Sex differences in the serotonin 1A receptor and serotonin transporter binding in the human brain measured by PET (441 views visite)
Neuroimage (ISSN: 1053-8119, 1053-8119linking), 2008 Feb 1; 39(3): 1408-1419.
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Paper type Tipo di articolo: Journal Article,
Impact factor: 5.694, 5-year impact factor Impact factor a 5 anni: 6.884
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-37849032647&partnerID=40&md5=7463ebc39caf5e3369767ce135f902cb
Keywords Parole chiave: Carbon 11, N [2 [4 (2 Methoxyphenyl) 1 Piperazinyl]ethyl] N (2 Pyridyl)cyclohexanecarboxamide, Radioligand, Serotonin 1a Receptor, Serotonin Transporter, Serotonin Uptake Inhibitor, Adult, Anxiety, Article, Brain Size, Depression, Dorsal Raphe Nucleus, Female, Hippocampus, Human, Human Experiment, In Vivo Study, Neocortex, Normal Human, Nuclear Magnetic Resonance Imaging, Positron Emission Tomography, Priority Journal, Quantitative Analysis, Receptor Binding, Serotoninergic System, Sex Difference, Statistical Analysis, Suicide, Benzylamines, Biological Markers, Brain Chemistry, Cerebral Cortex, Image Processing, Computer-Assisted, Positron-Emission Tomography, Protein Binding, Pyridines, Radiopharmaceuticals, 5-Ht1a, Serotonin Antagonists, Serotonin Plasma Membrane Transport Proteins, Sex Characteristics, N [2 [4 (2 Methoxyphenyl) 1 Piperazinyl] Ethyl] N (2 Pyridyl) Cyclohexanecarboxamide,
Affiliations Affiliazioni:
*** IBB - CNR ***
Karolinska Institutet, Department of Clinical Neuroscience, Psychiatry Section, Stockholm, Sweden
References Riferimenti:
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Kessler, R.C., McGonagle, K.A., Swartz, M., Blazer, D.G., Nelson, C.B., Sex and depression in the National Comorbidity Survey. I: Lifetime prevalence, chronicity and recurrence (1993) J. Affect. Disord., 29, pp. 85-96
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Arora, R. C., Meltzer, H. Y., 3H-imipramine binding in the frontal cortex of suicides (1989) Psychiatry Res., 30, pp. 125-135
Bremner, J. D., Bronen, R. A., De Erasquin, G., Vermetten, E., Staib, L. H., Ng, C. K., Soufer, R., Innis, R. B., Development and reliability of a method for using magnetic resonance imaging for the definition of regions of interest for positron emission tomography (1998) Clin. Positron Imaging, 1, pp. 145-159
Cosgrove, K. P., Mazure, C. M., Staley, J. K., Evolving Knowledge of Sex Differences in Brain Structure, Function, and Chemistry (2007) Biol. Psychiatry, 62, pp. 847-855
David, S. P., Murthy, N. V., Rabiner, E. A., A functional genetic variation of the serotonin (5-HT) transporter affects 5-HT1A receptor binding in humans (2005) J. Neurosci., 25, pp. 2586-2590
Drevets, W. C., Frank, E., Price, J. C., Kupfer, D. J., Holt, D., Greer, P. J., Huang, Y., Mathis, C., PET imaging of serotonin 1A receptor binding in depression (1999) Biol. Psychiatry, 46, pp. 1375-1387
Epperson, C. N., Haga, K., Mason, G. F., Sellers, E., Gueorguieva, R., Zhang, W., Weiss, E., Krystal, J. H., Cortical gamma-aminobutyric acid levels across the menstrual cycle in healthy women and those with premenstrual dysphoric disorder: a proton magnetic resonance spectroscopy study (2002) Arch. Gen. Psychiatry, 59, pp. 851-858
Frankle, W. G., Huang, Y., Hwang, D. R., Talbot, P. S., Slifstein, M., Van Heertum, R., Abi-Dargham, A., Laruelle, M., Comparative evaluation of serotonin transporter radioligands 11C-DASB and 11C-McN 5652 in healthy humans (2004) J. Nucl. Med., 45, pp. 682-694
Friston, K. J., Holms, A. P., Worsley, K. J., Poline, J. B., Frith, C., Frackowiak, R. S. J., Statistical parametric maps in functional imaging: a general linear approach (1995) Hum. Brain Mapp., 2, pp. 189-210
Gorman, J. M., Gender differences in depression and response to psychotropic medication (2006) Gend. Med., 3, pp. 93-109
Gottfries, C. G., Roos, B. E., Winblad, B., Determination of 5-hydroxytryptamine, 5-hydroxyindoleacetic acid and homovanillic acid in brain tissue from an autopsy material (1974) Acta Psychiatr. Scand., 50, pp. 496-507
Gunn, R. N., Lammertsma, A. A., Hume, S. P., Cunningham, V. J., Parametric imaging of ligand-receptor binding in PET using a simplified reference region model (1997) NeuroImage, 6, pp. 279-287
Gunn, R. N., Sargent, P. A., Bench, C. J., Rabiner, E. A., Osman, S., Pike, V. W., Hume, S. P., Lammertsma, A. A., Tracer kinetic modeling of the 5-HT1A receptor ligand [carbonyl-11C] WAY-100635 for PET (1998) NeuroImage, 8, pp. 426-440
Kendler, K. S., Thornton, L. M., Gardner, C. O., Stressful life events and previous episodes in the etiology of major depression in women: an evaluation of the "kindling" hypothesis (2000) Am. J. Psychiatry, 157, pp. 1243-1251
Kessler, R. C., McGonagle, K. A., Swartz, M., Blazer, D. G., Nelson, C. B., Sex and depression in the National Comorbidity Survey. I: Lifetime prevalence, chronicity and recurrence (1993) J. Affect. Disord., 29, pp. 85-96
Krasikova, R. N., Truong, P., Halldin, C., A fully automated production of [carbolyl-11C] WAY-10035 for clinical PET studies (2003) J. Label. Compd. Radiopharm., 46, p. 244
Lee, M., Bailer, U. F., Frank, G. K., Henry, S. E., Meltzer, C. C., Price, J. C., Mathis, C. A., Kaye, W. H., Relationship of a 5-HT transporter functional polymorphism to 5-HT1A receptor binding in healthy women (2005) Mol. Psychiatry, 10, pp. 715-716
Lesch, K. P., Bengel, D., Heils, A., Sabol, S. Z., Greenberg, B. D., Petri, S., Benjamin, J., Murphy, D. L., Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region (1996) Science, 274, pp. 1527-1531
Lewinsohn, P. M., Rohde, P., Seeley, J. R., Baldwin, C. L., Gender differences in suicide attempts from adolescence to young adulthood (2001) J. Am. Acad. Child Adolesc. Psych., 40, pp. 427-434
Madeira, M. D., Lieberman, A. R., Sexual dimorphism in the mammalian limbic system (1995) Prog. Neurobiol., 45, pp. 275-333
Moses, E. L., Drevets, W. C., Smith, G., Mathis, C. A., Kalro, B. N., Butters, M. A., Leondires, M. P., Berga, S. L., Effects of estradiol and progesterone administration on human serotonin 2A receptor binding: a PET study (2000) Biol. Psychiatry, 48, pp. 854-860
Parsey, R. V., Oquendo, M. A., Simpson, N. R., Ogden, R. T., Van Heertum, R., Arango, V., Mann, J. J., Effects of sex, age, and aggressive traits in man on brain serotonin 5-HT1A receptor binding potential measured by PET using [C-11] WAY-100635 (2002) Brain Res., 954, pp. 173-182
Parsey, R. V., Arango, V., Olvet, D. M., Oquendo, M. A., Van Heertum, R. L., Mann, J. J., Regional heterogeneity of 5-HT1A receptors in human cerebellum as assessed by positron emission tomography (2005) J. Cereb. Blood Flow Metab., 25, pp. 785-793
Parsey, R. V., Hastings, R. S., Oquendo, M. A., Huang, Y. Y., Simpson, N., Arcement, J., Huang, Y., Mann, J. J., Lower serotonin transporter binding potential in the human brain during major depressive episodes (2006) Am. J. Psychiatry, 163, pp. 52-58
Parsey, R. V., Olvet, D. M., Oquendo, M. A., Huang, Y. Y., Ogden, R. T., Mann, J. J., Higher 5-HT1A receptor binding potential during a major depressive episode predicts poor treatment response: preliminary data from a naturalistic study (2006) Neuropsychopharmacology, 31, pp. 1745-1749
Pigott, T. A., Gender differences in the epidemiology and treatment of anxiety disorders (1999) J. Clin. Psychiatry, 60 (SUPPL. 18), pp. 4-15
Pugliese, A. M., Passani, M. B., Corradetti, R., Effect of the selective 5-HT1A receptor antagonist WAY 100635 on the inhibition of e. p. s. ps produced by 5-HT in the CA1 region of rat hippocampal slices (1998) Br. J. Pharmacol., 124, pp. 93-100
Reiman, E. M., Armstrong, S. M., Matt, K. S., Mattox, J. H., The application of positron emission tomography to the study of the normal menstrual cycle (1996) Hum. Reprod., 11, pp. 2799-2805
Rosecrans, J. A., Differences in brain area 5-hydroxytryptamine turnover and rearing behavior in rats and mice of both sexes (1970) Eur. J. Pharmacol., 9, pp. 379-382
Rousset, O. G., Ma, Y., Evans, A. C., Correction for partial volume effects in PET: principle and validation (1998) J. Nucl. Med., 39, pp. 904-911
Sargent, P. A., Kjaer, K. H., Bench, C. J., Rabiner, E. A., Messa, C., Meyer, J., Gunn, R. N., Cowen, P. J., Brain serotonin1A receptor binding measured by positron emission tomography with [11C] WAY-100635: effects of depression and antidepressant treatment (2000) Arch. Gen. Psychiatry, 57, pp. 174-180
Staley, J. K., Krishnan-Sarin, S., Zoghbi, S., Tamagnan, G., Fujita, M., Seibyl, J. P., Maciejewski, P. K., Innis, R. B., Sex differences in [123I] beta-CIT SPECT measures of dopamine and serotonin transporter availability in healthy smokers and nonsmokers (2001) Synapse, 41, pp. 275-284
Staley, J. K., Sanacora, G., Tamagnan, G., Maciejewski, P. K., Malison, R. T., Berman, R. M., Vythilingam, M., Innis, R. B., Sex differences in diencephalon serotonin transporter availability in major depression (2006) Biol. Psychiatry, 59, pp. 40-47
Turner, M. R., Rabiner, E. A., Hammers, A., Al-Chalabi, A., Grasby, P. M., Shaw, C. E., Brooks, D. J., Leigh, P. N., [11C] -WAY100635 PET demonstrates marked 5-HT1A receptor changes in sporadic ALS (2005) Brain, 128, pp. 896-905
van Dyck, C. H., Malison, R. T., Staley, J. K., Jacobsen, L. K., Seibyl, J. P., Laruelle, M., Baldwin, R. M., Gelernter, J., Central serotonin transporter availability measured with [123I] beta-CIT SPECT in relation to serotonin transporter genotype (2004) Am. J. Psychiatry, 161, pp. 525-531
Weiss, L. A., Pan, L., Abney, M., Ober, C., The sex-specific genetic architecture of quantitative traits in humans (2006) Nat. Genet., 38, pp. 218-222
Young, S. N., Gauthier, S., Anderson, G. M., Purdy, W. C., Tryptophan, 5-hydroxyindoleacetic acid and indoleacetic acid in human cerebrospinal fluid: interrelationships and the influence of age, sex, epilepsy and anticonvulsant drugs (1980) J. Neurol., Neurosurg. Psychiatry, 43, pp. 438-445
Neuroimage (ISSN: 1053-8119, 1053-8119linking), 2008 Feb 1; 39(3): 1408-1419.
Export to Esporta in BibTeX Export to Esporta in EndNote
Paper type Tipo di articolo: Journal Article,
Impact factor: 5.694, 5-year impact factor Impact factor a 5 anni: 6.884
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-37849032647&partnerID=40&md5=7463ebc39caf5e3369767ce135f902cb
Keywords Parole chiave: Carbon 11, N [2 [4 (2 Methoxyphenyl) 1 Piperazinyl]ethyl] N (2 Pyridyl)cyclohexanecarboxamide, Radioligand, Serotonin 1a Receptor, Serotonin Transporter, Serotonin Uptake Inhibitor, Adult, Anxiety, Article, Brain Size, Depression, Dorsal Raphe Nucleus, Female, Hippocampus, Human, Human Experiment, In Vivo Study, Neocortex, Normal Human, Nuclear Magnetic Resonance Imaging, Positron Emission Tomography, Priority Journal, Quantitative Analysis, Receptor Binding, Serotoninergic System, Sex Difference, Statistical Analysis, Suicide, Benzylamines, Biological Markers, Brain Chemistry, Cerebral Cortex, Image Processing, Computer-Assisted, Positron-Emission Tomography, Protein Binding, Pyridines, Radiopharmaceuticals, 5-Ht1a, Serotonin Antagonists, Serotonin Plasma Membrane Transport Proteins, Sex Characteristics, N [2 [4 (2 Methoxyphenyl) 1 Piperazinyl] Ethyl] N (2 Pyridyl) Cyclohexanecarboxamide,
Affiliations Affiliazioni:
*** IBB - CNR ***
Karolinska Institutet, Department of Clinical Neuroscience, Psychiatry Section, Stockholm, Sweden
References Riferimenti:
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David, S. P., Murthy, N. V., Rabiner, E. A., A functional genetic variation of the serotonin (5-HT) transporter affects 5-HT1A receptor binding in humans (2005) J. Neurosci., 25, pp. 2586-2590
Drevets, W. C., Frank, E., Price, J. C., Kupfer, D. J., Holt, D., Greer, P. J., Huang, Y., Mathis, C., PET imaging of serotonin 1A receptor binding in depression (1999) Biol. Psychiatry, 46, pp. 1375-1387
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Frankle, W. G., Huang, Y., Hwang, D. R., Talbot, P. S., Slifstein, M., Van Heertum, R., Abi-Dargham, A., Laruelle, M., Comparative evaluation of serotonin transporter radioligands 11C-DASB and 11C-McN 5652 in healthy humans (2004) J. Nucl. Med., 45, pp. 682-694
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Gunn, R. N., Lammertsma, A. A., Hume, S. P., Cunningham, V. J., Parametric imaging of ligand-receptor binding in PET using a simplified reference region model (1997) NeuroImage, 6, pp. 279-287
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Kessler, R. C., McGonagle, K. A., Swartz, M., Blazer, D. G., Nelson, C. B., Sex and depression in the National Comorbidity Survey. I: Lifetime prevalence, chronicity and recurrence (1993) J. Affect. Disord., 29, pp. 85-96
Krasikova, R. N., Truong, P., Halldin, C., A fully automated production of [carbolyl-11C] WAY-10035 for clinical PET studies (2003) J. Label. Compd. Radiopharm., 46, p. 244
Lee, M., Bailer, U. F., Frank, G. K., Henry, S. E., Meltzer, C. C., Price, J. C., Mathis, C. A., Kaye, W. H., Relationship of a 5-HT transporter functional polymorphism to 5-HT1A receptor binding in healthy women (2005) Mol. Psychiatry, 10, pp. 715-716
Lesch, K. P., Bengel, D., Heils, A., Sabol, S. Z., Greenberg, B. D., Petri, S., Benjamin, J., Murphy, D. L., Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region (1996) Science, 274, pp. 1527-1531
Lewinsohn, P. M., Rohde, P., Seeley, J. R., Baldwin, C. L., Gender differences in suicide attempts from adolescence to young adulthood (2001) J. Am. Acad. Child Adolesc. Psych., 40, pp. 427-434
Madeira, M. D., Lieberman, A. R., Sexual dimorphism in the mammalian limbic system (1995) Prog. Neurobiol., 45, pp. 275-333
Moses, E. L., Drevets, W. C., Smith, G., Mathis, C. A., Kalro, B. N., Butters, M. A., Leondires, M. P., Berga, S. L., Effects of estradiol and progesterone administration on human serotonin 2A receptor binding: a PET study (2000) Biol. Psychiatry, 48, pp. 854-860
Parsey, R. V., Oquendo, M. A., Simpson, N. R., Ogden, R. T., Van Heertum, R., Arango, V., Mann, J. J., Effects of sex, age, and aggressive traits in man on brain serotonin 5-HT1A receptor binding potential measured by PET using [C-11] WAY-100635 (2002) Brain Res., 954, pp. 173-182
Parsey, R. V., Arango, V., Olvet, D. M., Oquendo, M. A., Van Heertum, R. L., Mann, J. J., Regional heterogeneity of 5-HT1A receptors in human cerebellum as assessed by positron emission tomography (2005) J. Cereb. Blood Flow Metab., 25, pp. 785-793
Parsey, R. V., Hastings, R. S., Oquendo, M. A., Huang, Y. Y., Simpson, N., Arcement, J., Huang, Y., Mann, J. J., Lower serotonin transporter binding potential in the human brain during major depressive episodes (2006) Am. J. Psychiatry, 163, pp. 52-58
Parsey, R. V., Olvet, D. M., Oquendo, M. A., Huang, Y. Y., Ogden, R. T., Mann, J. J., Higher 5-HT1A receptor binding potential during a major depressive episode predicts poor treatment response: preliminary data from a naturalistic study (2006) Neuropsychopharmacology, 31, pp. 1745-1749
Pigott, T. A., Gender differences in the epidemiology and treatment of anxiety disorders (1999) J. Clin. Psychiatry, 60 (SUPPL. 18), pp. 4-15
Pugliese, A. M., Passani, M. B., Corradetti, R., Effect of the selective 5-HT1A receptor antagonist WAY 100635 on the inhibition of e. p. s. ps produced by 5-HT in the CA1 region of rat hippocampal slices (1998) Br. J. Pharmacol., 124, pp. 93-100
Reiman, E. M., Armstrong, S. M., Matt, K. S., Mattox, J. H., The application of positron emission tomography to the study of the normal menstrual cycle (1996) Hum. Reprod., 11, pp. 2799-2805
Rosecrans, J. A., Differences in brain area 5-hydroxytryptamine turnover and rearing behavior in rats and mice of both sexes (1970) Eur. J. Pharmacol., 9, pp. 379-382
Rousset, O. G., Ma, Y., Evans, A. C., Correction for partial volume effects in PET: principle and validation (1998) J. Nucl. Med., 39, pp. 904-911
Sargent, P. A., Kjaer, K. H., Bench, C. J., Rabiner, E. A., Messa, C., Meyer, J., Gunn, R. N., Cowen, P. J., Brain serotonin1A receptor binding measured by positron emission tomography with [11C] WAY-100635: effects of depression and antidepressant treatment (2000) Arch. Gen. Psychiatry, 57, pp. 174-180
Staley, J. K., Krishnan-Sarin, S., Zoghbi, S., Tamagnan, G., Fujita, M., Seibyl, J. P., Maciejewski, P. K., Innis, R. B., Sex differences in [123I] beta-CIT SPECT measures of dopamine and serotonin transporter availability in healthy smokers and nonsmokers (2001) Synapse, 41, pp. 275-284
Staley, J. K., Sanacora, G., Tamagnan, G., Maciejewski, P. K., Malison, R. T., Berman, R. M., Vythilingam, M., Innis, R. B., Sex differences in diencephalon serotonin transporter availability in major depression (2006) Biol. Psychiatry, 59, pp. 40-47
Turner, M. R., Rabiner, E. A., Hammers, A., Al-Chalabi, A., Grasby, P. M., Shaw, C. E., Brooks, D. J., Leigh, P. N., [11C] -WAY100635 PET demonstrates marked 5-HT1A receptor changes in sporadic ALS (2005) Brain, 128, pp. 896-905
van Dyck, C. H., Malison, R. T., Staley, J. K., Jacobsen, L. K., Seibyl, J. P., Laruelle, M., Baldwin, R. M., Gelernter, J., Central serotonin transporter availability measured with [123I] beta-CIT SPECT in relation to serotonin transporter genotype (2004) Am. J. Psychiatry, 161, pp. 525-531
Weiss, L. A., Pan, L., Abney, M., Ober, C., The sex-specific genetic architecture of quantitative traits in humans (2006) Nat. Genet., 38, pp. 218-222
Young, S. N., Gauthier, S., Anderson, G. M., Purdy, W. C., Tryptophan, 5-hydroxyindoleacetic acid and indoleacetic acid in human cerebrospinal fluid: interrelationships and the influence of age, sex, epilepsy and anticonvulsant drugs (1980) J. Neurol., Neurosurg. Psychiatry, 43, pp. 438-445
Sex differences in the serotonin 1A receptor and serotonin transporter binding in the human brain measured by PET
Women and men differ in serotonin associated psychiatric conditions, such as depression, anxiety and suicide. Despite this, very few studies focus on sex differences in the serotonin system. Of the biomarkers in the serotonin system, serotonin1A (5-HT1A) receptor is implicated in depression, and anxiety and serotonin transporter (5-HTT) is a target for selective serotonin reuptake inhibitors, psychotropic drugs used in the treatment of these disorders. The objective of the present study was to study sex related differences in the 5-HT1A receptor and 5-HTT binding potentials (BPNDs) in healthy humans, in vivo. Positron emission tomography and selective radioligands [11C]WAY100635 and [11C]MADAM were used to evaluate binding potentials for 5-HT1A receptors (14 women and 14 men) and 5-HTT (8 women and 10 men). The binding potentials were estimated both on the level of anatomical regions and voxel wise, derived by the simplified reference tissue model and wavelet/Logan plot parametric image techniques respectively. Compared to men, women had significantly higher 5-HT1A receptor and lower 5-HTT binding potentials in a wide array of cortical and subcortical brain regions. In women, there was a positive correlation between 5-HT1A receptor and 5-HTT binding potentials for the region of hippocampus. Sex differences in 5-HT1A receptor and 5-HTT BPND may reflect biological distinctions in the serotonin system contributing to sex differences in the prevalence of psychiatric disorders such as depression and anxiety. The result of the present study may help in understanding sex differences in drug treatment responses to drugs affecting the serotonin system. © 2007 Elsevier Inc. All rights reserved.
Women and men differ in serotonin associated psychiatric conditions, such as depression, anxiety and suicide. Despite this, very few studies focus on sex differences in the serotonin system. Of the biomarkers in the serotonin system, serotonin1A (5-HT1A) receptor is implicated in depression, and anxiety and serotonin transporter (5-HTT) is a target for selective serotonin reuptake inhibitors, psychotropic drugs used in the treatment of these disorders. The objective of the present study was to study sex related differences in the 5-HT1A receptor and 5-HTT binding potentials (BPNDs) in healthy humans, in vivo. Positron emission tomography and selective radioligands [11C]WAY100635 and [11C]MADAM were used to evaluate binding potentials for 5-HT1A receptors (14 women and 14 men) and 5-HTT (8 women and 10 men). The binding potentials were estimated both on the level of anatomical regions and voxel wise, derived by the simplified reference tissue model and wavelet/Logan plot parametric image techniques respectively. Compared to men, women had significantly higher 5-HT1A receptor and lower 5-HTT binding potentials in a wide array of cortical and subcortical brain regions. In women, there was a positive correlation between 5-HT1A receptor and 5-HTT binding potentials for the region of hippocampus. Sex differences in 5-HT1A receptor and 5-HTT BPND may reflect biological distinctions in the serotonin system contributing to sex differences in the prevalence of psychiatric disorders such as depression and anxiety. The result of the present study may help in understanding sex differences in drug treatment responses to drugs affecting the serotonin system. © 2007 Elsevier Inc. All rights reserved.
Sex differences in the serotonin 1A receptor and serotonin transporter binding in the human brain measured by PET
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Sex differences in the serotonin 1A receptor and serotonin transporter binding in the human brain measured by PET
Quarantelli M, Palladino O, Prinster A, Schiavone V, Carotenuto B, Brunetti A, Marsili A, Casiello M, Muscettola G, Salvatore M, De Bartolomeis A
* Patients with poor response to antipsychotics have a more severe pattern of frontal atrophy: a voxel-based morphometry study of treatment resistance in schizophrenia (300 visite)
Biomed Res Int (ISSN: 2314-6133, 2314-6141, 2314-6141electronic), 2014; 2014: 325052-325052.
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Dettagli Esporta in BibTeX Esporta in EndNote
Sasaki T, Ito H, Kimura Y, Arakawa R, Takano H, Seki C, Kodaka F, Fujie S, Takahata K, Nogami T, Suzuki M, Fujiwara H, Takahashi H, Nakao R, Fukumura T, Varrone A, Halldin C, Nishikawa T, Suhara T
* Quantification of dopamine transporter in human brain using PET with 18F-FE-PE2I (379 visite)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 2012 Jul; 53(7): 1065-1073.
Impact Factor: 5.774
Dettagli Esporta in BibTeX Esporta in EndNote
Takano A, Gulyas B, Varrone A, Karlsson P, Sjoholm N, Larsson S, Jonsson C, Odh R, Sparks R, Al Tawil N, Hoffmann A, Zimmermann T, Thiele A, Halldin C
* Biodistribution and radiation dosimetry of the 18 kDa translocator protein (TSPO) radioligand [ 18F]FEDAA1106: A human whole-body PET study (398 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2011 Nov; 38(11): 2058-2065.
Impact Factor: 4.991
Dettagli Esporta in BibTeX Esporta in EndNote
Esmaeilzadeh M, Farde L, Karlsson P, Varrone A, Halldin C, Waters S, Tedroff J
* Extrastriatal dopamine D 2 receptor binding in Huntington's disease (412 visite)
Hum Brain Mapp (ISSN: 1065-9471, 1097-0193electronic, 1065-9471linking), 2011 Oct; 32(10): 1626-1636.
Impact Factor: 5.88
Dettagli Esporta in BibTeX Esporta in EndNote
Ocak M, Helbok A, Rangger C, Peitl PK, Nock BA, Morelli G, Eek A, Sosabowskijk, Breeman WA, Reubi JC, Decristoforo C
* Comparison of biological stability and metabolism of CCK2 receptor targeting peptides, a collaborative project under COST BM0607 (571 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2011 Sep; 38(8): 1426-1435.
Impact Factor: 4.991
Dettagli Esporta in BibTeX Esporta in EndNote
Varnäs K, Nyberg S, Halldin C, Varrone A, Takano A, Karlsson P, Andersson J, McCarthy D, Smith M, Pierson ME, Söderström J, Farde L
* Quantitative analysis of [11C]AZ10419369 binding to 5-HT 1B receptors in human brain (382 visite)
J Cereb Blood Flow Metab (ISSN: 0271-678x), 2011 Jan; 31(1): 113-123.
Impact Factor: 5.008
Dettagli Esporta in BibTeX Esporta in EndNote
Ciccarelli M, Sorriento D, Cipolletta E, Santulli G, Fusco A, Zhou R-H, Eckhart AD, Peppel K, Koch WJ, Trimarco B, Iaccarino G
* Impaired neoangiogenesis in β2-adrenoceptor gene-deficient mice: Restoration by intravascular human β2-adrenoceptor gene transfer and role of NFkB and CREB transcription factors (342 visite)
Br J Pharmacol British Journal Of Pharmacology (ISSN: 0007-1188), 2011; 162(3): 712-721.
Impact Factor: 4.409
Dettagli Esporta in BibTeX Esporta in EndNote
Nag S, Lehmann L, Kettschau G, Thiele A, Varrone A, Gulyas B, Halldin C
* Synthesis and evaluation of [F-18]fluororasagiline, a novel PET radioligand for MAO-B (277 visite)
Journal Of Labelled Compounds & Radiopharmaceuticals (ISSN: 0362-4803), 2011; 54: N/D-N/D.
Impact Factor: 1.429
Dettagli Esporta in BibTeX Esporta in EndNote
Varrone A, Halldin C
Molecular imaging of the dopamine transporter (505 visite)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 2010 Sep 1; 51(9): 1331-1334.
Impact Factor: 7.022
Dettagli Esporta in BibTeX Esporta in EndNote
Finnema SJ, Varrone A, Hwang TJ, Gulyas B, Pierson ME, Halldin C, Farde L
* Fenfluramine-induced serotonin release decreases [11C]AZ10419369 binding to 5-HT1B-receptors in the primate brain (318 visite)
Synapse (ISSN: 0887-4476), 2010 Jul; 64(7): 573-577.
Impact Factor: 2.925
Dettagli Esporta in BibTeX Esporta in EndNote
Varrone A, Sjoholm N, Eriksson L, Gulyas B, Halldin C, Farde L
* Advancement in PET quantification using 3D-OP-OSEM point spread function reconstruction with the HRRT (348 visite) (PDF 248 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2009 Oct; 36(10): 1639-1650.
Impact Factor: 4.531
Dettagli Esporta in BibTeX Esporta in EndNote
Varrone A, Steiger C, Schou M, Takano A, Finnema SJ, Guilloteau D, Gulyas B, Halldin C
* In vitro autoradiography and in vivo evaluation in cynomolgus monkey of [18F]FE-PE2I, a new dopamine transporter PET radioligand (431 visite)
Synapse (ISSN: 0887-4476), 2009 Oct; 63(10): 871-880.
Impact Factor: 2.557
Dettagli Esporta in BibTeX Esporta in EndNote
Takano A, Gulyas B, Varrone A, Maguire RP, Halldin C
* Saturated norepinephrine transporter occupancy by atomoxetine relevant to clinical doses: A rhesus monkey study with (S, S)-[18F]FMeNER-D (347 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2009 Sep; 36(8): 1308-1314.
Impact Factor: 4.531
Dettagli Esporta in BibTeX Esporta in EndNote
Vergote J, Chalon S, Emond P, Vercouillie J, Pappata S, Guilloteau D
* New SPECT and PET dementia tracers (321 visite)
Med Nucl (ISSN: 0928-1258), 2009 Mar; 33(3): 137-141.
Impact Factor: 0.155
Dettagli Esporta in BibTeX Esporta in EndNote
Takano A, Varrone A, Gulyas B, Karlsson P, Tauscher J, Halldin C
* Mapping of the norepinephrine transporter in man using PET with (S, S)-[F-18]FMeNER-D-2 (270 visite) (PDF 200 visite)
Neuroimage (ISSN: 1053-8119, 1053-8119linking), 2008 Sep 15; 41: 474-482.
Impact Factor: 5.694
Dettagli Esporta in BibTeX Esporta in EndNote
Takano A, Halldin C, Varrone A, Karlsson P, Sjoholm N, Stubbs JB, Schou M, Airaksinen AJ, Tauscher J, Gulyas B
* Biodistribution and radiation dosimetry of the norepinephrine transporter radioligand (S, S)-[18F]FMeNER-D2: A human whole-body PET study (237 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2008 Mar; 35(3): 630-636.
Impact Factor: 4.532
Dettagli Esporta in BibTeX Esporta in EndNote
Takano A, Gulyas B, Varrone A, Karlsson P, Schou M, Airaksinen AJ, Vandenhende F, Tauscher J, Halldin C
* Imaging the norepinephrine transporter with positron emission tomography: Initial human studies with (S, S)-[18F]FMeNER-D2 (288 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2008 Jan; 35(1): 153-157.
Impact Factor: 4.532
Dettagli Esporta in BibTeX Esporta in EndNote
Del Gatto A, Zaccaro L, Grieco P, Novellino E, Zannetti A, Del Vecchio S, Iommelli F, Salvatore M, Pedone C, Saviano M
* Novel And Selective Alpha (v) Beta3 Receptor Peptide Antagonist: Design, Synthesis, And Biological Behavior (529 visite)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2006 Jun 1; 49(11): 3416-3420.
Impact Factor: 5.115
Dettagli Esporta in BibTeX Esporta in EndNote
Hirst WD, Abrahamsen B, Blaney FE, Calver AR, Aloj L, Price GW, Medhurst AD
* Differences In The Central Nervous System Distribution And Pharmacology Of The Mouse 5-Hydroxytryptamine-6 Receptor Compared With Rat And Human Receptors Investigated By Radioligand Binding, Site-Directed Mutagenesis, And Molecular Modeling (259 visite)
Molecular Pharmacology, 2003; 64: 1295-1308.
Impact Factor: 4.12
Dettagli Esporta in BibTeX Esporta in EndNote
19 Records (18 escludendo Abstract e Conferenze).
Impact factor totale: 79.775 (78.346 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 81.742 (80.848 escludendo Abstract e Conferenze).
Vai a fine pagina Versione per copia e incolla facile Esporta tutto in BibTeX Esporta tutto in EndNote
Quarantelli M, Palladino O, Prinster A, Schiavone V, Carotenuto B, Brunetti A, Marsili A, Casiello M, Muscettola G, Salvatore M, De Bartolomeis A
* Patients with poor response to antipsychotics have a more severe pattern of frontal atrophy: a voxel-based morphometry study of treatment resistance in schizophrenia (300 visite)
Biomed Res Int (ISSN: 2314-6133, 2314-6141, 2314-6141electronic), 2014; 2014: 325052-325052.
Impact Factor: 1.579
Dettagli Esporta in BibTeX Esporta in EndNote
Sasaki T, Ito H, Kimura Y, Arakawa R, Takano H, Seki C, Kodaka F, Fujie S, Takahata K, Nogami T, Suzuki M, Fujiwara H, Takahashi H, Nakao R, Fukumura T, Varrone A, Halldin C, Nishikawa T, Suhara T
* Quantification of dopamine transporter in human brain using PET with 18F-FE-PE2I (379 visite)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 2012 Jul; 53(7): 1065-1073.
Impact Factor: 5.774
Dettagli Esporta in BibTeX Esporta in EndNote
Takano A, Gulyas B, Varrone A, Karlsson P, Sjoholm N, Larsson S, Jonsson C, Odh R, Sparks R, Al Tawil N, Hoffmann A, Zimmermann T, Thiele A, Halldin C
* Biodistribution and radiation dosimetry of the 18 kDa translocator protein (TSPO) radioligand [ 18F]FEDAA1106: A human whole-body PET study (398 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2011 Nov; 38(11): 2058-2065.
Impact Factor: 4.991
Dettagli Esporta in BibTeX Esporta in EndNote
Esmaeilzadeh M, Farde L, Karlsson P, Varrone A, Halldin C, Waters S, Tedroff J
* Extrastriatal dopamine D 2 receptor binding in Huntington's disease (412 visite)
Hum Brain Mapp (ISSN: 1065-9471, 1097-0193electronic, 1065-9471linking), 2011 Oct; 32(10): 1626-1636.
Impact Factor: 5.88
Dettagli Esporta in BibTeX Esporta in EndNote
Ocak M, Helbok A, Rangger C, Peitl PK, Nock BA, Morelli G, Eek A, Sosabowskijk, Breeman WA, Reubi JC, Decristoforo C
* Comparison of biological stability and metabolism of CCK2 receptor targeting peptides, a collaborative project under COST BM0607 (571 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2011 Sep; 38(8): 1426-1435.
Impact Factor: 4.991
Dettagli Esporta in BibTeX Esporta in EndNote
Varnäs K, Nyberg S, Halldin C, Varrone A, Takano A, Karlsson P, Andersson J, McCarthy D, Smith M, Pierson ME, Söderström J, Farde L
* Quantitative analysis of [11C]AZ10419369 binding to 5-HT 1B receptors in human brain (382 visite)
J Cereb Blood Flow Metab (ISSN: 0271-678x), 2011 Jan; 31(1): 113-123.
Impact Factor: 5.008
Dettagli Esporta in BibTeX Esporta in EndNote
Ciccarelli M, Sorriento D, Cipolletta E, Santulli G, Fusco A, Zhou R-H, Eckhart AD, Peppel K, Koch WJ, Trimarco B, Iaccarino G
* Impaired neoangiogenesis in β2-adrenoceptor gene-deficient mice: Restoration by intravascular human β2-adrenoceptor gene transfer and role of NFkB and CREB transcription factors (342 visite)
Br J Pharmacol British Journal Of Pharmacology (ISSN: 0007-1188), 2011; 162(3): 712-721.
Impact Factor: 4.409
Dettagli Esporta in BibTeX Esporta in EndNote
Nag S, Lehmann L, Kettschau G, Thiele A, Varrone A, Gulyas B, Halldin C
* Synthesis and evaluation of [F-18]fluororasagiline, a novel PET radioligand for MAO-B (277 visite)
Journal Of Labelled Compounds & Radiopharmaceuticals (ISSN: 0362-4803), 2011; 54: N/D-N/D.
Impact Factor: 1.429
Dettagli Esporta in BibTeX Esporta in EndNote
Varrone A, Halldin C
Molecular imaging of the dopamine transporter (505 visite)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 2010 Sep 1; 51(9): 1331-1334.
Impact Factor: 7.022
Dettagli Esporta in BibTeX Esporta in EndNote
Finnema SJ, Varrone A, Hwang TJ, Gulyas B, Pierson ME, Halldin C, Farde L
* Fenfluramine-induced serotonin release decreases [11C]AZ10419369 binding to 5-HT1B-receptors in the primate brain (318 visite)
Synapse (ISSN: 0887-4476), 2010 Jul; 64(7): 573-577.
Impact Factor: 2.925
Dettagli Esporta in BibTeX Esporta in EndNote
Varrone A, Sjoholm N, Eriksson L, Gulyas B, Halldin C, Farde L
* Advancement in PET quantification using 3D-OP-OSEM point spread function reconstruction with the HRRT (348 visite) (PDF 248 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2009 Oct; 36(10): 1639-1650.
Impact Factor: 4.531
Dettagli Esporta in BibTeX Esporta in EndNote
Varrone A, Steiger C, Schou M, Takano A, Finnema SJ, Guilloteau D, Gulyas B, Halldin C
* In vitro autoradiography and in vivo evaluation in cynomolgus monkey of [18F]FE-PE2I, a new dopamine transporter PET radioligand (431 visite)
Synapse (ISSN: 0887-4476), 2009 Oct; 63(10): 871-880.
Impact Factor: 2.557
Dettagli Esporta in BibTeX Esporta in EndNote
Takano A, Gulyas B, Varrone A, Maguire RP, Halldin C
* Saturated norepinephrine transporter occupancy by atomoxetine relevant to clinical doses: A rhesus monkey study with (S, S)-[18F]FMeNER-D (347 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2009 Sep; 36(8): 1308-1314.
Impact Factor: 4.531
Dettagli Esporta in BibTeX Esporta in EndNote
Vergote J, Chalon S, Emond P, Vercouillie J, Pappata S, Guilloteau D
* New SPECT and PET dementia tracers (321 visite)
Med Nucl (ISSN: 0928-1258), 2009 Mar; 33(3): 137-141.
Impact Factor: 0.155
Dettagli Esporta in BibTeX Esporta in EndNote
Takano A, Varrone A, Gulyas B, Karlsson P, Tauscher J, Halldin C
* Mapping of the norepinephrine transporter in man using PET with (S, S)-[F-18]FMeNER-D-2 (270 visite) (PDF 200 visite)
Neuroimage (ISSN: 1053-8119, 1053-8119linking), 2008 Sep 15; 41: 474-482.
Impact Factor: 5.694
Dettagli Esporta in BibTeX Esporta in EndNote
Takano A, Halldin C, Varrone A, Karlsson P, Sjoholm N, Stubbs JB, Schou M, Airaksinen AJ, Tauscher J, Gulyas B
* Biodistribution and radiation dosimetry of the norepinephrine transporter radioligand (S, S)-[18F]FMeNER-D2: A human whole-body PET study (237 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2008 Mar; 35(3): 630-636.
Impact Factor: 4.532
Dettagli Esporta in BibTeX Esporta in EndNote
Takano A, Gulyas B, Varrone A, Karlsson P, Schou M, Airaksinen AJ, Vandenhende F, Tauscher J, Halldin C
* Imaging the norepinephrine transporter with positron emission tomography: Initial human studies with (S, S)-[18F]FMeNER-D2 (288 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2008 Jan; 35(1): 153-157.
Impact Factor: 4.532
Dettagli Esporta in BibTeX Esporta in EndNote
Del Gatto A, Zaccaro L, Grieco P, Novellino E, Zannetti A, Del Vecchio S, Iommelli F, Salvatore M, Pedone C, Saviano M
* Novel And Selective Alpha (v) Beta3 Receptor Peptide Antagonist: Design, Synthesis, And Biological Behavior (529 visite)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2006 Jun 1; 49(11): 3416-3420.
Impact Factor: 5.115
Dettagli Esporta in BibTeX Esporta in EndNote
Hirst WD, Abrahamsen B, Blaney FE, Calver AR, Aloj L, Price GW, Medhurst AD
* Differences In The Central Nervous System Distribution And Pharmacology Of The Mouse 5-Hydroxytryptamine-6 Receptor Compared With Rat And Human Receptors Investigated By Radioligand Binding, Site-Directed Mutagenesis, And Molecular Modeling (259 visite)
Molecular Pharmacology, 2003; 64: 1295-1308.
Impact Factor: 4.12
Dettagli Esporta in BibTeX Esporta in EndNote
19 Records (18 escludendo Abstract e Conferenze).
Impact factor totale: 79.775 (78.346 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 81.742 (80.848 escludendo Abstract e Conferenze).
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