Sex differences in the serotonin 1A receptor and serotonin transporter binding in the human brain measured by PET(490 views) Jovanovic H, Lundberg J, Karlsson P, Cerin A, Saijo T, Varrone A, Halldin C, Nordstrom AL
Neuroimage (ISSN: 1053-8119, 1053-8119linking), 2008 Feb 1; 39(3): 1408-1419.
Keywords: Carbon 11, N [2 [4 (2 Methoxyphenyl) 1 Piperazinyl]ethyl] N (2 Pyridyl)cyclohexanecarboxamide, Radioligand, Serotonin 1a Receptor, Serotonin Transporter, Serotonin Uptake Inhibitor, Adult, Anxiety, Article, Brain Size, Depression, Dorsal Raphe Nucleus, Female, Hippocampus, Human, Human Experiment, In Vivo Study, Neocortex, Normal Human, Nuclear Magnetic Resonance Imaging, Positron Emission Tomography, Priority Journal, Quantitative Analysis, Receptor Binding, Serotoninergic System, Sex Difference, Statistical Analysis, Suicide, Benzylamines, Biological Markers, Brain Chemistry, Cerebral Cortex, Image Processing, Computer-Assisted, Positron-Emission Tomography, Protein Binding, Pyridines, Radiopharmaceuticals, 5-Ht1a, Serotonin Antagonists, Serotonin Plasma Membrane Transport Proteins, Sex Characteristics, N [2 [4 (2 Methoxyphenyl) 1 Piperazinyl] Ethyl] N (2 Pyridyl) Cyclohexanecarboxamide,
Affiliations: *** IBB - CNR ***
Karolinska Institutet, Department of Clinical Neuroscience, Psychiatry Section, Stockholm, Sweden
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Cosgrove, K. P., Mazure, C. M., Staley, J. K., Evolving Knowledge of Sex Differences in Brain Structure, Function, and Chemistry (2007) Biol. Psychiatry, 62, pp. 847-855
David, S. P., Murthy, N. V., Rabiner, E. A., A functional genetic variation of the serotonin (5-HT) transporter affects 5-HT1A receptor binding in humans (2005) J. Neurosci., 25, pp. 2586-2590
Drevets, W. C., Frank, E., Price, J. C., Kupfer, D. J., Holt, D., Greer, P. J., Huang, Y., Mathis, C., PET imaging of serotonin 1A receptor binding in depression (1999) Biol. Psychiatry, 46, pp. 1375-1387
Epperson, C. N., Haga, K., Mason, G. F., Sellers, E., Gueorguieva, R., Zhang, W., Weiss, E., Krystal, J. H., Cortical gamma-aminobutyric acid levels across the menstrual cycle in healthy women and those with premenstrual dysphoric disorder: a proton magnetic resonance spectroscopy study (2002) Arch. Gen. Psychiatry, 59, pp. 851-858
Frankle, W. G., Huang, Y., Hwang, D. R., Talbot, P. S., Slifstein, M., Van Heertum, R., Abi-Dargham, A., Laruelle, M., Comparative evaluation of serotonin transporter radioligands 11C-DASB and 11C-McN 5652 in healthy humans (2004) J. Nucl. Med., 45, pp. 682-694
Friston, K. J., Holms, A. P., Worsley, K. J., Poline, J. B., Frith, C., Frackowiak, R. S. J., Statistical parametric maps in functional imaging: a general linear approach (1995) Hum. Brain Mapp., 2, pp. 189-210
Gorman, J. M., Gender differences in depression and response to psychotropic medication (2006) Gend. Med., 3, pp. 93-109
Gottfries, C. G., Roos, B. E., Winblad, B., Determination of 5-hydroxytryptamine, 5-hydroxyindoleacetic acid and homovanillic acid in brain tissue from an autopsy material (1974) Acta Psychiatr. Scand., 50, pp. 496-507
Gunn, R. N., Lammertsma, A. A., Hume, S. P., Cunningham, V. J., Parametric imaging of ligand-receptor binding in PET using a simplified reference region model (1997) NeuroImage, 6, pp. 279-287
Gunn, R. N., Sargent, P. A., Bench, C. J., Rabiner, E. A., Osman, S., Pike, V. W., Hume, S. P., Lammertsma, A. A., Tracer kinetic modeling of the 5-HT1A receptor ligand [carbonyl-11C] WAY-100635 for PET (1998) NeuroImage, 8, pp. 426-440
Kendler, K. S., Thornton, L. M., Gardner, C. O., Stressful life events and previous episodes in the etiology of major depression in women: an evaluation of the "kindling" hypothesis (2000) Am. J. Psychiatry, 157, pp. 1243-1251
Kessler, R. C., McGonagle, K. A., Swartz, M., Blazer, D. G., Nelson, C. B., Sex and depression in the National Comorbidity Survey. I: Lifetime prevalence, chronicity and recurrence (1993) J. Affect. Disord., 29, pp. 85-96
Krasikova, R. N., Truong, P., Halldin, C., A fully automated production of [carbolyl-11C] WAY-10035 for clinical PET studies (2003) J. Label. Compd. Radiopharm., 46, p. 244
Lesch, K. P., Bengel, D., Heils, A., Sabol, S. Z., Greenberg, B. D., Petri, S., Benjamin, J., Murphy, D. L., Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region (1996) Science, 274, pp. 1527-1531
Lewinsohn, P. M., Rohde, P., Seeley, J. R., Baldwin, C. L., Gender differences in suicide attempts from adolescence to young adulthood (2001) J. Am. Acad. Child Adolesc. Psych., 40, pp. 427-434
Madeira, M. D., Lieberman, A. R., Sexual dimorphism in the mammalian limbic system (1995) Prog. Neurobiol., 45, pp. 275-333
Moses, E. L., Drevets, W. C., Smith, G., Mathis, C. A., Kalro, B. N., Butters, M. A., Leondires, M. P., Berga, S. L., Effects of estradiol and progesterone administration on human serotonin 2A receptor binding: a PET study (2000) Biol. Psychiatry, 48, pp. 854-860
Parsey, R. V., Oquendo, M. A., Simpson, N. R., Ogden, R. T., Van Heertum, R., Arango, V., Mann, J. J., Effects of sex, age, and aggressive traits in man on brain serotonin 5-HT1A receptor binding potential measured by PET using [C-11] WAY-100635 (2002) Brain Res., 954, pp. 173-182
Parsey, R. V., Arango, V., Olvet, D. M., Oquendo, M. A., Van Heertum, R. L., Mann, J. J., Regional heterogeneity of 5-HT1A receptors in human cerebellum as assessed by positron emission tomography (2005) J. Cereb. Blood Flow Metab., 25, pp. 785-793
Parsey, R. V., Hastings, R. S., Oquendo, M. A., Huang, Y. Y., Simpson, N., Arcement, J., Huang, Y., Mann, J. J., Lower serotonin transporter binding potential in the human brain during major depressive episodes (2006) Am. J. Psychiatry, 163, pp. 52-58
Parsey, R. V., Olvet, D. M., Oquendo, M. A., Huang, Y. Y., Ogden, R. T., Mann, J. J., Higher 5-HT1A receptor binding potential during a major depressive episode predicts poor treatment response: preliminary data from a naturalistic study (2006) Neuropsychopharmacology, 31, pp. 1745-1749
Pigott, T. A., Gender differences in the epidemiology and treatment of anxiety disorders (1999) J. Clin. Psychiatry, 60 (SUPPL. 18), pp. 4-15
Pugliese, A. M., Passani, M. B., Corradetti, R., Effect of the selective 5-HT1A receptor antagonist WAY 100635 on the inhibition of e. p. s. ps produced by 5-HT in the CA1 region of rat hippocampal slices (1998) Br. J. Pharmacol., 124, pp. 93-100
Reiman, E. M., Armstrong, S. M., Matt, K. S., Mattox, J. H., The application of positron emission tomography to the study of the normal menstrual cycle (1996) Hum. Reprod., 11, pp. 2799-2805
Rosecrans, J. A., Differences in brain area 5-hydroxytryptamine turnover and rearing behavior in rats and mice of both sexes (1970) Eur. J. Pharmacol., 9, pp. 379-382
Rousset, O. G., Ma, Y., Evans, A. C., Correction for partial volume effects in PET: principle and validation (1998) J. Nucl. Med., 39, pp. 904-911
Sargent, P. A., Kjaer, K. H., Bench, C. J., Rabiner, E. A., Messa, C., Meyer, J., Gunn, R. N., Cowen, P. J., Brain serotonin1A receptor binding measured by positron emission tomography with [11C] WAY-100635: effects of depression and antidepressant treatment (2000) Arch. Gen. Psychiatry, 57, pp. 174-180
Staley, J. K., Krishnan-Sarin, S., Zoghbi, S., Tamagnan, G., Fujita, M., Seibyl, J. P., Maciejewski, P. K., Innis, R. B., Sex differences in [123I] beta-CIT SPECT measures of dopamine and serotonin transporter availability in healthy smokers and nonsmokers (2001) Synapse, 41, pp. 275-284
Staley, J. K., Sanacora, G., Tamagnan, G., Maciejewski, P. K., Malison, R. T., Berman, R. M., Vythilingam, M., Innis, R. B., Sex differences in diencephalon serotonin transporter availability in major depression (2006) Biol. Psychiatry, 59, pp. 40-47
Turner, M. R., Rabiner, E. A., Hammers, A., Al-Chalabi, A., Grasby, P. M., Shaw, C. E., Brooks, D. J., Leigh, P. N., [11C] -WAY100635 PET demonstrates marked 5-HT1A receptor changes in sporadic ALS (2005) Brain, 128, pp. 896-905
van Dyck, C. H., Malison, R. T., Staley, J. K., Jacobsen, L. K., Seibyl, J. P., Laruelle, M., Baldwin, R. M., Gelernter, J., Central serotonin transporter availability measured with [123I] beta-CIT SPECT in relation to serotonin transporter genotype (2004) Am. J. Psychiatry, 161, pp. 525-531
Weiss, L. A., Pan, L., Abney, M., Ober, C., The sex-specific genetic architecture of quantitative traits in humans (2006) Nat. Genet., 38, pp. 218-222
Young, S. N., Gauthier, S., Anderson, G. M., Purdy, W. C., Tryptophan, 5-hydroxyindoleacetic acid and indoleacetic acid in human cerebrospinal fluid: interrelationships and the influence of age, sex, epilepsy and anticonvulsant drugs (1980) J. Neurol., Neurosurg. Psychiatry, 43, pp. 438-445
Sex differences in the serotonin 1A receptor and serotonin transporter binding in the human brain measured by PET