Predictors of In-Hospital and Long-Term Clinical Outcome in Elderly Patients with Massive Pulmonary Embolism Receiving Thrombolytic Therapy (663 views)
J Am Geriatr Soc (ISSN: 0002-8614), 2008 Dec; 56(12): 2273-2277.
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Paper type: Journal Article,
Impact factor: 3.805, 5-year impact factor: 4.914
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-57149124238&partnerID=40&md5=4dcd81737ea4af5b58ad88f567dd2ffd
Keywords: Outcome Predictors, Pulmonary Embolism, Thrombolysis, Alteplase, Anticoagulant Agent, Heparin, Troponin I, Article, Blood Clot Lysis, Cardiogenic Shock, Computed Tomographic Angiography, Continuous Infusion, Controlled Study, Female, Follow Up, Heart Arrhythmia, Hospital Admission, Hospital Discharge, Hospitalization, Human, Hypovolemia, Lung Embolism, Major Clinical Study, Outcome Assessment, Prognosis, Risk Factor, Sepsis, Systolic Blood Pressure, Thrombocytopenia, Case-Control Studies, Retrospective Studies, Thrombolytic Therapy, Time Factors, Treatment Outcome,
Affiliations:
*** IBB - CNR ***
Geriatric Unit, Rossano Calabro Hospital, Rossano Calabro, Italy
Department of Clinical and Experimental Medicine, Federico II University, Naples, Italy
Department of Emergency Medicine, Antonio Cardarelli Hospital, Naples, Italy
References:
Not available.
J Am Geriatr Soc (ISSN: 0002-8614), 2008 Dec; 56(12): 2273-2277.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 3.805, 5-year impact factor: 4.914
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-57149124238&partnerID=40&md5=4dcd81737ea4af5b58ad88f567dd2ffd
Keywords: Outcome Predictors, Pulmonary Embolism, Thrombolysis, Alteplase, Anticoagulant Agent, Heparin, Troponin I, Article, Blood Clot Lysis, Cardiogenic Shock, Computed Tomographic Angiography, Continuous Infusion, Controlled Study, Female, Follow Up, Heart Arrhythmia, Hospital Admission, Hospital Discharge, Hospitalization, Human, Hypovolemia, Lung Embolism, Major Clinical Study, Outcome Assessment, Prognosis, Risk Factor, Sepsis, Systolic Blood Pressure, Thrombocytopenia, Case-Control Studies, Retrospective Studies, Thrombolytic Therapy, Time Factors, Treatment Outcome,
Affiliations:
*** IBB - CNR ***
Geriatric Unit, Rossano Calabro Hospital, Rossano Calabro, Italy
Department of Clinical and Experimental Medicine, Federico II University, Naples, Italy
Department of Emergency Medicine, Antonio Cardarelli Hospital, Naples, Italy
References:
Not available.
Predictors of In-Hospital and Long-Term Clinical Outcome in Elderly Patients with Massive Pulmonary Embolism Receiving Thrombolytic Therapy
To determine the clinical, historical, and instrumental findings associated with unfavorable short-term and long-term prognosis in elderly patients (>= 65) receiving thrombolytic therapy for pulmonary embolism (PE). Case-control retrospective study. General medicine acute care ward. Sixty-seven elderly patients with PE complicated by hemodynamic instability (massive PE) admitted to the "Antonio Cardarelli" Hospital from January 1, 2002, to December 31, 2004, and evaluated during their hospital stay and 174.4 +/- 4.6 days after discharge. PE diagnosis was confirmed using spiral computed tomography angiography. Hemodynamic instability was defined as cardiogenic shock and systolic blood pressure less than 90 mmHg or a pressure drop of 40 mmHg or more for longer than 15 minutes not due to new-onset arrhythmia, hypovolemia, or sepsis. Weight-adapted unfractionated heparin and recombinant tissue plasminogen activator. Nine patients (13.4%) died during hospitalization. Higher troponin-I (cTn-I) serum levels at admission to the emergency department and the occurrence of thrombocytopenia after thrombolysis were significantly associated with in-hospital death. Nineteen of the 58 survivors (32.7%) died during follow-up. The risk factors for long-term death were historical findings of cancer and cardiovascular disease at hospital admission. Higher cTn-I serum levels in the acute phase and the occurrence of thrombocytopenia after thrombolysis were significantly associated with in-hospital mortality in elderly patients with massive PE. In the same setting, historical findings of cancer and cardiovascular disease are strong predictors of death in the long term.
To determine the clinical, historical, and instrumental findings associated with unfavorable short-term and long-term prognosis in elderly patients (>= 65) receiving thrombolytic therapy for pulmonary embolism (PE). Case-control retrospective study. General medicine acute care ward. Sixty-seven elderly patients with PE complicated by hemodynamic instability (massive PE) admitted to the "Antonio Cardarelli" Hospital from January 1, 2002, to December 31, 2004, and evaluated during their hospital stay and 174.4 +/- 4.6 days after discharge. PE diagnosis was confirmed using spiral computed tomography angiography. Hemodynamic instability was defined as cardiogenic shock and systolic blood pressure less than 90 mmHg or a pressure drop of 40 mmHg or more for longer than 15 minutes not due to new-onset arrhythmia, hypovolemia, or sepsis. Weight-adapted unfractionated heparin and recombinant tissue plasminogen activator. Nine patients (13.4%) died during hospitalization. Higher troponin-I (cTn-I) serum levels at admission to the emergency department and the occurrence of thrombocytopenia after thrombolysis were significantly associated with in-hospital death. Nineteen of the 58 survivors (32.7%) died during follow-up. The risk factors for long-term death were historical findings of cancer and cardiovascular disease at hospital admission. Higher cTn-I serum levels in the acute phase and the occurrence of thrombocytopenia after thrombolysis were significantly associated with in-hospital mortality in elderly patients with massive PE. In the same setting, historical findings of cancer and cardiovascular disease are strong predictors of death in the long term.
Predictors of In-Hospital and Long-Term Clinical Outcome in Elderly Patients with Massive Pulmonary Embolism Receiving Thrombolytic Therapy
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Predictors of In-Hospital and Long-Term Clinical Outcome in Elderly Patients with Massive Pulmonary Embolism Receiving Thrombolytic Therapy
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10 Records (10 excluding Abstracts).
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Total 5 year impact factor: 25.553 (25.553 excluding Abstracts).
Total impact factor: 27.749 (27.749 excluding Abstracts).
Total 5 year impact factor: 25.553 (25.553 excluding Abstracts).
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