Structural characterization of a neurotoxic threonine-rich peptide corresponding to the human prion protein α2-helical 180-195 segment and comparison with full-length α2-helix-derived peptides (411 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2008; 14(10): 1096-1102.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 1.654, 5-year impact factor: 1.782
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-57849162808&partnerID=40&md5=3565f0eefd50cdd0476d7d8ffba563b1
Keywords: α2-Helix, β-Sheet, Amyloid, Cd Titration, Encephalopathies, Nmr Structure, Prion Protein, Prion Toxicity, Transmissible Spongiform, Dodecyl Sulfate, Threonine, Alpha Helix, Article, Beta Sheet, Carboxy Terminal Sequence, Circular Dichroism, Nuclear Magnetic Resonance, Peptide Synthesis, Priority Journal, Protein Conformation, Protein Folding, Structure Activity Relation, Humans, Magnetic Resonance Spectroscopy, Neurotoxins, Protein Structure, Secondary, Tertiary, Trifluoroethanol, Water,
Affiliations:
*** IBB - CNR ***
Dipartimento delle Scienze Biologiche, C.I.R.Pe.B., Università Federico II di Napoli, Via Mezzocannone 16, 80134 Naples, Italy
Dipartimento de Scienze e Tecnologie per l'Ambiente e Il Territorio, Università del Molise, Pesche, Italy
Istituto di Chimica Biomolecolare, CNR, Pozzuoli, Italy
Dipartimento di Biochimica e Biofisica, CRISCEB, Seconda Università di Napoli, Naples, Italy
References:
Cohen, F.E., Prusiner, S.B., Pathologic conformations of prion proteins (1998) Annu. Rev. Biochem, 67, pp. 793-81
Riek, R., Hornemann, S., Wider, G., Billeter, M., Glockshuber, R., Wüthrich, K., NMR structure of the mouse prion protein domain PrP(121-321) (1996) Nature, 382, pp. 180-182
Zahn, R., Liu, A., Lührs, T., Riek, R., von Schroetter, C., Garcia, F.L., Billeter, M., Wüthrich, K., NMR solution structure of the human prion protein (2000) Proc. Natl. Acad. Sci. U.S.A, 97, pp. 145-150
López Garcia, F., Zahn, R., Riek, R., Wüthrich, K., NMR structure of the bovine prion protein (2000) Proc. Natl. Acad. Sci. U.S.A, 97, pp. 8334-8339
Pérez, D.R., Wüthrich, K., NMR assignment of the Xenopus laevis prion protein fragment xlPrP (98-226) (2005) J. Biomol. NMR, 31, pp. 260-260
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Gossert, A.D., Bonjour, S., Lysek, D.A., Fiorito, F., Wüthrich, K., Prion protein NMR structures of elk and of mouse/elk hybrids (2005) Proc. Natl. Acad. Sci. U.S.A, 102, pp. 646-650
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Ronga, L., Tizzano, B., Palladino, P., Ragone, R., Urso, E., Maffia, M., Ruvo, M., Rossi, F., The prion protein: Structural features and related toxic peptides (2006) Chem. Biol. Drug Des, 68, pp. 139-147
Ronga, L., Palladino, P., Costantini, S., Facchiano, A., Ruvo, M., Benedetti, E., Ragone, R., Rossi, F., Conformational diseases and structure-toxicity relationships: Lessons from prion-derived peptides (2007) Curr. Protein Pept. Sci, 8, pp. 83-90
Legname, G., Baskalov, I.V., Nguyen, H.-O.B., Riesner, D., Cohen, F.E., DeArmond, S.J., Prusiner, S.B., Synthetic mammalian prions (2004) Science, 305, pp. 673-676
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Kelly, J.W., The alternative conformations of amyloidogenic proteins and their multi-step assembly pathways (1998) Curr. Opin. Struct. Biol, 8, pp. 101-106
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Perrier, V., Wallace, A.C., Kaneko, K., Safar, J., Prusiner, S.B., Cohen, F.E., Mimicking dominant negative inhibition of prion replication through structure-based drug design (2000) Proc. Natl. Acad. Sci. U.S.A, 97, pp. 6073-6078
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DuBay, K.F., Pawar, A.P., Chiti, F., Zurdo, J., Dobson, C.M., Vendruscolo, M., Prediction of the absolute aggregation rates of amyloidogenic polypeptide chains (2004) J. Mol. Biol, 341, pp. 1317-1326
Galzitskaya, O.V., Garbuzynskiy, S.O., Lobanov, M.Y., Prediction of amyloidogenic and disordered regions in protein chains (2006) PLoS Comput. Biol, 2, pp. 1639-1648
Dima, R.I., Thirumalai, D., Exploring the propensities of helices in PrPC to form β sheet using NMR structures and sequence alignments (2002) Biophys. J, 83, pp. 1268-1280
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Cohen, F. E., Prusiner, S. B., Pathologic conformations of prion proteins (1998) Annu. Rev. Biochem, 67, pp. 793-81
L pez Garcia, F., Zahn, R., Riek, R., W thrich, K., NMR structure of the bovine prion protein (2000) Proc. Natl. Acad. Sci. U. S. A, 97, pp. 8334-8339
P rez, D. R., W thrich, K., NMR assignment of the Xenopus laevis prion protein fragment xlPrP (98-226) (2005) J. Biomol. NMR, 31, pp. 260-260
Lysek, D. A., Schorn, C., Nivon, L. G., Esteve-Moya, V., Christen, B., Calzolai, L., von Schroetter, C., W thrich, K., Prion protein NMR structures of cats, dogs, pigs, and sheep (2005) Proc. Natl. Acad. Sci. U. S. A, 102, pp. 640-645
Gossert, A. D., Bonjour, S., Lysek, D. A., Fiorito, F., W thrich, K., Prion protein NMR structures of elk and of mouse/elk hybrids (2005) Proc. Natl. Acad. Sci. U. S. A, 102, pp. 646-650
Prusiner, S. B., Prions (1998) Proc. Natl. Acad. Sci. U. S. A, 95, pp. 13363-13383
Kelly, J. W., The alternative conformations of amyloidogenic proteins and their multi-step assembly pathways (1998) Curr. Opin. Struct. Biol, 8, pp. 101-106
Scott, M. R., Will, R., Ironside, J., Nguyen, H. -O. B., Tremblay, P., DeArmond, S. J., Prusiner, S. B., Compelling transgenetic evidence for transmission of bovine spongiform encephalopathy prions to humans (1999) Proc. Natl. Acad. Sci. U. S. A, 96, pp. 15137-15142
Jackson, G. S., Hosszu, L. L., Power, A., Hill, A. F., Kenney, J., Saibil, H., Craven, C. J., Collinge, J., Reversible conversion of monomeric human prion protein between native and fibrillogenic conformations (1999) Science, 283, pp. 1935-1937
Bosques, C. J., Imperiali, B., The interplay of glycosylation and disulfide formation influences fibrillization in a prion protein fragment (2003) Proc. Natl. Acad. Sci. U. S. A, 100, pp. 7593-7598
Brown, D. R., Guantieri, V., Grasso, G., Impellizzeri, G., Pappalardo, G., Rizzarelli, E., Copper (II) complexes of peptide fragments of the prion protein. Conformation changes induced by copper (II) and the binding motif in C-terminal protein region (2004) J. Inorg. Biochem, 98, pp. 133-143
DuBay, K. F., Pawar, A. P., Chiti, F., Zurdo, J., Dobson, C. M., Vendruscolo, M., Prediction of the absolute aggregation rates of amyloidogenic polypeptide chains (2004) J. Mol. Biol, 341, pp. 1317-1326
Galzitskaya, O. V., Garbuzynskiy, S. O., Lobanov, M. Y., Prediction of amyloidogenic and disordered regions in protein chains (2006) PLoS Comput. Biol, 2, pp. 1639-1648
Dima, R. I., Thirumalai, D., Exploring the propensities of helices in PrPC to form sheet using NMR structures and sequence alignments (2002) Biophys. J, 83, pp. 1268-1280
Prusiner, S. B., Molecular biology and pathogenesis of prion diseases (1996) Trends Biochem. Sci, 21, pp. 482-487
Shamsir, M. S., Dalby, A. R., One gene, two diseases and three conformations: Molecular dynamics simulations of mutants human prion protein at room temperature and elevated temperatures (2005) Proteins, 59, pp. 275-290
Cobb, N. J., S nnichsen, F. D., McHaourab, H., Surewicz, W. K., Molecular architecture of human prion protein amyloid: A parallel, in-register beta-structure (2007) Proc. Natl. Acad. Sci. U. S. A, 104, pp. 18946-18951
Wu, C. S., Ikeda, K., Yang, J. T., Ordered conformation of polypeptides and proteins in acidic dodecyl sulfate solution (1981) Biochemistry, 20, pp. 566-570
Wu, C. S., Yang, J. T., Sequence-dependent conformations of short polypeptides in a hydrophobic environment (1981) Mol. Cell. Biochem, 40, pp. 109-122
W thrich, K., (1986) NMR of Proteins and Nucleic Acids, , Wiley: New York
G ntert, P., Braun, W., W thrich, K., Efficient computation of three-dimensional protein structures in solution from nuclear magnetic resonance data using the program DIANA and the supporting programs CALIBA, HABAS and GLOMSA (1991) J. Mol. Biol, 217, pp. 517-530
G ntert, P., Mumenthaler, C., W thrich, K., Torsion angle dynamics for NMR structure calculation with the new program DYANA (1997) J. Mol. Biol, 273, pp. 283-298
Bordbar, A. K., Saboury, A. A., Housaindokht, M. R., Moosavi-Movahedi, A. A., Statistical effects of the binding of ionic surfactant to protein (1997) J. Colloid Interface Sci, 192, pp. 415-419
Cox, D. L., Pan, J., Singh, R. R. P., A mechanism for copper inhibition of infectious prion conversion (2006) Biophys. J, 91, pp. L11-L13
Haire, L. F., Whyte, S. M., Vasisht, N., Gill, A. C., Verma, C., Dodson, E. J., Dodson, G. G., Bayley, P. M., The crystal structure of the globular domain of sheep prion protein (2004) J. Mol. Biol, 336, pp. 1175-1183
Knaus, K. J., Morillas, M., Swletnicki, W., Malone, M., Surewicz, W. K., Yee, V. C., Crystal structure of the human prion protein reveals a mechanism for oligomerization (2001) Nat. Struct. Biol, 8, pp. 770-774
Jackson, G. S., Collinge, J., The molecular pathology of CJD: Old and new variants (2001) Mol. Pathol, 54, pp. 393-399
Fitzmaurice, T. J., Burke, D. F., Hopkins, L., Yang, S., Yu, S., Sy, M. -S., Thackray, A. M., Bujdoso, R., The stability and aggregation of ovine prion protein associated with classical and atypical scruple correlates with the case of unwinding of helix-2 (2008) Biochem J, 409, pp. 367-375
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2008; 14(10): 1096-1102.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 1.654, 5-year impact factor: 1.782
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-57849162808&partnerID=40&md5=3565f0eefd50cdd0476d7d8ffba563b1
Keywords: α2-Helix, β-Sheet, Amyloid, Cd Titration, Encephalopathies, Nmr Structure, Prion Protein, Prion Toxicity, Transmissible Spongiform, Dodecyl Sulfate, Threonine, Alpha Helix, Article, Beta Sheet, Carboxy Terminal Sequence, Circular Dichroism, Nuclear Magnetic Resonance, Peptide Synthesis, Priority Journal, Protein Conformation, Protein Folding, Structure Activity Relation, Humans, Magnetic Resonance Spectroscopy, Neurotoxins, Protein Structure, Secondary, Tertiary, Trifluoroethanol, Water,
Affiliations:
*** IBB - CNR ***
Dipartimento delle Scienze Biologiche, C.I.R.Pe.B., Università Federico II di Napoli, Via Mezzocannone 16, 80134 Naples, Italy
Dipartimento de Scienze e Tecnologie per l'Ambiente e Il Territorio, Università del Molise, Pesche, Italy
Istituto di Chimica Biomolecolare, CNR, Pozzuoli, Italy
Dipartimento di Biochimica e Biofisica, CRISCEB, Seconda Università di Napoli, Naples, Italy
References:
Cohen, F.E., Prusiner, S.B., Pathologic conformations of prion proteins (1998) Annu. Rev. Biochem, 67, pp. 793-81
Riek, R., Hornemann, S., Wider, G., Billeter, M., Glockshuber, R., Wüthrich, K., NMR structure of the mouse prion protein domain PrP(121-321) (1996) Nature, 382, pp. 180-182
Zahn, R., Liu, A., Lührs, T., Riek, R., von Schroetter, C., Garcia, F.L., Billeter, M., Wüthrich, K., NMR solution structure of the human prion protein (2000) Proc. Natl. Acad. Sci. U.S.A, 97, pp. 145-150
López Garcia, F., Zahn, R., Riek, R., Wüthrich, K., NMR structure of the bovine prion protein (2000) Proc. Natl. Acad. Sci. U.S.A, 97, pp. 8334-8339
Pérez, D.R., Wüthrich, K., NMR assignment of the Xenopus laevis prion protein fragment xlPrP (98-226) (2005) J. Biomol. NMR, 31, pp. 260-260
Lysek, D.A., Schorn, C., Nivon, L.G., Esteve-Moya, V., Christen, B., Calzolai, L., von Schroetter, C., Wüthrich, K., Prion protein NMR structures of cats, dogs, pigs, and sheep (2005) Proc. Natl. Acad. Sci. U.S.A, 102, pp. 640-645
Gossert, A.D., Bonjour, S., Lysek, D.A., Fiorito, F., Wüthrich, K., Prion protein NMR structures of elk and of mouse/elk hybrids (2005) Proc. Natl. Acad. Sci. U.S.A, 102, pp. 646-650
Calzolai, L., Lysek, D.A., Pérez, D.R., Güntert, P., Wüthrich, K., Prion protein NMR structures of chickens, turtles, and frogs (2005) Proc. Natl. Acad. Sci. U.S.A, 102, pp. 651-655
Ronga, L., Tizzano, B., Palladino, P., Ragone, R., Urso, E., Maffia, M., Ruvo, M., Rossi, F., The prion protein: Structural features and related toxic peptides (2006) Chem. Biol. Drug Des, 68, pp. 139-147
Ronga, L., Palladino, P., Costantini, S., Facchiano, A., Ruvo, M., Benedetti, E., Ragone, R., Rossi, F., Conformational diseases and structure-toxicity relationships: Lessons from prion-derived peptides (2007) Curr. Protein Pept. Sci, 8, pp. 83-90
Legname, G., Baskalov, I.V., Nguyen, H.-O.B., Riesner, D., Cohen, F.E., DeArmond, S.J., Prusiner, S.B., Synthetic mammalian prions (2004) Science, 305, pp. 673-676
Prusiner, S.B., Prions (1998) Proc. Natl. Acad. Sci. U.S.A, 95, pp. 13363-13383
Kelly, J.W., The alternative conformations of amyloidogenic proteins and their multi-step assembly pathways (1998) Curr. Opin. Struct. Biol, 8, pp. 101-106
Scott, M.R., Will, R., Ironside, J., Nguyen, H.-O.B., Tremblay, P., DeArmond, S.J., Prusiner, S.B., Compelling transgenetic evidence for transmission of bovine spongiform encephalopathy prions to humans (1999) Proc. Natl. Acad. Sci. U.S.A, 96, pp. 15137-15142
Kaneko, K., Zulianello, L., Scott, M., Cooper, C.M., Wallace, A.C., James, T.L., Cohen, F.E., Prusiner, S.B., Evidence for protein X binding to a discontinuous epitope on the cellular prion protein during scrapie prion propagation (1997) Proc. Natl. Acad. Sci. U.S.A, 94, pp. 10069-10074
Perrier, V., Wallace, A.C., Kaneko, K., Safar, J., Prusiner, S.B., Cohen, F.E., Mimicking dominant negative inhibition of prion replication through structure-based drug design (2000) Proc. Natl. Acad. Sci. U.S.A, 97, pp. 6073-6078
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Wu, C. S., Ikeda, K., Yang, J. T., Ordered conformation of polypeptides and proteins in acidic dodecyl sulfate solution (1981) Biochemistry, 20, pp. 566-570
Wu, C. S., Yang, J. T., Sequence-dependent conformations of short polypeptides in a hydrophobic environment (1981) Mol. Cell. Biochem, 40, pp. 109-122
W thrich, K., (1986) NMR of Proteins and Nucleic Acids, , Wiley: New York
G ntert, P., Braun, W., W thrich, K., Efficient computation of three-dimensional protein structures in solution from nuclear magnetic resonance data using the program DIANA and the supporting programs CALIBA, HABAS and GLOMSA (1991) J. Mol. Biol, 217, pp. 517-530
G ntert, P., Mumenthaler, C., W thrich, K., Torsion angle dynamics for NMR structure calculation with the new program DYANA (1997) J. Mol. Biol, 273, pp. 283-298
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Cox, D. L., Pan, J., Singh, R. R. P., A mechanism for copper inhibition of infectious prion conversion (2006) Biophys. J, 91, pp. L11-L13
Haire, L. F., Whyte, S. M., Vasisht, N., Gill, A. C., Verma, C., Dodson, E. J., Dodson, G. G., Bayley, P. M., The crystal structure of the globular domain of sheep prion protein (2004) J. Mol. Biol, 336, pp. 1175-1183
Knaus, K. J., Morillas, M., Swletnicki, W., Malone, M., Surewicz, W. K., Yee, V. C., Crystal structure of the human prion protein reveals a mechanism for oligomerization (2001) Nat. Struct. Biol, 8, pp. 770-774
Jackson, G. S., Collinge, J., The molecular pathology of CJD: Old and new variants (2001) Mol. Pathol, 54, pp. 393-399
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Structural characterization of a neurotoxic threonine-rich peptide corresponding to the human prion protein α2-helical 180-195 segment and comparison with full-length α2-helix-derived peptides
The 173-195 segment corresponding to the helix 2 of the globular PrP domain is a good candidate to be one of the several 'spots' of intrinsic structural flexibility, which might induce local destabilization and concur to protein transformation, leading to aggregation-prone conformations. Here, we report CD and NMR studies on the α2-helix-derived peptide of maximal length (hPrP[180-195]) that is able to exhibit a regular structure different from the prevalently random arrangement of other α2-helix-derived peptides. This peptide, which has previously been shown to be affected by buffer composition via the ion charge density dependence typical of Hofmeister effects, corresponds to the C-terminal sequence of the PrPC full-length α2-helix and includes the highly conserved threonine-rich 188-195 segment. At neutral pH, its conformation is dominated by β-type contributions, which only very strong environmental modifications are able to modify. On TFE addition, an increase of α-helical content can be observed, but a fully helical conformation is only obtained in neat TFE. However, linking of the 173-179 segment, as occurring in wild-type and mutant peptides corresponding to the full-length α2-helix, perturbs these intrinsic structural propensities in a manner that depends on whether the environment is water or TFE. Overall, these results confirm that the 180-195 parental region in hPrPC makes a strong contribution to the chameleon conformational behavior of the segment corresponding to the full-length α2-helix, and could play a role in determining structural rearrangements of the entire globular domain. Copyright © 2008 European Peptide Society and John Wiley & Sons, Ltd.
The 173-195 segment corresponding to the helix 2 of the globular PrP domain is a good candidate to be one of the several 'spots' of intrinsic structural flexibility, which might induce local destabilization and concur to protein transformation, leading to aggregation-prone conformations. Here, we report CD and NMR studies on the α2-helix-derived peptide of maximal length (hPrP[180-195]) that is able to exhibit a regular structure different from the prevalently random arrangement of other α2-helix-derived peptides. This peptide, which has previously been shown to be affected by buffer composition via the ion charge density dependence typical of Hofmeister effects, corresponds to the C-terminal sequence of the PrPC full-length α2-helix and includes the highly conserved threonine-rich 188-195 segment. At neutral pH, its conformation is dominated by β-type contributions, which only very strong environmental modifications are able to modify. On TFE addition, an increase of α-helical content can be observed, but a fully helical conformation is only obtained in neat TFE. However, linking of the 173-179 segment, as occurring in wild-type and mutant peptides corresponding to the full-length α2-helix, perturbs these intrinsic structural propensities in a manner that depends on whether the environment is water or TFE. Overall, these results confirm that the 180-195 parental region in hPrPC makes a strong contribution to the chameleon conformational behavior of the segment corresponding to the full-length α2-helix, and could play a role in determining structural rearrangements of the entire globular domain. Copyright © 2008 European Peptide Society and John Wiley & Sons, Ltd.
Structural characterization of a neurotoxic threonine-rich peptide corresponding to the human prion protein α2-helical 180-195 segment and comparison with full-length α2-helix-derived peptides
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Structural characterization of a neurotoxic threonine-rich peptide corresponding to the human prion protein α2-helical 180-195 segment and comparison with full-length α2-helix-derived peptides
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Di Natale G, Pappalardo G, Milardi D, Sciacca MFM, Attanasio F, La Mendola D, Rizzarelli E
* Different Interactions Of Human And Avian Prion Proteins N-Terminal Tandem Repeat Peptides And Their Copper (ii) Complexes With Model Membranes (385 views)
Journal Of Chemical Physics, 2010; 114: 13830-13838.
Impact Factor: 2.028
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Palladino P, Ronga L, Benedetti E, Rossi F, Ragone R
* Peptide Fragment Approach to Prion Misfolding: The Alpha-2 Domain (401 views)
Int J Pept Res Ther (ISSN: 1573-3149, 0929-5666), 2009 Sep; 15(3): 165-176.
Impact Factor: 0.869
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Pietropaolo A, Muccioli L, Zannoni C, Rizzarelli E
* Conformational preferences of the full chicken prion protein in solution and its differences with respect to mammals (382 views)
Chemphyschem (ISSN: 1439-7641, 1439-4235, 1439-7641electronic), 2009 Jul 13; 10(9-10): 1500-1510.
Impact Factor: 3.453
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La Mendola D, Pietropaolo A, Pappalardo G, Zannoni C, Rizzarelli E
* Prion Proteins Leading to Neurodegeneration (vol 5, pg 579, 2008) (233 views)
Current Alzheimer Research (ISSN: 1567-2050), 2009 Jun; 6(3): N/D-N/D.
Impact Factor: 4.971
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Di Natale G, Osz K, Nagy Z, Sanna D, Micera G, Pappalardo G, Sovago I, Rizzarelli E
* The Interaction Of Copper (ii) With The Prion Peptide Fragment Huprp (76-114) Encompassing Four Histidyl Residues Within And Outside The Octarepeat Domain (323 views)
Inorg Chem (ISSN: 0020-1669, 1520-510x, 1520-510xelectronic), 2009 May 4; 48(9): 4239-4250.
Impact Factor: 4.657
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La Mendola D, Magrì A, Hansson O, Bonomo RP, Rizzarelli E
* Copper(II) complexes with peptide fragments encompassing the sequence 122-130 of human doppel protein (361 views)
Journal Of Inorganic Biochemistry, 2009 May; 103(5): 758-765.
Impact Factor: 3.444
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Bonomo RP, Di Natale G, Rizzarelli E, Tabbì G, Vagliasindi LI
* Copper(II) complexes of prion protein PEG11-tetraoctarepeat fragment: spectroscopic and voltammetric studies (411 views)
Dalton T (ISSN: 1477-9226, 1477-7922, 1477-9234), 2009 Apr 14; (14): 2637-2646.
Impact Factor: 2.908
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Ronga L, Palladino P, Ragone R, Benedetti E, Rossi F
* A thermodynamic approach to the conformational preferences of the 180-195 segment derived from the human prion protein α2-helix (286 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009; 15(1): 30-35.
Impact Factor: 1.807
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La Mendola D, Pietropaolo A, Pappalardo G, Zannoni C, Rizzarelli E
* Prion proteins leading to neurodegeneration (420 views)
Current Alzheimer Research (ISSN: 1567-2050), 2008 Dec; 5(6): 579-590.
Impact Factor: 4.132
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Bonomo RP, Pappalardo G, Rizzarelli E, Tabbì G, Vagliasindi LI
* Studies of nitric oxide interaction with mono- and dinuclear copper(II) complexes of prion protein bis-octarepeat fragments (309 views)
Dalton T (ISSN: 1477-9226, 1477-9234, 1477-9234electronic), 2008 Sep 7; (29): 3805-3816.
Impact Factor: 3.58
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Pietropaolo A, Muccioli L, Zannoni C, La Mendola D, Maccarrone G, Pappalardo G, Rizzarelli E
* Unveiling the role of histidine and tyrosine residues on the conformation of the avian prion hexarepeat domain (343 views)
J Phys Chem B (ISSN: 1520-6106, 1520-5207, 1520-5207electronic), 2008 Apr 24; 112(16): 5182-5188.
Impact Factor: 4.189
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Colangelo AM, Bianco MR, Vitagliano L, Cavaliere C, Cirillo G, De Gioia L, Diana D, Colombo D, Redaelli C, Zaccaro L, Morelli G, Papa M, Sarmientos P, Alberghina L, Martegani E
* A New Nerve Growth Factor (ngf)-Mimetic Peptide Active On Neuropathic Pain In Rats (657 views)
J Neurosci (ISSN: 0270-6474, 0270-0647, 1529-2401), 2008 Mar 12; 28(11): 2698-2709.
Impact Factor: 7.452
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De Simone A, Pedone C, Vitagliano L
* Structure, dynamics, and stability of assemblies of the human prion fragment SNQNNF (503 views)
Biochem Biophys Res Commun (ISSN: 1090-2104, 0006-291x, 1090-2104electronic), 2008 Feb 15; 366(3): 800-806.
Impact Factor: 2.648
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Bonomo RP, Pappalardo G, Rizzarelli E, Santoro AM, Tabbì G, Vagliasindi LI
* Nitrogen oxide interaction with copper complexes formed by small peptides belonging to the prion protein octa-repeat region (562 views)
Dalton T (ISSN: 1477-9226, 1477-9234, 1477-9234electronic), 2007 Apr 14; (14): 1400-1408.
Impact Factor: 3.212
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Ronga L, Langella E, Palladino P, Marasco D, Tizzano B, Saviano M, Pedone C, Improta R, Ruvo M
* Does Tetracycline Bind Helix 2 Of Prion? An Integrated Spectroscopical And Computational Study Of The Interaction Between The Antibiotic And Alpha Helix 2 Human Prion Protein Fragments (512 views)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2007 Feb 15; 66(3): 707-715.
Impact Factor: 3.354
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Ronga L, Palladino P, Costantini S, Facchiano A, Ruvo M, Benedetti E, Ragone R, Rossi F
* Conformational diseases and structure-toxicity relationships: Lessons from prion-derived peptides (553 views)
Curr Protein Pept Sci (ISSN: 1389-2037, 1389-2037linking), 2007 Feb; 8(1): 83-90.
Impact Factor: 3.259
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Rao M, Russo F, Granata V, Berisio R, Zagari A, Gianfreda L
* Fate of prions in soil: Interaction of a recombinant ovine prion protein with synthetic humic-like mineral complexes (426 views)
Soil Biol Biochem (ISSN: 0038-0717), 2007 Feb; 39(2): 493-504.
Impact Factor: 2.58
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Osz K, Nagy Z, Pappalardo G, Di Natale G, Sanna D, Micera G, Rizzarelli E, Sóvágó I
* Copper(II) interaction with prion peptide fragments encompassing histidine residues within and outside the octarepeat domain: speciation, stability constants and binding details (549 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2007; 13(25): 7129-7143.
Impact Factor: 5.33
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Ronga L, Palladino P, Saviano G, Tancredi T, Benedetti E, Ragone R, Rossi F
* NMR structure and CD titration with metal cations of human prion α2-helix-related peptides (465 views)
Bioinorg Chem Appl (ISSN: 1565-3633), 2007; 2007: N/D-N/D.
Impact Factor: 0.978
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Pappalardo M, Milardi D, Grasso D, La Rosa C
* Steered molecular dynamics studies reveal different unfolding pathways of prions from mammalian and non-mammalian species (338 views)
New J Chem (ISSN: 1144-0546), 2007; 31(6): 901-905.
Impact Factor: 2.651
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Ronga L, Palladino P, Tizzano B, Marasco D, Benedetti E, Ragone R, Rossi F
* Effect of salts on the structural behavior of hPrP α2-helix-derived analogues: The counterion perspective (454 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2006 Dec; 12(12): 790-795.
Impact Factor: 1.801
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Esposito L, Pedone C, Vitagliano L
* Molecular dynamics analyses of cross-beta-spine steric zipper models: beta-sheet twisting and aggregation (727 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2006 Sep 1; 103(31): 11533-11538.
Impact Factor: 9.643
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De Luca S, Saviano M, Della Moglie R, Digilio G, Bracco C, Aloj L, Tarallo L, Pedone C, Morelli G
* Conformationally constrained CCK8 analogues obtained from a rationally designed peptide library as ligands for cholecystokinin type B receptor (421 views)
Chemmedchem (ISSN: 1860-7179, 1860-7187, 1860-7187electronic), 2006 Sep; 1(9): 997-1006.
Impact Factor: 3.046
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Ronga L, Tizzano B, Palladino P, Ragone R, Urso E, Maffia M, Ruvo M, Benedetti E, Rossi F
* The prion protein: structural features and related toxic peptides (529 views)
Chem Biol Drug Des (ISSN: 1747-0277, 1747-0285), 2006 Sep; 68(3): 139-147.
Impact Factor: 2.507
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Joszal V, Nagy Z, Osz K, Sanna D, Di Natale G, La Mendola D, Pappalardo G, Rizzarelli E, Sovago I
* Transition metal complexes of terminally protected peptides containing histidyl residues (513 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2006 Sep; 100(8): 1399-1409.
Impact Factor: 2.654
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Langella E, Improta R, Crescenzi O, Barone V
* Assessing the acid-base and conformational properties of histidine residues in human prion protein (125-228) by means of pKα calculations and molecular dynamics simulations (581 views)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2006 Jul 1; 64(1): 167-177.
Impact Factor: 3.73
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Granata V, Palladino P, Tizzano B, Negro A, Berisio R, Zagari A
* The effect of the osmolyte trimethylamine N-oxide on the stability of the prion protein at low pH (402 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2006 Jun 15; 82(3): 234-240.
Impact Factor: 2.48
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Palladino P, Ronga L, Tizzano B, Rossi F, Ragone R, Tancredi T, Saviano G, Facchiano A, Costantini S, Ruvo M, Benedetti E
* Prion protein misfolding: Conformational stability of the alpha 2-helix (289 views)
Understanding Biology Using Peptides, 2006; N/D: N/D-N/D.
Impact Factor: 2.614
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Grasso D, Grasso G, Guantieri V, Impellizzeri G, La Rosa C, Milardi D, Micera G, Osz K, Pappalardo G, Rizzarelli E, Sanna D, Sovago I
* Environmental effects on a prion's helix II domain: copper(II) and membrane interactions with PrP180-193 and its analogues (432 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2005 Dec 23; 12(2): 537-547.
Impact Factor: 4.907
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La Mendola D, Bonomo RP, Impellizzeri G, Maccarrone G, Pappalardo G, Pietropaolo A, Rizzarelli E, Zito V
* Copper(II) complexes with chicken prion repeats: Influence of proline and tyrosine residues on the coordination features (303 views)
J Biol Inorg Chem (ISSN: 0949-8257, 1432-1327electronic, 0949-8257print), 2005 Sep; 10(5): 463-475.
Impact Factor: 3.224
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Tizzano B, Palladino P, De Capua A, Marasco D, Rossi F, Benedetti E, Pedone C, Ragone R, Ruvo M
* The Human Prion Protein Alpha2 Helix: A Thermodynamic Study Of Its Conformational Preferences (504 views)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2005 Apr 1; 59(1): 72-79.
Impact Factor: 4.684
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Di Natale G, Impellizzeri G, Pappalardo G
* Conformational properties of peptide fragments homologous to the 106-114 and 106-126 residues of the human prion protein: a CD and NMR spectroscopic study (424 views)
Org Biomol Chem (ISSN: 1477-0520, 1477-0539, 1477-0539electronic), 2005 Feb 7; 3(3): 490-497.
Impact Factor: 2.547
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Bonomo RP, Cucinotta V, Giuffrida A, Impellizzeri G, Magrì A, Pappalardo G, Rizzarelli E, Santoro AM, Tabbì G, Vagliasindi LI
* A re-investigation of copper coordination in the octa-repeats region of the prion protein (376 views)
Dalton T (ISSN: 1477-9226, 1477-9234, 1477-9234electronic), 2005 Jan 7; (1): 150-158.
Impact Factor: 3.003
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Langella E, Improta R, Barone V
* Checking the pH-induced conformational transition of prion protein by molecular dynamics simulations: Effect of protonation of histidine residues (427 views)
Biophysical Journal (ISSN: 0006-3495, 1542-0086), 2004 Dec; 87(6): 3623-3632.
Impact Factor: 4.585
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Pappalardo M, Milardi D, La Rosa C, Zannoni C, Rizzarelli E, Grasso D
* A molecular dynamics study on the conformational stability of PrP 180-193 helix II prion fragment (306 views)
Chem Phys Lett (ISSN: 0009-2614), 2004 Jun 1; 390(4-6): 511-516.
Impact Factor: 2.438
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Grasso D, Milardi D, La Rosa C, Rizzarelli E
* The different role of Cu++ and Zn++ ions in affecting the interaction of prion peptide PrP106-126 with model membranes (283 views)
Chem Commun (ISSN: 1359-7345, 1364-548x, 1364-548xelectronic), 2004 Jan 21; 10(2): 246-247.
Impact Factor: 3.997
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Brown DR, Guantieri V, Grasso G, Impellizzeri G, Pappalardo G, Rizzarelli E
* Copper(II) complexes of peptide fragments of the prion protein. Conformation changes induced by copper(II) and the binding motif in C-terminal protein region (495 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2004 Jan; 98(1): 133-143.
Impact Factor: 2.225
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Barone V, Improta R, Rega N
* Computation of protein pK's values by an integrated density functional theory/Polarizable Continuum Model approach (288 views)
Theor Chem Acc (ISSN: 1432-881x), 2004; 111(2-6): 237-245.
Impact Factor: 2.209
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Tizzano B, Marasco D, Benedetti E, De Capua A, Palladino P, Pedone C, Perretta G, Rossi F, Ragone R, Ruvo M
* Conformational conversion of prion proteins: Role synthetic PRP 173-195 fibrillogenic peptide (354 views)
Peptide Revolution, 2004; N/D: N/D-N/D.
Impact Factor: 4.659
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Pappalardo G, Impellizzeri G, Campagna T
* Copper(II) binding of prion protein's octarepeat model peptides (505 views)
Inorg Chim Acta (ISSN: 0020-1693), 2004; 357(1): 185-194.
Impact Factor: 1.554
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De Luca S, Ragone R, Bracco C, Digilio G, Aloj L, Tesauro D, Saviano M, Pedone C, Morelli G
* A cyclic CCK8 analogue selective for the cholecystokinin type A receptor: design, synthesis, NMR structure and binding measurements (472 views)
Chembiochem (ISSN: 1439-7633, 1439-4227, 1439-7633electronic), 2003 Nov 7; 4(11): 1176-1187.
Impact Factor: 3.992
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La Mendola D, Bonomo R, Maccarrone G, Pappalardo G, Rizzarelli E
* A thermodynamic and spectroscopic study on the copper(II) complexes with hexarepeats fragments of the avian prion protein (324 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2003 Jul 15; 96(1): N/D-N/D.
Impact Factor: 2.343
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Isernia C, Bucci E, Leone M, Zaccaro L, Di Lello P, Digilio G, Esposito S, Saviano M, Di Blasio B, Pedone C, Pedone PV, Fattorusso R
* NMR structure of the single QALGGH zinc finger domain from the Arabidopsis thaliana SUPERMAN protein (429 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2003 Mar 3; 4(2-3): 171-180.
Impact Factor: 3.992
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Bonomo RP, Grasso D, Grasso G, Guantieri V, Impellizzeri G, La Rosa C, Milardi D, Pappalardo G, Tabbì G, Rizzarelli E
* Metal binding to prion protein (269 views)
Metal-Ligand Interactions - Molecular Nano- Micro- And Macro-Systems In Complex Environments, 2003 Jan 01; 116: 21-39.
Impact Factor: 5.664
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Grasso D, Milardi D, Guantieri V, La Rosa C, Rizzarelli E
* Interaction of prion peptide PrP 180-193 with DPPC model membranes: A thermodynamic study (383 views)
New J Chem (ISSN: 1144-0546), 2003; 27(2): 359-364.
Impact Factor: 2.272
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Menziani MC, De Benedetti PG, Langella E, Barone V
* Seeking for binding determinants of the prion protein to human plasminogen (391 views)
Mol Phys (ISSN: 0026-8976), 2003; 101(17): 2763-2773.
Impact Factor: 1.591
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Grasso D, Milardi D, La Rosa C, Rizzarelli E
* DSC study of the interaction of the prion peptide PrP106-126 with artificial membranes (377 views)
New J Chem (ISSN: 1144-0546), 2001; 25(12): 1543-1548.
Impact Factor: 2.44
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Bonomo RP, Imperllizzeri G, Pappalardo G, Rizzarelli E, Tabbì G
Copper(II) binding modes in the prion octapeptide PHGGGWGQ: A spectroscopic and voltammetric study (502 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2000 Nov 17; 6(22): 4195-4202.
Impact Factor: 4.698
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* Unravelling the Structure of the Tetrahedral Metal-Binding Site in METP3 through an Experimental and Computational Approach (7 views)
Molecules (ISSN: 1420-3049linking, 1420-3049electronic), 2021 Aug 28; 26(17): N/D-N/D.
Impact Factor: 4.411
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Di Natale C, La Manna S, Avitabile C, Florio D, Morelli G, Netti PA, Marasco D
* Corrigendum to "Engineered β-hairpin scaffolds from human prion protein regions: Structural and functional investigations of aggregates" [Bioorg. Chem. 96 (2020) 103594] (36 views)
Bioorg Chem (ISSN: 0045-2068linking, 1090-2120electronic), 2020 Jun; 99: 103853-103853.
Impact Factor: 3.119
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Di Natale C, La Manna S, Avitabile C, Florio D, Morelli G, Netti PA, Marasco D
* Engineered β-hairpin scaffolds from human prion protein regions: Structural and functional investigations of aggregates (58 views)
Bioorg Chem (ISSN: 0045-2068linking, 1090-2120electronic), 2020 Mar; 96: 103594-103594.
Impact Factor: 4.831
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Dell'Acqua S, Bacchella C, Monzani E, Nicolis S, Di Natale G, Rizzarelli E, Casella L
* Prion Peptides Are Extremely Sensitive to Copper Induced Oxidative Stress (585 views)
Inorg Chem (ISSN: 0020-1669, 1520-510x, 0020-1669linking), 2017 Sep 18; 56(18): 11317-11325.
Impact Factor: 4.7
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Calvanese L, D'Auria G, Vangone A, Falcigno L, Oliva R
* Analysis of the interface variability in NMR structure ensembles of protein-protein complexes (371 views)
J Struct Biol (ISSN: 1047-8477, 1047-8477linking), 2016 Jun; 194(3): 317-324.
Impact Factor: 2.767
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Maione V, Ruggiero A, Russo L, De Simone A, Pedone PV, Malgieri G, Berisio R, Isernia C
* NMR Structure and Dynamics of the Resuscitation Promoting Factor RpfC Catalytic Domain (355 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2015 Nov 17; 10(11): e0142807-e0142807.
Impact Factor: 3.057
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Di Natale G, Turi I, Pappalardo G, Sóvágó I, Rizzarelli E
* Cross-Talk Between the Octarepeat Domain and the Fifth Binding Site of Prion Protein Driven by the Interaction of Copper(II) with the N-terminus (454 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2015 Mar 2; 21(10): 4071-4084.
Impact Factor: 5.771
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Benetti F, Biarnés X, Attanasio F, Giachin G, Rizzarelli E, Legname G
* Structural determinants in prion protein folding and stability (596 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 0022-2836linking), 2014 Nov 11; 426(22): 3796-3810.
Impact Factor: 4.333
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La Mendola D, Rizzarelli E
* Evolutionary implications of metal binding features in different species' prion protein: an inorganic point of view (354 views)
Biomolecules (ISSN: 2218-273x), 2014 May 23; 4(2): 546-565.
Impact Factor: 2.095
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De Simonea A, Stanzione F, Marasco D, Vitagliano L, Esposito L
* The Intrinsic Stability Of The Human Prion Beta-Sheet Region Investigated By Molecular Dynamics (608 views)
Journal Of Biomolecular Structure & Dynamics, 2013 May 1; 31(5): 441-452.
Impact Factor: 2.983
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Jószai V, Turi I, Kállay C, Pappalardo G, Di Natale G, Rizzarelli E, Sóvágó I
* Mixed metal copper(II)-nickel(II) and copper(II)-zinc(II) complexes of multihistidine peptide fragments of human prion protein (481 views)
J Chem Res (ISSN: 1873-3344, 0162-0134, 0162-0134print), 2012 Jul; 112: 17-24.
Impact Factor: 3.197
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Benetti F, Biarnes X, Attanasio F, Rizzarelli E, Laio A, Legname G
* Description and Characterization of a Highly Stable Enthalpic Intermediate State in Mouse Prion Protein Folding (306 views)
Prion (ISSN: 1933-6896), 2011 Apr; 5: N/D-N/D.
Impact Factor: 2.85
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Kállay C, Turi I, Timári S, Nagy Z, Sanna D, Pappalardo G, De Bona P, Rizzarelli E, Sóvágó I
* The effect of point mutations on copper(II) complexes with peptide fragments encompassing the 106-114 region of human prion protein (503 views)
Monatshefte Fur Chemie (ISSN: 0026-9247), 2011 Apr; 142(4): 411-419.
Impact Factor: 1.532
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Vagliasindi LI, Arena G, Bonomo RP, Pappalardo G, Tabbì G
* Copper complex species within a fragment of the N-terminal repeat region in opossum PrP protein (357 views)
Dalton T (ISSN: 1477-9226, 1477-9234, 1477-9234electronic), 2011 Mar 21; 40(11): 2441-2450.
Impact Factor: 3.838
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Di Natale G, Pappalardo G, Milardi D, Sciacca MF, Attanasio F, La Mendola D, Rizzarelli E
* Membrane interactions and conformational preferences of human and avian prion N-terminal tandem repeats: The role of copper(II) ions, pH, and membrane mimicking environments (494 views)
J Phys Chem B (ISSN: 1520-6106, 1520-5207, 1520-5207electronic), 2010 Nov 4; 114(43): 13830-13838.
Impact Factor: 3.603
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Turi I, Kállay C, Szikszai D, Pappalardo G, Di Natale G, De Bona P, Rizzarelli E, Sóvágó I
* Nickel(II) complexes of the multihistidine peptide fragments of human prion protein (480 views)
J Chem Res (ISSN: 1873-3344, 0162-0134, 0162-0134print), 2010 Sep; 104(8): 885-891.
Impact Factor: 3.317
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Benetti F, Pastorino L, Attanasio F, Rizzarelli E, Legname G
* Insights into Prion Protein Stability (267 views)
Prion (ISSN: 1933-6896), 2010 Jul; 4(3): N/D-N/D.
Impact Factor: 2.468
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La Mendola D, Magrì A, Campagna T, Campitiello MA, Raiola L, Isernia C, Hansson O, Bonomo RP, Rizzarelli E
* A doppel alpha-helix peptide fragment mimics the copper(II) interactions with the whole protein (1115 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2010 Jun 1; 16(21): 6212-6223.
Impact Factor: 5.476
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Di Natale G, Pappalardo G, Milardi D, Sciacca MFM, Attanasio F, La Mendola D, Rizzarelli E
* Different Interactions Of Human And Avian Prion Proteins N-Terminal Tandem Repeat Peptides And Their Copper (ii) Complexes With Model Membranes (385 views)
Journal Of Chemical Physics, 2010; 114: 13830-13838.
Impact Factor: 2.028
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Palladino P, Ronga L, Benedetti E, Rossi F, Ragone R
* Peptide Fragment Approach to Prion Misfolding: The Alpha-2 Domain (401 views)
Int J Pept Res Ther (ISSN: 1573-3149, 0929-5666), 2009 Sep; 15(3): 165-176.
Impact Factor: 0.869
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Pietropaolo A, Muccioli L, Zannoni C, Rizzarelli E
* Conformational preferences of the full chicken prion protein in solution and its differences with respect to mammals (382 views)
Chemphyschem (ISSN: 1439-7641, 1439-4235, 1439-7641electronic), 2009 Jul 13; 10(9-10): 1500-1510.
Impact Factor: 3.453
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La Mendola D, Pietropaolo A, Pappalardo G, Zannoni C, Rizzarelli E
* Prion Proteins Leading to Neurodegeneration (vol 5, pg 579, 2008) (233 views)
Current Alzheimer Research (ISSN: 1567-2050), 2009 Jun; 6(3): N/D-N/D.
Impact Factor: 4.971
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Di Natale G, Osz K, Nagy Z, Sanna D, Micera G, Pappalardo G, Sovago I, Rizzarelli E
* The Interaction Of Copper (ii) With The Prion Peptide Fragment Huprp (76-114) Encompassing Four Histidyl Residues Within And Outside The Octarepeat Domain (323 views)
Inorg Chem (ISSN: 0020-1669, 1520-510x, 1520-510xelectronic), 2009 May 4; 48(9): 4239-4250.
Impact Factor: 4.657
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La Mendola D, Magrì A, Hansson O, Bonomo RP, Rizzarelli E
* Copper(II) complexes with peptide fragments encompassing the sequence 122-130 of human doppel protein (361 views)
Journal Of Inorganic Biochemistry, 2009 May; 103(5): 758-765.
Impact Factor: 3.444
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Bonomo RP, Di Natale G, Rizzarelli E, Tabbì G, Vagliasindi LI
* Copper(II) complexes of prion protein PEG11-tetraoctarepeat fragment: spectroscopic and voltammetric studies (411 views)
Dalton T (ISSN: 1477-9226, 1477-7922, 1477-9234), 2009 Apr 14; (14): 2637-2646.
Impact Factor: 2.908
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Ronga L, Palladino P, Ragone R, Benedetti E, Rossi F
* A thermodynamic approach to the conformational preferences of the 180-195 segment derived from the human prion protein α2-helix (286 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009; 15(1): 30-35.
Impact Factor: 1.807
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La Mendola D, Pietropaolo A, Pappalardo G, Zannoni C, Rizzarelli E
* Prion proteins leading to neurodegeneration (420 views)
Current Alzheimer Research (ISSN: 1567-2050), 2008 Dec; 5(6): 579-590.
Impact Factor: 4.132
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Bonomo RP, Pappalardo G, Rizzarelli E, Tabbì G, Vagliasindi LI
* Studies of nitric oxide interaction with mono- and dinuclear copper(II) complexes of prion protein bis-octarepeat fragments (309 views)
Dalton T (ISSN: 1477-9226, 1477-9234, 1477-9234electronic), 2008 Sep 7; (29): 3805-3816.
Impact Factor: 3.58
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Pietropaolo A, Muccioli L, Zannoni C, La Mendola D, Maccarrone G, Pappalardo G, Rizzarelli E
* Unveiling the role of histidine and tyrosine residues on the conformation of the avian prion hexarepeat domain (343 views)
J Phys Chem B (ISSN: 1520-6106, 1520-5207, 1520-5207electronic), 2008 Apr 24; 112(16): 5182-5188.
Impact Factor: 4.189
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Colangelo AM, Bianco MR, Vitagliano L, Cavaliere C, Cirillo G, De Gioia L, Diana D, Colombo D, Redaelli C, Zaccaro L, Morelli G, Papa M, Sarmientos P, Alberghina L, Martegani E
* A New Nerve Growth Factor (ngf)-Mimetic Peptide Active On Neuropathic Pain In Rats (657 views)
J Neurosci (ISSN: 0270-6474, 0270-0647, 1529-2401), 2008 Mar 12; 28(11): 2698-2709.
Impact Factor: 7.452
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De Simone A, Pedone C, Vitagliano L
* Structure, dynamics, and stability of assemblies of the human prion fragment SNQNNF (503 views)
Biochem Biophys Res Commun (ISSN: 1090-2104, 0006-291x, 1090-2104electronic), 2008 Feb 15; 366(3): 800-806.
Impact Factor: 2.648
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Bonomo RP, Pappalardo G, Rizzarelli E, Santoro AM, Tabbì G, Vagliasindi LI
* Nitrogen oxide interaction with copper complexes formed by small peptides belonging to the prion protein octa-repeat region (562 views)
Dalton T (ISSN: 1477-9226, 1477-9234, 1477-9234electronic), 2007 Apr 14; (14): 1400-1408.
Impact Factor: 3.212
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Ronga L, Langella E, Palladino P, Marasco D, Tizzano B, Saviano M, Pedone C, Improta R, Ruvo M
* Does Tetracycline Bind Helix 2 Of Prion? An Integrated Spectroscopical And Computational Study Of The Interaction Between The Antibiotic And Alpha Helix 2 Human Prion Protein Fragments (512 views)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2007 Feb 15; 66(3): 707-715.
Impact Factor: 3.354
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Ronga L, Palladino P, Costantini S, Facchiano A, Ruvo M, Benedetti E, Ragone R, Rossi F
* Conformational diseases and structure-toxicity relationships: Lessons from prion-derived peptides (553 views)
Curr Protein Pept Sci (ISSN: 1389-2037, 1389-2037linking), 2007 Feb; 8(1): 83-90.
Impact Factor: 3.259
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Rao M, Russo F, Granata V, Berisio R, Zagari A, Gianfreda L
* Fate of prions in soil: Interaction of a recombinant ovine prion protein with synthetic humic-like mineral complexes (426 views)
Soil Biol Biochem (ISSN: 0038-0717), 2007 Feb; 39(2): 493-504.
Impact Factor: 2.58
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Osz K, Nagy Z, Pappalardo G, Di Natale G, Sanna D, Micera G, Rizzarelli E, Sóvágó I
* Copper(II) interaction with prion peptide fragments encompassing histidine residues within and outside the octarepeat domain: speciation, stability constants and binding details (549 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2007; 13(25): 7129-7143.
Impact Factor: 5.33
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Ronga L, Palladino P, Saviano G, Tancredi T, Benedetti E, Ragone R, Rossi F
* NMR structure and CD titration with metal cations of human prion α2-helix-related peptides (465 views)
Bioinorg Chem Appl (ISSN: 1565-3633), 2007; 2007: N/D-N/D.
Impact Factor: 0.978
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Pappalardo M, Milardi D, Grasso D, La Rosa C
* Steered molecular dynamics studies reveal different unfolding pathways of prions from mammalian and non-mammalian species (338 views)
New J Chem (ISSN: 1144-0546), 2007; 31(6): 901-905.
Impact Factor: 2.651
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Ronga L, Palladino P, Tizzano B, Marasco D, Benedetti E, Ragone R, Rossi F
* Effect of salts on the structural behavior of hPrP α2-helix-derived analogues: The counterion perspective (454 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2006 Dec; 12(12): 790-795.
Impact Factor: 1.801
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Esposito L, Pedone C, Vitagliano L
* Molecular dynamics analyses of cross-beta-spine steric zipper models: beta-sheet twisting and aggregation (727 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2006 Sep 1; 103(31): 11533-11538.
Impact Factor: 9.643
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De Luca S, Saviano M, Della Moglie R, Digilio G, Bracco C, Aloj L, Tarallo L, Pedone C, Morelli G
* Conformationally constrained CCK8 analogues obtained from a rationally designed peptide library as ligands for cholecystokinin type B receptor (421 views)
Chemmedchem (ISSN: 1860-7179, 1860-7187, 1860-7187electronic), 2006 Sep; 1(9): 997-1006.
Impact Factor: 3.046
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Ronga L, Tizzano B, Palladino P, Ragone R, Urso E, Maffia M, Ruvo M, Benedetti E, Rossi F
* The prion protein: structural features and related toxic peptides (529 views)
Chem Biol Drug Des (ISSN: 1747-0277, 1747-0285), 2006 Sep; 68(3): 139-147.
Impact Factor: 2.507
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Joszal V, Nagy Z, Osz K, Sanna D, Di Natale G, La Mendola D, Pappalardo G, Rizzarelli E, Sovago I
* Transition metal complexes of terminally protected peptides containing histidyl residues (513 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2006 Sep; 100(8): 1399-1409.
Impact Factor: 2.654
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Langella E, Improta R, Crescenzi O, Barone V
* Assessing the acid-base and conformational properties of histidine residues in human prion protein (125-228) by means of pKα calculations and molecular dynamics simulations (581 views)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2006 Jul 1; 64(1): 167-177.
Impact Factor: 3.73
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Granata V, Palladino P, Tizzano B, Negro A, Berisio R, Zagari A
* The effect of the osmolyte trimethylamine N-oxide on the stability of the prion protein at low pH (402 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2006 Jun 15; 82(3): 234-240.
Impact Factor: 2.48
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Palladino P, Ronga L, Tizzano B, Rossi F, Ragone R, Tancredi T, Saviano G, Facchiano A, Costantini S, Ruvo M, Benedetti E
* Prion protein misfolding: Conformational stability of the alpha 2-helix (289 views)
Understanding Biology Using Peptides, 2006; N/D: N/D-N/D.
Impact Factor: 2.614
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Grasso D, Grasso G, Guantieri V, Impellizzeri G, La Rosa C, Milardi D, Micera G, Osz K, Pappalardo G, Rizzarelli E, Sanna D, Sovago I
* Environmental effects on a prion's helix II domain: copper(II) and membrane interactions with PrP180-193 and its analogues (432 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2005 Dec 23; 12(2): 537-547.
Impact Factor: 4.907
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La Mendola D, Bonomo RP, Impellizzeri G, Maccarrone G, Pappalardo G, Pietropaolo A, Rizzarelli E, Zito V
* Copper(II) complexes with chicken prion repeats: Influence of proline and tyrosine residues on the coordination features (303 views)
J Biol Inorg Chem (ISSN: 0949-8257, 1432-1327electronic, 0949-8257print), 2005 Sep; 10(5): 463-475.
Impact Factor: 3.224
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Tizzano B, Palladino P, De Capua A, Marasco D, Rossi F, Benedetti E, Pedone C, Ragone R, Ruvo M
* The Human Prion Protein Alpha2 Helix: A Thermodynamic Study Of Its Conformational Preferences (504 views)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2005 Apr 1; 59(1): 72-79.
Impact Factor: 4.684
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Di Natale G, Impellizzeri G, Pappalardo G
* Conformational properties of peptide fragments homologous to the 106-114 and 106-126 residues of the human prion protein: a CD and NMR spectroscopic study (424 views)
Org Biomol Chem (ISSN: 1477-0520, 1477-0539, 1477-0539electronic), 2005 Feb 7; 3(3): 490-497.
Impact Factor: 2.547
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Bonomo RP, Cucinotta V, Giuffrida A, Impellizzeri G, Magrì A, Pappalardo G, Rizzarelli E, Santoro AM, Tabbì G, Vagliasindi LI
* A re-investigation of copper coordination in the octa-repeats region of the prion protein (376 views)
Dalton T (ISSN: 1477-9226, 1477-9234, 1477-9234electronic), 2005 Jan 7; (1): 150-158.
Impact Factor: 3.003
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Langella E, Improta R, Barone V
* Checking the pH-induced conformational transition of prion protein by molecular dynamics simulations: Effect of protonation of histidine residues (427 views)
Biophysical Journal (ISSN: 0006-3495, 1542-0086), 2004 Dec; 87(6): 3623-3632.
Impact Factor: 4.585
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Pappalardo M, Milardi D, La Rosa C, Zannoni C, Rizzarelli E, Grasso D
* A molecular dynamics study on the conformational stability of PrP 180-193 helix II prion fragment (306 views)
Chem Phys Lett (ISSN: 0009-2614), 2004 Jun 1; 390(4-6): 511-516.
Impact Factor: 2.438
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Grasso D, Milardi D, La Rosa C, Rizzarelli E
* The different role of Cu++ and Zn++ ions in affecting the interaction of prion peptide PrP106-126 with model membranes (283 views)
Chem Commun (ISSN: 1359-7345, 1364-548x, 1364-548xelectronic), 2004 Jan 21; 10(2): 246-247.
Impact Factor: 3.997
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Brown DR, Guantieri V, Grasso G, Impellizzeri G, Pappalardo G, Rizzarelli E
* Copper(II) complexes of peptide fragments of the prion protein. Conformation changes induced by copper(II) and the binding motif in C-terminal protein region (495 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2004 Jan; 98(1): 133-143.
Impact Factor: 2.225
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Barone V, Improta R, Rega N
* Computation of protein pK's values by an integrated density functional theory/Polarizable Continuum Model approach (288 views)
Theor Chem Acc (ISSN: 1432-881x), 2004; 111(2-6): 237-245.
Impact Factor: 2.209
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Tizzano B, Marasco D, Benedetti E, De Capua A, Palladino P, Pedone C, Perretta G, Rossi F, Ragone R, Ruvo M
* Conformational conversion of prion proteins: Role synthetic PRP 173-195 fibrillogenic peptide (354 views)
Peptide Revolution, 2004; N/D: N/D-N/D.
Impact Factor: 4.659
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Pappalardo G, Impellizzeri G, Campagna T
* Copper(II) binding of prion protein's octarepeat model peptides (505 views)
Inorg Chim Acta (ISSN: 0020-1693), 2004; 357(1): 185-194.
Impact Factor: 1.554
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De Luca S, Ragone R, Bracco C, Digilio G, Aloj L, Tesauro D, Saviano M, Pedone C, Morelli G
* A cyclic CCK8 analogue selective for the cholecystokinin type A receptor: design, synthesis, NMR structure and binding measurements (472 views)
Chembiochem (ISSN: 1439-7633, 1439-4227, 1439-7633electronic), 2003 Nov 7; 4(11): 1176-1187.
Impact Factor: 3.992
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La Mendola D, Bonomo R, Maccarrone G, Pappalardo G, Rizzarelli E
* A thermodynamic and spectroscopic study on the copper(II) complexes with hexarepeats fragments of the avian prion protein (324 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2003 Jul 15; 96(1): N/D-N/D.
Impact Factor: 2.343
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Isernia C, Bucci E, Leone M, Zaccaro L, Di Lello P, Digilio G, Esposito S, Saviano M, Di Blasio B, Pedone C, Pedone PV, Fattorusso R
* NMR structure of the single QALGGH zinc finger domain from the Arabidopsis thaliana SUPERMAN protein (429 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2003 Mar 3; 4(2-3): 171-180.
Impact Factor: 3.992
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Bonomo RP, Grasso D, Grasso G, Guantieri V, Impellizzeri G, La Rosa C, Milardi D, Pappalardo G, Tabbì G, Rizzarelli E
* Metal binding to prion protein (269 views)
Metal-Ligand Interactions - Molecular Nano- Micro- And Macro-Systems In Complex Environments, 2003 Jan 01; 116: 21-39.
Impact Factor: 5.664
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Grasso D, Milardi D, Guantieri V, La Rosa C, Rizzarelli E
* Interaction of prion peptide PrP 180-193 with DPPC model membranes: A thermodynamic study (383 views)
New J Chem (ISSN: 1144-0546), 2003; 27(2): 359-364.
Impact Factor: 2.272
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Menziani MC, De Benedetti PG, Langella E, Barone V
* Seeking for binding determinants of the prion protein to human plasminogen (391 views)
Mol Phys (ISSN: 0026-8976), 2003; 101(17): 2763-2773.
Impact Factor: 1.591
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Grasso D, Milardi D, La Rosa C, Rizzarelli E
* DSC study of the interaction of the prion peptide PrP106-126 with artificial membranes (377 views)
New J Chem (ISSN: 1144-0546), 2001; 25(12): 1543-1548.
Impact Factor: 2.44
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Bonomo RP, Imperllizzeri G, Pappalardo G, Rizzarelli E, Tabbì G
Copper(II) binding modes in the prion octapeptide PHGGGWGQ: A spectroscopic and voltammetric study (502 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2000 Nov 17; 6(22): 4195-4202.
Impact Factor: 4.698
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66 Records (59 excluding Abstracts).
Total impact factor: 227.349 (206.466 excluding Abstracts).
Total 5 year impact factor: 236.967 (214.11 excluding Abstracts).
Total impact factor: 227.349 (206.466 excluding Abstracts).
Total 5 year impact factor: 236.967 (214.11 excluding Abstracts).
411 views. Last view on Saturday 14 January 2023, 19:20:22
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