TGF-β1 protects against Aβ-neurotoxicity via the phosphatidylinositol-3-kinase pathway (363 views)
Neurobiology Of Disease (ISSN: 0969-9961), 2008 May; 30(2): 234-242.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 4.852, 5-year impact factor: 4.729
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-43049116103&partnerID=40&md5=053db8be0e9b830b29176c0c1ba4f992
Keywords: β-Catenin, Amyloid, Cell Cycle, Hippocampus, Neuronal Death, Pi-3-K, Sb431542, Tgf-β1, 2 Morpholino 8 Phenylchromone, 4 [4 (1, 3 Benzodioxol 5 Yl) 5 (2 Pyridinyl) 1h Imidazol 2 Yl]benzamide, Amyloid Beta Protein, Beta Catenin, Ly 294402, Phosphatidylinositol 3 Kinase, Phosphatidylinositol 3 Kinase Inhibitor, Tau Protein, Transforming Growth Factor Beta1, Animal Experiment, Animal Model, Animal Tissue, Article, Brain Cell, Cell Activation, Controlled Study, Nerve Cell Necrosis, Neuroprotection, Neurotoxicity, Nonhuman, Priority Journal, Protein Degradation, Protein Phosphorylation, Rodent, 1-Phosphatidylinositol 3-Kinase, Amyloid Beta-Protein, Cultured, Neuroprotective Agents, Wistar, Signal Transduction, 3 Benzodioxol 5 Yl) 5 (2 Pyridinyl) 1h Imidazol 2 Yl] Benzamide,
Affiliations:
*** IBB - CNR ***
Department of Pharmaceutical Sciences, University of Catania, 95125 Catania, Italy
I.N.M. Neuromed, Localita Camerelle, 86077, Pozzilli, Italy
IRCCS Associazione Oasi Maria S.S., Institute for Research on Mental Retardation and Brain Aging, 94018 Troina, Enna, Italy
Department of Experimental and Clinical Pharmacology, University of Catania, 95125 Catania, Italy
Department of Human Physiology and Pharmacology, University of Rome La Sapienza, 00185 Rome, Italy
I.B.B., CNR-Catania, 95125 Catania, Italy
I. N. M. Neuromed, Localita Camerelle, 86077, Pozzilli, Italy
I. B. B., CNR-Catania, 95125 Catania, Italy
References:
Brazil, D.P., Hemmings, B.A., Ten years of protein kinase B signalling: a hard Akt to follow (2001) Trends Biochem. Sci., 26, pp. 657-66
Brinton, R.D., Impact of estrogen therapy on Alzheimer's disease: a fork in the road? (2004) CNS Drugs, 18, pp. 405-422
Brionne, T.C., Tesseur, I., Masliah, E., Wyss Coray, T., Loss of TGF-β1 leads to increased neuronal cell death and microgliosis in mouse brain (2003) Neuron, 40, pp. 1133-1145
Bruno, V., Battaglia, G., Casabona, G., Copani, A., Caciagli, F., Nicoletti, F., Neuroprotection by glial metabotropic glutamate receptors is mediated by transforming growth factor-beta (1998) J. Neurosci., 18, pp. 9594-9600
Butterfield, D.A., Reed, T., Newman, S.F., Sultana, R., Roles of amyloid beta-peptide-associated oxidative stress and brain protein modifications in the pathogenesis of Alzheimer's disease and mild cognitive impairment (2007) Free Radic. Biol. Med., 43, pp. 658-677
Caricasole, A., Copani, A., Caraci, F., Aronica, E., Rozemuller, A.J., Caruso, A., Storto, M., Nicoletti, F., Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain (2004) J. Neurosci., 24, pp. 6021-6027
Castren, E., Tanila, H., Neurotrophins and dementia-keeping in touch (2006) Neuron, 51, pp. 1-3
Chalmers, K.A., Love, S., Neurofibrillary tangles may interfere with Smad 2/3 signaling in neurons (2007) J. Neuropathol. Exp. Neurol., 66, pp. 158-167
Connor, B., Dragunow, M., The role of neuronal growth factors in neurodegenerative disorders of the human brain (1998) Brain Res. Brain Res. Rev., 27, pp. 1-39
Copani, A., Bruno, V., Battaglia, G., Lenza, G., Pellitteri, R., Russo, A., Stanzani, S., Nicoletti, F., Activation of metabotropic glutamate receptors protects cultured neurons against apoptosis induced by beta-amyloid peptide (1995) Mol. Pharmacol., 47, pp. 890-897
Copani, A., Condorelli, F., Caruso, A., Vancheri, C., Sala, A., Giuffrida Stella, A.M., Canonico, P.L., Sortino, M.A., Mitotic signaling by beta-amyloid causes neuronal death (1999) FASEB J., 13, pp. 2225-2234
Copani, A., Sortino, M.A., Caricasole, A., Chiechio, S., Chisari, M., Battaglia, G., Giuffrida-Stella, A.M., Nicoletti, F., Erratic expression of DNA polymerases by beta-amyloid causes neuronal death (2002) FASEB J., 16, pp. 2006-2008
Copani, A., Hoozemans, J.J., Caraci, F., Calafiore, M., Van Haaster, E.S., Veerhius, R., Rozemuller, A.J.M., Nicoletti, F., DNA polymerase-β is early expressed in neurons of Alzheimer's Disease brain and is loaded into DNA replication forks in neurons challenged with β-amyloid (2006) J. Neurosci., 26, pp. 10949-10957
Demuro, A., Mina, E., Kayed, R., Milton, S.C., Parker, I., Glabe, C.G., Calcium dysregulation and membrane disruption as a ubiquitous neurotoxic mechanism of soluble amyloid oligomers (2005) J. Biol. Chem., 280, pp. 17294-17300
Derynck, R., Zhang, Y.E., Smad-dependent and Smad-independent pathways in TGF-beta family signalling (2003) Nature, 425, pp. 577-584
Fuentealba, R.A., Farias, G., Scheu, J., Bronfman, M., Marzolo, M.P., Inestrosa, N.C., Signal transduction during amyloid-beta-peptide neurotoxicity: role in Alzheimer disease (2004) Brain Res. Brain Res. Rev., 47, pp. 275-289
Gaertner, R.F., Wyss-Coray, T., Von Euw, D., Lesne, S., Vivien, D., Lacombe, P., Reduced brain tissue perfusion in TGF-beta 1 transgenic mice showing Alzheimer's disease-like cerebrovascular abnormalities (2005) Neurobiol. Dis., 19, pp. 38-46
Garcia, Z., Kumar, A., Marques, M., Cortes, I., Carrera, A.C., Phosphoinositide 3-kinase controls early and late events in mammalian cell division (2006) EMBO J., 25, pp. 655-661
Giovanni, A., Wirtz-Brugger, F., Keramaris, E., Slack, R., Park, D.S., Involvement of cell cycle elements, cyclin-dependent kinases, pRb, and E2F-DP, in β-amyloid-induced neuronal death (1999) J. Biol. Chem., 274, pp. 19011-19016
Giuffrida, M.L., Grasso, G., Ruvo, M., Pedone, C., Saporito, A., Marasco, D., Pignataro, B., Rizzarelli, E., Abeta(25-35) and its C- and/or N-blocked derivatives: copper driven structural features and neurotoxicity (2007) J. Neurosc. Res., 85, pp. 623-633
Grammas, P., Ovase, R., Cerebrovascular transforming growth factor-β contributes to inflammation in the Alzheimer's disease brain (2002) Am. J. Pathol., 160, pp. 1583-1587
Hardy, J., Selkoe, D.J., The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics (2002) Science, 297, pp. 353-356
Harris-White, M.E., Chu, T., Balverde, Z., Sigel, J.J., Flanders, K.C., Frautschy, S.A., Effects of transforming growth factor-beta (isoforms 1-3) on amyloid-beta deposition, inflammation, and cell targeting in organotypic hippocampal slice cultures (1998) J. Neurosci., 18, pp. 10366-10374
Herrup, K., Neve, R., Ackerman, S.L., Copani, A., Divide and die: cell cycle events as triggers of nerve cell death (2004) J. Neurosci., 24, pp. 9232-9239
Hock Jr., B.J., Lamb, B.T., Transgenic mouse models of Alzheimer's disease (2001) Trends Genet., 17, pp. S7-S12
Hynd, M.R., Scott, H.L., Dodd, P.R., Glutamate-mediated excitotoxicity and neurodegeneration in Alzheimer's disease (2004) Neurochem. Int., 45, pp. 583-595
Inman, G.J., Nicolas, F.J., Callahan, J.F., Harling, J.D., Gaster, L.M., Reith, A.D., Laping, N.J., Hill, C.S., SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7 (2002) Mol. Pharmacol., 62, pp. 65-74
Kihara, T., Shimohama, S., Sawada, H., Honda, K., Nakamizo, T., Shibasaki, H., Kume, T., Akaike, A., alpha 7 nicotinic receptor transduces signals to phosphatidylinositol 3-kinase to block A beta-amyloid-induced neurotoxicity (2001) J. Biol. Chem., 276, pp. 13541-13546
Kim, E.S., Kim, R.S., Ren, R.F., Hawver, D.B., Flanders, K.C., Transforming growth factor-beta inhibits apoptosis induced by beta-amyloid peptide fragment 25-35 in cultured neuronal cells (1998) Brain Res. Mol. Brain Res., 62, pp. 122-130
Lai, Y.L., Smith, P.M., Lamm, W.J.E., Hildebrandt, J., Sampling and analysis of cerebrospinal fluid for chronic studies in awake rats (1983) J. Appl. Physiol., 54, pp. 1754-1757
Lee, H.G., Ueda, M., Zhu, X., Perry, G., Smith, M.A., Ectopic expression of phospho-Smad2 in Alzheimer's disease: uncoupling of the transforming growth factor-beta pathway? (2006) J. Neurosci. Res., 84, pp. 1856-1861
Luterman, J.D., Haroutunian, V., Yemul, S., Ho, L., Purohit, D., Aisen, P.S., Mohs, R., Pasinetti, G.M., Cytokine gene expression as a function of the clinical progression of Alzheimer disease dementia (2000) Arch. Neurol., 57, pp. 1153-1160
Makwana, M., Jones, L.L., Cuthill, D., Heike Heuer, H., Bohatschek, M., Hristova, M., Friedrichsen, S., Raivich, G., Endogenous transforming growth factor β1 suppresses inflammation and promotes survival in adult CNS (2007) J. Neurosci., 27, pp. 11201-11213
Malin, D.H., Crothers, M.K., Lake, J.R., Goyarzu, P., Plotner, R.E., Garcia, S.A., Spell, S.H., Kowall, N.W., Hippocampal injections of amyloid beta-peptide 1-40 impair subsequent one-trial/day reward learning (2001) Neurobiol. Learn. Mem., 76, pp. 125-137
Mattson, M.P., Cheng, B., Davis, D., Bryant, K., Lieberburg, I., Rydel, R.E., beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity (1992) J. Neurosci., 12, pp. 376-389
Miguel-Hidalgo, J.J., Cacabelos, R., Beta-amyloid(1-40)-induced neurodegeneration in the rat hippocampal neurons of the CA1 subfield (1998) Acta Neuropathol. (Berl), 95, pp. 455-465
Morimoto, K., Yoshimi, K., Tonohiro, T., Yamada, N., Oda, T., Kaneko, I., Co-injection of beta-amyloid with ibotenic acid induces synergistic loss of rat hippocampal neurons (1998) Neuroscience, 84, pp. 479-487
Murase, S., Mosser, E., Schuman, E.M., Depolarization drives beta-catenin into neuronal spines promoting changes in synaptic structure and function (2002) Neuron., 35, pp. 91-105
Pike, C.J., Burdick, D., Walencewicz, A.J., Glabe, C.G., Cotman, C.W., Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state (1993) J. Neurosci., 13, pp. 1676-1687
Prehn, J.H., Bindokas, V.P., Jordan, J., Galindo, M.F., Ghadge, G.D., Roos, R.P., Boise, L.H., Miller, R.J., Protective effect of transforming growth factor-beta 1 on beta-amyloid neurotoxicity in rat hippocampal neurons (1996) Mol. Pharmacol., 49, pp. 319-328
Ren, R.F., Flanders, K.C., Transforming growth factors-beta protect primary rat hippocampal neuronal cultures from degeneration induced by beta-amyloid peptide (1996) Brain Res., 732, pp. 16-24
Rossig, L., Badorff, C., Holzmann, Y., Zeiher, A.M., Dimmeler, S., Glycogen synthase kinase-3 couples AKT-dependent signaling to the regulation of p21 Cip1 degradation (2002) J. Biol. Chem., 277, pp. 9684-9689
Shapiro, G.I., Preclinical and clinical development of the cyclin-dependent kinase inhibitor flavopiridol (2004) Clin. Cancer Res., 10, pp. 4270-4275
Shaw, M., Cohen, P., Alessi, D.R., Further evidence that the inhibition of glycogen synthase kinase-3beta by IGF-1 is mediated by PDK1/PKB-induced phosphorylation of Ser-9 and not by dephosphorylation of Tyr-216 (1997) FEBS Lett., 416, pp. 307-311
Sortino, M.A., Chisari, M., Merlo, S., Vancheri, C., Caruso, M., Nicoletti, F., Canonico, P.L., Copani, A., Glia mediates the neuroprotective action of estradiol on beta-amyloid-induced neuronal death (2004) Endocrinology, 145, pp. 5080-5086
Swanson, C.J., Bures, M., Johnson, M.P., Linden, A.M., Monn, J.A., Schoepp, D.D., Metabotropic glutamate receptors as novel targets for anxiety and stress disorders (2005) Nat. Rev., Drug Discov., 4, pp. 131-144
Takashima, A., Honda, T., Yasutake, K., Michel, G., Murayama, O., Murayama, M., Ishiguro, K., Yamaguchi, H., Activation of tau protein kinase I/glycogen synthase kinase-3beta by amyloid beta peptide (25-35) enhances phosphorylation of tau in hippocampal neurons (1998) Neurosci Res., 31, pp. 317-323
Takashima, A., Murayama, M., Murayama, O., Kohno, T., Honda, T., Yasutake, K., Nihonmatsu, N., Wolozin, B., Presenilin 1 associates with glycogen synthase kinase-3beta and its substrate tau (1998) Proc. Natl. Acad. Sci. U. S. A., 95, pp. 9637-9641
Ten Dijke, P., Hill, C.S., New insights into TGF-beta-Smad signalling (2004) Trends Biochem. Sci., 29, pp. 265-273
Tesseur, I., Zou, K., Esposito, L., Bard, F., Berber, E., Can, J.V., Lin, A.H., Wyss-Coray, T., Deficiency in neuronal TGF-beta signaling promotes neurodegeneration and Alzheimer's pathology (2006) J. Clin. Invest., 116, pp. 3060-3069
Ueberham, U., Ueberham, E., Gruschka, H., Arendt, T., Altered subcellular location of phosphorylated Smads in Alzheimer's disease (2006) Eur. J. Neurosci., 24, pp. 2327-2334
Wyss-Coray, T., Tgf-Beta pathway as a potential target in neurodegeneration and Alzheimer's (2006) Curr. Alzheimer Res., 3, pp. 191-195
Wyss-Coray, T., Masliah, E., Mallory, M., McConlogue, L., Johnson-Wood, K., Lin, C., Mucke, L., Amyloidogenic role of cytokine TGF-β1 in transgenic mice and Alzheimer's disease (1997) Nature, 389, pp. 603-606
Yu, X., Malenka, R.C., Beta-catenin is critical for dendritic morphogenesis (2003) Nat. Neurosci., 6, pp. 1169-1177
Zhang, L., Rubinow, D.R., Xaing, G., Li, B.S., Chang, Y.H., Maric, D., Barker, J.L., Ma, W., Estrogen protects against beta-amyloid-induced neurotoxicity in rat hippocampal neurons by activation of Akt (2001) Neuroreport, 12, pp. 1919-1923
Zhang, H., Zou, K., Tesseur, I., Wyss-Coray, T., Small molecule tgf-beta mimetics as potential neuroprotective factors (2005) Curr. Alzheimer Res., 2, pp. 183-186
Zhu, Y., Culmsee, C., Klumpp, S., Krieglstein, J., Neuroprotection by transforming growth factor-beta1 involves activation of nuclear factor-kappaB through phosphatidylinositol-3-OH kinase/Akt and mitogen-activated protein kinase-extracellular-signal regulated kinase1,2 signaling pathways (2004) Neuroscience, 123, pp. 897-906
Brazil, D. P., Hemmings, B. A., Ten years of protein kinase B signalling: a hard Akt to follow (2001) Trends Biochem. Sci., 26, pp. 657-66
Brinton, R. D., Impact of estrogen therapy on Alzheimer's disease: a fork in the road? (2004) CNS Drugs, 18, pp. 405-422
Brionne, T. C., Tesseur, I., Masliah, E., Wyss Coray, T., Loss of TGF- 1 leads to increased neuronal cell death and microgliosis in mouse brain (2003) Neuron, 40, pp. 1133-1145
Butterfield, D. A., Reed, T., Newman, S. F., Sultana, R., Roles of amyloid beta-peptide-associated oxidative stress and brain protein modifications in the pathogenesis of Alzheimer's disease and mild cognitive impairment (2007) Free Radic. Biol. Med., 43, pp. 658-677
Chalmers, K. A., Love, S., Neurofibrillary tangles may interfere with Smad 2/3 signaling in neurons (2007) J. Neuropathol. Exp. Neurol., 66, pp. 158-167
Fuentealba, R. A., Farias, G., Scheu, J., Bronfman, M., Marzolo, M. P., Inestrosa, N. C., Signal transduction during amyloid-beta-peptide neurotoxicity: role in Alzheimer disease (2004) Brain Res. Brain Res. Rev., 47, pp. 275-289
Gaertner, R. F., Wyss-Coray, T., Von Euw, D., Lesne, S., Vivien, D., Lacombe, P., Reduced brain tissue perfusion in TGF-beta 1 transgenic mice showing Alzheimer's disease-like cerebrovascular abnormalities (2005) Neurobiol. Dis., 19, pp. 38-46
Giuffrida, M. L., Grasso, G., Ruvo, M., Pedone, C., Saporito, A., Marasco, D., Pignataro, B., Rizzarelli, E., Abeta (25-35) and its C- and/or N-blocked derivatives: copper driven structural features and neurotoxicity (2007) J. Neurosc. Res., 85, pp. 623-633
Harris-White, M. E., Chu, T., Balverde, Z., Sigel, J. J., Flanders, K. C., Frautschy, S. A., Effects of transforming growth factor-beta (isoforms 1-3) on amyloid-beta deposition, inflammation, and cell targeting in organotypic hippocampal slice cultures (1998) J. Neurosci., 18, pp. 10366-10374
Hock Jr., B. J., Lamb, B. T., Transgenic mouse models of Alzheimer's disease (2001) Trends Genet., 17, pp. S7-S12
Hynd, M. R., Scott, H. L., Dodd, P. R., Glutamate-mediated excitotoxicity and neurodegeneration in Alzheimer's disease (2004) Neurochem. Int., 45, pp. 583-595
Inman, G. J., Nicolas, F. J., Callahan, J. F., Harling, J. D., Gaster, L. M., Reith, A. D., Laping, N. J., Hill, C. S., SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7 (2002) Mol. Pharmacol., 62, pp. 65-74
Kim, E. S., Kim, R. S., Ren, R. F., Hawver, D. B., Flanders, K. C., Transforming growth factor-beta inhibits apoptosis induced by beta-amyloid peptide fragment 25-35 in cultured neuronal cells (1998) Brain Res. Mol. Brain Res., 62, pp. 122-130
Lai, Y. L., Smith, P. M., Lamm, W. J. E., Hildebrandt, J., Sampling and analysis of cerebrospinal fluid for chronic studies in awake rats (1983) J. Appl. Physiol., 54, pp. 1754-1757
Lee, H. G., Ueda, M., Zhu, X., Perry, G., Smith, M. A., Ectopic expression of phospho-Smad2 in Alzheimer's disease: uncoupling of the transforming growth factor-beta pathway? (2006) J. Neurosci. Res., 84, pp. 1856-1861
Luterman, J. D., Haroutunian, V., Yemul, S., Ho, L., Purohit, D., Aisen, P. S., Mohs, R., Pasinetti, G. M., Cytokine gene expression as a function of the clinical progression of Alzheimer disease dementia (2000) Arch. Neurol., 57, pp. 1153-1160
Malin, D. H., Crothers, M. K., Lake, J. R., Goyarzu, P., Plotner, R. E., Garcia, S. A., Spell, S. H., Kowall, N. W., Hippocampal injections of amyloid beta-peptide 1-40 impair subsequent one-trial/day reward learning (2001) Neurobiol. Learn. Mem., 76, pp. 125-137
Mattson, M. P., Cheng, B., Davis, D., Bryant, K., Lieberburg, I., Rydel, R. E., beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity (1992) J. Neurosci., 12, pp. 376-389
Miguel-Hidalgo, J. J., Cacabelos, R., Beta-amyloid (1-40) -induced neurodegeneration in the rat hippocampal neurons of the CA1 subfield (1998) Acta Neuropathol. (Berl), 95, pp. 455-465
Pike, C. J., Burdick, D., Walencewicz, A. J., Glabe, C. G., Cotman, C. W., Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state (1993) J. Neurosci., 13, pp. 1676-1687
Prehn, J. H., Bindokas, V. P., Jordan, J., Galindo, M. F., Ghadge, G. D., Roos, R. P., Boise, L. H., Miller, R. J., Protective effect of transforming growth factor-beta 1 on beta-amyloid neurotoxicity in rat hippocampal neurons (1996) Mol. Pharmacol., 49, pp. 319-328
Ren, R. F., Flanders, K. C., Transforming growth factors-beta protect primary rat hippocampal neuronal cultures from degeneration induced by beta-amyloid peptide (1996) Brain Res., 732, pp. 16-24
Shapiro, G. I., Preclinical and clinical development of the cyclin-dependent kinase inhibitor flavopiridol (2004) Clin. Cancer Res., 10, pp. 4270-4275
Sortino, M. A., Chisari, M., Merlo, S., Vancheri, C., Caruso, M., Nicoletti, F., Canonico, P. L., Copani, A., Glia mediates the neuroprotective action of estradiol on beta-amyloid-induced neuronal death (2004) Endocrinology, 145, pp. 5080-5086
Swanson, C. J., Bures, M., Johnson, M. P., Linden, A. M., Monn, J. A., Schoepp, D. D., Metabotropic glutamate receptors as novel targets for anxiety and stress disorders (2005) Nat. Rev., Drug Discov., 4, pp. 131-144
Neurobiology Of Disease (ISSN: 0969-9961), 2008 May; 30(2): 234-242.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 4.852, 5-year impact factor: 4.729
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-43049116103&partnerID=40&md5=053db8be0e9b830b29176c0c1ba4f992
Keywords: β-Catenin, Amyloid, Cell Cycle, Hippocampus, Neuronal Death, Pi-3-K, Sb431542, Tgf-β1, 2 Morpholino 8 Phenylchromone, 4 [4 (1, 3 Benzodioxol 5 Yl) 5 (2 Pyridinyl) 1h Imidazol 2 Yl]benzamide, Amyloid Beta Protein, Beta Catenin, Ly 294402, Phosphatidylinositol 3 Kinase, Phosphatidylinositol 3 Kinase Inhibitor, Tau Protein, Transforming Growth Factor Beta1, Animal Experiment, Animal Model, Animal Tissue, Article, Brain Cell, Cell Activation, Controlled Study, Nerve Cell Necrosis, Neuroprotection, Neurotoxicity, Nonhuman, Priority Journal, Protein Degradation, Protein Phosphorylation, Rodent, 1-Phosphatidylinositol 3-Kinase, Amyloid Beta-Protein, Cultured, Neuroprotective Agents, Wistar, Signal Transduction, 3 Benzodioxol 5 Yl) 5 (2 Pyridinyl) 1h Imidazol 2 Yl] Benzamide,
Affiliations:
*** IBB - CNR ***
Department of Pharmaceutical Sciences, University of Catania, 95125 Catania, Italy
I.N.M. Neuromed, Localita Camerelle, 86077, Pozzilli, Italy
IRCCS Associazione Oasi Maria S.S., Institute for Research on Mental Retardation and Brain Aging, 94018 Troina, Enna, Italy
Department of Experimental and Clinical Pharmacology, University of Catania, 95125 Catania, Italy
Department of Human Physiology and Pharmacology, University of Rome La Sapienza, 00185 Rome, Italy
I.B.B., CNR-Catania, 95125 Catania, Italy
I. N. M. Neuromed, Localita Camerelle, 86077, Pozzilli, Italy
I. B. B., CNR-Catania, 95125 Catania, Italy
References:
Brazil, D.P., Hemmings, B.A., Ten years of protein kinase B signalling: a hard Akt to follow (2001) Trends Biochem. Sci., 26, pp. 657-66
Brinton, R.D., Impact of estrogen therapy on Alzheimer's disease: a fork in the road? (2004) CNS Drugs, 18, pp. 405-422
Brionne, T.C., Tesseur, I., Masliah, E., Wyss Coray, T., Loss of TGF-β1 leads to increased neuronal cell death and microgliosis in mouse brain (2003) Neuron, 40, pp. 1133-1145
Bruno, V., Battaglia, G., Casabona, G., Copani, A., Caciagli, F., Nicoletti, F., Neuroprotection by glial metabotropic glutamate receptors is mediated by transforming growth factor-beta (1998) J. Neurosci., 18, pp. 9594-9600
Butterfield, D.A., Reed, T., Newman, S.F., Sultana, R., Roles of amyloid beta-peptide-associated oxidative stress and brain protein modifications in the pathogenesis of Alzheimer's disease and mild cognitive impairment (2007) Free Radic. Biol. Med., 43, pp. 658-677
Caricasole, A., Copani, A., Caraci, F., Aronica, E., Rozemuller, A.J., Caruso, A., Storto, M., Nicoletti, F., Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain (2004) J. Neurosci., 24, pp. 6021-6027
Castren, E., Tanila, H., Neurotrophins and dementia-keeping in touch (2006) Neuron, 51, pp. 1-3
Chalmers, K.A., Love, S., Neurofibrillary tangles may interfere with Smad 2/3 signaling in neurons (2007) J. Neuropathol. Exp. Neurol., 66, pp. 158-167
Connor, B., Dragunow, M., The role of neuronal growth factors in neurodegenerative disorders of the human brain (1998) Brain Res. Brain Res. Rev., 27, pp. 1-39
Copani, A., Bruno, V., Battaglia, G., Lenza, G., Pellitteri, R., Russo, A., Stanzani, S., Nicoletti, F., Activation of metabotropic glutamate receptors protects cultured neurons against apoptosis induced by beta-amyloid peptide (1995) Mol. Pharmacol., 47, pp. 890-897
Copani, A., Condorelli, F., Caruso, A., Vancheri, C., Sala, A., Giuffrida Stella, A.M., Canonico, P.L., Sortino, M.A., Mitotic signaling by beta-amyloid causes neuronal death (1999) FASEB J., 13, pp. 2225-2234
Copani, A., Sortino, M.A., Caricasole, A., Chiechio, S., Chisari, M., Battaglia, G., Giuffrida-Stella, A.M., Nicoletti, F., Erratic expression of DNA polymerases by beta-amyloid causes neuronal death (2002) FASEB J., 16, pp. 2006-2008
Copani, A., Hoozemans, J.J., Caraci, F., Calafiore, M., Van Haaster, E.S., Veerhius, R., Rozemuller, A.J.M., Nicoletti, F., DNA polymerase-β is early expressed in neurons of Alzheimer's Disease brain and is loaded into DNA replication forks in neurons challenged with β-amyloid (2006) J. Neurosci., 26, pp. 10949-10957
Demuro, A., Mina, E., Kayed, R., Milton, S.C., Parker, I., Glabe, C.G., Calcium dysregulation and membrane disruption as a ubiquitous neurotoxic mechanism of soluble amyloid oligomers (2005) J. Biol. Chem., 280, pp. 17294-17300
Derynck, R., Zhang, Y.E., Smad-dependent and Smad-independent pathways in TGF-beta family signalling (2003) Nature, 425, pp. 577-584
Fuentealba, R.A., Farias, G., Scheu, J., Bronfman, M., Marzolo, M.P., Inestrosa, N.C., Signal transduction during amyloid-beta-peptide neurotoxicity: role in Alzheimer disease (2004) Brain Res. Brain Res. Rev., 47, pp. 275-289
Gaertner, R.F., Wyss-Coray, T., Von Euw, D., Lesne, S., Vivien, D., Lacombe, P., Reduced brain tissue perfusion in TGF-beta 1 transgenic mice showing Alzheimer's disease-like cerebrovascular abnormalities (2005) Neurobiol. Dis., 19, pp. 38-46
Garcia, Z., Kumar, A., Marques, M., Cortes, I., Carrera, A.C., Phosphoinositide 3-kinase controls early and late events in mammalian cell division (2006) EMBO J., 25, pp. 655-661
Giovanni, A., Wirtz-Brugger, F., Keramaris, E., Slack, R., Park, D.S., Involvement of cell cycle elements, cyclin-dependent kinases, pRb, and E2F-DP, in β-amyloid-induced neuronal death (1999) J. Biol. Chem., 274, pp. 19011-19016
Giuffrida, M.L., Grasso, G., Ruvo, M., Pedone, C., Saporito, A., Marasco, D., Pignataro, B., Rizzarelli, E., Abeta(25-35) and its C- and/or N-blocked derivatives: copper driven structural features and neurotoxicity (2007) J. Neurosc. Res., 85, pp. 623-633
Grammas, P., Ovase, R., Cerebrovascular transforming growth factor-β contributes to inflammation in the Alzheimer's disease brain (2002) Am. J. Pathol., 160, pp. 1583-1587
Hardy, J., Selkoe, D.J., The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics (2002) Science, 297, pp. 353-356
Harris-White, M.E., Chu, T., Balverde, Z., Sigel, J.J., Flanders, K.C., Frautschy, S.A., Effects of transforming growth factor-beta (isoforms 1-3) on amyloid-beta deposition, inflammation, and cell targeting in organotypic hippocampal slice cultures (1998) J. Neurosci., 18, pp. 10366-10374
Herrup, K., Neve, R., Ackerman, S.L., Copani, A., Divide and die: cell cycle events as triggers of nerve cell death (2004) J. Neurosci., 24, pp. 9232-9239
Hock Jr., B.J., Lamb, B.T., Transgenic mouse models of Alzheimer's disease (2001) Trends Genet., 17, pp. S7-S12
Hynd, M.R., Scott, H.L., Dodd, P.R., Glutamate-mediated excitotoxicity and neurodegeneration in Alzheimer's disease (2004) Neurochem. Int., 45, pp. 583-595
Inman, G.J., Nicolas, F.J., Callahan, J.F., Harling, J.D., Gaster, L.M., Reith, A.D., Laping, N.J., Hill, C.S., SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7 (2002) Mol. Pharmacol., 62, pp. 65-74
Kihara, T., Shimohama, S., Sawada, H., Honda, K., Nakamizo, T., Shibasaki, H., Kume, T., Akaike, A., alpha 7 nicotinic receptor transduces signals to phosphatidylinositol 3-kinase to block A beta-amyloid-induced neurotoxicity (2001) J. Biol. Chem., 276, pp. 13541-13546
Kim, E.S., Kim, R.S., Ren, R.F., Hawver, D.B., Flanders, K.C., Transforming growth factor-beta inhibits apoptosis induced by beta-amyloid peptide fragment 25-35 in cultured neuronal cells (1998) Brain Res. Mol. Brain Res., 62, pp. 122-130
Lai, Y.L., Smith, P.M., Lamm, W.J.E., Hildebrandt, J., Sampling and analysis of cerebrospinal fluid for chronic studies in awake rats (1983) J. Appl. Physiol., 54, pp. 1754-1757
Lee, H.G., Ueda, M., Zhu, X., Perry, G., Smith, M.A., Ectopic expression of phospho-Smad2 in Alzheimer's disease: uncoupling of the transforming growth factor-beta pathway? (2006) J. Neurosci. Res., 84, pp. 1856-1861
Luterman, J.D., Haroutunian, V., Yemul, S., Ho, L., Purohit, D., Aisen, P.S., Mohs, R., Pasinetti, G.M., Cytokine gene expression as a function of the clinical progression of Alzheimer disease dementia (2000) Arch. Neurol., 57, pp. 1153-1160
Makwana, M., Jones, L.L., Cuthill, D., Heike Heuer, H., Bohatschek, M., Hristova, M., Friedrichsen, S., Raivich, G., Endogenous transforming growth factor β1 suppresses inflammation and promotes survival in adult CNS (2007) J. Neurosci., 27, pp. 11201-11213
Malin, D.H., Crothers, M.K., Lake, J.R., Goyarzu, P., Plotner, R.E., Garcia, S.A., Spell, S.H., Kowall, N.W., Hippocampal injections of amyloid beta-peptide 1-40 impair subsequent one-trial/day reward learning (2001) Neurobiol. Learn. Mem., 76, pp. 125-137
Mattson, M.P., Cheng, B., Davis, D., Bryant, K., Lieberburg, I., Rydel, R.E., beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity (1992) J. Neurosci., 12, pp. 376-389
Miguel-Hidalgo, J.J., Cacabelos, R., Beta-amyloid(1-40)-induced neurodegeneration in the rat hippocampal neurons of the CA1 subfield (1998) Acta Neuropathol. (Berl), 95, pp. 455-465
Morimoto, K., Yoshimi, K., Tonohiro, T., Yamada, N., Oda, T., Kaneko, I., Co-injection of beta-amyloid with ibotenic acid induces synergistic loss of rat hippocampal neurons (1998) Neuroscience, 84, pp. 479-487
Murase, S., Mosser, E., Schuman, E.M., Depolarization drives beta-catenin into neuronal spines promoting changes in synaptic structure and function (2002) Neuron., 35, pp. 91-105
Pike, C.J., Burdick, D., Walencewicz, A.J., Glabe, C.G., Cotman, C.W., Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state (1993) J. Neurosci., 13, pp. 1676-1687
Prehn, J.H., Bindokas, V.P., Jordan, J., Galindo, M.F., Ghadge, G.D., Roos, R.P., Boise, L.H., Miller, R.J., Protective effect of transforming growth factor-beta 1 on beta-amyloid neurotoxicity in rat hippocampal neurons (1996) Mol. Pharmacol., 49, pp. 319-328
Ren, R.F., Flanders, K.C., Transforming growth factors-beta protect primary rat hippocampal neuronal cultures from degeneration induced by beta-amyloid peptide (1996) Brain Res., 732, pp. 16-24
Rossig, L., Badorff, C., Holzmann, Y., Zeiher, A.M., Dimmeler, S., Glycogen synthase kinase-3 couples AKT-dependent signaling to the regulation of p21 Cip1 degradation (2002) J. Biol. Chem., 277, pp. 9684-9689
Shapiro, G.I., Preclinical and clinical development of the cyclin-dependent kinase inhibitor flavopiridol (2004) Clin. Cancer Res., 10, pp. 4270-4275
Shaw, M., Cohen, P., Alessi, D.R., Further evidence that the inhibition of glycogen synthase kinase-3beta by IGF-1 is mediated by PDK1/PKB-induced phosphorylation of Ser-9 and not by dephosphorylation of Tyr-216 (1997) FEBS Lett., 416, pp. 307-311
Sortino, M.A., Chisari, M., Merlo, S., Vancheri, C., Caruso, M., Nicoletti, F., Canonico, P.L., Copani, A., Glia mediates the neuroprotective action of estradiol on beta-amyloid-induced neuronal death (2004) Endocrinology, 145, pp. 5080-5086
Swanson, C.J., Bures, M., Johnson, M.P., Linden, A.M., Monn, J.A., Schoepp, D.D., Metabotropic glutamate receptors as novel targets for anxiety and stress disorders (2005) Nat. Rev., Drug Discov., 4, pp. 131-144
Takashima, A., Honda, T., Yasutake, K., Michel, G., Murayama, O., Murayama, M., Ishiguro, K., Yamaguchi, H., Activation of tau protein kinase I/glycogen synthase kinase-3beta by amyloid beta peptide (25-35) enhances phosphorylation of tau in hippocampal neurons (1998) Neurosci Res., 31, pp. 317-323
Takashima, A., Murayama, M., Murayama, O., Kohno, T., Honda, T., Yasutake, K., Nihonmatsu, N., Wolozin, B., Presenilin 1 associates with glycogen synthase kinase-3beta and its substrate tau (1998) Proc. Natl. Acad. Sci. U. S. A., 95, pp. 9637-9641
Ten Dijke, P., Hill, C.S., New insights into TGF-beta-Smad signalling (2004) Trends Biochem. Sci., 29, pp. 265-273
Tesseur, I., Zou, K., Esposito, L., Bard, F., Berber, E., Can, J.V., Lin, A.H., Wyss-Coray, T., Deficiency in neuronal TGF-beta signaling promotes neurodegeneration and Alzheimer's pathology (2006) J. Clin. Invest., 116, pp. 3060-3069
Ueberham, U., Ueberham, E., Gruschka, H., Arendt, T., Altered subcellular location of phosphorylated Smads in Alzheimer's disease (2006) Eur. J. Neurosci., 24, pp. 2327-2334
Wyss-Coray, T., Tgf-Beta pathway as a potential target in neurodegeneration and Alzheimer's (2006) Curr. Alzheimer Res., 3, pp. 191-195
Wyss-Coray, T., Masliah, E., Mallory, M., McConlogue, L., Johnson-Wood, K., Lin, C., Mucke, L., Amyloidogenic role of cytokine TGF-β1 in transgenic mice and Alzheimer's disease (1997) Nature, 389, pp. 603-606
Yu, X., Malenka, R.C., Beta-catenin is critical for dendritic morphogenesis (2003) Nat. Neurosci., 6, pp. 1169-1177
Zhang, L., Rubinow, D.R., Xaing, G., Li, B.S., Chang, Y.H., Maric, D., Barker, J.L., Ma, W., Estrogen protects against beta-amyloid-induced neurotoxicity in rat hippocampal neurons by activation of Akt (2001) Neuroreport, 12, pp. 1919-1923
Zhang, H., Zou, K., Tesseur, I., Wyss-Coray, T., Small molecule tgf-beta mimetics as potential neuroprotective factors (2005) Curr. Alzheimer Res., 2, pp. 183-186
Zhu, Y., Culmsee, C., Klumpp, S., Krieglstein, J., Neuroprotection by transforming growth factor-beta1 involves activation of nuclear factor-kappaB through phosphatidylinositol-3-OH kinase/Akt and mitogen-activated protein kinase-extracellular-signal regulated kinase1,2 signaling pathways (2004) Neuroscience, 123, pp. 897-906
Brazil, D. P., Hemmings, B. A., Ten years of protein kinase B signalling: a hard Akt to follow (2001) Trends Biochem. Sci., 26, pp. 657-66
Brinton, R. D., Impact of estrogen therapy on Alzheimer's disease: a fork in the road? (2004) CNS Drugs, 18, pp. 405-422
Brionne, T. C., Tesseur, I., Masliah, E., Wyss Coray, T., Loss of TGF- 1 leads to increased neuronal cell death and microgliosis in mouse brain (2003) Neuron, 40, pp. 1133-1145
Butterfield, D. A., Reed, T., Newman, S. F., Sultana, R., Roles of amyloid beta-peptide-associated oxidative stress and brain protein modifications in the pathogenesis of Alzheimer's disease and mild cognitive impairment (2007) Free Radic. Biol. Med., 43, pp. 658-677
Chalmers, K. A., Love, S., Neurofibrillary tangles may interfere with Smad 2/3 signaling in neurons (2007) J. Neuropathol. Exp. Neurol., 66, pp. 158-167
Fuentealba, R. A., Farias, G., Scheu, J., Bronfman, M., Marzolo, M. P., Inestrosa, N. C., Signal transduction during amyloid-beta-peptide neurotoxicity: role in Alzheimer disease (2004) Brain Res. Brain Res. Rev., 47, pp. 275-289
Gaertner, R. F., Wyss-Coray, T., Von Euw, D., Lesne, S., Vivien, D., Lacombe, P., Reduced brain tissue perfusion in TGF-beta 1 transgenic mice showing Alzheimer's disease-like cerebrovascular abnormalities (2005) Neurobiol. Dis., 19, pp. 38-46
Giuffrida, M. L., Grasso, G., Ruvo, M., Pedone, C., Saporito, A., Marasco, D., Pignataro, B., Rizzarelli, E., Abeta (25-35) and its C- and/or N-blocked derivatives: copper driven structural features and neurotoxicity (2007) J. Neurosc. Res., 85, pp. 623-633
Harris-White, M. E., Chu, T., Balverde, Z., Sigel, J. J., Flanders, K. C., Frautschy, S. A., Effects of transforming growth factor-beta (isoforms 1-3) on amyloid-beta deposition, inflammation, and cell targeting in organotypic hippocampal slice cultures (1998) J. Neurosci., 18, pp. 10366-10374
Hock Jr., B. J., Lamb, B. T., Transgenic mouse models of Alzheimer's disease (2001) Trends Genet., 17, pp. S7-S12
Hynd, M. R., Scott, H. L., Dodd, P. R., Glutamate-mediated excitotoxicity and neurodegeneration in Alzheimer's disease (2004) Neurochem. Int., 45, pp. 583-595
Inman, G. J., Nicolas, F. J., Callahan, J. F., Harling, J. D., Gaster, L. M., Reith, A. D., Laping, N. J., Hill, C. S., SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7 (2002) Mol. Pharmacol., 62, pp. 65-74
Kim, E. S., Kim, R. S., Ren, R. F., Hawver, D. B., Flanders, K. C., Transforming growth factor-beta inhibits apoptosis induced by beta-amyloid peptide fragment 25-35 in cultured neuronal cells (1998) Brain Res. Mol. Brain Res., 62, pp. 122-130
Lai, Y. L., Smith, P. M., Lamm, W. J. E., Hildebrandt, J., Sampling and analysis of cerebrospinal fluid for chronic studies in awake rats (1983) J. Appl. Physiol., 54, pp. 1754-1757
Lee, H. G., Ueda, M., Zhu, X., Perry, G., Smith, M. A., Ectopic expression of phospho-Smad2 in Alzheimer's disease: uncoupling of the transforming growth factor-beta pathway? (2006) J. Neurosci. Res., 84, pp. 1856-1861
Luterman, J. D., Haroutunian, V., Yemul, S., Ho, L., Purohit, D., Aisen, P. S., Mohs, R., Pasinetti, G. M., Cytokine gene expression as a function of the clinical progression of Alzheimer disease dementia (2000) Arch. Neurol., 57, pp. 1153-1160
Malin, D. H., Crothers, M. K., Lake, J. R., Goyarzu, P., Plotner, R. E., Garcia, S. A., Spell, S. H., Kowall, N. W., Hippocampal injections of amyloid beta-peptide 1-40 impair subsequent one-trial/day reward learning (2001) Neurobiol. Learn. Mem., 76, pp. 125-137
Mattson, M. P., Cheng, B., Davis, D., Bryant, K., Lieberburg, I., Rydel, R. E., beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity (1992) J. Neurosci., 12, pp. 376-389
Miguel-Hidalgo, J. J., Cacabelos, R., Beta-amyloid (1-40) -induced neurodegeneration in the rat hippocampal neurons of the CA1 subfield (1998) Acta Neuropathol. (Berl), 95, pp. 455-465
Pike, C. J., Burdick, D., Walencewicz, A. J., Glabe, C. G., Cotman, C. W., Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state (1993) J. Neurosci., 13, pp. 1676-1687
Prehn, J. H., Bindokas, V. P., Jordan, J., Galindo, M. F., Ghadge, G. D., Roos, R. P., Boise, L. H., Miller, R. J., Protective effect of transforming growth factor-beta 1 on beta-amyloid neurotoxicity in rat hippocampal neurons (1996) Mol. Pharmacol., 49, pp. 319-328
Ren, R. F., Flanders, K. C., Transforming growth factors-beta protect primary rat hippocampal neuronal cultures from degeneration induced by beta-amyloid peptide (1996) Brain Res., 732, pp. 16-24
Shapiro, G. I., Preclinical and clinical development of the cyclin-dependent kinase inhibitor flavopiridol (2004) Clin. Cancer Res., 10, pp. 4270-4275
Sortino, M. A., Chisari, M., Merlo, S., Vancheri, C., Caruso, M., Nicoletti, F., Canonico, P. L., Copani, A., Glia mediates the neuroprotective action of estradiol on beta-amyloid-induced neuronal death (2004) Endocrinology, 145, pp. 5080-5086
Swanson, C. J., Bures, M., Johnson, M. P., Linden, A. M., Monn, J. A., Schoepp, D. D., Metabotropic glutamate receptors as novel targets for anxiety and stress disorders (2005) Nat. Rev., Drug Discov., 4, pp. 131-144
TGF-β1 protects against Aβ-neurotoxicity via the phosphatidylinositol-3-kinase pathway
β-Amyloid (Aβ) injection into the rat dorsal hippocampus had a small neurotoxic effect that was amplified by i.c.v. injection of SB431542, a selective inhibitor of transforming growth factor-β (TGF-β) receptor. This suggested that TGF-β acts as a factor limiting Aβ toxicity. We examined the neuroprotective activity of TGF-β1 in pure cultures of rat cortical neurons challenged with Aβ. Neuronal death triggered by Aβ is known to proceed along an aberrant re-activation of the cell cycle, and involves late β-catenin degradation and tau hyperphosphorylation. TGF-β1 was equally protective when added either in combination with, or 6 h after Aβ. Co-added TGF-β1 prevented Aβ-induced cell cycle reactivation, whereas lately added TGF-β1 had no effect on the cell cycle, but rescued the late β-catenin degradation and tau hyperphosphorylation. The phosphatidylinositol-3-kinase (PI-3-K) inhibitor, LY294402, abrogated all effects. Thus, TGF-β1 blocks the whole cascade of events leading to Aβ neurotoxicity by activating the PI-3-K pathway. © 2008 Elsevier Inc. All rights reserved.
β-Amyloid (Aβ) injection into the rat dorsal hippocampus had a small neurotoxic effect that was amplified by i.c.v. injection of SB431542, a selective inhibitor of transforming growth factor-β (TGF-β) receptor. This suggested that TGF-β acts as a factor limiting Aβ toxicity. We examined the neuroprotective activity of TGF-β1 in pure cultures of rat cortical neurons challenged with Aβ. Neuronal death triggered by Aβ is known to proceed along an aberrant re-activation of the cell cycle, and involves late β-catenin degradation and tau hyperphosphorylation. TGF-β1 was equally protective when added either in combination with, or 6 h after Aβ. Co-added TGF-β1 prevented Aβ-induced cell cycle reactivation, whereas lately added TGF-β1 had no effect on the cell cycle, but rescued the late β-catenin degradation and tau hyperphosphorylation. The phosphatidylinositol-3-kinase (PI-3-K) inhibitor, LY294402, abrogated all effects. Thus, TGF-β1 blocks the whole cascade of events leading to Aβ neurotoxicity by activating the PI-3-K pathway. © 2008 Elsevier Inc. All rights reserved.
TGF-β1 protects against Aβ-neurotoxicity via the phosphatidylinositol-3-kinase pathway
| ▼ Structural characterization of the porphyrins/proteasome interaction |
TGF-β1 protects against Aβ-neurotoxicity via the phosphatidylinositol-3-kinase pathway
Other filter: ([btitle,keywords] "β-Catenin" OR [btit ...
Ala U, Manco M, Mandili G, Tolosano E, Novelli F, Provero P, Altruda F, Fagoonee S
* Proteomics-Based Evidence for a Pro-Oncogenic Role of ESRP1 in Human Colorectal Cancer Cells (128 views)
Int J Mol Sc (ISSN: 1422-0067linking, 1661-6596, 1422-0067electronic), 2020 Jan 16; 21 (2 ): N/D-N/D.
Impact Factor: 2.598
View Export to BibTeX Export to EndNote
Miceli M, Cutignano A, Conte M, Ummarino R, Romanelli A, Ruvo M, Leone M, Mercurio FA, Doti N, Manzo E, Romano G, Altucci L, Ianora A
* Monoacylglycerides from the Diatom Skeletonema marinoi Induce Selective Cell Death in Cancer Cells (158 views)
Mar Drugs (ISSN: 1660-3397linking), 2019 Nov 1; 17 (11 ): N/D-N/D.
Impact Factor: 3.345
View Export to BibTeX Export to EndNote
Carella A, Roviello V, Iannitti R, Palumbo R, La Manna S, Marasco D, Trifuoggi M, Diana R, Roviello GN
* Evaluating the biological properties of synthetic 4-nitrophenyl functionalized benzofuran derivatives with telomeric DNA binding and antiproliferative activities (397 views)
Int J Biol Macromol (ISSN: 0141-8130linking, 1879-0003electronic), 2019 Jan; 121: 77-88.
Impact Factor: 4.784
View Export to BibTeX Export to EndNote
Petraglia F, Singh AA, Carafa V, Nebbioso A, Conte M, Scisciola L, Valente S, Baldi A, Mandoli A, Petrizzi VB, Ingenito C, De Falco S, Cicatiello V, Apicella I, Janssen-megens EM, Kim B, Yi G, Logie C, Heath S, Ruvo M, Wierenga ATJ, Flicek P, Yaspo ML, Della Valle V, Bernard O, Tomassi S, Novellino E, Feoli A, Sbardella G, Gut I, Vellenga E, Stunnenberg HG, Mai A, Martens JHA, Altucci L
* Combined HAT/EZH2 modulation leads to cancer-selective cell death (284 views)
Oncotarget (ISSN: 1949-2553electronic, 1949-2553linking), 2018 May 22; 9(39): 25630-25646.
Impact Factor: 5.008
View Export to BibTeX Export to EndNote
Di Menna L, Joffe ME, Iacovelli L, Orlando R, Lindsley CW, Mairesse J, Gressèns P, Cannella M, Caraci F, Copani A, Bruno V, Battaglia G, Conn PJ, Nicoletti F
* Functional partnership between mGlu3 and mGlu5 metabotropic glutamate receptors in the central nervous system (395 views)
Neuropharm (ISSN: 0028-3908linking, 1873-7064electronic), 2018 Jan; 128: 301-313.
Impact Factor: 3.383
View Export to BibTeX Export to EndNote
Leggio GM, Catania MV, Puzzo D, Spatuzza M, Pellitteri R, Gulisano W, Torrisi SA, Giurdanella G, Piazza C, Impellizzeri AR, Gozzo L, Navarria A, Bucolo C, Nicoletti F, Palmeri A, Salomone S, Copani A, Caraci F, Drago F
* The antineoplastic drug flavopiridol reverses memory impairment induced by Amyloid-ss1-42 oligomers in mice (466 views)
Pharmacol Res (ISSN: 1043-6618, 1096-1186electronic), 2016 Apr; 106: 10-20.
Impact Factor: 4.48
View Export to BibTeX Export to EndNote
Giuffrida ML, Tomasello MF, Pandini G, Caraci F, Battaglia G, Busceti C, Di Pietro P, Pappalardo G, Attanasio F, Chiechio S, Bagnoli S, Nacmias B, Sorbi S, Vigneri R, Rizzarelli E, Nicoletti F, Copani A
* Monomeric ss-amyloid interacts with type-1 insulin-like growth factor receptors to provide energy supply to neurons (526 views)
Front Cell Neurosci (ISSN: 1662-5102), 2015 Aug 7; 9(AUGUST): 297-297.
Impact Factor: 4.609
View Export to BibTeX Export to EndNote
Alterio V, Langella E, De Simone G, Monti SM
* Cadmium-containing carbonic anhydrase CDCA1 in marine diatom Thalassiosira weissflogii (629 views)
Mar Drugs (ISSN: 1660-3397, 1660-3397linking), 2015 Mar 25; 13(4): 1688-1697.
Impact Factor: 3.345
View Export to BibTeX Export to EndNote
Merlo S, Basile L, Giuffrida ML, Sortino MA, Guccione S, Copani A
* Identification of 5-Methoxyflavone as a Novel DNA Polymerase-Beta Inhibitor and Neuroprotective Agent against Beta-Amyloid Toxicity (323 views)
J Nat Prod (ISSN: 0163-3864), 2015; 78(11): 2704-2711.
Impact Factor: 3.662
View Export to BibTeX Export to EndNote
Perri F, Pacelli R, Della Vittoria Scarpati G, Cella L, Giuliano M, Caponigro F, Pepe S
* Radioresistance in head and neck squamous cell carcinoma: Biological bases and therapeutic implications (522 views)
Head Neck-J Sci Spec (ISSN: 1043-3074), 2015; 37(5): 763-770.
Impact Factor: 2.76
View Export to BibTeX Export to EndNote
Correale S, de Paola I, Morgillo CM, Federico A, Zaccaro L, Pallante P, Galeone A, Fusco A, Pedone E, Luque FJ, Catalanotti B
* Structural Model of the hUbA1-UbcH10 Quaternary Complex: In Silico and Experimental Analysis of the Protein-Protein Interactions between E1, E2 and Ubiquitin (434 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2014 Nov 6; 9(11): e112082-e112082.
Impact Factor: 3.234
View Export to BibTeX Export to EndNote
Tornatore L, Sandomenico A, Raimondo D, Low C, Rocci A, Tralau-Stewart C, Capece D, D'Andrea D, Bua M, Boyle E, van Duin M, Zoppoli P, Jaxa-Chamiec A, Thotakura AK, Dyson J, Walker BA, Leonardi A, Chambery A, Driessen C, Sonneveld P, Morgan G, Palumbo A, Tramontano A, Rahemtulla A, Ruvo M, Franzoso G
* Cancer-selective targeting of the NF-kappaB survival pathway with GADD45beta/MKK7 inhibitors (623 views)
Cancer Cell (ISSN: 1535-6108), 2014 Oct 13; 26(4): 495-508.
Impact Factor: 23.523
View Export to BibTeX Export to EndNote
Oppermann S, Schrader FC, Elsasser K, Dolga AM, Kraus AL, Doti N, Wegscheid-Gerlach C, Schlitzer M, Culmsee C
* Novel N-Phenyl-Substituted Thiazolidinediones Protect Neural Cells against Glutamate- and tBid-Induced Toxicity (578 views)
J Pharmacol Exp Ther (ISSN: 0022-3565, 1521-0103), 2014 Sep; 350(2): 273-289.
Impact Factor: 3.972
View Export to BibTeX Export to EndNote
Doti N, Reuther C, Scognamiglio PL, Dolga AM, Plesnila N, Ruvo M, Culmsee C
* Inhibition of the AIF/CypA complex protects against intrinsic death pathways induced by oxidative stress (562 views)
Cell Death & (ISSN: 2041-4889, 2041-4889electronic), 2014 Jan 16; 5(1): e993-e993.
Impact Factor: 5.014
View Export to BibTeX Export to EndNote
Nande R, Greco A, Gossman MS, Lopez JP, Claudio L, Salvatore M, Brunetti A, Denvir J, Howard CM, Claudio PP
* Microbubble-assisted p53, RB, and p130 gene transfer in combination with radiation therapy in prostate cancer (457 views)
Current Gene Therapy (ISSN: 1875-5631, 1566-5232), 2013 Jun 1; 13(3): 163-174.
Impact Factor: 4.906
View Export to BibTeX Export to EndNote
Ruggiero A, De Simone P, Smaldone G, Squeglia F, Berisio R
* Bacterial cell division regulation by Ser/Thr kinases: A structural perspective (581 views)
Curr Protein Pept Sci (ISSN: 1389-2037, 1389-2037linking), 2012 Dec; 13(8): 756-766.
Impact Factor: 2.326
View Export to BibTeX Export to EndNote
Pascual B, Prieto E, Arbizu J, Marti-climent JM, Penuelas I, Quincoces G, Zarauza R, Pappata S, Masdeu JC
* Decreased carbon-11-flumazenil binding in early Alzheimer's disease (404 views) (PDF 259 views)
Brain (ISSN: 0006-8950, 1460-2156electronic, 0006-8950linking), 2012 Sep; 135(Pt9): 2817-2825.
Impact Factor: 9.915
View Export to BibTeX Export to EndNote
Volpe U, Mucci A, Quarantelli M, Galderisi S, Maj M
* Dorsolateral prefrontal cortex volume in patients with deficit or nondeficit schizophrenia (359 views) (PDF 208 views)
Prog Neuro Psychopharmacol Biol Psychiatry (ISSN: 0278-5846), 2012 Jun 1; 37(2): 264-269.
Impact Factor: 3.552
View Export to BibTeX Export to EndNote
Merolla F, Luise C, Muller MT, Pacelli R, Fusco A, Celetti A
* Loss of CCDC6, the First Identified RET Partner Gene, Affects pH2AX S139 Levels and Accelerates Mitotic Entry upon DNA Damage (361 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2012 May 24; 7(5): N/D-N/D.
Impact Factor: 3.73
View Export to BibTeX Export to EndNote
Zannetti A, Iommelli F, Speranza A, Salvatore M, Del Vecchio S
* 3'-deoxy-3'-18F-fluorothymidine (FLT) PET/CT to guide therapy with epidermal growth factor receptor (EGFR) antagonists and Bcl-xL inhibitors in non-small cell lung cancer (614 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 2012 Mar 1; 53(3): 443-450.
Impact Factor: 5.774
View Export to BibTeX Export to EndNote
Zannetti A, Iommelli F, Speranza A, Salvatore M, Del Vecchio S
* 3'-deoxy-3'-18F-fluorothymidine PET/CT to guide therapy with epidermal growth factor receptor antagonists and Bcl-xL inhibitors in non-small cell lung cancer (525 views)
J Nucl Med (ISSN: 1535-5667, 0161-5505, 1535-5667electronic), 2012 Mar 1; 53(3): 443-450.
Impact Factor: 5.774
View Export to BibTeX Export to EndNote
Calafiore M, Copani A, Deng W
* DNA polymerase-β mediates the neurogenic effect of β-amyloid protein in cultured subventricular zone neurospheres (596 views)
Journal Of Neuroscience Research (ISSN: 0360-4012), 2012 Mar; 90(3): 559-567.
Impact Factor: 2.974
View Export to BibTeX Export to EndNote
Caraci F, Spampinato S, Sortino MA, Bosco P, Battaglia G, Bruno V, Drago F, Nicoletti F, Copani A
* Dysfunction of TGF-β1 signaling in Alzheimer's disease: Perspectives for neuroprotection (957 views)
Cell Tissue Res (ISSN: 0302-766x), 2012 Jan; 347(1): 291-301.
Impact Factor: 3.677
View Export to BibTeX Export to EndNote
Palmieri D, Valentino T, D'Angelo D, De Martino I, Postiglione I, Pacelli R, Croce CM, Fedele M, Fusco A
* HMGA proteins promote ATM expression and enhance cancer cell resistance to genotoxic agents (856 views)
Oncogene (ISSN: 0950-9232, 1476-5594), 2011 Jul 7; 30(27): 3024-3035.
Impact Factor: 6.373
View Export to BibTeX Export to EndNote
Milite C, Castellano S, Benedetti R, Tosco A, Ciliberti C, Vicidomini C, Boully L, Franci G, Altucci L, Mai A, Sbardella G
* Modulation of the activity of histone acetyltransferases by long chain alkylidenemalonates (LoCAMs) (360 views)
Bioorg Med Chem (ISSN: 0968-0896, 1464-3391, 1464-3391electronic), 2011 Jun 15; 19(12): 3690-3701.
Impact Factor: 2.921
View Export to BibTeX Export to EndNote
Corona C, Frazzini V, Silvestri E, Lattanzio R, La Sorda R, Piantelli M, Canzoniero LM, Ciavardelli D, Rizzarelli E, Sensi SL
* Effects of dietary supplementation of carnosine on mitochondrial dysfunction, amyloid pathology, and cognitive deficits in 3xTg-AD mice (553 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2011 Mar 15; 6(3): e17971-e17971.
Impact Factor: 4.092
View Export to BibTeX Export to EndNote
Bellia F, Calabrese V, Guarino F, Cavallaro M, Cornelius C, De Pinto V, Rizzarelli E
* Carnosinase levels in aging brain: redox state induction and cellular stress response (415 views)
Antioxid Redox Signal (ISSN: 1557-7716, 1523-0864, 1523-0864linking), 2009 Nov; 11(11): 2759-2775.
Impact Factor: 7.581
View Export to BibTeX Export to EndNote
Farina AR, Tacconelli A, Cappabianca L, Cea G, Panella S, Chioda A, Romanelli A, Pedone C, Gulino A, Mackay AR
* The alternative TrkAIII splice variant targets the centrosome and promotes genetic instability (358 views)
Mol Cell Biol (ISSN: 1098-5549, 0270-7306), 2009 Sep 1; 29(17): 4812-4830.
Impact Factor: 6.057
View Export to BibTeX Export to EndNote
Caraci F, Busceti C, Biagioni F, Aronica E, Mastroiacovo F, Cappuccio I, Battaglia G, Bruno V, Caricasole A, Copani A, Nicoletti
* The Wnt antagonist, Dickkopf-1, as a target for the treatment of neurodegenerative disorders (384 views)
Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2008 Dec; 33(12): 2401-2406.
Impact Factor: 2.26
View Export to BibTeX Export to EndNote
Pentimalli F, Palmieri D, Pacelli R, Garbi C, Cesari R, Martin E, Pierantoni GM, Chieffi P, Croce CM, Costanzo V, Fedele M, Fusco A
* HMGA1 protein is a novel target of the ATM kinase (482 views)
European Journal Of Cancer (ISSN: 0959-8049), 2008 Nov; 44(17): 2668-2679.
Impact Factor: 4.475
View Export to BibTeX Export to EndNote
Castiglione M, Calafiore M, Costa L, Sortino MA, Nicoletti F, Copani A
* Group I metabotropic glutamate receptors control proliferation, survival and differentiation of cultured neural progenitor cells isolated from the subventricular zone of adult mice (424 views)
Neuropharm (ISSN: 0028-3908, 1873-7064electronic, 0028-3908linking), 2008 Sep; 55(4): 560-567.
Impact Factor: 3.383
View Export to BibTeX Export to EndNote
Sbardella G, Castellano S, Vicidomini C, Rotili D, Nebbioso A, Miceli M, Altucci L, Mai A
* Identification of long chain alkylidenemalonates as novel small molecule modulators of histone acetyltransferases (313 views)
Bioorganic & Medicinal Chemistry Letters (ISSN: 0960-894x), 2008 May 1; 18(9): 2788-2792.
Impact Factor: 2.531
View Export to BibTeX Export to EndNote
Jovanovic H, Lundberg J, Karlsson P, Cerin A, Saijo T, Varrone A, Halldin C, Nordstrom AL
* Sex differences in the serotonin 1A receptor and serotonin transporter binding in the human brain measured by PET (493 views)
Neuroimage (ISSN: 1053-8119, 1053-8119linking), 2008 Feb 1; 39(3): 1408-1419.
Impact Factor: 5.694
View Export to BibTeX Export to EndNote
Copani A, Guccione S, Giurato L, Caraci F, Calafiore M, Sortino MA
* The cell cycle molecules behind neurodegeneration in Alzheimer's disease: Perspectives for drug development (452 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2008; 15(24): 2420-2432.
Impact Factor: 4.823
View Export to BibTeX Export to EndNote
Merolla F, Pentimalli F, Pacelli R, Vecchio G, Fusco A, Grieco M, Celetti A
* Involvement of H4(D10S170) protein in ATM-dependent response to DNA damage (606 views)
Oncogene (ISSN: 0950-9232, 1476-5594), 2007 Sep 13; 26(42): 6167-6175.
Impact Factor: 6.44
View Export to BibTeX Export to EndNote
Copani A, Caraci F, Hoozemans J, Calafiore M, Sortino M, Nicoletti F
* The nature of the cell cycle in neurons: Focus on a "non-canonical" pathway of DNA replication causally related to death (481 views)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2007 Apr; 1772(4): 409-412.
Impact Factor: 3.078
View Export to BibTeX Export to EndNote
Bosco P, Caraci F, Copani A, Spada R, Sortino M, Salluzzo R, Salemi M, Nicoletti F, Ferri R
* The CDC2 I-G-T haplotype associated with the APOE ε4 allele increases the risk of sporadic Alzheimer's disease in Sicily (372 views)
Neurosci Lett (ISSN: 0304-3940), 2007; 419(3): 195-198.
Impact Factor: 2.085
View Export to BibTeX Export to EndNote
Mai A, Rotili D, Tarantino D, Ornaghi P, Tosi F, Vicidomini C, Sbardella G, Nebbioso A, Miceli M, Altucci L, Filetici P
* Small-molecule inhibitors of histone acetyltransferase activity: Identification and biological properties (508 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2006 Nov 16; 49(23): 6897-6907.
Impact Factor: 5.115
View Export to BibTeX Export to EndNote
Berkouk K, Quarantelli M, Prinster A, Landeau B, Alfano B, Baron JC
* Mapping The Relative Contribution Of Gray Matter Activity Versus Volume In Brain Pet. A New Approach (388 views) (PDF 231 views)
J Neuroimaging (ISSN: 1051-2284, 1051-2284linking), 2006 Jul; 16(3): 224-235.
Impact Factor: 1.298
View Export to BibTeX Export to EndNote
Di Pietro C, Piro S, Tabbì G, Ragusa M, Di Pietro V, Zimmitti V, Cuda F, Anello M, Consoli U, Salinaro ET, Caruso M, Vancheri C, Crimi N, Sabini MG, Cirrone GA, Raffaele L, Privitera G, Pulvirenti A, Giugno R, Ferro A, Cuttone G, Lo Nigro S, Purrello R, Purrello F, Purrello M
* Cellular and molecular effects of protons: Apoptosis induction and potential implications for cancer therapy (520 views)
Apoptosis (ISSN: 1360-8185), 2006 Jan; 11(1): 57-66.
Impact Factor: 3.421
View Export to BibTeX Export to EndNote
Copani A, Hoozemans JJM, Caraci F, Calafiore M, Van Haastert ES, Veerhuis R, Rozemuller AJM, Aronica E, Sortino MA, Nicoletti F
* Dna Polymerase-Beta Is Expressed Early In Neurons Of Alzheimer'S Disease Brain And Is Loaded Into Dna Replication Forks In Neurons Challenged With Beta-Amyloid (491 views)
J Neurosci (ISSN: 0270-6474, 0361-803x, 1529-2401), 2006; 26(43): 10949-10957.
Impact Factor: 2.117
View Export to BibTeX Export to EndNote
Herscher LL, Cook JA, Pacelli R, Pass HI, Russo A, Mitchell JB
Principles of chemoradiation: Theoretical and practical considerations (406 views)
Oncology (ISSN: 0890-9091), 1999 Oct; 13(10SUPPL.5): 11-22.
Impact Factor: 0.933
View Export to BibTeX Export to EndNote
Dringenberg HC, Kornelsen RA, Pacelli R, Petersen K, Vanderwolf CH
Effects of amygdaloid lesions, hippocampal lesions, and buspirone on black-white exploration and food carrying in rats (263 views)
Behav Brain Res (ISSN: 0166-4328), 1998 Nov; 96(1-2): 161-172.
Impact Factor: 2.796
View Export to BibTeX Export to EndNote
Cook JA, Krishna MC, Pacelli R, DeGraff W, Liebmann J, Mitchell JB, Russo A, Wink DA
Nitric oxide enhancement of melphalan-induced cytotoxicity (486 views)
Br J Cancer (ISSN: 0007-0920, 0007-0920print, 0007-0920linking), 1997 Sep; 76(3): 325-334.
Impact Factor: 2.938
View Export to BibTeX Export to EndNote
Scala S, Pacelli R, Iaffaioli RV, Normanno N, Pepe S, Frasci G, Genua G, Tsuruo T, Tagliaferri P, Bianco AR
Reversal of adriamycin resistance by recombinant α-interferon in multidrug-resistant human colon carcinoma LoVo-doxorubicin cells (559 views)
Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 1991 Sep 15; 51(18): 4898-4902.
Impact Factor: 8.426
View Export to BibTeX Export to EndNote
* Proteomics-Based Evidence for a Pro-Oncogenic Role of ESRP1 in Human Colorectal Cancer Cells (128 views)
Int J Mol Sc (ISSN: 1422-0067linking, 1661-6596, 1422-0067electronic), 2020 Jan 16; 21 (2 ): N/D-N/D.
Impact Factor: 2.598
View Export to BibTeX Export to EndNote
Miceli M, Cutignano A, Conte M, Ummarino R, Romanelli A, Ruvo M, Leone M, Mercurio FA, Doti N, Manzo E, Romano G, Altucci L, Ianora A
* Monoacylglycerides from the Diatom Skeletonema marinoi Induce Selective Cell Death in Cancer Cells (158 views)
Mar Drugs (ISSN: 1660-3397linking), 2019 Nov 1; 17 (11 ): N/D-N/D.
Impact Factor: 3.345
View Export to BibTeX Export to EndNote
Carella A, Roviello V, Iannitti R, Palumbo R, La Manna S, Marasco D, Trifuoggi M, Diana R, Roviello GN
* Evaluating the biological properties of synthetic 4-nitrophenyl functionalized benzofuran derivatives with telomeric DNA binding and antiproliferative activities (397 views)
Int J Biol Macromol (ISSN: 0141-8130linking, 1879-0003electronic), 2019 Jan; 121: 77-88.
Impact Factor: 4.784
View Export to BibTeX Export to EndNote
Petraglia F, Singh AA, Carafa V, Nebbioso A, Conte M, Scisciola L, Valente S, Baldi A, Mandoli A, Petrizzi VB, Ingenito C, De Falco S, Cicatiello V, Apicella I, Janssen-megens EM, Kim B, Yi G, Logie C, Heath S, Ruvo M, Wierenga ATJ, Flicek P, Yaspo ML, Della Valle V, Bernard O, Tomassi S, Novellino E, Feoli A, Sbardella G, Gut I, Vellenga E, Stunnenberg HG, Mai A, Martens JHA, Altucci L
* Combined HAT/EZH2 modulation leads to cancer-selective cell death (284 views)
Oncotarget (ISSN: 1949-2553electronic, 1949-2553linking), 2018 May 22; 9(39): 25630-25646.
Impact Factor: 5.008
View Export to BibTeX Export to EndNote
Di Menna L, Joffe ME, Iacovelli L, Orlando R, Lindsley CW, Mairesse J, Gressèns P, Cannella M, Caraci F, Copani A, Bruno V, Battaglia G, Conn PJ, Nicoletti F
* Functional partnership between mGlu3 and mGlu5 metabotropic glutamate receptors in the central nervous system (395 views)
Neuropharm (ISSN: 0028-3908linking, 1873-7064electronic), 2018 Jan; 128: 301-313.
Impact Factor: 3.383
View Export to BibTeX Export to EndNote
Leggio GM, Catania MV, Puzzo D, Spatuzza M, Pellitteri R, Gulisano W, Torrisi SA, Giurdanella G, Piazza C, Impellizzeri AR, Gozzo L, Navarria A, Bucolo C, Nicoletti F, Palmeri A, Salomone S, Copani A, Caraci F, Drago F
* The antineoplastic drug flavopiridol reverses memory impairment induced by Amyloid-ss1-42 oligomers in mice (466 views)
Pharmacol Res (ISSN: 1043-6618, 1096-1186electronic), 2016 Apr; 106: 10-20.
Impact Factor: 4.48
View Export to BibTeX Export to EndNote
Giuffrida ML, Tomasello MF, Pandini G, Caraci F, Battaglia G, Busceti C, Di Pietro P, Pappalardo G, Attanasio F, Chiechio S, Bagnoli S, Nacmias B, Sorbi S, Vigneri R, Rizzarelli E, Nicoletti F, Copani A
* Monomeric ss-amyloid interacts with type-1 insulin-like growth factor receptors to provide energy supply to neurons (526 views)
Front Cell Neurosci (ISSN: 1662-5102), 2015 Aug 7; 9(AUGUST): 297-297.
Impact Factor: 4.609
View Export to BibTeX Export to EndNote
Alterio V, Langella E, De Simone G, Monti SM
* Cadmium-containing carbonic anhydrase CDCA1 in marine diatom Thalassiosira weissflogii (629 views)
Mar Drugs (ISSN: 1660-3397, 1660-3397linking), 2015 Mar 25; 13(4): 1688-1697.
Impact Factor: 3.345
View Export to BibTeX Export to EndNote
Merlo S, Basile L, Giuffrida ML, Sortino MA, Guccione S, Copani A
* Identification of 5-Methoxyflavone as a Novel DNA Polymerase-Beta Inhibitor and Neuroprotective Agent against Beta-Amyloid Toxicity (323 views)
J Nat Prod (ISSN: 0163-3864), 2015; 78(11): 2704-2711.
Impact Factor: 3.662
View Export to BibTeX Export to EndNote
Perri F, Pacelli R, Della Vittoria Scarpati G, Cella L, Giuliano M, Caponigro F, Pepe S
* Radioresistance in head and neck squamous cell carcinoma: Biological bases and therapeutic implications (522 views)
Head Neck-J Sci Spec (ISSN: 1043-3074), 2015; 37(5): 763-770.
Impact Factor: 2.76
View Export to BibTeX Export to EndNote
Correale S, de Paola I, Morgillo CM, Federico A, Zaccaro L, Pallante P, Galeone A, Fusco A, Pedone E, Luque FJ, Catalanotti B
* Structural Model of the hUbA1-UbcH10 Quaternary Complex: In Silico and Experimental Analysis of the Protein-Protein Interactions between E1, E2 and Ubiquitin (434 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2014 Nov 6; 9(11): e112082-e112082.
Impact Factor: 3.234
View Export to BibTeX Export to EndNote
Tornatore L, Sandomenico A, Raimondo D, Low C, Rocci A, Tralau-Stewart C, Capece D, D'Andrea D, Bua M, Boyle E, van Duin M, Zoppoli P, Jaxa-Chamiec A, Thotakura AK, Dyson J, Walker BA, Leonardi A, Chambery A, Driessen C, Sonneveld P, Morgan G, Palumbo A, Tramontano A, Rahemtulla A, Ruvo M, Franzoso G
* Cancer-selective targeting of the NF-kappaB survival pathway with GADD45beta/MKK7 inhibitors (623 views)
Cancer Cell (ISSN: 1535-6108), 2014 Oct 13; 26(4): 495-508.
Impact Factor: 23.523
View Export to BibTeX Export to EndNote
Oppermann S, Schrader FC, Elsasser K, Dolga AM, Kraus AL, Doti N, Wegscheid-Gerlach C, Schlitzer M, Culmsee C
* Novel N-Phenyl-Substituted Thiazolidinediones Protect Neural Cells against Glutamate- and tBid-Induced Toxicity (578 views)
J Pharmacol Exp Ther (ISSN: 0022-3565, 1521-0103), 2014 Sep; 350(2): 273-289.
Impact Factor: 3.972
View Export to BibTeX Export to EndNote
Doti N, Reuther C, Scognamiglio PL, Dolga AM, Plesnila N, Ruvo M, Culmsee C
* Inhibition of the AIF/CypA complex protects against intrinsic death pathways induced by oxidative stress (562 views)
Cell Death & (ISSN: 2041-4889, 2041-4889electronic), 2014 Jan 16; 5(1): e993-e993.
Impact Factor: 5.014
View Export to BibTeX Export to EndNote
Nande R, Greco A, Gossman MS, Lopez JP, Claudio L, Salvatore M, Brunetti A, Denvir J, Howard CM, Claudio PP
* Microbubble-assisted p53, RB, and p130 gene transfer in combination with radiation therapy in prostate cancer (457 views)
Current Gene Therapy (ISSN: 1875-5631, 1566-5232), 2013 Jun 1; 13(3): 163-174.
Impact Factor: 4.906
View Export to BibTeX Export to EndNote
Ruggiero A, De Simone P, Smaldone G, Squeglia F, Berisio R
* Bacterial cell division regulation by Ser/Thr kinases: A structural perspective (581 views)
Curr Protein Pept Sci (ISSN: 1389-2037, 1389-2037linking), 2012 Dec; 13(8): 756-766.
Impact Factor: 2.326
View Export to BibTeX Export to EndNote
Pascual B, Prieto E, Arbizu J, Marti-climent JM, Penuelas I, Quincoces G, Zarauza R, Pappata S, Masdeu JC
* Decreased carbon-11-flumazenil binding in early Alzheimer's disease (404 views) (PDF 259 views)
Brain (ISSN: 0006-8950, 1460-2156electronic, 0006-8950linking), 2012 Sep; 135(Pt9): 2817-2825.
Impact Factor: 9.915
View Export to BibTeX Export to EndNote
Volpe U, Mucci A, Quarantelli M, Galderisi S, Maj M
* Dorsolateral prefrontal cortex volume in patients with deficit or nondeficit schizophrenia (359 views) (PDF 208 views)
Prog Neuro Psychopharmacol Biol Psychiatry (ISSN: 0278-5846), 2012 Jun 1; 37(2): 264-269.
Impact Factor: 3.552
View Export to BibTeX Export to EndNote
Merolla F, Luise C, Muller MT, Pacelli R, Fusco A, Celetti A
* Loss of CCDC6, the First Identified RET Partner Gene, Affects pH2AX S139 Levels and Accelerates Mitotic Entry upon DNA Damage (361 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2012 May 24; 7(5): N/D-N/D.
Impact Factor: 3.73
View Export to BibTeX Export to EndNote
Zannetti A, Iommelli F, Speranza A, Salvatore M, Del Vecchio S
* 3'-deoxy-3'-18F-fluorothymidine (FLT) PET/CT to guide therapy with epidermal growth factor receptor (EGFR) antagonists and Bcl-xL inhibitors in non-small cell lung cancer (614 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 2012 Mar 1; 53(3): 443-450.
Impact Factor: 5.774
View Export to BibTeX Export to EndNote
Zannetti A, Iommelli F, Speranza A, Salvatore M, Del Vecchio S
* 3'-deoxy-3'-18F-fluorothymidine PET/CT to guide therapy with epidermal growth factor receptor antagonists and Bcl-xL inhibitors in non-small cell lung cancer (525 views)
J Nucl Med (ISSN: 1535-5667, 0161-5505, 1535-5667electronic), 2012 Mar 1; 53(3): 443-450.
Impact Factor: 5.774
View Export to BibTeX Export to EndNote
Calafiore M, Copani A, Deng W
* DNA polymerase-β mediates the neurogenic effect of β-amyloid protein in cultured subventricular zone neurospheres (596 views)
Journal Of Neuroscience Research (ISSN: 0360-4012), 2012 Mar; 90(3): 559-567.
Impact Factor: 2.974
View Export to BibTeX Export to EndNote
Caraci F, Spampinato S, Sortino MA, Bosco P, Battaglia G, Bruno V, Drago F, Nicoletti F, Copani A
* Dysfunction of TGF-β1 signaling in Alzheimer's disease: Perspectives for neuroprotection (957 views)
Cell Tissue Res (ISSN: 0302-766x), 2012 Jan; 347(1): 291-301.
Impact Factor: 3.677
View Export to BibTeX Export to EndNote
Palmieri D, Valentino T, D'Angelo D, De Martino I, Postiglione I, Pacelli R, Croce CM, Fedele M, Fusco A
* HMGA proteins promote ATM expression and enhance cancer cell resistance to genotoxic agents (856 views)
Oncogene (ISSN: 0950-9232, 1476-5594), 2011 Jul 7; 30(27): 3024-3035.
Impact Factor: 6.373
View Export to BibTeX Export to EndNote
Milite C, Castellano S, Benedetti R, Tosco A, Ciliberti C, Vicidomini C, Boully L, Franci G, Altucci L, Mai A, Sbardella G
* Modulation of the activity of histone acetyltransferases by long chain alkylidenemalonates (LoCAMs) (360 views)
Bioorg Med Chem (ISSN: 0968-0896, 1464-3391, 1464-3391electronic), 2011 Jun 15; 19(12): 3690-3701.
Impact Factor: 2.921
View Export to BibTeX Export to EndNote
Corona C, Frazzini V, Silvestri E, Lattanzio R, La Sorda R, Piantelli M, Canzoniero LM, Ciavardelli D, Rizzarelli E, Sensi SL
* Effects of dietary supplementation of carnosine on mitochondrial dysfunction, amyloid pathology, and cognitive deficits in 3xTg-AD mice (553 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2011 Mar 15; 6(3): e17971-e17971.
Impact Factor: 4.092
View Export to BibTeX Export to EndNote
Bellia F, Calabrese V, Guarino F, Cavallaro M, Cornelius C, De Pinto V, Rizzarelli E
* Carnosinase levels in aging brain: redox state induction and cellular stress response (415 views)
Antioxid Redox Signal (ISSN: 1557-7716, 1523-0864, 1523-0864linking), 2009 Nov; 11(11): 2759-2775.
Impact Factor: 7.581
View Export to BibTeX Export to EndNote
Farina AR, Tacconelli A, Cappabianca L, Cea G, Panella S, Chioda A, Romanelli A, Pedone C, Gulino A, Mackay AR
* The alternative TrkAIII splice variant targets the centrosome and promotes genetic instability (358 views)
Mol Cell Biol (ISSN: 1098-5549, 0270-7306), 2009 Sep 1; 29(17): 4812-4830.
Impact Factor: 6.057
View Export to BibTeX Export to EndNote
Caraci F, Busceti C, Biagioni F, Aronica E, Mastroiacovo F, Cappuccio I, Battaglia G, Bruno V, Caricasole A, Copani A, Nicoletti
* The Wnt antagonist, Dickkopf-1, as a target for the treatment of neurodegenerative disorders (384 views)
Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2008 Dec; 33(12): 2401-2406.
Impact Factor: 2.26
View Export to BibTeX Export to EndNote
Pentimalli F, Palmieri D, Pacelli R, Garbi C, Cesari R, Martin E, Pierantoni GM, Chieffi P, Croce CM, Costanzo V, Fedele M, Fusco A
* HMGA1 protein is a novel target of the ATM kinase (482 views)
European Journal Of Cancer (ISSN: 0959-8049), 2008 Nov; 44(17): 2668-2679.
Impact Factor: 4.475
View Export to BibTeX Export to EndNote
Castiglione M, Calafiore M, Costa L, Sortino MA, Nicoletti F, Copani A
* Group I metabotropic glutamate receptors control proliferation, survival and differentiation of cultured neural progenitor cells isolated from the subventricular zone of adult mice (424 views)
Neuropharm (ISSN: 0028-3908, 1873-7064electronic, 0028-3908linking), 2008 Sep; 55(4): 560-567.
Impact Factor: 3.383
View Export to BibTeX Export to EndNote
Sbardella G, Castellano S, Vicidomini C, Rotili D, Nebbioso A, Miceli M, Altucci L, Mai A
* Identification of long chain alkylidenemalonates as novel small molecule modulators of histone acetyltransferases (313 views)
Bioorganic & Medicinal Chemistry Letters (ISSN: 0960-894x), 2008 May 1; 18(9): 2788-2792.
Impact Factor: 2.531
View Export to BibTeX Export to EndNote
Jovanovic H, Lundberg J, Karlsson P, Cerin A, Saijo T, Varrone A, Halldin C, Nordstrom AL
* Sex differences in the serotonin 1A receptor and serotonin transporter binding in the human brain measured by PET (493 views)
Neuroimage (ISSN: 1053-8119, 1053-8119linking), 2008 Feb 1; 39(3): 1408-1419.
Impact Factor: 5.694
View Export to BibTeX Export to EndNote
Copani A, Guccione S, Giurato L, Caraci F, Calafiore M, Sortino MA
* The cell cycle molecules behind neurodegeneration in Alzheimer's disease: Perspectives for drug development (452 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2008; 15(24): 2420-2432.
Impact Factor: 4.823
View Export to BibTeX Export to EndNote
Merolla F, Pentimalli F, Pacelli R, Vecchio G, Fusco A, Grieco M, Celetti A
* Involvement of H4(D10S170) protein in ATM-dependent response to DNA damage (606 views)
Oncogene (ISSN: 0950-9232, 1476-5594), 2007 Sep 13; 26(42): 6167-6175.
Impact Factor: 6.44
View Export to BibTeX Export to EndNote
Copani A, Caraci F, Hoozemans J, Calafiore M, Sortino M, Nicoletti F
* The nature of the cell cycle in neurons: Focus on a "non-canonical" pathway of DNA replication causally related to death (481 views)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2007 Apr; 1772(4): 409-412.
Impact Factor: 3.078
View Export to BibTeX Export to EndNote
Bosco P, Caraci F, Copani A, Spada R, Sortino M, Salluzzo R, Salemi M, Nicoletti F, Ferri R
* The CDC2 I-G-T haplotype associated with the APOE ε4 allele increases the risk of sporadic Alzheimer's disease in Sicily (372 views)
Neurosci Lett (ISSN: 0304-3940), 2007; 419(3): 195-198.
Impact Factor: 2.085
View Export to BibTeX Export to EndNote
Mai A, Rotili D, Tarantino D, Ornaghi P, Tosi F, Vicidomini C, Sbardella G, Nebbioso A, Miceli M, Altucci L, Filetici P
* Small-molecule inhibitors of histone acetyltransferase activity: Identification and biological properties (508 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2006 Nov 16; 49(23): 6897-6907.
Impact Factor: 5.115
View Export to BibTeX Export to EndNote
Berkouk K, Quarantelli M, Prinster A, Landeau B, Alfano B, Baron JC
* Mapping The Relative Contribution Of Gray Matter Activity Versus Volume In Brain Pet. A New Approach (388 views) (PDF 231 views)
J Neuroimaging (ISSN: 1051-2284, 1051-2284linking), 2006 Jul; 16(3): 224-235.
Impact Factor: 1.298
View Export to BibTeX Export to EndNote
Di Pietro C, Piro S, Tabbì G, Ragusa M, Di Pietro V, Zimmitti V, Cuda F, Anello M, Consoli U, Salinaro ET, Caruso M, Vancheri C, Crimi N, Sabini MG, Cirrone GA, Raffaele L, Privitera G, Pulvirenti A, Giugno R, Ferro A, Cuttone G, Lo Nigro S, Purrello R, Purrello F, Purrello M
* Cellular and molecular effects of protons: Apoptosis induction and potential implications for cancer therapy (520 views)
Apoptosis (ISSN: 1360-8185), 2006 Jan; 11(1): 57-66.
Impact Factor: 3.421
View Export to BibTeX Export to EndNote
Copani A, Hoozemans JJM, Caraci F, Calafiore M, Van Haastert ES, Veerhuis R, Rozemuller AJM, Aronica E, Sortino MA, Nicoletti F
* Dna Polymerase-Beta Is Expressed Early In Neurons Of Alzheimer'S Disease Brain And Is Loaded Into Dna Replication Forks In Neurons Challenged With Beta-Amyloid (491 views)
J Neurosci (ISSN: 0270-6474, 0361-803x, 1529-2401), 2006; 26(43): 10949-10957.
Impact Factor: 2.117
View Export to BibTeX Export to EndNote
Herscher LL, Cook JA, Pacelli R, Pass HI, Russo A, Mitchell JB
Principles of chemoradiation: Theoretical and practical considerations (406 views)
Oncology (ISSN: 0890-9091), 1999 Oct; 13(10SUPPL.5): 11-22.
Impact Factor: 0.933
View Export to BibTeX Export to EndNote
Dringenberg HC, Kornelsen RA, Pacelli R, Petersen K, Vanderwolf CH
Effects of amygdaloid lesions, hippocampal lesions, and buspirone on black-white exploration and food carrying in rats (263 views)
Behav Brain Res (ISSN: 0166-4328), 1998 Nov; 96(1-2): 161-172.
Impact Factor: 2.796
View Export to BibTeX Export to EndNote
Cook JA, Krishna MC, Pacelli R, DeGraff W, Liebmann J, Mitchell JB, Russo A, Wink DA
Nitric oxide enhancement of melphalan-induced cytotoxicity (486 views)
Br J Cancer (ISSN: 0007-0920, 0007-0920print, 0007-0920linking), 1997 Sep; 76(3): 325-334.
Impact Factor: 2.938
View Export to BibTeX Export to EndNote
Scala S, Pacelli R, Iaffaioli RV, Normanno N, Pepe S, Frasci G, Genua G, Tsuruo T, Tagliaferri P, Bianco AR
Reversal of adriamycin resistance by recombinant α-interferon in multidrug-resistant human colon carcinoma LoVo-doxorubicin cells (559 views)
Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 1991 Sep 15; 51(18): 4898-4902.
Impact Factor: 8.426
View Export to BibTeX Export to EndNote
45 Records (41 excluding Abstracts).
Total impact factor: 205.182 (189.112 excluding Abstracts).
Total 5 year impact factor: 220.434 (202.66 excluding Abstracts).
Total impact factor: 205.182 (189.112 excluding Abstracts).
Total 5 year impact factor: 220.434 (202.66 excluding Abstracts).
363 views. Last view on Wednesday 01 February 2023, 5:38:45
ibb.cnr.it
