The Wnt antagonist, Dickkopf-1, as a target for the treatment of neurodegenerative disorders(388 views) Caraci F, Busceti C, Biagioni F, Aronica E, Mastroiacovo F, Cappuccio I, Battaglia G, Bruno V, Caricasole A, Copani A, Nicoletti
Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2008 Dec; 33(12): 2401-2406.
Department of Pharmaceutical Sciences, University of Catania, Viale Andrea Doria 6, 95125 Catania, Italy
I.N.M. Neuromed, Località Camerelle, 86077 Pozzilli, Italy
Department of Neuropathology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands
Department of Human Physiology and Pharmacology, University of Rome La Sapienza, 00185 Rome, Italy
Siena Biotech, Siena, Italy
I.B.B., CNR-Catania, 95125 Catania, Italy
I. N. M. Neuromed, Localit Camerelle, 86077 Pozzilli, Italy
I. B. B., CNR-Catania, 95125 Catania, Italy
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Krupnik, V. E., Sharp, J. D., Jiang, C., Functional and structural diversity of the human Dickkopf gene family (1999) Gene, 238, pp. 301-313
Brott, B. K., Sokol, S. Y., Regulation of Wnt/LRP signalling by distinct domains of Dickkopf proteins (2002) Mol Cell Biol, 22, pp. 6100-6110
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Jope, R. S., Lithium and GSK-3: One inhibitor, two inhibitory actions, multiple outcomes (2003) Trends Pharmacol Sci, 24, pp. 441-443
Kang, D. E., Soriano, S., Xia, X., Presenilin couples the paired phosphorylation of beta-catenin independent of axin: Implications for beta-catenin activation in tumorigenesis (2002) Cell, 110, pp. 751-762
De Ferrari, G. V., Moon, R. T., The ups and downs of Wnt signaling in prevalent neurological disorders (2006) Oncogene, 25, pp. 7545-7553
Busceti, C. L., Biagioni, F., Aronica, E., Induction of the Wnt inhibitor, Dickkopf-1, is associated with neurodegeneration related to temporal lobe epilepsy (2007) Epilepsia, 48, pp. 694-705
Zakzanis, K. K., Campbell, Z., Memory impairment in now abstinent MDMA users and continued users: A longitudinal follow-up (2006) Neurology, 66, pp. 740-741
Huang, H. C., Klein, P. S., Multiple roles for glycogen synthase kinase-3 as a drug target in Alzheimer's disease (2006) Curr Drug Targets, 7, pp. 1389-1397
Nunes, P. V., Forlenza, O. V., Gattaz, W. F., Lithium and risk for Alzheimer's disease in elderly patients with bipolar disorder (2007) Br J Psychiatry, 190, pp. 359-360
The Wnt antagonist, Dickkopf-1, as a target for the treatment of neurodegenerative disorders