The Wnt antagonist, Dickkopf-1, as a target for the treatment of neurodegenerative disorders (388 views)
Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2008 Dec; 33(12): 2401-2406.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 2.26, 5-year impact factor: 2.312
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-56349085908&partnerID=40&md5=a97e5a234e50a5bcab001baa23560cee
Keywords: β-Catenin, Canonical Wnt Pathway, Dkk-1, Lithium, Neurodegeneration, Neuronal Death, Amyloid Beta Protein, Dickkopf 1 Antagonist, Dickkopf 1 Protein, Kainic Acid, N Methyl Dextro Aspartic Acid, Unclassified Drug, Wnt Antagonist, Wnt Protein, Degenerative Disease, Excitotoxicity, Human, Nonhuman, Pathophysiology, Priority Journal, Protein Expression, Review, Temporal Lobe Epilepsy, Intercellular Signaling Peptides And Proteins, Neurodegenerative Diseases, Animalia,
Affiliations:
*** IBB - CNR ***
Department of Pharmaceutical Sciences, University of Catania, Viale Andrea Doria 6, 95125 Catania, Italy
I.N.M. Neuromed, Località Camerelle, 86077 Pozzilli, Italy
Department of Neuropathology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands
Department of Human Physiology and Pharmacology, University of Rome La Sapienza, 00185 Rome, Italy
Siena Biotech, Siena, Italy
I.B.B., CNR-Catania, 95125 Catania, Italy
I. N. M. Neuromed, Localit Camerelle, 86077 Pozzilli, Italy
I. B. B., CNR-Catania, 95125 Catania, Italy
References:
Dale, T.C., Signal transduction by the Wnt family of ligands (1998) Biochem J, 329, pp. 209-22
He, X., Semenov, M., Tamai, K., LDL receptor-related proteins 5 and 6 in Wnt/beta-catenin signaling: Arrows point the way (2004) Development, 131, pp. 1663-1677
Miller, J.R., Hocking, A.M., Brown, J.D., Mechanism and function of signal transduction by the Wnt/beta-catenin and Wnt/Ca2+ pathways (1999) Oncogene, 18, pp. 7860-7872
Prunier, C., Hocevar, B.A., Howe, P.H., Wnt signaling: Physiology and pathology (2004) Growth Factors, 22, pp. 141-150
Miller, J.R., The Wnts (2002) Genome Biol, 3, pp. 30011-300115. , 1
Moon, R.T., Bowerman, B., Boutros, M., The promise and perils of Wnt signaling through β-catenin (2002) Science, 296, pp. 1644-1646
Mlodzik, M., Planar cell polarization: Do the same mechanisms regulate Drosophila tissue polarity and vertebrate gastrulation? (2002) Trends Genet, 18, pp. 564-571
Kühl, M., Sheldahl, L.C., Park, M., The Wnt/Ca2+pathway: A new vertebrate Wnt signaling pathway takes shape (2000) Trends Genet, 16, pp. 279-283
Tamai, K., Semenov, M., Kato, Y., LDL-receptor-related proteins in Wnt signal transduction (2000) Nature, 407, pp. 530-535
Wehrli, M., Dougan, S.T., Caldwell, K., Arrow encodes an LDL-receptor-related protein essential for Wingless signalling (2000) Nature, 407, pp. 527-530
Liu, C., Li, Y., Semenov, M., Control of β-catenin phosphorylation/degradation by a dual-kinase mechanism (2002) Cell, 108, pp. 837-847
Aberle, H., Bauer, A., Stappert, J., Beta-catenin is a target for the ubiquitin-proteasome pathway (1997) EMBO J, 16, pp. 3797-3804
Willert, K., Nusse, R., Beta-catenin: A key mediator of Wnt signaling (1998) Curr Opin Genet Dev, 8, pp. 95-102
Willert, K., Jones, K.A., Wnt signaling: Is the party in the nucleus? (2006) Genes Dev, 20, pp. 1394-1404
Salinas, P.C., Wnt factors in axonal remodelling and synaptogenesis (1999) Biochem Soc Symp, 65, pp. 101-109
Yu, X., Malenka, R.C., Beta-catenin is critical for dendritic morphogenesis (2003) Nat Neurosci, 6, pp. 1169-1177
Murase, S., Mosser, E., Schuman, E.M., Depolarization drives beta-catenin into neuronal spines promoting changes in synaptic structure and function (2002) Neuron, 35, pp. 91-105
Niehrs, C., Function and biological roles of the Dickkopf family of Wnt modulators (2006) Oncogene, 25, pp. 7469-7481
Krupnik, V.E., Sharp, J.D., Jiang, C., Functional and structural diversity of the human Dickkopf gene family (1999) Gene, 238, pp. 301-313
Brott, B.K., Sokol, S.Y., Regulation of Wnt/LRP signalling by distinct domains of Dickkopf proteins (2002) Mol Cell Biol, 22, pp. 6100-6110
Diep, D.B., Hoen, N., Backman, M., Characterisation of the Wnt antagonists and their response to conditionally activated Wnt signalling in the developing mouse forebrain (2004) Brain Res Dev Brain Res, 153, pp. 261-270
Grotewold, L., Ruther, U., The Wnt antagonist Dickkopf-1 is 675 regulated by Bmp signaling and c-Jun and modulates programmed cell death (2002) EMBO J, 21, pp. 966-975
Glinka, A., Wu, W., Delius, H., Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction (1998) Nature, 391, pp. 357-362
Zorn, A.M., Wnt signalling: Antagonistic Dickkopfs (2001) Curr Biol, 11, pp. 592-R595
Mao, B., Niehrs, C., Kremen2 modulates Dickkopf2 activity during Wnt/LRP6 signaling (2003) Gene, 302, pp. 179-183
Wang, J., Shou, J., Chen, X., Dickkopf-1, an inhibitor of the Wnt signaling pathway, is induced by p53 (2000) Oncogene, 19, pp. 1843-1848
Slee, E.A., O'Connor, D.J., Lu, X., To die or not to die: How does p53 decide? (2004) Oncogene, 23, pp. 2809-2818
Choi, D.W., Calcium and excitotoxic neuronal injury (1994) Ann N Y Acad Sci, 747, pp. 162-171
Zipfel, G.J., Babcock, D.J., Lee, J.M., Neuronal apoptosis after CNS injury: The roles of glutamate and calcium (2000) J Neurotrauma, 17, pp. 857-869
Bruno, V., Battaglia, G., Copani, A., Metabotropic glutamate receptor subtypes as targets for neuroprotective drugs (2001) J Cereb Blood Flow Metab, 21, pp. 1013-1033
Cappuccio, I., Calderone, A., Busceti, C.L., Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is required for the development of ischemic neuronal death (2005) J Neurosci, 25, pp. 2647-2657
Jope, R.S., Lithium and GSK-3: One inhibitor, two inhibitory actions, multiple outcomes (2003) Trends Pharmacol Sci, 24, pp. 441-443
Scali, C., Caraci, F., Gianfriddo, M., Inhibition of Wnt signaling, modulation of Tau phosphorylation and induction of neuronal cell death by DKK1 (2006) Neurobiol Dis, 24, pp. 254-265
Oddo, S., Caccamo, A., Kitazawa, M., Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease (2003) Neurobiol Aging, 24, pp. 1063-1070
Blurton-Jones, M., Laferla, F.M., Pathways by which Abeta facilitates tau pathology (2006) Curr Alzheimer Res, 3, pp. 437-448
Takashima, A., Honda, T., Yasutake, K., Activation of tau protein kinase I/glycogen synthase kinase-3beta by amyloid beta peptide (25-35) enhances phosphorylation of tau in hippocampal neurons (1998) J Neurosci Res, 31, pp. 317-323
Takashima, A., GSK-3 is essential in the pathogenesis of Alzheimer's disease (2006) J Alzheimers Dis, 9, pp. 309-317
Zhou, J., Liyanage, U., Medina, M., Presenilin 1 interaction in the brain with a novel member of the Armadillo family (1997) NeuroReport, 8, pp. 1489-1494
Takashima, A., Murayama, M., Murayama, O., Presenilin 1 associates with glycogen synthase kinase-3beta and its substrate tau (1998) Proc Natl Acad Sci USA, 95, pp. 9637-9641
Kang, D.E., Soriano, S., Xia, X., Presenilin couples the paired phosphorylation of beta-catenin independent of axin: Implications for beta-catenin activation in tumorigenesis (2002) Cell, 110, pp. 751-762
Zhang, Z., Hartmann, H., Do, V.M., Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis (1998) Nature, 395, pp. 698-702
De Ferrari, G.V., Moon, R.T., The ups and downs of Wnt signaling in prevalent neurological disorders (2006) Oncogene, 25, pp. 7545-7553
De Ferrari, G.V., Inestrosa, N.C., Wnt signaling function in Alzheimer's disease (2000) Brain Res Brain Res Rev, 33, pp. 1-12
De Ferrari, G.V., Chacón, M.A., Barría, M.I., Activation of Wnt signaling rescues neurodegeneration and behavioral impairments induced by beta-amyloid fibrils (2003) Mol Psychiatry, 8, pp. 195-208
Copani, A., Condorelli, F., Caruso, A., Mitotic signaling by beta-amyloid causes neuronal death (1999) FASEB J, 13, pp. 2225-2234
Copani, A., Caraci, F., Hoozemans, J.J., The nature of the cell cycle in neurons: Focus on a "non- canonical" pathway of DNA replication causally related to death (2007) Biochim Biophys Acta, 1772, pp. 409-412
Caricasole, A., Copani, A., Caraci, F., Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain (2004) J Neurosci, 24, pp. 6021-6027
De Ferrari, G.V., Papassotiropoulos, A., Biechele, T., Common genetic variation within the low-density lipoprotein receptor-related protein 6 and late-onset Alzheimer's disease (2007) Proc Natl Acad Sci USA, 104, pp. 9434-9439
Biagioni, F., Mastroiacovo, F., Busceti, C.L., Induction of transient focal brain ischemia induces the expression of the Wnt inhibitor, Dickkopf-1, in neurons of the perifocal regions in rats (2007) Soc Neurosci Abstr Program No. 493.22
Honavar, M., Meldrum, B.S., Graham, D.I., Lantos, P.I., Epilepsy (1997) Greenfield's Neuropathology, pp. 931-971. , 6 Arnold London
Busceti, C.L., Biagioni, F., Aronica, E., Induction of the Wnt inhibitor, Dickkopf-1, is associated with neurodegeneration related to temporal lobe epilepsy (2007) Epilepsia, 48, pp. 694-705
Zakzanis, K.K., Campbell, Z., Memory impairment in now abstinent MDMA users and continued users: A longitudinal follow-up (2006) Neurology, 66, pp. 740-741
Wu, D., Zhang, Y., Liu, P., Compositions and methods for bone formation and remodeling (2005), US Patent 2005/0196349Desbois-Mouthon, C., Cadoret, A., Blivet-Van Eggelpoël, M.J., Insulin and IGF-1 stimulate the beta-catenin pathway through two signalling cascades involving GSK-3beta inhibition and Ras activation (2001) Oncogene, 20, pp. 252-259
Caraci, F., Copani, A., Battaglia, G., A dual mechanism of neuroprotection by transforming growth factor-β1 against β-amyloid neurotoxicity (2006) Soc Neurosci Abstr Program No. 171.4
Torres Aleman, I., Role of insulin-like growth factors in neuronal plasticity and neuroprotection (2005) Adv Exp Med Biol, 567, pp. 243-258
Vivien, D., Ali, C., Transforming growth factor-beta signalling in brain disorders (2006) Cytokine Growth Factor Rev, 17, pp. 121-128
Huang, H.C., Klein, P.S., Multiple roles for glycogen synthase kinase-3 as a drug target in Alzheimer's disease (2006) Curr Drug Targets, 7, pp. 1389-1397
Wada, A., Yokoo, H., Yanagita, T., Lithium: Potential therapeutics against acute brain injuries and chronic neurodegenerative diseases (2005) J Pharmacol Sci, 99, pp. 307-321
Nunes, P.V., Forlenza, O.V., Gattaz, W.F., Lithium and risk for Alzheimer's disease in elderly patients with bipolar disorder (2007) Br J Psychiatry, 190, pp. 359-360
Dale, T. C., Signal transduction by the Wnt family of ligands (1998) Biochem J, 329, pp. 209-22
Miller, J. R., Hocking, A. M., Brown, J. D., Mechanism and function of signal transduction by the Wnt/beta-catenin and Wnt/Ca2+ pathways (1999) Oncogene, 18, pp. 7860-7872
Miller, J. R., The Wnts (2002) Genome Biol, 3, pp. 30011-300115. , 1
Moon, R. T., Bowerman, B., Boutros, M., The promise and perils of Wnt signaling through -catenin (2002) Science, 296, pp. 1644-1646
K hl, M., Sheldahl, L. C., Park, M., The Wnt/Ca2+pathway: A new vertebrate Wnt signaling pathway takes shape (2000) Trends Genet, 16, pp. 279-283
Salinas, P. C., Wnt factors in axonal remodelling and synaptogenesis (1999) Biochem Soc Symp, 65, pp. 101-109
Krupnik, V. E., Sharp, J. D., Jiang, C., Functional and structural diversity of the human Dickkopf gene family (1999) Gene, 238, pp. 301-313
Brott, B. K., Sokol, S. Y., Regulation of Wnt/LRP signalling by distinct domains of Dickkopf proteins (2002) Mol Cell Biol, 22, pp. 6100-6110
Diep, D. B., Hoen, N., Backman, M., Characterisation of the Wnt antagonists and their response to conditionally activated Wnt signalling in the developing mouse forebrain (2004) Brain Res Dev Brain Res, 153, pp. 261-270
Zorn, A. M., Wnt signalling: Antagonistic Dickkopfs (2001) Curr Biol, 11, pp. 592-R595
Slee, E. A., O'Connor, D. J., Lu, X., To die or not to die: How does p53 decide? (2004) Oncogene, 23, pp. 2809-2818
Choi, D. W., Calcium and excitotoxic neuronal injury (1994) Ann N Y Acad Sci, 747, pp. 162-171
Zipfel, G. J., Babcock, D. J., Lee, J. M., Neuronal apoptosis after CNS injury: The roles of glutamate and calcium (2000) J Neurotrauma, 17, pp. 857-869
Jope, R. S., Lithium and GSK-3: One inhibitor, two inhibitory actions, multiple outcomes (2003) Trends Pharmacol Sci, 24, pp. 441-443
Kang, D. E., Soriano, S., Xia, X., Presenilin couples the paired phosphorylation of beta-catenin independent of axin: Implications for beta-catenin activation in tumorigenesis (2002) Cell, 110, pp. 751-762
De Ferrari, G. V., Moon, R. T., The ups and downs of Wnt signaling in prevalent neurological disorders (2006) Oncogene, 25, pp. 7545-7553
Busceti, C. L., Biagioni, F., Aronica, E., Induction of the Wnt inhibitor, Dickkopf-1, is associated with neurodegeneration related to temporal lobe epilepsy (2007) Epilepsia, 48, pp. 694-705
Zakzanis, K. K., Campbell, Z., Memory impairment in now abstinent MDMA users and continued users: A longitudinal follow-up (2006) Neurology, 66, pp. 740-741
Huang, H. C., Klein, P. S., Multiple roles for glycogen synthase kinase-3 as a drug target in Alzheimer's disease (2006) Curr Drug Targets, 7, pp. 1389-1397
Nunes, P. V., Forlenza, O. V., Gattaz, W. F., Lithium and risk for Alzheimer's disease in elderly patients with bipolar disorder (2007) Br J Psychiatry, 190, pp. 359-360
Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2008 Dec; 33(12): 2401-2406.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 2.26, 5-year impact factor: 2.312
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-56349085908&partnerID=40&md5=a97e5a234e50a5bcab001baa23560cee
Keywords: β-Catenin, Canonical Wnt Pathway, Dkk-1, Lithium, Neurodegeneration, Neuronal Death, Amyloid Beta Protein, Dickkopf 1 Antagonist, Dickkopf 1 Protein, Kainic Acid, N Methyl Dextro Aspartic Acid, Unclassified Drug, Wnt Antagonist, Wnt Protein, Degenerative Disease, Excitotoxicity, Human, Nonhuman, Pathophysiology, Priority Journal, Protein Expression, Review, Temporal Lobe Epilepsy, Intercellular Signaling Peptides And Proteins, Neurodegenerative Diseases, Animalia,
Affiliations:
*** IBB - CNR ***
Department of Pharmaceutical Sciences, University of Catania, Viale Andrea Doria 6, 95125 Catania, Italy
I.N.M. Neuromed, Località Camerelle, 86077 Pozzilli, Italy
Department of Neuropathology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands
Department of Human Physiology and Pharmacology, University of Rome La Sapienza, 00185 Rome, Italy
Siena Biotech, Siena, Italy
I.B.B., CNR-Catania, 95125 Catania, Italy
I. N. M. Neuromed, Localit Camerelle, 86077 Pozzilli, Italy
I. B. B., CNR-Catania, 95125 Catania, Italy
References:
Dale, T.C., Signal transduction by the Wnt family of ligands (1998) Biochem J, 329, pp. 209-22
He, X., Semenov, M., Tamai, K., LDL receptor-related proteins 5 and 6 in Wnt/beta-catenin signaling: Arrows point the way (2004) Development, 131, pp. 1663-1677
Miller, J.R., Hocking, A.M., Brown, J.D., Mechanism and function of signal transduction by the Wnt/beta-catenin and Wnt/Ca2+ pathways (1999) Oncogene, 18, pp. 7860-7872
Prunier, C., Hocevar, B.A., Howe, P.H., Wnt signaling: Physiology and pathology (2004) Growth Factors, 22, pp. 141-150
Miller, J.R., The Wnts (2002) Genome Biol, 3, pp. 30011-300115. , 1
Moon, R.T., Bowerman, B., Boutros, M., The promise and perils of Wnt signaling through β-catenin (2002) Science, 296, pp. 1644-1646
Mlodzik, M., Planar cell polarization: Do the same mechanisms regulate Drosophila tissue polarity and vertebrate gastrulation? (2002) Trends Genet, 18, pp. 564-571
Kühl, M., Sheldahl, L.C., Park, M., The Wnt/Ca2+pathway: A new vertebrate Wnt signaling pathway takes shape (2000) Trends Genet, 16, pp. 279-283
Tamai, K., Semenov, M., Kato, Y., LDL-receptor-related proteins in Wnt signal transduction (2000) Nature, 407, pp. 530-535
Wehrli, M., Dougan, S.T., Caldwell, K., Arrow encodes an LDL-receptor-related protein essential for Wingless signalling (2000) Nature, 407, pp. 527-530
Liu, C., Li, Y., Semenov, M., Control of β-catenin phosphorylation/degradation by a dual-kinase mechanism (2002) Cell, 108, pp. 837-847
Aberle, H., Bauer, A., Stappert, J., Beta-catenin is a target for the ubiquitin-proteasome pathway (1997) EMBO J, 16, pp. 3797-3804
Willert, K., Nusse, R., Beta-catenin: A key mediator of Wnt signaling (1998) Curr Opin Genet Dev, 8, pp. 95-102
Willert, K., Jones, K.A., Wnt signaling: Is the party in the nucleus? (2006) Genes Dev, 20, pp. 1394-1404
Salinas, P.C., Wnt factors in axonal remodelling and synaptogenesis (1999) Biochem Soc Symp, 65, pp. 101-109
Yu, X., Malenka, R.C., Beta-catenin is critical for dendritic morphogenesis (2003) Nat Neurosci, 6, pp. 1169-1177
Murase, S., Mosser, E., Schuman, E.M., Depolarization drives beta-catenin into neuronal spines promoting changes in synaptic structure and function (2002) Neuron, 35, pp. 91-105
Niehrs, C., Function and biological roles of the Dickkopf family of Wnt modulators (2006) Oncogene, 25, pp. 7469-7481
Krupnik, V.E., Sharp, J.D., Jiang, C., Functional and structural diversity of the human Dickkopf gene family (1999) Gene, 238, pp. 301-313
Brott, B.K., Sokol, S.Y., Regulation of Wnt/LRP signalling by distinct domains of Dickkopf proteins (2002) Mol Cell Biol, 22, pp. 6100-6110
Diep, D.B., Hoen, N., Backman, M., Characterisation of the Wnt antagonists and their response to conditionally activated Wnt signalling in the developing mouse forebrain (2004) Brain Res Dev Brain Res, 153, pp. 261-270
Grotewold, L., Ruther, U., The Wnt antagonist Dickkopf-1 is 675 regulated by Bmp signaling and c-Jun and modulates programmed cell death (2002) EMBO J, 21, pp. 966-975
Glinka, A., Wu, W., Delius, H., Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction (1998) Nature, 391, pp. 357-362
Zorn, A.M., Wnt signalling: Antagonistic Dickkopfs (2001) Curr Biol, 11, pp. 592-R595
Mao, B., Niehrs, C., Kremen2 modulates Dickkopf2 activity during Wnt/LRP6 signaling (2003) Gene, 302, pp. 179-183
Wang, J., Shou, J., Chen, X., Dickkopf-1, an inhibitor of the Wnt signaling pathway, is induced by p53 (2000) Oncogene, 19, pp. 1843-1848
Slee, E.A., O'Connor, D.J., Lu, X., To die or not to die: How does p53 decide? (2004) Oncogene, 23, pp. 2809-2818
Choi, D.W., Calcium and excitotoxic neuronal injury (1994) Ann N Y Acad Sci, 747, pp. 162-171
Zipfel, G.J., Babcock, D.J., Lee, J.M., Neuronal apoptosis after CNS injury: The roles of glutamate and calcium (2000) J Neurotrauma, 17, pp. 857-869
Bruno, V., Battaglia, G., Copani, A., Metabotropic glutamate receptor subtypes as targets for neuroprotective drugs (2001) J Cereb Blood Flow Metab, 21, pp. 1013-1033
Cappuccio, I., Calderone, A., Busceti, C.L., Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is required for the development of ischemic neuronal death (2005) J Neurosci, 25, pp. 2647-2657
Jope, R.S., Lithium and GSK-3: One inhibitor, two inhibitory actions, multiple outcomes (2003) Trends Pharmacol Sci, 24, pp. 441-443
Scali, C., Caraci, F., Gianfriddo, M., Inhibition of Wnt signaling, modulation of Tau phosphorylation and induction of neuronal cell death by DKK1 (2006) Neurobiol Dis, 24, pp. 254-265
Oddo, S., Caccamo, A., Kitazawa, M., Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease (2003) Neurobiol Aging, 24, pp. 1063-1070
Blurton-Jones, M., Laferla, F.M., Pathways by which Abeta facilitates tau pathology (2006) Curr Alzheimer Res, 3, pp. 437-448
Takashima, A., Honda, T., Yasutake, K., Activation of tau protein kinase I/glycogen synthase kinase-3beta by amyloid beta peptide (25-35) enhances phosphorylation of tau in hippocampal neurons (1998) J Neurosci Res, 31, pp. 317-323
Takashima, A., GSK-3 is essential in the pathogenesis of Alzheimer's disease (2006) J Alzheimers Dis, 9, pp. 309-317
Zhou, J., Liyanage, U., Medina, M., Presenilin 1 interaction in the brain with a novel member of the Armadillo family (1997) NeuroReport, 8, pp. 1489-1494
Takashima, A., Murayama, M., Murayama, O., Presenilin 1 associates with glycogen synthase kinase-3beta and its substrate tau (1998) Proc Natl Acad Sci USA, 95, pp. 9637-9641
Kang, D.E., Soriano, S., Xia, X., Presenilin couples the paired phosphorylation of beta-catenin independent of axin: Implications for beta-catenin activation in tumorigenesis (2002) Cell, 110, pp. 751-762
Zhang, Z., Hartmann, H., Do, V.M., Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis (1998) Nature, 395, pp. 698-702
De Ferrari, G.V., Moon, R.T., The ups and downs of Wnt signaling in prevalent neurological disorders (2006) Oncogene, 25, pp. 7545-7553
De Ferrari, G.V., Inestrosa, N.C., Wnt signaling function in Alzheimer's disease (2000) Brain Res Brain Res Rev, 33, pp. 1-12
De Ferrari, G.V., Chacón, M.A., Barría, M.I., Activation of Wnt signaling rescues neurodegeneration and behavioral impairments induced by beta-amyloid fibrils (2003) Mol Psychiatry, 8, pp. 195-208
Copani, A., Condorelli, F., Caruso, A., Mitotic signaling by beta-amyloid causes neuronal death (1999) FASEB J, 13, pp. 2225-2234
Copani, A., Caraci, F., Hoozemans, J.J., The nature of the cell cycle in neurons: Focus on a "non- canonical" pathway of DNA replication causally related to death (2007) Biochim Biophys Acta, 1772, pp. 409-412
Caricasole, A., Copani, A., Caraci, F., Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain (2004) J Neurosci, 24, pp. 6021-6027
De Ferrari, G.V., Papassotiropoulos, A., Biechele, T., Common genetic variation within the low-density lipoprotein receptor-related protein 6 and late-onset Alzheimer's disease (2007) Proc Natl Acad Sci USA, 104, pp. 9434-9439
Biagioni, F., Mastroiacovo, F., Busceti, C.L., Induction of transient focal brain ischemia induces the expression of the Wnt inhibitor, Dickkopf-1, in neurons of the perifocal regions in rats (2007) Soc Neurosci Abstr Program No. 493.22
Honavar, M., Meldrum, B.S., Graham, D.I., Lantos, P.I., Epilepsy (1997) Greenfield's Neuropathology, pp. 931-971. , 6 Arnold London
Busceti, C.L., Biagioni, F., Aronica, E., Induction of the Wnt inhibitor, Dickkopf-1, is associated with neurodegeneration related to temporal lobe epilepsy (2007) Epilepsia, 48, pp. 694-705
Zakzanis, K.K., Campbell, Z., Memory impairment in now abstinent MDMA users and continued users: A longitudinal follow-up (2006) Neurology, 66, pp. 740-741
Wu, D., Zhang, Y., Liu, P., Compositions and methods for bone formation and remodeling (2005), US Patent 2005/0196349Desbois-Mouthon, C., Cadoret, A., Blivet-Van Eggelpoël, M.J., Insulin and IGF-1 stimulate the beta-catenin pathway through two signalling cascades involving GSK-3beta inhibition and Ras activation (2001) Oncogene, 20, pp. 252-259
Caraci, F., Copani, A., Battaglia, G., A dual mechanism of neuroprotection by transforming growth factor-β1 against β-amyloid neurotoxicity (2006) Soc Neurosci Abstr Program No. 171.4
Torres Aleman, I., Role of insulin-like growth factors in neuronal plasticity and neuroprotection (2005) Adv Exp Med Biol, 567, pp. 243-258
Vivien, D., Ali, C., Transforming growth factor-beta signalling in brain disorders (2006) Cytokine Growth Factor Rev, 17, pp. 121-128
Huang, H.C., Klein, P.S., Multiple roles for glycogen synthase kinase-3 as a drug target in Alzheimer's disease (2006) Curr Drug Targets, 7, pp. 1389-1397
Wada, A., Yokoo, H., Yanagita, T., Lithium: Potential therapeutics against acute brain injuries and chronic neurodegenerative diseases (2005) J Pharmacol Sci, 99, pp. 307-321
Nunes, P.V., Forlenza, O.V., Gattaz, W.F., Lithium and risk for Alzheimer's disease in elderly patients with bipolar disorder (2007) Br J Psychiatry, 190, pp. 359-360
Dale, T. C., Signal transduction by the Wnt family of ligands (1998) Biochem J, 329, pp. 209-22
Miller, J. R., Hocking, A. M., Brown, J. D., Mechanism and function of signal transduction by the Wnt/beta-catenin and Wnt/Ca2+ pathways (1999) Oncogene, 18, pp. 7860-7872
Miller, J. R., The Wnts (2002) Genome Biol, 3, pp. 30011-300115. , 1
Moon, R. T., Bowerman, B., Boutros, M., The promise and perils of Wnt signaling through -catenin (2002) Science, 296, pp. 1644-1646
K hl, M., Sheldahl, L. C., Park, M., The Wnt/Ca2+pathway: A new vertebrate Wnt signaling pathway takes shape (2000) Trends Genet, 16, pp. 279-283
Salinas, P. C., Wnt factors in axonal remodelling and synaptogenesis (1999) Biochem Soc Symp, 65, pp. 101-109
Krupnik, V. E., Sharp, J. D., Jiang, C., Functional and structural diversity of the human Dickkopf gene family (1999) Gene, 238, pp. 301-313
Brott, B. K., Sokol, S. Y., Regulation of Wnt/LRP signalling by distinct domains of Dickkopf proteins (2002) Mol Cell Biol, 22, pp. 6100-6110
Diep, D. B., Hoen, N., Backman, M., Characterisation of the Wnt antagonists and their response to conditionally activated Wnt signalling in the developing mouse forebrain (2004) Brain Res Dev Brain Res, 153, pp. 261-270
Zorn, A. M., Wnt signalling: Antagonistic Dickkopfs (2001) Curr Biol, 11, pp. 592-R595
Slee, E. A., O'Connor, D. J., Lu, X., To die or not to die: How does p53 decide? (2004) Oncogene, 23, pp. 2809-2818
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The Wnt antagonist, Dickkopf-1, as a target for the treatment of neurodegenerative disorders
The canonical Wnt pathway contributes to the regulation of neuronal survival and homeostasis in the CNS. Recent evidence suggests that an increased expression of Dickkopf-1 (Dkk-1), a secreted protein that negatively modulates the canonical Wnt pathway, is causally related to processes of neurodegeneration in a number of CNS disorders, including Alzheimer's disease (AD), brain ischemia and temporal lobe epilepsy (TLE). Dkk-1 induction precedes neuronal death in cellular and animal models of excitotoxicity, β-amyloid toxicity, transient global ischemia, and kainate-induced epilepsy. In addition, Dkk-1, which is barely visible in the healthy brain, is strongly induced in brain tissue from AD patients or from patients with TLE associated with hippocampal sclerosis. These data raise the attractive possibility that Dkk-1 antagonists or neutralizing antibodies behave as neuroprotective agents by rescuing the activity of the canonical Wnt pathway. © 2008 Springer Science+Business Media, LLC.
The canonical Wnt pathway contributes to the regulation of neuronal survival and homeostasis in the CNS. Recent evidence suggests that an increased expression of Dickkopf-1 (Dkk-1), a secreted protein that negatively modulates the canonical Wnt pathway, is causally related to processes of neurodegeneration in a number of CNS disorders, including Alzheimer's disease (AD), brain ischemia and temporal lobe epilepsy (TLE). Dkk-1 induction precedes neuronal death in cellular and animal models of excitotoxicity, β-amyloid toxicity, transient global ischemia, and kainate-induced epilepsy. In addition, Dkk-1, which is barely visible in the healthy brain, is strongly induced in brain tissue from AD patients or from patients with TLE associated with hippocampal sclerosis. These data raise the attractive possibility that Dkk-1 antagonists or neutralizing antibodies behave as neuroprotective agents by rescuing the activity of the canonical Wnt pathway. © 2008 Springer Science+Business Media, LLC.
The Wnt antagonist, Dickkopf-1, as a target for the treatment of neurodegenerative disorders
The Wnt antagonist, Dickkopf-1, as a target for the treatment of neurodegenerative disorders
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Copani A, Caraci F, Hoozemans J, Calafiore M, Sortino M, Nicoletti F
* The nature of the cell cycle in neurons: Focus on a "non-canonical" pathway of DNA replication causally related to death (496 views)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2007 Apr; 1772(4): 409-412.
Impact Factor: 3.078
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Giuffrida ML, Grasso G, Ruvo M, Pedone C, Saporito A, Marasco D, Pignataro B, Cascio C, Copani A, Rizzarelli E
* Abeta(25-35) And Its C- And/Or N-Blocked Derivatives: Copper Driven Structural Features And Neurotoxicity (613 views)
Journal Of Neuroscience Research (ISSN: 0360-4012), 2007 Feb 15; 85(3): 623-633.
Impact Factor: 3.268
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Copani A, Hoozemans JJM, Caraci F, Calafiore M, Van Haastert ES, Veerhuis R, Rozemuller AJM, Aronica E, Sortino MA, Nicoletti F
* Dna Polymerase-Beta Is Expressed Early In Neurons Of Alzheimer'S Disease Brain And Is Loaded Into Dna Replication Forks In Neurons Challenged With Beta-Amyloid (491 views)
J Neurosci (ISSN: 0270-6474, 0361-803x, 1529-2401), 2006; 26(43): 10949-10957.
Impact Factor: 2.117
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Calafiore M, Battaglia G, Zappal A, Trovato-Salinaro E, Caraci F, Caruso M, Vancheri C, Sortino MA, Nicoletti F, Copani A
* Progenitor cells from the adult mouse brain acquire a neuronal phenotype in response to β-amyloid (544 views)
Neurobiol Aging (ISSN: 0197-4580, 1558-1497electronic, 0197-4580linking), 2006; 27(4): 606-613.
Impact Factor: 5.599
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Marrazzo A, Caraci F, Salinaro ET, Su TP, Copani A, Ronsisvalle G
* Neuroprotective effects of sigma-1 receptor agonists against beta-amyloid-induced toxicity (584 views)
Neuroreport (ISSN: 0959-4965), 2005 Sep 1; 16(11): 1223-1226.
Impact Factor: 1.995
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Filippo C, Mariangela C, Giuseppina F, Pier Luigi C, Angelo B, Marco C, Giuseppe B, Paolo B, Ferdinando N, Agata C, Maria Angela S
* Nicergoline, a drug used for age-dependent cognitive impairment, protects cultured neurons against β-amyloid toxicity (797 views)
Brain Res (ISSN: 0006-8993), 2005; 1047(1): 30-37.
Impact Factor: 2.296
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Caricasole A, Copani A, Caraci F, Aronica E, Rozemuller AJ, Caruso A, Storto M, Gaviraghi G, Terstappen GC, Nicoletti F
* Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain (543 views)
J Neurosci (ISSN: 0270-6474, 0361-803x, 1529-2401), 2004 Jun 30; 24(26): 6021-6027.
Impact Factor: 2.384
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Wiesehan K, Buder K, Linke RP, Patt S, Stoldt M, Unger E, Schmitt B, Bucci E, Willbold D
* Selection of D-amino-acid peptides that bind to Alzheimer's disease amyloid peptide Aβ1-42 by mirror image phage display (709 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2003; 4(8): 748-753.
Impact Factor: 3.992
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Aime S, Dastrù W, Gobetto R, Viale A
An NMR study of H(μ-H)Os3(CO)11 (369 views)
Inorg Chem (ISSN: 0020-1669, 1520-510x, 1520-510xelectronic), 2000; 39(11): 2422-2425.
Impact Factor: 2.712
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* Validation of FDG-PET datasets of normal controls for the extraction of SPM-based brain metabolism maps (6 views)
Eur J Nucl Med Mol Imaging (ISSN: 1619-7070linking), 2021 Jul; 48(8): 2486-2499.
Impact Factor: 9.236
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Rendina A, Drongitis D, Donizetti A, Fucci L, Milan G, Tripodi F, Giustezza F, Postiglione A, Pappata S, Ferrari R, Bossù P, Angiolillo A, Di Costanzo A, Caiazzo M, Vitale E
* CD33 and SIGLECL1 Immunoglobulin Superfamily Involved in Dementia (94 views)
J Neuropathol Exp Neurol (ISSN: 0022-3069linking), 2020 Jul 10; 79(8): 891-901.
Impact Factor: 3.51
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Dubbioso R, Ruggiero L, Esposito M, Tarantino P, De Angelis M, Aruta F, Pappata S, Ugga L, Piperno A, Iorio R, Santoro L, Iodice R, Manganelli F
* Different cortical excitability profiles in hereditary brain iron and copper accumulation (131 views)
Neurol Sci (ISSN: 1590-1874linking, 1590-3478), 2020 Mar; 41(3): 679-685.
Impact Factor: 1.315
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Spampinato SF, Copani A, Nicoletti F, Sortino MA, Caraci F
* Metabotropic Glutamate Receptors in Glial Cells: A New Potential Target for Neuroprotection? (261 views)
Front Mol Neurosci (ISSN: 1662-5099, 1662-5099linking, 1662-5099electronic), 2018 Nov 13; 11: 414-414.
Impact Factor: 3.902
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Sciacca MFM, Monaco I, La Rosa C, Milardi D
* The active role of Ca(2+) ions in Abeta-mediated membrane damage (310 views)
Chem Commun (ISSN: 1364-548xelectronic, 1359-7345linking), 2018 Apr 5; 54(29): 3629-3631.
Impact Factor: 6.169
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Di Menna L, Joffe ME, Iacovelli L, Orlando R, Lindsley CW, Mairesse J, Gressèns P, Cannella M, Caraci F, Copani A, Bruno V, Battaglia G, Conn PJ, Nicoletti F
* Functional partnership between mGlu3 and mGlu5 metabotropic glutamate receptors in the central nervous system (396 views)
Neuropharm (ISSN: 0028-3908linking, 1873-7064electronic), 2018 Jan; 128: 301-313.
Impact Factor: 3.383
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Oliveri V, Zimbone S, Giuffrida ML, Bellia F, Tomasello MF, Vecchio G
* Porphyrin Cyclodextrin Conjugates Modulate Amyloid Beta Peptide Aggregation and Cytotoxicity (362 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2018; 24(24): 6349-6353.
Impact Factor: 5.476
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Caraci F, Nicoletti F, Copani A
* Metabotropic glutamate receptors: the potential for therapeutic applications in Alzheimer's disease (538 views)
Curr Opin Pharmacol (ISSN: 1471-4892), 2017 Dec 23; 38: 1-7.
Impact Factor: 6.313
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Sciacca MFM, Romanucci V, Zarrelli A, Monaco I, Lolicato F, Spinella N, Galati C, Grasso G, D'Urso L, Romeo M, Diomede L, Salmona M, Bongiorno C, Di Fabio G, La Rosa C, Milardi D
* Inhibition of Abeta Amyloid Growth and Toxicity by Silybins: The Crucial Role of Stereochemistry (401 views) (PDF 194 views)
Acs Chem Neurosci (ISSN: 1948-7193, 1948-7193electronic), 2017 Jun 09; N/D: N/D-N/D.
Impact Factor: 4.211
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Grasso G, Santoro AM, Lanza V, Sbardella D, Tundo GR, Ciaccio C, Marini S, Coletta M, Milardi D
* The double faced role of copper in Ab homeostasis: A survey on the interrelationship between metal dyshomeostasis, UPS functioning and autophagy in neurodegeneration (268 views)
Coordination Chemistry Reviews, 2017 Jun; N/D: 1-22.
Impact Factor: 13.324
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Florenzano F, Veronica C, Ciasca G, Ciotti MT, Pittaluga A, Olivero G, Feligioni M, Iannuzzi F, Latina V, Sciacca MFM, Sinopoli A, Milardi D, Pappalardo G, De Spirito M, Papi M, Atlante A, Bobba A, Borreca A, Calissano P, Amadoro G
* Extracellular truncated tau causes early presynaptic dysfunction associated with Alzheimer's disease and other tauopathies (262 views)
Oncotarget (ISSN: 1949-2553electronic, 1949-2553linking), 2017 Apr 22; N/D: N/D-N/D.
Impact Factor: 5.168
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Caraci F, Bruno V, Copani A, Matrisciano F, Nicoletti F, Battaglia G
* The impact of metabotropic glutamate receptors into active neurodegenerative processes: A "dark side" in the development of new symptomatic treatments for neurologic and psychiatric disorders (291 views)
Neuropharm (ISSN: 0028-3908, 1873-7064electronic, 0028-3908linking), 2017 Mar 15; 115: 180-192.
Impact Factor: 5.012
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Oliveri V, Bellia F, Vecchio G
* Cyclodextrin Nanoparticles Bearing 8-Hydroxyquinoline Ligands as Multifunctional Biomaterials (752 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2017; 23(18): 4442-4449.
Impact Factor: 5.16
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D'Andrea LD, Rosa LD, Vigliotti C, Cataldi M
* VEGF mimic peptides: Potential applications in central nervous system therapeutics (639 views)
New Horizons Transl Med (ISSN: 2307-5023), 2017; 3(5): 233-251.
Impact Factor: 0
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Nicastro MC, Spigolon D, Librizzi F, Moran O, Ortore MG, Bulone D, Biagio PLS, Carrotta R
* Amyloid β-peptide insertion in liposomes containing GM1-cholesterol domains (363 views)
Biophys Chem (ISSN: 0301-4622, 0301-4622linking), 2016; 208: 9-16.
Impact Factor: 2.402
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Oliveri V, Bellia F, Grasso GI, Pietropaolo A, Vecchio G
* Trehalose-8-hydroxyquinoline conjugates as antioxidant modulators of Aβ aggregation (942 views)
Rsc Adv (ISSN: 2046-2069), 2016; 6(53): 47229-47236.
Impact Factor: 3.108
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Giuffrida ML, Tomasello MF, Pandini G, Caraci F, Battaglia G, Busceti C, Di Pietro P, Pappalardo G, Attanasio F, Chiechio S, Bagnoli S, Nacmias B, Sorbi S, Vigneri R, Rizzarelli E, Nicoletti F, Copani A
* Monomeric ss-amyloid interacts with type-1 insulin-like growth factor receptors to provide energy supply to neurons (526 views)
Front Cell Neurosci (ISSN: 1662-5102), 2015 Aug 7; 9(AUGUST): 297-297.
Impact Factor: 4.609
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Caraci F, Pappalardo G, Basile L, Giuffrida A, Copani A, Tosto R, Sinopoli A, Giuffrida ML, Pirrone E, Drago F, Pignatello R, Guccione S
* Neuroprotective effects of the monoamine oxidase inhibitor Tranylcypromine and its amide derivatives against Abeta(1-42)-induced toxicity (758 views)
Eur J Pharmacol (ISSN: 0014-2999), 2015 Jul 7; 764: 256-263.
Impact Factor: 2.73
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Merlo S, Basile L, Giuffrida ML, Sortino MA, Guccione S, Copani A
* Identification of 5-Methoxyflavone as a Novel DNA Polymerase-Beta Inhibitor and Neuroprotective Agent against Beta-Amyloid Toxicity (323 views)
J Nat Prod (ISSN: 0163-3864), 2015; 78(11): 2704-2711.
Impact Factor: 3.662
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Altieri F, Di Stadio CS, Severino V, Sandomenico A, Minopoli G, Miselli G, Di Maro A, Ruvo M, Chambery A, Quagliariello V, Masullo M, Rippa E, Arcari P
* Anti-amyloidogenic property of human gastrokine (527 views)
Biochimie (ISSN: 0300-9084, 1638-6183, 0300-9084linking), 2014 Nov; 106C: 91-100.
Impact Factor: 2.963
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Salvatore E, Tedeschi E, Mollica C, Vicidomini C, Varrone A, Coda ARD, Brunetti A, Salvatore M, De Michele G, Filla A, Pappata S
* Supratentorial and infratentorial damage in spinocerebellar ataxia 2: a diffusion-weighted MRI study (376 views)
Mov Disord (ISSN: 0885-3185, 1531-8257, 0885-3185linking), 2014 May; 29(6): 780-786.
Impact Factor: 5.68
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Grasso GI, Arena G, Bellia F, Rizzarelli E, Vecchio G
* Copper(II)-chelating homocarnosine glycoconjugate as a new multifunctional compound (560 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2014 Feb; 131: 56-63.
Impact Factor: 3.444
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Doti N, Reuther C, Scognamiglio PL, Dolga AM, Plesnila N, Ruvo M, Culmsee C
* Inhibition of the AIF/CypA complex protects against intrinsic death pathways induced by oxidative stress (562 views)
Cell Death & (ISSN: 2041-4889, 2041-4889electronic), 2014 Jan 16; 5(1): e993-e993.
Impact Factor: 5.014
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Bellia F, Vecchio G, Rizzarelli E
* Carnosine and Cognitive Deficits (171 views)
Diet And Nutr In Dement And Cogn Decline (ISSN: 9780-1240793979780124078246), 2014; N/D: 973-982.
Impact Factor: 0
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Autiero I, Saviano M, Langella E
* In silico investigation and targeting of amyloid beta oligomers of different size (500 views)
Mol Biosyst (ISSN: 1742-206x, 1742-2051electronic), 2013 Aug; 9(8): 2118-2124.
Impact Factor: 3.18
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Booij J, Arbizu J, Darcourt J, Hesse S, Nobili F, Payoux P, Pappata S, Tatsch K, Walker Z, Pagani M
* Appropriate use criteria for amyloid PET imaging cannot replace guidelines: on behalf of the European Association of Nuclear Medicine (538 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2013 Jul; 40(7): 1122-1125.
Impact Factor: 5.217
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Attanasio F, Convertino M, Magno A, Caflisch A, Corazza A, Haridas H, Esposito G, Cataldo S, Pignataro B, Milardi D, Rizzarelli E
* Carnosine Inhibits Abeta(42) Aggregation By Perturbing The H-Bond Network In And Around The Central Hydrophobic Cluster (697 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2013 Mar 18; 14(5): 583-592.
Impact Factor: 3.06
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Pandini G, Pace V, Copani A, Squatrito S, Milardi D, Vigneri R
* Insulin has multiple antiamyloidogenic effects on human neuronal cells (628 views)
Endocrinology (ISSN: 0013-7227, 1945-7170), 2013 Jan; 154(1): 375-387.
Impact Factor: 4.644
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Pannuzzo M, Milardi D, Raudino A, Karttunen M, La Rosa C
* Analytical model and multiscale simulations of Aβ peptide aggregation in lipid membranes: Towards a unifying description of conformational transitions, oligomerization and membrane damage (728 views)
Phys Chem Chem Phys (ISSN: 1463-9076, 1463-3907, 1463-9084electronic), 2013; 15(23): 8940-8951.
Impact Factor: 4.198
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Attanasio F, De Bona P, Cataldo S, Sciacca MFM, Milardi D, Pignataro B, Pappalardo G
* Copper(II) and zinc(II) dependent effects on A beta 42 aggregation: a CD, Th-T and SFM study (456 views)
New J Chem (ISSN: 1144-0546), 2013; 37(4): 1206-1215.
Impact Factor: 3.159
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Autiero I, Langella E, Saviano M
* Insights Into The Mechanism Of Interaction Between Trehalose-Conjugated Beta-Sheet Breaker Peptides And Aβ(1-42) Fibrils By Molecular Dynamics Simulations (572 views)
Molecular Biosystems (ISSN: 1742-206x, 1742-2206), 2013; 9(11): 2835-2841.
Impact Factor: 3.18
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Giuffrida ML, Tomasello F, Caraci F, Chiechio S, Nicoletti F, Copani A
* Beta-Amyloid monomer and insulin/IGF-1 signaling in Alzheimer's disease (1070 views)
Mol Neurobiol (ISSN: 0893-7648), 2012 Dec; 46(3): 605-613.
Impact Factor: 5.471
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Caraci F, Battaglia G, Sortino MA, Spampinato S, Molinaro G, Copani A, Nicoletti F, Bruno V
* Metabotropic glutamate receptors in neurodegeneration/neuroprotection: Still a hot topic? (626 views)
Neurochem Int (ISSN: 0197-0186), 2012 Sep; 61(4): 559-565.
Impact Factor: 2.659
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Grasso G, Giuffrida ML, Rizzarelli E
* Metallostasis And Amyloid Beta-Degrading Enzymes (932 views)
Metallomics (ISSN: 1756-5901, 1756-591x, 1756-591xelectronic), 2012 Sep; 4(9): 937-949.
Impact Factor: 4.099
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Calafiore M, Copani A, Deng W
* DNA polymerase-β mediates the neurogenic effect of β-amyloid protein in cultured subventricular zone neurospheres (597 views)
Journal Of Neuroscience Research (ISSN: 0360-4012), 2012 Mar; 90(3): 559-567.
Impact Factor: 2.974
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Caraci F, Spampinato S, Sortino MA, Bosco P, Battaglia G, Bruno V, Drago F, Nicoletti F, Copani A
* Dysfunction of TGF-β1 signaling in Alzheimer's disease: Perspectives for neuroprotection (987 views)
Cell Tissue Res (ISSN: 0302-766x), 2012 Jan; 347(1): 291-301.
Impact Factor: 3.677
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Arena G, Fattorusso R, Grasso G, Grasso GI, Isernia C, Malgieri G, Milardi D, Rizzarelli E
* Zinc(II) complexes of ubiquitin: speciation, affinity and binding features (559 views)
Chemistry (ISSN: 1521-3765, 0947-6539, 1521-3765electronic), 2011 Oct 4; 17(41): 11596-11603.
Impact Factor: 5.925
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Bellia F, Vecchio G, Cuzzocrea S, Calabrese V, Rizzarelli E
* Neuroprotective features of carnosine in oxidative driven diseases (424 views)
Molecular Aspects Of Medicine (ISSN: 1872-9452, 0098-2997), 2011 Sep; 32(4-6): 258-266.
Impact Factor: 9.97
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Damante CA, Ösz K, Nagy Z, Grasso G, Pappalardo G, Rizzarelli E, Sóvágó I
* Zn2+'s ability to alter the distribution of Cu2+ among the available binding sites of A beta(1-16)-polyethylenglycol-ylated peptide: Implications in Alzheimer's disease (455 views)
Inorg Chem (ISSN: 0020-1669, 1520-510x, 1520-510xelectronic), 2011 Jun 20; 50(12): 5342-5350.
Impact Factor: 4.601
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Corona C, Frazzini V, Silvestri E, Lattanzio R, La Sorda R, Piantelli M, Canzoniero LM, Ciavardelli D, Rizzarelli E, Sensi SL
* Effects of dietary supplementation of carnosine on mitochondrial dysfunction, amyloid pathology, and cognitive deficits in 3xTg-AD mice (553 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2011 Mar 15; 6(3): e17971-e17971.
Impact Factor: 4.092
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Caraci F, Molinaro G, Battaglia G, Giuffrida ML, Riozzi B, Traficante A, Bruno V, Cannella M, Merlo S, Wang X, Heinz BA, Nisenbaum ES, Britton TC, Drago F, Sortino MA, Copani A, Nicoletti F
* Targeting group II Metabotropic Glutamate (mGlu) receptors for the treatment of psychosis associated with alzheimer's disease: Selective activation of mGlu2 receptors amplifies β-amyloid toxicity in cultured neurons, whereas dual activation of mGlu2 and mGlu3 receptors is neuroprotective (748 views)
Mol Pharmacol (ISSN: 0026-895x), 2011 Mar; 79(3): 618-626.
Impact Factor: 4.883
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Grasso G, Pietropaolo A, Spoto G, Pappalardo G, Tundo GR, Ciaccio C, Coletta M, Rizzarelli E
* Copper(I) and Copper(II) Inhibit A beta Peptides Proteolysis by Insulin-Degrading Enzyme Differently: Implications for Metallostasis Alteration in Alzheimer's Disease (576 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2011 Feb 25; 17(9): 2752-2762.
Impact Factor: 5.925
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Józsa E, Osz K, Kállay C, de Bona P, Damante CA, Pappalardo G, Rizzarelli E, Sóvágó I
* Nickel(ii) and mixed metal complexes of amyloid-β N-terminus (448 views)
Dalton T (ISSN: 1477-9226, 1477-9234, 1477-9234electronic), 2010 Sep 14; 39(30): 7046-7053.
Impact Factor: 3.647
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Jozsa E, Hosz K, Kallay C, De Bona P, Damante CA, Pappalardo G, Rizzarelli E, Sovago I
* Nickel (ii) And Mixed Metal Complexes Of Amyloid-B N-Terminus. Results Of Potentiometric And Spectroscopic Studies On The Binary Nickel (ii) And Mixed Metal Nickel (ii)-Copper (ii) And Nickel (ii)-Copper (ii)-Zinc (ii) Complexes Of Peptide Fragments (489 views)
Dalton T (ISSN: 1477-9226, 1477-9234, 1477-9234electronic), 2010; 39(30): 7046-7053.
Impact Factor: 3.647
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Giuffrida ML, Caraci F, De Bona P, Pappalardo G, Nicoletti F, Rizzarelli E, Copani A
* The monomer state of beta-amyloid: where the Alzheimer's disease protein meets physiology (675 views)
Rev Neurosci (ISSN: 0334-1763), 2010; 21(2): 83-93.
Impact Factor: 2.047
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Damante CA, Osz K, Nagy Z, Pappalardo G, Grasso G, Impellizzeri G, Rizzarelli E, Sóvágó I
* Metal Loading Capacity Of Abeta N-Terminus: A Combined Potentiometric And Spectroscopic Study Of Zinc (ii) Complexes With Abeta (1-16), Its Short Or Mutated Peptide Fragments And Its Polyethylene Glycol-Ylated Analogue (480 views)
Inorg Chem (ISSN: 0020-1669, 1520-510x, 1520-510xelectronic), 2009 Nov 2; 48(21): 10405-10415.
Impact Factor: 4.657
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Giuffrida ML, Caraci F, Pignataro B, Cataldo S, De Bona P, Bruno V, Molinaro G, Pappalardo G, Messina A, Palmigiano A, Garozzo D, Nicoletti F, Rizzarelli E, Copani A
* Beta-Amyloid Monomers Are Neuroprotective (659 views)
J Neurosci (ISSN: 1529-2401, 0270-6474), 2009 Sep 26; 29(34): 10582-10587.
Impact Factor: 3.669
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La Mendola D, Pietropaolo A, Pappalardo G, Zannoni C, Rizzarelli E
* Prion Proteins Leading to Neurodegeneration (vol 5, pg 579, 2008) (233 views)
Current Alzheimer Research (ISSN: 1567-2050), 2009 Jun; 6(3): N/D-N/D.
Impact Factor: 4.971
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De Bona P, Giuffrida ML, Caraci F, Copani A, Pignataro B, Attanasio F, Cataldo S, Pappalardo G, Rizzarelli E
* Design And Synthesis Of New Trehalose-Conjugated Pentapeptides As Inhibitors Of Abeta (1-42) Fibrillogenesis And Toxicity (688 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 220-228.
Impact Factor: 1.807
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D'Auria G, Vacatello M, Falcigno L, Paduano L, Mangiapia G, Calvanese L, Gambaretto R, Dettin M, Paolillo L
* Self-assembling properties of ionic-complementary peptides (486 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 210-219.
Impact Factor: 1.807
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Ciaccio C, Tundo GR, Grasso G, Spoto G, Marasco D, Ruvo M, Gioia M, Rizzarelli E, Coletta M
* Somatostatin: a novel substrate and a modulator of insulin-degrading enzyme activity (454 views)
J Mol Biol (ISSN: 1089-8638, 0022-2836, 1089-8638electronic), 2009 Feb 6; 385(5): 1556-1567.
Impact Factor: 3.871
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La Mendola D, Pietropaolo A, Pappalardo G, Zannoni C, Rizzarelli E
* Prion proteins leading to neurodegeneration (420 views)
Current Alzheimer Research (ISSN: 1567-2050), 2008 Dec; 5(6): 579-590.
Impact Factor: 4.132
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Damante CA, Ösz K, Nagy Z, Pappalardo G, Grasso G, Impellizzeri G, Rizzarelli E, Sóvágó I
* The Metal Loading Ability Of Beta-Amyloid N-Terminus: A Combined Potentiometric And Spectroscopic Study Of Copper (ii) Complexes With Beta-Amyloid (1-16), Its Short Or Mutated Peptide Fragments, And Its Polyethylene Glycol (peg)-Ylated Analogue (569 views)
Inorg Chem (ISSN: 0020-1669, 1520-510x, 1520-510xelectronic), 2008 Oct 20; 47(20): 9669-9683.
Impact Factor: 4.147
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Caraci F, Battaglia G, Busceti C, Biagioni F, Mastroiacovo F, Bosco P, Drago F, Nicoletti F, Sortino MA, Copani A
* TGF-β1 protects against Aβ-neurotoxicity via the phosphatidylinositol-3-kinase pathway (408 views)
Neurobiology Of Disease (ISSN: 0969-9961), 2008 May; 30(2): 234-242.
Impact Factor: 4.852
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Bellia F, Amorini AM, La Mendola D, Vecchio G, Tavazzi B, Giardina B, Di Pietro V, Lazzarino G, Rizzarelli E
* New glycosidic derivatives of histidine-containing dipeptides with antioxidant properties and resistant to carnosinase activity (444 views)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 1768-3254electronic), 2008 Feb; 43(2): 373-380.
Impact Factor: 2.882
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Copani A, Guccione S, Giurato L, Caraci F, Calafiore M, Sortino MA
* The cell cycle molecules behind neurodegeneration in Alzheimer's disease: Perspectives for drug development (452 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2008; 15(24): 2420-2432.
Impact Factor: 4.823
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Copani A, Caraci F, Hoozemans J, Calafiore M, Sortino M, Nicoletti F
* The nature of the cell cycle in neurons: Focus on a "non-canonical" pathway of DNA replication causally related to death (496 views)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2007 Apr; 1772(4): 409-412.
Impact Factor: 3.078
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Giuffrida ML, Grasso G, Ruvo M, Pedone C, Saporito A, Marasco D, Pignataro B, Cascio C, Copani A, Rizzarelli E
* Abeta(25-35) And Its C- And/Or N-Blocked Derivatives: Copper Driven Structural Features And Neurotoxicity (613 views)
Journal Of Neuroscience Research (ISSN: 0360-4012), 2007 Feb 15; 85(3): 623-633.
Impact Factor: 3.268
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Copani A, Hoozemans JJM, Caraci F, Calafiore M, Van Haastert ES, Veerhuis R, Rozemuller AJM, Aronica E, Sortino MA, Nicoletti F
* Dna Polymerase-Beta Is Expressed Early In Neurons Of Alzheimer'S Disease Brain And Is Loaded Into Dna Replication Forks In Neurons Challenged With Beta-Amyloid (491 views)
J Neurosci (ISSN: 0270-6474, 0361-803x, 1529-2401), 2006; 26(43): 10949-10957.
Impact Factor: 2.117
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Calafiore M, Battaglia G, Zappal A, Trovato-Salinaro E, Caraci F, Caruso M, Vancheri C, Sortino MA, Nicoletti F, Copani A
* Progenitor cells from the adult mouse brain acquire a neuronal phenotype in response to β-amyloid (544 views)
Neurobiol Aging (ISSN: 0197-4580, 1558-1497electronic, 0197-4580linking), 2006; 27(4): 606-613.
Impact Factor: 5.599
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Marrazzo A, Caraci F, Salinaro ET, Su TP, Copani A, Ronsisvalle G
* Neuroprotective effects of sigma-1 receptor agonists against beta-amyloid-induced toxicity (584 views)
Neuroreport (ISSN: 0959-4965), 2005 Sep 1; 16(11): 1223-1226.
Impact Factor: 1.995
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Filippo C, Mariangela C, Giuseppina F, Pier Luigi C, Angelo B, Marco C, Giuseppe B, Paolo B, Ferdinando N, Agata C, Maria Angela S
* Nicergoline, a drug used for age-dependent cognitive impairment, protects cultured neurons against β-amyloid toxicity (797 views)
Brain Res (ISSN: 0006-8993), 2005; 1047(1): 30-37.
Impact Factor: 2.296
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Caricasole A, Copani A, Caraci F, Aronica E, Rozemuller AJ, Caruso A, Storto M, Gaviraghi G, Terstappen GC, Nicoletti F
* Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain (543 views)
J Neurosci (ISSN: 0270-6474, 0361-803x, 1529-2401), 2004 Jun 30; 24(26): 6021-6027.
Impact Factor: 2.384
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Wiesehan K, Buder K, Linke RP, Patt S, Stoldt M, Unger E, Schmitt B, Bucci E, Willbold D
* Selection of D-amino-acid peptides that bind to Alzheimer's disease amyloid peptide Aβ1-42 by mirror image phage display (709 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2003; 4(8): 748-753.
Impact Factor: 3.992
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Aime S, Dastrù W, Gobetto R, Viale A
An NMR study of H(μ-H)Os3(CO)11 (369 views)
Inorg Chem (ISSN: 0020-1669, 1520-510x, 1520-510xelectronic), 2000; 39(11): 2422-2425.
Impact Factor: 2.712
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65 Records (62 excluding Abstracts).
Total impact factor: 265.105 (251.028 excluding Abstracts).
Total 5 year impact factor: 257.65 (243.824 excluding Abstracts).
Total impact factor: 265.105 (251.028 excluding Abstracts).
Total 5 year impact factor: 257.65 (243.824 excluding Abstracts).
388 views. Last view on Sunday 26 March 2023, 11:35:57
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