Sex differences in the serotonin 1A receptor and serotonin transporter binding in the human brain measured by PET (490 views)
Neuroimage (ISSN: 1053-8119, 1053-8119linking), 2008 Feb 1; 39(3): 1408-1419.
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Paper type: Journal Article,
Impact factor: 5.694, 5-year impact factor: 6.884
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-37849032647&partnerID=40&md5=7463ebc39caf5e3369767ce135f902cb
Keywords: Carbon 11, N [2 [4 (2 Methoxyphenyl) 1 Piperazinyl]ethyl] N (2 Pyridyl)cyclohexanecarboxamide, Radioligand, Serotonin 1a Receptor, Serotonin Transporter, Serotonin Uptake Inhibitor, Adult, Anxiety, Article, Brain Size, Depression, Dorsal Raphe Nucleus, Female, Hippocampus, Human, Human Experiment, In Vivo Study, Neocortex, Normal Human, Nuclear Magnetic Resonance Imaging, Positron Emission Tomography, Priority Journal, Quantitative Analysis, Receptor Binding, Serotoninergic System, Sex Difference, Statistical Analysis, Suicide, Benzylamines, Biological Markers, Brain Chemistry, Cerebral Cortex, Image Processing, Computer-Assisted, Positron-Emission Tomography, Protein Binding, Pyridines, Radiopharmaceuticals, 5-Ht1a, Serotonin Antagonists, Serotonin Plasma Membrane Transport Proteins, Sex Characteristics, N [2 [4 (2 Methoxyphenyl) 1 Piperazinyl] Ethyl] N (2 Pyridyl) Cyclohexanecarboxamide,
Affiliations:
*** IBB - CNR ***
Karolinska Institutet, Department of Clinical Neuroscience, Psychiatry Section, Stockholm, Sweden
References:
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Arora, R. C., Meltzer, H. Y., 3H-imipramine binding in the frontal cortex of suicides (1989) Psychiatry Res., 30, pp. 125-135
Bremner, J. D., Bronen, R. A., De Erasquin, G., Vermetten, E., Staib, L. H., Ng, C. K., Soufer, R., Innis, R. B., Development and reliability of a method for using magnetic resonance imaging for the definition of regions of interest for positron emission tomography (1998) Clin. Positron Imaging, 1, pp. 145-159
Cosgrove, K. P., Mazure, C. M., Staley, J. K., Evolving Knowledge of Sex Differences in Brain Structure, Function, and Chemistry (2007) Biol. Psychiatry, 62, pp. 847-855
David, S. P., Murthy, N. V., Rabiner, E. A., A functional genetic variation of the serotonin (5-HT) transporter affects 5-HT1A receptor binding in humans (2005) J. Neurosci., 25, pp. 2586-2590
Drevets, W. C., Frank, E., Price, J. C., Kupfer, D. J., Holt, D., Greer, P. J., Huang, Y., Mathis, C., PET imaging of serotonin 1A receptor binding in depression (1999) Biol. Psychiatry, 46, pp. 1375-1387
Epperson, C. N., Haga, K., Mason, G. F., Sellers, E., Gueorguieva, R., Zhang, W., Weiss, E., Krystal, J. H., Cortical gamma-aminobutyric acid levels across the menstrual cycle in healthy women and those with premenstrual dysphoric disorder: a proton magnetic resonance spectroscopy study (2002) Arch. Gen. Psychiatry, 59, pp. 851-858
Frankle, W. G., Huang, Y., Hwang, D. R., Talbot, P. S., Slifstein, M., Van Heertum, R., Abi-Dargham, A., Laruelle, M., Comparative evaluation of serotonin transporter radioligands 11C-DASB and 11C-McN 5652 in healthy humans (2004) J. Nucl. Med., 45, pp. 682-694
Friston, K. J., Holms, A. P., Worsley, K. J., Poline, J. B., Frith, C., Frackowiak, R. S. J., Statistical parametric maps in functional imaging: a general linear approach (1995) Hum. Brain Mapp., 2, pp. 189-210
Gorman, J. M., Gender differences in depression and response to psychotropic medication (2006) Gend. Med., 3, pp. 93-109
Gottfries, C. G., Roos, B. E., Winblad, B., Determination of 5-hydroxytryptamine, 5-hydroxyindoleacetic acid and homovanillic acid in brain tissue from an autopsy material (1974) Acta Psychiatr. Scand., 50, pp. 496-507
Gunn, R. N., Lammertsma, A. A., Hume, S. P., Cunningham, V. J., Parametric imaging of ligand-receptor binding in PET using a simplified reference region model (1997) NeuroImage, 6, pp. 279-287
Gunn, R. N., Sargent, P. A., Bench, C. J., Rabiner, E. A., Osman, S., Pike, V. W., Hume, S. P., Lammertsma, A. A., Tracer kinetic modeling of the 5-HT1A receptor ligand [carbonyl-11C] WAY-100635 for PET (1998) NeuroImage, 8, pp. 426-440
Kendler, K. S., Thornton, L. M., Gardner, C. O., Stressful life events and previous episodes in the etiology of major depression in women: an evaluation of the "kindling" hypothesis (2000) Am. J. Psychiatry, 157, pp. 1243-1251
Kessler, R. C., McGonagle, K. A., Swartz, M., Blazer, D. G., Nelson, C. B., Sex and depression in the National Comorbidity Survey. I: Lifetime prevalence, chronicity and recurrence (1993) J. Affect. Disord., 29, pp. 85-96
Krasikova, R. N., Truong, P., Halldin, C., A fully automated production of [carbolyl-11C] WAY-10035 for clinical PET studies (2003) J. Label. Compd. Radiopharm., 46, p. 244
Lesch, K. P., Bengel, D., Heils, A., Sabol, S. Z., Greenberg, B. D., Petri, S., Benjamin, J., Murphy, D. L., Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region (1996) Science, 274, pp. 1527-1531
Lewinsohn, P. M., Rohde, P., Seeley, J. R., Baldwin, C. L., Gender differences in suicide attempts from adolescence to young adulthood (2001) J. Am. Acad. Child Adolesc. Psych., 40, pp. 427-434
Madeira, M. D., Lieberman, A. R., Sexual dimorphism in the mammalian limbic system (1995) Prog. Neurobiol., 45, pp. 275-333
Moses, E. L., Drevets, W. C., Smith, G., Mathis, C. A., Kalro, B. N., Butters, M. A., Leondires, M. P., Berga, S. L., Effects of estradiol and progesterone administration on human serotonin 2A receptor binding: a PET study (2000) Biol. Psychiatry, 48, pp. 854-860
Parsey, R. V., Oquendo, M. A., Simpson, N. R., Ogden, R. T., Van Heertum, R., Arango, V., Mann, J. J., Effects of sex, age, and aggressive traits in man on brain serotonin 5-HT1A receptor binding potential measured by PET using [C-11] WAY-100635 (2002) Brain Res., 954, pp. 173-182
Parsey, R. V., Arango, V., Olvet, D. M., Oquendo, M. A., Van Heertum, R. L., Mann, J. J., Regional heterogeneity of 5-HT1A receptors in human cerebellum as assessed by positron emission tomography (2005) J. Cereb. Blood Flow Metab., 25, pp. 785-793
Parsey, R. V., Hastings, R. S., Oquendo, M. A., Huang, Y. Y., Simpson, N., Arcement, J., Huang, Y., Mann, J. J., Lower serotonin transporter binding potential in the human brain during major depressive episodes (2006) Am. J. Psychiatry, 163, pp. 52-58
Parsey, R. V., Olvet, D. M., Oquendo, M. A., Huang, Y. Y., Ogden, R. T., Mann, J. J., Higher 5-HT1A receptor binding potential during a major depressive episode predicts poor treatment response: preliminary data from a naturalistic study (2006) Neuropsychopharmacology, 31, pp. 1745-1749
Pigott, T. A., Gender differences in the epidemiology and treatment of anxiety disorders (1999) J. Clin. Psychiatry, 60 (SUPPL. 18), pp. 4-15
Pugliese, A. M., Passani, M. B., Corradetti, R., Effect of the selective 5-HT1A receptor antagonist WAY 100635 on the inhibition of e. p. s. ps produced by 5-HT in the CA1 region of rat hippocampal slices (1998) Br. J. Pharmacol., 124, pp. 93-100
Reiman, E. M., Armstrong, S. M., Matt, K. S., Mattox, J. H., The application of positron emission tomography to the study of the normal menstrual cycle (1996) Hum. Reprod., 11, pp. 2799-2805
Rosecrans, J. A., Differences in brain area 5-hydroxytryptamine turnover and rearing behavior in rats and mice of both sexes (1970) Eur. J. Pharmacol., 9, pp. 379-382
Rousset, O. G., Ma, Y., Evans, A. C., Correction for partial volume effects in PET: principle and validation (1998) J. Nucl. Med., 39, pp. 904-911
Sargent, P. A., Kjaer, K. H., Bench, C. J., Rabiner, E. A., Messa, C., Meyer, J., Gunn, R. N., Cowen, P. J., Brain serotonin1A receptor binding measured by positron emission tomography with [11C] WAY-100635: effects of depression and antidepressant treatment (2000) Arch. Gen. Psychiatry, 57, pp. 174-180
Staley, J. K., Krishnan-Sarin, S., Zoghbi, S., Tamagnan, G., Fujita, M., Seibyl, J. P., Maciejewski, P. K., Innis, R. B., Sex differences in [123I] beta-CIT SPECT measures of dopamine and serotonin transporter availability in healthy smokers and nonsmokers (2001) Synapse, 41, pp. 275-284
Staley, J. K., Sanacora, G., Tamagnan, G., Maciejewski, P. K., Malison, R. T., Berman, R. M., Vythilingam, M., Innis, R. B., Sex differences in diencephalon serotonin transporter availability in major depression (2006) Biol. Psychiatry, 59, pp. 40-47
Turner, M. R., Rabiner, E. A., Hammers, A., Al-Chalabi, A., Grasby, P. M., Shaw, C. E., Brooks, D. J., Leigh, P. N., [11C] -WAY100635 PET demonstrates marked 5-HT1A receptor changes in sporadic ALS (2005) Brain, 128, pp. 896-905
van Dyck, C. H., Malison, R. T., Staley, J. K., Jacobsen, L. K., Seibyl, J. P., Laruelle, M., Baldwin, R. M., Gelernter, J., Central serotonin transporter availability measured with [123I] beta-CIT SPECT in relation to serotonin transporter genotype (2004) Am. J. Psychiatry, 161, pp. 525-531
Weiss, L. A., Pan, L., Abney, M., Ober, C., The sex-specific genetic architecture of quantitative traits in humans (2006) Nat. Genet., 38, pp. 218-222
Young, S. N., Gauthier, S., Anderson, G. M., Purdy, W. C., Tryptophan, 5-hydroxyindoleacetic acid and indoleacetic acid in human cerebrospinal fluid: interrelationships and the influence of age, sex, epilepsy and anticonvulsant drugs (1980) J. Neurol., Neurosurg. Psychiatry, 43, pp. 438-445
Neuroimage (ISSN: 1053-8119, 1053-8119linking), 2008 Feb 1; 39(3): 1408-1419.
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Paper type: Journal Article,
Impact factor: 5.694, 5-year impact factor: 6.884
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-37849032647&partnerID=40&md5=7463ebc39caf5e3369767ce135f902cb
Keywords: Carbon 11, N [2 [4 (2 Methoxyphenyl) 1 Piperazinyl]ethyl] N (2 Pyridyl)cyclohexanecarboxamide, Radioligand, Serotonin 1a Receptor, Serotonin Transporter, Serotonin Uptake Inhibitor, Adult, Anxiety, Article, Brain Size, Depression, Dorsal Raphe Nucleus, Female, Hippocampus, Human, Human Experiment, In Vivo Study, Neocortex, Normal Human, Nuclear Magnetic Resonance Imaging, Positron Emission Tomography, Priority Journal, Quantitative Analysis, Receptor Binding, Serotoninergic System, Sex Difference, Statistical Analysis, Suicide, Benzylamines, Biological Markers, Brain Chemistry, Cerebral Cortex, Image Processing, Computer-Assisted, Positron-Emission Tomography, Protein Binding, Pyridines, Radiopharmaceuticals, 5-Ht1a, Serotonin Antagonists, Serotonin Plasma Membrane Transport Proteins, Sex Characteristics, N [2 [4 (2 Methoxyphenyl) 1 Piperazinyl] Ethyl] N (2 Pyridyl) Cyclohexanecarboxamide,
Affiliations:
*** IBB - CNR ***
Karolinska Institutet, Department of Clinical Neuroscience, Psychiatry Section, Stockholm, Sweden
References:
Agren, H., Mefford, I.N., Rudorfer, M.V., Linnoila, M., Potter, W.Z., Interacting neurotransmitter systems. A non-experimental approach to the 5HIAA-HVA correlation in human CSF (1986) J. Psychiatr. Res., 20, pp. 175-19
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Lesch, K. P., Bengel, D., Heils, A., Sabol, S. Z., Greenberg, B. D., Petri, S., Benjamin, J., Murphy, D. L., Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region (1996) Science, 274, pp. 1527-1531
Lewinsohn, P. M., Rohde, P., Seeley, J. R., Baldwin, C. L., Gender differences in suicide attempts from adolescence to young adulthood (2001) J. Am. Acad. Child Adolesc. Psych., 40, pp. 427-434
Madeira, M. D., Lieberman, A. R., Sexual dimorphism in the mammalian limbic system (1995) Prog. Neurobiol., 45, pp. 275-333
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Parsey, R. V., Oquendo, M. A., Simpson, N. R., Ogden, R. T., Van Heertum, R., Arango, V., Mann, J. J., Effects of sex, age, and aggressive traits in man on brain serotonin 5-HT1A receptor binding potential measured by PET using [C-11] WAY-100635 (2002) Brain Res., 954, pp. 173-182
Parsey, R. V., Arango, V., Olvet, D. M., Oquendo, M. A., Van Heertum, R. L., Mann, J. J., Regional heterogeneity of 5-HT1A receptors in human cerebellum as assessed by positron emission tomography (2005) J. Cereb. Blood Flow Metab., 25, pp. 785-793
Parsey, R. V., Hastings, R. S., Oquendo, M. A., Huang, Y. Y., Simpson, N., Arcement, J., Huang, Y., Mann, J. J., Lower serotonin transporter binding potential in the human brain during major depressive episodes (2006) Am. J. Psychiatry, 163, pp. 52-58
Parsey, R. V., Olvet, D. M., Oquendo, M. A., Huang, Y. Y., Ogden, R. T., Mann, J. J., Higher 5-HT1A receptor binding potential during a major depressive episode predicts poor treatment response: preliminary data from a naturalistic study (2006) Neuropsychopharmacology, 31, pp. 1745-1749
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Rousset, O. G., Ma, Y., Evans, A. C., Correction for partial volume effects in PET: principle and validation (1998) J. Nucl. Med., 39, pp. 904-911
Sargent, P. A., Kjaer, K. H., Bench, C. J., Rabiner, E. A., Messa, C., Meyer, J., Gunn, R. N., Cowen, P. J., Brain serotonin1A receptor binding measured by positron emission tomography with [11C] WAY-100635: effects of depression and antidepressant treatment (2000) Arch. Gen. Psychiatry, 57, pp. 174-180
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Staley, J. K., Sanacora, G., Tamagnan, G., Maciejewski, P. K., Malison, R. T., Berman, R. M., Vythilingam, M., Innis, R. B., Sex differences in diencephalon serotonin transporter availability in major depression (2006) Biol. Psychiatry, 59, pp. 40-47
Turner, M. R., Rabiner, E. A., Hammers, A., Al-Chalabi, A., Grasby, P. M., Shaw, C. E., Brooks, D. J., Leigh, P. N., [11C] -WAY100635 PET demonstrates marked 5-HT1A receptor changes in sporadic ALS (2005) Brain, 128, pp. 896-905
van Dyck, C. H., Malison, R. T., Staley, J. K., Jacobsen, L. K., Seibyl, J. P., Laruelle, M., Baldwin, R. M., Gelernter, J., Central serotonin transporter availability measured with [123I] beta-CIT SPECT in relation to serotonin transporter genotype (2004) Am. J. Psychiatry, 161, pp. 525-531
Weiss, L. A., Pan, L., Abney, M., Ober, C., The sex-specific genetic architecture of quantitative traits in humans (2006) Nat. Genet., 38, pp. 218-222
Young, S. N., Gauthier, S., Anderson, G. M., Purdy, W. C., Tryptophan, 5-hydroxyindoleacetic acid and indoleacetic acid in human cerebrospinal fluid: interrelationships and the influence of age, sex, epilepsy and anticonvulsant drugs (1980) J. Neurol., Neurosurg. Psychiatry, 43, pp. 438-445
Sex differences in the serotonin 1A receptor and serotonin transporter binding in the human brain measured by PET
Women and men differ in serotonin associated psychiatric conditions, such as depression, anxiety and suicide. Despite this, very few studies focus on sex differences in the serotonin system. Of the biomarkers in the serotonin system, serotonin1A (5-HT1A) receptor is implicated in depression, and anxiety and serotonin transporter (5-HTT) is a target for selective serotonin reuptake inhibitors, psychotropic drugs used in the treatment of these disorders. The objective of the present study was to study sex related differences in the 5-HT1A receptor and 5-HTT binding potentials (BPNDs) in healthy humans, in vivo. Positron emission tomography and selective radioligands [11C]WAY100635 and [11C]MADAM were used to evaluate binding potentials for 5-HT1A receptors (14 women and 14 men) and 5-HTT (8 women and 10 men). The binding potentials were estimated both on the level of anatomical regions and voxel wise, derived by the simplified reference tissue model and wavelet/Logan plot parametric image techniques respectively. Compared to men, women had significantly higher 5-HT1A receptor and lower 5-HTT binding potentials in a wide array of cortical and subcortical brain regions. In women, there was a positive correlation between 5-HT1A receptor and 5-HTT binding potentials for the region of hippocampus. Sex differences in 5-HT1A receptor and 5-HTT BPND may reflect biological distinctions in the serotonin system contributing to sex differences in the prevalence of psychiatric disorders such as depression and anxiety. The result of the present study may help in understanding sex differences in drug treatment responses to drugs affecting the serotonin system. © 2007 Elsevier Inc. All rights reserved.
Women and men differ in serotonin associated psychiatric conditions, such as depression, anxiety and suicide. Despite this, very few studies focus on sex differences in the serotonin system. Of the biomarkers in the serotonin system, serotonin1A (5-HT1A) receptor is implicated in depression, and anxiety and serotonin transporter (5-HTT) is a target for selective serotonin reuptake inhibitors, psychotropic drugs used in the treatment of these disorders. The objective of the present study was to study sex related differences in the 5-HT1A receptor and 5-HTT binding potentials (BPNDs) in healthy humans, in vivo. Positron emission tomography and selective radioligands [11C]WAY100635 and [11C]MADAM were used to evaluate binding potentials for 5-HT1A receptors (14 women and 14 men) and 5-HTT (8 women and 10 men). The binding potentials were estimated both on the level of anatomical regions and voxel wise, derived by the simplified reference tissue model and wavelet/Logan plot parametric image techniques respectively. Compared to men, women had significantly higher 5-HT1A receptor and lower 5-HTT binding potentials in a wide array of cortical and subcortical brain regions. In women, there was a positive correlation between 5-HT1A receptor and 5-HTT binding potentials for the region of hippocampus. Sex differences in 5-HT1A receptor and 5-HTT BPND may reflect biological distinctions in the serotonin system contributing to sex differences in the prevalence of psychiatric disorders such as depression and anxiety. The result of the present study may help in understanding sex differences in drug treatment responses to drugs affecting the serotonin system. © 2007 Elsevier Inc. All rights reserved.
Sex differences in the serotonin 1A receptor and serotonin transporter binding in the human brain measured by PET
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Sex differences in the serotonin 1A receptor and serotonin transporter binding in the human brain measured by PET
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Quarantelli M, Palladino O, Prinster A, Schiavone V, Carotenuto B, Brunetti A, Marsili A, Casiello M, Muscettola G, Salvatore M, De Bartolomeis A
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Sasaki T, Ito H, Kimura Y, Arakawa R, Takano H, Seki C, Kodaka F, Fujie S, Takahata K, Nogami T, Suzuki M, Fujiwara H, Takahashi H, Nakao R, Fukumura T, Varrone A, Halldin C, Nishikawa T, Suhara T
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Takano A, Gulyas B, Varrone A, Karlsson P, Sjoholm N, Larsson S, Jonsson C, Odh R, Sparks R, Al Tawil N, Hoffmann A, Zimmermann T, Thiele A, Halldin C
* Biodistribution and radiation dosimetry of the 18 kDa translocator protein (TSPO) radioligand [ 18F]FEDAA1106: A human whole-body PET study (419 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2011 Nov; 38(11): 2058-2065.
Impact Factor: 4.991
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Esmaeilzadeh M, Farde L, Karlsson P, Varrone A, Halldin C, Waters S, Tedroff J
* Extrastriatal dopamine D 2 receptor binding in Huntington's disease (462 views)
Hum Brain Mapp (ISSN: 1065-9471, 1097-0193electronic, 1065-9471linking), 2011 Oct; 32(10): 1626-1636.
Impact Factor: 5.88
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Ocak M, Helbok A, Rangger C, Peitl PK, Nock BA, Morelli G, Eek A, Sosabowskijk, Breeman WA, Reubi JC, Decristoforo C
* Comparison of biological stability and metabolism of CCK2 receptor targeting peptides, a collaborative project under COST BM0607 (692 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2011 Sep; 38(8): 1426-1435.
Impact Factor: 4.991
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Varnäs K, Nyberg S, Halldin C, Varrone A, Takano A, Karlsson P, Andersson J, McCarthy D, Smith M, Pierson ME, Söderström J, Farde L
* Quantitative analysis of [11C]AZ10419369 binding to 5-HT 1B receptors in human brain (412 views)
J Cereb Blood Flow Metab (ISSN: 0271-678x), 2011 Jan; 31(1): 113-123.
Impact Factor: 5.008
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Ciccarelli M, Sorriento D, Cipolletta E, Santulli G, Fusco A, Zhou R-H, Eckhart AD, Peppel K, Koch WJ, Trimarco B, Iaccarino G
* Impaired neoangiogenesis in β2-adrenoceptor gene-deficient mice: Restoration by intravascular human β2-adrenoceptor gene transfer and role of NFkB and CREB transcription factors (367 views)
Br J Pharmacol British Journal Of Pharmacology (ISSN: 0007-1188), 2011; 162(3): 712-721.
Impact Factor: 4.409
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Nag S, Lehmann L, Kettschau G, Thiele A, Varrone A, Gulyas B, Halldin C
* Synthesis and evaluation of [F-18]fluororasagiline, a novel PET radioligand for MAO-B (289 views)
Journal Of Labelled Compounds & Radiopharmaceuticals (ISSN: 0362-4803), 2011; 54: N/D-N/D.
Impact Factor: 1.429
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Varrone A, Halldin C
Molecular imaging of the dopamine transporter (527 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 2010 Sep 1; 51(9): 1331-1334.
Impact Factor: 7.022
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Finnema SJ, Varrone A, Hwang TJ, Gulyas B, Pierson ME, Halldin C, Farde L
* Fenfluramine-induced serotonin release decreases [11C]AZ10419369 binding to 5-HT1B-receptors in the primate brain (349 views)
Synapse (ISSN: 0887-4476), 2010 Jul; 64(7): 573-577.
Impact Factor: 2.925
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Varrone A, Sjoholm N, Eriksson L, Gulyas B, Halldin C, Farde L
* Advancement in PET quantification using 3D-OP-OSEM point spread function reconstruction with the HRRT (517 views) (PDF 258 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2009 Oct; 36(10): 1639-1650.
Impact Factor: 4.531
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Varrone A, Steiger C, Schou M, Takano A, Finnema SJ, Guilloteau D, Gulyas B, Halldin C
* In vitro autoradiography and in vivo evaluation in cynomolgus monkey of [18F]FE-PE2I, a new dopamine transporter PET radioligand (520 views)
Synapse (ISSN: 0887-4476), 2009 Oct; 63(10): 871-880.
Impact Factor: 2.557
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Takano A, Gulyas B, Varrone A, Maguire RP, Halldin C
* Saturated norepinephrine transporter occupancy by atomoxetine relevant to clinical doses: A rhesus monkey study with (S, S)-[18F]FMeNER-D (372 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2009 Sep; 36(8): 1308-1314.
Impact Factor: 4.531
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Vergote J, Chalon S, Emond P, Vercouillie J, Pappata S, Guilloteau D
* New SPECT and PET dementia tracers (358 views)
Med Nucl (ISSN: 0928-1258), 2009 Mar; 33(3): 137-141.
Impact Factor: 0.155
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Takano A, Varrone A, Gulyas B, Karlsson P, Tauscher J, Halldin C
* Mapping of the norepinephrine transporter in man using PET with (S, S)-[F-18]FMeNER-D-2 (292 views) (PDF 204 views)
Neuroimage (ISSN: 1053-8119, 1053-8119linking), 2008 Sep 15; 41: 474-482.
Impact Factor: 5.694
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Takano A, Halldin C, Varrone A, Karlsson P, Sjoholm N, Stubbs JB, Schou M, Airaksinen AJ, Tauscher J, Gulyas B
* Biodistribution and radiation dosimetry of the norepinephrine transporter radioligand (S, S)-[18F]FMeNER-D2: A human whole-body PET study (264 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2008 Mar; 35(3): 630-636.
Impact Factor: 4.532
View Export to BibTeX Export to EndNote
Takano A, Gulyas B, Varrone A, Karlsson P, Schou M, Airaksinen AJ, Vandenhende F, Tauscher J, Halldin C
* Imaging the norepinephrine transporter with positron emission tomography: Initial human studies with (S, S)-[18F]FMeNER-D2 (304 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2008 Jan; 35(1): 153-157.
Impact Factor: 4.532
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Del Gatto A, Zaccaro L, Grieco P, Novellino E, Zannetti A, Del Vecchio S, Iommelli F, Salvatore M, Pedone C, Saviano M
* Novel And Selective Alpha (v) Beta3 Receptor Peptide Antagonist: Design, Synthesis, And Biological Behavior (618 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2006 Jun 1; 49(11): 3416-3420.
Impact Factor: 5.115
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Hirst WD, Abrahamsen B, Blaney FE, Calver AR, Aloj L, Price GW, Medhurst AD
* Differences In The Central Nervous System Distribution And Pharmacology Of The Mouse 5-Hydroxytryptamine-6 Receptor Compared With Rat And Human Receptors Investigated By Radioligand Binding, Site-Directed Mutagenesis, And Molecular Modeling (272 views)
Molecular Pharmacology, 2003; 64: 1295-1308.
Impact Factor: 4.12
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* Patients with poor response to antipsychotics have a more severe pattern of frontal atrophy: a voxel-based morphometry study of treatment resistance in schizophrenia (331 views)
Biomed Res Int (ISSN: 2314-6133, 2314-6141, 2314-6141electronic), 2014; 2014: 325052-325052.
Impact Factor: 1.579
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Sasaki T, Ito H, Kimura Y, Arakawa R, Takano H, Seki C, Kodaka F, Fujie S, Takahata K, Nogami T, Suzuki M, Fujiwara H, Takahashi H, Nakao R, Fukumura T, Varrone A, Halldin C, Nishikawa T, Suhara T
* Quantification of dopamine transporter in human brain using PET with 18F-FE-PE2I (460 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 2012 Jul; 53(7): 1065-1073.
Impact Factor: 5.774
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Takano A, Gulyas B, Varrone A, Karlsson P, Sjoholm N, Larsson S, Jonsson C, Odh R, Sparks R, Al Tawil N, Hoffmann A, Zimmermann T, Thiele A, Halldin C
* Biodistribution and radiation dosimetry of the 18 kDa translocator protein (TSPO) radioligand [ 18F]FEDAA1106: A human whole-body PET study (419 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2011 Nov; 38(11): 2058-2065.
Impact Factor: 4.991
View Export to BibTeX Export to EndNote
Esmaeilzadeh M, Farde L, Karlsson P, Varrone A, Halldin C, Waters S, Tedroff J
* Extrastriatal dopamine D 2 receptor binding in Huntington's disease (462 views)
Hum Brain Mapp (ISSN: 1065-9471, 1097-0193electronic, 1065-9471linking), 2011 Oct; 32(10): 1626-1636.
Impact Factor: 5.88
View Export to BibTeX Export to EndNote
Ocak M, Helbok A, Rangger C, Peitl PK, Nock BA, Morelli G, Eek A, Sosabowskijk, Breeman WA, Reubi JC, Decristoforo C
* Comparison of biological stability and metabolism of CCK2 receptor targeting peptides, a collaborative project under COST BM0607 (692 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2011 Sep; 38(8): 1426-1435.
Impact Factor: 4.991
View Export to BibTeX Export to EndNote
Varnäs K, Nyberg S, Halldin C, Varrone A, Takano A, Karlsson P, Andersson J, McCarthy D, Smith M, Pierson ME, Söderström J, Farde L
* Quantitative analysis of [11C]AZ10419369 binding to 5-HT 1B receptors in human brain (412 views)
J Cereb Blood Flow Metab (ISSN: 0271-678x), 2011 Jan; 31(1): 113-123.
Impact Factor: 5.008
View Export to BibTeX Export to EndNote
Ciccarelli M, Sorriento D, Cipolletta E, Santulli G, Fusco A, Zhou R-H, Eckhart AD, Peppel K, Koch WJ, Trimarco B, Iaccarino G
* Impaired neoangiogenesis in β2-adrenoceptor gene-deficient mice: Restoration by intravascular human β2-adrenoceptor gene transfer and role of NFkB and CREB transcription factors (367 views)
Br J Pharmacol British Journal Of Pharmacology (ISSN: 0007-1188), 2011; 162(3): 712-721.
Impact Factor: 4.409
View Export to BibTeX Export to EndNote
Nag S, Lehmann L, Kettschau G, Thiele A, Varrone A, Gulyas B, Halldin C
* Synthesis and evaluation of [F-18]fluororasagiline, a novel PET radioligand for MAO-B (289 views)
Journal Of Labelled Compounds & Radiopharmaceuticals (ISSN: 0362-4803), 2011; 54: N/D-N/D.
Impact Factor: 1.429
View Export to BibTeX Export to EndNote
Varrone A, Halldin C
Molecular imaging of the dopamine transporter (527 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 2010 Sep 1; 51(9): 1331-1334.
Impact Factor: 7.022
View Export to BibTeX Export to EndNote
Finnema SJ, Varrone A, Hwang TJ, Gulyas B, Pierson ME, Halldin C, Farde L
* Fenfluramine-induced serotonin release decreases [11C]AZ10419369 binding to 5-HT1B-receptors in the primate brain (349 views)
Synapse (ISSN: 0887-4476), 2010 Jul; 64(7): 573-577.
Impact Factor: 2.925
View Export to BibTeX Export to EndNote
Varrone A, Sjoholm N, Eriksson L, Gulyas B, Halldin C, Farde L
* Advancement in PET quantification using 3D-OP-OSEM point spread function reconstruction with the HRRT (517 views) (PDF 258 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2009 Oct; 36(10): 1639-1650.
Impact Factor: 4.531
View Export to BibTeX Export to EndNote
Varrone A, Steiger C, Schou M, Takano A, Finnema SJ, Guilloteau D, Gulyas B, Halldin C
* In vitro autoradiography and in vivo evaluation in cynomolgus monkey of [18F]FE-PE2I, a new dopamine transporter PET radioligand (520 views)
Synapse (ISSN: 0887-4476), 2009 Oct; 63(10): 871-880.
Impact Factor: 2.557
View Export to BibTeX Export to EndNote
Takano A, Gulyas B, Varrone A, Maguire RP, Halldin C
* Saturated norepinephrine transporter occupancy by atomoxetine relevant to clinical doses: A rhesus monkey study with (S, S)-[18F]FMeNER-D (372 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2009 Sep; 36(8): 1308-1314.
Impact Factor: 4.531
View Export to BibTeX Export to EndNote
Vergote J, Chalon S, Emond P, Vercouillie J, Pappata S, Guilloteau D
* New SPECT and PET dementia tracers (358 views)
Med Nucl (ISSN: 0928-1258), 2009 Mar; 33(3): 137-141.
Impact Factor: 0.155
View Export to BibTeX Export to EndNote
Takano A, Varrone A, Gulyas B, Karlsson P, Tauscher J, Halldin C
* Mapping of the norepinephrine transporter in man using PET with (S, S)-[F-18]FMeNER-D-2 (292 views) (PDF 204 views)
Neuroimage (ISSN: 1053-8119, 1053-8119linking), 2008 Sep 15; 41: 474-482.
Impact Factor: 5.694
View Export to BibTeX Export to EndNote
Takano A, Halldin C, Varrone A, Karlsson P, Sjoholm N, Stubbs JB, Schou M, Airaksinen AJ, Tauscher J, Gulyas B
* Biodistribution and radiation dosimetry of the norepinephrine transporter radioligand (S, S)-[18F]FMeNER-D2: A human whole-body PET study (264 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2008 Mar; 35(3): 630-636.
Impact Factor: 4.532
View Export to BibTeX Export to EndNote
Takano A, Gulyas B, Varrone A, Karlsson P, Schou M, Airaksinen AJ, Vandenhende F, Tauscher J, Halldin C
* Imaging the norepinephrine transporter with positron emission tomography: Initial human studies with (S, S)-[18F]FMeNER-D2 (304 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2008 Jan; 35(1): 153-157.
Impact Factor: 4.532
View Export to BibTeX Export to EndNote
Del Gatto A, Zaccaro L, Grieco P, Novellino E, Zannetti A, Del Vecchio S, Iommelli F, Salvatore M, Pedone C, Saviano M
* Novel And Selective Alpha (v) Beta3 Receptor Peptide Antagonist: Design, Synthesis, And Biological Behavior (618 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2006 Jun 1; 49(11): 3416-3420.
Impact Factor: 5.115
View Export to BibTeX Export to EndNote
Hirst WD, Abrahamsen B, Blaney FE, Calver AR, Aloj L, Price GW, Medhurst AD
* Differences In The Central Nervous System Distribution And Pharmacology Of The Mouse 5-Hydroxytryptamine-6 Receptor Compared With Rat And Human Receptors Investigated By Radioligand Binding, Site-Directed Mutagenesis, And Molecular Modeling (272 views)
Molecular Pharmacology, 2003; 64: 1295-1308.
Impact Factor: 4.12
View Export to BibTeX Export to EndNote
19 Records (18 excluding Abstracts).
Total impact factor: 79.775 (78.346 excluding Abstracts).
Total 5 year impact factor: 81.742 (80.848 excluding Abstracts).
Total impact factor: 79.775 (78.346 excluding Abstracts).
Total 5 year impact factor: 81.742 (80.848 excluding Abstracts).
490 views. Last view on Thursday 19 January 2023, 19:54:35
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