Porins and lipopolysaccharide (LPS) from Salmonella typhimurium induce leucocyte transmigration through human endothelial cells in vitro (1999) Clin. Exp. Immunol., 116, pp. 453-461
Parrillo, J. E., Pathogenetic mechanisms of septic shock (1999) N. Engl. J. Med., 328, pp. 1471-147
Huntley, J. F., Conley, P. G., Hagman, K. E., Norgard, M. V., Characterization of Francisella tularensis outer membrane proteins (2007) J. Bacteriol., 189, pp. 561-574
Weiss, M. S., Schulz, G. E., Structure of porin refined at 1. 8 A resolution (1992) J. Mol. Biol., 227, pp. 493-509
Yi, K., Murphy, T. F., Importance of an immunodominant surface exposed loop on outer membrane protein P2 of nontypeable Haemophilus influenzae (1997) Infect. Immun., 65, pp. 150-155
Neary, J. M., Yi, K., Karalus, R. J., Murphy, T. F., Antibodies to loop 6 of the P2 porin protein of nontypeable Haemophilus influenzae are bactericidal against multiple strains (2001) Infect. Immun., 69, pp. 773-778
Vincent, J. L., Sun, Q., Dubois, M. J., Clinical trials of immunomodulatory therapies in severe sepsis and septic shock (2002) Clin. Infect. Dis., 34, pp. 1084-1093
Opal, S. M., Gluck, T., Endotoxin as a drug target (2003) Crit. Care Med., 31, pp. 57-64
Boos, C. J., Goon, P. K., Lip, G. Y., The endothelium, inflammation, and coagulation in sepsis (2006) Clin. Pharmacol. Ther., 79, pp. 20-22
Lowe, G. D., The relationship between infection, inflammation, and cardiovascular disease: an overview (2001) Ann. Periodontol., 6, pp. 1-8
Aird, W. C., The role of the endothelium in severe sepsis and multiple organ dysfunction syndrome (2003) Blood, 101, pp. 3765-3777
Lowry, O. H., Rosebrough, N. J., Farr, A. L., Randall, R. J., Protein measurement with the Folin phenol reagent (1951) J. Biol. Chem., 193, pp. 265-275
Laemmli, U. K., Cleavage of structural proteins during the assembly of the head of bacteriophage T4 (1970) Nature, 277, pp. 680-685
Tsai, C. M., Frasch, C. E., A sensitive silver stain for detecting lipopolysaccharides in polyacrylamide gels (1982) Anal. Biochem., 119, pp. 115-119
Yin, E. T., Galanos, C., Kinsky, S., A Bradshaw, R., Wessler, S., Luderity, O., Sarmiento, M. F., Picogram-sensitive assay for endotoxin: gelation of Limulus polyphemus blood cell lysate induced by purified lipopolysaccharides and lipid A from Gram-negative bacteria (1972) Biochim. Biophys. Acta, 261, pp. 284-289
Issekutz, A. C., Removal of gram-negative endotoxin from solutions by affinity chromatography (1983) J. Immunol. Methods, 61, pp. 275-281
H lm, S., A simple sequentially rejective multiple test procedure (1979) Scand. J. Statist., 6, pp. 65-70
Wang, Y. X., Dong, N., Wu, C., Martin-McNulty, B., Fitch, R. M., da Cunha, V., Vicelette, J., Wu, Q., Lipopolysaccharide attenuates thrombolysis in batroxobin-induced lung vasculature fibrin deposition but not in ferrous chloride-induced carotid artery thrombus in rats: role of endogenous PAI-1 (2003) Thromb. Res., 111, pp. 381-387
Schweda, E. K. H., Richards, J. C., Hood, D. W., Moxon, E. R., Expression and structural diversity of the lipopolysaccharide of Haemophilus influenzae: implication in virulence (2007) Int. J. Med. Microbiol., 297, pp. 297-306
Shen, K. P., Lo, Y. C., Yang, R. C., Liu, H. W., Chen, I. J., Wu, B. N., Antioxidanteugenosedin-A protects against lipopolysaccharide-induced hypotension, hyperglycaemia and cytokine immunoreactivity in rats and mice (2005) J. Pharm. Pharmacol., 57, pp. 117-125
Microbes And Infection / Institut Pasteur (ISSN: 1286-4579), 2008 May; 10(6): 657-663.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 2.801, 5-year impact factor: 3.045
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-44449137867&partnerID=40&md5=d06f5c13325bdb08cd7715de1a8b20a3
Keywords: Coagulation, Endothelial Injury, Fibrinolysis, Inflammation, Loop L7, Cytokine, Endothelial Leukocyte Adhesion Molecule 1, Glucose, Plasminogen Activator Inhibitor 1, Porin, Synthetic Peptide, Tissue Plasminogen Activator, Von Willebrand Factor, Animal Experiment, Animal Model, Animal Tissue, Article, Blood Clotting, Controlled Study, Cytokine Production, Endothelium Injury, Haemophilus Influenzae Type B, Hemodynamics, Hyperglycemia, Immunoreactivity, Nonhuman, Pathophysiology, Priority Journal, Septic Shock, Amino Acid Motifs, Bacterial Proteins, Disease Models, Gram-Negative Bacterial Infections, Sprague-Dawley, Bacteria (microorganisms), Haemophilus Influenzae Serotype B, Negibacteria, Rattus,
Affiliations:
*** IBB - CNR ***
Department of Experimental Medicine-II University of Naples, Via De Crecchio 7, 80138 Naples, Italy.
Department of Biological Sciences, Division of Biostructures - University of Naples Federico II, Istituto di Biostrutture, Via Mezzocannone 16, 80134 Naples, Italy
References:
Parrillo, J.E., Pathogenetic mechanisms of septic shock (1999) N. Engl. J. Med., 328, pp. 1471-147
Huntley, J.F., Conley, P.G., Hagman, K.E., Norgard, M.V., Characterization of Francisella tularensis outer membrane proteins (2007) J. Bacteriol., 189, pp. 561-574
Galdiero, M., Palomba, E., De Martino, L., Vitiello, M., Pagnini, P., Effects of the major Pasteurella multocida porin on bovine neutrophils (1998) Am. J. Vet. Res., 59, pp. 1270-1274
Galdiero, M., Vitiello, M., Galdiero, S., Eukaryotic cell signaling and transcriptional activation induced by bacterial porins (2003) FEMS Microbiol. Lett., 226, pp. 57-64
Achouak, W., Heulin, T., Pages, J.M., Multiple facets of bacterial porins (2001) FEMS Microbiol. Lett., 199, pp. 1-7
Galdiero, F., Sommese, L., Scarfogliero, P., Galdiero, M., Biological activities-lethality, Shwartzman reaction and pyrogenicity of Salmonella typhimurium porins (1994) Microb. Pathog., 16, pp. 111-116
Vitiello, M., D'Isanto, M., Galdiero, M., Raieta, K., Tortora, A., Rotondo, P., Peluso, L., Galdiero, M., Interleukin-8 production by THP-1 cells stimulated by Salmonella enterica serovar Typhimurium porins is mediated by AP-1, NF-kappaB and MAPK pathways (2004) Cytokine, 27, pp. 15-24
Galdiero, M., Galdiero, M., Finamore, E., Rossano, F., Gambuzza, M., Catania, M.R., Teti, G., Mancuso, G., Haemophilus influenzae porin induces toll-like receptor 2-mediated cytokine production in human monocytes and mouse macrophages (2004) Infect. Immun., 72, pp. 1204-1209
Galdiero, M., D'Amico, M., Gorga, F., Di Filippo, C., D'Isanto, M., Vitiello, M., Longanella, A., Tortora, A., Haemophilus influenzae porin contributes to signaling of the inflammatory cascade in rat brain (2001) Infect. Immun., 69, pp. 221-227
Weiss, M.S., Schulz, G.E., Structure of porin refined at 1.8 A resolution (1992) J. Mol. Biol., 227, pp. 493-509
Koebnik, R., Locker, K.P., Van Gelder, P., Structure and function of bacterial outer membrane proteins: barrels in a nutshell (2000) Mol. Microbiol., 37, pp. 239-253
Galdiero, S., Capasso, D., Vitiello, M., D'Isanto, M., Pedone, C., Galdiero, M., Role of surface-exposed loops of Haemophilus influenzae protein P2 in the mitogen-activated protein kinase cascade (2003) Infect. Immun., 71, pp. 2798-2809
Galdiero, S., Vitiello, M., Amodeo, P., D'Isanto, M., Cantisani, M., Pedone, C., Galdiero, M., Structural requirements for proinflammatory activity of porin P2 loop 7 from Haemophilus influenzae (2006) Biochemistry, 45, pp. 4491-4501
Yi, K., Murphy, T.F., Importance of an immunodominant surface exposed loop on outer membrane protein P2 of nontypeable Haemophilus influenzae (1997) Infect. Immun., 65, pp. 150-155
Neary, J.M., Yi, K., Karalus, R.J., Murphy, T.F., Antibodies to loop 6 of the P2 porin protein of nontypeable Haemophilus influenzae are bactericidal against multiple strains (2001) Infect. Immun., 69, pp. 773-778
Sukumaran, S., Hauser, K., Maier, E., Benz, R., Mantele, W., Structure-function correlation of outer membrane protein porin from Paracoccus denitrificans (2006) Biopolymers, 82, pp. 344-348
Vincent, J.L., Sun, Q., Dubois, M.J., Clinical trials of immunomodulatory therapies in severe sepsis and septic shock (2002) Clin. Infect. Dis., 34, pp. 1084-1093
Opal, S.M., Gluck, T., Endotoxin as a drug target (2003) Crit. Care Med., 31, pp. 57-64
Boos, C.J., Goon, P.K., Lip, G.Y., The endothelium, inflammation, and coagulation in sepsis (2006) Clin. Pharmacol. Ther., 79, pp. 20-22
Lowe, G.D., The relationship between infection, inflammation, and cardiovascular disease: an overview (2001) Ann. Periodontol., 6, pp. 1-8
Aird, W.C., The role of the endothelium in severe sepsis and multiple organ dysfunction syndrome (2003) Blood, 101, pp. 3765-3777
Lowry, O.H., Rosebrough, N.J., Farr, A.L., Randall, R.J., Protein measurement with the Folin phenol reagent (1951) J. Biol. Chem., 193, pp. 265-275
Laemmli, U.K., Cleavage of structural proteins during the assembly of the head of bacteriophage T4 (1970) Nature, 277, pp. 680-685
Tsai, C.M., Frasch, C.E., A sensitive silver stain for detecting lipopolysaccharides in polyacrylamide gels (1982) Anal. Biochem., 119, pp. 115-119
Yin, E.T., Galanos, C., Kinsky, S., A Bradshaw, R., Wessler, S., Luderity, O., Sarmiento, M.F., Picogram-sensitive assay for endotoxin: gelation of Limulus polyphemus blood cell lysate induced by purified lipopolysaccharides and lipid A from Gram-negative bacteria (1972) Biochim. Biophys. Acta, 261, pp. 284-289
Issekutz, A.C., Removal of gram-negative endotoxin from solutions by affinity chromatography (1983) J. Immunol. Methods, 61, pp. 275-281
Hölm, S., A simple sequentially rejective multiple test procedure (1979) Scand. J. Statist., 6, pp. 65-70
Wang, Y.X., Dong, N., Wu, C., Martin-McNulty, B., Fitch, R.M., da Cunha, V., Vicelette, J., Wu, Q., Lipopolysaccharide attenuates thrombolysis in batroxobin-induced lung vasculature fibrin deposition but not in ferrous chloride-induced carotid artery thrombus in rats: role of endogenous PAI-1 (2003) Thromb. Res., 111, pp. 381-387
Kayal, S., Jais, J.P., Aguini, N., Chaudiere, J., Labrousse, J., Elevated circulating E-selectin, intercellular adhesion molecule 1, and von Willebrand factor in patients with severe infection (1998) Am. J. Respir. Crit. Care Med., 157, pp. 776-784
Schweda, E.K.H., Richards, J.C., Hood, D.W., Moxon, E.R., Expression and structural diversity of the lipopolysaccharide of Haemophilus influenzae: implication in virulence (2007) Int. J. Med. Microbiol., 297, pp. 297-306
Shen, K.P., Lo, Y.C., Yang, R.C., Liu, H.W., Chen, I.J., Wu, B.N., Antioxidanteugenosedin-A protects against lipopolysaccharide-induced hypotension, hyperglycaemia and cytokine immunoreactivity in rats and mice (2005) J. Pharm. Pharmacol., 57, pp. 117-125
Xia, Y., Krukoff, T.L., Cardiovascular responses to subseptic doses of endotoxin contribute to differential neuronal activation in rat brain (2001) Brain Res. Mol. Brain Res., 89, pp. 71-85
Galdiero, M., Folgore, A., Molitierno, M., Greco, R., Porins and lipopolysaccharide (LPS) from Salmonella typhimurium induce leucocyte transmigration through human endothelial cells in vitro (1999) Clin. Exp. Immunol., 116, pp. 453-461
Parrillo, J. E., Pathogenetic mechanisms of septic shock (1999) N. Engl. J. Med., 328, pp. 1471-147
Huntley, J. F., Conley, P. G., Hagman, K. E., Norgard, M. V., Characterization of Francisella tularensis outer membrane proteins (2007) J. Bacteriol., 189, pp. 561-574
Weiss, M. S., Schulz, G. E., Structure of porin refined at 1. 8 A resolution (1992) J. Mol. Biol., 227, pp. 493-509
Yi, K., Murphy, T. F., Importance of an immunodominant surface exposed loop on outer membrane protein P2 of nontypeable Haemophilus influenzae (1997) Infect. Immun., 65, pp. 150-155
Neary, J. M., Yi, K., Karalus, R. J., Murphy, T. F., Antibodies to loop 6 of the P2 porin protein of nontypeable Haemophilus influenzae are bactericidal against multiple strains (2001) Infect. Immun., 69, pp. 773-778
Vincent, J. L., Sun, Q., Dubois, M. J., Clinical trials of immunomodulatory therapies in severe sepsis and septic shock (2002) Clin. Infect. Dis., 34, pp. 1084-1093
Opal, S. M., Gluck, T., Endotoxin as a drug target (2003) Crit. Care Med., 31, pp. 57-64
Boos, C. J., Goon, P. K., Lip, G. Y., The endothelium, inflammation, and coagulation in sepsis (2006) Clin. Pharmacol. Ther., 79, pp. 20-22
Lowe, G. D., The relationship between infection, inflammation, and cardiovascular disease: an overview (2001) Ann. Periodontol., 6, pp. 1-8
Aird, W. C., The role of the endothelium in severe sepsis and multiple organ dysfunction syndrome (2003) Blood, 101, pp. 3765-3777
Lowry, O. H., Rosebrough, N. J., Farr, A. L., Randall, R. J., Protein measurement with the Folin phenol reagent (1951) J. Biol. Chem., 193, pp. 265-275
Laemmli, U. K., Cleavage of structural proteins during the assembly of the head of bacteriophage T4 (1970) Nature, 277, pp. 680-685
Tsai, C. M., Frasch, C. E., A sensitive silver stain for detecting lipopolysaccharides in polyacrylamide gels (1982) Anal. Biochem., 119, pp. 115-119
Yin, E. T., Galanos, C., Kinsky, S., A Bradshaw, R., Wessler, S., Luderity, O., Sarmiento, M. F., Picogram-sensitive assay for endotoxin: gelation of Limulus polyphemus blood cell lysate induced by purified lipopolysaccharides and lipid A from Gram-negative bacteria (1972) Biochim. Biophys. Acta, 261, pp. 284-289
Issekutz, A. C., Removal of gram-negative endotoxin from solutions by affinity chromatography (1983) J. Immunol. Methods, 61, pp. 275-281
H lm, S., A simple sequentially rejective multiple test procedure (1979) Scand. J. Statist., 6, pp. 65-70
Wang, Y. X., Dong, N., Wu, C., Martin-McNulty, B., Fitch, R. M., da Cunha, V., Vicelette, J., Wu, Q., Lipopolysaccharide attenuates thrombolysis in batroxobin-induced lung vasculature fibrin deposition but not in ferrous chloride-induced carotid artery thrombus in rats: role of endogenous PAI-1 (2003) Thromb. Res., 111, pp. 381-387
Schweda, E. K. H., Richards, J. C., Hood, D. W., Moxon, E. R., Expression and structural diversity of the lipopolysaccharide of Haemophilus influenzae: implication in virulence (2007) Int. J. Med. Microbiol., 297, pp. 297-306
Shen, K. P., Lo, Y. C., Yang, R. C., Liu, H. W., Chen, I. J., Wu, B. N., Antioxidanteugenosedin-A protects against lipopolysaccharide-induced hypotension, hyperglycaemia and cytokine immunoreactivity in rats and mice (2005) J. Pharm. Pharmacol., 57, pp. 117-125
Pathophysiological changes of gram-negative bacterial infection can be reproduced by a synthetic peptide mimicking loop L7 sequence of Haemophilus influenzae porin
Several in vivo models have been used to dissect the molecular mechanisms that contribute to activate the coagulation and fibrinolytic systems by bacteria and bacterial products but many aspects remain poorly understood. In this study we examined the in vivo effect of the synthetic peptide corresponding to loop L7 from Haemophilus influenzae type b (Hib) porin to evaluate its role on the coagulative/fibrinolytic cascade and the circulating markers of endothelial injury. Plasma was obtained from rats injected intravenously with loop L7, Hib porin or a scrambled peptide and tested for fragment 1+2 (F1+2), tissue-type plasminogen activator (tPA), plasminogen activator inhibitor type I (PAI-1) antigen, von Willebrand factor (vWF) and soluble E-selectin (sE-selectin). The coagulative/fibrinolytic cascade was impaired as shown by PAI-1 level increased. Concomitantly, E-selectin, a marker of endothelial injury, was also significantly elevated. In addition either loop L7 or Hib porin injection induced hyperglycaemia and inflammatory cytokine production. The data were correlated with hemodynamic functions. The results indicate that loop L7 plays an essential role in the pathophysiologic events observed during gram-negative infection. These findings may have implications for the development of alternative therapies to counteract excessive inflammatory responses during septic shock.
Several in vivo models have been used to dissect the molecular mechanisms that contribute to activate the coagulation and fibrinolytic systems by bacteria and bacterial products but many aspects remain poorly understood. In this study we examined the in vivo effect of the synthetic peptide corresponding to loop L7 from Haemophilus influenzae type b (Hib) porin to evaluate its role on the coagulative/fibrinolytic cascade and the circulating markers of endothelial injury. Plasma was obtained from rats injected intravenously with loop L7, Hib porin or a scrambled peptide and tested for fragment 1+2 (F1+2), tissue-type plasminogen activator (tPA), plasminogen activator inhibitor type I (PAI-1) antigen, von Willebrand factor (vWF) and soluble E-selectin (sE-selectin). The coagulative/fibrinolytic cascade was impaired as shown by PAI-1 level increased. Concomitantly, E-selectin, a marker of endothelial injury, was also significantly elevated. In addition either loop L7 or Hib porin injection induced hyperglycaemia and inflammatory cytokine production. The data were correlated with hemodynamic functions. The results indicate that loop L7 plays an essential role in the pathophysiologic events observed during gram-negative infection. These findings may have implications for the development of alternative therapies to counteract excessive inflammatory responses during septic shock.
Pathophysiological changes of gram-negative bacterial infection can be reproduced by a synthetic peptide mimicking loop L7 sequence of Haemophilus influenzae porin
Pathophysiological changes of gram-negative bacterial infection can be reproduced by a synthetic peptide mimicking loop L7 sequence of Haemophilus influenzae porin
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* Brain-gut-liver interactions across the spectrum of insulin resistance in metabolic fatty liver disease (36 views)
World J Gastroentero (ISSN: 1007-9327linking, 2219-2840), 2021 Aug 14; 27(30): 4999-5018.
Impact Factor: 3.665
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Troisi R, Balasco N, Santamaria A, Vitagliano L, Sica F
* Structural and functional analysis of the simultaneous binding of two duplex/quadruplex aptamers to human α-thrombin (26 views)
Int J Biol Macromol (ISSN: 0141-8130linking, 1879-0003electronic), 2021 Jun 30; 181: 858-867.
Impact Factor: 5.162
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Ngoc B, Vu Hoa T, N , Palumbo R, Rinaldo P, Fagoonee S, Phuc V
* Stem cell-derived exosomes for wound healing: current status and promising directions (61 views)
Minerva Med, 2021 Jun; 112(3): 384-400.
Impact Factor: 4.806
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Garello F, Boido M, Miglietti M, Bitonto V, Zenzola M, Filippi M, Arena F, Consolino L, Ghibaudi M, Terreno E
* Imaging of Inflammation in Spinal Cord Injury: Novel Insights on the Usage of PFC-Based Contrast Agents (18 views)
Biomedicines (ISSN: 2227-9059linking), 2021 Apr 3; 9(4): N/D-N/D.
Impact Factor: 4.757
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Coda AR, Anzilotti S, Boscia F, Greco A, Panico M, Gargiulo S, Gramanzini M, Zannetti A, Albanese S, Pignataro G, Annunziato L, Salvatore M, Brunetti A, De Berardinis P, Quarantelli M, Palma G, Pappata S
* In vivo imaging of CNS microglial activation/macrophage infiltration with combined [(18)F]DPA-714-PET and SPIO-MRI in a mouse model of relapsing remitting experimental autoimmune encephalomyelitis (149 views) (PDF 58 views)
Eur J Nucl Med (ISSN: 1619-7070linking, 1619-7089electronic, 1619-7070print), 2021 Jan; 48(1): 40-52.
Impact Factor: 7.18
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Rendina A, Drongitis D, Donizetti A, Fucci L, Milan G, Tripodi F, Giustezza F, Postiglione A, Pappata S, Ferrari R, Bossù P, Angiolillo A, Di Costanzo A, Caiazzo M, Vitale E
* CD33 and SIGLECL1 Immunoglobulin Superfamily Involved in Dementia (94 views)
J Neuropathol Exp Neurol (ISSN: 0022-3069linking), 2020 Jul 10; 79(8): 891-901.
Impact Factor: 3.51
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Negri R, Trinchese G, Carbone F, Caprio MG, Stanzione G, Di Scala C, Micillo T, Perna F, Tarotto L, Gelzo M, Cavaliere G, Spagnuolo MI, Corso G, Mattace Raso G, Matarese G, Mollica MP, Greco L, Iorio R
* Randomised Clinical Trial: Calorie Restriction Regimen with Tomato Juice Supplementation Ameliorates Oxidative Stress and Preserves a Proper Immune Surveillance Modulating Mitochondrial Bioenergetics of T-Lymphocytes in Obese Children Affected by Non-Alcoholic Fatty Liver Disease (NAFLD) (112 views) (PDF 85 views)
J Clin Med (ISSN: 2077-0383linking, 2077-0383electronic), 2020 Jan 4; 9(1): N/D-N/D.
Impact Factor: 5.688
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Actis GC, Pellicano R, Fagoonee S, Ribaldone DG
* History of Inflammatory Bowel Diseases (75 views)
J Clin Med (ISSN: 2077-0383linking, 2077-0383electronic), 2019 Nov 14; 8(11): N/D-N/D.
Impact Factor: 5.688
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Melillo E, Palmiero G, Ferro A, Mocavero PE, Monda V, Ascione L
* Diagnosis and Management of Left Atrium Appendage Thrombosis in Atrial Fibrillation Patients Undergoing Cardioversion (155 views)
Medicina (ISSN: 1010-660xlinking, 1648-9144electronic), 2019 Aug 21; 55(9): N/D-N/D.
Impact Factor: 1.467
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Perani D, Iaccarino L, Lammertsma AA, Windhorst AD, Edison P, Boellaard R, Hansson O, Nordberg A, Jacobs AH, Bottlaender M, Brooks D, Carroll MA, Chalon S, Gee A, Gerhard A, Halldin C, Herholz K, Herth MM, Hinz R, Knudsen GM, Kuhnast B, López-picón F, Moresco RM, Pappata S, Rinne JO, Rodriguez-vieitez E, Santiago-ribeiro MJ, Turkheimer FE, Van Laere K, Varrone A, Vercouillie J, Winkeler A
* A new perspective for advanced positron emission tomography-based molecular imaging in neurodegenerative proteinopathies (206 views)
Alzheimers Dement (ISSN: 1552-5260linking), 2019 Jun 20; N/D: N/D-N/D.
Impact Factor: 14.43
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Perani D, Iaccarino L, Jacobs AH, Lammertsma AA, Nordberg A, Windhorst AD, Gerhard A, Winkeler A, Jacobs AH, Gee A, Kuhnast B, Halldin C, Perani D, Brooks D, Rodriguez-vieitez E, Turkheimer FE, López-picón F, Knudsen GM, Vercouillie J, Rinne JO, Herholz K, Van Laere K, Santiago-ribeiro MJ, Herth MM, Carroll MA, Bottlaender M, Hansson O, Edison P, Hinz R, Boellaard R, Moresco RM, Pappata S
* Application of advanced brain positron emission tomography-based molecular imaging for a biological framework in neurodegenerative proteinopathies (253 views)
Alzheimers Dement (ISSN: 2352-8729print), 2019 Apr 16; 11: 327-332.
Impact Factor: 14.423
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Parisi V, Petraglia L, D'Esposito V, Cabaro S, Rengo G, Caruso A, Grimaldi MG, Baldascino F, De Bellis A, Vitale D, Formisano R, Ferro A, Paolillo S, Davin L, Lancellotti P, Formisano P, Perrone Filardi P, Ferrara N, Leosco D
* Statin therapy modulates thickness and inflammatory profile of human epicardial adipose tissue (293 views)
Int J Cardiol (ISSN: 0167-5273, 1874-1754electronic, 0167-5273linking), 2019 Jan 1; 274: 326-330.
Impact Factor: 3.121
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Ugga L, Romeo V, Tedeschi E, Brunetti A, Quarantelli M
* Superparamagnetic iron oxide nanocolloids in MRI studies of neuroinflammation (364 views)
J Neurosci Methods (ISSN: 0165-0270linking, 1872-678xelectronic), 2018 Jun 18; 310: 12-23.
Impact Factor: 2.668
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Meli R, Pirozzi C, Pelagalli A
* New Perspectives on the Potential Role of Aquaporins (AQPs) in the Physiology of Inflammation (260 views)
Front Physiol (ISSN: 1664-042xprint, 1664-042xlinking), 2018 Feb 16; 9(FEB): 101-101.
Impact Factor: 4.134
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Garello F, Pagoto A, Arena F, Buffo A, Blasi F, Alberti D, Terreno E
* MRI visualization of neuroinflammation using VCAM-1 targeted paramagnetic micelles (231 views)
Nanomedicine (ISSN: 1549-9634, 1549-9642), 2017 Nov 8; N/D: N/D-N/D.
Impact Factor: 6.5
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Pontillo G, Cocozza S, Lanzillo R, Borrelli P, De Rosa A, Brescia Morra V, Tedeschi E, PalmaG
* Brain Susceptibility Changes in a Patient with Natalizumab-Related Progressive Multifocal Leukoencephalopathy: A Longitudinal Quantitative Susceptibility Mapping and Relaxometry Study (232 views)
Front Neurol (ISSN: 1664-2295, 1664-2295linking, 1664-2295print), 2017 Jun 19; 8: 294-294.
Impact Factor: 3.508
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Dennehy R, RomanoM, Ruggiero A, Mohamed YF, Dignam SL, Mujica Troncoso C, Callaghan M, Valvano MA, Berisio R, Mcclean S
* The Burkholderia cenocepacia peptidoglycan-associated lipoprotein is involved in epithelial cell attachment and elicitation of inflammation (292 views)
Cell Microbiol (ISSN: 1462-5814), 2017 May; 19(5): e12691-e12691.
Impact Factor: 4.41
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Gargiulo S, Coda AR, Panico M, Gramanzini M, Moresco RM, Chalon S, Pappata S
* Molecular imaging of neuroinflammation in preclinical rodent models using positron emission tomography (307 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1827-1936), 2017 Mar; 61(1): 60-75.
Impact Factor: 2.368
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Auletta L, Greco A, Albanese S, Meomartino L, Salvatore M, Mancini M
* Original Research: Feasibility and safety of two surgical techniques for the development of an animal model of jugular vein occlusion (451 views)
Exp Biol Med (ISSN: 1535-3699electronic, 1535-3699linking), 2017 Jan; 242(1): 22-28.
Impact Factor: 2.542
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Bozzetto L, Annuzzi G, Ragucci M, Di Donato O, Della Pepa G, Della Corte G, Griffo E, Anniballi G, Giacco A, Mancini M, Rivellese AA
* Insulin resistance, postprandial GLP-1 and adaptive immunity are the main predictors of NAFLD in a homogeneous population at high cardiovascular risk (265 views)
Nutrition (ISSN: 0939-4753, 1590-3729electronic), 2016 Jul; 26(7): 623-629.
Impact Factor: 3.679
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Vetrani C, Costabile G, Luongo D, Naviglio D, Rivellese AA, Riccardi G, Giacco R
* Effects of whole-grain cereal foods on plasma short chain fatty acid concentrations in individuals with the metabolic syndrome (312 views)
Nutrition (ISSN: 0899-9007), 2016 Feb; 32(2): 217-221.
Impact Factor: 3.42
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Pane K, Sgambati V, Zanfardino A, Smaldone G, Cafaro V, Angrisano T, Pedone E, Di Gaetano S, Capasso D, Haney EF, Izzo V, Varcamonti M, Notomista E, Hancock RE, Di Donato A, Pizzo E
* A new cryptic cationic antimicrobial peptide from human apolipoprotein E with antibacterial activity and immunomodulatory effects on human cells (426 views)
Febs J (ISSN: 1742-464x), 2016; N/D: N/D-N/D.
Impact Factor: 3.902
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Kim YH, Shin SW, Pellicano R, Fagoonee S, Choi IJ, Kim YI, Park B, Choi JM, Kim SG, Choi J, Park JY, Oh S, Yang HJ, Lim JH, Im JP, Kim JS, Jung HC, Ponzetto A, Figura N, Malfertheiner P, Choi IJ, Kook MC, Kim YI, Cho SJ, Lee JY, Kim CG, Park B, Nam BH, Bae SE, Choi KD, Choe J, Kim SO, Na HK, Choi JY, Ahn JY, Jung KW, Lee J, Kim DH, Chang HS, Song HJ, Lee GH, Jung HY, Seta T, Takahashi Y, Noguchi Y, Shikata S, Sakai T, Sakai K, Yamashita Y, Nakayama T, Leja M, Park JY, Murillo R, Liepniece-karele I, Isajevs S, Kikuste I, Rudzite D, Krike P, Parshutin S, Polaka I, Kirsners A, Santare D, Folkmanis V, Daugule I, Plummer M, Herrero R, Tsukamoto T, Nakagawa M, Kiriyama Y, Toyoda T, Cao X, Corral JE, Mera R, Dye CW, Morgan DR, Lee YC, Lin JT, Garcia Martin R, Matia Cubillo A, Lee SH, Park JM, Han YM, Ko WJ, Hahm KB, Leontiadis GI, Ford AC, Ichinose M, Sugano K, Jeong M, Park JM, Han YM, Park KY, Lee DH, Yoo JH, Cho JY, Hahm KB, Bang CS, Baik GH, Shin IS, Kim JB, Suk KT, Yoon JH, Kim YS, Kim DJ
* Helicobacter pylori Eradication for Prevention of Metachronous Recurrence after Endoscopic Resection of Early Gastric Cancer (297 views)
N Engl J Med (ISSN: 0028-4793, 0028-4793linking, 1533-4406electronic), 2015 Jun; 30642104201566393291: 749-756.
Impact Factor: 59.558
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Vicidomini C, Panico M, Greco A, Gargiulo S, Coda ARD, Zannetti A, Gramanzini M, Roviello GN, Quarantelli M, Alfano B, Tavitian B, Dolle F, Salvatore M, Brunetti A, Pappata S
* In vivo imaging and characterization of [(18)F]DPA-714, a potential new TSPO ligand, in mouse brain and peripheral tissues using small-animal PET (732 views) (PDF 263 views)
Nucl Med Biol (ISSN: 0969-8051, 0883-2897), 2015 Mar; 42(3): 309-316.
Impact Factor: 2.429
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Klauzinska M, Bertolette D, Tippireddy S, Strizzi L, Gray PC, Gonzales M, Duroux M, Ruvo M, Wechselberger C, Castro NP, Rangel MC, Focà A, Sandomenico A, Hendrix MJC, Salomon D, Cuttitta F
* Cripto-1: an extracellular protein – connecting the sequestered biological dots (296 views)
Connect Tissue Res (ISSN: 0300-8207), 2015; N/D: N/D-N/D.
Impact Factor: 1.411
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Quarantelli M
* MRI/MRS in neuroinflammation: methodology and applications (296 views)
Clin Transl Imaging (ISSN: 2281-5872print, 2281-5872linking), 2015; 3: 475-489.
Impact Factor: 0
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Di Lorenzo F, Silipo A, Bianconi I, Lore' NI, Scamporrino A, Sturiale L, Garozzo D, Lanzetta R, Parrilli M, Bragonzi A, Molinaro A
* Persistent cystic fibrosis isolate Pseudomonas aeruginosa strain RP73 exhibits an under-acylated LPS structure responsible of its low inflammatory activity (363 views)
Mol Immunol (ISSN: 0161-5890), 2015; 63(2): 166-175.
Impact Factor: 3.375
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Gargiulo S, Petretta MP, Greco A, Panico M, Larobina M, Gramanzini M, Schiattarella GG, Esposito G, Petretta M, Brunetti A, Cuocolo A
* Genetic deletion in uncoupling protein 3 augments 18F-fluorodeoxyglucose cardiac uptake in the ischemic heart (434 views)
Bmc Cardiovasc Disor (ISSN: 1471-2261), 2014 Sep 8; 14(1): 98-98.
Impact Factor: 1.878
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Musumeci D, Roviello GN, Montesarchio D
* An overview on HMGB1 inhibitors as potential therapeutic agents in HMGB1-related pathologies (555 views)
Pharmacol Ther (ISSN: 0163-7258, 0163-7258linking), 2014 Mar; 141(3): 347-357.
Impact Factor: 9.723
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Vitale M, Luongo D, Naviglio D, Bozzetto L, Mirabella M, Rivieccio AM, Giacco A, Rivellese AA
* Trans fatty acids consumption in type 1 diabetic patients: evaluation by dietary records and measurement in serum phospholipids (388 views)
Acta Diabetol (ISSN: 0940-5429, 1432-5233electronic), 2013 Aug; 50(4): 651-654.
Impact Factor: 3.679
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Madonna S, Scarponi C, Doti N, Carbone T, Cavani A, Scognamiglio PL, Marasco D, Albanesi C
* Therapeutical potential of a peptide mimicking the SOCS1 kinase inhibitory region in skin immune responses (584 views)
Eur J Immunol (ISSN: 0014-2980), 2013 Jul; 43(7): 1883-1895.
Impact Factor: 4.518
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Lombardo B, Rocco T, Esposito MT, Cantilena B, Gargiulo S, Greco A, Montanaro D, Brunetti A, Pastore L
* Thymidine Kinase-Mediated Shut Down of Bone Morphogenetic Protein-4 Expression Allows Regulated Bone Production (350 views)
Current Gene Therapy (ISSN: 1566-5232, 1875-5631), 2013 Jun 1; 13(3): 202-210.
Impact Factor: 4.906
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Castiglione F, Mainenti PP, De Palma GD, Testa A, Bucci L, Pesce G, Camera L, Diaferia M, Rea M, Caporaso N, Salvatore M, Rispo A
* Noninvasive diagnosis of small bowel crohn's disease: Direct comparison of bowel sonography and magnetic resonance enterography (471 views)
Inflamm Bowel Dis (ISSN: 1078-0998, 1536-4844electronic, 1078-0998linking), 2013 Apr; 19(4): 991-998.
Impact Factor: 5.475
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Greco A, Fiumara G, Gargiulo S, Gramanzini M, Brunetti A, Cuocolo A
* High-resolution positron emission tomography/computed tomography imaging of the mouse heart (466 views)
Exp Physiol Experimental Physiology (ISSN: 1469-445x, 0958-0670), 2013 Mar; 98(3): 645-651.
Impact Factor: 2.871
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Ciccarelli M, Sorriento D, Franco A, Fusco A, Del Giudice C, Annunziata R, Cipolletta E, Monti MG, Dorn GW, Trimarco B, Iaccarino G
* Endothelial G protein-coupled receptor kinase 2 regulates vascular homeostasis through the control of free radical oxygen species (461 views)
Arterioscler Thromb Vasc Biol Arteriosclerosis Thrombosis And Vascular Biology (ISSN: 1079-5642, 1049-8834), 2013; 33(10): 2415-2424.
Impact Factor: 5.533
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Sorriento D, Fusco A, Ciccarelli M, Rungi A, Anastasio A, Carillo A, Dorn II GW, Trimarco B, Iaccarino G
* Mitochondrial G protein coupled receptor kinase 2 regulates proinflammatory responses in macrophages (385 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 2013; 587(21): 3487-3494.
Impact Factor: 3.341
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Dolga AM, Letsche T, Gold M, Doti N, Bacher M, Chiamvimonvat N, Dodel R, Culmsee C
* Activation of KCNN3/SK3/K(Ca)2. 3 channels attenuates enhanced calcium influx and inflammatory cytokine production in activated microglia (552 views)
Glia (ISSN: 1098-1136), 2012 Dec; 60(12): 2050-2064.
Impact Factor: 5.466
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Berisio R
* Learning from pathogens: Exploiting host-pathogen liaison for therapeutic development (508 views)
Curr Protein Pept Sci (ISSN: 1389-2037, 1389-2037linking), 2012 Dec; 13(8): 697-698.
Impact Factor: 2.326
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Fusari M, Sorrentino N, Bottazzi EC, Del Vecchio W, Cozzolino I, Maurea S, Salvatore M, Imbriaco M
* Primary signet ring cell carcinoma of the appendix mimicking acute appendicitis (208 views)
Acta Radiologica Short Reports (ISSN: 2047-9816), 2012 Oct 5; 1(9): 2012-2012.
Impact Factor: 1.35
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Jacobs AH, Tavitian B, TheInmindG, Pappata S, Quarantelli M
* Noninvasive molecular imaging of neuroinflammation (335 views) (PDF 196 views)
J Cereb Blood Flow Metab (ISSN: 0271-678x, 1559-7016electronic), 2012 Jul; 32(7): 1393-1415.
Impact Factor: 5.398
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Pier PM
* RE: Imaging Features of Hepato-Splenic Amyloidosis at PET/CT (293 views)
Korean Journal Of Radiology (ISSN: 1229-6929), 2012 May; 13(3): 368-369.
Impact Factor: 1.555
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Vitiello M, Galdiero M, Finamore E, Galdiero S, Galdiero M
* NF-κB as a potential therapeutic target in microbial diseases (484 views)
Mol Biosyst (ISSN: 1742-206x), 2012; 8(4): 1108-1120.
Impact Factor: 3.35
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Gargiulo S, Greco A, Gramanzini M, Petretta MP, Ferro A, Larobina M, Panico M, Brunetti A, Cuocolo A
* PET/CT imaging in mouse models of myocardial ischemia (666 views)
J Biomed Biotechnol (ISSN: 1110-7251, 1110-7243), 2012; 2012: 541872-541872.
Impact Factor: 2.88
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Di Paola R, Impellizzeri D, Salinaro AT, Mazzon E, Bellia F, Cavallaro M, Cornelius C, Vecchio G, Calabrese V, Rizzarelli E, Cuzzocrea S
* Administration of carnosine in the treatment of acute spinal cord injury (604 views)
Biochem Pharmacol Biochemical Pharmacology (ISSN: 1873-2968, 0006-2952), 2011 Nov 15; 82(10): 1478-1489.
Impact Factor: 4.705
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Cuocolo A
Current research in nuclear medicine and molecular imaging in Italy: Highlights of the 10th National Congress of the Italian Association of Nuclear Medicine and Molecular Imaging (463 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2011 Jun; 55(3): 280-300.
Impact Factor: 1.724
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Acampa W, Di Taranto MD, Morgante A, Salvatore B, Evangelista L, Ricci F, Costanzo P, De Sisto E, Filardi PP, Petretta M, Fortunato G, Cuocolo A
* C-reactive protein levels are associated with paraoxonase polymorphism L55M in patients undergoing cardiac SPECT imaging (377 views)
Scand J Clin Lab Invest (ISSN: 0036-5513, 1502-7686), 2011 May; 71(3): 179-184.
Impact Factor: 1.156
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Rossi FF, Pedone C, Antonelli Incalzi R
Chronic obstructive pulmonary disease and cardiovascular disease: role of the systemic inflammation (445 views)
Recenti Prog Med (ISSN: 0034-1193, 0034-1193print), 2011 Mar; 102(3): 109-113.
Impact Factor: 0.318
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Severino V, Chambery A, Vitiello M, Cantisani M, Galdiero S, Galdiero M, Malorni L, Di Maro A, Parente A
* Proteomic Analysis of Human U937 Cell Line Activation Mediated by Haemophilus influenzae Type b P2 Porin and Its Surface-Exposed Loop (460 views)
J Proteome Res (ISSN: 1535-3893), 2010 Feb; 9(2): 1050-1062.
Impact Factor: 5.46
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Cigliano L, Pugliese CR, Spagnuolo MS, Palumbo R, Abrescia P
* Haptoglobin binds the antiatherogenic protein apolipoprotein e - Impairment of apolipoprotein e stimulation of both lecithin: Cholesterol acyltransferase activity and cholesterol uptake by hepatocytes (396 views)
Febs J (ISSN: 1742-464x), 2009 Nov; 276(21): 6158-6171.
Impact Factor: 3.042
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Vergote J, Chalon S, Emond P, Vercouillie J, Pappata S, Guilloteau D
* New SPECT and PET dementia tracers (358 views)
Med Nucl (ISSN: 0928-1258), 2009 Mar; 33(3): 137-141.
Impact Factor: 0.155
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Sorriento D, Campanile A, Santulli G, Leggiero E, Pastore L, Trimarco B, Iaccarino G
* A new synthetic protein, TAT-RH, inhibits tumor growth through the regulation of NFκB activity (358 views)
Mol Cancermolecular Cancer (ISSN: 1476-4598), 2009; 8: N/D-N/D.
Impact Factor: 4.16
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Chiechio S, Zammataro M, Morales ME, Busceti CL, Drago F, Th Gereau RW, Copani A, Nicoletti F
* Epigenetic modulation of mGlu2 receptors by histone deacetylase inhibitors in the treatment of inflammatory pain (497 views)
Mol Pharmacol (ISSN: 0026-895x), 2009; 75(5): 1014-1020.
Impact Factor: 4.531
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Sorriento D, Ciccarelli M, Santulli G, Campanile A, Altobelli GG, Cimini V, Galasso G, Astone D, Piscione F, Pastore L, Trimarco B, Iaccarino G
* The G-protein-coupled receptor kinase 5 inhibits NFκB transcriptional activity by inducing nuclear accumulation of IκBα (438 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2008; 105(46): 17818-17823.
Impact Factor: 9.38
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Martinelli P, Maruotti GM, Oppedisano R, Agangi A, Mazzarelli LL, Votino C, Quarantelli M, Iaccarino V
* Is uterine artery embolization for cervical ectopic pregnancy always safe? (320 views)
J Minimally Invasive Gynecol (ISSN: 1553-4650), 2007 Nov; 14(6): 758-763.
Impact Factor: 1.607
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Salvatore A, Cigliano L, Bucci EM, Corpillo D, Velasco S, Carlucci A, Pedone C, Abrescia P
* Haptoglobin binding to apolipoprotein A-I prevents damage from hydroxyl radicals on its stimulatory activity of the enzyme lecithin-cholesterol acyl-transferase (407 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2007 Oct 2; 46(39): 11158-11168.
Impact Factor: 3.368
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Cuzzocrea S, Genovese T, Failla M, Vecchio G, Fruciano M, Mazzon E, Di Paola R, Muià C, La Rosa C, Crimi N, Rizzarelli E, Vancheri C
* Protective effect of orally administered carnosine on bleomycin-induced lung injury (575 views)
Am J Physiol Lung Cell Mol Physiol (ISSN: 1040-0605), 2007 May; 292(5): L1095-L1095.
Impact Factor: 4.214
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Musumeci D, Roviello GN, Moccia M, Pedone C, Bucci EM, Sapio R, Valente M, Fumero S
* Bent oligonucleotide duplexes as HMGB1 inhibitors: A comparative study (348 views)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1525-7770), 2007; 26(10-12): 1447-1450.
Impact Factor: 0.723
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Bucci EM, Valente M, Musumeci D, Sapio R, Anrò V, Roviello GN, Moccia M
* ODN-based drugs for targeting of extracellular proteins (284 views)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1525-7770), 2007; 26(8-9): 1047-1050.
Impact Factor: 0.723
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Galdiero S, Vitiello M, Amodeo P, D'Isanto M, Cantisani M, Pedone C, Galdiero M
* Structural requirements for proinflammatory activity of porin P2 loop 7 from Haemophilus influenzae (514 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2006 Apr 11; 45(14): 4491-4501.
Impact Factor: 3.633
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Cuocolo A, Acampa W, Varrone A, Salvatore M
* Highlights of the Annual Congress of the European Association of Nuclear Medicine, Istanbul, 2005: The incremental value of nuclear medicine for patient management and care (584 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2006 Mar; 33(3): 360-381.
Impact Factor: 4.041
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Marino M, Rossi M, Ruvo M, Fassina G
* Novel molecular targets for systemic lupus erythematosus (369 views)
Curr Drug Targets (ISSN: 1389-4501), 2002 Jun; 3(3): 223-228.
Impact Factor: 3.597
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Lombardi A, De Simone G, Galdiero S, Staiano N, Nastri F, Pavone V
From natural to synthetic multisite thrombin inhibitors (349 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1999; 51(1): 19-39.
Impact Factor: 2.331
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Lombardi A, D'Agostino B, Filippelli A, Pedone C, Matera MG, Falciani M, De Rosa M, Rossi F, Pavone V
Neuronorm is a potent and water soluble neurokinin A receptor antagonist (387 views)
Bioorganic & Medicinal Chemistry Letters (ISSN: 0960-894x), 1998 Jul 7; 8(13): 1735-1740.
Impact Factor: 1.5
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Testino G, Leone S, Fagoonee S, Del Bas JM, Rodriguez B, Puiggros F, Marine S, Rodriguez MA, Morina D, Armengol L, Caimari A, Arola L, Cimini FA, Barchetta I, Carotti S, Bertoccini L, Baroni MG, Vespasiani-gentilucci U, Cavallo MG, Morini S, Nelson JE, Roth CL, Wilson LA, Yates KP, Aouizerat B, Morgan-stevenson V, Whalen E, Hoofnagle A, Mason M, Gersuk V, Yeh MM, Kowdley KV, Lee SM, Jun DW, Cho YK, Jang KS, Kucukazman M, Ata N, Dal K, Yeniova AO, Kefeli A, Basyigit S, Aktas B, Akin KO, Agladioglu K, Ure OS, Topal F, Nazligul Y, Beyan E, Ertugrul DT, Catena C, Cosma C, Camozzi V, Plebani M, Ermani M, Sechi LA, Fallo F, Goto Y, Ray MB, Mendenhall CL, French SW, Gartside PS
Serum vitamin A deficiency and increased intrahepatic expression of cytokeratin antigen in alcoholic liver disease (600 views)
Hepatology (ISSN: 1827-1669electronic, 0026-4806linking), 1988 Sep; 83120693611123109(5): 1019-1026.
Impact Factor: 0.913
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* Evidence of a Gastro-Duodenal Effect on Adipose Tissue and Brain Metabolism, Potentially Mediated by Gut–Liver Inflammation: A Study with Positron Emission Tomography and Oral 18FDG in Mice (9 views)
Int J Mol Sci (ISSN: 1422-0067electronic), 2022 Feb 28; 23 (5 ): N/D-N/D.
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La Manna S, Lopez-sanz L, Bernal S, Fortuna S, Mercurio FA, Leone M, Gomez-guerrero C, Marasco D
* Cyclic mimetics of kinase-inhibitory region of Suppressors of Cytokine Signaling 1: Progress toward novel anti-inflammatory therapeutics (22 views)
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Impact Factor: 5.572
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Guzzardi MA, La Rosa F, Campani D, Cacciato Insilla A, De Sena V, Panetta D, Brunetto MR, Bonino F, Collado MC, Iozzo P
* Maturation of the Visceral (Gut-Adipose-Liver) Network in Response to the Weaning Reaction versus Adult Age and Impact of Maternal High-Fat Diet (8 views)
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Rebelos E, Iozzo P, Guzzardi MA, Brunetto MR, Bonino F
* Brain-gut-liver interactions across the spectrum of insulin resistance in metabolic fatty liver disease (36 views)
World J Gastroentero (ISSN: 1007-9327linking, 2219-2840), 2021 Aug 14; 27(30): 4999-5018.
Impact Factor: 3.665
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Troisi R, Balasco N, Santamaria A, Vitagliano L, Sica F
* Structural and functional analysis of the simultaneous binding of two duplex/quadruplex aptamers to human α-thrombin (26 views)
Int J Biol Macromol (ISSN: 0141-8130linking, 1879-0003electronic), 2021 Jun 30; 181: 858-867.
Impact Factor: 5.162
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Ngoc B, Vu Hoa T, N , Palumbo R, Rinaldo P, Fagoonee S, Phuc V
* Stem cell-derived exosomes for wound healing: current status and promising directions (61 views)
Minerva Med, 2021 Jun; 112(3): 384-400.
Impact Factor: 4.806
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Garello F, Boido M, Miglietti M, Bitonto V, Zenzola M, Filippi M, Arena F, Consolino L, Ghibaudi M, Terreno E
* Imaging of Inflammation in Spinal Cord Injury: Novel Insights on the Usage of PFC-Based Contrast Agents (18 views)
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Impact Factor: 4.757
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Coda AR, Anzilotti S, Boscia F, Greco A, Panico M, Gargiulo S, Gramanzini M, Zannetti A, Albanese S, Pignataro G, Annunziato L, Salvatore M, Brunetti A, De Berardinis P, Quarantelli M, Palma G, Pappata S
* In vivo imaging of CNS microglial activation/macrophage infiltration with combined [(18)F]DPA-714-PET and SPIO-MRI in a mouse model of relapsing remitting experimental autoimmune encephalomyelitis (149 views) (PDF 58 views)
Eur J Nucl Med (ISSN: 1619-7070linking, 1619-7089electronic, 1619-7070print), 2021 Jan; 48(1): 40-52.
Impact Factor: 7.18
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Rendina A, Drongitis D, Donizetti A, Fucci L, Milan G, Tripodi F, Giustezza F, Postiglione A, Pappata S, Ferrari R, Bossù P, Angiolillo A, Di Costanzo A, Caiazzo M, Vitale E
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J Neuropathol Exp Neurol (ISSN: 0022-3069linking), 2020 Jul 10; 79(8): 891-901.
Impact Factor: 3.51
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Negri R, Trinchese G, Carbone F, Caprio MG, Stanzione G, Di Scala C, Micillo T, Perna F, Tarotto L, Gelzo M, Cavaliere G, Spagnuolo MI, Corso G, Mattace Raso G, Matarese G, Mollica MP, Greco L, Iorio R
* Randomised Clinical Trial: Calorie Restriction Regimen with Tomato Juice Supplementation Ameliorates Oxidative Stress and Preserves a Proper Immune Surveillance Modulating Mitochondrial Bioenergetics of T-Lymphocytes in Obese Children Affected by Non-Alcoholic Fatty Liver Disease (NAFLD) (112 views) (PDF 85 views)
J Clin Med (ISSN: 2077-0383linking, 2077-0383electronic), 2020 Jan 4; 9(1): N/D-N/D.
Impact Factor: 5.688
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Actis GC, Pellicano R, Fagoonee S, Ribaldone DG
* History of Inflammatory Bowel Diseases (75 views)
J Clin Med (ISSN: 2077-0383linking, 2077-0383electronic), 2019 Nov 14; 8(11): N/D-N/D.
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Melillo E, Palmiero G, Ferro A, Mocavero PE, Monda V, Ascione L
* Diagnosis and Management of Left Atrium Appendage Thrombosis in Atrial Fibrillation Patients Undergoing Cardioversion (155 views)
Medicina (ISSN: 1010-660xlinking, 1648-9144electronic), 2019 Aug 21; 55(9): N/D-N/D.
Impact Factor: 1.467
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Perani D, Iaccarino L, Lammertsma AA, Windhorst AD, Edison P, Boellaard R, Hansson O, Nordberg A, Jacobs AH, Bottlaender M, Brooks D, Carroll MA, Chalon S, Gee A, Gerhard A, Halldin C, Herholz K, Herth MM, Hinz R, Knudsen GM, Kuhnast B, López-picón F, Moresco RM, Pappata S, Rinne JO, Rodriguez-vieitez E, Santiago-ribeiro MJ, Turkheimer FE, Van Laere K, Varrone A, Vercouillie J, Winkeler A
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Alzheimers Dement (ISSN: 1552-5260linking), 2019 Jun 20; N/D: N/D-N/D.
Impact Factor: 14.43
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Perani D, Iaccarino L, Jacobs AH, Lammertsma AA, Nordberg A, Windhorst AD, Gerhard A, Winkeler A, Jacobs AH, Gee A, Kuhnast B, Halldin C, Perani D, Brooks D, Rodriguez-vieitez E, Turkheimer FE, López-picón F, Knudsen GM, Vercouillie J, Rinne JO, Herholz K, Van Laere K, Santiago-ribeiro MJ, Herth MM, Carroll MA, Bottlaender M, Hansson O, Edison P, Hinz R, Boellaard R, Moresco RM, Pappata S
* Application of advanced brain positron emission tomography-based molecular imaging for a biological framework in neurodegenerative proteinopathies (253 views)
Alzheimers Dement (ISSN: 2352-8729print), 2019 Apr 16; 11: 327-332.
Impact Factor: 14.423
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Parisi V, Petraglia L, D'Esposito V, Cabaro S, Rengo G, Caruso A, Grimaldi MG, Baldascino F, De Bellis A, Vitale D, Formisano R, Ferro A, Paolillo S, Davin L, Lancellotti P, Formisano P, Perrone Filardi P, Ferrara N, Leosco D
* Statin therapy modulates thickness and inflammatory profile of human epicardial adipose tissue (293 views)
Int J Cardiol (ISSN: 0167-5273, 1874-1754electronic, 0167-5273linking), 2019 Jan 1; 274: 326-330.
Impact Factor: 3.121
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Ugga L, Romeo V, Tedeschi E, Brunetti A, Quarantelli M
* Superparamagnetic iron oxide nanocolloids in MRI studies of neuroinflammation (364 views)
J Neurosci Methods (ISSN: 0165-0270linking, 1872-678xelectronic), 2018 Jun 18; 310: 12-23.
Impact Factor: 2.668
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Meli R, Pirozzi C, Pelagalli A
* New Perspectives on the Potential Role of Aquaporins (AQPs) in the Physiology of Inflammation (260 views)
Front Physiol (ISSN: 1664-042xprint, 1664-042xlinking), 2018 Feb 16; 9(FEB): 101-101.
Impact Factor: 4.134
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Garello F, Pagoto A, Arena F, Buffo A, Blasi F, Alberti D, Terreno E
* MRI visualization of neuroinflammation using VCAM-1 targeted paramagnetic micelles (231 views)
Nanomedicine (ISSN: 1549-9634, 1549-9642), 2017 Nov 8; N/D: N/D-N/D.
Impact Factor: 6.5
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Pontillo G, Cocozza S, Lanzillo R, Borrelli P, De Rosa A, Brescia Morra V, Tedeschi E, PalmaG
* Brain Susceptibility Changes in a Patient with Natalizumab-Related Progressive Multifocal Leukoencephalopathy: A Longitudinal Quantitative Susceptibility Mapping and Relaxometry Study (232 views)
Front Neurol (ISSN: 1664-2295, 1664-2295linking, 1664-2295print), 2017 Jun 19; 8: 294-294.
Impact Factor: 3.508
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Dennehy R, RomanoM, Ruggiero A, Mohamed YF, Dignam SL, Mujica Troncoso C, Callaghan M, Valvano MA, Berisio R, Mcclean S
* The Burkholderia cenocepacia peptidoglycan-associated lipoprotein is involved in epithelial cell attachment and elicitation of inflammation (292 views)
Cell Microbiol (ISSN: 1462-5814), 2017 May; 19(5): e12691-e12691.
Impact Factor: 4.41
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Gargiulo S, Coda AR, Panico M, Gramanzini M, Moresco RM, Chalon S, Pappata S
* Molecular imaging of neuroinflammation in preclinical rodent models using positron emission tomography (307 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1827-1936), 2017 Mar; 61(1): 60-75.
Impact Factor: 2.368
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Auletta L, Greco A, Albanese S, Meomartino L, Salvatore M, Mancini M
* Original Research: Feasibility and safety of two surgical techniques for the development of an animal model of jugular vein occlusion (451 views)
Exp Biol Med (ISSN: 1535-3699electronic, 1535-3699linking), 2017 Jan; 242(1): 22-28.
Impact Factor: 2.542
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Bozzetto L, Annuzzi G, Ragucci M, Di Donato O, Della Pepa G, Della Corte G, Griffo E, Anniballi G, Giacco A, Mancini M, Rivellese AA
* Insulin resistance, postprandial GLP-1 and adaptive immunity are the main predictors of NAFLD in a homogeneous population at high cardiovascular risk (265 views)
Nutrition (ISSN: 0939-4753, 1590-3729electronic), 2016 Jul; 26(7): 623-629.
Impact Factor: 3.679
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Vetrani C, Costabile G, Luongo D, Naviglio D, Rivellese AA, Riccardi G, Giacco R
* Effects of whole-grain cereal foods on plasma short chain fatty acid concentrations in individuals with the metabolic syndrome (312 views)
Nutrition (ISSN: 0899-9007), 2016 Feb; 32(2): 217-221.
Impact Factor: 3.42
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Pane K, Sgambati V, Zanfardino A, Smaldone G, Cafaro V, Angrisano T, Pedone E, Di Gaetano S, Capasso D, Haney EF, Izzo V, Varcamonti M, Notomista E, Hancock RE, Di Donato A, Pizzo E
* A new cryptic cationic antimicrobial peptide from human apolipoprotein E with antibacterial activity and immunomodulatory effects on human cells (426 views)
Febs J (ISSN: 1742-464x), 2016; N/D: N/D-N/D.
Impact Factor: 3.902
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Kim YH, Shin SW, Pellicano R, Fagoonee S, Choi IJ, Kim YI, Park B, Choi JM, Kim SG, Choi J, Park JY, Oh S, Yang HJ, Lim JH, Im JP, Kim JS, Jung HC, Ponzetto A, Figura N, Malfertheiner P, Choi IJ, Kook MC, Kim YI, Cho SJ, Lee JY, Kim CG, Park B, Nam BH, Bae SE, Choi KD, Choe J, Kim SO, Na HK, Choi JY, Ahn JY, Jung KW, Lee J, Kim DH, Chang HS, Song HJ, Lee GH, Jung HY, Seta T, Takahashi Y, Noguchi Y, Shikata S, Sakai T, Sakai K, Yamashita Y, Nakayama T, Leja M, Park JY, Murillo R, Liepniece-karele I, Isajevs S, Kikuste I, Rudzite D, Krike P, Parshutin S, Polaka I, Kirsners A, Santare D, Folkmanis V, Daugule I, Plummer M, Herrero R, Tsukamoto T, Nakagawa M, Kiriyama Y, Toyoda T, Cao X, Corral JE, Mera R, Dye CW, Morgan DR, Lee YC, Lin JT, Garcia Martin R, Matia Cubillo A, Lee SH, Park JM, Han YM, Ko WJ, Hahm KB, Leontiadis GI, Ford AC, Ichinose M, Sugano K, Jeong M, Park JM, Han YM, Park KY, Lee DH, Yoo JH, Cho JY, Hahm KB, Bang CS, Baik GH, Shin IS, Kim JB, Suk KT, Yoon JH, Kim YS, Kim DJ
* Helicobacter pylori Eradication for Prevention of Metachronous Recurrence after Endoscopic Resection of Early Gastric Cancer (297 views)
N Engl J Med (ISSN: 0028-4793, 0028-4793linking, 1533-4406electronic), 2015 Jun; 30642104201566393291: 749-756.
Impact Factor: 59.558
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Vicidomini C, Panico M, Greco A, Gargiulo S, Coda ARD, Zannetti A, Gramanzini M, Roviello GN, Quarantelli M, Alfano B, Tavitian B, Dolle F, Salvatore M, Brunetti A, Pappata S
* In vivo imaging and characterization of [(18)F]DPA-714, a potential new TSPO ligand, in mouse brain and peripheral tissues using small-animal PET (732 views) (PDF 263 views)
Nucl Med Biol (ISSN: 0969-8051, 0883-2897), 2015 Mar; 42(3): 309-316.
Impact Factor: 2.429
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Klauzinska M, Bertolette D, Tippireddy S, Strizzi L, Gray PC, Gonzales M, Duroux M, Ruvo M, Wechselberger C, Castro NP, Rangel MC, Focà A, Sandomenico A, Hendrix MJC, Salomon D, Cuttitta F
* Cripto-1: an extracellular protein – connecting the sequestered biological dots (296 views)
Connect Tissue Res (ISSN: 0300-8207), 2015; N/D: N/D-N/D.
Impact Factor: 1.411
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Quarantelli M
* MRI/MRS in neuroinflammation: methodology and applications (296 views)
Clin Transl Imaging (ISSN: 2281-5872print, 2281-5872linking), 2015; 3: 475-489.
Impact Factor: 0
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Di Lorenzo F, Silipo A, Bianconi I, Lore' NI, Scamporrino A, Sturiale L, Garozzo D, Lanzetta R, Parrilli M, Bragonzi A, Molinaro A
* Persistent cystic fibrosis isolate Pseudomonas aeruginosa strain RP73 exhibits an under-acylated LPS structure responsible of its low inflammatory activity (363 views)
Mol Immunol (ISSN: 0161-5890), 2015; 63(2): 166-175.
Impact Factor: 3.375
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Gargiulo S, Petretta MP, Greco A, Panico M, Larobina M, Gramanzini M, Schiattarella GG, Esposito G, Petretta M, Brunetti A, Cuocolo A
* Genetic deletion in uncoupling protein 3 augments 18F-fluorodeoxyglucose cardiac uptake in the ischemic heart (434 views)
Bmc Cardiovasc Disor (ISSN: 1471-2261), 2014 Sep 8; 14(1): 98-98.
Impact Factor: 1.878
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Musumeci D, Roviello GN, Montesarchio D
* An overview on HMGB1 inhibitors as potential therapeutic agents in HMGB1-related pathologies (555 views)
Pharmacol Ther (ISSN: 0163-7258, 0163-7258linking), 2014 Mar; 141(3): 347-357.
Impact Factor: 9.723
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Vitale M, Luongo D, Naviglio D, Bozzetto L, Mirabella M, Rivieccio AM, Giacco A, Rivellese AA
* Trans fatty acids consumption in type 1 diabetic patients: evaluation by dietary records and measurement in serum phospholipids (388 views)
Acta Diabetol (ISSN: 0940-5429, 1432-5233electronic), 2013 Aug; 50(4): 651-654.
Impact Factor: 3.679
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Madonna S, Scarponi C, Doti N, Carbone T, Cavani A, Scognamiglio PL, Marasco D, Albanesi C
* Therapeutical potential of a peptide mimicking the SOCS1 kinase inhibitory region in skin immune responses (584 views)
Eur J Immunol (ISSN: 0014-2980), 2013 Jul; 43(7): 1883-1895.
Impact Factor: 4.518
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Lombardo B, Rocco T, Esposito MT, Cantilena B, Gargiulo S, Greco A, Montanaro D, Brunetti A, Pastore L
* Thymidine Kinase-Mediated Shut Down of Bone Morphogenetic Protein-4 Expression Allows Regulated Bone Production (350 views)
Current Gene Therapy (ISSN: 1566-5232, 1875-5631), 2013 Jun 1; 13(3): 202-210.
Impact Factor: 4.906
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Castiglione F, Mainenti PP, De Palma GD, Testa A, Bucci L, Pesce G, Camera L, Diaferia M, Rea M, Caporaso N, Salvatore M, Rispo A
* Noninvasive diagnosis of small bowel crohn's disease: Direct comparison of bowel sonography and magnetic resonance enterography (471 views)
Inflamm Bowel Dis (ISSN: 1078-0998, 1536-4844electronic, 1078-0998linking), 2013 Apr; 19(4): 991-998.
Impact Factor: 5.475
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Greco A, Fiumara G, Gargiulo S, Gramanzini M, Brunetti A, Cuocolo A
* High-resolution positron emission tomography/computed tomography imaging of the mouse heart (466 views)
Exp Physiol Experimental Physiology (ISSN: 1469-445x, 0958-0670), 2013 Mar; 98(3): 645-651.
Impact Factor: 2.871
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Ciccarelli M, Sorriento D, Franco A, Fusco A, Del Giudice C, Annunziata R, Cipolletta E, Monti MG, Dorn GW, Trimarco B, Iaccarino G
* Endothelial G protein-coupled receptor kinase 2 regulates vascular homeostasis through the control of free radical oxygen species (461 views)
Arterioscler Thromb Vasc Biol Arteriosclerosis Thrombosis And Vascular Biology (ISSN: 1079-5642, 1049-8834), 2013; 33(10): 2415-2424.
Impact Factor: 5.533
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Sorriento D, Fusco A, Ciccarelli M, Rungi A, Anastasio A, Carillo A, Dorn II GW, Trimarco B, Iaccarino G
* Mitochondrial G protein coupled receptor kinase 2 regulates proinflammatory responses in macrophages (385 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 2013; 587(21): 3487-3494.
Impact Factor: 3.341
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Dolga AM, Letsche T, Gold M, Doti N, Bacher M, Chiamvimonvat N, Dodel R, Culmsee C
* Activation of KCNN3/SK3/K(Ca)2. 3 channels attenuates enhanced calcium influx and inflammatory cytokine production in activated microglia (552 views)
Glia (ISSN: 1098-1136), 2012 Dec; 60(12): 2050-2064.
Impact Factor: 5.466
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Berisio R
* Learning from pathogens: Exploiting host-pathogen liaison for therapeutic development (508 views)
Curr Protein Pept Sci (ISSN: 1389-2037, 1389-2037linking), 2012 Dec; 13(8): 697-698.
Impact Factor: 2.326
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Fusari M, Sorrentino N, Bottazzi EC, Del Vecchio W, Cozzolino I, Maurea S, Salvatore M, Imbriaco M
* Primary signet ring cell carcinoma of the appendix mimicking acute appendicitis (208 views)
Acta Radiologica Short Reports (ISSN: 2047-9816), 2012 Oct 5; 1(9): 2012-2012.
Impact Factor: 1.35
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Jacobs AH, Tavitian B, TheInmindG, Pappata S, Quarantelli M
* Noninvasive molecular imaging of neuroinflammation (335 views) (PDF 196 views)
J Cereb Blood Flow Metab (ISSN: 0271-678x, 1559-7016electronic), 2012 Jul; 32(7): 1393-1415.
Impact Factor: 5.398
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Pier PM
* RE: Imaging Features of Hepato-Splenic Amyloidosis at PET/CT (293 views)
Korean Journal Of Radiology (ISSN: 1229-6929), 2012 May; 13(3): 368-369.
Impact Factor: 1.555
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Vitiello M, Galdiero M, Finamore E, Galdiero S, Galdiero M
* NF-κB as a potential therapeutic target in microbial diseases (484 views)
Mol Biosyst (ISSN: 1742-206x), 2012; 8(4): 1108-1120.
Impact Factor: 3.35
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Gargiulo S, Greco A, Gramanzini M, Petretta MP, Ferro A, Larobina M, Panico M, Brunetti A, Cuocolo A
* PET/CT imaging in mouse models of myocardial ischemia (666 views)
J Biomed Biotechnol (ISSN: 1110-7251, 1110-7243), 2012; 2012: 541872-541872.
Impact Factor: 2.88
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Di Paola R, Impellizzeri D, Salinaro AT, Mazzon E, Bellia F, Cavallaro M, Cornelius C, Vecchio G, Calabrese V, Rizzarelli E, Cuzzocrea S
* Administration of carnosine in the treatment of acute spinal cord injury (604 views)
Biochem Pharmacol Biochemical Pharmacology (ISSN: 1873-2968, 0006-2952), 2011 Nov 15; 82(10): 1478-1489.
Impact Factor: 4.705
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Cuocolo A
Current research in nuclear medicine and molecular imaging in Italy: Highlights of the 10th National Congress of the Italian Association of Nuclear Medicine and Molecular Imaging (463 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2011 Jun; 55(3): 280-300.
Impact Factor: 1.724
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Acampa W, Di Taranto MD, Morgante A, Salvatore B, Evangelista L, Ricci F, Costanzo P, De Sisto E, Filardi PP, Petretta M, Fortunato G, Cuocolo A
* C-reactive protein levels are associated with paraoxonase polymorphism L55M in patients undergoing cardiac SPECT imaging (377 views)
Scand J Clin Lab Invest (ISSN: 0036-5513, 1502-7686), 2011 May; 71(3): 179-184.
Impact Factor: 1.156
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Rossi FF, Pedone C, Antonelli Incalzi R
Chronic obstructive pulmonary disease and cardiovascular disease: role of the systemic inflammation (445 views)
Recenti Prog Med (ISSN: 0034-1193, 0034-1193print), 2011 Mar; 102(3): 109-113.
Impact Factor: 0.318
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Severino V, Chambery A, Vitiello M, Cantisani M, Galdiero S, Galdiero M, Malorni L, Di Maro A, Parente A
* Proteomic Analysis of Human U937 Cell Line Activation Mediated by Haemophilus influenzae Type b P2 Porin and Its Surface-Exposed Loop (460 views)
J Proteome Res (ISSN: 1535-3893), 2010 Feb; 9(2): 1050-1062.
Impact Factor: 5.46
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Cigliano L, Pugliese CR, Spagnuolo MS, Palumbo R, Abrescia P
* Haptoglobin binds the antiatherogenic protein apolipoprotein e - Impairment of apolipoprotein e stimulation of both lecithin: Cholesterol acyltransferase activity and cholesterol uptake by hepatocytes (396 views)
Febs J (ISSN: 1742-464x), 2009 Nov; 276(21): 6158-6171.
Impact Factor: 3.042
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Vergote J, Chalon S, Emond P, Vercouillie J, Pappata S, Guilloteau D
* New SPECT and PET dementia tracers (358 views)
Med Nucl (ISSN: 0928-1258), 2009 Mar; 33(3): 137-141.
Impact Factor: 0.155
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Sorriento D, Campanile A, Santulli G, Leggiero E, Pastore L, Trimarco B, Iaccarino G
* A new synthetic protein, TAT-RH, inhibits tumor growth through the regulation of NFκB activity (358 views)
Mol Cancermolecular Cancer (ISSN: 1476-4598), 2009; 8: N/D-N/D.
Impact Factor: 4.16
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Chiechio S, Zammataro M, Morales ME, Busceti CL, Drago F, Th Gereau RW, Copani A, Nicoletti F
* Epigenetic modulation of mGlu2 receptors by histone deacetylase inhibitors in the treatment of inflammatory pain (497 views)
Mol Pharmacol (ISSN: 0026-895x), 2009; 75(5): 1014-1020.
Impact Factor: 4.531
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Sorriento D, Ciccarelli M, Santulli G, Campanile A, Altobelli GG, Cimini V, Galasso G, Astone D, Piscione F, Pastore L, Trimarco B, Iaccarino G
* The G-protein-coupled receptor kinase 5 inhibits NFκB transcriptional activity by inducing nuclear accumulation of IκBα (438 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2008; 105(46): 17818-17823.
Impact Factor: 9.38
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Martinelli P, Maruotti GM, Oppedisano R, Agangi A, Mazzarelli LL, Votino C, Quarantelli M, Iaccarino V
* Is uterine artery embolization for cervical ectopic pregnancy always safe? (320 views)
J Minimally Invasive Gynecol (ISSN: 1553-4650), 2007 Nov; 14(6): 758-763.
Impact Factor: 1.607
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Salvatore A, Cigliano L, Bucci EM, Corpillo D, Velasco S, Carlucci A, Pedone C, Abrescia P
* Haptoglobin binding to apolipoprotein A-I prevents damage from hydroxyl radicals on its stimulatory activity of the enzyme lecithin-cholesterol acyl-transferase (407 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2007 Oct 2; 46(39): 11158-11168.
Impact Factor: 3.368
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Cuzzocrea S, Genovese T, Failla M, Vecchio G, Fruciano M, Mazzon E, Di Paola R, Muià C, La Rosa C, Crimi N, Rizzarelli E, Vancheri C
* Protective effect of orally administered carnosine on bleomycin-induced lung injury (575 views)
Am J Physiol Lung Cell Mol Physiol (ISSN: 1040-0605), 2007 May; 292(5): L1095-L1095.
Impact Factor: 4.214
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Musumeci D, Roviello GN, Moccia M, Pedone C, Bucci EM, Sapio R, Valente M, Fumero S
* Bent oligonucleotide duplexes as HMGB1 inhibitors: A comparative study (348 views)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1525-7770), 2007; 26(10-12): 1447-1450.
Impact Factor: 0.723
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Bucci EM, Valente M, Musumeci D, Sapio R, Anrò V, Roviello GN, Moccia M
* ODN-based drugs for targeting of extracellular proteins (284 views)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1525-7770), 2007; 26(8-9): 1047-1050.
Impact Factor: 0.723
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Galdiero S, Vitiello M, Amodeo P, D'Isanto M, Cantisani M, Pedone C, Galdiero M
* Structural requirements for proinflammatory activity of porin P2 loop 7 from Haemophilus influenzae (514 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2006 Apr 11; 45(14): 4491-4501.
Impact Factor: 3.633
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Cuocolo A, Acampa W, Varrone A, Salvatore M
* Highlights of the Annual Congress of the European Association of Nuclear Medicine, Istanbul, 2005: The incremental value of nuclear medicine for patient management and care (584 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2006 Mar; 33(3): 360-381.
Impact Factor: 4.041
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Marino M, Rossi M, Ruvo M, Fassina G
* Novel molecular targets for systemic lupus erythematosus (369 views)
Curr Drug Targets (ISSN: 1389-4501), 2002 Jun; 3(3): 223-228.
Impact Factor: 3.597
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Lombardi A, De Simone G, Galdiero S, Staiano N, Nastri F, Pavone V
From natural to synthetic multisite thrombin inhibitors (349 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1999; 51(1): 19-39.
Impact Factor: 2.331
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Lombardi A, D'Agostino B, Filippelli A, Pedone C, Matera MG, Falciani M, De Rosa M, Rossi F, Pavone V
Neuronorm is a potent and water soluble neurokinin A receptor antagonist (387 views)
Bioorganic & Medicinal Chemistry Letters (ISSN: 0960-894x), 1998 Jul 7; 8(13): 1735-1740.
Impact Factor: 1.5
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Testino G, Leone S, Fagoonee S, Del Bas JM, Rodriguez B, Puiggros F, Marine S, Rodriguez MA, Morina D, Armengol L, Caimari A, Arola L, Cimini FA, Barchetta I, Carotti S, Bertoccini L, Baroni MG, Vespasiani-gentilucci U, Cavallo MG, Morini S, Nelson JE, Roth CL, Wilson LA, Yates KP, Aouizerat B, Morgan-stevenson V, Whalen E, Hoofnagle A, Mason M, Gersuk V, Yeh MM, Kowdley KV, Lee SM, Jun DW, Cho YK, Jang KS, Kucukazman M, Ata N, Dal K, Yeniova AO, Kefeli A, Basyigit S, Aktas B, Akin KO, Agladioglu K, Ure OS, Topal F, Nazligul Y, Beyan E, Ertugrul DT, Catena C, Cosma C, Camozzi V, Plebani M, Ermani M, Sechi LA, Fallo F, Goto Y, Ray MB, Mendenhall CL, French SW, Gartside PS
Serum vitamin A deficiency and increased intrahepatic expression of cytokeratin antigen in alcoholic liver disease (600 views)
Hepatology (ISSN: 1827-1669electronic, 0026-4806linking), 1988 Sep; 83120693611123109(5): 1019-1026.
Impact Factor: 0.913
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67 Records (63 excluding Abstracts).
Total impact factor: 308.903 (298.581 excluding Abstracts).
Total 5 year impact factor: 244.038 (233.688 excluding Abstracts).
Total impact factor: 308.903 (298.581 excluding Abstracts).
Total 5 year impact factor: 244.038 (233.688 excluding Abstracts).
323 views. Last view on Saturday 14 January 2023, 15:40:12
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