The cell cycle molecules behind neurodegeneration in Alzheimer's disease: Perspectives for drug development (452 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2008; 15(24): 2420-2432.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 4.823, 5-year impact factor: 5.291
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-55249091338&partnerID=40&md5=55dc351fc333115ed6dbdf77e3158e24
Keywords: β-Amyloid, Alzheimer, S Disease, Apoptosis, Cell Cycle, Cyclin-Dependent Kinases, Dna Polymerase-β, Dna Replication, Neuroprotection, Amyloid Beta Protein, Cyclin Dependent Kinase 1, Cyclin Dependent Kinase Inhibitor, Dna Directed Dna Polymerase Beta, Flavopiridol, Mimosine, Olomoucine, Protein P53, Roscovitine, Zalcitabine, Neuroprotective Agent, Alzheimer Disease, Binding Site, Cell Cycle Arrest, Cell Cycle G1 Phase, Cell Cycle Progression, Cell Cycle S Phase, Cell Proliferation, Clinical Trial, Creatinine Blood Level, Diarrhea, Dna Repair, Dna Synthesis, Drug Efficacy, Drug Eruption, Drug Potency, Drug Selectivity, Drug Structure, Drug Targeting, Gene Activation, Gene Mutation, Gene Targeting, Human, Nausea, Nerve Degeneration, Neurofibrillary Tangle, Nonhuman, Pathogenesis, Review, Side Effect, Vomiting, Animal, Biological Model, Drug Effect, Drug Screening, Metabolism, Pathology, Drug Evaluation, Preclinical, Neurological,
Affiliations:
*** IBB - CNR ***
Department of Pharmaceutical Sciences, University of Catania, Viale A. Doria 6, 95125 Catania, Italy
I.B.B., CNR-Catania, Catania, Italy
Department of Experimental and Clinical Pharmacology, University of Catania, Viale A. Doria 6, 95125 Catania, Italy
Department of Human Physiology and Pharmacology, University of Rome La Sapienza, Italy
I.N.M. Neuromed, Pozzilli, Italy
I. B. B., CNR-Catania, Catania, Italy
I. N. M. Neuromed, Pozzilli, Italy
References:
Zhu, C.W., Sano, M., (2006) Clin. Interv. Aging, 1, p. 4
Loveman, E., Green, C., Kirby, J., Takeda, A., Picot, J., Payne, E., Clegg, A., (2006) Health Technol. Assess, 10, p. 1
Katzman, K., (1986) N. Engl. J. Med, 314, p. 964
Selkoe, D.J., (2001) Physiol. Rev, 81, p. 741
Walsh, D.M., Selkoe, D.J., (2007) J. Neurochem, 101, p. 1172
Blurton-Jones, M., Laferla, F.M., (2006) Curr. Alzheimer Res, 5, p. 437
Herrup, K., Neve, R., Ackerman, S.L., Copani, A., (2004) J. Neurosci, 24, p. 9232
Van Den Heuvel, S., Harlow, E., (1993) Science, 262, p. 2050
Harbour, J.W., Luo, R.X., Del Santi, A., Postigo, A.A., Dean, D.C., (1999) Cell, 98, p. 859
Ren, S., Rollins, B.J., (2004) Cell, 117, p. 239
Morgan, D.O., (1997) Annu. Rev. Cell Dev. Biol, 13, p. 261
Nigg, E.A., (1996) Curr. Opin. Cell Biol, 8, p. 312
Lee, M.H., Yang, H.Y., (2001) Cell. Mol. Life Sci, 58, p. 1907
Russo, A.A., Jeffery, P.D., Patten, A.K., Massagué, J., Pavletich, N.P., (1996) Nature, 382, p. 325
Ekholm, S.V., Reed, S.I., (2000) Curr. Opin. Cell Biol, 12, p. 676
Malumbres, M., Barbacid, M., (2001) Nat. Rev. Cancer, 1, p. 222
el-Deiry, W.S., Tokino, T., Velculescu, V.E., Levy, D.B., Parsons, R., Trent, J.M., Lin, D., Vogelstein, B., (1993) Cell, 75, p. 817
Haupt, S., Berger, M., Goldberg, Z., Haupt, Y., (2003) J. Cell Sci, 116, p. 4077
Haupt, S., Haupt, Y., (2006) Anticancer Drugs, 17, p. 725
Vousden, K.H., Lu, X., (2002) Nat. Rev. Cancer, 2, p. 594
Kastan, M.B., Lim, D.S., (2000) Nat. Rev. Mol. Cell Biol, 1, p. 179
Niida, H., Nakanishi, M., (2006) Mutagenesis, 21, p. 3
Liu, Q., Guntuku, S., Cui, X.S., Matsuoka, S., Cortez, D., Tamai, K., Luo, G., Elledge, S.J., (2000) Genes Dev, 14, p. 1448
Pommier, Y., Sordet, O., Rao, V.A., Zhang, H., Kohn, K.W., (2005) Curr. Pharm. Des, 11, p. 2855
Hubscher, U., Nasheuer, H.P., Syvaoia, J.E., (2000) Trends Biochem. Sci, 25, p. 143
Arezi, B., Kuchta, R.D., (2000) Trends Biochem. Sci, 25, p. 572
Friedberg, E.C., (2006) Nat. Rev. Mol. Cell Biol, 2, p. 143
Burgers, P.M., (1998) Chromosoma, 107, p. 218
Kelly, T.J., Brown, G.W., (2000) Annu. Rev. Biochem, 68, p. 829
Bell, S.P., Dutta, A., (2002) Annu. Rev. Biochem, 71, p. 333
Dhar, S.K., Delmolino, L., Dutta, A., (2001) J. Biol. Chem, 276, p. 29067
Tsurimoto, T., Stillman, B., (1991) J. Biol. Chem, 266, p. 1961
Michael, W.M., Ott, R., Fanning, E., Newport, J., (2000) Science, 289, p. 2133
Dantzer, F., Nasheuer, H.P., Vonesch, J.L., de Murcia, G., Ménissier-de Murcia, J., (1998) Nucleic Acids Res, 26, p. 1891
Kelman, Z., (1997) Oncogene, 14, p. 629
Holmes, J., Clark, S., Modrich, P., (1990) Proc. Natl. Acad. Sci. USA, 87, p. 5837
Stucki, M., Pascucci, B., Parlanti, E., Fortini, P., Wilson, S.H., Hubscher, U., Dogliotti, E., (1998) Oncogene, 17, p. 835
Sobol, R., Horton, J., Kuhn, R., Gu, H., Prasad, R., Rajewsky, K., Wilson, S.H., (1996) Nature, 379, p. 183
Matsumoto, Y., Kim, K., (1995) Science, 269, p. 699
Piersen, C.E., Prasad, R., Wilson, S.H., Lloyd, R.S., (1996) J. Biol. Chem, 271, p. 17811
Pelletier, H., Sawaya, M.R., Kumar, A., Wilson, S.H., Kraut, J., (1994) Science, 264, p. 1891
Kunkel, T., (1985) J. Biol. Chem, 260, p. 5787
Friedberg, E.C., Wagner, R., Radman, M., (2002) Science, 296, p. 1627
Canitrot, Y., Frechet, M., Servant, L., Cazaux, C., Hoffmann, J.S., (1999) FASEB J, 13, p. 1107
Canitrot, Y., Cazaux, C., Frechet, M., Bouayadi, K., Lesca, C., Salles, B., Hoffmann, J.S., (1998) Proc. Natl. Acad. Sci. USA, 95, p. 12586
Servant, L., Bieth, A., Hayakawa, H., Cazaux, C., Hoffmann, J.-S., (2002) J. Mol. Biol, 315, p. 1039
Canitrot, Y., Hoffmann, J.S., Calsou, P., Hayakawa, H., Salles, B., Cazaux, C., (2000) FASEB J, 14, p. 1765
Srivastava, D.K., Husain, I., Arteaga, C.L., Wilson, S.H., (1999) Carcinogenesis, 20, p. 1049
and Wilson, S.H. Nucleic Acids Res., 1988, 16, 9589Sweasy, J., Loeb, L., (1992) J. Biol. Chem, 267, p. 1407
Siegel, R.L., Kalf, G.F., (1982) J. Biol. Chem, 257, p. 1785
Vincent, I., Rosado, M., Davies, P., (1996) J. Cell Biol, 132, p. 413
Busser, J., Geldmacher, D.S., Herrup, K., (1998) J. Neurosci, 18, p. 2801
Nagy, Z., Esiri, M.M., Smith, A.D., (1997) Acta Neuropathol, 93, p. 294
Smith, M.A. Am. J. Pathol., 1997, 150, 1933Arendt, T., Holzer, M., Gartner, U., Bruckner, M.K., (1998) J. Neural. Transm. Suppl, 54, p. 147
Yang, Y., Mufson, E.J., Herrup, K., (2003) J. Neurosci, 23, p. 2557
Bennet, D.A., Wilson, R.S., Schneider, J.A., Evans, D.A., Beckett, L.A., Aggarwal, N.T., Barnes, L.L., Bach, J., (2002) Neurology, 59, p. 198
Yang, Y., Geldmacher, D.S., Herrup, K., (2001) J. Neurosci, 21, p. 2661
Dranovsky, A., Vincent, I., Gregori, L., Schwarzman, A., Colflesh, D., Enghild, J., Strittmatter, W., Goldgaber, D., (2001) Neurobiol. Aging, 22, p. 517
Paudel, H.K., Lew, J., Ali, Z., Wang, J.H., (1993) J. Biol. Chem, 268, p. 23512
Pei, J.J., Braak, H., Gong, C.X., Grundke-Iqbal, I., Iqbal, K., Winblad, B., Cowburn, R.F., (2002) Acta Neuropathol, 104, p. 369
Yang, Y., Varvel, N.H., Lamb, B.T., Herrup, K., (2006) J. Neurosci, 26, p. 775
Hock Jr., B.J., Lamb, B.T., (2001) Trends Genet, 17, pp. S7
Ueberham, U., Arendt, T., (2005) Curr. Drug Targets CNS Neurol. Disord, 4, p. 293
Huang, Z., Zang, K., Reichardt, L.F., (2005) J. Cell Biol, 170, p. 527
Teng, F.Y.H., Tang, B.L., (2005) Cell. Mol. Life Sci, 62, p. 1571
Lee, S.S., Kim, Y.M., Junn, E., Lee, G., Park, H.K., Tanaka, M., Ronchetti, R.D., Mouradian, M.M., (2003) Neurobiol. Aging, 24, p. 687
Husseman, J.W., Nochlin, D., Vincent, I., (2000) Neurobiol. Aging, 21, p. 815
Ranganathan, S., Scudiere, S., Bowser, R.J., (2001) Alzheimer's Dis, 3, p. 377
Yang, Y., Herrup, K., (2005) J. Neurosci, 25, p. 2522
Love, S., (2003) Neurosci. Lett, 353, p. 29
Khurana, V., Lu, Y., Steinhilb, M.L., Oldham, S., Shulman, J.M., Feany, M.B., (2006) Curr. Biol, 16, p. 230
Rashidian, J., Iyirhiaro, G.O., Park, D.S., (2007) Biochim. Biophys. Acta, 1772, p. 484
Höglinger, G.U., Breunig, J.J., Depboylu, C., Rouaux, C., Michel, P.P., Alvarez-Fischer, D., Boutillier, A.L., Hunot, S., (2007) Proc. Natl. Acad. Sci. USA, 104, p. 3585
Copani, A., Uberti, D., Sortino, M.A., Bruno, V., Nicoletti, F., Memo, M., (2001) Trends Neurosci, 24, p. 25
Kruman, I.I., Schwartz, E.I., (2008) Front. Biosci, 13, p. 2504
Kruman, I.I. Cell Cycle, 2007, 6, 318Kruman, I.I., Wersto, R.P., Cardozo-Pelaez, F., Smilenov, L., Chan, S.L., Chrest, F.J., Emokpae Jr., R., Mattson, M.P., (2004) Neuron, 41, p. 549
Alvira, D., Yeste-Velasco, M., Folch, J., Casadesús, G., Smith, M.A., Pallàs, M., Camins, A., (2007) J. Neurosci. Res, 85, p. 3079
Solomon, B., (2007) Drugs Today, 43, p. 333
Forloni, G., Chiesa, R., Smiroldo, S., Verga, S., Salmona, M., Tagliavini, F., Angeretti, N., (1993) NeuroReport, 4, p. 523
Loo, D.T., Copani, A., Pike, C.J., Whittemore, E.R., Walencewicz, A.J., Cotman, C.W., (1993) Proc. Natl. Acad. Sci. USA, 90, p. 7951
LaFerla, F.M., Tinkle, B.T., Bieberich, C.J., Haudenschild, C.C., Jay, G., (1995) Nat. Genet, 9, p. 21
Su, J.H., Anderson, A.J., Cummings, B.J., Cotman, C.W., (1994) NeuroReport, 5, p. 2529
Copani, A., Condorelli, F., Caruso, A., Vancheri, C., Sala, A., Giuffrida Stella, A.M., Canonico, P.L., Sortino, M.A., (1999) FASEB J, 13, p. 2225
Copani, A., Melchiorri, D., Caricasole, A., Martini, F., Sale, P., Carnevale, R., Gradini, R., Nicoletti, F., (2002) J. Neurosci, 22, p. 3963
Giovanni, A., Wirtz-Brugger, F., Keramaris, E., Slack, R., Park, D.S., (1999) J. Biol. Chem, 274, p. 19011
Copani, A., Sortino, M.A., Caricasole, A., Chiechio, S., Chisari, M., Battaglia, G., Giuffrida-Stella, A.M., Nicoletti, F., (2006) FASEB J, 2002, p. 16
Rao, K.S., Annapurna, W., Raji, N.S., (2001) Ann. N. Y. Acad. Sci, 928, p. 113
Sugo, N., Aratani, Y., Nagashima, Y., Kubota, Y., Koyama, H., (2000) EMBO J, 19, p. 1397
Copani, A., Hoozemans, J.J., Caraci, F., Calafiore, M., Van Haastert, E.S., Veerhuis, R., Rozemuller, A.J., Nicoletti, F., (2006) J. Neurosci, 26, p. 10949
Malumbres, M., Pevarello, P., Barbacid, M., Bischoff, J.R., (2007) Trends Pharmacol. Sci, 29, p. 16
Verdaguer, E., Jorda, E.G., Stranges, A., Canudas, A.M., Jimenez, A., Sureda, F.X., Pallas, M., Camins, A., (2003) Ann. N. Y. Acad. Sci, 1010, p. 671
Verdaguer, E., Jimenez, A., Canudas, A.M., Jorda, E.G., Sureda, F.X., Pallas, M., Camins, A., (2004) J. Pharmacol. Exp. Ther, 308, p. 609
Giardina, S.F., Beart, P.M., (2002) Br. J. Pharmacol, 135, p. 1733
Katchanov, J., Harms, C., Gertz, K., Hauck, L., Waeber, C., Hirt, L., Priller, J., Endres, M., (2001) J. Neurosci, 21, p. 5045
Park, D.S. Proc. Natl. Acad. Sci. USA, 2000, 97, 10254Wang, F., Corbett, D., Osuga, H., Osuga, S., Ikeda, J.S., Slack, R.S., Hogan, M.J., Park, D.S., (2002) J. Cereb. Blood. Flow. Metab, 22, p. 171
Lopes, J.P., Oliveira, C.R., Agostinho, P., (2007) Cell. Mol. Neurobiol, 27, p. 943
Shridar, J., Akula, N., Pattabiraman, N., (2006) AAPS J, 8, pp. E204
Huse, M., Kuriyan, J., (2002) Cell, 109, p. 275
Adams, P.D., Li, X., Sellers, W.R., Baker, K.B., Leng, X., Harper, J.W., Taya, Y., Kaelin Jr., W.G., (1999) Mol. Cell. Biol, 19, p. 1068
Welburn, J.P.I., Endicott, J.A., (2005) Sem. Cell Devel. Biol, 16, p. 369
Knockaert, M., Greengard, P., Meijer, L., (2002) Trends Pharmacol. Sci, 23, p. 417
Wang, G., Miskimins, R., Miskimins, W.K., (2000) Exp. Cell Res, 254, p. 64
Perry, C., Sastry, R., Nasrallah, I.M., Stover, P.J., (2005) J. Biol. Chem, 280, p. 396
Ko, J., (2001) J. Neurosci, p. 6758
Li, G., Faibushevich, A., Turunen, B.J., Yoon, S.O., Georg, G., Michaelis, M.L., Dobrowsky, R.T., (2003) J. Neurochem, 84, p. 347
Patrick, G.N., Zukerberg, L., Nikolic, M., de la Monte, S., Dikkes, P., Tsai, L.H., (1999) Nature, 402, p. 615
Lee, M.S., (2000) Nature, 405, p. 360
Takashima, A., Honda, T., Yasutake, K., Michel, G., Murayama, O., Murayama, M., Ishiguro, K., Yamaguchi, H., (1998) Neurosci. Res, 31, p. 317
Fuentealba, R.A., Farias, G., Scheu, J., Bronfman, M., Marzolo, M.P., Inestrosa, N.C., (2004) Brain Res. Brain Res. Rev, 2004 (47), p. 275
Leroy, K., Yilmaz, Z., Brion, J.P., (2007) Neuropathol. Appl. Neurobiol, 33, p. 43
Caricasole, A., Copani, A., Caraci, F., Aronica, E., Rozemuller, A.J., Caruso, A., Storto, M., Nicoletti, F., (2004) J. Neurosci, 24, p. 6021
Sato, K. Proc. Natl. Acad. Sci. USA, 2003, 100, 6370Lu, W., Chen, L., Peng, Y., Chen, J., (2001) Oncogene, 20, p. 3206
Demidenko, Z.N., Blagosklonny, M.V., (2004) Cancer Res, 64, p. 3653
Benson, C., White, J., De Bono, J., O'Donnell, A., Raynaud, F., Cruickshank, C., McGrath, H., Twelves, C., (2007) Br. J. Cancer, 96, p. 29
Senderowicz, A.M., Headlee, D., Stinson, S.F., Lush, R.M., Kalil, N., Villalba, L., Hill, K., Sausville, E.A., (1998) J. Clin. Oncol, 16, p. 2986
Tan, A.R., Headlee, D., Messmann, R., Sausville, E.A., Arbuck, S.G., Murgo, A.J., Melillo, G., Senderowicz, A.M., (2002) J. Clin. Oncol, 20, p. 4074
Horton, J.K., Joyce-Gray, D.F., Pachkowski, B.F., Swenberg, J.A., Wilson, S.H., (2003) DNA Repair, 2, p. 27
Chen, J., Zhang, Y.-H., Wang, L.-K., Sucheck, S.J., Snow, A.M., Hecht, S.M., (1998) J. Chem. Soc. Chem. Commun, p. 2769
Deng, J.-Z., Sun, D.-A., Starck, S.R., Hecht, S.M., Cerny, R.L., Engen, J.R (1999) J. Chem. Soc. Perkin Trans, 1, p. 1147
Sun, D.A., Starck, S.R., Locke, E.P., Hecht, S.M (1999) J. Nat. Prod, 62, p. 1110
Mizushina, Y., Takahashi, N., Ogawa, A., Tsurugaya, K., Koshino, H., Takemura, M., Yoshida, S., Sakaguchi, K., (1999) J. Biochem, 126, p. 430
Deng, J.-Z., Starck, S.R., Hecht, S.M., (1999) J. Nat. Prod, 62, p. 477
Ogawa, A., Murate, T., Izuta, S., Takemura, M., Furuta, K., Kobayashi, J., Kamikawa, T., Yoshida, S., (1998) Int. J. Cancer, 76, p. 512
Mizushina, Y., Watanabe, I., Ohta, K., Takemura, M., Sahara, H., Takahashi, N., Gasa, S., Sakaguchi, K., (1998) Biochem. Pharmacol, 55, p. 537
Tanaka, N., Kitamura, A., Mizushina, Y., Sugawara, F., Sakaguchi, K., (1998) J. Nat. Prod, 61, p. 193
Mizushina, Y., Kamisuki, S., Kasai, N., Shimazaki, N., Takemura, M., Asahara, H., Linn, S., Sakaguchi, K., (2002) J. Biol. Chem, 277, p. 630
Perpelescu, M., Kobayashi, J., Furuta, M., Ito, Y., Izuta, S., Takemura, M., Suzuki, M., Yoshida, S., (2002) Biochemistry, 41, p. 7610
Kasai, N., Mizushina, Y., Sugawara, F., Sakaguchi, K., (2002) J. Biochem, 132, p. 819
Anderson, K.S., (2002) Biochim. Biophys. Acta, 1587, p. 296
Sawaya, M.R., Prasad, R., Wilson, S.H., Kraut, J., Pelletier, H., (1997) Biochemistry, 36, p. 11205
Hu, H.Y., Horton, J.K., Gryk, M.R., Prasad, R., Naron, J.M., Sun, D.A., Hecht, S.M., Mullen, G.P., (2004) J. Biol. Chem, 279, p. 39736
Moon, A.F., Garcia-Diaz, M., Batra, V.K., Beard, W.A., Bebenek, K., Kunkel, T.A., Wilson, S.H., Pedersen, L.C., (2007) DNA Repair, 6, p. 1709
Zerbe, L.K., Kuchta, R.D., (2002) Biochemistry, 41, p. 4891
Liu, D., Prasad, R., Wilson, H.W., DeRose, E.F., Mullen, G.P., (1996) Biochemistry, 35, p. 6188
Kirk, B.W., Kuchta, R.D., (1999) Biochemistry, 38, p. 7727
Mizushina, Y., Kasai, N., Miura, K., Hanashima, S., Takemura, M., Yoshida, H., Sugawara, F., Sakaguchi, K., (2004) Biochemistry, 43, p. 10669
Mizushina, Y., Ohkubo, T., Sugawara, F., Sakaguchi, K., (2000) Biochemistry, 39, p. 12606
Low, C.M.R., Vinter, J.G., (2008) J. Med. Chem, 51, p. 565
Irwi, J.J., Shoichet, B.K., (2004) J. Chem. Inf. Model, 45, p. 177
Thomsen, R., Christensen, M.H., (2006) J. Med. Chem, 49, p. 3315
Purushottamachar, P., Khandelwal, A., Chopra, P., Maheshwari, N., Gediya, L.K., Vasaitis, T.S., Bruno, R.D., Njar, V.C., (2007) Bioorg. Med. Chem, 15, p. 3413
Taha, M.O., Bustanji, Y., Al-Bakri, A.G., Yousef, A.-M., Zalloum, W.A., Al-Masri, I.M., Atallah, N., (2007) J. Mol. Graph. Model, 25, p. 870
Agrafiotis, D.K., Gibbs, A.C., Zhu, F., Izrailev, S., Martin, E., (2007) J. Chem. Inf. Model, 47, p. 1067
De Clercq, E., (2004) J. Clin. Virol, 30, p. 115
Gibbs, J.E., Thomas, S.A., (2002) J. Neurochem, 80, p. 392
Biade, S.R., Sobol, W., Wilson, S.H., Matsumoto, Y., (1998) J. Biol. Chem, 273, p. 898
Zhu, C. W., Sano, M., (2006) Clin. Interv. Aging, 1, p. 4
Selkoe, D. J., (2001) Physiol. Rev, 81, p. 741
Walsh, D. M., Selkoe, D. J., (2007) J. Neurochem, 101, p. 1172
Harbour, J. W., Luo, R. X., Del Santi, A., Postigo, A. A., Dean, D. C., (1999) Cell, 98, p. 859
Morgan, D. O., (1997) Annu. Rev. Cell Dev. Biol, 13, p. 261
Nigg, E. A., (1996) Curr. Opin. Cell Biol, 8, p. 312
Lee, M. H., Yang, H. Y., (2001) Cell. Mol. Life Sci, 58, p. 1907
Russo, A. A., Jeffery, P. D., Patten, A. K., Massagu, J., Pavletich, N. P., (1996) Nature, 382, p. 325
Ekholm, S. V., Reed, S. I., (2000) Curr. Opin. Cell Biol, 12, p. 676
el-Deiry, W. S., Tokino, T., Velculescu, V. E., Levy, D. B., Parsons, R., Trent, J. M., Lin, D., Vogelstein, B., (1993) Cell, 75, p. 817
Vousden, K. H., Lu, X., (2002) Nat. Rev. Cancer, 2, p. 594
Kastan, M. B., Lim, D. S., (2000) Nat. Rev. Mol. Cell Biol, 1, p. 179
Friedberg, E. C., (2006) Nat. Rev. Mol. Cell Biol, 2, p. 143
Burgers, P. M., (1998) Chromosoma, 107, p. 218
Kelly, T. J., Brown, G. W., (2000) Annu. Rev. Biochem, 68, p. 829
Bell, S. P., Dutta, A., (2002) Annu. Rev. Biochem, 71, p. 333
Dhar, S. K., Delmolino, L., Dutta, A., (2001) J. Biol. Chem, 276, p. 29067
Michael, W. M., Ott, R., Fanning, E., Newport, J., (2000) Science, 289, p. 2133
Piersen, C. E., Prasad, R., Wilson, S. H., Lloyd, R. S., (1996) J. Biol. Chem, 271, p. 17811
Friedberg, E. C., Wagner, R., Radman, M., (2002) Science, 296, p. 1627
Srivastava, D. K., Husain, I., Arteaga, C. L., Wilson, S. H., (1999) Carcinogenesis, 20, p. 1049
and Wilson, S. H. Nucleic Acids Res., 1988, 16, 9589Sweasy, J., Loeb, L., (1992) J. Biol. Chem, 267, p. 1407
Siegel, R. L., Kalf, G. F., (1982) J. Biol. Chem, 257, p. 1785
Smith, M. A. Am. J. Pathol., 1997, 150, 1933Arendt, T., Holzer, M., Gartner, U., Bruckner, M. K., (1998) J. Neural. Transm. Suppl, 54, p. 147
Bennet, D. A., Wilson, R. S., Schneider, J. A., Evans, D. A., Beckett, L. A., Aggarwal, N. T., Barnes, L. L., Bach, J., (2002) Neurology, 59, p. 198
Paudel, H. K., Lew, J., Ali, Z., Wang, J. H., (1993) J. Biol. Chem, 268, p. 23512
Pei, J. J., Braak, H., Gong, C. X., Grundke-Iqbal, I., Iqbal, K., Winblad, B., Cowburn, R. F., (2002) Acta Neuropathol, 104, p. 369
Hock Jr., B. J., Lamb, B. T., (2001) Trends Genet, 17, pp. S7
Teng, F. Y. H., Tang, B. L., (2005) Cell. Mol. Life Sci, 62, p. 1571
Lee, S. S., Kim, Y. M., Junn, E., Lee, G., Park, H. K., Tanaka, M., Ronchetti, R. D., Mouradian, M. M., (2003) Neurobiol. Aging, 24, p. 687
Husseman, J. W., Nochlin, D., Vincent, I., (2000) Neurobiol. Aging, 21, p. 815
H glinger, G. U., Breunig, J. J., Depboylu, C., Rouaux, C., Michel, P. P., Alvarez-Fischer, D., Boutillier, A. L., Hunot, S., (2007) Proc. Natl. Acad. Sci. USA, 104, p. 3585
Kruman, I. I., Schwartz, E. I., (2008) Front. Biosci, 13, p. 2504
Kruman, I. I. Cell Cycle, 2007, 6, 318Kruman, I. I., Wersto, R. P., Cardozo-Pelaez, F., Smilenov, L., Chan, S. L., Chrest, F. J., Emokpae Jr., R., Mattson, M. P., (2004) Neuron, 41, p. 549
Loo, D. T., Copani, A., Pike, C. J., Whittemore, E. R., Walencewicz, A. J., Cotman, C. W., (1993) Proc. Natl. Acad. Sci. USA, 90, p. 7951
LaFerla, F. M., Tinkle, B. T., Bieberich, C. J., Haudenschild, C. C., Jay, G., (1995) Nat. Genet, 9, p. 21
Su, J. H., Anderson, A. J., Cummings, B. J., Cotman, C. W., (1994) NeuroReport, 5, p. 2529
Rao, K. S., Annapurna, W., Raji, N. S., (2001) Ann. N. Y. Acad. Sci, 928, p. 113
Giardina, S. F., Beart, P. M., (2002) Br. J. Pharmacol, 135, p. 1733
Park, D. S. Proc. Natl. Acad. Sci. USA, 2000, 97, 10254Wang, F., Corbett, D., Osuga, H., Osuga, S., Ikeda, J. S., Slack, R. S., Hogan, M. J., Park, D. S., (2002) J. Cereb. Blood. Flow. Metab, 22, p. 171
Lopes, J. P., Oliveira, C. R., Agostinho, P., (2007) Cell. Mol. Neurobiol, 27, p. 943
Adams, P. D., Li, X., Sellers, W. R., Baker, K. B., Leng, X., Harper, J. W., Taya, Y., Kaelin Jr., W. G., (1999) Mol. Cell. Biol, 19, p. 1068
Welburn, J. P. I., Endicott, J. A., (2005) Sem. Cell Devel. Biol, 16, p. 369
Patrick, G. N., Zukerberg, L., Nikolic, M., de la Monte, S., Dikkes, P., Tsai, L. H., (1999) Nature, 402, p. 615
Lee, M. S., (2000) Nature, 405, p. 360
Fuentealba, R. A., Farias, G., Scheu, J., Bronfman, M., Marzolo, M. P., Inestrosa, N. C., (2004) Brain Res. Brain Res. Rev, 2004 (47), p. 275
Demidenko, Z. N., Blagosklonny, M. V., (2004) Cancer Res, 64, p. 3653
Senderowicz, A. M., Headlee, D., Stinson, S. F., Lush, R. M., Kalil, N., Villalba, L., Hill, K., Sausville, E. A., (1998) J. Clin. Oncol, 16, p. 2986
Tan, A. R., Headlee, D., Messmann, R., Sausville, E. A., Arbuck, S. G., Murgo, A. J., Melillo, G., Senderowicz, A. M., (2002) J. Clin. Oncol, 20, p. 4074
Horton, J. K., Joyce-Gray, D. F., Pachkowski, B. F., Swenberg, J. A., Wilson, S. H., (2003) DNA Repair, 2, p. 27
Deng, J. -Z., Sun, D. -A., Starck, S. R., Hecht, S. M., Cerny, R. L., Engen, J. R (1999) J. Chem. Soc. Perkin Trans, 1, p. 1147
Sun, D. A., Starck, S. R., Locke, E. P., Hecht, S. M (1999) J. Nat. Prod, 62, p. 1110
Deng, J. -Z., Starck, S. R., Hecht, S. M., (1999) J. Nat. Prod, 62, p. 477
Anderson, K. S., (2002) Biochim. Biophys. Acta, 1587, p. 296
Sawaya, M. R., Prasad, R., Wilson, S. H., Kraut, J., Pelletier, H., (1997) Biochemistry, 36, p. 11205
Hu, H. Y., Horton, J. K., Gryk, M. R., Prasad, R., Naron, J. M., Sun, D. A., Hecht, S. M., Mullen, G. P., (2004) J. Biol. Chem, 279, p. 39736
Moon, A. F., Garcia-Diaz, M., Batra, V. K., Beard, W. A., Bebenek, K., Kunkel, T. A., Wilson, S. H., Pedersen, L. C., (2007) DNA Repair, 6, p. 1709
Zerbe, L. K., Kuchta, R. D., (2002) Biochemistry, 41, p. 4891
Kirk, B. W., Kuchta, R. D., (1999) Biochemistry, 38, p. 7727
Low, C. M. R., Vinter, J. G., (2008) J. Med. Chem, 51, p. 565
Irwi, J. J., Shoichet, B. K., (2004) J. Chem. Inf. Model, 45, p. 177
Taha, M. O., Bustanji, Y., Al-Bakri, A. G., Yousef, A. -M., Zalloum, W. A., Al-Masri, I. M., Atallah, N., (2007) J. Mol. Graph. Model, 25, p. 870
Agrafiotis, D. K., Gibbs, A. C., Zhu, F., Izrailev, S., Martin, E., (2007) J. Chem. Inf. Model, 47, p. 1067
Gibbs, J. E., Thomas, S. A., (2002) J. Neurochem, 80, p. 392
Biade, S. R., Sobol, W., Wilson, S. H., Matsumoto, Y., (1998) J. Biol. Chem, 273, p. 898
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2008; 15(24): 2420-2432.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 4.823, 5-year impact factor: 5.291
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-55249091338&partnerID=40&md5=55dc351fc333115ed6dbdf77e3158e24
Keywords: β-Amyloid, Alzheimer, S Disease, Apoptosis, Cell Cycle, Cyclin-Dependent Kinases, Dna Polymerase-β, Dna Replication, Neuroprotection, Amyloid Beta Protein, Cyclin Dependent Kinase 1, Cyclin Dependent Kinase Inhibitor, Dna Directed Dna Polymerase Beta, Flavopiridol, Mimosine, Olomoucine, Protein P53, Roscovitine, Zalcitabine, Neuroprotective Agent, Alzheimer Disease, Binding Site, Cell Cycle Arrest, Cell Cycle G1 Phase, Cell Cycle Progression, Cell Cycle S Phase, Cell Proliferation, Clinical Trial, Creatinine Blood Level, Diarrhea, Dna Repair, Dna Synthesis, Drug Efficacy, Drug Eruption, Drug Potency, Drug Selectivity, Drug Structure, Drug Targeting, Gene Activation, Gene Mutation, Gene Targeting, Human, Nausea, Nerve Degeneration, Neurofibrillary Tangle, Nonhuman, Pathogenesis, Review, Side Effect, Vomiting, Animal, Biological Model, Drug Effect, Drug Screening, Metabolism, Pathology, Drug Evaluation, Preclinical, Neurological,
Affiliations:
*** IBB - CNR ***
Department of Pharmaceutical Sciences, University of Catania, Viale A. Doria 6, 95125 Catania, Italy
I.B.B., CNR-Catania, Catania, Italy
Department of Experimental and Clinical Pharmacology, University of Catania, Viale A. Doria 6, 95125 Catania, Italy
Department of Human Physiology and Pharmacology, University of Rome La Sapienza, Italy
I.N.M. Neuromed, Pozzilli, Italy
I. B. B., CNR-Catania, Catania, Italy
I. N. M. Neuromed, Pozzilli, Italy
References:
Zhu, C.W., Sano, M., (2006) Clin. Interv. Aging, 1, p. 4
Loveman, E., Green, C., Kirby, J., Takeda, A., Picot, J., Payne, E., Clegg, A., (2006) Health Technol. Assess, 10, p. 1
Katzman, K., (1986) N. Engl. J. Med, 314, p. 964
Selkoe, D.J., (2001) Physiol. Rev, 81, p. 741
Walsh, D.M., Selkoe, D.J., (2007) J. Neurochem, 101, p. 1172
Blurton-Jones, M., Laferla, F.M., (2006) Curr. Alzheimer Res, 5, p. 437
Herrup, K., Neve, R., Ackerman, S.L., Copani, A., (2004) J. Neurosci, 24, p. 9232
Van Den Heuvel, S., Harlow, E., (1993) Science, 262, p. 2050
Harbour, J.W., Luo, R.X., Del Santi, A., Postigo, A.A., Dean, D.C., (1999) Cell, 98, p. 859
Ren, S., Rollins, B.J., (2004) Cell, 117, p. 239
Morgan, D.O., (1997) Annu. Rev. Cell Dev. Biol, 13, p. 261
Nigg, E.A., (1996) Curr. Opin. Cell Biol, 8, p. 312
Lee, M.H., Yang, H.Y., (2001) Cell. Mol. Life Sci, 58, p. 1907
Russo, A.A., Jeffery, P.D., Patten, A.K., Massagué, J., Pavletich, N.P., (1996) Nature, 382, p. 325
Ekholm, S.V., Reed, S.I., (2000) Curr. Opin. Cell Biol, 12, p. 676
Malumbres, M., Barbacid, M., (2001) Nat. Rev. Cancer, 1, p. 222
el-Deiry, W.S., Tokino, T., Velculescu, V.E., Levy, D.B., Parsons, R., Trent, J.M., Lin, D., Vogelstein, B., (1993) Cell, 75, p. 817
Haupt, S., Berger, M., Goldberg, Z., Haupt, Y., (2003) J. Cell Sci, 116, p. 4077
Haupt, S., Haupt, Y., (2006) Anticancer Drugs, 17, p. 725
Vousden, K.H., Lu, X., (2002) Nat. Rev. Cancer, 2, p. 594
Kastan, M.B., Lim, D.S., (2000) Nat. Rev. Mol. Cell Biol, 1, p. 179
Niida, H., Nakanishi, M., (2006) Mutagenesis, 21, p. 3
Liu, Q., Guntuku, S., Cui, X.S., Matsuoka, S., Cortez, D., Tamai, K., Luo, G., Elledge, S.J., (2000) Genes Dev, 14, p. 1448
Pommier, Y., Sordet, O., Rao, V.A., Zhang, H., Kohn, K.W., (2005) Curr. Pharm. Des, 11, p. 2855
Hubscher, U., Nasheuer, H.P., Syvaoia, J.E., (2000) Trends Biochem. Sci, 25, p. 143
Arezi, B., Kuchta, R.D., (2000) Trends Biochem. Sci, 25, p. 572
Friedberg, E.C., (2006) Nat. Rev. Mol. Cell Biol, 2, p. 143
Burgers, P.M., (1998) Chromosoma, 107, p. 218
Kelly, T.J., Brown, G.W., (2000) Annu. Rev. Biochem, 68, p. 829
Bell, S.P., Dutta, A., (2002) Annu. Rev. Biochem, 71, p. 333
Dhar, S.K., Delmolino, L., Dutta, A., (2001) J. Biol. Chem, 276, p. 29067
Tsurimoto, T., Stillman, B., (1991) J. Biol. Chem, 266, p. 1961
Michael, W.M., Ott, R., Fanning, E., Newport, J., (2000) Science, 289, p. 2133
Dantzer, F., Nasheuer, H.P., Vonesch, J.L., de Murcia, G., Ménissier-de Murcia, J., (1998) Nucleic Acids Res, 26, p. 1891
Kelman, Z., (1997) Oncogene, 14, p. 629
Holmes, J., Clark, S., Modrich, P., (1990) Proc. Natl. Acad. Sci. USA, 87, p. 5837
Stucki, M., Pascucci, B., Parlanti, E., Fortini, P., Wilson, S.H., Hubscher, U., Dogliotti, E., (1998) Oncogene, 17, p. 835
Sobol, R., Horton, J., Kuhn, R., Gu, H., Prasad, R., Rajewsky, K., Wilson, S.H., (1996) Nature, 379, p. 183
Matsumoto, Y., Kim, K., (1995) Science, 269, p. 699
Piersen, C.E., Prasad, R., Wilson, S.H., Lloyd, R.S., (1996) J. Biol. Chem, 271, p. 17811
Pelletier, H., Sawaya, M.R., Kumar, A., Wilson, S.H., Kraut, J., (1994) Science, 264, p. 1891
Kunkel, T., (1985) J. Biol. Chem, 260, p. 5787
Friedberg, E.C., Wagner, R., Radman, M., (2002) Science, 296, p. 1627
Canitrot, Y., Frechet, M., Servant, L., Cazaux, C., Hoffmann, J.S., (1999) FASEB J, 13, p. 1107
Canitrot, Y., Cazaux, C., Frechet, M., Bouayadi, K., Lesca, C., Salles, B., Hoffmann, J.S., (1998) Proc. Natl. Acad. Sci. USA, 95, p. 12586
Servant, L., Bieth, A., Hayakawa, H., Cazaux, C., Hoffmann, J.-S., (2002) J. Mol. Biol, 315, p. 1039
Canitrot, Y., Hoffmann, J.S., Calsou, P., Hayakawa, H., Salles, B., Cazaux, C., (2000) FASEB J, 14, p. 1765
Srivastava, D.K., Husain, I., Arteaga, C.L., Wilson, S.H., (1999) Carcinogenesis, 20, p. 1049
and Wilson, S.H. Nucleic Acids Res., 1988, 16, 9589Sweasy, J., Loeb, L., (1992) J. Biol. Chem, 267, p. 1407
Siegel, R.L., Kalf, G.F., (1982) J. Biol. Chem, 257, p. 1785
Vincent, I., Rosado, M., Davies, P., (1996) J. Cell Biol, 132, p. 413
Busser, J., Geldmacher, D.S., Herrup, K., (1998) J. Neurosci, 18, p. 2801
Nagy, Z., Esiri, M.M., Smith, A.D., (1997) Acta Neuropathol, 93, p. 294
Smith, M.A. Am. J. Pathol., 1997, 150, 1933Arendt, T., Holzer, M., Gartner, U., Bruckner, M.K., (1998) J. Neural. Transm. Suppl, 54, p. 147
Yang, Y., Mufson, E.J., Herrup, K., (2003) J. Neurosci, 23, p. 2557
Bennet, D.A., Wilson, R.S., Schneider, J.A., Evans, D.A., Beckett, L.A., Aggarwal, N.T., Barnes, L.L., Bach, J., (2002) Neurology, 59, p. 198
Yang, Y., Geldmacher, D.S., Herrup, K., (2001) J. Neurosci, 21, p. 2661
Dranovsky, A., Vincent, I., Gregori, L., Schwarzman, A., Colflesh, D., Enghild, J., Strittmatter, W., Goldgaber, D., (2001) Neurobiol. Aging, 22, p. 517
Paudel, H.K., Lew, J., Ali, Z., Wang, J.H., (1993) J. Biol. Chem, 268, p. 23512
Pei, J.J., Braak, H., Gong, C.X., Grundke-Iqbal, I., Iqbal, K., Winblad, B., Cowburn, R.F., (2002) Acta Neuropathol, 104, p. 369
Yang, Y., Varvel, N.H., Lamb, B.T., Herrup, K., (2006) J. Neurosci, 26, p. 775
Hock Jr., B.J., Lamb, B.T., (2001) Trends Genet, 17, pp. S7
Ueberham, U., Arendt, T., (2005) Curr. Drug Targets CNS Neurol. Disord, 4, p. 293
Huang, Z., Zang, K., Reichardt, L.F., (2005) J. Cell Biol, 170, p. 527
Teng, F.Y.H., Tang, B.L., (2005) Cell. Mol. Life Sci, 62, p. 1571
Lee, S.S., Kim, Y.M., Junn, E., Lee, G., Park, H.K., Tanaka, M., Ronchetti, R.D., Mouradian, M.M., (2003) Neurobiol. Aging, 24, p. 687
Husseman, J.W., Nochlin, D., Vincent, I., (2000) Neurobiol. Aging, 21, p. 815
Ranganathan, S., Scudiere, S., Bowser, R.J., (2001) Alzheimer's Dis, 3, p. 377
Yang, Y., Herrup, K., (2005) J. Neurosci, 25, p. 2522
Love, S., (2003) Neurosci. Lett, 353, p. 29
Khurana, V., Lu, Y., Steinhilb, M.L., Oldham, S., Shulman, J.M., Feany, M.B., (2006) Curr. Biol, 16, p. 230
Rashidian, J., Iyirhiaro, G.O., Park, D.S., (2007) Biochim. Biophys. Acta, 1772, p. 484
Höglinger, G.U., Breunig, J.J., Depboylu, C., Rouaux, C., Michel, P.P., Alvarez-Fischer, D., Boutillier, A.L., Hunot, S., (2007) Proc. Natl. Acad. Sci. USA, 104, p. 3585
Copani, A., Uberti, D., Sortino, M.A., Bruno, V., Nicoletti, F., Memo, M., (2001) Trends Neurosci, 24, p. 25
Kruman, I.I., Schwartz, E.I., (2008) Front. Biosci, 13, p. 2504
Kruman, I.I. Cell Cycle, 2007, 6, 318Kruman, I.I., Wersto, R.P., Cardozo-Pelaez, F., Smilenov, L., Chan, S.L., Chrest, F.J., Emokpae Jr., R., Mattson, M.P., (2004) Neuron, 41, p. 549
Alvira, D., Yeste-Velasco, M., Folch, J., Casadesús, G., Smith, M.A., Pallàs, M., Camins, A., (2007) J. Neurosci. Res, 85, p. 3079
Solomon, B., (2007) Drugs Today, 43, p. 333
Forloni, G., Chiesa, R., Smiroldo, S., Verga, S., Salmona, M., Tagliavini, F., Angeretti, N., (1993) NeuroReport, 4, p. 523
Loo, D.T., Copani, A., Pike, C.J., Whittemore, E.R., Walencewicz, A.J., Cotman, C.W., (1993) Proc. Natl. Acad. Sci. USA, 90, p. 7951
LaFerla, F.M., Tinkle, B.T., Bieberich, C.J., Haudenschild, C.C., Jay, G., (1995) Nat. Genet, 9, p. 21
Su, J.H., Anderson, A.J., Cummings, B.J., Cotman, C.W., (1994) NeuroReport, 5, p. 2529
Copani, A., Condorelli, F., Caruso, A., Vancheri, C., Sala, A., Giuffrida Stella, A.M., Canonico, P.L., Sortino, M.A., (1999) FASEB J, 13, p. 2225
Copani, A., Melchiorri, D., Caricasole, A., Martini, F., Sale, P., Carnevale, R., Gradini, R., Nicoletti, F., (2002) J. Neurosci, 22, p. 3963
Giovanni, A., Wirtz-Brugger, F., Keramaris, E., Slack, R., Park, D.S., (1999) J. Biol. Chem, 274, p. 19011
Copani, A., Sortino, M.A., Caricasole, A., Chiechio, S., Chisari, M., Battaglia, G., Giuffrida-Stella, A.M., Nicoletti, F., (2006) FASEB J, 2002, p. 16
Rao, K.S., Annapurna, W., Raji, N.S., (2001) Ann. N. Y. Acad. Sci, 928, p. 113
Sugo, N., Aratani, Y., Nagashima, Y., Kubota, Y., Koyama, H., (2000) EMBO J, 19, p. 1397
Copani, A., Hoozemans, J.J., Caraci, F., Calafiore, M., Van Haastert, E.S., Veerhuis, R., Rozemuller, A.J., Nicoletti, F., (2006) J. Neurosci, 26, p. 10949
Malumbres, M., Pevarello, P., Barbacid, M., Bischoff, J.R., (2007) Trends Pharmacol. Sci, 29, p. 16
Verdaguer, E., Jorda, E.G., Stranges, A., Canudas, A.M., Jimenez, A., Sureda, F.X., Pallas, M., Camins, A., (2003) Ann. N. Y. Acad. Sci, 1010, p. 671
Verdaguer, E., Jimenez, A., Canudas, A.M., Jorda, E.G., Sureda, F.X., Pallas, M., Camins, A., (2004) J. Pharmacol. Exp. Ther, 308, p. 609
Giardina, S.F., Beart, P.M., (2002) Br. J. Pharmacol, 135, p. 1733
Katchanov, J., Harms, C., Gertz, K., Hauck, L., Waeber, C., Hirt, L., Priller, J., Endres, M., (2001) J. Neurosci, 21, p. 5045
Park, D.S. Proc. Natl. Acad. Sci. USA, 2000, 97, 10254Wang, F., Corbett, D., Osuga, H., Osuga, S., Ikeda, J.S., Slack, R.S., Hogan, M.J., Park, D.S., (2002) J. Cereb. Blood. Flow. Metab, 22, p. 171
Lopes, J.P., Oliveira, C.R., Agostinho, P., (2007) Cell. Mol. Neurobiol, 27, p. 943
Shridar, J., Akula, N., Pattabiraman, N., (2006) AAPS J, 8, pp. E204
Huse, M., Kuriyan, J., (2002) Cell, 109, p. 275
Adams, P.D., Li, X., Sellers, W.R., Baker, K.B., Leng, X., Harper, J.W., Taya, Y., Kaelin Jr., W.G., (1999) Mol. Cell. Biol, 19, p. 1068
Welburn, J.P.I., Endicott, J.A., (2005) Sem. Cell Devel. Biol, 16, p. 369
Knockaert, M., Greengard, P., Meijer, L., (2002) Trends Pharmacol. Sci, 23, p. 417
Wang, G., Miskimins, R., Miskimins, W.K., (2000) Exp. Cell Res, 254, p. 64
Perry, C., Sastry, R., Nasrallah, I.M., Stover, P.J., (2005) J. Biol. Chem, 280, p. 396
Ko, J., (2001) J. Neurosci, p. 6758
Li, G., Faibushevich, A., Turunen, B.J., Yoon, S.O., Georg, G., Michaelis, M.L., Dobrowsky, R.T., (2003) J. Neurochem, 84, p. 347
Patrick, G.N., Zukerberg, L., Nikolic, M., de la Monte, S., Dikkes, P., Tsai, L.H., (1999) Nature, 402, p. 615
Lee, M.S., (2000) Nature, 405, p. 360
Takashima, A., Honda, T., Yasutake, K., Michel, G., Murayama, O., Murayama, M., Ishiguro, K., Yamaguchi, H., (1998) Neurosci. Res, 31, p. 317
Fuentealba, R.A., Farias, G., Scheu, J., Bronfman, M., Marzolo, M.P., Inestrosa, N.C., (2004) Brain Res. Brain Res. Rev, 2004 (47), p. 275
Leroy, K., Yilmaz, Z., Brion, J.P., (2007) Neuropathol. Appl. Neurobiol, 33, p. 43
Caricasole, A., Copani, A., Caraci, F., Aronica, E., Rozemuller, A.J., Caruso, A., Storto, M., Nicoletti, F., (2004) J. Neurosci, 24, p. 6021
Sato, K. Proc. Natl. Acad. Sci. USA, 2003, 100, 6370Lu, W., Chen, L., Peng, Y., Chen, J., (2001) Oncogene, 20, p. 3206
Demidenko, Z.N., Blagosklonny, M.V., (2004) Cancer Res, 64, p. 3653
Benson, C., White, J., De Bono, J., O'Donnell, A., Raynaud, F., Cruickshank, C., McGrath, H., Twelves, C., (2007) Br. J. Cancer, 96, p. 29
Senderowicz, A.M., Headlee, D., Stinson, S.F., Lush, R.M., Kalil, N., Villalba, L., Hill, K., Sausville, E.A., (1998) J. Clin. Oncol, 16, p. 2986
Tan, A.R., Headlee, D., Messmann, R., Sausville, E.A., Arbuck, S.G., Murgo, A.J., Melillo, G., Senderowicz, A.M., (2002) J. Clin. Oncol, 20, p. 4074
Horton, J.K., Joyce-Gray, D.F., Pachkowski, B.F., Swenberg, J.A., Wilson, S.H., (2003) DNA Repair, 2, p. 27
Chen, J., Zhang, Y.-H., Wang, L.-K., Sucheck, S.J., Snow, A.M., Hecht, S.M., (1998) J. Chem. Soc. Chem. Commun, p. 2769
Deng, J.-Z., Sun, D.-A., Starck, S.R., Hecht, S.M., Cerny, R.L., Engen, J.R (1999) J. Chem. Soc. Perkin Trans, 1, p. 1147
Sun, D.A., Starck, S.R., Locke, E.P., Hecht, S.M (1999) J. Nat. Prod, 62, p. 1110
Mizushina, Y., Takahashi, N., Ogawa, A., Tsurugaya, K., Koshino, H., Takemura, M., Yoshida, S., Sakaguchi, K., (1999) J. Biochem, 126, p. 430
Deng, J.-Z., Starck, S.R., Hecht, S.M., (1999) J. Nat. Prod, 62, p. 477
Ogawa, A., Murate, T., Izuta, S., Takemura, M., Furuta, K., Kobayashi, J., Kamikawa, T., Yoshida, S., (1998) Int. J. Cancer, 76, p. 512
Mizushina, Y., Watanabe, I., Ohta, K., Takemura, M., Sahara, H., Takahashi, N., Gasa, S., Sakaguchi, K., (1998) Biochem. Pharmacol, 55, p. 537
Tanaka, N., Kitamura, A., Mizushina, Y., Sugawara, F., Sakaguchi, K., (1998) J. Nat. Prod, 61, p. 193
Mizushina, Y., Kamisuki, S., Kasai, N., Shimazaki, N., Takemura, M., Asahara, H., Linn, S., Sakaguchi, K., (2002) J. Biol. Chem, 277, p. 630
Perpelescu, M., Kobayashi, J., Furuta, M., Ito, Y., Izuta, S., Takemura, M., Suzuki, M., Yoshida, S., (2002) Biochemistry, 41, p. 7610
Kasai, N., Mizushina, Y., Sugawara, F., Sakaguchi, K., (2002) J. Biochem, 132, p. 819
Anderson, K.S., (2002) Biochim. Biophys. Acta, 1587, p. 296
Sawaya, M.R., Prasad, R., Wilson, S.H., Kraut, J., Pelletier, H., (1997) Biochemistry, 36, p. 11205
Hu, H.Y., Horton, J.K., Gryk, M.R., Prasad, R., Naron, J.M., Sun, D.A., Hecht, S.M., Mullen, G.P., (2004) J. Biol. Chem, 279, p. 39736
Moon, A.F., Garcia-Diaz, M., Batra, V.K., Beard, W.A., Bebenek, K., Kunkel, T.A., Wilson, S.H., Pedersen, L.C., (2007) DNA Repair, 6, p. 1709
Zerbe, L.K., Kuchta, R.D., (2002) Biochemistry, 41, p. 4891
Liu, D., Prasad, R., Wilson, H.W., DeRose, E.F., Mullen, G.P., (1996) Biochemistry, 35, p. 6188
Kirk, B.W., Kuchta, R.D., (1999) Biochemistry, 38, p. 7727
Mizushina, Y., Kasai, N., Miura, K., Hanashima, S., Takemura, M., Yoshida, H., Sugawara, F., Sakaguchi, K., (2004) Biochemistry, 43, p. 10669
Mizushina, Y., Ohkubo, T., Sugawara, F., Sakaguchi, K., (2000) Biochemistry, 39, p. 12606
Low, C.M.R., Vinter, J.G., (2008) J. Med. Chem, 51, p. 565
Irwi, J.J., Shoichet, B.K., (2004) J. Chem. Inf. Model, 45, p. 177
Thomsen, R., Christensen, M.H., (2006) J. Med. Chem, 49, p. 3315
Purushottamachar, P., Khandelwal, A., Chopra, P., Maheshwari, N., Gediya, L.K., Vasaitis, T.S., Bruno, R.D., Njar, V.C., (2007) Bioorg. Med. Chem, 15, p. 3413
Taha, M.O., Bustanji, Y., Al-Bakri, A.G., Yousef, A.-M., Zalloum, W.A., Al-Masri, I.M., Atallah, N., (2007) J. Mol. Graph. Model, 25, p. 870
Agrafiotis, D.K., Gibbs, A.C., Zhu, F., Izrailev, S., Martin, E., (2007) J. Chem. Inf. Model, 47, p. 1067
De Clercq, E., (2004) J. Clin. Virol, 30, p. 115
Gibbs, J.E., Thomas, S.A., (2002) J. Neurochem, 80, p. 392
Biade, S.R., Sobol, W., Wilson, S.H., Matsumoto, Y., (1998) J. Biol. Chem, 273, p. 898
Zhu, C. W., Sano, M., (2006) Clin. Interv. Aging, 1, p. 4
Selkoe, D. J., (2001) Physiol. Rev, 81, p. 741
Walsh, D. M., Selkoe, D. J., (2007) J. Neurochem, 101, p. 1172
Harbour, J. W., Luo, R. X., Del Santi, A., Postigo, A. A., Dean, D. C., (1999) Cell, 98, p. 859
Morgan, D. O., (1997) Annu. Rev. Cell Dev. Biol, 13, p. 261
Nigg, E. A., (1996) Curr. Opin. Cell Biol, 8, p. 312
Lee, M. H., Yang, H. Y., (2001) Cell. Mol. Life Sci, 58, p. 1907
Russo, A. A., Jeffery, P. D., Patten, A. K., Massagu, J., Pavletich, N. P., (1996) Nature, 382, p. 325
Ekholm, S. V., Reed, S. I., (2000) Curr. Opin. Cell Biol, 12, p. 676
el-Deiry, W. S., Tokino, T., Velculescu, V. E., Levy, D. B., Parsons, R., Trent, J. M., Lin, D., Vogelstein, B., (1993) Cell, 75, p. 817
Vousden, K. H., Lu, X., (2002) Nat. Rev. Cancer, 2, p. 594
Kastan, M. B., Lim, D. S., (2000) Nat. Rev. Mol. Cell Biol, 1, p. 179
Friedberg, E. C., (2006) Nat. Rev. Mol. Cell Biol, 2, p. 143
Burgers, P. M., (1998) Chromosoma, 107, p. 218
Kelly, T. J., Brown, G. W., (2000) Annu. Rev. Biochem, 68, p. 829
Bell, S. P., Dutta, A., (2002) Annu. Rev. Biochem, 71, p. 333
Dhar, S. K., Delmolino, L., Dutta, A., (2001) J. Biol. Chem, 276, p. 29067
Michael, W. M., Ott, R., Fanning, E., Newport, J., (2000) Science, 289, p. 2133
Piersen, C. E., Prasad, R., Wilson, S. H., Lloyd, R. S., (1996) J. Biol. Chem, 271, p. 17811
Friedberg, E. C., Wagner, R., Radman, M., (2002) Science, 296, p. 1627
Srivastava, D. K., Husain, I., Arteaga, C. L., Wilson, S. H., (1999) Carcinogenesis, 20, p. 1049
and Wilson, S. H. Nucleic Acids Res., 1988, 16, 9589Sweasy, J., Loeb, L., (1992) J. Biol. Chem, 267, p. 1407
Siegel, R. L., Kalf, G. F., (1982) J. Biol. Chem, 257, p. 1785
Smith, M. A. Am. J. Pathol., 1997, 150, 1933Arendt, T., Holzer, M., Gartner, U., Bruckner, M. K., (1998) J. Neural. Transm. Suppl, 54, p. 147
Bennet, D. A., Wilson, R. S., Schneider, J. A., Evans, D. A., Beckett, L. A., Aggarwal, N. T., Barnes, L. L., Bach, J., (2002) Neurology, 59, p. 198
Paudel, H. K., Lew, J., Ali, Z., Wang, J. H., (1993) J. Biol. Chem, 268, p. 23512
Pei, J. J., Braak, H., Gong, C. X., Grundke-Iqbal, I., Iqbal, K., Winblad, B., Cowburn, R. F., (2002) Acta Neuropathol, 104, p. 369
Hock Jr., B. J., Lamb, B. T., (2001) Trends Genet, 17, pp. S7
Teng, F. Y. H., Tang, B. L., (2005) Cell. Mol. Life Sci, 62, p. 1571
Lee, S. S., Kim, Y. M., Junn, E., Lee, G., Park, H. K., Tanaka, M., Ronchetti, R. D., Mouradian, M. M., (2003) Neurobiol. Aging, 24, p. 687
Husseman, J. W., Nochlin, D., Vincent, I., (2000) Neurobiol. Aging, 21, p. 815
H glinger, G. U., Breunig, J. J., Depboylu, C., Rouaux, C., Michel, P. P., Alvarez-Fischer, D., Boutillier, A. L., Hunot, S., (2007) Proc. Natl. Acad. Sci. USA, 104, p. 3585
Kruman, I. I., Schwartz, E. I., (2008) Front. Biosci, 13, p. 2504
Kruman, I. I. Cell Cycle, 2007, 6, 318Kruman, I. I., Wersto, R. P., Cardozo-Pelaez, F., Smilenov, L., Chan, S. L., Chrest, F. J., Emokpae Jr., R., Mattson, M. P., (2004) Neuron, 41, p. 549
Loo, D. T., Copani, A., Pike, C. J., Whittemore, E. R., Walencewicz, A. J., Cotman, C. W., (1993) Proc. Natl. Acad. Sci. USA, 90, p. 7951
LaFerla, F. M., Tinkle, B. T., Bieberich, C. J., Haudenschild, C. C., Jay, G., (1995) Nat. Genet, 9, p. 21
Su, J. H., Anderson, A. J., Cummings, B. J., Cotman, C. W., (1994) NeuroReport, 5, p. 2529
Rao, K. S., Annapurna, W., Raji, N. S., (2001) Ann. N. Y. Acad. Sci, 928, p. 113
Giardina, S. F., Beart, P. M., (2002) Br. J. Pharmacol, 135, p. 1733
Park, D. S. Proc. Natl. Acad. Sci. USA, 2000, 97, 10254Wang, F., Corbett, D., Osuga, H., Osuga, S., Ikeda, J. S., Slack, R. S., Hogan, M. J., Park, D. S., (2002) J. Cereb. Blood. Flow. Metab, 22, p. 171
Lopes, J. P., Oliveira, C. R., Agostinho, P., (2007) Cell. Mol. Neurobiol, 27, p. 943
Adams, P. D., Li, X., Sellers, W. R., Baker, K. B., Leng, X., Harper, J. W., Taya, Y., Kaelin Jr., W. G., (1999) Mol. Cell. Biol, 19, p. 1068
Welburn, J. P. I., Endicott, J. A., (2005) Sem. Cell Devel. Biol, 16, p. 369
Patrick, G. N., Zukerberg, L., Nikolic, M., de la Monte, S., Dikkes, P., Tsai, L. H., (1999) Nature, 402, p. 615
Lee, M. S., (2000) Nature, 405, p. 360
Fuentealba, R. A., Farias, G., Scheu, J., Bronfman, M., Marzolo, M. P., Inestrosa, N. C., (2004) Brain Res. Brain Res. Rev, 2004 (47), p. 275
Demidenko, Z. N., Blagosklonny, M. V., (2004) Cancer Res, 64, p. 3653
Senderowicz, A. M., Headlee, D., Stinson, S. F., Lush, R. M., Kalil, N., Villalba, L., Hill, K., Sausville, E. A., (1998) J. Clin. Oncol, 16, p. 2986
Tan, A. R., Headlee, D., Messmann, R., Sausville, E. A., Arbuck, S. G., Murgo, A. J., Melillo, G., Senderowicz, A. M., (2002) J. Clin. Oncol, 20, p. 4074
Horton, J. K., Joyce-Gray, D. F., Pachkowski, B. F., Swenberg, J. A., Wilson, S. H., (2003) DNA Repair, 2, p. 27
Deng, J. -Z., Sun, D. -A., Starck, S. R., Hecht, S. M., Cerny, R. L., Engen, J. R (1999) J. Chem. Soc. Perkin Trans, 1, p. 1147
Sun, D. A., Starck, S. R., Locke, E. P., Hecht, S. M (1999) J. Nat. Prod, 62, p. 1110
Deng, J. -Z., Starck, S. R., Hecht, S. M., (1999) J. Nat. Prod, 62, p. 477
Anderson, K. S., (2002) Biochim. Biophys. Acta, 1587, p. 296
Sawaya, M. R., Prasad, R., Wilson, S. H., Kraut, J., Pelletier, H., (1997) Biochemistry, 36, p. 11205
Hu, H. Y., Horton, J. K., Gryk, M. R., Prasad, R., Naron, J. M., Sun, D. A., Hecht, S. M., Mullen, G. P., (2004) J. Biol. Chem, 279, p. 39736
Moon, A. F., Garcia-Diaz, M., Batra, V. K., Beard, W. A., Bebenek, K., Kunkel, T. A., Wilson, S. H., Pedersen, L. C., (2007) DNA Repair, 6, p. 1709
Zerbe, L. K., Kuchta, R. D., (2002) Biochemistry, 41, p. 4891
Kirk, B. W., Kuchta, R. D., (1999) Biochemistry, 38, p. 7727
Low, C. M. R., Vinter, J. G., (2008) J. Med. Chem, 51, p. 565
Irwi, J. J., Shoichet, B. K., (2004) J. Chem. Inf. Model, 45, p. 177
Taha, M. O., Bustanji, Y., Al-Bakri, A. G., Yousef, A. -M., Zalloum, W. A., Al-Masri, I. M., Atallah, N., (2007) J. Mol. Graph. Model, 25, p. 870
Agrafiotis, D. K., Gibbs, A. C., Zhu, F., Izrailev, S., Martin, E., (2007) J. Chem. Inf. Model, 47, p. 1067
Gibbs, J. E., Thomas, S. A., (2002) J. Neurochem, 80, p. 392
Biade, S. R., Sobol, W., Wilson, S. H., Matsumoto, Y., (1998) J. Biol. Chem, 273, p. 898
The cell cycle molecules behind neurodegeneration in Alzheimer's disease: Perspectives for drug development
Alzheimer's disease (AD), the leading cause of senile dementia, has become a considerable social and economical problem. Current AD therapeutics provide mainly symptomatic short-term benefit, rather than targeting disease mechanisms. The hallmarks for AD are β-amyloid plaques, neurofibrillary tangles, and regionalized neuronal loss. Additional neuropathological features have been described that may provide some clues to the mechanism by which neurons die in AD. Specifically, the aberrant expression of cell cycle proteins and the presence of de novo-replicated DNA in neurons have been described both in AD brain and in culture models of the disease. The unscheduled cell cycle events are deleterious to neurons, which undergo death rather than complete the cell cycle. Although our understanding of the neuronal cell cycle is not complete, experimental evidence suggests that compounds able of arresting the aberrant cell cycle will yield neuroprotection. This review focuses on drug development centered on the cell cycle hypothesis of AD. © 2008 Bentham Science Publishers Ltd.
Alzheimer's disease (AD), the leading cause of senile dementia, has become a considerable social and economical problem. Current AD therapeutics provide mainly symptomatic short-term benefit, rather than targeting disease mechanisms. The hallmarks for AD are β-amyloid plaques, neurofibrillary tangles, and regionalized neuronal loss. Additional neuropathological features have been described that may provide some clues to the mechanism by which neurons die in AD. Specifically, the aberrant expression of cell cycle proteins and the presence of de novo-replicated DNA in neurons have been described both in AD brain and in culture models of the disease. The unscheduled cell cycle events are deleterious to neurons, which undergo death rather than complete the cell cycle. Although our understanding of the neuronal cell cycle is not complete, experimental evidence suggests that compounds able of arresting the aberrant cell cycle will yield neuroprotection. This review focuses on drug development centered on the cell cycle hypothesis of AD. © 2008 Bentham Science Publishers Ltd.
The cell cycle molecules behind neurodegeneration in Alzheimer's disease: Perspectives for drug development
| ▼ Biochemical and structural insights on Chromatin Assembly Factor 1 in physio/pathological events |
| ▼ Structural characterization of the porphyrins/proteasome interaction |
The cell cycle molecules behind neurodegeneration in Alzheimer's disease: Perspectives for drug development
Other filter: ([btitle,keywords] "β-Amyloid" OR [btit ...
Ayoub J, Buonanno M, Di Fiore A, De Simone G, Monti SM
* Biochemical and Structural Insights into the Winged Helix Domain of P150, the Largest Subunit of the Chromatin Assembly Factor (10 views)
Int J Mol Sci (ISSN: 1422-0067linking), 2022 Feb 15; 23(4): 2160-2160.
Impact Factor: 6.208
View Export to BibTeX Export to EndNote
Marasco D, Vicidomini C, Krupa P, Cioffi F, Pham DQH, Li MS, Florio D, Broersen K, De Pandis MF, Roviello GN
* Plant isoquinoline alkaloids as potential neurodrugs: A comparative study of the effects of benzo[c]phenanthridine and berberine based compounds on β-amyloid aggregation (145 views)
Chem Biol Interact (ISSN: 0009-2797linking), 2021 Jan 25; 334: 109300-109301.
Impact Factor: 5.192
View Export to BibTeX Export to EndNote
Ala U, Manco M, Mandili G, Tolosano E, Novelli F, Provero P, Altruda F, Fagoonee S
* Proteomics-Based Evidence for a Pro-Oncogenic Role of ESRP1 in Human Colorectal Cancer Cells (128 views)
Int J Mol Sc (ISSN: 1422-0067linking, 1661-6596, 1422-0067electronic), 2020 Jan 16; 21 (2 ): N/D-N/D.
Impact Factor: 2.598
View Export to BibTeX Export to EndNote
Miceli M, Cutignano A, Conte M, Ummarino R, Romanelli A, Ruvo M, Leone M, Mercurio FA, Doti N, Manzo E, Romano G, Altucci L, Ianora A
* Monoacylglycerides from the Diatom Skeletonema marinoi Induce Selective Cell Death in Cancer Cells (158 views)
Mar Drugs (ISSN: 1660-3397linking), 2019 Nov 1; 17 (11 ): N/D-N/D.
Impact Factor: 3.345
View Export to BibTeX Export to EndNote
Carella A, Roviello V, Iannitti R, Palumbo R, La Manna S, Marasco D, Trifuoggi M, Diana R, Roviello GN
* Evaluating the biological properties of synthetic 4-nitrophenyl functionalized benzofuran derivatives with telomeric DNA binding and antiproliferative activities (397 views)
Int J Biol Macromol (ISSN: 0141-8130linking, 1879-0003electronic), 2019 Jan; 121: 77-88.
Impact Factor: 4.784
View Export to BibTeX Export to EndNote
Petraglia F, Singh AA, Carafa V, Nebbioso A, Conte M, Scisciola L, Valente S, Baldi A, Mandoli A, Petrizzi VB, Ingenito C, De Falco S, Cicatiello V, Apicella I, Janssen-megens EM, Kim B, Yi G, Logie C, Heath S, Ruvo M, Wierenga ATJ, Flicek P, Yaspo ML, Della Valle V, Bernard O, Tomassi S, Novellino E, Feoli A, Sbardella G, Gut I, Vellenga E, Stunnenberg HG, Mai A, Martens JHA, Altucci L
* Combined HAT/EZH2 modulation leads to cancer-selective cell death (284 views)
Oncotarget (ISSN: 1949-2553electronic, 1949-2553linking), 2018 May 22; 9(39): 25630-25646.
Impact Factor: 5.008
View Export to BibTeX Export to EndNote
Leggio GM, Catania MV, Puzzo D, Spatuzza M, Pellitteri R, Gulisano W, Torrisi SA, Giurdanella G, Piazza C, Impellizzeri AR, Gozzo L, Navarria A, Bucolo C, Nicoletti F, Palmeri A, Salomone S, Copani A, Caraci F, Drago F
* The antineoplastic drug flavopiridol reverses memory impairment induced by Amyloid-ss1-42 oligomers in mice (504 views)
Pharmacol Res (ISSN: 1043-6618, 1096-1186electronic), 2016 Apr; 106: 10-20.
Impact Factor: 4.48
View Export to BibTeX Export to EndNote
Palladino P, Aura AM, Spoto G
* Surface plasmon resonance for the label-free detection of Alzheimer's β-amyloid peptide aggregation (528 views)
Anal Bioanal Chem (ISSN: 1618-2642), 2016; 408(3): 849-854.
Impact Factor: 3.431
View Export to BibTeX Export to EndNote
Alterio V, Langella E, De Simone G, Monti SM
* Cadmium-containing carbonic anhydrase CDCA1 in marine diatom Thalassiosira weissflogii (630 views)
Mar Drugs (ISSN: 1660-3397, 1660-3397linking), 2015 Mar 25; 13(4): 1688-1697.
Impact Factor: 3.345
View Export to BibTeX Export to EndNote
Merlo S, Basile L, Giuffrida ML, Sortino MA, Guccione S, Copani A
* Identification of 5-Methoxyflavone as a Novel DNA Polymerase-Beta Inhibitor and Neuroprotective Agent against Beta-Amyloid Toxicity (323 views)
J Nat Prod (ISSN: 0163-3864), 2015; 78(11): 2704-2711.
Impact Factor: 3.662
View Export to BibTeX Export to EndNote
Perri F, Pacelli R, Della Vittoria Scarpati G, Cella L, Giuliano M, Caponigro F, Pepe S
* Radioresistance in head and neck squamous cell carcinoma: Biological bases and therapeutic implications (522 views)
Head Neck-J Sci Spec (ISSN: 1043-3074), 2015; 37(5): 763-770.
Impact Factor: 2.76
View Export to BibTeX Export to EndNote
Correale S, de Paola I, Morgillo CM, Federico A, Zaccaro L, Pallante P, Galeone A, Fusco A, Pedone E, Luque FJ, Catalanotti B
* Structural Model of the hUbA1-UbcH10 Quaternary Complex: In Silico and Experimental Analysis of the Protein-Protein Interactions between E1, E2 and Ubiquitin (434 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2014 Nov 6; 9(11): e112082-e112082.
Impact Factor: 3.234
View Export to BibTeX Export to EndNote
Tornatore L, Sandomenico A, Raimondo D, Low C, Rocci A, Tralau-Stewart C, Capece D, D'Andrea D, Bua M, Boyle E, van Duin M, Zoppoli P, Jaxa-Chamiec A, Thotakura AK, Dyson J, Walker BA, Leonardi A, Chambery A, Driessen C, Sonneveld P, Morgan G, Palumbo A, Tramontano A, Rahemtulla A, Ruvo M, Franzoso G
* Cancer-selective targeting of the NF-kappaB survival pathway with GADD45beta/MKK7 inhibitors (623 views)
Cancer Cell (ISSN: 1535-6108), 2014 Oct 13; 26(4): 495-508.
Impact Factor: 23.523
View Export to BibTeX Export to EndNote
Nande R, Greco A, Gossman MS, Lopez JP, Claudio L, Salvatore M, Brunetti A, Denvir J, Howard CM, Claudio PP
* Microbubble-assisted p53, RB, and p130 gene transfer in combination with radiation therapy in prostate cancer (457 views)
Current Gene Therapy (ISSN: 1875-5631, 1566-5232), 2013 Jun 1; 13(3): 163-174.
Impact Factor: 4.906
View Export to BibTeX Export to EndNote
Galdiero S, Falanga A, Tarallo R, Russo L, Galdiero E, Cantisani M, Morelli G, Galdiero M
* Peptide inhibitors against herpes simplex virus infections (888 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2013 Mar; 19(3): 148-158.
Impact Factor: 1.862
View Export to BibTeX Export to EndNote
Ruggiero A, De Simone P, Smaldone G, Squeglia F, Berisio R
* Bacterial cell division regulation by Ser/Thr kinases: A structural perspective (581 views)
Curr Protein Pept Sci (ISSN: 1389-2037, 1389-2037linking), 2012 Dec; 13(8): 756-766.
Impact Factor: 2.326
View Export to BibTeX Export to EndNote
Giuffrida ML, Tomasello F, Caraci F, Chiechio S, Nicoletti F, Copani A
* Beta-Amyloid monomer and insulin/IGF-1 signaling in Alzheimer's disease (1054 views)
Mol Neurobiol (ISSN: 0893-7648), 2012 Dec; 46(3): 605-613.
Impact Factor: 5.471
View Export to BibTeX Export to EndNote
Merolla F, Luise C, Muller MT, Pacelli R, Fusco A, Celetti A
* Loss of CCDC6, the First Identified RET Partner Gene, Affects pH2AX S139 Levels and Accelerates Mitotic Entry upon DNA Damage (361 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2012 May 24; 7(5): N/D-N/D.
Impact Factor: 3.73
View Export to BibTeX Export to EndNote
Zannetti A, Iommelli F, Speranza A, Salvatore M, Del Vecchio S
* 3'-deoxy-3'-18F-fluorothymidine (FLT) PET/CT to guide therapy with epidermal growth factor receptor (EGFR) antagonists and Bcl-xL inhibitors in non-small cell lung cancer (614 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 2012 Mar 1; 53(3): 443-450.
Impact Factor: 5.774
View Export to BibTeX Export to EndNote
Zannetti A, Iommelli F, Speranza A, Salvatore M, Del Vecchio S
* 3'-deoxy-3'-18F-fluorothymidine PET/CT to guide therapy with epidermal growth factor receptor antagonists and Bcl-xL inhibitors in non-small cell lung cancer (525 views)
J Nucl Med (ISSN: 1535-5667, 0161-5505, 1535-5667electronic), 2012 Mar 1; 53(3): 443-450.
Impact Factor: 5.774
View Export to BibTeX Export to EndNote
Calafiore M, Copani A, Deng W
* DNA polymerase-β mediates the neurogenic effect of β-amyloid protein in cultured subventricular zone neurospheres (597 views)
Journal Of Neuroscience Research (ISSN: 0360-4012), 2012 Mar; 90(3): 559-567.
Impact Factor: 2.974
View Export to BibTeX Export to EndNote
Caraci F, Spampinato S, Sortino MA, Bosco P, Battaglia G, Bruno V, Drago F, Nicoletti F, Copani A
* Dysfunction of TGF-β1 signaling in Alzheimer's disease: Perspectives for neuroprotection (972 views)
Cell Tissue Res (ISSN: 0302-766x), 2012 Jan; 347(1): 291-301.
Impact Factor: 3.677
View Export to BibTeX Export to EndNote
Palmieri D, Valentino T, D'Angelo D, De Martino I, Postiglione I, Pacelli R, Croce CM, Fedele M, Fusco A
* HMGA proteins promote ATM expression and enhance cancer cell resistance to genotoxic agents (870 views)
Oncogene (ISSN: 0950-9232, 1476-5594), 2011 Jul 7; 30(27): 3024-3035.
Impact Factor: 6.373
View Export to BibTeX Export to EndNote
Milite C, Castellano S, Benedetti R, Tosco A, Ciliberti C, Vicidomini C, Boully L, Franci G, Altucci L, Mai A, Sbardella G
* Modulation of the activity of histone acetyltransferases by long chain alkylidenemalonates (LoCAMs) (360 views)
Bioorg Med Chem (ISSN: 0968-0896, 1464-3391, 1464-3391electronic), 2011 Jun 15; 19(12): 3690-3701.
Impact Factor: 2.921
View Export to BibTeX Export to EndNote
Caraci F, Molinaro G, Battaglia G, Giuffrida ML, Riozzi B, Traficante A, Bruno V, Cannella M, Merlo S, Wang X, Heinz BA, Nisenbaum ES, Britton TC, Drago F, Sortino MA, Copani A, Nicoletti F
* Targeting group II Metabotropic Glutamate (mGlu) receptors for the treatment of psychosis associated with alzheimer's disease: Selective activation of mGlu2 receptors amplifies β-amyloid toxicity in cultured neurons, whereas dual activation of mGlu2 and mGlu3 receptors is neuroprotective (748 views)
Mol Pharmacol (ISSN: 0026-895x), 2011 Mar; 79(3): 618-626.
Impact Factor: 4.883
View Export to BibTeX Export to EndNote
Farina AR, Tacconelli A, Cappabianca L, Cea G, Panella S, Chioda A, Romanelli A, Pedone C, Gulino A, Mackay AR
* The alternative TrkAIII splice variant targets the centrosome and promotes genetic instability (358 views)
Mol Cell Biol (ISSN: 1098-5549, 0270-7306), 2009 Sep 1; 29(17): 4812-4830.
Impact Factor: 6.057
View Export to BibTeX Export to EndNote
Ciaccio C, Tundo GR, Grasso G, Spoto G, Marasco D, Ruvo M, Gioia M, Rizzarelli E, Coletta M
* Somatostatin: a novel substrate and a modulator of insulin-degrading enzyme activity (454 views)
J Mol Biol (ISSN: 1089-8638, 0022-2836, 1089-8638electronic), 2009 Feb 6; 385(5): 1556-1567.
Impact Factor: 3.871
View Export to BibTeX Export to EndNote
Pentimalli F, Palmieri D, Pacelli R, Garbi C, Cesari R, Martin E, Pierantoni GM, Chieffi P, Croce CM, Costanzo V, Fedele M, Fusco A
* HMGA1 protein is a novel target of the ATM kinase (482 views)
European Journal Of Cancer (ISSN: 0959-8049), 2008 Nov; 44(17): 2668-2679.
Impact Factor: 4.475
View Export to BibTeX Export to EndNote
Castiglione M, Calafiore M, Costa L, Sortino MA, Nicoletti F, Copani A
* Group I metabotropic glutamate receptors control proliferation, survival and differentiation of cultured neural progenitor cells isolated from the subventricular zone of adult mice (424 views)
Neuropharm (ISSN: 0028-3908, 1873-7064electronic, 0028-3908linking), 2008 Sep; 55(4): 560-567.
Impact Factor: 3.383
View Export to BibTeX Export to EndNote
Sbardella G, Castellano S, Vicidomini C, Rotili D, Nebbioso A, Miceli M, Altucci L, Mai A
* Identification of long chain alkylidenemalonates as novel small molecule modulators of histone acetyltransferases (313 views)
Bioorganic & Medicinal Chemistry Letters (ISSN: 0960-894x), 2008 May 1; 18(9): 2788-2792.
Impact Factor: 2.531
View Export to BibTeX Export to EndNote
Caraci F, Battaglia G, Busceti C, Biagioni F, Mastroiacovo F, Bosco P, Drago F, Nicoletti F, Sortino MA, Copani A
* TGF-β1 protects against Aβ-neurotoxicity via the phosphatidylinositol-3-kinase pathway (378 views)
Neurobiology Of Disease (ISSN: 0969-9961), 2008 May; 30(2): 234-242.
Impact Factor: 4.852
View Export to BibTeX Export to EndNote
Prato S, Vitale RM, Contursi P, Lipps G, Saviano M, Rossi M, Bartolucci S
* Molecular modeling and functional characterization of the monomeric primase-polymerase domain from the Sulfolobus solfataricus plasmid pIT3 (398 views)
Febs J (ISSN: 1742-464x), 2008; 275(17): 4389-4402.
Impact Factor: 3.139
View Export to BibTeX Export to EndNote
Merolla F, Pentimalli F, Pacelli R, Vecchio G, Fusco A, Grieco M, Celetti A
* Involvement of H4(D10S170) protein in ATM-dependent response to DNA damage (606 views)
Oncogene (ISSN: 0950-9232, 1476-5594), 2007 Sep 13; 26(42): 6167-6175.
Impact Factor: 6.44
View Export to BibTeX Export to EndNote
Copani A, Caraci F, Hoozemans J, Calafiore M, Sortino M, Nicoletti F
* The nature of the cell cycle in neurons: Focus on a "non-canonical" pathway of DNA replication causally related to death (481 views)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2007 Apr; 1772(4): 409-412.
Impact Factor: 3.078
View Export to BibTeX Export to EndNote
Giuffrida ML, Grasso G, Ruvo M, Pedone C, Saporito A, Marasco D, Pignataro B, Cascio C, Copani A, Rizzarelli E
* Abeta(25-35) And Its C- And/Or N-Blocked Derivatives: Copper Driven Structural Features And Neurotoxicity (613 views)
Journal Of Neuroscience Research (ISSN: 0360-4012), 2007 Feb 15; 85(3): 623-633.
Impact Factor: 3.268
View Export to BibTeX Export to EndNote
Messere A, Fabbri E, Borgatti M, Gambari R, Di Blasio B, Pedone C, Romanelli A
* Antiproliferative activity of Pt(II) and Pd(II) phosphine complexes with thymine and thymidine (308 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2007 Feb; 101(2): 254-260.
Impact Factor: 3.663
View Export to BibTeX Export to EndNote
Bosco P, Caraci F, Copani A, Spada R, Sortino M, Salluzzo R, Salemi M, Nicoletti F, Ferri R
* The CDC2 I-G-T haplotype associated with the APOE ε4 allele increases the risk of sporadic Alzheimer's disease in Sicily (372 views)
Neurosci Lett (ISSN: 0304-3940), 2007; 419(3): 195-198.
Impact Factor: 2.085
View Export to BibTeX Export to EndNote
Mai A, Rotili D, Tarantino D, Ornaghi P, Tosi F, Vicidomini C, Sbardella G, Nebbioso A, Miceli M, Altucci L, Filetici P
* Small-molecule inhibitors of histone acetyltransferase activity: Identification and biological properties (523 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2006 Nov 16; 49(23): 6897-6907.
Impact Factor: 5.115
View Export to BibTeX Export to EndNote
Di Pietro C, Piro S, Tabbì G, Ragusa M, Di Pietro V, Zimmitti V, Cuda F, Anello M, Consoli U, Salinaro ET, Caruso M, Vancheri C, Crimi N, Sabini MG, Cirrone GA, Raffaele L, Privitera G, Pulvirenti A, Giugno R, Ferro A, Cuttone G, Lo Nigro S, Purrello R, Purrello F, Purrello M
* Cellular and molecular effects of protons: Apoptosis induction and potential implications for cancer therapy (520 views)
Apoptosis (ISSN: 1360-8185), 2006 Jan; 11(1): 57-66.
Impact Factor: 3.421
View Export to BibTeX Export to EndNote
Copani A, Hoozemans JJM, Caraci F, Calafiore M, Van Haastert ES, Veerhuis R, Rozemuller AJM, Aronica E, Sortino MA, Nicoletti F
* Dna Polymerase-Beta Is Expressed Early In Neurons Of Alzheimer'S Disease Brain And Is Loaded Into Dna Replication Forks In Neurons Challenged With Beta-Amyloid (491 views)
J Neurosci (ISSN: 0270-6474, 0361-803x, 1529-2401), 2006; 26(43): 10949-10957.
Impact Factor: 2.117
View Export to BibTeX Export to EndNote
Calafiore M, Battaglia G, Zappal A, Trovato-Salinaro E, Caraci F, Caruso M, Vancheri C, Sortino MA, Nicoletti F, Copani A
* Progenitor cells from the adult mouse brain acquire a neuronal phenotype in response to β-amyloid (530 views)
Neurobiol Aging (ISSN: 0197-4580, 1558-1497electronic, 0197-4580linking), 2006; 27(4): 606-613.
Impact Factor: 5.599
View Export to BibTeX Export to EndNote
Marrazzo A, Caraci F, Salinaro ET, Su TP, Copani A, Ronsisvalle G
* Neuroprotective effects of sigma-1 receptor agonists against beta-amyloid-induced toxicity (584 views)
Neuroreport (ISSN: 0959-4965), 2005 Sep 1; 16(11): 1223-1226.
Impact Factor: 1.995
View Export to BibTeX Export to EndNote
Filippo C, Mariangela C, Giuseppina F, Pier Luigi C, Angelo B, Marco C, Giuseppe B, Paolo B, Ferdinando N, Agata C, Maria Angela S
* Nicergoline, a drug used for age-dependent cognitive impairment, protects cultured neurons against β-amyloid toxicity (797 views)
Brain Res (ISSN: 0006-8993), 2005; 1047(1): 30-37.
Impact Factor: 2.296
View Export to BibTeX Export to EndNote
Caricasole A, Copani A, Caraci F, Aronica E, Rozemuller AJ, Caruso A, Storto M, Gaviraghi G, Terstappen GC, Nicoletti F
* Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain (543 views)
J Neurosci (ISSN: 0270-6474, 0361-803x, 1529-2401), 2004 Jun 30; 24(26): 6021-6027.
Impact Factor: 2.384
View Export to BibTeX Export to EndNote
Herscher LL, Cook JA, Pacelli R, Pass HI, Russo A, Mitchell JB
Principles of chemoradiation: Theoretical and practical considerations (406 views)
Oncology (ISSN: 0890-9091), 1999 Oct; 13(10SUPPL.5): 11-22.
Impact Factor: 0.933
View Export to BibTeX Export to EndNote
Cook JA, Krishna MC, Pacelli R, DeGraff W, Liebmann J, Mitchell JB, Russo A, Wink DA
Nitric oxide enhancement of melphalan-induced cytotoxicity (486 views)
Br J Cancer (ISSN: 0007-0920, 0007-0920print, 0007-0920linking), 1997 Sep; 76(3): 325-334.
Impact Factor: 2.938
View Export to BibTeX Export to EndNote
Scala S, Pacelli R, Iaffaioli RV, Normanno N, Pepe S, Frasci G, Genua G, Tsuruo T, Tagliaferri P, Bianco AR
Reversal of adriamycin resistance by recombinant α-interferon in multidrug-resistant human colon carcinoma LoVo-doxorubicin cells (559 views)
Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 1991 Sep 15; 51(18): 4898-4902.
Impact Factor: 8.426
View Export to BibTeX Export to EndNote
* Biochemical and Structural Insights into the Winged Helix Domain of P150, the Largest Subunit of the Chromatin Assembly Factor (10 views)
Int J Mol Sci (ISSN: 1422-0067linking), 2022 Feb 15; 23(4): 2160-2160.
Impact Factor: 6.208
View Export to BibTeX Export to EndNote
Marasco D, Vicidomini C, Krupa P, Cioffi F, Pham DQH, Li MS, Florio D, Broersen K, De Pandis MF, Roviello GN
* Plant isoquinoline alkaloids as potential neurodrugs: A comparative study of the effects of benzo[c]phenanthridine and berberine based compounds on β-amyloid aggregation (145 views)
Chem Biol Interact (ISSN: 0009-2797linking), 2021 Jan 25; 334: 109300-109301.
Impact Factor: 5.192
View Export to BibTeX Export to EndNote
Ala U, Manco M, Mandili G, Tolosano E, Novelli F, Provero P, Altruda F, Fagoonee S
* Proteomics-Based Evidence for a Pro-Oncogenic Role of ESRP1 in Human Colorectal Cancer Cells (128 views)
Int J Mol Sc (ISSN: 1422-0067linking, 1661-6596, 1422-0067electronic), 2020 Jan 16; 21 (2 ): N/D-N/D.
Impact Factor: 2.598
View Export to BibTeX Export to EndNote
Miceli M, Cutignano A, Conte M, Ummarino R, Romanelli A, Ruvo M, Leone M, Mercurio FA, Doti N, Manzo E, Romano G, Altucci L, Ianora A
* Monoacylglycerides from the Diatom Skeletonema marinoi Induce Selective Cell Death in Cancer Cells (158 views)
Mar Drugs (ISSN: 1660-3397linking), 2019 Nov 1; 17 (11 ): N/D-N/D.
Impact Factor: 3.345
View Export to BibTeX Export to EndNote
Carella A, Roviello V, Iannitti R, Palumbo R, La Manna S, Marasco D, Trifuoggi M, Diana R, Roviello GN
* Evaluating the biological properties of synthetic 4-nitrophenyl functionalized benzofuran derivatives with telomeric DNA binding and antiproliferative activities (397 views)
Int J Biol Macromol (ISSN: 0141-8130linking, 1879-0003electronic), 2019 Jan; 121: 77-88.
Impact Factor: 4.784
View Export to BibTeX Export to EndNote
Petraglia F, Singh AA, Carafa V, Nebbioso A, Conte M, Scisciola L, Valente S, Baldi A, Mandoli A, Petrizzi VB, Ingenito C, De Falco S, Cicatiello V, Apicella I, Janssen-megens EM, Kim B, Yi G, Logie C, Heath S, Ruvo M, Wierenga ATJ, Flicek P, Yaspo ML, Della Valle V, Bernard O, Tomassi S, Novellino E, Feoli A, Sbardella G, Gut I, Vellenga E, Stunnenberg HG, Mai A, Martens JHA, Altucci L
* Combined HAT/EZH2 modulation leads to cancer-selective cell death (284 views)
Oncotarget (ISSN: 1949-2553electronic, 1949-2553linking), 2018 May 22; 9(39): 25630-25646.
Impact Factor: 5.008
View Export to BibTeX Export to EndNote
Leggio GM, Catania MV, Puzzo D, Spatuzza M, Pellitteri R, Gulisano W, Torrisi SA, Giurdanella G, Piazza C, Impellizzeri AR, Gozzo L, Navarria A, Bucolo C, Nicoletti F, Palmeri A, Salomone S, Copani A, Caraci F, Drago F
* The antineoplastic drug flavopiridol reverses memory impairment induced by Amyloid-ss1-42 oligomers in mice (504 views)
Pharmacol Res (ISSN: 1043-6618, 1096-1186electronic), 2016 Apr; 106: 10-20.
Impact Factor: 4.48
View Export to BibTeX Export to EndNote
Palladino P, Aura AM, Spoto G
* Surface plasmon resonance for the label-free detection of Alzheimer's β-amyloid peptide aggregation (528 views)
Anal Bioanal Chem (ISSN: 1618-2642), 2016; 408(3): 849-854.
Impact Factor: 3.431
View Export to BibTeX Export to EndNote
Alterio V, Langella E, De Simone G, Monti SM
* Cadmium-containing carbonic anhydrase CDCA1 in marine diatom Thalassiosira weissflogii (630 views)
Mar Drugs (ISSN: 1660-3397, 1660-3397linking), 2015 Mar 25; 13(4): 1688-1697.
Impact Factor: 3.345
View Export to BibTeX Export to EndNote
Merlo S, Basile L, Giuffrida ML, Sortino MA, Guccione S, Copani A
* Identification of 5-Methoxyflavone as a Novel DNA Polymerase-Beta Inhibitor and Neuroprotective Agent against Beta-Amyloid Toxicity (323 views)
J Nat Prod (ISSN: 0163-3864), 2015; 78(11): 2704-2711.
Impact Factor: 3.662
View Export to BibTeX Export to EndNote
Perri F, Pacelli R, Della Vittoria Scarpati G, Cella L, Giuliano M, Caponigro F, Pepe S
* Radioresistance in head and neck squamous cell carcinoma: Biological bases and therapeutic implications (522 views)
Head Neck-J Sci Spec (ISSN: 1043-3074), 2015; 37(5): 763-770.
Impact Factor: 2.76
View Export to BibTeX Export to EndNote
Correale S, de Paola I, Morgillo CM, Federico A, Zaccaro L, Pallante P, Galeone A, Fusco A, Pedone E, Luque FJ, Catalanotti B
* Structural Model of the hUbA1-UbcH10 Quaternary Complex: In Silico and Experimental Analysis of the Protein-Protein Interactions between E1, E2 and Ubiquitin (434 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2014 Nov 6; 9(11): e112082-e112082.
Impact Factor: 3.234
View Export to BibTeX Export to EndNote
Tornatore L, Sandomenico A, Raimondo D, Low C, Rocci A, Tralau-Stewart C, Capece D, D'Andrea D, Bua M, Boyle E, van Duin M, Zoppoli P, Jaxa-Chamiec A, Thotakura AK, Dyson J, Walker BA, Leonardi A, Chambery A, Driessen C, Sonneveld P, Morgan G, Palumbo A, Tramontano A, Rahemtulla A, Ruvo M, Franzoso G
* Cancer-selective targeting of the NF-kappaB survival pathway with GADD45beta/MKK7 inhibitors (623 views)
Cancer Cell (ISSN: 1535-6108), 2014 Oct 13; 26(4): 495-508.
Impact Factor: 23.523
View Export to BibTeX Export to EndNote
Nande R, Greco A, Gossman MS, Lopez JP, Claudio L, Salvatore M, Brunetti A, Denvir J, Howard CM, Claudio PP
* Microbubble-assisted p53, RB, and p130 gene transfer in combination with radiation therapy in prostate cancer (457 views)
Current Gene Therapy (ISSN: 1875-5631, 1566-5232), 2013 Jun 1; 13(3): 163-174.
Impact Factor: 4.906
View Export to BibTeX Export to EndNote
Galdiero S, Falanga A, Tarallo R, Russo L, Galdiero E, Cantisani M, Morelli G, Galdiero M
* Peptide inhibitors against herpes simplex virus infections (888 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2013 Mar; 19(3): 148-158.
Impact Factor: 1.862
View Export to BibTeX Export to EndNote
Ruggiero A, De Simone P, Smaldone G, Squeglia F, Berisio R
* Bacterial cell division regulation by Ser/Thr kinases: A structural perspective (581 views)
Curr Protein Pept Sci (ISSN: 1389-2037, 1389-2037linking), 2012 Dec; 13(8): 756-766.
Impact Factor: 2.326
View Export to BibTeX Export to EndNote
Giuffrida ML, Tomasello F, Caraci F, Chiechio S, Nicoletti F, Copani A
* Beta-Amyloid monomer and insulin/IGF-1 signaling in Alzheimer's disease (1054 views)
Mol Neurobiol (ISSN: 0893-7648), 2012 Dec; 46(3): 605-613.
Impact Factor: 5.471
View Export to BibTeX Export to EndNote
Merolla F, Luise C, Muller MT, Pacelli R, Fusco A, Celetti A
* Loss of CCDC6, the First Identified RET Partner Gene, Affects pH2AX S139 Levels and Accelerates Mitotic Entry upon DNA Damage (361 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2012 May 24; 7(5): N/D-N/D.
Impact Factor: 3.73
View Export to BibTeX Export to EndNote
Zannetti A, Iommelli F, Speranza A, Salvatore M, Del Vecchio S
* 3'-deoxy-3'-18F-fluorothymidine (FLT) PET/CT to guide therapy with epidermal growth factor receptor (EGFR) antagonists and Bcl-xL inhibitors in non-small cell lung cancer (614 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 2012 Mar 1; 53(3): 443-450.
Impact Factor: 5.774
View Export to BibTeX Export to EndNote
Zannetti A, Iommelli F, Speranza A, Salvatore M, Del Vecchio S
* 3'-deoxy-3'-18F-fluorothymidine PET/CT to guide therapy with epidermal growth factor receptor antagonists and Bcl-xL inhibitors in non-small cell lung cancer (525 views)
J Nucl Med (ISSN: 1535-5667, 0161-5505, 1535-5667electronic), 2012 Mar 1; 53(3): 443-450.
Impact Factor: 5.774
View Export to BibTeX Export to EndNote
Calafiore M, Copani A, Deng W
* DNA polymerase-β mediates the neurogenic effect of β-amyloid protein in cultured subventricular zone neurospheres (597 views)
Journal Of Neuroscience Research (ISSN: 0360-4012), 2012 Mar; 90(3): 559-567.
Impact Factor: 2.974
View Export to BibTeX Export to EndNote
Caraci F, Spampinato S, Sortino MA, Bosco P, Battaglia G, Bruno V, Drago F, Nicoletti F, Copani A
* Dysfunction of TGF-β1 signaling in Alzheimer's disease: Perspectives for neuroprotection (972 views)
Cell Tissue Res (ISSN: 0302-766x), 2012 Jan; 347(1): 291-301.
Impact Factor: 3.677
View Export to BibTeX Export to EndNote
Palmieri D, Valentino T, D'Angelo D, De Martino I, Postiglione I, Pacelli R, Croce CM, Fedele M, Fusco A
* HMGA proteins promote ATM expression and enhance cancer cell resistance to genotoxic agents (870 views)
Oncogene (ISSN: 0950-9232, 1476-5594), 2011 Jul 7; 30(27): 3024-3035.
Impact Factor: 6.373
View Export to BibTeX Export to EndNote
Milite C, Castellano S, Benedetti R, Tosco A, Ciliberti C, Vicidomini C, Boully L, Franci G, Altucci L, Mai A, Sbardella G
* Modulation of the activity of histone acetyltransferases by long chain alkylidenemalonates (LoCAMs) (360 views)
Bioorg Med Chem (ISSN: 0968-0896, 1464-3391, 1464-3391electronic), 2011 Jun 15; 19(12): 3690-3701.
Impact Factor: 2.921
View Export to BibTeX Export to EndNote
Caraci F, Molinaro G, Battaglia G, Giuffrida ML, Riozzi B, Traficante A, Bruno V, Cannella M, Merlo S, Wang X, Heinz BA, Nisenbaum ES, Britton TC, Drago F, Sortino MA, Copani A, Nicoletti F
* Targeting group II Metabotropic Glutamate (mGlu) receptors for the treatment of psychosis associated with alzheimer's disease: Selective activation of mGlu2 receptors amplifies β-amyloid toxicity in cultured neurons, whereas dual activation of mGlu2 and mGlu3 receptors is neuroprotective (748 views)
Mol Pharmacol (ISSN: 0026-895x), 2011 Mar; 79(3): 618-626.
Impact Factor: 4.883
View Export to BibTeX Export to EndNote
Farina AR, Tacconelli A, Cappabianca L, Cea G, Panella S, Chioda A, Romanelli A, Pedone C, Gulino A, Mackay AR
* The alternative TrkAIII splice variant targets the centrosome and promotes genetic instability (358 views)
Mol Cell Biol (ISSN: 1098-5549, 0270-7306), 2009 Sep 1; 29(17): 4812-4830.
Impact Factor: 6.057
View Export to BibTeX Export to EndNote
Ciaccio C, Tundo GR, Grasso G, Spoto G, Marasco D, Ruvo M, Gioia M, Rizzarelli E, Coletta M
* Somatostatin: a novel substrate and a modulator of insulin-degrading enzyme activity (454 views)
J Mol Biol (ISSN: 1089-8638, 0022-2836, 1089-8638electronic), 2009 Feb 6; 385(5): 1556-1567.
Impact Factor: 3.871
View Export to BibTeX Export to EndNote
Pentimalli F, Palmieri D, Pacelli R, Garbi C, Cesari R, Martin E, Pierantoni GM, Chieffi P, Croce CM, Costanzo V, Fedele M, Fusco A
* HMGA1 protein is a novel target of the ATM kinase (482 views)
European Journal Of Cancer (ISSN: 0959-8049), 2008 Nov; 44(17): 2668-2679.
Impact Factor: 4.475
View Export to BibTeX Export to EndNote
Castiglione M, Calafiore M, Costa L, Sortino MA, Nicoletti F, Copani A
* Group I metabotropic glutamate receptors control proliferation, survival and differentiation of cultured neural progenitor cells isolated from the subventricular zone of adult mice (424 views)
Neuropharm (ISSN: 0028-3908, 1873-7064electronic, 0028-3908linking), 2008 Sep; 55(4): 560-567.
Impact Factor: 3.383
View Export to BibTeX Export to EndNote
Sbardella G, Castellano S, Vicidomini C, Rotili D, Nebbioso A, Miceli M, Altucci L, Mai A
* Identification of long chain alkylidenemalonates as novel small molecule modulators of histone acetyltransferases (313 views)
Bioorganic & Medicinal Chemistry Letters (ISSN: 0960-894x), 2008 May 1; 18(9): 2788-2792.
Impact Factor: 2.531
View Export to BibTeX Export to EndNote
Caraci F, Battaglia G, Busceti C, Biagioni F, Mastroiacovo F, Bosco P, Drago F, Nicoletti F, Sortino MA, Copani A
* TGF-β1 protects against Aβ-neurotoxicity via the phosphatidylinositol-3-kinase pathway (378 views)
Neurobiology Of Disease (ISSN: 0969-9961), 2008 May; 30(2): 234-242.
Impact Factor: 4.852
View Export to BibTeX Export to EndNote
Prato S, Vitale RM, Contursi P, Lipps G, Saviano M, Rossi M, Bartolucci S
* Molecular modeling and functional characterization of the monomeric primase-polymerase domain from the Sulfolobus solfataricus plasmid pIT3 (398 views)
Febs J (ISSN: 1742-464x), 2008; 275(17): 4389-4402.
Impact Factor: 3.139
View Export to BibTeX Export to EndNote
Merolla F, Pentimalli F, Pacelli R, Vecchio G, Fusco A, Grieco M, Celetti A
* Involvement of H4(D10S170) protein in ATM-dependent response to DNA damage (606 views)
Oncogene (ISSN: 0950-9232, 1476-5594), 2007 Sep 13; 26(42): 6167-6175.
Impact Factor: 6.44
View Export to BibTeX Export to EndNote
Copani A, Caraci F, Hoozemans J, Calafiore M, Sortino M, Nicoletti F
* The nature of the cell cycle in neurons: Focus on a "non-canonical" pathway of DNA replication causally related to death (481 views)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2007 Apr; 1772(4): 409-412.
Impact Factor: 3.078
View Export to BibTeX Export to EndNote
Giuffrida ML, Grasso G, Ruvo M, Pedone C, Saporito A, Marasco D, Pignataro B, Cascio C, Copani A, Rizzarelli E
* Abeta(25-35) And Its C- And/Or N-Blocked Derivatives: Copper Driven Structural Features And Neurotoxicity (613 views)
Journal Of Neuroscience Research (ISSN: 0360-4012), 2007 Feb 15; 85(3): 623-633.
Impact Factor: 3.268
View Export to BibTeX Export to EndNote
Messere A, Fabbri E, Borgatti M, Gambari R, Di Blasio B, Pedone C, Romanelli A
* Antiproliferative activity of Pt(II) and Pd(II) phosphine complexes with thymine and thymidine (308 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2007 Feb; 101(2): 254-260.
Impact Factor: 3.663
View Export to BibTeX Export to EndNote
Bosco P, Caraci F, Copani A, Spada R, Sortino M, Salluzzo R, Salemi M, Nicoletti F, Ferri R
* The CDC2 I-G-T haplotype associated with the APOE ε4 allele increases the risk of sporadic Alzheimer's disease in Sicily (372 views)
Neurosci Lett (ISSN: 0304-3940), 2007; 419(3): 195-198.
Impact Factor: 2.085
View Export to BibTeX Export to EndNote
Mai A, Rotili D, Tarantino D, Ornaghi P, Tosi F, Vicidomini C, Sbardella G, Nebbioso A, Miceli M, Altucci L, Filetici P
* Small-molecule inhibitors of histone acetyltransferase activity: Identification and biological properties (523 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2006 Nov 16; 49(23): 6897-6907.
Impact Factor: 5.115
View Export to BibTeX Export to EndNote
Di Pietro C, Piro S, Tabbì G, Ragusa M, Di Pietro V, Zimmitti V, Cuda F, Anello M, Consoli U, Salinaro ET, Caruso M, Vancheri C, Crimi N, Sabini MG, Cirrone GA, Raffaele L, Privitera G, Pulvirenti A, Giugno R, Ferro A, Cuttone G, Lo Nigro S, Purrello R, Purrello F, Purrello M
* Cellular and molecular effects of protons: Apoptosis induction and potential implications for cancer therapy (520 views)
Apoptosis (ISSN: 1360-8185), 2006 Jan; 11(1): 57-66.
Impact Factor: 3.421
View Export to BibTeX Export to EndNote
Copani A, Hoozemans JJM, Caraci F, Calafiore M, Van Haastert ES, Veerhuis R, Rozemuller AJM, Aronica E, Sortino MA, Nicoletti F
* Dna Polymerase-Beta Is Expressed Early In Neurons Of Alzheimer'S Disease Brain And Is Loaded Into Dna Replication Forks In Neurons Challenged With Beta-Amyloid (491 views)
J Neurosci (ISSN: 0270-6474, 0361-803x, 1529-2401), 2006; 26(43): 10949-10957.
Impact Factor: 2.117
View Export to BibTeX Export to EndNote
Calafiore M, Battaglia G, Zappal A, Trovato-Salinaro E, Caraci F, Caruso M, Vancheri C, Sortino MA, Nicoletti F, Copani A
* Progenitor cells from the adult mouse brain acquire a neuronal phenotype in response to β-amyloid (530 views)
Neurobiol Aging (ISSN: 0197-4580, 1558-1497electronic, 0197-4580linking), 2006; 27(4): 606-613.
Impact Factor: 5.599
View Export to BibTeX Export to EndNote
Marrazzo A, Caraci F, Salinaro ET, Su TP, Copani A, Ronsisvalle G
* Neuroprotective effects of sigma-1 receptor agonists against beta-amyloid-induced toxicity (584 views)
Neuroreport (ISSN: 0959-4965), 2005 Sep 1; 16(11): 1223-1226.
Impact Factor: 1.995
View Export to BibTeX Export to EndNote
Filippo C, Mariangela C, Giuseppina F, Pier Luigi C, Angelo B, Marco C, Giuseppe B, Paolo B, Ferdinando N, Agata C, Maria Angela S
* Nicergoline, a drug used for age-dependent cognitive impairment, protects cultured neurons against β-amyloid toxicity (797 views)
Brain Res (ISSN: 0006-8993), 2005; 1047(1): 30-37.
Impact Factor: 2.296
View Export to BibTeX Export to EndNote
Caricasole A, Copani A, Caraci F, Aronica E, Rozemuller AJ, Caruso A, Storto M, Gaviraghi G, Terstappen GC, Nicoletti F
* Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain (543 views)
J Neurosci (ISSN: 0270-6474, 0361-803x, 1529-2401), 2004 Jun 30; 24(26): 6021-6027.
Impact Factor: 2.384
View Export to BibTeX Export to EndNote
Herscher LL, Cook JA, Pacelli R, Pass HI, Russo A, Mitchell JB
Principles of chemoradiation: Theoretical and practical considerations (406 views)
Oncology (ISSN: 0890-9091), 1999 Oct; 13(10SUPPL.5): 11-22.
Impact Factor: 0.933
View Export to BibTeX Export to EndNote
Cook JA, Krishna MC, Pacelli R, DeGraff W, Liebmann J, Mitchell JB, Russo A, Wink DA
Nitric oxide enhancement of melphalan-induced cytotoxicity (486 views)
Br J Cancer (ISSN: 0007-0920, 0007-0920print, 0007-0920linking), 1997 Sep; 76(3): 325-334.
Impact Factor: 2.938
View Export to BibTeX Export to EndNote
Scala S, Pacelli R, Iaffaioli RV, Normanno N, Pepe S, Frasci G, Genua G, Tsuruo T, Tagliaferri P, Bianco AR
Reversal of adriamycin resistance by recombinant α-interferon in multidrug-resistant human colon carcinoma LoVo-doxorubicin cells (559 views)
Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 1991 Sep 15; 51(18): 4898-4902.
Impact Factor: 8.426
View Export to BibTeX Export to EndNote
47 Records (45 excluding Abstracts).
Total impact factor: 204.307 (197.343 excluding Abstracts).
Total 5 year impact factor: 212.224 (204.278 excluding Abstracts).
Total impact factor: 204.307 (197.343 excluding Abstracts).
Total 5 year impact factor: 212.224 (204.278 excluding Abstracts).
452 views. Last view on Thursday 19 January 2023, 22:00:38
ibb.cnr.it
