Predictors of In-Hospital and Long-Term Clinical Outcome in Elderly Patients with Massive Pulmonary Embolism Receiving Thrombolytic Therapy (369 views)
J Am Geriatr Soc (ISSN: 0002-8614), 2008 Dec; 56(12): 2273-2277.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 3.805, 5-year impact factor: 4.914
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-57149124238&partnerID=40&md5=4dcd81737ea4af5b58ad88f567dd2ffd
Keywords: Outcome Predictors, Pulmonary Embolism, Thrombolysis, Alteplase, Anticoagulant Agent, Heparin, Troponin I, Article, Blood Clot Lysis, Cardiogenic Shock, Computed Tomographic Angiography, Continuous Infusion, Controlled Study, Female, Follow Up, Heart Arrhythmia, Hospital Admission, Hospital Discharge, Hospitalization, Human, Hypovolemia, Lung Embolism, Major Clinical Study, Outcome Assessment, Prognosis, Risk Factor, Sepsis, Systolic Blood Pressure, Thrombocytopenia, Case-Control Studies, Retrospective Studies, Thrombolytic Therapy, Time Factors, Treatment Outcome,
Affiliations:
*** IBB - CNR ***
Geriatric Unit, Rossano Calabro Hospital, Rossano Calabro, Italy
Department of Clinical and Experimental Medicine, Federico II University, Naples, Italy
Department of Emergency Medicine, Antonio Cardarelli Hospital, Naples, Italy
References:
Righini, M., Le Gal, G., Perrier, A., The challenge of diagnosing pulmonary embolism in elderly patients: Influence of age on commonly used diagnostic tests and strategies (2005) J Am Geriatr Soc, 53, pp. 1039-104
Punukollu, H., Khan, I.A., Punukollu, G., Acute pulmonary embolism in elderly: Clinical characteristics and outcome (2005) Int J Cardiol, 99, pp. 213-216
Berman, A.R., Arnsten, J.H., Diagnosis and treatment of pulmonary embolism in the elderly (2003) Clin Geriatr Med, 19, pp. 157-175
Goldhaber, S.Z., Elliott, C.G., Acute pulmonary embolism: Part I: Epidemiology, pathophysiology, and diagnosis (2003) Circulation, 108, pp. 2726-2729
Berman, A.R., Pulmonary embolism in the elderly (2001) Clin Geriatr Med, 17, pp. 107-130
Guidelines on diagnosis and management of acute pulmonary embolism. Task force on pulmonary embolism, European Society of Cardiology (2000) Eur Heart J, 21, pp. 1301-1336
Gallotta, G., Palmieri, V., Piedimonte, V., Increased troponin I predicts in-hospital occurrence of hemodynamic instability in patients with sub-massive or non-massive pulmonary embolism independent to clinical, echocardiographic and laboratory information (2008) Int J Cardiol, 124, pp. 351-357
Harrigan, R.A., Jones, K., ABC of clinical electrocardiography. Conditions affecting the right side of the heart (2002) BMJ, 324, pp. 1201-1204
Kasper, W., Konstantinides, S., Geibel, A., Management strategies and determinants of outcome in acute major pulmonary embolism: Results of a multicenter registry (1997) J Am Coll Cardiol, 30, pp. 1165-1171
Warkentin, T.E., Heparin-induced thrombocytopenia: Pathogenesis and management (2003) Br J Haematol, 121, pp. 535-555
Rodger, M., Wells, P., Diagnosis of pulmonary embolism (2001) Thromb Res, 103, pp. V225-V238
Schoepf, U.J., Costello, P., CT angiography for diagnosis of pulmonary embolism: State of the art (2004) Radiology, 230, pp. 329-337
Lopez-Jimenez, L., Montero, M., Gonzalez-Fajardo, J.A., RIETE investigators. Venous thromboembolism in very elderly patients: Findings from a prospective registry (RIETE) (2006) Haematologica, 91, pp. 1046-1051
Beemath, A., Stein, P.D., Skaf, E., Risk of venous thromboembolism in patients hospitalized with heart failure (2006) Am J Cardiol, 98, pp. 793-795
Lyman, S., Sherman, S., Carter, T.I., Prevalence and risk factors for symptomatic thromboembolic events after shoulder arthroplasty (2006) Clin Orthop Relat Res, 448, pp. 152-156
Ray, P., Birolleau, S., Lefort, Y., Acute respiratory failure in the elderly: Etiology, emergency diagnosis and prognosis (2006) Crit Care, 10, pp. R82
Smeeth, L., Cook, C., Thomas, S., Risk of deep vein thrombosis and pulmonary embolism after acute infection in a community setting (2006) Lancet, 367, pp. 1075-1079
Tillie-Leblond, I., Marquette, C.H., Perez, T., Pulmonary embolism in patients with unexplained exacerbation of chronic obstructive pulmonary disease: Prevalence and risk factors (2006) Ann Intern Med, 144, pp. 390-396
Kwong, L.M., Hip fracture and venous thromboembolism in the elderly (2004) J Surg Orthop Adv, 13, pp. 139-148
Van Gerpen, R., Mast, M.E., Thromboembolic disorders in cancer (2004) Clin J Oncol Nurs, 8, pp. 289-299
Meneveau, N., Ming, L.P., Seronde, M.F., In-hospital and long-term outcome after sub-massive and massive pulmonary embolism submitted to thrombolytic therapy (2003) Eur Heart J, 24, pp. 1447-1454
Sukhija, R., Aronow, W.S., Lee, J., Association of right ventricular dysfunction with in-hospital mortality in patients with acute pulmonary embolism and reduction in mortality in patients with right ventricular dysfunction by pulmonary embolectomy (2005) Am J Cardiol, 95, pp. 695-696
Kucher, N., Goldhaber, S.Z., Cardiac biomarkers for risk stratification of patients with acute pulmonary embolism (2003) Circulation, 108, pp. 2191-2194
Kucher, N., Wallmann, D., Carone, A., Incremental prognostic value of troponin I and echocardiography in patients with acute pulmonary embolism (2003) Eur Heart J, 24, pp. 1651-1656
Giannitsis, E., Muller-Bardorff, M., Kurowski, V., Independent prognostic value of cardiac troponin T in patients with confirmed pulmonary embolism (2000) Circulation, 102, pp. 211-217
Carson, J.L., Kelley, M.A., Duff, A., The clinical course of pulmonary embolism (1992) N Engl J Med, 326, pp. 1240-1245
Goldhaber, S.Z., Visani, L., De Rosa, M., Acute pulmonary embolism: Clinical outcomes in the International Cooperative Pulmonary Embolism Registry (1999) Lancet, 353, pp. 1386-1389
Goldhaber, S.Z., Pulmonary embolism (2004) Lancet, 363, pp. 1295-1305
Berman, A. R., Arnsten, J. H., Diagnosis and treatment of pulmonary embolism in the elderly (2003) Clin Geriatr Med, 19, pp. 157-175
Goldhaber, S. Z., Elliott, C. G., Acute pulmonary embolism: Part I: Epidemiology, pathophysiology, and diagnosis (2003) Circulation, 108, pp. 2726-2729
Berman, A. R., Pulmonary embolism in the elderly (2001) Clin Geriatr Med, 17, pp. 107-130
Harrigan, R. A., Jones, K., ABC of clinical electrocardiography. Conditions affecting the right side of the heart (2002) BMJ, 324, pp. 1201-1204
Warkentin, T. E., Heparin-induced thrombocytopenia: Pathogenesis and management (2003) Br J Haematol, 121, pp. 535-555
Schoepf, U. J., Costello, P., CT angiography for diagnosis of pulmonary embolism: State of the art (2004) Radiology, 230, pp. 329-337
Kwong, L. M., Hip fracture and venous thromboembolism in the elderly (2004) J Surg Orthop Adv, 13, pp. 139-148
Carson, J. L., Kelley, M. A., Duff, A., The clinical course of pulmonary embolism (1992) N Engl J Med, 326, pp. 1240-1245
Goldhaber, S. Z., Visani, L., De Rosa, M., Acute pulmonary embolism: Clinical outcomes in the International Cooperative Pulmonary Embolism Registry (1999) Lancet, 353, pp. 1386-1389
Goldhaber, S. Z., Pulmonary embolism (2004) Lancet, 363, pp. 1295-1305
J Am Geriatr Soc (ISSN: 0002-8614), 2008 Dec; 56(12): 2273-2277.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 3.805, 5-year impact factor: 4.914
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-57149124238&partnerID=40&md5=4dcd81737ea4af5b58ad88f567dd2ffd
Keywords: Outcome Predictors, Pulmonary Embolism, Thrombolysis, Alteplase, Anticoagulant Agent, Heparin, Troponin I, Article, Blood Clot Lysis, Cardiogenic Shock, Computed Tomographic Angiography, Continuous Infusion, Controlled Study, Female, Follow Up, Heart Arrhythmia, Hospital Admission, Hospital Discharge, Hospitalization, Human, Hypovolemia, Lung Embolism, Major Clinical Study, Outcome Assessment, Prognosis, Risk Factor, Sepsis, Systolic Blood Pressure, Thrombocytopenia, Case-Control Studies, Retrospective Studies, Thrombolytic Therapy, Time Factors, Treatment Outcome,
Affiliations:
*** IBB - CNR ***
Geriatric Unit, Rossano Calabro Hospital, Rossano Calabro, Italy
Department of Clinical and Experimental Medicine, Federico II University, Naples, Italy
Department of Emergency Medicine, Antonio Cardarelli Hospital, Naples, Italy
References:
Righini, M., Le Gal, G., Perrier, A., The challenge of diagnosing pulmonary embolism in elderly patients: Influence of age on commonly used diagnostic tests and strategies (2005) J Am Geriatr Soc, 53, pp. 1039-104
Punukollu, H., Khan, I.A., Punukollu, G., Acute pulmonary embolism in elderly: Clinical characteristics and outcome (2005) Int J Cardiol, 99, pp. 213-216
Berman, A.R., Arnsten, J.H., Diagnosis and treatment of pulmonary embolism in the elderly (2003) Clin Geriatr Med, 19, pp. 157-175
Goldhaber, S.Z., Elliott, C.G., Acute pulmonary embolism: Part I: Epidemiology, pathophysiology, and diagnosis (2003) Circulation, 108, pp. 2726-2729
Berman, A.R., Pulmonary embolism in the elderly (2001) Clin Geriatr Med, 17, pp. 107-130
Guidelines on diagnosis and management of acute pulmonary embolism. Task force on pulmonary embolism, European Society of Cardiology (2000) Eur Heart J, 21, pp. 1301-1336
Gallotta, G., Palmieri, V., Piedimonte, V., Increased troponin I predicts in-hospital occurrence of hemodynamic instability in patients with sub-massive or non-massive pulmonary embolism independent to clinical, echocardiographic and laboratory information (2008) Int J Cardiol, 124, pp. 351-357
Harrigan, R.A., Jones, K., ABC of clinical electrocardiography. Conditions affecting the right side of the heart (2002) BMJ, 324, pp. 1201-1204
Kasper, W., Konstantinides, S., Geibel, A., Management strategies and determinants of outcome in acute major pulmonary embolism: Results of a multicenter registry (1997) J Am Coll Cardiol, 30, pp. 1165-1171
Warkentin, T.E., Heparin-induced thrombocytopenia: Pathogenesis and management (2003) Br J Haematol, 121, pp. 535-555
Rodger, M., Wells, P., Diagnosis of pulmonary embolism (2001) Thromb Res, 103, pp. V225-V238
Schoepf, U.J., Costello, P., CT angiography for diagnosis of pulmonary embolism: State of the art (2004) Radiology, 230, pp. 329-337
Lopez-Jimenez, L., Montero, M., Gonzalez-Fajardo, J.A., RIETE investigators. Venous thromboembolism in very elderly patients: Findings from a prospective registry (RIETE) (2006) Haematologica, 91, pp. 1046-1051
Beemath, A., Stein, P.D., Skaf, E., Risk of venous thromboembolism in patients hospitalized with heart failure (2006) Am J Cardiol, 98, pp. 793-795
Lyman, S., Sherman, S., Carter, T.I., Prevalence and risk factors for symptomatic thromboembolic events after shoulder arthroplasty (2006) Clin Orthop Relat Res, 448, pp. 152-156
Ray, P., Birolleau, S., Lefort, Y., Acute respiratory failure in the elderly: Etiology, emergency diagnosis and prognosis (2006) Crit Care, 10, pp. R82
Smeeth, L., Cook, C., Thomas, S., Risk of deep vein thrombosis and pulmonary embolism after acute infection in a community setting (2006) Lancet, 367, pp. 1075-1079
Tillie-Leblond, I., Marquette, C.H., Perez, T., Pulmonary embolism in patients with unexplained exacerbation of chronic obstructive pulmonary disease: Prevalence and risk factors (2006) Ann Intern Med, 144, pp. 390-396
Kwong, L.M., Hip fracture and venous thromboembolism in the elderly (2004) J Surg Orthop Adv, 13, pp. 139-148
Van Gerpen, R., Mast, M.E., Thromboembolic disorders in cancer (2004) Clin J Oncol Nurs, 8, pp. 289-299
Meneveau, N., Ming, L.P., Seronde, M.F., In-hospital and long-term outcome after sub-massive and massive pulmonary embolism submitted to thrombolytic therapy (2003) Eur Heart J, 24, pp. 1447-1454
Sukhija, R., Aronow, W.S., Lee, J., Association of right ventricular dysfunction with in-hospital mortality in patients with acute pulmonary embolism and reduction in mortality in patients with right ventricular dysfunction by pulmonary embolectomy (2005) Am J Cardiol, 95, pp. 695-696
Kucher, N., Goldhaber, S.Z., Cardiac biomarkers for risk stratification of patients with acute pulmonary embolism (2003) Circulation, 108, pp. 2191-2194
Kucher, N., Wallmann, D., Carone, A., Incremental prognostic value of troponin I and echocardiography in patients with acute pulmonary embolism (2003) Eur Heart J, 24, pp. 1651-1656
Giannitsis, E., Muller-Bardorff, M., Kurowski, V., Independent prognostic value of cardiac troponin T in patients with confirmed pulmonary embolism (2000) Circulation, 102, pp. 211-217
Carson, J.L., Kelley, M.A., Duff, A., The clinical course of pulmonary embolism (1992) N Engl J Med, 326, pp. 1240-1245
Goldhaber, S.Z., Visani, L., De Rosa, M., Acute pulmonary embolism: Clinical outcomes in the International Cooperative Pulmonary Embolism Registry (1999) Lancet, 353, pp. 1386-1389
Goldhaber, S.Z., Pulmonary embolism (2004) Lancet, 363, pp. 1295-1305
Berman, A. R., Arnsten, J. H., Diagnosis and treatment of pulmonary embolism in the elderly (2003) Clin Geriatr Med, 19, pp. 157-175
Goldhaber, S. Z., Elliott, C. G., Acute pulmonary embolism: Part I: Epidemiology, pathophysiology, and diagnosis (2003) Circulation, 108, pp. 2726-2729
Berman, A. R., Pulmonary embolism in the elderly (2001) Clin Geriatr Med, 17, pp. 107-130
Harrigan, R. A., Jones, K., ABC of clinical electrocardiography. Conditions affecting the right side of the heart (2002) BMJ, 324, pp. 1201-1204
Warkentin, T. E., Heparin-induced thrombocytopenia: Pathogenesis and management (2003) Br J Haematol, 121, pp. 535-555
Schoepf, U. J., Costello, P., CT angiography for diagnosis of pulmonary embolism: State of the art (2004) Radiology, 230, pp. 329-337
Kwong, L. M., Hip fracture and venous thromboembolism in the elderly (2004) J Surg Orthop Adv, 13, pp. 139-148
Carson, J. L., Kelley, M. A., Duff, A., The clinical course of pulmonary embolism (1992) N Engl J Med, 326, pp. 1240-1245
Goldhaber, S. Z., Visani, L., De Rosa, M., Acute pulmonary embolism: Clinical outcomes in the International Cooperative Pulmonary Embolism Registry (1999) Lancet, 353, pp. 1386-1389
Goldhaber, S. Z., Pulmonary embolism (2004) Lancet, 363, pp. 1295-1305
Predictors of In-Hospital and Long-Term Clinical Outcome in Elderly Patients with Massive Pulmonary Embolism Receiving Thrombolytic Therapy
To determine the clinical, historical, and instrumental findings associated with unfavorable short-term and long-term prognosis in elderly patients (>= 65) receiving thrombolytic therapy for pulmonary embolism (PE). Case-control retrospective study. General medicine acute care ward. Sixty-seven elderly patients with PE complicated by hemodynamic instability (massive PE) admitted to the "Antonio Cardarelli" Hospital from January 1, 2002, to December 31, 2004, and evaluated during their hospital stay and 174.4 +/- 4.6 days after discharge. PE diagnosis was confirmed using spiral computed tomography angiography. Hemodynamic instability was defined as cardiogenic shock and systolic blood pressure less than 90 mmHg or a pressure drop of 40 mmHg or more for longer than 15 minutes not due to new-onset arrhythmia, hypovolemia, or sepsis. Weight-adapted unfractionated heparin and recombinant tissue plasminogen activator. Nine patients (13.4%) died during hospitalization. Higher troponin-I (cTn-I) serum levels at admission to the emergency department and the occurrence of thrombocytopenia after thrombolysis were significantly associated with in-hospital death. Nineteen of the 58 survivors (32.7%) died during follow-up. The risk factors for long-term death were historical findings of cancer and cardiovascular disease at hospital admission. Higher cTn-I serum levels in the acute phase and the occurrence of thrombocytopenia after thrombolysis were significantly associated with in-hospital mortality in elderly patients with massive PE. In the same setting, historical findings of cancer and cardiovascular disease are strong predictors of death in the long term.
To determine the clinical, historical, and instrumental findings associated with unfavorable short-term and long-term prognosis in elderly patients (>= 65) receiving thrombolytic therapy for pulmonary embolism (PE). Case-control retrospective study. General medicine acute care ward. Sixty-seven elderly patients with PE complicated by hemodynamic instability (massive PE) admitted to the "Antonio Cardarelli" Hospital from January 1, 2002, to December 31, 2004, and evaluated during their hospital stay and 174.4 +/- 4.6 days after discharge. PE diagnosis was confirmed using spiral computed tomography angiography. Hemodynamic instability was defined as cardiogenic shock and systolic blood pressure less than 90 mmHg or a pressure drop of 40 mmHg or more for longer than 15 minutes not due to new-onset arrhythmia, hypovolemia, or sepsis. Weight-adapted unfractionated heparin and recombinant tissue plasminogen activator. Nine patients (13.4%) died during hospitalization. Higher troponin-I (cTn-I) serum levels at admission to the emergency department and the occurrence of thrombocytopenia after thrombolysis were significantly associated with in-hospital death. Nineteen of the 58 survivors (32.7%) died during follow-up. The risk factors for long-term death were historical findings of cancer and cardiovascular disease at hospital admission. Higher cTn-I serum levels in the acute phase and the occurrence of thrombocytopenia after thrombolysis were significantly associated with in-hospital mortality in elderly patients with massive PE. In the same setting, historical findings of cancer and cardiovascular disease are strong predictors of death in the long term.
Predictors of In-Hospital and Long-Term Clinical Outcome in Elderly Patients with Massive Pulmonary Embolism Receiving Thrombolytic Therapy
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Predictors of In-Hospital and Long-Term Clinical Outcome in Elderly Patients with Massive Pulmonary Embolism Receiving Thrombolytic Therapy
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10 Records (10 excluding Abstracts).
Total impact factor: 27.749 (27.749 excluding Abstracts).
Total 5 year impact factor: 25.553 (25.553 excluding Abstracts).
Total impact factor: 27.749 (27.749 excluding Abstracts).
Total 5 year impact factor: 25.553 (25.553 excluding Abstracts).
369 views. Last view on Wednesday 15 March 2023, 14:44:48
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