Does protracted antiviral therapy impact on HCV-related liver cirrhosis progression? (333 views)
World J Gastroentero (ISSN: 1007-9327, 2219-2840, 1007-9327linking), 2007 Sep 28; 13(36): 4903-4908.
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Paper type: Journal Article, Clinical Trial,
Impact factor: 2.433, 5-year impact factor: 2.633
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-34848871317&partnerID=40&md5=27b1bfc00263f0eabebea6908a5eb51e
Keywords: Antiviral Therapy, Hepatitis C Virus Infection, Liver Cirrhosis, Alpha Interferon, Antivirus Agent, Caffeine, Recombinant Erythropoietin, Recombinant Granulocyte Colony Stimulating Factor, Ribavirin, Adult, Alopecia, Anorexia, Artery Resistance, Article, Asthenia, Controlled Study, Cost Effectiveness Analysis, Disease Severity, Doppler Flowmetry, Dose Response, Erythema, Female, Fever, General Condition Improvement, Human, Liver Function, Liver Function Test, Liver Microsome, Major Clinical Study, Neutropenia, Outcome Assessment, Portal Hypertension, Psoriasis Vulgaris, Saliva Analysis, Scoring System, Urinary Tract Infection, Virus Replication, Antiviral Agents, Chronic, Interferon-Alpha, Middle Aged,
Affiliations:
*** IBB - CNR ***
Department of Clinical and Expermtal Medicine, Federico II University Medical School of Naples,Via S. Pansini, 5, Naples 80131, Italy. tarantin@unina.it
Department of Biomorphological and Functional Sciences, Pharmacology Section of Neuroscience Department, Federico II University Medical School of Naples, Naples 80131, Italy
References:
Not available.
World J Gastroentero (ISSN: 1007-9327, 2219-2840, 1007-9327linking), 2007 Sep 28; 13(36): 4903-4908.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Clinical Trial,
Impact factor: 2.433, 5-year impact factor: 2.633
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-34848871317&partnerID=40&md5=27b1bfc00263f0eabebea6908a5eb51e
Keywords: Antiviral Therapy, Hepatitis C Virus Infection, Liver Cirrhosis, Alpha Interferon, Antivirus Agent, Caffeine, Recombinant Erythropoietin, Recombinant Granulocyte Colony Stimulating Factor, Ribavirin, Adult, Alopecia, Anorexia, Artery Resistance, Article, Asthenia, Controlled Study, Cost Effectiveness Analysis, Disease Severity, Doppler Flowmetry, Dose Response, Erythema, Female, Fever, General Condition Improvement, Human, Liver Function, Liver Function Test, Liver Microsome, Major Clinical Study, Neutropenia, Outcome Assessment, Portal Hypertension, Psoriasis Vulgaris, Saliva Analysis, Scoring System, Urinary Tract Infection, Virus Replication, Antiviral Agents, Chronic, Interferon-Alpha, Middle Aged,
Affiliations:
*** IBB - CNR ***
Department of Clinical and Expermtal Medicine, Federico II University Medical School of Naples,Via S. Pansini, 5, Naples 80131, Italy. tarantin@unina.it
Department of Biomorphological and Functional Sciences, Pharmacology Section of Neuroscience Department, Federico II University Medical School of Naples, Naples 80131, Italy
References:
Not available.
Does protracted antiviral therapy impact on HCV-related liver cirrhosis progression?
AIM: To study the outcomes of patients with compensated hepatitis C virus-related cirrhosis.; METHODS: Twenty-four grade A5 and 11 grade A6 of Child-Pugh classification cirrhotic patients with active virus replication, treated for a mean period of 31.3 +/- 5.1 mo with moderate doses of interferon-alpha and ribavirin, were compared to a cohort of 36 patients with similar characteristics, without antiviral treatment. Salivary caffeine concentration, a liver test of microsomal function, was determined at the starting and thrice in course of therapy after a mean period of 11 +/- 1.6 mo, meanwhile the resistive index of splenic artery at ultra sound Doppler, an indirect index of portal hypertension, was only measured at the beginning and the end of study.; RESULTS: Eight out of the 24 A5- (33.3%) and 5 out of the 11 A6- (45.45%) treated-cirrhotic patients showed a significant improvement in the total overnight salivary caffeine assessment. A reduction up to 20% of the resistive index of splenic artery was obtained in 3 out of the 8 A5- (37.5%) and in 2 out of the 5 A6- (40%) cirrhotic patients with an improved liver function, which showed a clear tendency to decrease at the end of therapy. The hepatitis C virus clearance was achieved in 3 out of the 24 (12.5%) A5- and 1 out of the 11 (0.091%) A6-patients after a median period of 8.5 mo combined therapy. In the cohort of non-treated cirrhotic patients, not only the considered parameters remained unchanged, but 3 patients (8.3%) had a worsening of the Child-Pugh score (P = 0.001).; CONCLUSION: A prolonged antiviral therapy with moderate dosages of interferon-alpha and ribavirin shows a trend to stable liver function or to ameliorate the residual liver function, the entity of portal hypertension and the compensation status at acceptable costs.
AIM: To study the outcomes of patients with compensated hepatitis C virus-related cirrhosis.; METHODS: Twenty-four grade A5 and 11 grade A6 of Child-Pugh classification cirrhotic patients with active virus replication, treated for a mean period of 31.3 +/- 5.1 mo with moderate doses of interferon-alpha and ribavirin, were compared to a cohort of 36 patients with similar characteristics, without antiviral treatment. Salivary caffeine concentration, a liver test of microsomal function, was determined at the starting and thrice in course of therapy after a mean period of 11 +/- 1.6 mo, meanwhile the resistive index of splenic artery at ultra sound Doppler, an indirect index of portal hypertension, was only measured at the beginning and the end of study.; RESULTS: Eight out of the 24 A5- (33.3%) and 5 out of the 11 A6- (45.45%) treated-cirrhotic patients showed a significant improvement in the total overnight salivary caffeine assessment. A reduction up to 20% of the resistive index of splenic artery was obtained in 3 out of the 8 A5- (37.5%) and in 2 out of the 5 A6- (40%) cirrhotic patients with an improved liver function, which showed a clear tendency to decrease at the end of therapy. The hepatitis C virus clearance was achieved in 3 out of the 24 (12.5%) A5- and 1 out of the 11 (0.091%) A6-patients after a median period of 8.5 mo combined therapy. In the cohort of non-treated cirrhotic patients, not only the considered parameters remained unchanged, but 3 patients (8.3%) had a worsening of the Child-Pugh score (P = 0.001).; CONCLUSION: A prolonged antiviral therapy with moderate dosages of interferon-alpha and ribavirin shows a trend to stable liver function or to ameliorate the residual liver function, the entity of portal hypertension and the compensation status at acceptable costs.
Does protracted antiviral therapy impact on HCV-related liver cirrhosis progression?
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Does protracted antiviral therapy impact on HCV-related liver cirrhosis progression?
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22 Records (19 excluding Abstracts).
Total impact factor: 62.268 (50.43 excluding Abstracts).
Total 5 year impact factor: 59.228 (45.207 excluding Abstracts).
Total impact factor: 62.268 (50.43 excluding Abstracts).
Total 5 year impact factor: 59.228 (45.207 excluding Abstracts).
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